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SPARC-V - Vagus Nerve Mapping and Physiology
 

Reconstructing Vagal Anatomy (REVA) 75N98022-SPARC-RFP-28Jan2022
PI NameInstitution NameTitle
SHOFFSTAL, ANDREWCASE WESTERN RESERVE UNIVERSITYRECONSTRUCTING VAGAL ANATOMY
ZANOS, STAVROSFEINSTEIN INSTITUTE FOR MEDICAL RESEARCHRECONSTRUCTING VAGAL ANATOMY

 

SPARC VNS Endpoints from Standardized Parameters (VESPA) (U54 Clinical Trial Required) RFA-RM-22-002
PI NameInstitution NameTitle
OSBORN, JOHN W (contact)
EBERLY, LYNN E
IKRAMUDDIN, SAYEED
LIM, HUBERT HYUNGIL
MACEFIELD, VAUGHAN GARY
NAHAS, ZIAD
UNIVERSITY OF MINNESOTAREVEAL - Research Evaluating Vagal Excitation and Anatomical Linkages

 

SPARC-O - Open-source Neuromodulation Technologies

SPARC Human Open Research Neural Engineering Technologies (HORNET) Initiative (U41 Clinical Trial Not Allowed) RFA-RM-21-024
PI NameInstitution NameTitle
KILGORE, KEVIN L (contact) 
CHESTEK, CYNTHIA ANNE 
SMITH, BRIAN
CASE WESTERN RESERVE UNIVERSITYCleveland Open Source Modular Implant Innovators Community (COSMIIC)
MENG, ELLIS (contact)
HITTI, RAJA EDWARD
PIKOV, VICTOR
UNIVERSITY OF SOUTHERN CALIFORNIAHORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

 

SPARC-X - Challenge Competition

Neuromod Prize - Phase 2
WinnersTitle
DIMARCO, ANTHONY F.High-frequency spinal cord stimulation reduces respiratory tract infections and improves bowel management in people with neurological impairment
JUNIPER BIOMEDICAL (formerly RBI Medical)Ultraprecise, selective pelvic neuromodulation therapy treats stress urinary incontinence, overactive bladder, and fecal incontinence using a minimally invasive micro-implant
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.StimXS, neuromodulation of the lumbosacral spinal cord, automatically regulates cardiovascular, respiratory, and urinary systems after spinal cord injury
UNIVERSITY OF PITTSBURGH DEPARTMENT OF UROLOGYA multichannel implantable device for sacral-pudendal neuromodulation addresses bladder, bowel, and sexual disorders
Neuromod Prize - Phase 1
WinnersTitle
BIOS HEALTHThe Autonomic Therapy Initiative, data-driven stimulations of the vagus nerve using neural biomarkers, modulates cardiac function and minimizes side effects on off target organs
DIMARCO, ANTHONY F.High-frequency spinal cord stimulation reduces respiratory tract infections and improves bowel management in people with neurological impairment
GENERAL ELECTRIC RESEARCH, in collaboration with
NORTHWELL HEALTH
YALE UNIVERSITY
A single, image-guided ultrasound treatment induces a response in the gut-brain sensory pathway to provide sustained remission in Type 2 diabetes and obesity
GRILL, WARREN (and collaborators)
DUKE BIOMEDICAL ENGINEERING
Electrical recording and stimulation of the sacral nerve with closed-loop bioelectronic control restores bladder and bowel function
NEUROENGINEERING & PAIN RESEARCH (NPR) LAB UNIVERSITY OF CONNECTICUTSynchronized pulse and sinusoidal stimulation of sacral dorsal root ganglia (DRG) and nerve roots relieves chronic visceral pain in the lower abdominal organs by selectively blocking C-fiber neural transmission
RBI MEDICALUltraprecise, selective pelvic neuromodulation therapy treats stress urinary incontinence, overactive bladder, and fecal incontinence using a minimally invasive micro-implant
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.StimXS, neuromodulation of the lumbosacral spinal cord, automatically regulates cardiovascular, respiratory, and urinary systems after spinal cord injury
UNIVERSITY OF PITTSBURGH DEPARTMENT OF UROLOGYA multichannel implantable device for sacral-pudendal neuromodulation addresses bladder, bowel, and sexual disorders

SPARC 1 - Anatomical and Functional Mapping of the Innervation of Major Internal Organs

Targeted Needs to Achieve SPARC Program Goals (OT2) OTA-20-004
PI NameInstitution NameTitle
ARMITAGE, OLIVERBIOS HEALTH LTDEfficient mapping of neuromodulation therapy parameters to complex biomarker spaces
DANZIGER, ZACHARY CFLORIDA INTERNATIONAL UNIVERSITYA New Paradigm for Systems Physiology Modeling: Biomechanistic Learning Augmentation with Deep Differential Equation Representations (BLADDER)
GAUNT, ROBERT AUNIVERSITY OF PITTSBURGH AT PITTSBURGHSimulations of spinal cord recruitment to optimize bioelectronic interventions for lower urinary tract control
LIU, ZHONGMING (contact) 
CHENG, LEO 
UNIVERSITY OF MICHIGAN AT ANN ARBORThe Virtual Stomach
MAHMOUDI, BABAK (contact) 
KOTHARE, MAYURESH V 
EMORY UNIVERSITYCONTROL-CORE: A Modular Simulation Environment for Design and Prototyping of Closed-loop Peripheral Neuromodulation Control Systems using the O2S2PARC Platform
MARTONE, MARYANN E (contact)
DE BONO, BERNARD    
UNIVERSITY OF CALIFORNIA, SAN DIEGOK-CORE: Curation and Knowledge Management for SPARC
PATEL, BHAVESH CALIFORNIA MEDICAL INNOVATIONS INSTITUTESODA - Desktop Software to Enhance the SPARC Data Curation Workflow
VADIGEPALLI, RAJANIKANTHTHOMAS JEFFERSON UNIVERSITYModeling network dynamics of cardiac right atrial ganglionic plexus to enable in silico testing of vagal neurostimulation strategies
Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC): Comprehensive Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT2) RFA-RM-15-018
PI NameInstitution NameTitle
BOLSER, DONALD CUNIVERSITY OF FLORIDAFunctional mapping of peripheral and central circuits for airway protection and breathing
HOWARD, MARTHE JUNIVERSITY OF TOLEDO HEALTH SCI CAMPUSAnatomical-Functional Mapping of Enteric Neural Circuits
HUBSCHER, CHARLES H. (contact) 
HARKEMA, SUSAN J 
UNIVERSITY OF LOUISVILLEFunctional Mapping with Lumbosacral Epidural Stimulation for Restoration of Bladder Function After Spinal Cord Injury
POWLEY, TERRY L.PURDUE UNIVERSITYMapping Stomach Autonomic Circuitry and Function for Neuromodulation of Gastric Disorders
SHIVKUMAR, KALYANAM (contact) 
FOWLKES, CHARLESS 
GRADINARU, VIVIANA 
HABECKER, BETH A 
LIBERLES, STEPHEN DANIEL 
PATERSON, DAVID 
ZUCKER, IRVING H
UNIVERSITY OF CALIFORNIA LOS ANGELESComprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous System
TACHE, YVETTE FRANCEUNIVERSITY OF CALIFORNIA LOS ANGELESComprehensive Structural and Functional Mapping of Mammalian Colonic Nervous System

 

Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC): Foundational Functional Mapping of Neuroanatomy and Neurobiology of Organs (OT2) RFA-RM-15-020
PI NameInstitution NameTitle
CAMPBELL-THOMPSON, MARTHA LUNIVERSITY OF FLORIDANeuromodulation-based treatment of diabetes: identifying anatomical and physiological pancreatic innervation targets
KEAST, JANET RUNIVERSITY OF MELBOURNEUnderstanding functional connectivity of sensory and motor pathways to specific regions of the lower urinary tract.
LEWIS, STEPHEN JOHN CASE WESTERN RESERVE UNIVERSITYFunctional Mapping of the afferent and Efferent Projections of the Superior Cervical Ganglion Interactome
MUENZBERG-GRUENING, HEIKELSU PENNINGTON BIOMEDICAL RESEARCH CTRGenetically-based neuro-modulation of adipose tissue functions
NAPADOW, VITALY MASSACHUSETTS GENERAL HOSPITALMapping the linkage between auricular vagus nerve receptors and cardiovagal modulation
REARDON, COLIN (contact) 
RAYBOULD, HELEN E
UNIVERSITY OF CALIFORNIA AT DAVISMapping of the neuro-immune interface
SHEN, XILINGDUKE UNIVERSITYFunctional mapping of efferent gut neuroepithelial circuits
SOUTHARD-SMITH, E MICHELLEVANDERBILT UNIVERSITY MEDICAL CENTERENSMAP: Molecular and Functional Mapping of the Enteric Nervous System
SUN, XIN (contact) 
WANG, FAN
UNIVERSITY OF WISCONSIN-MADISONFoundational Mapping of the Neural Circuits that Control Intrinsic Lung Function
ZELTSER, LORI M COLUMBIA UNIVERSITY HEALTH SCIENCESFoundational tools to study the impacts of sympathetic activity on the neuroanatomy and function of brown adipose tissue

 

Stimulating Peripheral Activity to Relieve Conditions (SPARC):  Foundational Peripheral Neuroanatomy and Functional Neurobiology in Under-Studied Organs (U01) RFA-RM-17-003
PI NameInstitution NameTitle
FRENETTE, PAUL SALBERT EINSTEIN COLLEGE OF MEDICINE, INCEvaluating neural circuitry of the bone marrow
KOLLARIK, MARIANJOHNS HOPKINS UNIVERSITYIonic and Structural Mechanisms for Sensory Neuromodulation of the Esophagus
OSBORN, JOHN W (contact) 
THOMAS, MARK JOHN 
VULCHANOVA, LYUDMILA H
UNIVERSITY OF MINNESOTAStructural and functional neurobiology of renal nerves: A platform for neuromodulation of renal function
SCHELLER, ERICA LYNNWASHINGTON UNIVERSITYPERIPHERAL NERVE DISTRIBUTION AND FUNCTION WITHIN THE SKELETON

 


SPARC 2 - Next Generation Tools and Technologies

Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18) RFA-RM-15-002
PI NameInstitution NameTitle
ARDELL, JEFFREY L (contact) 
KIPKE, DARYL R 
SHIVKUMAR, KALYANAM 
UNIVERSITY OF CALIFORNIA LOS ANGELESDistributed electrode system for high-fidelity cardio-neural mapping
BRUNS, TIMOTHY M. (contact) 
YOON, EUISIK
UNIVERSITY OF MICHIGANDevelopment of a novel multi-modal spinal root interface
DAVIS, BRIAN M (contact) 
GLORIOSO, JOSEPH C.
UNIVERSITY OF PITTSBURGH AT PITTSBURGHNovel viral tools for control of bladder function and pain
DURAND, DOMINIQUE M (contact) 
LEWIS, STEPHEN JOHN
CASE WESTERN RESERVE UNIVERSITYNovel nanowire interface with the autonomic nervous system to study hypertension
FARAJIDAVAR, AYDIN (contact) 
KIANI, MEHDI  
MILLER, LARRY S
NEW YORK INST OF TECHNOLOGYAn Implantable Wireless System To Study Gastric Neurophysiology
GEREAU, ROBERT (contact) 
ROGERS, JOHN
WASHINGTON UNIVERSITYSoft, conformal wireless optoelectronic systems for the long-term neuromodulation of bladder function
HORN, CHARLES CHRISTOPHER (contact) 
JENKINS, MICHAEL W.
UNIVERSITY OF PITTSBURGH AT PITTSBURGHDefining gastric vagal mechanisms underlying emetic activation using novel electrophysiological and optical mapping technology
HOWARD, MARTHE JUNIVERSITY OF TOLEDO HEALTH SCI CAMPUSTool Building to Inform Structure-Functions relationships in the Autonomic Nervous System
OKUSA, MARK DOUGLAS (contact) 
HOSSACK, JOHN A
UNIVERSITY OF VIRGINIATailoring ultrasound technology to explore mechanisms of activation of the splenic neuroimmune axis in attenuating acute organ injury
STROHL, KINGMAN PERKINSCASE WESTERN RESERVE UNIVERSITYA Tool for Neurotheraputic Therapy for Sleep Disordered Breathing
VULCHANOVA, LYUDMILA HUNIVERSITY OF MINNESOTASelective peripheral neuromodulation through organ-specific AAV-mediated gene transfer
WELLS, JAMES M (contact) 
HELMRATH, MICHAEL A
CINCINNATI CHILDRENS HOSP MED CTREstablishment of in vitro and in vivo models of human gastrointestinal organoids with a functional ENS

 

Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC):  Technologies to Understand the Control of Organ Function by the Peripheral Nervous System (OT2) RFA-RM-16-003
PI NameInstitution NameTitle
DAMASER, MARGOT S. (contact) 
BOURBEAU, DENNIS
CLEVELAND CLINIC LERNER COM-CWRUConscious ambulatory bladder monitoring to understand neural control of lower urinary tract function
MCLAUGHLIN, BRYAN LMICRO-LEADS, INC.Epidural Current-Steering for Selective Modulation of Lower Urinary Tract Function
MONAGHAN, JAMES RNORTHEASTERN UNIVERSITYOptical Nanosensors Detect Neurotransmitter Release in the Peripheral Nervous System
SEYMOUR, JOHN P (contact) 
BRUNS, TIMOTHY M. 
YOON, EUISIK 
UNIVERSITY OF MICHIGANHighly-compliant Microneedle Arrays for Peripheral Nerve Mapping
STANLEY, SARAH AMYICAHN SCHOOL OF MEDICINE AT MOUNT SINAIRemote Modulation of the Peripheral Nervous System
WEIR, RICHARD FERGUS FFRENCHUNIVERSITY OF COLORADO DENVERDevelopment of a Bidirectional Optogenetic Minimally Invasive Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity

 

Limited Competition - Stimulating Peripheral Activity to Relieve Conditions (SPARC):  Technologies to Understand the Control of Organ Function by the Peripheral Nervous System (OT2) RFA-RM-17-010
PI NameInstitution NameTitle
AXELROD, STEVEG-TECH, INC.Adaptation and Extension of Wireless Wearable Patch System for Non-invasive Measurement of Myoelectric Signals from Gastrointestinal Organs
CLANCY, COLLEEN E (contact) 
GRANDI, ELEONORA 
SANTANA, LUIS F
UNIVERSITY OF CALIFORNIA AT DAVISDevelopment of the Predictive NeuroCardiovascular Simulator
GAUNT, ROBERT AUNIVERSITY OF PITTSBURGH AT PITTSBURGHSoft Silicone Electrode Nets: implantable technology for visceral organ neural interfacing and functional evaluation
GREGERSEN, HANS (contact) 
KASSAB, GHASSAN S
CALIFORNIA MEDICAL INNOVATIONS INSTITUTEFecobionics device for mapping colonic and anorectal neuromuscular function
GRILL, WARREN M DUKE UNIVERSITYModeling Activation and Block of Autonomic Nerves for Analysis and Design
HAVTON, LEIF AUNIVERSITY OF CALIFORNIA LOS ANGELESTransmission Electron Microscopy Service for SPARC Consortium Investigators
HOLDER, DAVID S UNIVERSITY COLLEGE LONDONEnhanced quantitative imaging of compound action potentials in multi-fascicular peripheral nerve with fast neural Electrical Impedance Tomography enabled by 3D multi-plane softening bioelectronics
JENKINS, MICHAEL WCASE WESTERN RESERVE UNIVERSITYInfrared Neuromodulation Reveals a New Understanding of Ganglion Organization
MILLER, LARRY SFEINSTEIN INSTITUTE FOR MEDICAL RESEARCHUsing the GI Tract as a Window to the Autonomic Nervous System in the Thorax and in the Abdomen
REZNIKOV, LEAH RUNIVERSITY OF FLORIDATransgenic Pigs with Red-Shifted Channelrhodopsin-Citrine Fusion Proteins
SOH, HYONGSOK TOMSTANFORD UNIVERSITYReal-time biosensor for mapping the function of the pancreas
VAKOC, BENJAMIN JAMESMASSACHUSETTS GENERAL HOSPITALNovel optical coherence tomography tool development for quantitative peripheral nerve imaging

SPARC 3 - Translational Partnerships for Human Functional Mapping and New Indications

 

SPARC Partnership Opportunity: Custom Arrangements for Device-Based Clinical Studies with Flexible Data and Intellectual Property Rights (OT2) OTA-18-019
PI NameInstitution NameTitle
BRUNS, TIMOTHY MUNIVERSITY OF MICHIGAN AT ANN ARBORPudendal nerve mapping towards improved neuromodulation for urinary retention
CHEN, PENG-SHENGINDIANA UNIV-PURDUE UNIV AT INDIANAPOLISUsing electrical nerve stimulation to control atrial fibrillation
GREGERSEN, HANSCALIFORNIA MEDICAL INNOVATIONS INSTITUTENeurophysiological mechanism in sacral neuromodulation in patients suffering from fecal incontinence
SHIVKUMAR, KALYANAM (contact)
GREEN, ALEXANDER LAURENCE
UNIVERSITY OF CALIFORNIA LOS ANGELESCARDIAC NEUROMODULATION IN HUMANS: MECHANISMS & THERAPIES
WARD, MATTHEW PETERPURDUE UNIVERSITYHigh Resolution, Noninvasive Measurement and Functional Classification of Vagal Nerve Response Patterns in Relation to Gastroparesis Symptom Management using Gastric Electrical Stimulation

 

Pre-clinical Development of Existing Market-approved Devices to Support New Market Indications (U18) RFA-RM-16-009
PI NameInstitution NameTitle
CANNING, BRENDAN J (contact) 
KOLLARIK, MARIAN 
MITZNER, WAYNE 
JOHNS HOPKINS UNIVERSITYNeuromodulation for Asthma
CHEN, JIANDEJOHNS HOPKINS UNIVERSITYSmart spinal cord stimulation for gastroparesis
YIN, JIEYUN NONETRANSTIMULATION RESEARCH, INC.Vagal Nerve Stimulation for Diabetes

 

Stimulating Peripheral Activity to Relieve Conditions (SPARC): Pre-clinical Development of Existing Market-approved Devices to Support New Market Indications (U18) RFA-RM-16-027
PI NameInstitution NameTitle
CHEN, PENG-SHENGINDIANA UNIV-PURDUE UNIV AT INDIANAPOLISSubcutaneous nerve stimulation for arrhythmia control.
HORN, CHARLES CHRISTOPHERUNIVERSITY OF PITTSBURGH AT PITTSBURGHClosed-loop neuroelectric control of emesis and gastric motility

SPARC 4 - Data and Resource Center

Targeted Needs to Achieve SPARC Program Goals (OT2) OTA-20-004
PI NameInstitution NameTitle
MARTONE, MARYANN E (contact)
DE BONO, BERNARD
UNIVERSITY OF CALIFORNIA, SAN DIEGOK-CORE: Curation and Knowledge Management for SPARC
Stimulating Peripheral Activity to Relieve Conditions (SPARC): Data Coordination, Mapping, and Modeling Center (OT3) RFA-RM-16-008
PI NameInstitution NameTitle
HUNTER, PETER JOHNUNIVERSITY OF AUCKLANDMulti-scale, multi-organ, multi-species SPARC map management
KUSTER, NIELSIT'IS FOUNDATIONOpen Platform for Online Simulations for Stimulating Peripheral Activity to Relieve Conditions – o2S2PARC
WAGENAAR, JOOST BBLACKFYNN, INC.Blackfynn: A scalable and sustainable platform for scientific data integration and analysis

SPARC 5 - Visceral Pain Circuitry

Stimulating Peripheral Activity to Relieve Conditions (SPARC): Anatomical and Functional Mapping of Pain-Related Visceral Organ Neural Circuitry (U01 Clinical Optional)
RFA-RM-19-001
PI NameInstitution NameTitle
CHENG, ZIXI JACKUNIVERSITY OF CENTRAL FLORIDANociceptive Afferent Topographical Innervation of the Heart and Stomach
FENG, BINUNIVERSITY OF CONNECTICUT STORRSDetermining the topology and molecular profiles of nociceptive DRG neurons innervating distal colon and rectum
JULIUS, DAVID (contact)
INGRAHAM, HOLLY A.
UNIVERSITY OF CALIFORNIA, SAN FRANCISCOMapping gut-spinal cord connections in visceral pain
MULUGETA, MILLIONUNIVERSITY OF CALIFORNIA LOS ANGELESStructural and functional mapping of visceral pain afferent neurocircuitries of the colorectum and bladder in preclinical models
TAYLOR-CLARK, THOMAS EDWARD (contact)
KOLLARIK, MARIAN
UNIVERSITY OF SOUTH FLORIDAComparative mapping of functionally distinct visceral afferent nociceptive pathways

 


Related Opportunities

NIH Support for Conferences and Scientific Meetings (Parent R13) PA-16-294
PI NameInstitution NameTitle
ROLANDI, MARCOUNIVERSITY OF CALIFORNIA SANTA CRUZAsilomar Bioelectronics Symposium 2017

 

This page last reviewed on February 27, 2024