High-Risk, High-Reward Research Program

Funding opportunities for outstanding scientists at all career stages

The High-Risk, High-Reward Research program supports exceptionally creative scientists pursuing highly innovative research with the potential for broad impact in biomedical, behavioral, or social sciences within the NIH mission. The program's four constituent NIH Director's awards provide a diverse set of funding opportunities.

NIH Director's Pioneer Award NIH Director's New Innovator Award NIH Director's Transformative Research Award NIH Director's Early Independence Award

Funding Opportunities

FY Pioneer Award New Innovator
Research Award
Early Independence
2020 RFA-RM-19-005
Closed September 6, 2019
Closed August 26, 2019
Closed September 20, 2019
Closed September 13, 2019

What Is the High-Risk, High-Reward Research Program? (1 minute video)

An audio-described version of this video is also available.

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This page last reviewed on October 1, 2019