High-Risk, High-Reward Research Program
Funding opportunities for outstanding scientists at all career stages
The High-Risk, High-Reward Research program supports exceptionally creative scientists pursuing highly innovative research with the potential for broad impact in biomedical or behavioral science. The program's four constituent NIH Director's awards provide a diverse set of funding opportunities.
The Common Fund’s High-Risk, High-Reward Research program was created to accelerate the pace of biomedical discoveries by supporting exceptionally creative scientists with highly innovative research. The program seeks to identify scientists with high-impact ideas that may be risky or at a stage too early to fare well in the traditional peer review process. The program encourages creative, outside-the-box thinkers to pursue exciting and innovative ideas in any area of biomedical or behavioral research relevant to the NIH mission. Four initiatives were created for this purpose:
The NIH Director’s Pioneer Award, established in 2004, challenges investigators at all career levels to pursue new research directions and develop groundbreaking, high-impact approaches to a broad area of biomedical or behavioral science.
The NIH Director’s New Innovator Award, established in 2007, supports unusually innovative research from early career investigators who are within 10 years of their final degree or post-graduate clinical training and have not yet received a research project grant or equivalent NIH grant.
The NIH Director’s Transformative Research Award, established in 2009, promotes cross-cutting, interdisciplinary approaches and is open to individuals and teams of investigators who propose unconventional research that could create or challenge existing paradigms.
The NIH Director’s Early Independence Award, established in 2010, provides an opportunity for exceptional junior scientists who have recently received their doctoral degree or completed their post-graduate clinical training to skip traditional post-doctoral training and move immediately into independent research positions.
Learn more about the different requirements for the awards from our interactive table.
|FY||Pioneer Award||New Innovator
Closes September 6, 2019
Closes August 26, 2019
Closes September 20, 2019
Closes September 13, 2019
What Is the High-Risk, High-Reward Research Program? (1 minute video)
An audio-described version of this video is also available.
This page last reviewed on May 15, 2019