The Human BioMolecular Atlas Program
In organisms consisting of multiple cell types, diverse cells with different functions and structures develop as we grow and age. The organization and variability of these cells have a profound impact on the function of different tissues, process of aging, and emergence of diseases and conditions. Recently developed technologies are allowing researchers to explore cells on the individual (single cell) level and provide an opportunity to establish a census of cells in human tissues and to study functional interactions among single cells. The Human BioMolecular Atlas Program (HuBMAP) aims to facilitate research on single cells within tissues by supporting data generation and technology development to explore the relationship between cellular organization and function, as well as variability in normal tissue organization at the level of individual cells.
HuBMAP will scale-up the scope of tissues, technologies, data management and community engagement over the course of the program. The program will have four stages: a setup phase in Fiscal Year (FY) 2018, a scale-up phase FY19-21, a production phase FY22-24 and a transition phase in FY25. All activities are pending the availability of funds. The four research initiatives that compose the program are:
- Technology Development:
- Transformative Technology Development - This set of initiatives, the first of which will be issued FY18 will accelerate the development of in situ imaging and sequencing approaches, single cell proteomics, methylomics and metabolomics as well as analysis of the extracellular environment that have the potential to transform 3D human tissue mapping.
- Rapid Technology Development - This set of initiatives, which is planned to start in FY19, will focus on nimble development and integration of existing imaging and dissociative technologies that will enhance data collection and validation during the program, and expanding throughput, multiplexing or discrimination of different classes of biomolecules.
- Tissue Mapping Centers - These Centers, which will be initially funded through a funding opportunity announcement in FY18, will build, benchmark, standardize, validate and generate extensive data from high-content, high-throughput imaging and omics technologies to produce comprehensive 3D tissues maps with cellular spatial resolution. These centers will integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through to map reconstruction integrating both imaging and omics data and analysis.
- Data Hub and Coordination Center - This multi-component center, that will be funded in FY18, will have responsibility for: 1) managing the data generated by the Consortium, 2) coordinating internal and external Consortium activities, 3) developing novel tools for visualizing, searching and modeling data and 4) building an atlas of tissue maps.
- Demonstration Projects - The goal of this initiative, which will start half way through the program, is to demonstrate how HuBMAP resources, in combination with new or other datasets or biospecimens as needed, can be used to build better statistical and analytic tools and models of cellular organization and communication in tissues.
This page last reviewed on September 5, 2017