Program Snapshot

Knowing the structure of a molecule reveals important information about how it functions and can provide insight into potential drug targets for fighting disease. Cryo-electron microscopy (cryo-EM) is a method used to image frozen biological molecules without the use of structure-altering dyes or fixatives, providing a more accurate picture of the molecules and greater understanding of biological function. However, the high cost of cryo-EM limits the method’s availability to researchers. The NIH Common Fund's Transformative High Resolution Cryo-Electron Microscopy program aims to provide nationwide access for researchers to cryo-EM through the creation of national service centers, improvement of the technology, and the development of an expert workforce.

This page last reviewed on November 14, 2017