Cloud Credits Program

The Gabriella Miller Kids First Pediatric Research Program (Kids First) Cloud Credits Program was developed and implemented to enable researchers to conduct cloud-based analyses accessing Kids First data and utilizing the tools available through the Kids First Data Resource (DRC). This program is available to all researchers interested in using Kids First Data Resources. The program is powered by Kids First-supported investigators who collect and submit genomic data. The Kids First DRC receives source clinical data from each independent investigator, along with paired genomic sequencing produced by one of their sequencing centers partners and provides harmonized clinical and genomic datasets through its web platforms. The Kids First DRC processes each study dataset according to the same standard workflows, producing harmonized datasets which are directly comparable to one another, and facilitating cross-disease analyses.

The Kids First Data Resource Portal and the analysis tools within it allow users to query or search Kids First datasets, build virtual cohorts or collections of individual participants, identify genomic files for analysis, and search for variants common across Kids First studies. CAVATICA, built by Seven Bridges Genomics, allows users to analyze and visualize data using bioinformatics workflows and interactive analysis in a cloud-based environment.

If you would like to participate in the Kids First Cloud Credits Pilot program. Please fill out the form on the Kids First Data Resource Center Cloud Credits Page. A member of the Kids First Working Group will follow up with you with instructions and logistics.

Cloud Credits are expected to be used within six months, and can be extended. If you are requesting a continuation those granted credits, please send an email to [email protected] with “Kids First Cloud Credits Pilot Continuation” in the subject line, and the Working Group will follow up with you.

If you would like additional information on cloud computing, with specific reference to Kids First, please see https://github.com/kids-first/kf-cloud-credits.

Please note that dbGaP approval is required for access to controlled-access (generally, individual-level genomic) data. Requesting dbGaP access requires a separate proposal and submission.

For a tutorial about dbGaP access, including Tips for developing a Data Access Request, please see https://github.com/kids-first/kf-cloud-credits/blob/main/ExploringDatasets.md.

A FAQ is available about data access: https://commonfund.nih.gov/kidsfirst/FAQ.