Funded Research

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2024 NIH Director’s Transformative Research Award (R01) (RFA-RM-23-006)

PI Name	Institution Name	Title
BERRO, JULIEN (contact) GREEN, ALEXANDER ARTHUR SU, XIAOLEI	YALE UNIVERSITY	Programming cellular behavior by mechanical forces
DRANOVSKY, ALEX	NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	Astrocytes as the integrators of neuromodulator signals
FLYNN, RYAN ALEXANDER	BOSTON CHILDREN'S HOSPITAL	Functional characterization of cell surface RNA biology
HANSEN, ANDERS SEJR	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Resolving transcription factor target search mechanisms
KALANTRY, SUNDEEP	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Evolution of Mammalian Sex Chromosome Dosage Compensation
LONGMAN, RANDY S (contact) GUO, CHUN-JUN WRIGHT, AARON TODD	WEILL MEDICAL COLL OF CORNELL UNIV	Activity Probes to Guide Precision Microbiome Therapy
LU, RONG (contact) ELOWITZ, MICHAEL B	UNIVERSITY OF SOUTHERN CALIFORNIA	A spatial view of hematopoietic regeneration dynamics in the bone marrow

2023 NIH Director’s Transformative Research Award (R01) (RFA-RM-22-020)

*Diversity Statement

PI Name	Institution Name	Title
CARVUNIS, ANNE-RUXANDRA (contact) ATIANAND, MANINJAY K JOGLEKAR, ALOK SUBRAMANIAM, ARVIND	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Unraveling microprotein biology with an evolutionary-immunological framework
KODADEK, THOMAS J	UNIVERSITY OF FLORIDA	Development of Ubiquitin-Independent Degraders
RINBERG, DMITRY	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Odorprint Based Disease Diagnostics
ROUKES, MICHAEL L	CALIFORNIA INSTITUTE OF TECHNOLOGY	Next-generation spatial -omics: High-throughput, single-molecule proteomic imaging with subcellular resolution
SHIN, LISA MARIE (contact) ALLEN, AERIELLE SOMMERS, SAMUEL	TUFTS UNIVERSITY MEDFORD	Effects of Racism on Brain and Physiological Pathways to Health Disparities
TYNES, BRENDESHA MARIE	UNIVERSITY OF SOUTHERN CALIFORNIA	Using Immersive Virtual Reality and Media Literacy to Enhance Adolescents' Coping Skills in the Face of Traumatic Online Experiences

2022 NIH Director's Transformative Research Award (R01) (RFA-RM-21-017)

*Diversity Statement

PI Name	Institution Name	Title
ANDERSEN, JULIE KAY	BUCK INSTITUTE FOR RESEARCH ON AGING	A Smart Cell Drug (SmaCD) Delivery Platform for Mobile, Targetable, and Self-Regulated Combination Therapy: A Model Project to Rescue Antibodies from Alzheimers Disease (AD) Clinical Trial Failures
ANTON, EVA S (contact) LICHTMAN, JEFF W YASUDA, RYOHEI	UNIV OF NORTH CAROLINA CHAPEL HILL	Primary Cilia: A Novel Signaling Gateway to Neural Circuit Modulation
BEAUCHAINE, THEODORE PATRICK (contact) SHEFTALL, ARIELLE HOPE VALENTINO, KRISTIN	UNIVERSITY OF NOTRE DAME	Leveraging Noninvasive Transcutaneous Vagus Nerve Stimulation and Smartphone Technology to Reduce Suicidal Behaviors and Suicide Among Highly Vulnerable Adolescents
BISHEHSARI, FARAZ	RUSH UNIVERSITY MEDICAL CENTER	Development of a Precision Medicine Platform for Circadian Based Therapeutics in Pancreatic Cancer
BRADY, DONITA C (contact) BURSLEM, GEORGE BUSINO, LUCA GADE, TERENCE P WITZE, ERIC S	UNIVERSITY OF PENNSYLVANIA	Unlocking the Chemical Space of Cancer-Associated Perturbations
FISCHBACH, MICHAEL ANDREW	STANFORD UNIVERSITY	Building the Foundations of Commensal Vaccines
ICHIDA, JUSTIN KAWIKA (contact) GOODARZI, HANI	UNIVERSITY OF SOUTHERN CALIFORNIA	Leveraging Natural Phenotypic Variations of Heterogenous ALS Populations-in-a-Dish to Enable Scalable Drug Discovery
VAN RYZIN, MARK J	UNIVERSITY OF OREGON	Transforming Adolescent Mental Health Through Accessible, Scalable, Technology-Supported Small-Group Instruction
ZINN, KAI G (contact) GARCIA, KENAN CHRISTOPHER THOMSON, MATTHEW	CALIFORNIA INSTITUTE OF TECHNOLOGY	A Global Map of Interactions Among Human Cell Surface Proteins and Secreted Ligands

2021 NIH Director's Transformative Research Award (R01) (RFA-RM-20-013)

*Diversity Statement

PI Name	Institution Name	Title
BELLAMKONDA, RAVI V	DUKE UNIVERSITY	Tumor Tractor Beam for Diffuse Cancers
BLACK, BEN E (contact) LAMPSON, MICHAEL	UNIVERSITY OF PENNSYLVANIA	Mendelian Inheritance of Artificial Chromosomes
GITAI, ZEMER (contact) ABOU DONIA, MOHAMED MURPHY, COLEEN TARA	PRINCETON UNIVERSITY	Small RNAs as Novel Modulators of Microbe-Host Interactions
KIMBRO, KEVIN SEAN (contact) NAVARRO, HERNAN A WILLIAMS, KEVIN PETER	NORTH CAROLINA CENTRAL UNIVERSITY	Addressing the Biology of Health Disparities by Targeting Geographical Ancestry-Driven Variants of Immunity
NAAR, SYLVIE (contact) ANDERSON, NORMAN B PETTUS-DAVIS, CARRIE	FLORIDA STATE UNIVERSITY	Transforming Health Equity Research in Integrated Primary Care: Antiracism as a Disruptive Innovation
OKWAN-DUODU, DERICK	CEDARS-SINAI MEDICAL CENTER	High Dimensional Atlas of Circulating Neutrophils as Reporters of Solid Organ Functional Status
POSPISILIK, JOHN ANDREW (contact) NADEAU, JOSEPH H	VAN ANDEL RESEARCH INSTITUTE	Master Regulators of Unexplained Variation in Disease Risk
ROBERTS, TODD F (contact) HAMRA, F KENT TAKAHASHI, JOSEPH S	UT SOUTHWESTERN MEDICAL CENTER	The Genetic Basis of Vocal Learning
WESEMANN, DUANE R	BRIGHAM AND WOMEN'S HOSPITAL	Flipped Germinal Centers
YUN, SEOK-HYUN ANDY	MASSACHUSETTS GENERAL HOSPITAL	Laser Particles for Multi-Dimensional Single-Cell Analysis

2021 NIH Director's Transformative Research Award (R01) Amyotrophic Lateral Sclerosis (ALS) Awards - NOT-RM-20-019

The Accelerating Leading-edge Science in ALS (ALS²) initiative issued an opportunity to support ALS research through several Transformative Research Awards. The initiative aims to dramatically advance the understanding of what triggers and drives the rapid progression of ALS.

PI Name	Institution Name	Title
DONNELLY, CHRISTOPHER JAMES (contact) BELZIL, VERONIQUE HEIMAN, MYRIAM KELLIS, MANOLIS	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Identification of TDP-43 Modifiers Through Single-Cell Transcriptional and Epigenomic Dissection of ALS and FTLD-MND
FELDMAN, EVA LUCILLE (contact) BATTERMAN, STUART A GOUTMAN, STEPHEN SARTOR, MAUREEN AGNES	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Developing Novel Strategies for Personalized Treatment and Prevention of ALS: Leveraging the Global Exposome, Genome, Epigenome, Metabolome, and Inflammasome with Data Science in a Case/Control Cohort
LU, QUN	EAST CAROLINA UNIVERSITY	Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression Diseases
PHATNANI, HEMALI (contact) HOLT, LIAM JOSEPH YAMAMOTO, AI	COLUMBIA UNIVERSITY HEALTH SCIENCES	The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

2021 NIH Director's Transformative Research Award (R01) Emergency COVID-19 Awards - RFA-RM-20-020

Due to the public health emergency, the Transformative Research Award and Early Independence Award issued additional funding opportunities for COVID-19-related research on the prevention of, preparation for, or response to coronavirus SARS-CoV-2 using funds provided through the CARES Act.

PI Name	Institution Name	Title
DEB, ARJUN (contact) ARUMUGASWAMI, VAITHILINGARAJA GRAEBER, THOMAS G PELLEGRINI, MATTEO	UNIVERSITY OF CALIFORNIA LOS ANGELES	Metabolic and Epigenetic Reprogramming of Vital Organs in SARS-CoV-2 Induced Systemic Toxicity
MANCEBO, RICARDO	GENENDEAVOR, LLC	Development of a Handheld Rapid Air Sensing System to Monitor and Quantify SARS-CoV-2 in Aerosols in Real-Time
RAY, ANIMESH (contact) HERNANDEZ, JENIFFER BERTHA	KECK GRADUATE INST OF APPLIED LIFE SCIS	Rapid Response for Pandemics: Single Cell Sequencing and Deep Learning to Predict Antibody Sequences Against an Emerging Antigen
WEINBERGER, LEOR S (contact) RODICK, ROBERT	VXBIOSCIENCES, INC.	Autonomously Deploying, Co-Evolving SARS-CoV-2 Antiviral: A New Paradigm for Pandemic Prevention
YAKOUB, ABRAAM M (contact) LAZARTIGUES, ERIC D TSENG, CHIEN-TE K	UNIVERSITY OF NORTH DAKOTA	SARS-CoV-2 Tropism in the Brain and Its Relationship to COVID-19 Pathogenesis

2020 NIH Director's Transformative Research Award (R01) (RFA-RM-19-007)

*Diversity Statement

PI Name	Institution Name	Title
ADAMS, PETER D	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	Defining Chromostasis - A Candidate Regulator of Healthy Aging and Longevity
BASS, BRENDA L (contact) ELDE, NELS C JACKMAN, JANE ELIZABETH STETSON, DANIEL B	UNIVERSITY OF UTAH	Unlocking Evolutionarily Latent Immune Functions for Treating Disease
BROWN, BRIAN D	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	Development of a Platform for Spatial Functional Genomics
CHUN, JEROLD	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	Transformative Research on Somatic Gene Recombination in the Normal and Alzheimers Disease-Related Dementia Brain
DITTEL, BONNIE N	VERSITI WISCONSIN, INC.	Development of a B Cell Therapeutic
GUTTMAN, MITCHELL	CALIFORNIA INSTITUTE OF TECHNOLOGY	How Phase-Separation in the Nucleus Organizes 3D Spatial Assembly and Gene Regulation
HEDSTROM, LIZBETH K	BRANDEIS UNIVERSITY	Ubiquitin-Independent Targeted Protein Degradation
HESSELBERTH, JAY R	UNIVERSITY OF COLORADO DENVER	Biochemistry at Single-Cell Resolution: A New Approach to Understand Functional Heterogeneity
LIU, CHANG C (contact) KRUSE, ANDREW MARKS, DEBORA S	UNIVERSITY OF CALIFORNIA-IRVINE	Making Antibody Generation Rapid, Scalable, and Democratic Through Machine Learning and Continuous Evolution

2019 NIH Director's Transformative Research Award (R01) (RFA-RM-18-009)

*Advisory Committee to the NIH Director Working Group Findings

PI Name	Institution Name	Title
BREM, RACHEL BETH (contact) BAUTISTA, DIANA MICHELE ELLERBY, LISA M VERDIN, ERIC M	BUCK INSTITUTE FOR RESEARCH ON AGING	Genetic Dissection of Trait Variation Between Long-Diverged Mouse Species
CHAIT, BRIAN T	ROCKEFELLER UNIVERSITY	Development of Next Generation Mass Spectrometric Instrumentation for Proteomics
DEDON, PETER C (contact) ALM, ERIC JOHN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Epigenetics of the Human Gut Microbiome
DENNY, CHRISTINE ANN (contact) RAMIREZ, STEVE	NEW YORK STATE PSYCHIATRIC INSTITUTE	Single-Cell and Target-Specific Resolution of Multiple Memories Across the Brain
GEISSMANN, FREDERIC	SLOAN-KETTERING INST CAN RESEARCH	Role of Microglia Somatic Variants in Neurodegenerative Diseases
GLADYSHEV, VADIM N	BRIGHAM AND WOMEN'S HOSPITAL	Unbiased Identification of Interventions that Extend Lifespan
JARVIS, ERICH D	ROCKEFELLER UNIVERSITY	Neuroengineering a Robust Vocal Learning Phenotype in Mice as a Model for Treating Communication Disorders
RAJ, ARJUN (contact) JAIN, RAJAN	UNIVERSITY OF PENNSYLVANIA	Decoding the Bridges and Barriers to Cellular Reprogramming and Lineage Identity
SHEPHERD, JASON D (contact) CAMPBELL, EDWARD M GALLAGHER, THOMAS MILLER	UNIVERSITY OF UTAH	Virus-Like Intercellular Communication in the Nervous System

2018 NIH Director's Transformative Research Award (R01) (RFA-RM-17-007)

*Commitment to Diversity

PI Name	Institution Name	Title
ALBEANU, DINU FLORENTIN (contact) KOULAKOV, ALEXEI	COLD SPRING HARBOR LABORATORY	A High-Throughput Sequencing and Imaging Approach to Understand the Functional Basis of Olfaction
DEISSEROTH, KARL A (contact) BRUNET, ANNE	STANFORD UNIVERSITY	Brain-Wide Screen for a Neural Pacemaker of Aging
KODADEK, THOMAS J	SCRIPPS FLORIDA	Phenotypic Screening Using DNA-Encoded Libraries
KORNBERG, ROGER D	STANFORD UNIVERSITY	Three-Dimensional Structure of Eukaryote Chromosomes
LEE, RICHARD T	HARVARD UNIVERSITY	Novel Age-Dependent DNA Modifications
PAYNE, AIMEE S (contact) MASON, NICOLA J	UNIVERSITY OF PENNSYLVANIA	Translating Cellular Immunotherapies for Autoimmunity to Canine Clinical Trials
PERRIMON, NORBERT (contact) CARR, STEVEN A MCMAHON, ANDREW P TING, ALICE Y	HARVARD MEDICAL SCHOOL	Mapping Protein Communication Between Organs in Homeostasis and Disease
SCHIFF, STEVEN J	PENNSYLVANIA STATE UNIV HERSHEY MED CTR	Predictive Personalized Public Health (P3H): A Novel Paradigm to Treat Infectious Disease
STRICK, PETER	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	The Neural Basis of the Brain-Body Connection
TRAVER, DAVID (contact) BAO, ZHIRONG HUISKEN, JAN	UNIVERSITY OF CALIFORNIA, SAN DIEGO	An Integrative Cellular Blueprint of Vertebrate Tissue Development

2017 NIH Director's Transformative Research Award (R01) (RFA-RM-16-007)

*Statement on Diversity

PI Name	Institution Name	Title
ANDREWS, ANNE MILASINCIC	UNIVERSITY OF CALIFORNIA LOS ANGELES	Micro- to Nanoscale Neurochemical Sensors
BENNER, STEVEN A	FOUNDATION FOR APPLIED MOLECULAR EVOLUTN	Transforming Life Sciences: Artificial Life
BOYDEN, EDWARD S	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-Performance Imaging through Scattering Living Tissue
CHIU, DANIEL T (contact) VAUGHAN, JOSHUA	UNIVERSITY OF WASHINGTON	Spatially Resolved Transcriptomics Enabled by Ultrabright Pdot Probes for Interrogation of Complex Tissues
DAVIDSON, KARINA W	COLUMBIA UNIVERSITY HEALTH SCIENCES	Re-engineering Precision Therapeutics through N-of-1 Trials
ELOWITZ, MICHAEL B (contact) CAI, LONG LOIS, CARLOS	CALIFORNIA INSTITUTE OF TECHNOLOGY	MEMOIR: Recording, and In Situ Readout of Cell Lineage and Transcriptional History
JOHNSTON, CHRISTOPHER D	FORSYTH INSTITUTE	The SyngenicDNA and μPOET Platform: Overcoming Innate Barriers to Genetic Engineering in Bacteria
MUCIDA, DANIEL S	ROCKEFELLER UNIVERSITY	Functional Mapping of Enteric-Associated Neurons

2016 NIH Director's Transformative Research Award (R01) (RFA-RM-15-005)

PI Name	Institution Name	Title
CHOUDHARY, AMIT (contact) SECOR, STEPHEN M WAGNER, BRIDGET K	BROAD INSTITUTE, INC.	Leveraging Snakes Extreme Physiology to Modulate Human Beta-Cell Function
HEDRICK, STEPHEN M (contact) BIER, ETHAN GOLDRATH, ANANDA W	UNIVERSITY OF CALIFORNIA SAN DIEGO	Mutagenic Chain Reaction-Facilitated Immunotherapy
LESSER, CAMMIE (contact) GARRETT, WENDY S LEONG, JOHN M	MASSACHUSETTS GENERAL HOSPITAL	Designer Probiotics for the Treatment of Intestinal Infection and Inflammation
LESTER, HENRY A	CALIFORNIA INSTITUTE OF TECHNOLOGY	Fluorescent Biosensors for Subcellular Pharmacokinetics
MAGGERT, KEITH A	UNIVERSITY OF ARIZONA	Induced Transgenerational Inheritance without Epigenetics
RANGANATHAN, RAMA	UT SOUTHWESTERN MEDICAL CENTER	Seeing Protein Mechanics: The Link between Molecular Structure, Function, and Evolution
RIENSTRA, CHAD M (contact) MORRISSEY, JAMES H TAJKHORSHID, EMAD	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Toolkit for High-Resolution Structure and Dynamics of Functional Lipids
WOOLLEY, CATHERINE S	NORTHWESTERN UNIVERSITY	New Tools to Study Neurosteroid Estrogens
WU, CHAO-TING	HARVARD MEDICAL SCHOOL	Culling the Human Genome of Disease Variants Using Ultraconserved Elements
YANKNER, BRUCE A (contact) CHURCH, GEORGE M	HARVARD MEDICAL SCHOOL	Exploring a Novel Paradigm of Schizophrenia and Bipolar Disorder
ZHANG, XIAOJING	DARTMOUTH COLLEGE	Implantable Cardiac Power Generation Using Flexible 3D Porous Thin Films
ZHUANG, XIAOWEI (contact) DULAC, CA THERINE G	HARVARD UNIVERSITY	In Situ Transcriptome Imaging in Single Cells

2015 NIH Director's Transformative Research Award (R01) (RFA-RM-14-003)

PI Name	Institution Name	Title
ALLBRITTON, NANCY L (contact) BULTMAN, SCOTT J GOMEZ, SHAWN MICHAEL MAGNESS, SCOTT T	UNIV OF NORTH CAROLINA CHAPEL HILL	Development of Human Intestinal Simulacra
BADAWI, RAMSEY D (contact) CHERRY, SIMON R	UNIVERSITY OF CALIFORNIA AT DAVIS	EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PET
BARKER, THOMAS HARRISON	GEORGIA INSTITUTE OF TECHNOLOGY	Mechanosensors that Detect and Treat Lung Fibrosis
DOLINOY, DANA	UNIVERSITY OF MICHIGAN	Development of piRNAs for Target-Specific Methylation
HETZER, MARTIN W	SALK INSTITUTE FOR BIOLOGICAL STUDIES	The Role of Long-Lived Proteins in the Survival of Nerve Cells
HOTOPP, JULIE	UNIVERSITY OF MARYLAND BALTIMORE	Extent and Significance of Bacterial DNA Integrations in the Human Cancer Genome
TAVAZOIE, SAEED F	COLUMBIA UNIVERSITY HEALTH SCIENCES	Massively Parallel Mapping of All Molecular Interactions in a Single Tube
ZHANG, FENG	BROAD INSTITUTE, INC.	Massively-Parallel Functional Interrogation of Psychiatric Genetics

2014 NIH Director's Transformative Research Award (R01) (RFA-RM-13-008)

PI Name	Institution Name	Title
ARNOLD, DONALD B (contact) FRASER, SCOTT E KESSELMAN, CARL	UNIVERSITY OF SOUTHERN CALIFORNIA	Dynamic Mapping of the Complete Synaptome Using Recombinant Probes
GIMELBRANT, ALEXANDER	DANA-FARBER CANCER INSTITUTE	Mechanism and Function of Autosomal Analog of X Inactivation
JAIN, SANJAY	JOHNS HOPKINS UNIVERSITY	Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection
KIM, DENNIS H (contact) SCHROEDER, FRANK CLEMENS	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Antimicrobial Discovery from Metabolomics of Nematode Pathogen Interactions
LIM, WENDELL A	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells
MCMANUS, MICHAEL T	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Tracing Cell Lineages
MOCARSKI, EDWARD S	EMORY UNIVERSITY	Innate Activation and Death Signals in Health and Disease
RAFII, SHAHIN	WEILL MEDICAL COLL OF CORNELL UNIV	Deciphering Molecular Determinants of Vascular Heterogeneity for Organ Repair
SMITH, STEPHEN J (contact) BURNS, RANDAL	ALLEN INSTITUTE OF BRAIN SCIENCE	Synaptomes of Mouse and Man

2013 NIH Director's Transformative Research Award (R01) (RFA-RM-12-017)

PI Name	Institution Name	Title
CARNES, MOLLY L (contact) DEVINE, PATRICIA G FORD, CECILIA E	UNIVERSITY OF WISCONSIN-MADISON	Exploring the Science of Scientific Review
KORDING, KONRAD P (contact) BOYDEN, EDWARD S CHURCH, GEORGE M	REHABILITATION INSTITUTE OF CHICAGO	Recording Neural Activities onto DNA
MANDEL, GAIL (contact) ADELMAN, JOHN P BREHM, PAUL ROSENTHAL, JOSHUA J C	OREGON HEALTH AND SCI UNIVERSITY	Site-Directed RNA Editing: A New Method to Correct Disease Causing Mutations
OCHOA, AUGUSTO C	LOUISIANA STATE UNIV HSC NEW ORLEANS	Metabolic Approaches to Treat Severe Viral and Inflammatory Diseases
RELMAN, DAVID ARNOLD (contact) HOLMES, SUSAN P	PALO ALTO INSTITUTE FOR RES & EDU, INC.	Predicting Resilience in the Human Microbiome
TING, ALICE Y	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Spatially-Resolved Proteomic Mapping of Living Cells
WANG, LIHONG	WASHINGTON UNIVERSITY	In Vivo Imaging of Single Circulating Cells
WYSSCORAY, TONY (contact) RANDO, THOMAS A	PALO ALTO INSTITUTE FOR RES & EDU, INC.	A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity
YANNOPOULOS, DEMETRI	UNIVERSITY OF MINNESOTA	Reperfusion Injury Protection Strategies during Basic Life Support
YIN, PENG	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Super-Resolution Imaging via Programmable Autonomous Blinking

2012 NIH Director's Transformative Research Award (R01) (RFA-RM-11-006)

PI Name	Institution Name	Title
ABELIOVICH, ASA	COLUMBIA UNIVERSITY HEALTH SCIENCES	Generation and Integration of New CNS Neurons by In Vivo Directed Conversion
ALLISON, DAVID B	UNIVERSITY OF ALABAMA BIRMINGHAM	Energetics, Disparities, & Lifespan: A Unified Hypothesis
ALTSHULER, DAVID (contact) COWAN, CHAD ALBERT	THE BROAD INSTITUTE, INC.	Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
BARRES, BEN A	STANFORD UNIVERSITY	An Astrocytic Basis for Humanity
BLAU, HELEN M	STANFORD UNIVERSITY	Telomere Extension Using Nucleoside-Modified mRNA and Exosomes as a Novel Therape
BROWN, EMERY N (contact) BOYDEN, EDWARD S SOLT, KEN WILSON, MATTHEW A	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Redesigning General Anesthesia
CHRISTMAN, KAREN L (contact) GIANNESCHI, NATHAN CLAUDE	UNIVERSITY OF CALIFORNIA SAN DIEGO	Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
DARNELL, ROBERT B	THE ROCKEFELLER UNIVERSITY	Mapping the Mechanisms of Protein Synthesis-Dependent Synaptic Plasticity
DEISSEROTH, KARL ALEXANDER	STANFORD UNIVERSITY	CLARITY: Fully-Assembled Biology
GEREAU, ROBERT W (contact) BRUCHAS, MICHAEL R ROGERS, JOHN	WASHINGTON UNIVERSITY	Multimodal Biocompatible MicroLED Devices for Diverse Neuroscience Applications
GLASS, CHRISTOPHER K	UNIVERSITY OF CALIFORNIA SAN DIEGO	Enhancer Therapy
MARASCO, PAUL	CLEVELAND VA MEDICAL RESEARCH/ED/FDN	Restoring Upper Limb Movement Sense to Amputees; A Move towards Natural Control of Prosthetic Limbs
NEWMAN, DIANNE K	CALIFORNIA INSTITUTE OF TECHNOLOGY	Geobiological Approaches to Understanding Pulmonary Infections In Situ
SHEA, LONNIE D (contact) BACKMAN, VADIM	NORTHWESTERN UNIVERSITY	An In Vivo Metastasis Sensor
SHEVKOPLYAS, SERGEY S	TULANE UNIVERSITY OF LOUISIANA	Eliminating Mediators of Toxicity from Stored Blood
STOJANOVIC, MILAN N (contact) YAN, HAO	COLUMBIA UNIVERSITY HEALTH SCIENCES	Theranostic Nano-objects: Basic Principles and Initial Applications
TUSCHL, THOMAS (contact) OHLER, UWE PATEL, DINSHAW J	THE ROCKEFELLER UNIVERSITY	Posttranscriptional Regulation by mRNA-Binding Shuttling and Transport Proteins
WEINER, HOWARD L	BRIGHAM AND WOMEN'S HOSPITAL, INC	Role of the Innate Immune System in Aging and Development of Alzheimer's Disease
WISNIEWSKI, NATALIE ANN (contact) MCSHANE, MIKE	PROFUSA, INC.	Implantable Multi-Analyte Sensors for the Continuous Monitoring of Body Chemistries
WUCHERPFENNIG, KAI W (contact) GOTTSCHALK, STEPHEN	DANA-FARBER CANCER INSTITUTE	Reprogramming of T cells for the Treatment of Melanoma

2011 NIH Director's Transformative Research Award (R01) (RFA-RM-10-010)

PI Name	Institution Name	Title
BEN-YAKAR, ADELA (contact) PIERCE-SHIMOMURA, JONATHAN T	UNIVERSITY OF TEXAS AUSTIN	High-Speed Opto-Fluidics to Screen Entire Nervous System in Aging and Disease
BOAHEN, KWABENA	STANFORD UNIVERSITY	Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics
GAGE, FRED H	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits
HARTUNG, THOMAS	JOHNS HOPKINS UNIVERSITY	Mapping the Human Toxome by Systems Toxicology
HONKANEN, RICHARD E	UNIVERSITY OF SOUTH ALABAMA	Methods to Enable Cholesterol Catabolism in Human Monocyte Derived Macrophages
JASANOFF, ALAN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Noninvasive Imaging-Based Electrophysiology Using Microelectronic Devices
KUPPER, THOMAS S CLARK, RACHAEL ANN	BRIGHAM AND WOMEN'S HOSPITAL	Vaccination to Generate Protective Tissue Resident T Cells
LECKMAN, JAMES F (contact) WEXLER, BRUCE E	YALE UNIVERSITY	Integrated Brain, Body and Social Intervention for ADHD
LICHTMAN, JEFF W (contact) MEISTER, MARKUS SANES, JOSHUA R SEUNG, H SEBASTIAN	HARVARD UNIVERSITY	High Resolution Connectomics of Mammalian Neural Circuits
LIN, HENING (contact) CERIONE, RICHARD A WEISS, ROBERT S	CORNELL UNIVERSITY ITHACA	Succinylation and Malonylation as Novel Protein Modifications in Cancer
MCDEVITT, TODD C	GEORGIA INSTITUTE OF TECHNOLOGY	Stem Cell Morphogen Delivery via Engineered Biomaterials
MOOTHA, VAMSI KRISHNA	MASSACHUSETTS GENERAL HOSPITAL	Molecular Prostheses for Mitochondrial Disorders
NIE, SHUMING (contact) SINGHAL, SUNIL	EMORY UNIVERSITY	Contrast-Enhanced and Image-Guided Surgery of Lung Cancer
NOLTA, JAN A	UNIVERSITY OF CALIFORNIA DAVIS	Direct Cell to Cell Transfer of microRNA for Tissue Repair
PAPAVASILIOU, F NINA	ROCKEFELLER UNIVERSITY	Building Novel Vaccines on a Borrowed Coat
PUGLISI, JOSEPH D	STANFORD UNIVERSITY	Single Molecule Translational Profiling
ROSS, MARGARET ELIZABETH (contact) MASON, CHRISTOPHER EDWARD	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Epigenome Interactions in Complex Neurogenetic Disorders

2010 NIH Director's Transformative Research Award (R01) (RFA-RM-09-022)

PI Name	Institution Name	Title
ARLOTTA, PAOLA (contact) JOUNG, J KEITH ZHANG, FENG	MASSACHUSETTS GENERAL HOSPITAL	Genome-Wide Light-Inducible Tuning of Transcriptional Network Dynamic
BLASER, MARTIN J	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Disappearing Gastrointestinal Microbiota in Epidemic Obesity
COUKOS, GEORGE	UNIVERSITY OF PENNSYLVANIA	Transformative Personalized Vascular Disrupting Cancer Immunotherapy
ELLINGTON, ANDREW D	UNIVERSITY OF TEXAS AUSTIN	DNA Circuits for Point-of-Care Diagnostics
FLAVELL, RICHARD A (contact) DHODAPKAR, MADHAV V MANZ, MARKUS G	YALE UNIVERSITY	Understanding Hemotopoietic Neoplasias Using Humanized Mice
GREEN, PAMELA J	UNIVERSITY OF DELAWARE	Global Analysis of the Human RNA Degradome
GRUTZENDLER, JAIME	NORTHWESTERN UNIVERSITY	Embolus Extravasation: An Alternative Mechanism of Microvascular Recanalization
KEATING, AMY E	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Very Large Datasets and New Models to Predict and Design Protein Interactions
NICKELS, BRYCE EDWARD (contact) DOVE, SIMON L	RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK	NanoRNA-Mediated Control of Gene Expression
NICOLELIS, MIGUEL A L	DUKE UNIVERSITY	Dorsal Column Stimulation as a New Therapy for Motor Disorders
OLTZ, EUGENE M (contact) PAYTON, JACQUELINE E	WASHINGTON UNIVERSITY	Targeting Epigenomic Signatures in Non-Hodgkin Lymphoma for Novel Therapeutics
PELTZ, GARY A	STANFORD UNIVERSITY	Human Pharmacogenetics and Human Liver Regeneration
SHAHAM, SHAI	ROCKEFELLER UNIVERSITY	Glial Control of Neuronal Receptive Ending Morphology
WANG, LIGUO	YALE UNIVERSITY	Structure of a Membrane Protein in a Lipid Membrane: Cryo-EM Study of the HCN Cha
WEINER, DAVID B	UNIVERSITY OF PENNSYLVANIA	Development of a Universal Influenza Seasonal Vaccine
WERNIG, MARIUS (contact) SUDHOF, THOMAS C	STANFORD UNIVERSITY	Direct Conversion of Fibroblasts into Neurons: A Novel Approach to Study Neuropsy
YANIK, MEHMET FATIH	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-Throughput In Vivo Subcellular-Resolution Vertebrate Screening Platform
ZADOR, ANTHONY M	COLD SPRING HARBOR LABORATORY	High-Throughput DNA Sequencing Method for Probing the Connectivity of Neural Circ
ZHANG, KANG (contact) DING, SHENG REH, THOMAS A	UNIVERSITY OF CALIFORNIA SAN DIEGO	Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
ZHUANG, XIAOWEI (contact) XIE, XIAOLIANG SUNNEY	HARVARD UNIVERSITY	Dynamic Cellular Architecture of Bacteria by System-Wide Super-Resolution Imaging

2009 NIH Director's Transformative Research Award (R01) (RFA-RM-08-029)

PI Name	Institution Name	Title
AUSUBEL, FREDERICK M	MASSACHUSETTS GENERAL HOSPITAL	Identifying Novel Anti-Infectives by High Through-put Screening in Whole Animals
BRETON, SYLVIE	MASSACHUSETTS GENERAL HOSPITAL	3-Dimensional Modeling of Basal Cell Function in Pseudostratified Epithelia
CAMARERO, JULIO A	UNIVERSITY OF SOUTHERN CALIFORNIA	Cell-Based Screening and Selection of Cyclotide-Based Capture Reagents for Protei
COHEN, PINCHAS	UNIVERSITY OF CALIFORNIA LOS ANGELES	Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease
CRAVATT, BENJAMIN F (contact) KODADEK, THOMAS J	SCRIPPS RESEARCH INSTITUTE	Massively Parallel Identification of Protein Ligands
CZECH, MICHAEL P	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Oral Delivery Vehicles for RNAi Therapies
DANUSER, GAUDENZ (contact) HAHN, KLAUS M	HARVARD MEDICAL SCHOOL	Quantitative Imaging of Signaling Networks
DUBNAU, JOSHUA T	COLD SPRING HARBOR LABORATORY	Genome-Wide Regulatory Network Governing Neuronal mRNA Translation.
FIDOCK, DAVID ARMAND	COLUMBIA UNIVERSITY HEALTH SCIENCES	Exploiting Fatty Acid Metabolism to Cure Malaria
GRIFFITH, LINDA G	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems
HOFFMAN, ANDREW R	PALO ALTO VETERANS INSTIT FOR RESEARCH	Role of Long-Range Chromatin Interactions in Genetic Disease
IYENGAR, SRINIVAS RAVI V HE, JOHN C HONE, JAMES C LOEW, LESLIE M ZAPH, SUSANA NEVES	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	Dynamics Underlying Tissue Integrity
JAFFREY, SAMIE R	WEILL MEDICAL COLL OF CORNELL UNIV	Novel Fluorescent Sensors for Simple, Sensitive, and Specific Protein Detection
JI, RU-RONG (contact) SERHAN, CHARLES NICHOLAS	BRIGHAM AND WOMEN'S HOSPITAL	Resolvins, Protectins, and Chronic Pain Resolution.
KOIDE, SHOHEI	UNIVERSITY OF CHICAGO	Rational Generation of Directed Protein-Capture Reagents
KUO, CALVIN J	STANFORD UNIVERSITY	Three-Dimensional Scaffold-Based Systems for Primary Human Intestinal Culture
LAGASSE, ERIC	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Organogenesis of Ectopic Tissue in Lymph Node
LEE, BRENDAN	BAYLOR COLLEGE OF MEDICINE	Argininosuccinate Lyase Is an Essential Regulator of Systemic Nitric Oxide Produc
LEE, FRANK S	UNIVERSITY OF PENNSYLVANIA	The Hydroxylprolylproteome
LEWIS, KIM	NORTHEASTERN UNIVERSITY	Super-Persistent Cells and the Paradox of Untreatable Infections
LI, LONG-CHENG (contact) LI, HAO	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Transcriptional Activation by Small RNA: Mechanism and Design Rules
LIS, JOHN T (contact) CRAIGHEAD, HAROLD G JIN, MOONSOO M	CORNELL UNIVERSITY	Development of High Throughput Aptamer-based Protein Capture/Detection Assays tow
MACIEJEWSKI, JAROSLAW P	CLEVELAND CLINIC LERNER COM-CWRU	Viral Pathogenesis of Idiopathic Bone Marrow Failure and Immune Cytopenias
MARGOLIS, PETER A (contact) SEID, MICHAEL	CINCINNATI CHILDRENS HOSP MED CTR	Open Source Science: Transforming Chronic Illness Care
MARKOVITZ, DAVID MICHAEL	UNIVERSITY OF MICHIGAN	Replication of Human Endogenous Retroviruses in Modern Humans
MARKOWITZ, SANFORD D	CASE WESTERN RESERVE UNIVERSITY	Identifying Inborn Genetic Susceptibility to Development of Cancer Metastasis
MARSHALL, WALLACE	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Pattern Formation & Regeneration in a Single Cell
MCKNIGHT, STEVEN L (contact) PIEPER, ANDREW A	UT SOUTHWESTERN MEDICAL CENTER	Discovery, Characterization and Preclinical Development of Pro-Neurogenic Drugs
MITRA, PARTHA PRATIM	COLD SPRING HARBOR LABORATORY	The Missing Circuit: The First Brainwide Connectivity Map for Mouse
MURDOCK, DEBORAH G	VANDERBILT UNIVERSITY	Fatty Acid Signals as Quorum Sensing Regulators of Mitochondrial Biogenesis
MURPHY, SHEILA T (contact) BAEZCONDE-GARBANATI, LOURDES ALBERTINA BALL-ROKEACH, SANDRA HAILE, ROBERT WILLIAM	UNIVERSITY OF SOUTHERN CALIFORNIA	Transforming Cancer Knowledge, Attitudes and Behavior through Narrative
NISWENDER, KEVIN D (contact) GALLI, AURELIO	VANDERBILT UNIVERSITY	Insulin Regulation of Monoamine Signaling: Pathway to Obesity
PARSONNET, JULIE	STANFORD UNIVERSITY	Childhood Infection and Prevention of Obesity
POLLACK, GERALD H	UNIVERSITY OF WASHINGTON	Unexpectedly Profound Role of Water in Biology and Medicine
RICE, CHARLES M (contact) BHATIA, SANGEETA N	ROCKEFELLER UNIVERSITY	Modeling Human Hepatotropic Infections in Complex Tissue Organoids
ROBERTS, RICHARD W (contact) SOH, HYONGSOK TOM	UNIVERSITY OF SOUTHERN CALIFORNIA	Polypeptide Design with Proteomic Scope via Microfluidic mRNA Display
SUKI, BELA	BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)	Regulatory Roles of Variable Mechanical Stimuli in Cell Function
TEWARI, MUNEESH	FRED HUTCHINSON CANCER RESEARCH CENTER	RNA as a Hormone: Systemic Signaling in Mammals via Circulating, Cell-Free Small
WALENSKY, LOREN DAVID	DANA-FARBER CANCER INST	A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactom
WILSON, ROBERT B	UNIVERSITY OF PENNSYLVANIA	Random shRNA Selection
WU, JOSEPH C	STANFORD UNIVERSITY	Re-Education of the Immune System for hES Cell Tolerance
XIE, XIAOLIANG SUNNEY	HARVARD UNIVERSITY	Imaging the Invisible with No Labels: A Major Opportunity in Biology and Medicine
ZYLKA, MARK J	UNIV OF NORTH CAROLINA CHAPEL HILL	Harnessing Ectonucleotidases to Treat Chronic Pain