Part of the High-Risk, High-Reward Research program, the award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.
- Open to all career stages
- Open to individuals or teams
- No preliminary data required
- Research effort commensurate to project needs
- Anonymized review process
- Flexible budgets
- No prior approval required for large budget requests
The NIH Director’s Transformative Research Award (R01 mechanism), established in 2009, supports exceptionally innovative and/or unconventional research projects with the potential to create or overturn fundamental paradigms. Multiple Principal Investigators and large budget applications are welcome. Though the application uses the standard R01 application, the requested information is very different from the standard R01. No detailed experimental plan or preliminary data are required. In the “Research Strategy” component, the investigators are asked to describe the challenge or problem being addressed, why it is important, and why the proposed approaches to addressing this major challenge or problem are unusually innovative. In addition, the investigators are asked to use the “Specific Aims” component to distill their proposal into a one-page summary in which they explicitly address the challenge, innovation, and impact of what they propose and the rationale of their approach.
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Applications due September 1, 2023