Skip to main content
NIH Director's Transformative Research Award logo.

Program Publications

Publications Search by Program

Search Result

The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Author Journal Name PubMedID Journal Abbreviation Publication Date PubMedLink
Quantitative Mass Spectrometry Imaging of Intact Proteins in Tissues. Iqfath M, Swansiger AK, Yang M, Miller L, Moore AM, Hernly E, Bai Y, Zhang ZY, Prell JS, Laskin J Analytical chemistry 41538409 Anal Chem 2026 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/41538409
Increasing Proteome Coverage Through a Reduction in Analyte Complexity in Single-Cell Equivalent Samples. Pang M, Jones JJ, Wang TY, Quan B, Kubat NJ, Qiu Y, Roukes ML, Chou TF Journal of proteome research 38832920 J Proteome Res 2025 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/38832920
Molecularly-guided spatial proteomics captures single-cell identity and heterogeneity of the nervous system. Dutta S, Pang M, Coughlin GM, Gudavalli S, Roukes ML, Chou TF, Gradinaru V bioRxiv : the preprint server for biology 39990460 bioRxiv 2025 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/39990460
Nanomechanical mass measurements through feature-based time series clustering. Neumann AP, Gomez A, Nunn AR, Sader JE, Roukes ML The Review of scientific instruments 38341716 Rev Sci Instrum 2024 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/38341716
A Hybrid Orbitrap-Nanoelectromechanical Systems Approach for the Analysis of Individual, Intact Proteins in Real Time. Neumann AP, Sage E, Boll D, Reinhardt-Szyba M, Fon W, Masselon C, Hentz S, Sader JE, Makarov A, Roukes ML Angewandte Chemie (International ed. in English) 38769756 Angew Chem Int Ed Engl 2024 Aug 12 https://www.ncbi.nlm.nih.gov/pubmed/38769756
Pneumatically Assisted Microfluidic Probe for Enhanced Mass Spectrometry Imaging Performance. Jiang LX, Laskin J Journal of the American Society for Mass Spectrometry 40116008 J Am Soc Mass Spectrom 2025 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/40116008
Data-driven fingerprint nanoelectromechanical mass spectrometry. Sader JE, Gomez A, Neumann AP, Nunn A, Roukes ML Nature communications 39438454 Nat Commun 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/39438454
Assessing the Validity of the Ask Suicide-Screening Questions in Black Youth. Horowitz LM, Mournet AM, Sheftall A, He JP, Lowry NJ, Aguinaldo LD, Sullivant SA, Wharff EA, Merikangas KR, Pao M, Bridge JA Journal of the Academy of Consultation-Liaison Psychiatry 36273745 J Acad Consult Liaison Psychiatry 2023 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/36273745
National Trends in Suicide Among Asian American or Pacific Islander Youth. Keum BT, Oh S, Sheftall AH JAMA network open 39052296 JAMA Netw Open 2024 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/39052296
Alterations in performance and discriminating power of the death/suicide implicit association test across the lifespan. Ruch DA, Bridge JA, Tissue J, Madden SP, Galfavy H, Gorlyn M, Sheftall AH, Szanto K, Keilp JG Psychiatry research 38492262 Psychiatry Res 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38492262
Entrapment and social problem-solving in suicidal behavior across the adult lifespan. Wang C, Keilp JG, Galfalvy H, Bridge JA, Sheftall AH, Szanto K Journal of affective disorders 36842650 J Affect Disord 2023 May 15 https://www.ncbi.nlm.nih.gov/pubmed/36842650
Preteen Suicide Risk Screening in the Pediatric Outpatient Setting: A Clinical Pathway. Hennefield L, Denton EG, Chen PG, Sheftall AH, Ayer L Journal of the Academy of Consultation-Liaison Psychiatry 38908827 J Acad Consult Liaison Psychiatry 2024 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/38908827
Longitudinal trajectories of suicidal ideation among child welfare-involved 7- to 12-year-old children. Ayer L, Hassler G, Ohana E, Sheftall AH, Anderson NW, Griffin BA Journal of child psychology and psychiatry, and allied disciplines 38659338 J Child Psychol Psychiatry 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/38659338
Understanding of death and related constructs in children with suicidal thoughts and behaviors: A review and future directions. Ortin-Peralta A, Hennefield L, Eichenbaum M, Espinosa-Polanco M, Sheftall AH Clinical child psychology and psychiatry 39825789 Clin Child Psychol Psychiatry 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/39825789
Anticipated Discrimination and Suicidal Behaviors Among Black Gay and Bisexual Male Adolescents: The Moderating Role of Developmental Assets. Boyd DT, Sheftall AH Research square 41646393 Res Sq 2026 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/41646393
Understanding suicidal thoughts and behaviors in Black youth within the child welfare system: An exploration of protective factors. Sheftall AH, Picou PN, Ohana E, Hassler G, Griffin BA, Ayer L Child abuse & neglect 41172767 Child Abuse Negl 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41172767
School Connectedness and Suicidal Ideation Among Black Youth: A Latent Class Analysis. Harrell DR, Richardson SC, Sheftall AH School mental health 41403887 School Ment Health 2025 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/41403887
Neurocognitive and clinical characteristics of elementary school-aged children with a history of suicidal thoughts and behaviors. Chen Q, Armstrong SE, Vakil F, Bridge JA, Keilp JG, Sheftall AH Journal of affective disorders 37442443 J Affect Disord 2023 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/37442443
Severity and Transition of Suicidal Behaviors in Childhood: Sex, Racial, and Ethnic Differences in the Adolescent Brain Cognitive Development (ABCD) Study. Ortin-Peralta A, Sheftall AH, Osborn A, Miranda R The Journal of adolescent health : official publication of the Society for Adolescent Medicine 37389520 J Adolesc Health 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37389520
The valine-arginine dipeptide repeat protein encoded by mammalian telomeric RNA appears highly expressed in mitosis and may repress global translation. Al-Turki TM, Mantri V, Willcox S, Mills CA, Herring LE, Cho SJ, Lee H, Meyer C, Anton ES, Griffith JD bioRxiv : the preprint server for biology 39211251 bioRxiv 2024 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/39211251
Ultrastructural reconstruction of the endodermal nerve net of Hydra vulgaris. Zhang S, Ofer N, Dupre C, Wang X, Schalek R, Wu Y, Lin M, Roth M, Adhinarta J, Gohain A, Fan Y, Yin W, Wei D, Lichtman J, Yuste R Current biology : CB 41167196 Curr Biol 2025 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/41167196
The telomeric valine-arginine dipeptide repeat protein changes state to diffuse staining in mitosis and represses in vitro translation. Al-Turki T, Mantri V, Willcox S, Mills CA, Herring LE, Cho SJ, Lee H, Meyer C, Anton ES, Griffith JD Proceedings of the National Academy of Sciences of the United States of America 41269794 Proc Natl Acad Sci U S A 2025 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/41269794
Radial glia promote microglial development through integrin α(V)β(8) -TGFβ1 signaling. McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD bioRxiv : the preprint server for biology 37790363 bioRxiv 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37790363
Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex. Wu JY, Cho SJ, Descant K, Li PH, Shapson-Coe A, Januszewski M, Berger DR, Meyer C, Casingal C, Huda A, Liu J, Ghashghaei T, Brenman M, Jiang M, Scarborough J, Pope A, Jain V, Stein JL, Guo J, Yasuda R, Lichtman JW, Anton ES Neuron 37898123 Neuron 2024 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/37898123
The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL Immunity 30389415 Immunity 2018 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/30389415
NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL Journal of biomolecular NMR 30815789 J Biomol NMR 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30815789
TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells. Yoshizawa A, Bi K, Keskin DB, Zhang G, Reinhold B, Reinherz EL European journal of immunology 28872670 Eur J Immunol 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28872670
αβ T Cell Receptor Mechanosensing Forces out Serial Engagement. Feng Y, Reinherz EL, Lang MJ Trends in immunology 30060805 Trends Immunol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30060805
The Gene Conundrum in Alzheimer's Disease. Chun J Cerebrum : the Dana forum on brain science 32206173 Cerebrum 2019 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/32206173
Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer's Disease. Kaeser GE, Chun J Frontiers in genetics 32457796 Front Genet 2020 https://www.ncbi.nlm.nih.gov/pubmed/32457796
Brain cell somatic gene recombination and its phylogenetic foundations. Kaeser G, Chun J The Journal of biological chemistry 32699111 J Biol Chem 2020 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/32699111
Reply to: APP gene copy number changes reflect exogenous contamination. Lee MH, Liu CS, Zhu Y, Kaeser GE, Rivera R, Romanow WJ, Kihara Y, Chun J Nature 32814882 Nature 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32814882
Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Sidhwani P, Leerberg DM, Boezio GLM, Capasso TL, Yang H, Chi NC, Roman BL, Stainier DYR, Yelon D Development (Cambridge, England) 32439760 Development 2020 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/32439760
The African Turquoise Killifish: A Scalable Vertebrate Model for Aging and Other Complex Phenotypes. Boos F, Chen J, Brunet A Cold Spring Harbor protocols 37100468 Cold Spring Harb Protoc 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/37100468
Tutorial: practical considerations for tissue clearing and imaging. Weiss KR, Voigt FF, Shepherd DP, Huisken J Nature protocols 34021294 Nat Protoc 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34021294
Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. Sahai-Hernandez P, Pouget C, Eyal S, Svoboda O, Chacon J, Grimm L, Gjøen T, Traver D eLife 37695317 Elife 2023 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/37695317
Drivers of vessel progenitor fate define intermediate mesoderm dimensions by inhibiting kidney progenitor specification. Perens EA, Yelon D Developmental biology 39307382 Dev Biol 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39307382
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK Cell 36754049 Cell 2023 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/36754049
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS. Linares GR, Li Y, Chang WH, Rubin-Sigler J, Mendonca S, Hong S, Eoh Y, Guo W, Huang YH, Chang J, Tu S, Dorjsuren N, Santana M, Hung ST, Yu J, Perez J, Chickering M, Cheng TY, Huang CC, Lee SJ, Deng HJ, Bach KT, Gray K, Subramanyam V, Rosenfeld J, Alworth SV, Goodarzi H, Ichida JK Cell stem cell 36736291 Cell Stem Cell 2023 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/36736291
CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology. Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, Anderson EN, Asin J, Ichida JK, Pandey UB, Wolin SL, Stupp SI, Kiskinis E Science advances 37948524 Sci Adv 2023 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/37948524
Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases. Zhang S, Shu H, Zhou J, Rubin-Sigler J, Yang X, Liu Y, Cooper-Knock J, Monte E, Zhu C, Tu S, Li H, Tong M, Ecker JR, Ichida JK, Shen Y, Zeng J, Tsao PS, Snyder MP bioRxiv : the preprint server for biology 38798507 bioRxiv 2024 May 14 https://www.ncbi.nlm.nih.gov/pubmed/38798507
Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS. Zhang S, Moll T, Rubin-Sigler J, Tu S, Li S, Yuan E, Liu M, King M, Alhathli E, Treanor C, Twelvetrees A, Weinreich M, Bonsall S, Harvey C, Gornall S, Shaw A, Ganssauge J, Bhinge A, Souza CDS, Ferraiuolo L, Hornstein E, Shalem O, Avila A, Shelkovnikova T, van Dijk CH, Timpanaro IS, Kenna KP, Zeng J, van Damme P, Tsao PS, Shaw PJ, Ichida JK, Cooper-Knock J, Snyder MP medRxiv : the preprint server for health sciences 38633814 medRxiv 2025 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/38633814
Stem cell therapy for central nervous system disorders: Metabolic interactions between transplanted cells and local microenvironments. Sakowski SA, Chen KS Neurobiology of disease 35988874 Neurobiol Dis 2022 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/35988874
Occupational history associates with ALS survival and onset segment. Goutman SA, Boss J, Godwin C, Mukherjee B, Feldman EL, Batterman SA Amyotrophic lateral sclerosis & frontotemporal degeneration 36193557 Amyotroph Lateral Scler Frontotemporal Degener 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36193557
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL The Lancet. Neurology 35334234 Lancet Neurol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35334234
Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. Goutman SA, Boss J, Jang DG, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman EL, Batterman SA Journal of the neurological sciences 38278093 J Neurol Sci 2024 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/38278093
Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions. Sakowski SA, Koubek EJ, Chen KS, Goutman SA, Feldman EL Annals of neurology 38411261 Ann Neurol 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38411261
Residential exposure associations with ALS risk, survival, and phenotype: a Michigan-based case-control study. Goutman SA, Boss J, Jang DG, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman EL, Batterman SA Amyotrophic lateral sclerosis & frontotemporal degeneration 38557405 Amyotroph Lateral Scler Frontotemporal Degener 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38557405
Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study. Jang DG, Dou JF, Koubek EJ, Teener S, Zhou L, Bakulski KM, Mukherjee B, Batterman SA, Feldman EL, Goutman SA Journal of neurology, neurosurgery, and psychiatry 39107037 J Neurol Neurosurg Psychiatry 2025 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/39107037
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. Jin W, Boss J, Bakulski KM, Goutman SA, Feldman EL, Fritsche LG, Mukherjee B Journal of neurology 39249108 J Neurol 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39249108
Gene expression signatures from whole blood predict amyotrophic lateral sclerosis case status and survival. Zhao Y, Savelieff MG, Li X, Guo K, Wang K, Li M, Li B, Iyer G, Sakowski SA, Zhao L, Teener SJ, Bakulski KM, Dou JF, Traynor BJ, Karnovsky A, Batterman SA, Hur J, Goutman SA, Sartor MA, Feldman EL Nature communications 41173979 Nat Commun 2025 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/41173979
The amyotrophic lateral sclerosis exposome: recent advances and future directions. Goutman SA, Savelieff MG, Jang DG, Hur J, Feldman EL Nature reviews. Neurology 37709948 Nat Rev Neurol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37709948
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Goutman SA, Boss J, Jang DG, Mukherjee B, Richardson RJ, Batterman S, Feldman EL Journal of neurology, neurosurgery, and psychiatry 37758454 J Neurol Neurosurg Psychiatry 2024 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/37758454
Nanoplastics and Neurodegeneration in ALS. Eisen A, Pioro EP, Goutman SA, Kiernan MC Brain sciences 38790450 Brain Sci 2024 May 7 https://www.ncbi.nlm.nih.gov/pubmed/38790450
Cumulative Genetic Score and C9orf72 Repeat Status Independently Contribute to Amyotrophic Lateral Sclerosis Risk in 2 Case-Control Studies. Dou J, Bakulski K, Guo K, Hur J, Zhao L, Saez-Atienzar S, Stark A, Chia R, García-Redondo A, Rojas-Garcia R, Vázquez Costa JF, Fernandez Santiago R, Bandres-Ciga S, Gómez-Garre P, Periñán MT, Mir P, Pérez-Tur J, Cardona F, Menendez-Gonzalez M, Riancho J, Borrego-Hernández D, Galán-Dávila L, Infante Ceberio J, Pastor P, Paradas C, Dols-Icardo O, Traynor BJ, Feldman EL, Goutman SA, Spanish Neurological Consortium Neurology. Genetics 37293291 Neurol Genet 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37293291
miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis. Hur J, Paez-Colasante X, Figueroa-Romero C, Lo TW, Barmada SJ, Paulsen MT, Ljungman M, Alakwaa FM, Savelieff MG, Goutman SA, Feldman EL Human molecular genetics 36219176 Hum Mol Genet 2023 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/36219176
Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles. Goutman SA, Boss J, Iyer G, Habra H, Savelieff MG, Karnovsky A, Mukherjee B, Feldman EL Muscle & nerve 36321729 Muscle Nerve 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36321729
Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Goutman SA, Hardiman O, Al-Chalabi A, Chió A, Savelieff MG, Kiernan MC, Feldman EL The Lancet. Neurology 35334233 Lancet Neurol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35334233
Variable selection with multiply-imputed datasets: choosing between stacked and grouped methods. Du J, Boss J, Han P, Beesley LJ, Kleinsasser M, Goutman SA, Batterman S, Feldman EL, Mukherjee B Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America 36644406 J Comput Graph Stat 2022 https://www.ncbi.nlm.nih.gov/pubmed/36644406
Peripheral Immune Profiles Predict ALS Progression in an Age- and Sex-Dependent Manner. Murdock BJ, Zhao B, Pawlowski KD, Famie JP, Piecuch CE, Webber-Davis IF, Teener SJ, Feldman EL, Zhao L, Goutman SA Neurology(R) neuroimmunology & neuroinflammation 38626361 Neurol Neuroimmunol Neuroinflamm 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38626361
Life Course Exposure to Cyanobacteria and Amyotrophic Lateral Sclerosis Survival. Batterman SA, Islam MK, Jang DG, Feldman EL, Goutman SA International journal of environmental research and public health 40427878 Int J Environ Res Public Health 2025 May 12 https://www.ncbi.nlm.nih.gov/pubmed/40427878
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics. Murdock BJ, Park J, Jang DG, Zhao B, Teener SJ, Webber-Davis IF, Zhao L, Feldman EL, Goutman SA Annals of clinical and translational neurology 40629698 Ann Clin Transl Neurol 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40629698
Awareness and care practices for rare neurologic diseases among senior neurologists: A global survey. Jang DG, Federico A, Savelieff MG, Grisold W, Mancuso M, Molnar MJ, Feldman EL, Reynolds EL, World Federation of Neurology Subspecialist Group on Rare Neurologic Diseases Journal of the neurological sciences 39855013 J Neurol Sci 2025 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/39855013
Natural Killer Cell Dysregulation During ALS Disease Progression: A Gene Expression Analysis. Goutman SA, Guo K, Park J, Jang DG, Teener SJ, Webber-Davis IF, Famie JP, Piecuch CE, Hur J, Murdock BJ Neurology open access 41684905 Neurol Open Access 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41684905
Development of Life Course Exposure Estimates Using Geospatial Data and Residence History. Batterman S, Islam MK, Goutman S International journal of environmental research and public health 41302575 Int J Environ Res Public Health 2025 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/41302575
Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study. Jang DG, Dou J, Koubek EJ, Teener S, Zhao L, Bakulski KM, Mukherjee B, Batterman SA, Feldman EL, Goutman SA medRxiv : the preprint server for health sciences 38464233 medRxiv 2024 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/38464233
Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis. Guo K, Figueroa-Romero C, Noureldein MH, Murdock BJ, Savelieff MG, Hur J, Goutman SA, Feldman EL Brain : a journal of neurology 37721161 Brain 2024 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/37721161
Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank. Jin W, Boss J, Bakulski KM, Goutman SA, Feldman EL, Fritsche LG, Mukherjee B medRxiv : the preprint server for health sciences 38585910 medRxiv 2024 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/38585910
Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations. Quigley SE, Quigg KH, Goutman SA CNS drugs 40897992 CNS Drugs 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40897992
Impact of the Adverse Social Exposome on Survival in Individuals With Amyotrophic Lateral Sclerosis. Jang DG, Kind AJ, Patterson A, Pedde M, Powell WR, Feldman EL, Goutman SA Neurology 39879575 Neurology 2025 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/39879575
Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis. Zhao Y, Li X, Wang K, Iyer G, Sakowski SA, Zhao L, Teener S, Bakulski KM, Dou JF, Traynor BJ, Karnovsky A, Batterman SA, Feldman EL, Sartor MA, Goutman SA EBioMedicine 39369616 EBioMedicine 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39369616
Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival. Goutman SA, Stouffer DG, Jang DG, Park J, Murdock BJ, Auchus RJ Annals of clinical and translational neurology 41412960 Ann Clin Transl Neurol 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41412960
Amyotrophic lateral sclerosis. Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, Sobue G Lancet (London, England) 36116464 Lancet 2022 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/36116464
Priorities and Recommendations to Make ALS a Livable Disease Emanating from the 2024 National Academies of Sciences, Engineering, and Medicine Report Living with ALS. Howard IM, Babu S, Carter C, Sakowski SA, Kurent JE, Cudkowicz ME, Feldman EL Annals of neurology 39390661 Ann Neurol 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39390661
Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism. Guo K, Savelieff MG, Jang DG, Teener SJ, Zhao L, Hur J, Goutman SA, Feldman EL Annals of neurology 39976286 Ann Neurol 2025 Jul https://www.ncbi.nlm.nih.gov/pubmed/39976286
Human microglial state dynamics in Alzheimer's disease progression. Sun N, Victor MB, Park YP, Xiong X, Scannail AN, Leary N, Prosper S, Viswanathan S, Luna X, Boix CA, James BT, Tanigawa Y, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai LH, Kellis M Cell 37774678 Cell 2023 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/37774678
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion. Xiong X, James BT, Boix CA, Park YP, Galani K, Victor MB, Sun N, Hou L, Ho LL, Mantero J, Scannail AN, Dileep V, Dong W, Mathys H, Bennett DA, Tsai LH, Kellis M Cell 37774680 Cell 2023 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/37774680
Single-cell multiregion dissection of Alzheimer's disease. Mathys H, Boix CA, Akay LA, Xia Z, Davila-Velderrain J, Ng AP, Jiang X, Abdelhady G, Galani K, Mantero J, Band N, James BT, Babu S, Galiana-Melendez F, Louderback K, Prokopenko D, Tanzi RE, Bennett DA, Tsai LH, Kellis M Nature 39048816 Nature 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/39048816
Integrated multimodal cell atlas of Alzheimer's disease. Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Agrawal A, Kana O, Zhen X, Barlow ST, Brouner K, Campos J, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Cool J, Dalley R, Darvas M, Ding SL, Dolbeare T, Egdorf T, Esposito L, Ferrer R, Fleckenstein LE, Gala R, Gary A, Gelfand E, Gloe J, Guilford N, Guzman J, Hirschstein D, Ho W, Hupp M, Jarsky T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore MD, Kirkland A, Kunst M, Lee BR, Leytze M, Mac Donald CL, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Mena G, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus JK, Olsen PA, Pacleb M, Pagan CM, Peña N, Pham T, Pom CA, Postupna N, Rimorin C, Ruiz A, Saldi GA, Schantz AM, Shapovalova NV, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting JT, Torkelson A, Tran T, Valera Cuevas NJ, Walling-Bell S, Wang MQ, Waters J, Wilson AM, Xiao M, Haynor D, Gatto NM, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith KA, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES Nature neuroscience 39402379 Nat Neurosci 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39402379
Multifaceted impact of specialized neuropeptide-intensive neurons on the selective vulnerability in Alzheimer's disease. Li M, Flack N, Larsen PA bioRxiv : the preprint server for biology 38014130 bioRxiv 2024 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/38014130
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. Aikio M, Odeh HM, Wobst HJ, Lee BL, Chan Ú, Mauna JC, Mack KL, Class B, Ollerhead TA, Ford AF, Barbieri EM, Cupo RR, Drake LE, Smalley JL, Lin YT, Lam S, Thomas R, Castello N, Baral A, Beyer JN, Najar MA, Dunlop J, Gitler AD, Javaherian A, Kaye JA, Burslem GM, Brown DG, Donnelly CJ, Finkbeiner S, Moss SJ, Brandon NJ, Shorter J Cell reports 39817908 Cell Rep 2025 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/39817908
Integrating single-cell RNA-seq datasets with substantial batch effects. Hrovatin K, Moinfar AA, Zappia L, Lapuerta AT, Lengerich B, Kellis M, Theis FJ bioRxiv : the preprint server for biology 37961672 bioRxiv 2024 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/37961672
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology. Mathys H, Peng Z, Boix CA, Victor MB, Leary N, Babu S, Abdelhady G, Jiang X, Ng AP, Ghafari K, Kunisky AK, Mantero J, Galani K, Lohia VN, Fortier GE, Lotfi Y, Ivey J, Brown HP, Patel PR, Chakraborty N, Beaudway JI, Imhoff EJ, Keeler CF, McChesney MM, Patel HH, Patel SP, Thai MT, Bennett DA, Kellis M, Tsai LH Cell 37774677 Cell 2023 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/37774677
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease. Sun N, Akay LA, Murdock MH, Park Y, Galiana-Melendez F, Bubnys A, Galani K, Mathys H, Jiang X, Ng AP, Bennett DA, Tsai LH, Kellis M Nature neuroscience 37264161 Nat Neurosci 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37264161
CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function. Xie L, Merjane J, Bergmann CA, Xu J, Hurtle B, Donnelly CJ bioRxiv : the preprint server for biology 39026766 bioRxiv 2024 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/39026766
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience. Liu Z, Zhang S, James BT, Galani K, Mangan RJ, Fass SB, Liang C, Wagle MM, Boix CA, Tanigawa Y, Yun S, Sung Y, Xiong X, Sun N, Hou L, Wohlwend M, Qiu M, Han X, Xiong L, Preka E, Huang L, Li WF, Ho LL, Grayson A, Mantero J, Kozlenkov A, Mathys H, Chen T, Dracheva S, Bennett DA, Tsai LH, Kellis M Cell 40752494 Cell 2025 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/40752494
Hypometric genetics: Improved power in genetic discovery by incorporating quality control flags. Tanigawa Y, Kellis M American journal of human genetics 39442521 Am J Hum Genet 2024 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/39442521
High cell-type specificity of eQTLs revealed by single-nucleus analyses of brain and blood. Vochteloo M, Kooijmans A, Bakker J, Oelen R, Niewold J, Kaptijn D, Bonder MJ, van der Wijst M, Huang Y, Bryois J, Tsai EA, Franke L, Westra HJ bioRxiv : the preprint server for biology 41394650 bioRxiv 2025 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/41394650
Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD. Pineda SS, Lee H, Ulloa-Navas MJ, Linville RM, Garcia FJ, Galani K, Engelberg-Cook E, Castanedes MC, Fitzwalter BE, Pregent LJ, Gardashli ME, DeTure M, Vera-Garcia DV, Hucke ATS, Oskarsson BE, Murray ME, Dickson DW, Heiman M, Belzil VV, Kellis M Cell 38521060 Cell 2024 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/38521060
TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. Russo MN, Norton ES, Ulloa-Navas MJ, Zarco N, Wang W, Lam TT, Quiñones-Hinojosa A, Belzil VV, Guerrero-Cázares H Journal of extracellular vesicles 40985879 J Extracell Vesicles 2025 Sep https://www.ncbi.nlm.nih.gov/pubmed/40985879
Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD. Xie L, Zhu Y, Hurtle BT, Wright M, Robinson JL, Mauna JC, Brown EE, Ngo M, Bergmann CA, Xu J, Merjane J, Gleixner AM, Grigorean G, Liu F, Rossoll W, Lee EB, Kiskinis E, Chikina M, Donnelly CJ bioRxiv : the preprint server for biology 40291645 bioRxiv 2025 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/40291645
A polygenic score method boosted by non-additive models. Ohta R, Tanigawa Y, Suzuki Y, Kellis M, Morishita S Nature communications 38811555 Nat Commun 2024 May 29 https://www.ncbi.nlm.nih.gov/pubmed/38811555
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. Guo L, Mann JR, Mauna JC, Copley KE, Wang H, Rubien JD, Bergmann CA, Carey JL, Merjane J, Ngo M, Xu J, Odeh HM, Lin J, Lee BL, Ganser L, Robinson E, Kim KM, Murthy AC, Paul T, Portz B, Gleixner AM, Diaz Z, Smirnov A, Padilla G, Lavorando E, Espy C, Shang Y, Huang EJ, Chesi A, Fawzi NL, Myong S, Donnelly CJ, Shorter J Molecular cell 41512823 Mol Cell 2026 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/41512823
Local translation in primary afferents and its contribution to pain. Gale JR, Gedeon JY, Donnelly CJ, Gold MS Pain 35438669 Pain 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/35438669
Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease. Li B, Wang S, Kerman B, Hugo C, Shwab EK, Shu C, Chiba-Falek O, Arvanitakis Z, N Yassine H Aging cell 40790613 Aging Cell 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40790613
Novel Kinesin Family Member 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal Transactive Response DNA Binding Protein 43 kDa Interactions and Dendritic Atrophy. Homayoun H, DeChellis-Marks MR, Kofler J, Fricklas G, Gleixner AM, Yeh FC, Lacomis D, Chu CT, Donnelly CJ The American journal of pathology 40543705 Am J Pathol 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/40543705
Assays to measure small molecule Hsp70 agonist activity in vitro and in vivo. Shapiro O, Woods C, Gleixner AM, Sannino S, Ngo M, McDaniels MD, Wipf P, Hukriede NA, Donnelly CJ, Brodsky JL Analytical biochemistry 39522672 Anal Biochem 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39522672
Multifaceted Role of Specialized Neuropeptide-Intensive Neurons on the Selective Vulnerability to Alzheimer's Disease in the Human Brain. Li M, Flack N, Larsen PA Biomolecules 39766225 Biomolecules 2024 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/39766225
Disrupting pathologic phase transitions in neurodegeneration. Hurtle BT, Xie L, Donnelly CJ The Journal of clinical investigation 37395272 J Clin Invest 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/37395272
Power of inclusion: Enhancing polygenic prediction with admixed individuals. Tanigawa Y, Kellis M American journal of human genetics 37890495 Am J Hum Genet 2023 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/37890495
Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease. Linna-Kuosmanen S, Schmauch E, Galani K, Ojanen J, Boix CA, Örd T, Toropainen A, Singha PK, Moreau PR, Harju K, Blazeski A, Segerstolpe Å, Lahtinen V, Hou L, Kang K, Meibalan E, Agudelo LZ, Kokki H, Halonen J, Jalkanen J, Gunn J, MacRae CA, Hollmén M, Hartikainen JEK, Kaikkonen MU, García-Cardeña G, Tavi P, Kiviniemi T, Kellis M Cell reports. Medicine 38776872 Cell Rep Med 2024 May 21 https://www.ncbi.nlm.nih.gov/pubmed/38776872
TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS. Alessandrini F, Wright M, Kurosaki T, Perloff OS, Ngo M, Kofler JK, Donnelly CJ, Maquat LE, Kiskinis E Neuron 41389796 Neuron 2026 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/41389796
PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores. Tian X, Fabiha T, Li WF, Dey KK, Kellis M, Tanigawa Y bioRxiv : the preprint server for biology 41292742 bioRxiv 2025 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/41292742
sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer's disease pathology. Rao I, Kellis M, Tanigawa Y bioRxiv : the preprint server for biology 41332677 bioRxiv 2025 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/41332677
Autophagy at the synapse, an early site of dysfunction in neurodegeneration. Jasutkar HG, Yamamoto A Current opinion in physiology 36968133 Curr Opin Physiol 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36968133
Phase Separation in Biology and Disease; Current Perspectives and Open Questions. Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea DM, Mueller-Cajar O, Portz B, Reilly JF, Reinkemeier CD, Sabari BR, Sanulli S, Shorter J, Sontag E, Strader L, Stachowiak J, Weber SC, White M, Zhang H, Zweckstetter M, Elbaum-Garfinkle S, Kriwacki R Journal of molecular biology 36690068 J Mol Biol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36690068
The environmental stress response regulates ribosome content in cell cycle-arrested S. cerevisiae. Terhorst A, Sandikci A, Whittaker CA, Szórádi T, Holt LJ, Neurohr GE, Amon A Frontiers in cell and developmental biology 37123399 Front Cell Dev Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/37123399
Condensation of LINE-1 is critical for retrotransposition. Sil S, Keegan S, Ettefa F, Denes LT, Boeke JD, Holt LJ eLife 37114770 Elife 2023 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/37114770
Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis. Waldron FM, Spence H, Taso OS, Read FL, Sinha IR, Irwin KE, Wong PC, Ling JP, Gregory JM bioRxiv : the preprint server for biology 41256466 bioRxiv 2025 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/41256466
Skin TDP-43 pathology as a candidate biomarker for predicting amyotrophic lateral sclerosis decades prior to motor symptom onset. Waldron FM, Langerová T, Rahmanova A, Read FL, Spence H, Roberts K, Macleod AD, Pattle SB, Hanna K, Gregory JM bioRxiv : the preprint server for biology 41256495 bioRxiv 2025 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/41256495
Single-molecule validation and optimised protocols for the use of secondary nanobodies in multiplexed immunoassays. Saleeb R, O'Shaughnessy J, Ferguson R, Adams CT, Horrocks MH Journal of microscopy 41563121 J Microsc 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41563121
Polysome collapse and RNA condensation fluidize the cytoplasm. Xie Y, Shu T, Liu T, Spindler MC, Mahamid J, Hocky GM, Gresham D, Holt LJ Molecular cell 39059370 Mol Cell 2024 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/39059370
The broken Alzheimer's disease genome. Gouveia Roque C, Phatnani H, Hengst U Cell genomics 38697121 Cell Genom 2024 May 8 https://www.ncbi.nlm.nih.gov/pubmed/38697121
Macromolecular crowding: Sensing without a sensor. Holt LJ, Delarue M Current opinion in cell biology 37897928 Curr Opin Cell Biol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37897928
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons. Sinha IR, Sandal PS, Spence H, Burns GD, Mallika AP, Abbasinejad F, Irwin KE, Cruz ALF, Wang V, Marx SR, Rodríguez JL, Langmead B, Gregory JM, Wong PC, Ling JP Nature communications 40715064 Nat Commun 2025 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/40715064
Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions. Devany J, Falk MJ, Holt LJ, Murugan A, Gardel ML Developmental cell 37339629 Dev Cell 2023 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/37339629
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. Shi J, Wu X, Wang Z, Li F, Meng Y, Moore RM, Cui J, Xue C, Croce KR, Yurdagul A Jr, Doench JG, Li W, Zarbalis KS, Tabas I, Yamamoto A, Zhang H Nature communications 36566259 Nat Commun 2022 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/36566259
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS. Spence H, Waldron FM, Saleeb RS, Brown AL, Rifai OM, Gilodi M, Read F, Roberts K, Milne G, Wilkinson D, O'Shaughnessy J, Pastore A, Fratta P, Shneider N, Tartaglia GG, Zacco E, Horrocks MH, Gregory JM Acta neuropathologica 38443601 Acta Neuropathol 2024 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/38443601
Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells. Valverde-Mendez D, Sunol AM, Bratton BP, Delarue M, Hofmann JL, Sheehan JP, Gitai Z, Holt LJ, Shaevitz JW, Zia RN Proceedings of the National Academy of Sciences of the United States of America 39854229 Proc Natl Acad Sci U S A 2025 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/39854229
mRNA condensation fluidizes the cytoplasm. Xie Y, Liu T, Gresham D, Holt LJ bioRxiv : the preprint server for biology 37398029 bioRxiv 2023 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/37398029
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts. Rifai OM, O'Shaughnessy J, Dando OR, Munro AF, Sewell MDE, Abrahams S, Waldron FM, Sibley CR, Gregory JM Brain : a journal of neurology 37450566 Brain 2023 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/37450566
Macromolecular crowding limits growth under pressure. Alric B, Formosa-Dague C, Dague E, Holt LJ, Delarue M Nature physics 37152719 Nat Phys 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/37152719
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates. Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH Science advances 37967183 Sci Adv 2023 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/37967183
Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding. Sang D, Shu T, Pantoja CF, Ibáñez de Opakua A, Zweckstetter M, Holt LJ Molecular cell 36108633 Mol Cell 2022 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/36108633
Increased mesoscale diffusivity in response to acute glucose starvation. Xie Y, Gresham D, Holt L bioRxiv : the preprint server for biology 36711511 bioRxiv 2023 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/36711511
How it feels in a cell. Bonucci M, Shu T, Holt LJ Trends in cell biology 37286396 Trends Cell Biol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37286396
Mesoscale molecular assembly is favored by the active, crowded cytoplasm. Shu T, Mitra G, Alberts J, Viana MP, Levy ED, Hocky GM, Holt LJ bioRxiv : the preprint server for biology 37781612 bioRxiv 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37781612
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. Aber ER, Griffey CJ, Davies T, Li AM, Yang YJ, Croce KR, Goldman JE, Grutzendler J, Canman JC, Yamamoto A Cell reports 36261002 Cell Rep 2022 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/36261002
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis. Rifai OM, Waldron FM, Sleibi D, O'Shaughnessy J, Leighton DJ, Gregory JM Brain pathology (Zurich, Switzerland) 38986433 Brain Pathol 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/38986433
Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis. Rifai OM, Waldron FM, O'Shaughnessy J, Read FL, Gilodi M, Pastore A, Shneider N, Tartaglia GG, Zacco E, Spence H, Gregory JM bioRxiv : the preprint server for biology 38854008 bioRxiv 2024 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/38854008
Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells. Valverde-Mendez D, Sunol AM, Bratton BP, Delarue M, Hofmann JL, Sheehan JP, Gitai Z, Holt LJ, Shaevitz JW, Zia RN bioRxiv : the preprint server for biology 38585850 bioRxiv 2024 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/38585850
A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy. Croce KR, Ng C, Pankiv S, Albarran E, Langfelder P, Ramos de Jesus A, Duncan GM, Wang N, Basile A, McHugh C, Litt NA, Li A, Friedman S, Cortes EP, Zody MC, Yang XW, Ding JB, Vonsattel JPG, Simonsen A, Housman DE, Wexler NS, Yamamoto A Neuron 40945514 Neuron 2025 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/40945514
Mesoscale molecular assembly is favored by the active, crowded cytoplasm. Shu T, Mitra G, Alberts J, Viana MP, Levy ED, Hocky GM, Holt LJ PRX life 40162127 PRX Life 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/40162127
Amyotrophic lateral sclerosis caused by TARDBP mutations: from genetics to TDP-43 proteinopathy. Balendra R, Sreedharan J, Hallegger M, Luisier R, Lashuel HA, Gregory JM, Patani R The Lancet. Neurology 40252666 Lancet Neurol 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40252666
Autophagy Dysfunction and Neurodegeneration: Where Does It Go Wrong? Oettinger D, Yamamoto A Journal of molecular biology 40383464 J Mol Biol 2025 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/40383464
Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy. Vijiaratnam N, Girges C, Wiegand M, Ismail C, Lameirinhas A, Yarnall A, Kirk C, Del-Din S, Rochester L, Kobylecki C, Ambler G, Skene S, Houlden H, Chelban V, Heslegrave A, Phillips W, Whone A, Quinn N, Lambert C, Dore C, Morris HR, Horrocks MH, Lee JE, O'Shaughnessy J, Li Y, Greig NH, Gandhi S, Libri V, Athauda D, Foltynie T Annals of neurology 40727970 Ann Neurol 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/40727970
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration. Murray ME, Smith C, Menon V, Keene CD, Lein E, Hawrylycz M, Aguzzi A, Benedetti B, Brose K, Caetano-Anolles K, Sillero MIC, Crary JF, De Jager PL, Faustin A, Flanagan ME, Gokce O, Grant SGN, Grinberg LT, Gutman DA, Hillman EMC, Huang Z, Irwin DJ, Jones DT, Kapasi A, Karch CM, Kukull WT, Lashley T, Lee EB, Lehner T, Parkkinen L, Pedersen M, Pritchett D, Rutledge MH, Schneider JA, Seeley WW, Shepherd CE, Spires-Jones TL, Steen JA, Sutherland M, Vickovic S, Zhang B, Stewart DJ, Keiser MJ, Vogel JW, Dugger BN, Phatnani H Neuron 40683248 Neuron 2025 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/40683248
Controlling the crowd with a WNK. Holt LJ, Denes LT Cell 36423576 Cell 2022 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/36423576
Machine learning identifies routine blood tests as accurate predictive measures of pollution-dependent poor cognitive function. Johnson H, Longden J, Cameron G, Waiter GD, Waldron FM, Gregory JM, Spence H bioRxiv : the preprint server for biology 39868217 bioRxiv 2025 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/39868217
Increased mesoscale diffusivity in response to acute glucose starvation. Xie Y, Gresham D, Holt LJ microPublication biology 36908311 MicroPubl Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36908311
Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease. Grosso Jasutkar H, Wasserlein EM, Ishola A, Litt N, Staniszewski A, Arancio O, Yamamoto A Autophagy 38949671 Autophagy 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/38949671
SARS-CoV-2 papain-like protease activates nociceptors to drive sneeze and pain. Mali SS, Silva R, Gong Z, Cronce M, Vo U, Vuong C, Moayedi Y, Cox JS, Bautista DM bioRxiv : the preprint server for biology 38260476 bioRxiv 2024 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/38260476
Stem cell transcriptional profiles from mouse subspecies reveal cis-regulatory evolution at translation genes. Simon NM, Kim Y, Gribnau J, Bautista DM, Dutton JR, Brem RB Heredity 39164520 Heredity (Edinb) 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39164520
Basophils add fuel to the flame of eczema itch. Mali SS, Bautista DM Cell 33482094 Cell 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/33482094
Stem cell transcriptional profiles from mouse subspecies reveal cis -regulatory evolution at translation genes. Simon NM, Kim Y, Bautista DM, Dutton JR, Brem RB bioRxiv : the preprint server for biology 37503246 bioRxiv 2024 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/37503246
Avid lysosomal acidification in fibroblasts of the Mediterranean mouse Mus spretus. Sui M, Teh J, Fort K, Shaw D, Sudmant P, Koide T, Good JM, Vazquez JM, Brem RB bioRxiv : the preprint server for biology 39974907 bioRxiv 2025 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/39974907
Intercellular Communication in the Nervous System Goes Viral. Hantak MP, Einstein J, Kearns RB, Shepherd JD Trends in neurosciences 33485691 Trends Neurosci 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33485691
The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation. Park S, Dahn R, Kurt E, Presle A, VanDenHeuvel K, Moravec C, Jambhekar A, Olukoga O, Shepherd J, Echard A, Blower M, Skop AR Developmental cell 37552987 Dev Cell 2023 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/37552987
Expanding the AtLAS of non-coding RNA functions in the brain. Regier MJ, Shepherd JD Cell research 32111970 Cell Res 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32111970
Intercellular Arc Signaling Regulates Vasodilation. de la Peña JB, Barragan-Iglesias P, Lou TF, Kunder N, Loerch S, Shukla T, Basavarajappa L, Song J, James DN, Megat S, Moy JK, Wanghzou A, Ray PR, Hoyt K, Steward O, Price TJ, Shepherd J, Campbell ZT The Journal of neuroscience : the official journal of the Society for Neuroscience 34326146 J Neurosci 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34326146
PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome. Xu J, Erlendsson S, Singh M, Holling GA, Regier M, Ibiricu I, Einstein J, Hantak MP, Day GS, Piquet AL, Smith TL, Clardy SL, Whiteley AM, Feschotte C, Briggs JAG, Shepherd JD Cell 38301645 Cell 2024 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/38301645
Retrotransposons unplugged: Rewiring the nervous system and wreaking havoc. Whiteley AM, Shepherd JD Neuron 41118758 Neuron 2026 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/41118758
dArc1 controls sugar reward valuation in Drosophila melanogaster. Bervoets S, Jacob MS, Devineni AV, Mahoney BD, Sullivan KR, Butts AR, Sung H, Einstein J, Metzstein MM, Dus M, Shepherd JD, Caron SJC Current biology : CB 40782803 Curr Biol 2025 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/40782803
"Arc - A viral vector of memory and synaptic plasticity". Sullivan KR, Ravens A, Walker AC, Shepherd JD Current opinion in neurobiology 39956025 Curr Opin Neurobiol 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/39956025
Arc mediates intercellular tau transmission via extracellular vesicles. Tyagi M, Chadha R, de Hoog E, Sullivan KR, Walker AC, Northrop A, Fabian B, Fuxreiter M, Hyman BT, Shepherd JD bioRxiv : the preprint server for biology 39484489 bioRxiv 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/39484489
PNMA2 forms non-enveloped virus-like capsids that trigger paraneoplastic neurological syndrome. Xu J, Erlendsson S, Singh M, Regier M, Ibiricu I, Day GS, Piquet AL, Clardy SL, Feschotte C, Briggs JAG, Shepherd JD bioRxiv : the preprint server for biology 36798413 bioRxiv 2023 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/36798413
Physiology and diseases of tissue-resident macrophages. Lazarov T, Juarez-Carreño S, Cox N, Geissmann F Nature 37344646 Nature 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37344646
Origins, Biology, and Diseases of Tissue Macrophages. Cox N, Pokrovskii M, Vicario R, Geissmann F Annual review of immunology 33902313 Annu Rev Immunol 2021 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/33902313
Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration. Vicario R, Fragkogianni S, Pokrovskii M, Meyer C, Lopez-Rodrigo E, Hu Y, Ogishi M, Alberdi A, Baako A, Ay O, Plu I, Sazdovitch V, Heritier S, Cohen-Aubart F, Shor N, Miyara M, Nguyen-Khac F, Viale A, Idbaih A, Amoura Z, Rosenblum MK, Zhang H, Karnoub ER, Sashittal P, Jakatdar A, Iacobuzio-Donahue CA, Abdel-Wahab O, Tabar V, Socci ND, Elemento O, Diamond EL, Boisson B, Casanova JL, Seilhean D, Haroche J, Donadieu J, Geissmann F Neuron 40081365 Neuron 2025 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/40081365
A microglia clonal inflammatory disorder in Alzheimer's disease. Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock B, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R, Netherlands Brain Bank, Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F eLife 40085681 Elife 2025 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/40085681
A microglia clonal inflammatory disorder in Alzheimer's Disease. Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock BP, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R, Netherlands Brain Bank, Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F bioRxiv : the preprint server for biology 38328106 bioRxiv 2024 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/38328106
Clonal Hematopoiesis Is Associated With Long-Term Adverse Outcomes Following Cardiac Surgery. Ninni S, Vicario R, Coisne A, Woitrain E, Tazibet A, Stewart CM, Diaz LA Jr, White JR, Koussa M, Dubrulle H, Juthier F, Jungling M, Vincentelli A, Edme JL, Nattel S, de Winther M, Geissmann F, Dombrowicz D, Staels B, Montaigne D Journal of the American Heart Association 39206728 J Am Heart Assoc 2024 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/39206728
Mechanism of neurodegeneration mediated by clonal inflammatory microglia. Vicario R, Fragkogianni S, Pokrovskii M, Mayer C, Lopez-Rodrigo E, Hu Y, Ogishi M, Alberdi A, Baako A, Ay O, Plu I, Sazdovitch V, Heritier S, Cohen-Aubart F, Shor N, Miyara M, Nguyen-Khac F, Viale A, Idbaih A, Amoura Z, Rosenblum MK, Zhang H, Karnoub ER, Sashittal P, Jakatdar A, Iacobuzio-Donahue CA, Abdel-Wahab O, Tabar V, Socci ND, Elemento O, Diamond EL, Boisson B, Casanova JL, Seilhean D, Haroche J, Donadieu J, Geissmann F bioRxiv : the preprint server for biology 39131366 bioRxiv 2024 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/39131366
Hematopoietic Somatic Mosaicism Is Associated With an Increased Risk of Postoperative Atrial Fibrillation. Ninni S, Dombrowicz D, Kuznetsova T, Vicario R, Gao V, Molendi-Coste O, Haas J, Woitrain E, Coisne A, Neele AE, Prange K, Willemsen L, Aghezzaf S, Fragkogianni S, Tazibet A, Pineau L, White JR, Eeckhoute J, Koussa M, Dubrulle H, Juthier F, Soquet J, Vincentelli A, Edme JL, de Winther M, Geissmann F, Staels B, Montaigne D Journal of the American College of Cardiology 36990546 J Am Coll Cardiol 2023 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/36990546
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells. Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Perry JSA, Wong YY, Geissmann F, Cross J, Zhou T, Kam LC, Pasolli HA, Hohl T, Cyster JG, Weiner OD, Huse M Science immunology 38848343 Sci Immunol 2024 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/38848343
Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW Life science alliance 31959624 Life Sci Alliance 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31959624
Tpr regulates the total number of nuclear pore complexes per cell nucleus. McCloskey A, Ibarra A, Hetzer MW Genes & development 30228202 Genes Dev 2018 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/30228202
Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer MW Genes & development 32499403 Genes Dev 2020 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/32499403
Coaching from the sidelines: the nuclear periphery in genome regulation. Buchwalter A, Kaneshiro JM, Hetzer MW Nature reviews. Genetics 30356165 Nat Rev Genet 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30356165
Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Franks TM, McCloskey A, Shokirev MN, Benner C, Rathore A, Hetzer MW Genes & development 29269482 Genes Dev 2017 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/29269482
Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain. Krishna S, Arrojo E Drigo R, Capitanio JS, Ramachandra R, Ellisman M, Hetzer MW Developmental cell 34715012 Dev Cell 2021 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/34715012
Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress. Cho UH, Hetzer MW eLife 37665327 Elife 2023 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/37665327
Nucleoporin-mediated regulation of cell identity genes. Ibarra A, Benner C, Tyagi S, Cool J, Hetzer MW Genes & development 27807035 Genes Dev 2016 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/27807035
Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. Toyama BH, Arrojo E Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene C, Ellisman MH, Hetzer MW The Journal of cell biology 30552100 J Cell Biol 2019 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/30552100
Predicting age from the transcriptome of human dermal fibroblasts. Fleischer JG, Schulte R, Tsai HH, Tyagi S, Ibarra A, Shokhirev MN, Huang L, Hetzer MW, Navlakha S Genome biology 30567591 Genome Biol 2018 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/30567591
Evolution of a transcriptional regulator from a transmembrane nucleoporin. Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW Genes & development 27198230 Genes Dev 2016 May 15 https://www.ncbi.nlm.nih.gov/pubmed/27198230
Age Mosaicism across Multiple Scales in Adult Tissues. Arrojo E Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer MW Cell metabolism 31178361 Cell Metab 2019 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/31178361
Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. Bersini S, Arrojo E Drigo R, Huang L, Shokhirev MN, Hetzer MW Advanced biosystems 32402127 Adv Biosyst 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32402127
Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope. Sharma R, Hetzer MW Life science alliance 37188462 Life Sci Alliance 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37188462
Nucleolar expansion and elevated protein translation in premature aging. Buchwalter A, Hetzer MW Nature communications 28855503 Nat Commun 2017 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/28855503
Nuclear envelope rupture is induced by actin-based nucleus confinement. Hatch EM, Hetzer MW The Journal of cell biology 27697922 J Cell Biol 2016 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/27697922
p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW Nature communications 28004812 Nat Commun 2016 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/28004812
Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging. Cho UH, Hetzer MW Neuron 32553207 Neuron 2020 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/32553207
Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M eLife 31599721 Elife 2019 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/31599721
Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW eLife 32896271 Elife 2020 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/32896271
From cosmos to connectomes: the evolution of data-intensive science. Burns R, Vogelstein JT, Szalay AS Neuron 25233306 Neuron 2014 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/25233306
Knowing a synapse when you see one. Burette A, Collman F, Micheva KD, Smith SJ, Weinberg RJ Frontiers in neuroanatomy 26283929 Front Neuroanat 2015 https://www.ncbi.nlm.nih.gov/pubmed/26283929
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O'Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, Paşca SP Nature methods 26005811 Nat Methods 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26005811
A Computational Synaptic Antibody Characterization Tool for Array Tomography. Simhal AK, Gong B, Trimmer JS, Weinberg RJ, Smith SJ, Sapiro G, Micheva KD Frontiers in neuroanatomy 30065633 Front Neuroanat 2018 https://www.ncbi.nlm.nih.gov/pubmed/30065633
Q&A: Array tomography. Smith SJ BMC biology 30189863 BMC Biol 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/30189863
Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses. Micheva KD, Gong B, Collman F, Weinberg RJ, Smith SJ, Trimmer JS, Murray KD eNeuro 37945352 eNeuro 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37945352
Mapping synapses by conjugate light-electron array tomography. Collman F, Buchanan J, Phend KD, Micheva KD, Weinberg RJ, Smith SJ The Journal of neuroscience : the official journal of the Society for Neuroscience 25855189 J Neurosci 2015 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/25855189
Kernel k-Groups via Hartigan's Method. Franca G, Rizzo ML, Vogelstein JT IEEE transactions on pattern analysis and machine intelligence 32750776 IEEE Trans Pattern Anal Mach Intell 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/32750776
Label-free prediction of three-dimensional fluorescence images from transmitted-light microscopy. Ounkomol C, Seshamani S, Maleckar MM, Collman F, Johnson GR Nature methods 30224672 Nat Methods 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30224672
A community-developed open-source computational ecosystem for big neuro data. Vogelstein JT, Perlman E, Falk B, Baden A, Gray Roncal W, Chandrashekhar V, Collman F, Seshamani S, Patsolic JL, Lillaney K, Kazhdan M, Hider R Jr, Pryor D, Matelsky J, Gion T, Manavalan P, Wester B, Chevillet M, Trautman ET, Khairy K, Bridgeford E, Kleissas DM, Tward DJ, Crow AK, Hsueh B, Wright MA, Miller MI, Smith SJ, Vogelstein RJ, Deisseroth K, Burns R Nature methods 30377345 Nat Methods 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30377345
Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome. Simhal AK, Zuo Y, Perez MM, Madison DV, Sapiro G, Micheva KD Scientific reports 31554841 Sci Rep 2019 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/31554841
A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons. Micheva KD, Wolman D, Mensh BD, Pax E, Buchanan J, Smith SJ, Bock DD eLife 27383052 Elife 2016 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/27383052
Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex. Micheva KD, Chang EF, Nana AL, Seeley WW, Ting JT, Cobbs C, Lein E, Smith SJ, Weinberg RJ, Madison DV eNeuro 30406183 eNeuro 2018 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/30406183
Single-cell transcriptomic evidence for dense intracortical neuropeptide networks. Smith SJ, Sümbül U, Graybuck LT, Collman F, Seshamani S, Gala R, Gliko O, Elabbady L, Miller JA, Bakken TE, Rossier J, Yao Z, Lein E, Zeng H, Tasic B, Hawrylycz M eLife 31710287 Elife 2019 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/31710287
Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Wang GX, Smith SJ, Mourrain P eLife 27770568 Elife 2016 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/27770568
Array tomography of physiologically-characterized CNS synapses. Valenzuela RA, Micheva KD, Kiraly M, Li D, Madison DV Journal of neuroscience methods 27141856 J Neurosci Methods 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/27141856
Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations. Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD Neurology 28130473 Neurology 2017 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/28130473
Antibody validation: a view from the mountains. Taussig MJ, Fonseca C, Trimmer JS New biotechnology 30086383 N Biotechnol 2018 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/30086383
A resource from 3D electron microscopy of hippocampal neuropil for user training and tool development. Harris KM, Spacek J, Bell ME, Parker PH, Lindsey LF, Baden AD, Vogelstein JT, Burns R Scientific data 26347348 Sci Data 2015 https://www.ncbi.nlm.nih.gov/pubmed/26347348
Subcellular organization of UBE3A in human cerebral cortex. Burette AC, Judson MC, Li AN, Chang EF, Seeley WW, Philpot BD, Weinberg RJ Molecular autism 30364390 Mol Autism 2018 https://www.ncbi.nlm.nih.gov/pubmed/30364390
Data-driven synapse classification reveals a logic of glutamate receptor diversity. Micheva KD, Simhal AK, Schardt J, Smith SJ, Weinberg RJ, Owen SF bioRxiv : the preprint server for biology 39713368 bioRxiv 2025 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/39713368
Developing a Toolbox of Antibodies Validated for Array Tomography-Based Imaging of Brain Synapses. Micheva KD, Gong B, Collman F, Weinberg RJ, Smith SJ, Trimmer JS, Murray KD bioRxiv : the preprint server for biology 37425759 bioRxiv 2023 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/37425759
In vitro and in cellula site-directed RNA editing using the λNDD-BoxB system. Ojha N, Diaz Quiroz JF, Rosenthal JJC Methods in enzymology 34517953 Methods Enzymol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34517953
Trade-off between Transcriptome Plasticity and Genome Evolution in Cephalopods. Liscovitch-Brauer N, Alon S, Porath HT, Elstein B, Unger R, Ziv T, Admon A, Levanon EY, Rosenthal JJC, Eisenberg E Cell 28388405 Cell 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28388405
The emerging role of RNA editing in plasticity. Rosenthal JJ The Journal of experimental biology 26085659 J Exp Biol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/26085659
In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing. Sinnamon JR, Kim SY, Fisk JR, Song Z, Nakai H, Jeng S, McWeeney SK, Mandel G Cell reports 32668243 Cell Rep 2020 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/32668243
Current strategies for Site-Directed RNA Editing using ADARs. Montiel-Gonzalez MF, Diaz Quiroz JF, Rosenthal JJC Methods (San Diego, Calif.) 30502398 Methods 2019 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/30502398
An efficient system for selectively altering genetic information within mRNAs. Montiel-González MF, Vallecillo-Viejo IC, Rosenthal JJ Nucleic acids research 27557710 Nucleic Acids Res 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27557710
Site-directed RNA repair of endogenous Mecp2 RNA in neurons. Sinnamon JR, Kim SY, Corson GM, Song Z, Nakai H, Adelman JP, Mandel G Proceedings of the National Academy of Sciences of the United States of America 29078406 Proc Natl Acad Sci U S A 2017 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/29078406
Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing. Ferrick-Kiddie EA, Rosenthal JJ, Ayers GD, Emeson RB Scientific reports 28216637 Sci Rep 2017 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/28216637
Feedback from peripheral musculature to central pattern generator in the neurogenic heart of the crab Callinectes sapidus: role of mechanosensitive dendrites. García-Crescioni K, Fort TJ, Stern E, Brezina V, Miller MW Journal of neurophysiology 19828726 J Neurophysiol 2010 Jan https://www.ncbi.nlm.nih.gov/pubmed/19828726
Comparative neurobiology of feeding in the opisthobranch sea slug, Aplysia, and the pulmonate snail, Helisoma: evolutionary considerations. Wentzell MM, Martínez-Rubio C, Miller MW, Murphy AD Brain, behavior and evolution 20029185 Brain Behav Evol 2009 https://www.ncbi.nlm.nih.gov/pubmed/20029185
Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme. Vallecillo-Viejo IC, Liscovitch-Brauer N, Montiel-Gonzalez MF, Eisenberg E, Rosenthal JJC RNA biology 29099293 RNA Biol 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29099293
Using proprioception to get a better grasp on embodiment. Marasco PD The Journal of physiology 29194626 J Physiol 2018 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/29194626
Advances in the measurement of prosthetic socket interface mechanics: a review of technology, techniques, and a 20-year update. Young PR, Hebert JS, Marasco PD, Carey JP, Schofield JS Expert review of medical devices 37537898 Expert Rev Med Devices 2023 Jul-Dec https://www.ncbi.nlm.nih.gov/pubmed/37537898
Characterizing the effects of amplitude, frequency and limb position on vibration induced movement illusions: Implications in sensory-motor rehabilitation. Schofield JS, Dawson MR, Carey JP, Hebert JS Technology and health care : official journal of the European Society for Engineering and Medicine 25425585 Technol Health Care 2015 https://www.ncbi.nlm.nih.gov/pubmed/25425585
Characterization of the Sense of Agency over the Actions of Neural-machine Interface-operated Prostheses. Schofield JS, Shell CE, Thumser ZC, Beckler DT, Nataraj R, Marasco PD Journal of visualized experiments : JoVE 30663709 J Vis Exp 2019 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/30663709
The neural response properties and cortical organization of a rapidly adapting muscle sensory group response that overlaps with the frequencies that elicit the kinesthetic illusion. Marasco PD, Bourbeau DJ, Shell CE, Granja-Vazquez R, Ina JG PloS one 29182648 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/29182648
Characterization of interfacial socket pressure in transhumeral prostheses: A case series. Schofield JS, Schoepp KR, Williams HE, Carey JP, Marasco PD, Hebert JS PloS one 28575012 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/28575012
Illusory movement perception improves motor control for prosthetic hands. Marasco PD, Hebert JS, Sensinger JW, Shell CE, Schofield JS, Thumser ZC, Nataraj R, Beckler DT, Dawson MR, Blustein DH, Gill S, Mensh BD, Granja-Vazquez R, Newcomb MD, Carey JP, Orzell BM Science translational medicine 29540617 Sci Transl Med 2018 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/29540617
The effect of biomechanical variables on force sensitive resistor error: Implications for calibration and improved accuracy. Schofield JS, Evans KR, Hebert JS, Marasco PD, Carey JP Journal of biomechanics 26903413 J Biomech 2016 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/26903413
Crossmodal congruency effect scores decrease with repeat test exposure. Blustein D, Gill S, Wilson A, Sensinger J PeerJ 31179180 PeerJ 2019 https://www.ncbi.nlm.nih.gov/pubmed/31179180
Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics. McCall JG, Kim TI, Shin G, Huang X, Jung YH, Al-Hasani R, Omenetto FG, Bruchas MR, Rogers JA Nature protocols 24202555 Nat Protoc 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24202555
Spatiotemporal control of opioid signaling and behavior. Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR Neuron 25937173 Neuron 2015 May 20 https://www.ncbi.nlm.nih.gov/pubmed/25937173
A bright future? Optogenetics in the periphery for pain research and therapy. Mickle AD, Gereau RW 4th Pain 30113949 Pain 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30113949
A wireless closed-loop system for optogenetic peripheral neuromodulation. Mickle AD, Won SM, Noh KN, Yoon J, Meacham KW, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Payne MA, Zhang J, Jang H, Li Y, Lai HH, Huang Y, Park SI, Gereau RW 4th, Rogers JA Nature 30602791 Nature 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30602791
Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain. Samineni VK, Mickle AD, Yoon J, Grajales-Reyes JG, Pullen MY, Crawford KE, Noh KN, Gereau GB, Vogt SK, Lai HH, Rogers JA, Gereau RW 4th Scientific reports 29158567 Sci Rep 2017 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/29158567
Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics. Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW 4th, Bruchas MR, Rogers JA Proceedings of the National Academy of Sciences of the United States of America 27911798 Proc Natl Acad Sci U S A 2016 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/27911798
Optodynamic simulation of β-adrenergic receptor signalling. Siuda ER, McCall JG, Al-Hasani R, Shin G, Il Park S, Schmidt MJ, Anderson SL, Planer WJ, Rogers JA, Bruchas MR Nature communications 26412387 Nat Commun 2015 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/26412387
Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray. Samineni VK, Grajales-Reyes JG, Copits BA, O'Brien DE, Trigg SL, Gomez AM, Bruchas MR, Gereau RW 4th eNeuro 28374016 eNeuro 2017 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/28374016
Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics. Park SI, Shin G, Banks A, McCall JG, Siuda ER, Schmidt MJ, Chung HU, Noh KN, Mun JG, Rhodes J, Bruchas MR, Rogers JA Journal of neural engineering 26193450 J Neural Eng 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26193450
Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruchas MR, Gereau RW 4th, Rogers JA Nature biotechnology 26551059 Nat Biotechnol 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26551059
Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. Zhang Y, Mickle AD, Gutruf P, McIlvried LA, Guo H, Wu Y, Golden JP, Xue Y, Grajales-Reyes JG, Wang X, Krishnan S, Xie Y, Peng D, Su CJ, Zhang F, Reeder JT, Vogt SK, Huang Y, Rogers JA, Gereau RW 4th Science advances 31281895 Sci Adv 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31281895
Intraoperative monitoring of neuromuscular function with soft, skin-mounted wireless devices. Liu Y, Tian L, Raj MS, Cotton M, Ma Y, Ma S, McGrane B, Pendharkar AV, Dahaleh N, Olson L, Luan H, Block O, Suleski B, Zhou Y, Jayaraman C, Koski T, Aranyosi AJ, Wright JA, Jayaraman A, Huang Y, Ghaffari R, Kliot M, Rogers JA NPJ digital medicine 30882044 NPJ Digit Med 2018 https://www.ncbi.nlm.nih.gov/pubmed/30882044
Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Kim TI, McCall JG, Jung YH, Huang X, Siuda ER, Li Y, Song J, Song YM, Pao HA, Kim RH, Lu C, Lee SD, Song IS, Shin G, Al-Hasani R, Kim S, Tan MP, Huang Y, Omenetto FG, Rogers JA, Bruchas MR Science (New York, N.Y.) 23580530 Science 2013 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/23580530
Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits. Copits BA, Pullen MY, Gereau RW 4th Pain 27340912 Pain 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27340912
Optogenetic Induction of Colonic Motility in Mice. Hibberd TJ, Feng J, Luo J, Yang P, Samineni VK, Gereau RW 4th, Kelley N, Hu H, Spencer NJ Gastroenterology 29782847 Gastroenterology 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29782847
Differential Regulation of Bladder Pain and Voiding Function by Sensory Afferent Populations Revealed by Selective Optogenetic Activation. DeBerry JJ, Samineni VK, Copits BA, Sullivan CJ, Vogt SK, Albers KM, Davis BM, Gereau RW IV Frontiers in integrative neuroscience 29483864 Front Integr Neurosci 2018 https://www.ncbi.nlm.nih.gov/pubmed/29483864
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics. Noh KN, Park SI, Qazi R, Zou Z, Mickle AD, Grajales-Reyes JG, Jang KI, Gereau RW 4th, Xiao J, Rogers JA, Jeong JW Small (Weinheim an der Bergstrasse, Germany) 29215787 Small 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29215787
Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics. Samineni VK, Yoon J, Crawford KE, Jeong YR, McKenzie KC, Shin G, Xie Z, Sundaram SS, Li Y, Yang MY, Kim J, Wu D, Xue Y, Feng X, Huang Y, Mickle AD, Banks A, Ha JS, Golden JP, Rogers JA, Gereau RW 4th Pain 28700536 Pain 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28700536
A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Brenner DS, Golden JP, Vogt SK, Dhaka A, Story GM, Gereau RW IV Pain 25109670 Pain 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25109670
Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Jeong JW, McCall JG, Shin G, Zhang Y, Al-Hasani R, Kim M, Li S, Sim JY, Jang KI, Shi Y, Hong DY, Liu Y, Schmitz GP, Xia L, He Z, Gamble P, Ray WZ, Huang Y, Bruchas MR, Rogers JA Cell 26189679 Cell 2015 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/26189679
Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR Neuron 26335648 Neuron 2015 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/26335648
Erratum: Thermal analysis of injectable, cellular-scale optoelectronics with pulsed power. Li Y, Shi X, Song J, Lü C, Kim TI, McCall JG, Bruchas MR, Rogers JA, Huang Y Proceedings. Mathematical, physical, and engineering sciences 24062627 Proc Math Phys Eng Sci 2013 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/24062627
A technique to measure cold adaptation in freely behaving mice. Brenner DS, Vogt SK, Gereau RW 4th Journal of neuroscience methods 25128723 J Neurosci Methods 2014 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/25128723
Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RW 4th, Ha JS, Bruchas MR, Rogers JA Neuron 28132830 Neuron 2017 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/28132830
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Vanharanta S, Marney CB, Shu W, Valiente M, Zou Y, Mele A, Darnell RB, Massagué J eLife 24898756 Elife 2014 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/24898756
RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares. Orange DE, Yao V, Sawicka K, Fak J, Frank MO, Parveen S, Blachere NE, Hale C, Zhang F, Raychaudhuri S, Troyanskaya OG, Darnell RB The New England journal of medicine 32668112 N Engl J Med 2020 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/32668112
PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage. Hwang HW, Park CY, Goodarzi H, Fak JJ, Mele A, Moore MJ, Saito Y, Darnell RB Cell reports 27050522 Cell Rep 2016 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/27050522
Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. Scheckel C, Drapeau E, Frias MA, Park CY, Fak J, Zucker-Scharff I, Kou Y, Haroutunian V, Ma'ayan A, Buxbaum JD, Darnell RB eLife 26894958 Elife 2016 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/26894958
ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity. Moore MJ, Blachere NE, Fak JJ, Park CY, Sawicka K, Parveen S, Zucker-Scharff I, Moltedo B, Rudensky AY, Darnell RB eLife 29848443 Elife 2018 May 31 https://www.ncbi.nlm.nih.gov/pubmed/29848443
FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons. Hale CR, Sawicka K, Mora K, Fak JJ, Kang JJ, Cutrim P, Cialowicz K, Carroll TS, Darnell RB eLife 34939924 Elife 2021 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/34939924
NOVA2-mediated RNA regulation is required for axonal pathfinding during development. Saito Y, Miranda-Rottmann S, Ruggiu M, Park CY, Fak JJ, Zhong R, Duncan JS, Fabella BA, Junge HJ, Chen Z, Araya R, Fritzsch B, Hudspeth AJ, Darnell RB eLife 27223325 Elife 2016 May 25 https://www.ncbi.nlm.nih.gov/pubmed/27223325
Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Korb E, Herre M, Zucker-Scharff I, Gresack J, Allis CD, Darnell RB Cell 28823556 Cell 2017 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/28823556
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding. Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB Nature neuroscience 38589584 Nat Neurosci 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38589584
Prediction of clustered RNA-binding protein motif sites in the mammalian genome. Zhang C, Lee KY, Swanson MS, Darnell RB Nucleic acids research 23685613 Nucleic Acids Res 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23685613
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice. Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB, Swanson MS Human molecular genetics 23660517 Hum Mol Genet 2013 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/23660517
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, Darnell RB eLife 23359859 Elife 2013 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/23359859
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Weyn-Vanhentenryck SM, Mele A, Yan Q, Sun S, Farny N, Zhang Z, Xue C, Herre M, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C Cell reports 24613350 Cell Rep 2014 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/24613350
T cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation. Blachère NE, Orange DE, Santomasso BD, Doerner J, Foo PK, Herre M, Fak J, Monette S, Gantman EC, Frank MO, Darnell RB European journal of immunology 25103845 Eur J Immunol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25103845
BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice. Korb E, Herre M, Zucker-Scharff I, Darnell RB, Allis CD Nature neuroscience 26301327 Nat Neurosci 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26301327
Microexons--tiny but mighty. Scheckel C, Darnell RB The EMBO journal 25535247 EMBO J 2015 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/25535247
cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation. Hwang HW, Saito Y, Park CY, Blachère NE, Tajima Y, Fak JJ, Zucker-Scharff I, Darnell RB Neuron 28910620 Neuron 2017 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/28910620
Comprehensive Identification of mRNA Polyadenylation Sites by PAPERCLIP. Hwang HW, Darnell RB Methods in molecular biology (Clifton, N.J.) 28766291 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28766291
NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells. Saito Y, Yang Y, Saito M, Park CY, Funato K, Tabar V, Darnell RB Proceedings of the National Academy of Sciences of the United States of America 38416679 Proc Natl Acad Sci U S A 2024 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/38416679
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RB Neuron 22998874 Neuron 2012 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/22998874
RNA protein interaction in neurons. Darnell RB Annual review of neuroscience 23701460 Annu Rev Neurosci 2013 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/23701460
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB Genes & development 26404942 Genes Dev 2015 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/26404942
A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration. Scheel TK, Luna JM, Liniger M, Nishiuchi E, Rozen-Gagnon K, Shlomai A, Auray G, Gerber M, Fak J, Keller I, Bruggmann R, Darnell RB, Ruggli N, Rice CM Cell host & microbe 26962949 Cell Host Microbe 2016 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/26962949
miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity. Moore MJ, Scheel TK, Luna JM, Park CY, Fak JJ, Nishiuchi E, Rice CM, Darnell RB Nature communications 26602609 Nat Commun 2015 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/26602609
FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory. Sawicka K, Hale CR, Park CY, Fak JJ, Gresack JE, Van Driesche SJ, Kang JJ, Darnell JC, Darnell RB eLife 31860442 Elife 2019 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/31860442
Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk. Zhou J, Park CY, Theesfeld CL, Wong AK, Yuan Y, Scheckel C, Fak JJ, Funk J, Yao K, Tajima Y, Packer A, Darnell RB, Troyanskaya OG Nature genetics 31133750 Nat Genet 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31133750
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K Molecular cell 28735896 Mol Cell 2017 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/28735896
Hepatitis C virus RNA functionally sequesters miR-122. Luna JM, Scheel TK, Danino T, Shaw KS, Mele A, Fak JJ, Nishiuchi E, Takacs CN, Catanese MT, de Jong YP, Jacobson IM, Rice CM, Darnell RB Cell 25768906 Cell 2015 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/25768906
The Genetic Control of Stoichiometry Underlying Autism. Darnell RB Annual review of neuroscience 32640929 Annu Rev Neurosci 2020 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/32640929
PRIME Cells Predicting Rheumatoid Arthritis Flares. Reply. Orange DE, Darnell RB The New England journal of medicine 33053295 N Engl J Med 2020 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/33053295
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY Molecular cell 23142080 Mol Cell 2012 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/23142080
m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB Genes & development 28637692 Genes Dev 2017 May 15 https://www.ncbi.nlm.nih.gov/pubmed/28637692
NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z eLife 27223328 Elife 2016 May 25 https://www.ncbi.nlm.nih.gov/pubmed/27223328
Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen. Linderman JA, Kobayashi M, Rayannavar V, Fak JJ, Darnell RB, Chao MV, Wilson AC, Mohr I Cell reports 28147283 Cell Rep 2017 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/28147283
Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types. Jereb S, Hwang HW, Van Otterloo E, Govek EE, Fak JJ, Yuan Y, Hatten ME, Darnell RB eLife 29578408 Elife 2018 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/29578408
Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis. Moore MJ, Zhang C, Gantman EC, Mele A, Darnell JC, Darnell RB Nature protocols 24407355 Nat Protoc 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24407355
AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke. Kobayashi M, Benakis C, Anderson C, Moore MJ, Poon C, Uekawa K, Dyke JP, Fak JJ, Mele A, Park CY, Zhou P, Anrather J, Iadecola C, Darnell RB Cell reports 31340158 Cell Rep 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31340158
Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function. Saito Y, Yuan Y, Zucker-Scharff I, Fak JJ, Jereb S, Tajima Y, Licatalosi DD, Darnell RB Neuron 30638744 Neuron 2019 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/30638744
NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons. Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y, Darnell RB Cell reports 36716149 Cell Rep 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/36716149
Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease. Irmady K, Hale CR, Qadri R, Fak J, Simelane S, Carroll T, Przedborski S, Darnell RB Nature communications 37407548 Nat Commun 2023 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/37407548
A survey of human brain transcriptome diversity at the single cell level. Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden Gephart MG, Barres BA, Quake SR Proceedings of the National Academy of Sciences of the United States of America 26060301 Proc Natl Acad Sci U S A 2015 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/26060301
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Sloan SA, Darmanis S, Huber N, Khan TA, Birey F, Caneda C, Reimer R, Quake SR, Barres BA, Paşca SP Neuron 28817799 Neuron 2017 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/28817799
Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination. Dong X, Chen K, Cuevas-Diaz Duran R, You Y, Sloan SA, Zhang Y, Zong S, Cao Q, Barres BA, Wu JQ PLoS genetics 26683846 PLoS Genet 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26683846
Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma. Darmanis S, Sloan SA, Croote D, Mignardi M, Chernikova S, Samghababi P, Zhang Y, Neff N, Kowarsky M, Caneda C, Li G, Chang SD, Connolly ID, Li Y, Barres BA, Gephart MH, Quake SR Cell reports 29091775 Cell Rep 2017 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/29091775
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse. Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MS, Li G, Duncan JA 3rd, Cheshier SH, Shuer LM, Chang EF, Grant GA, Gephart MG, Barres BA Neuron 26687838 Neuron 2016 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/26687838
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ The Journal of neuroscience : the official journal of the Society for Neuroscience 25186741 J Neurosci 2014 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/25186741
Neuronal cell types and connectivity: lessons from the retina. Seung HS, Sümbül U Neuron 25233310 Neuron 2014 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/25233310
Clarifying Tissue Clearing. Richardson DS, Lichtman JW Cell 26186186 Cell 2015 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/26186186
Design and Evaluation of Interactive Proofreading Tools for Connectomics. Haehn D, Knowles-Barley S, Roberts M, Beyer J, Kasthuri N, Lichtman JW, Pfister H IEEE transactions on visualization and computer graphics 26356960 IEEE Trans Vis Comput Graph 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/26356960
Digital tissue and what it may reveal about the brain. Morgan JL, Lichtman JW BMC biology 29084528 BMC Biol 2017 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/29084528
Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition. Wilson AM, Schalek R, Suissa-Peleg A, Jones TR, Knowles-Barley S, Pfister H, Lichtman JW Cell reports 31775050 Cell Rep 2019 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/31775050
Imaging ATUM ultrathin section libraries with WaferMapper: a multi-scale approach to EM reconstruction of neural circuits. Hayworth KJ, Morgan JL, Schalek R, Berger DR, Hildebrand DG, Lichtman JW Frontiers in neural circuits 25018701 Front Neural Circuits 2014 https://www.ncbi.nlm.nih.gov/pubmed/25018701
Saturated Reconstruction of a Volume of Neocortex. Kasthuri N, Hayworth KJ, Berger DR, Schalek RL, Conchello JA, Knowles-Barley S, Lee D, Vázquez-Reina A, Kaynig V, Jones TR, Roberts M, Morgan JL, Tapia JC, Seung HS, Roncal WG, Vogelstein JT, Burns R, Sussman DL, Priebe CE, Pfister H, Lichtman JW Cell 26232230 Cell 2015 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/26232230
Reconstruction of genetically identified neurons imaged by serial-section electron microscopy. Joesch M, Mankus D, Yamagata M, Shahbazi A, Schalek R, Suissa-Peleg A, Meister M, Lichtman JW, Scheirer WJ, Sanes JR eLife 27383271 Elife 2016 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/27383271
Multispectral tracing in densely labeled mouse brain with nTracer. Roossien DH, Sadis BV, Yan Y, Webb JM, Min LY, Dizaji AS, Bogart LJ, Mazuski C, Huth RS, Stecher JS, Akula S, Shen F, Li Y, Xiao T, Vandenbrink M, Lichtman JW, Hensch TK, Herzog ED, Cai D Bioinformatics (Oxford, England) 30715234 Bioinformatics 2019 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/30715234
Why not connectomics? Morgan JL, Lichtman JW Nature methods 23722208 Nat Methods 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23722208
Methods for Mapping Neuronal Activity to Synaptic Connectivity: Lessons From Larval Zebrafish. Wanner AA, Vishwanathan A Frontiers in neural circuits 30410437 Front Neural Circuits 2018 https://www.ncbi.nlm.nih.gov/pubmed/30410437
The Fuzzy Logic of Network Connectivity in Mouse Visual Thalamus. Morgan JL, Berger DR, Wetzel AW, Lichtman JW Cell 27015312 Cell 2016 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/27015312
The big data challenges of connectomics. Lichtman JW, Pfister H, Shavit N Nature neuroscience 25349911 Nat Neurosci 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25349911
Neural Circuit Inference from Function to Structure. Real E, Asari H, Gollisch T, Meister M Current biology : CB 28065610 Curr Biol 2017 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/28065610
Space-time wiring specificity supports direction selectivity in the retina. Kim JS, Greene MJ, Zlateski A, Lee K, Richardson M, Turaga SC, Purcaro M, Balkam M, Robinson A, Behabadi BF, Campos M, Denk W, Seung HS, EyeWirers Nature 24805243 Nature 2014 May 15 https://www.ncbi.nlm.nih.gov/pubmed/24805243
An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus. Morgan JL, Lichtman JW Neuron 32142646 Neuron 2020 May 6 https://www.ncbi.nlm.nih.gov/pubmed/32142646
Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator. Vishwanathan A, Daie K, Ramirez AD, Lichtman JW, Aksay ERF, Seung HS Current biology : CB 28712570 Curr Biol 2017 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/28712570
Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology. Bae JA, Mu S, Kim JS, Turner NL, Tartavull I, Kemnitz N, Jordan CS, Norton AD, Silversmith WM, Prentki R, Sorek M, David C, Jones DL, Bland D, Sterling ALR, Park J, Briggman KL, Seung HS, Eyewirers Cell 29775596 Cell 2018 May 17 https://www.ncbi.nlm.nih.gov/pubmed/29775596
Large-scale automatic reconstruction of neuronal processes from electron microscopy images. Kaynig V, Vazquez-Reina A, Knowles-Barley S, Roberts M, Jones TR, Kasthuri N, Miller E, Lichtman J, Pfister H Medical image analysis 25791436 Med Image Anal 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25791436
NeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity. Al-Awami AK, Beyer J, Strobelt H, Kasthuri N, Lichtman JW, Pfister H, Hadwiger M IEEE transactions on visualization and computer graphics 26356951 IEEE Trans Vis Comput Graph 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/26356951
Analogous Convergence of Sustained and Transient Inputs in Parallel On and Off Pathways for Retinal Motion Computation. Greene MJ, Kim JS, Seung HS, EyeWirers Cell reports 26904938 Cell Rep 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26904938
Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers. Ricarte-Filho JC, Li S, Garcia-Rendueles ME, Montero-Conde C, Voza F, Knauf JA, Heguy A, Viale A, Bogdanova T, Thomas GA, Mason CE, Fagin JA The Journal of clinical investigation 24135138 J Clin Invest 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24135138
Characterizing multi-omic data in systems biology. Mason CE, Porter SG, Smith TM Advances in experimental medicine and biology 24292960 Adv Exp Med Biol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24292960
Dynamic evolution of clonal epialleles revealed by methclone. Li S, Garrett-Bakelman F, Perl AE, Luger SM, Zhang C, To BL, Lewis ID, Brown AL, D'Andrea RJ, Ross ME, Levine R, Carroll M, Melnick A, Mason CE Genome biology 25260792 Genome Biol 2014 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/25260792
Rare LRP6 variants identified in spina bifida patients. Lei Y, Fathe K, McCartney D, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH Human mutation 25546815 Hum Mutat 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25546815
An optimized algorithm for detecting and annotating regional differential methylation. Li S, Garrett-Bakelman FE, Akalin A, Zumbo P, Levine R, To BL, Lewis ID, Brown AL, D'Andrea RJ, Melnick A, Mason CE BMC bioinformatics 23735126 BMC Bioinformatics 2013 https://www.ncbi.nlm.nih.gov/pubmed/23735126
The continuing challenge of understanding, preventing, and treating neural tube defects. Wallingford JB, Niswander LA, Shaw GM, Finnell RH Science (New York, N.Y.) 23449594 Science 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23449594
A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study. Lupo PJ, Chapa C, Nousome D, Duhon C, Canfield MA, Shaw GM, Finnell RH, Zhu H, National Birth Defects Prevention Study Molecular genetics and metabolism 23059057 Mol Genet Metab 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/23059057
The birth of the Epitranscriptome: deciphering the function of RNA modifications. Saletore Y, Meyer K, Korlach J, Vilfan ID, Jaffrey S, Mason CE Genome biology 23113984 Genome Biol 2012 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/23113984
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, Milne TA, Huang Y, Biswas D, Hess JL, Allis CD, Roeder RG, Valk PJ, Löwenberg B, Delwel R, Fernandez HF, Paietta E, Tallman MS, Schroth GP, Mason CE, Melnick A, Figueroa ME PLoS genetics 22737091 PLoS Genet 2012 https://www.ncbi.nlm.nih.gov/pubmed/22737091
Rfx2 is required for spermatogenesis in the mouse. Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH Genesis (New York, N.Y. : 2000) 26248850 Genesis 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26248850
Genetic and epigenetic heterogeneity in acute myeloid leukemia. Li S, Mason CE, Melnick A Current opinion in genetics & development 27162099 Curr Opin Genet Dev 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/27162099
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers. Bezdan D, Grigorev K, Meydan C, Pelissier Vatter FA, Cioffi M, Rao V, MacKay M, Nakahira K, Burnham P, Afshinnekoo E, Westover C, Butler D, Mozsary C, Donahoe T, Foox J, Mishra T, Lucotti S, Rana BK, Melnick AM, Zhang H, Matei I, Kelsen D, Yu K, Lyden DC, Taylor L, Bailey SM, Snyder MP, Garrett-Bakelman FE, Ossowski S, De Vlaminck I, Mason CE iScience 33376973 iScience 2020 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/33376973
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood. Ng DL, Granados AC, Santos YA, Servellita V, Goldgof GM, Meydan C, Sotomayor-Gonzalez A, Levine AG, Balcerek J, Han LM, Akagi N, Truong K, Neumann NM, Nguyen DN, Bapat SP, Cheng J, Martin CS, Federman S, Foox J, Gopez A, Li T, Chan R, Chu CS, Wabl CA, Gliwa AS, Reyes K, Pan CY, Guevara H, Wadford D, Miller S, Mason CE, Chiu CY Science advances 33536218 Sci Adv 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33536218
Autism-Like Behavior and Epigenetic Changes Associated with Autism as Consequences of In Utero Exposure to Environmental Pollutants in a Mouse Model. Hill DS, Cabrera R, Wallis Schultz D, Zhu H, Lu W, Finnell RH, Wlodarczyk BJ Behavioural neurology 26586927 Behav Neurol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26586927
Genomic approaches to the assessment of human spina bifida risk. Ross ME, Mason CE, Finnell RH Birth defects research 27883265 Birth Defects Res 2017 Jan 30 https://www.ncbi.nlm.nih.gov/pubmed/27883265
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients. Afshinnekoo E, Mason CE Annals of translational medicine 27942527 Ann Transl Med 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27942527
The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report. MetaSUB International Consortium Microbiome 27255532 Microbiome 2016 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/27255532
Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain. Nandi S, Chandramohan D, Fioriti L, Melnick AM, Hébert JM, Mason CE, Rajasethupathy P, Kandel ER Proceedings of the National Academy of Sciences of the United States of America 27791114 Proc Natl Acad Sci U S A 2016 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/27791114
Nanopore sequencing in microgravity. McIntyre ABR, Rizzardi L, Yu AM, Alexander N, Rosen GL, Botkin DJ, Stahl SE, John KK, Castro-Wallace SL, McGrath K, Burton AS, Feinberg AP, Mason CE NPJ microgravity 28725742 NPJ Microgravity 2016 https://www.ncbi.nlm.nih.gov/pubmed/28725742
Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. Toriyama M, Toriyama M, Wallingford JB, Finnell RH FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28432198 FASEB J 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28432198
Epigenetic Modifications in Acute Myeloid Leukemia: Prognosis, Treatment, and Heterogeneity. Goldman SL, Hassan C, Khunte M, Soldatenko A, Jong Y, Afshinnekoo E, Mason CE Frontiers in genetics 30881380 Front Genet 2019 https://www.ncbi.nlm.nih.gov/pubmed/30881380
Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes. Tabler JM, Barrell WB, Szabo-Rogers HL, Healy C, Yeung Y, Perdiguero EG, Schulz C, Yannakoudakis BZ, Mesbahi A, Wlodarczyk B, Geissmann F, Finnell RH, Wallingford JB, Liu KJ Developmental cell 23806618 Dev Cell 2013 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/23806618
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Linder B, Grozhik AV, Olarerin-George AO, Meydan C, Mason CE, Jaffrey SR Nature methods 26121403 Nat Methods 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26121403
High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans. Lipovich L, Hou ZC, Jia H, Sinkler C, McGowen M, Sterner KN, Weckle A, Sugalski AB, Pipes L, Gatti DL, Mason CE, Sherwood CC, Hof PR, Kuzawa CW, Grossman LI, Goodman M, Wildman DE The Journal of comparative neurology 26132897 J Comp Neurol 2016 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/26132897
The impact of read length on quantification of differentially expressed genes and splice junction detection. Chhangawala S, Rudy G, Mason CE, Rosenfeld JA Genome biology 26100517 Genome Biol 2015 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/26100517
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. SEQC/MAQC-III Consortium Nature biotechnology 25150838 Nat Biotechnol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25150838
Enabling large-scale next-generation sequence assembly with Blacklight. Couger MB, Pipes L, Squina F, Prade R, Siepel A, Palermo R, Katze MG, Mason CE, Blood PD Concurrency and computation : practice & experience 25294974 Concurr Comput 2014 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/25294974
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Shih AH, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L, Antony-Debre I, Viale A, Socci N, Sun Y, Robertson A, Cavatore M, de Stanchina E, Hricik T, Rapaport F, Woods B, Wei C, Hatlen M, Baljevic M, Nimer SD, Tallman M, Paietta E, Cimmino L, Aifantis I, Steidl U, Mason C, Melnick A, Levine RL Cancer cell 25873173 Cancer Cell 2015 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/25873173
Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study. Li S, Tighe SW, Nicolet CM, Grove D, Levy S, Farmerie W, Viale A, Wright C, Schweitzer PA, Gao Y, Kim D, Boland J, Hicks B, Kim R, Chhangawala S, Jafari N, Raghavachari N, Gandara J, Garcia-Reyero N, Hendrickson C, Roberson D, Rosenfeld J, Smith T, Underwood JG, Wang M, Zumbo P, Baldwin DA, Grills GS, Mason CE Nature biotechnology 25150835 Nat Biotechnol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25150835
Tissue-specific transcriptome sequencing analysis expands the non-human primate reference transcriptome resource (NHPRTR). Peng X, Thierry-Mieg J, Thierry-Mieg D, Nishida A, Pipes L, Bozinoski M, Thomas MJ, Kelly S, Weiss JM, Raveendran M, Muzny D, Gibbs RA, Rogers J, Schroth GP, Katze MG, Mason CE Nucleic acids research 25392405 Nucleic Acids Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25392405
Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution. Garrett-Bakelman FE, Sheridan CK, Kacmarczyk TJ, Ishii J, Betel D, Alonso A, Mason CE, Figueroa ME, Melnick AM Journal of visualized experiments : JoVE 25742437 J Vis Exp 2015 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/25742437
Clinical Genomics: Challenges and Opportunities. Vijay P, McIntyre AB, Mason CE, Greenfield JP, Li S Critical reviews in eukaryotic gene expression 27480773 Crit Rev Eukaryot Gene Expr 2016 https://www.ncbi.nlm.nih.gov/pubmed/27480773
Haplotype diversity and sequence heterogeneity of human telomeres. Grigorev K, Foox J, Bezdan D, Butler D, Luxton JJ, Reed J, McKenna MJ, Taylor L, George KA, Meydan C, Bailey SM, Mason CE Genome research 34162698 Genome Res 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34162698
Translating current biomedical therapies for long duration, deep space missions. Iosim S, MacKay M, Westover C, Mason CE Precision clinical medicine 31886035 Precis Clin Med 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31886035
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials. McIntyre ABR, Alexander N, Grigorev K, Bezdan D, Sichtig H, Chiu CY, Mason CE Nature communications 30718479 Nat Commun 2019 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/30718479
Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius. Rosenfeld JA, Reeves D, Brugler MR, Narechania A, Simon S, Durrett R, Foox J, Shianna K, Schatz MC, Gandara J, Afshinnekoo E, Lam ET, Hastie AR, Chan S, Cao H, Saghbini M, Kentsis A, Planet PJ, Kholodovych V, Tessler M, Baker R, DeSalle R, Sorkin LN, Kolokotronis SO, Siddall ME, Amato G, Mason CE Nature communications 26836631 Nat Commun 2016 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/26836631
The Impact of Heterogeneity on Single-Cell Sequencing. Goldman SL, MacKay M, Afshinnekoo E, Melnick AM, Wu S, Mason CE Frontiers in genetics 30881372 Front Genet 2019 https://www.ncbi.nlm.nih.gov/pubmed/30881372
Precision Metagenomics: Rapid Metagenomic Analyses for Infectious Disease Diagnostics and Public Health Surveillance. Afshinnekoo E, Chou C, Alexander N, Ahsanuddin S, Schuetz AN, Mason CE Journal of biomolecular techniques : JBT 28337072 J Biomol Tech 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28337072
Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia. Shih AH, Meydan C, Shank K, Garrett-Bakelman FE, Ward PS, Intlekofer AM, Nazir A, Stein EM, Knapp K, Glass J, Travins J, Straley K, Gliser C, Mason CE, Yen K, Thompson CB, Melnick A, Levine RL Cancer discovery 28193779 Cancer Discov 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28193779
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. Li S, Garrett-Bakelman FE, Chung SS, Sanders MA, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Cannon J, Bullinger L, Luger S, Becker M, Lewis ID, To LB, Delwel R, Löwenberg B, Döhner H, Döhner K, Guzman ML, Hassane DC, Roboz GJ, Grimwade D, Valk PJ, D'Andrea RJ, Carroll M, Park CY, Neuberg D, Levine R, Melnick AM, Mason CE Nature medicine 27322744 Nat Med 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27322744
Ozone Disinfection for Elimination of Bacteria and Degradation of SARS-CoV2 RNA for Medical Environments. Westover C, Rahmatulloev S, Danko D, Afshin EE, O'Hara NB, Ounit R, Bezdan D, Mason CE Genes 36672826 Genes (Basel) 2022 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/36672826
Two methods for full-length RNA sequencing for low quantities of cells and single cells. Pan X, Durrett RE, Zhu H, Tanaka Y, Li Y, Zi X, Marjani SL, Euskirchen G, Ma C, Lamotte RH, Park IH, Snyder MP, Mason CE, Weissman SM Proceedings of the National Academy of Sciences of the United States of America 23267071 Proc Natl Acad Sci U S A 2013 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/23267071
Antiepileptic drugs and pregnancy outcomes. Wlodarczyk BJ, Palacios AM, George TM, Finnell RH American journal of medical genetics. Part A 22711424 Am J Med Genet A 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22711424
Neural tube defects, folate, and immune modulation. Denny KJ, Jeanes A, Fathe K, Finnell RH, Taylor SM, Woodruff TM Birth defects research. Part A, Clinical and molecular teratology 24078477 Birth Defects Res A Clin Mol Teratol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/24078477
Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data. Rapaport F, Khanin R, Liang Y, Pirun M, Krek A, Zumbo P, Mason CE, Socci ND, Betel D Genome biology 24020486 Genome Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/24020486
Assessment of pharmacogenomic agreement. Safikhani Z, El-Hachem N, Quevedo R, Smirnov P, Goldenberg A, Juul Birkbak N, Mason C, Hatzis C, Shi L, Aerts HJ, Quackenbush J, Haibe-Kains B F1000Research 27408686 F1000Res 2016 https://www.ncbi.nlm.nih.gov/pubmed/27408686
The Power of Engaging Citizen Scientists for Scientific Progress. Garbarino J, Mason CE Journal of microbiology & biology education 27047581 J Microbiol Biol Educ 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27047581
New Techniques for the Study of Neural Tube Defects. Lei Y, Finnell RH Advanced techniques in biology & medicine 27066597 Adv Tech Biol Med 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/27066597
Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Denny KJ, Kelly CF, Kumar V, Witham KL, Cabrera RM, Finnell RH, Taylor SM, Jeanes A, Woodruff TM Birth defects research. Part A, Clinical and molecular teratology 26900104 Birth Defects Res A Clin Mol Teratol 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26900104
Complex translocation disrupting TCF4 and altering TCF4 isoform expression segregates as mild autosomal dominant intellectual disability. Maduro V, Pusey BN, Cherukuri PF, Atkins P, du Souich C, Rupps R, Limbos M, Adams DR, Bhatt SS, Eydoux P, Links AE, Lehman A, Malicdan MC, Mason CE, Morimoto M, Mullikin JC, Sear A, Van Karnebeek C, Stankiewicz P, Gahl WA, Toro C, Boerkoel CF Orphanet journal of rare diseases 27179618 Orphanet J Rare Dis 2016 May 14 https://www.ncbi.nlm.nih.gov/pubmed/27179618
The Microbe Directory: An annotated, searchable inventory of microbes' characteristics. Shaaban H, Westfall DA, Mohammad R, Danko D, Bezdan D, Afshinnekoo E, Segata N, Mason CE Gates open research 29630066 Gates Open Res 2018 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/29630066
Assessment of REPLI-g Multiple Displacement Whole Genome Amplification (WGA) Techniques for Metagenomic Applications. Ahsanuddin S, Afshinnekoo E, Gandara J, Hakyemezoğlu M, Bezdan D, Minot S, Greenfield N, Mason CE Journal of biomolecular techniques : JBT 28344519 J Biomol Tech 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28344519
Detecting and correcting systematic variation in large-scale RNA sequencing data. Li S, Łabaj PP, Zumbo P, Sykacek P, Shi W, Shi L, Phan J, Wu PY, Wang M, Wang C, Thierry-Mieg D, Thierry-Mieg J, Kreil DP, Mason CE Nature biotechnology 25150837 Nat Biotechnol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25150837
Assessment and improvement of Indian-origin rhesus macaque and Mauritian-origin cynomolgus macaque genome annotations using deep transcriptome sequencing data. Peng X, Pipes L, Xiong H, Green RR, Jones DC, Ruzzo WL, Schroth GP, Mason CE, Palermo RE, Katze MG Journal of medical primatology 24810475 J Med Primatol 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24810475
Identification of novel CELSR1 mutations in spina bifida. Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH PloS one 24632739 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24632739
Systems biology analysis of human genomes points to key pathways conferring spina bifida risk. Aguiar-Pulido V, Wolujewicz P, Martinez-Fundichely A, Elhaik E, Thareja G, Abdel Aleem A, Chalhoub N, Cuykendall T, Al-Zamer J, Lei Y, El-Bashir H, Musser JM, Al-Kaabi A, Shaw GM, Khurana E, Suhre K, Mason CE, Elemento O, Finnell RH, Ross ME Proceedings of the National Academy of Sciences of the United States of America 34916285 Proc Natl Acad Sci U S A 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34916285
Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity. Gertz ML, Chin CR, Tomoiaga D, MacKay M, Chang C, Butler D, Afshinnekoo E, Bezdan D, Schmidt MA, Mozsary C, Melnick A, Garrett-Bakelman F, Crucian B, Lee SMC, Zwart SR, Smith SM, Meydan C, Mason CE Cell reports 33242408 Cell Rep 2020 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/33242408
CIC missense variants contribute to susceptibility for spina bifida. Han X, Cao X, Aguiar-Pulido V, Yang W, Karki M, Ramirez PAP, Cabrera RM, Lin YL, Wlodarczyk BJ, Shaw GM, Ross ME, Zhang C, Finnell RH, Lei Y Human mutation 36054333 Hum Mutat 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36054333
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Akalin A, Kormaksson M, Li S, Garrett-Bakelman FE, Figueroa ME, Melnick A, Mason CE Genome biology 23034086 Genome Biol 2012 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/23034086
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR Cell 22608085 Cell 2012 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/22608085
The non-human primate reference transcriptome resource (NHPRTR) for comparative functional genomics. Pipes L, Li S, Bozinoski M, Palermo R, Peng X, Blood P, Kelly S, Weiss JM, Thierry-Mieg J, Thierry-Mieg D, Zumbo P, Chen R, Schroth GP, Mason CE, Katze MG Nucleic acids research 23203872 Nucleic Acids Res 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23203872
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL Cell reports 25482556 Cell Rep 2014 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/25482556
An integrative computational approach for prioritization of genomic variants. Dubchak I, Balasubramanian S, Wang S, Cem M, Sulakhe D, Poliakov A, Börnigen D, Xie B, Taylor A, Ma J, Paciorkowski AR, Mirzaa GM, Dave P, Agam G, Xu J, Al-Gazali L, Mason CE, Ross ME, Maltsev N, Gilliam TC PloS one 25506935 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25506935
Genetic and epigenetic heterogeneity and the impact on cancer relapse. Hassan C, Afshinnekoo E, Li S, Wu S, Mason CE Experimental hematology 28705639 Exp Hematol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28705639
Genomic Methods and Microbiological Technologies for Profiling Novel and Extreme Environments for the Extreme Microbiome Project (XMP). Tighe S, Afshinnekoo E, Rock TM, McGrath K, Alexander N, McIntyre A, Ahsanuddin S, Bezdan D, Green SJ, Joye S, Stewart Johnson S, Baldwin DA, Bivens N, Ajami N, Carmical JR, Herriott IC, Colwell R, Donia M, Foox J, Greenfield N, Hunter T, Hoffman J, Hyman J, Jorgensen E, Krawczyk D, Lee J, Levy S, Garcia-Reyero N, Settles M, Thomas K, Gómez F, Schriml L, Kyrpides N, Zaikova E, Penterman J, Mason CE Journal of biomolecular techniques : JBT 28337070 J Biomol Tech 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28337070
Analysis of archived residual newborn screening blood spots after whole genome amplification. Cantarel BL, Lei Y, Weaver D, Zhu H, Farrell A, Benstead-Hume G, Reese J, Finnell RH BMC genomics 26268606 BMC Genomics 2015 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/26268606
Extensive sequencing of seven human genomes to characterize benchmark reference materials. Zook JM, Catoe D, McDaniel J, Vang L, Spies N, Sidow A, Weng Z, Liu Y, Mason CE, Alexander N, Henaff E, McIntyre AB, Chandramohan D, Chen F, Jaeger E, Moshrefi A, Pham K, Stedman W, Liang T, Saghbini M, Dzakula Z, Hastie A, Cao H, Deikus G, Schadt E, Sebra R, Bashir A, Truty RM, Chang CC, Gulbahce N, Zhao K, Ghosh S, Hyland F, Fu Y, Chaisson M, Xiao C, Trow J, Sherry ST, Zaranek AW, Ball M, Bobe J, Estep P, Church GM, Marks P, Kyriazopoulou-Panagiotopoulou S, Zheng GX, Schnall-Levin M, Ordonez HS, Mudivarti PA, Giorda K, Sheng Y, Rypdal KB, Salit M Scientific data 27271295 Sci Data 2016 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/27271295
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Gokhale NS, McIntyre ABR, McFadden MJ, Roder AE, Kennedy EM, Gandara JA, Hopcraft SE, Quicke KM, Vazquez C, Willer J, Ilkayeva OR, Law BA, Holley CL, Garcia-Blanco MA, Evans MJ, Suthar MS, Bradrick SS, Mason CE, Horner SM Cell host & microbe 27773535 Cell Host Microbe 2016 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/27773535
Mutations in planar cell polarity gene SCRIB are associated with spina bifida. Lei Y, Zhu H, Duhon C, Yang W, Ross ME, Shaw GM, Finnell RH PloS one 23922697 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/23922697
The pivotal regulatory landscape of RNA modifications. Li S, Mason CE Annual review of genomics and human genetics 24898039 Annu Rev Genomics Hum Genet 2014 https://www.ncbi.nlm.nih.gov/pubmed/24898039
Genome-wide investigation identifies a rare copy-number variant burden associated with human spina bifida. Wolujewicz P, Aguiar-Pulido V, AbdelAleem A, Nair V, Thareja G, Suhre K, Shaw GM, Finnell RH, Elemento O, Ross ME Genetics in medicine : official journal of the American College of Medical Genetics 33686259 Genet Med 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33686259
Performance evaluation of high-volume electret filter air samplers in aerosol microbiome research. Bøifot KO, Gohli J, Skogan G, Dybwad M Environmental microbiome 33902714 Environ Microbiome 2020 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/33902714
Performance assessment of DNA sequencing platforms in the ABRF Next-Generation Sequencing Study. Foox J, Tighe SW, Nicolet CM, Zook JM, Byrska-Bishop M, Clarke WE, Khayat MM, Mahmoud M, Laaguiby PK, Herbert ZT, Warner D, Grills GS, Jen J, Levy S, Xiang J, Alonso A, Zhao X, Zhang W, Teng F, Zhao Y, Lu H, Schroth GP, Narzisi G, Farmerie W, Sedlazeck FJ, Baldwin DA, Mason CE Nature biotechnology 34504351 Nat Biotechnol 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34504351
Characterization of the public transit air microbiome and resistome reveals geographical specificity. Leung MHY, Tong X, Bøifot KO, Bezdan D, Butler DJ, Danko DC, Gohli J, Green DC, Hernandez MT, Kelly FJ, Levy S, Mason-Buck G, Nieto-Caballero M, Syndercombe-Court D, Udekwu K, Young BG, Mason CE, Dybwad M, Lee PKH Microbiome 34039416 Microbiome 2021 May 26 https://www.ncbi.nlm.nih.gov/pubmed/34039416
Molecular-level functional magnetic resonance imaging of dopaminergic signaling. Lee T, Cai LX, Lelyveld VS, Hai A, Jasanoff A Science (New York, N.Y.) 24786083 Science 2014 May 2 https://www.ncbi.nlm.nih.gov/pubmed/24786083
Metalloprotein-based MRI probes. Matsumoto Y, Jasanoff A FEBS letters 23376346 FEBS Lett 2013 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/23376346
Molecular imaging with engineered physiology. Desai M, Slusarczyk AL, Chapin A, Barch M, Jasanoff A Nature communications 27910951 Nat Commun 2016 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/27910951
Molecular fMRI of Serotonin Transport. Hai A, Cai LX, Lee T, Lelyveld VS, Jasanoff A Neuron 27773583 Neuron 2016 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/27773583
Magnetic Detection of Neural Activity by Nanocoil Transducers. Bok I, Phillips J, Zhu T, Lu J, Detienne E, Lima EA, Weiss BP, Jasanoff A, Hai A Nano letters 39319575 Nano Lett 2024 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/39319575
Magnetic nanosensors optimized for rapid and reversible self-assembly. Rodriguez E, Lelyveld VS, Atanasijevic T, Okada S, Jasanoff A Chemical communications (Cambridge, England) 24566735 Chem Commun (Camb) 2014 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/24566735
Screen-based analysis of magnetic nanoparticle libraries formed using peptidic iron oxide ligands. Barch M, Okada S, Bartelle BB, Jasanoff A Journal of the American Chemical Society 25158100 J Am Chem Soc 2014 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/25158100
Wireless resonant circuits for the minimally invasive sensing of biophysical processes in magnetic resonance imaging. Hai A, Spanoudaki VC, Bartelle BB, Jasanoff A Nature biomedical engineering 30932065 Nat Biomed Eng 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30932065
Magneto-fluorescent core-shell supernanoparticles. Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG Nature communications 25298155 Nat Commun 2014 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/25298155
Adventures in neurobioengineering. Jasanoff A ACS chemical neuroscience 22896800 ACS Chem Neurosci 2012 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/22896800
Engineering intracellular biomineralization and biosensing by a magnetic protein. Matsumoto Y, Chen R, Anikeeva P, Jasanoff A Nature communications 26522873 Nat Commun 2015 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/26522873
A freely-moving monkey treadmill model. Foster JD, Nuyujukian P, Freifeld O, Gao H, Walker R, I Ryu S, H Meng T, Murmann B, J Black M, Shenoy KV Journal of neural engineering 24995476 J Neural Eng 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24995476
Single-trial dynamics of motor cortex and their applications to brain-machine interfaces. Kao JC, Nuyujukian P, Ryu SI, Churchland MM, Cunningham JP, Shenoy KV Nature communications 26220660 Nat Commun 2015 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/26220660
Motor Cortical Visuomotor Feedback Activity Is Initially Isolated from Downstream Targets in Output-Null Neural State Space Dimensions. Stavisky SD, Kao JC, Ryu SI, Shenoy KV Neuron 28625485 Neuron 2017 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/28625485
Inferring single-trial neural population dynamics using sequential auto-encoders. Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D Nature methods 30224673 Nat Methods 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30224673
Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements. Stavisky SD, Kao JC, Nuyujukian P, Pandarinath C, Blabe C, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV Scientific reports 30397281 Sci Rep 2018 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/30397281
Augmenting intracortical brain-machine interface with neurally driven error detectors. Even-Chen N, Stavisky SD, Kao JC, Ryu SI, Shenoy KV Journal of neural engineering 29130452 J Neural Eng 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29130452
Structure in Neural Activity during Observed and Executed Movements Is Shared at the Neural Population Level, Not in Single Neurons. Jiang X, Saggar H, Ryu SI, Shenoy KV, Kao JC Cell reports 32783934 Cell Rep 2020 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/32783934
Self-recalibrating classifiers for intracortical brain-computer interfaces. Bishop W, Chestek CC, Gilja V, Nuyujukian P, Foster JD, Ryu SI, Shenoy KV, Yu BM Journal of neural engineering 24503597 J Neural Eng 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24503597
Intention estimation in brain-machine interfaces. Fan JM, Nuyujukian P, Kao JC, Chestek CA, Ryu SI, Shenoy KV Journal of neural engineering 24654266 J Neural Eng 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24654266
Performance sustaining intracortical neural prostheses. Nuyujukian P, Kao JC, Fan JM, Stavisky SD, Ryu SI, Shenoy KV Journal of neural engineering 25307561 J Neural Eng 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25307561
Discovering Precise Temporal Patterns in Large-Scale Neural Recordings through Robust and Interpretable Time Warping. Williams AH, Poole B, Maheswaranathan N, Dhawale AK, Fisher T, Wilson CD, Brann DH, Trautmann EM, Ryu S, Shusterman R, Rinberg D, Ölveczky BP, Shenoy KV, Ganguli S Neuron 31786013 Neuron 2020 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/31786013
Accurate Estimation of Neural Population Dynamics without Spike Sorting. Trautmann EM, Stavisky SD, Lahiri S, Ames KC, Kaufman MT, O'Shea DJ, Vyas S, Sun X, Ryu SI, Ganguli S, Shenoy KV Neuron 31171448 Neuron 2019 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/31171448
Trial-by-Trial Motor Cortical Correlates of a Rapidly Adapting Visuomotor Internal Model. Stavisky SD, Kao JC, Ryu SI, Shenoy KV The Journal of neuroscience : the official journal of the Society for Neuroscience 28087767 J Neurosci 2017 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/28087767
Leveraging neural dynamics to extend functional lifetime of brain-machine interfaces. Kao JC, Ryu SI, Shenoy KV Scientific reports 28784984 Sci Rep 2017 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/28784984
A recurrent neural network for closed-loop intracortical brain-machine interface decoders. Sussillo D, Nuyujukian P, Fan JM, Kao JC, Stavisky SD, Ryu S, Shenoy K Journal of neural engineering 22427488 J Neural Eng 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22427488
Design and validation of a real-time spiking-neural-network decoder for brain-machine interfaces. Dethier J, Nuyujukian P, Ryu SI, Shenoy KV, Boahen K Journal of neural engineering 23574919 J Neural Eng 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23574919
Structure and variability of delay activity in premotor cortex. Even-Chen N, Sheffer B, Vyas S, Ryu SI, Shenoy KV PLoS computational biology 30794541 PLoS Comput Biol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30794541
Tensor Analysis Reveals Distinct Population Structure that Parallels the Different Computational Roles of Areas M1 and V1. Seely JS, Kaufman MT, Ryu SI, Shenoy KV, Cunningham JP, Churchland MM PLoS computational biology 27814353 PLoS Comput Biol 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27814353
Combining Wireless Neural Recording and Video Capture for the Analysis of Natural Gait. Foster JD, Freifeld O, Nuyujukian P, Ryu SI, Black MJ, Shenoy KV International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering 26019730 Int IEEE EMBS Conf Neural Eng 2011 Apr-May https://www.ncbi.nlm.nih.gov/pubmed/26019730
A High-Performance Neural Prosthesis Incorporating Discrete State Selection With Hidden Markov Models. Kao JC, Nuyujukian P, Ryu SI, Shenoy KV IEEE transactions on bio-medical engineering 27337709 IEEE Trans Biomed Eng 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/27337709
Neural Population Dynamics Underlying Motor Learning Transfer. Vyas S, Even-Chen N, Stavisky SD, Ryu SI, Nuyujukian P, Shenoy KV Neuron 29456026 Neuron 2018 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/29456026
Simultaneous motor preparation and execution in a last-moment reach correction task. Ames KC, Ryu SI, Shenoy KV Nature communications 31221968 Nat Commun 2019 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/31221968
Combining decoder design and neural adaptation in brain-machine interfaces. Shenoy KV, Carmena JM Neuron 25459407 Neuron 2014 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/25459407
A high-performance keyboard neural prosthesis enabled by task optimization. Nuyujukian P, Fan JM, Kao JC, Ryu SI, Shenoy KV IEEE transactions on bio-medical engineering 25203982 IEEE Trans Biomed Eng 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25203982
Spiking Neural Network Decoder for Brain-Machine Interfaces. Dethier J, Gilja V, Nuyujukian P, Elassaad SA, Shenoy KV, Boahen K International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering 24352611 Int IEEE EMBS Conf Neural Eng 2011 https://www.ncbi.nlm.nih.gov/pubmed/24352611
A neural network that finds a naturalistic solution for the production of muscle activity. Sussillo D, Churchland MM, Kaufman MT, Shenoy KV Nature neuroscience 26075643 Nat Neurosci 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26075643
Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control. Stavisky SD, Willett FR, Avansino DT, Hochberg LR, Shenoy KV, Henderson JM Journal of neural engineering 32023225 J Neural Eng 2020 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/32023225
High-fidelity musculoskeletal modeling reveals that motor planning variability contributes to the speed-accuracy tradeoff. Al Borno M, Vyas S, Shenoy KV, Delp SL eLife 33325369 Elife 2020 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/33325369
Studying brain organization via spontaneous fMRI signal. Power JD, Schlaggar BL, Petersen SE Neuron 25459408 Neuron 2014 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/25459408
ERAASR: an algorithm for removing electrical stimulation artifacts from multielectrode array recordings. O'Shea DJ, Shenoy KV Journal of neural engineering 29265009 J Neural Eng 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29265009
Unsupervised Discovery of Demixed, Low-Dimensional Neural Dynamics across Multiple Timescales through Tensor Component Analysis. Williams AH, Kim TH, Wang F, Vyas S, Ryu SI, Shenoy KV, Schnitzer M, Kolda TG, Ganguli S Neuron 29887338 Neuron 2018 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/29887338
A high performing brain-machine interface driven by low-frequency local field potentials alone and together with spikes. Stavisky SD, Kao JC, Nuyujukian P, Ryu SI, Shenoy KV Journal of neural engineering 25946198 J Neural Eng 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25946198
Hybrid decoding of both spikes and low-frequency local field potentials for brain-machine interfaces. Stavisky SD, Kao JC, Nuyujukian P, Ryu SI, Shenoy KV Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 25570632 Annu Int Conf IEEE Eng Med Biol Soc 2014 https://www.ncbi.nlm.nih.gov/pubmed/25570632
Auto-deleting brain machine interface: Error detection using spiking neural activity in the motor cortex. Even-Chen N, Stavisky SD, Kao JC, Ryu SI, Shenoy KV Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 26736203 Annu Int Conf IEEE Eng Med Biol Soc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26736203
Leveraging historical knowledge of neural dynamics to rescue decoder performance as neural channels are lost: "Decoder hysteresis". Kao JC, Ryu SI, Shenoy KV Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 26736448 Annu Int Conf IEEE Eng Med Biol Soc 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26736448
A Brain-Machine Interface Operating with a Real-Time Spiking Neural Network Control Algorithm. Dethier J, Nuyujukian P, Eliasmith C, Stewart T, Elassaad SA, Shenoy KV, Boahen K Advances in neural information processing systems 25309106 Adv Neural Inf Process Syst 2011 https://www.ncbi.nlm.nih.gov/pubmed/25309106
Selective modulation of cortical state during spatial attention. Engel TA, Steinmetz NA, Gieselmann MA, Thiele A, Moore T, Boahen K Science (New York, N.Y.) 27934763 Science 2016 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/27934763
A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain-machine interfaces. Nason SR, Vaskov AK, Willsey MS, Welle EJ, An H, Vu PP, Bullard AJ, Nu CS, Kao JC, Shenoy KV, Jang T, Kim HS, Blaauw D, Patil PG, Chestek CA Nature biomedical engineering 32719512 Nat Biomed Eng 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32719512
In vivo generation of DNA sequence diversity for cellular barcoding. Peikon ID, Gizatullina DI, Zador AM Nucleic acids research 25013177 Nucleic Acids Res 2014 https://www.ncbi.nlm.nih.gov/pubmed/25013177
Long-term Cre-mediated retrograde tagging of neurons using a novel recombinant pseudorabies virus. Oyibo HK, Znamenskiy P, Oviedo HV, Enquist LW, Zador AM Frontiers in neuroanatomy 25232307 Front Neuroanat 2014 https://www.ncbi.nlm.nih.gov/pubmed/25232307
Sequencing the connectome. Zador AM, Dubnau J, Oyibo HK, Zhan H, Cao G, Peikon ID PLoS biology 23109909 PLoS Biol 2012 https://www.ncbi.nlm.nih.gov/pubmed/23109909
BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Huang L, Kebschull JM, Fürth D, Musall S, Kaufman MT, Churchland AK, Zador AM Cell 32619423 Cell 2020 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/32619423
The logic of single-cell projections from visual cortex. Han Y, Kebschull JM, Campbell RAA, Cowan D, Imhof F, Zador AM, Mrsic-Flogel TD Nature 29590093 Nature 2018 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/29590093
BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Huang L, Kebschull JM, Fürth D, Musall S, Kaufman MT, Churchland AK, Zador AM Cell 33357401 Cell 2020 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/33357401
Cellular anatomy of the mouse primary motor cortex. Muñoz-Castañeda R, Zingg B, Matho KS, Chen X, Wang Q, Foster NN, Li A, Narasimhan A, Hirokawa KE, Huo B, Bannerjee S, Korobkova L, Park CS, Park YG, Bienkowski MS, Chon U, Wheeler DW, Li X, Wang Y, Naeemi M, Xie P, Liu L, Kelly K, An X, Attili SM, Bowman I, Bludova A, Cetin A, Ding L, Drewes R, D'Orazi F, Elowsky C, Fischer S, Galbavy W, Gao L, Gillis J, Groblewski PA, Gou L, Hahn JD, Hatfield JT, Hintiryan H, Huang JJ, Kondo H, Kuang X, Lesnar P, Li X, Li Y, Lin M, Lo D, Mizrachi J, Mok S, Nicovich PR, Palaniswamy R, Palmer J, Qi X, Shen E, Sun YC, Tao HW, Wakemen W, Wang Y, Yao S, Yuan J, Zhan H, Zhu M, Ng L, Zhang LI, Lim BK, Hawrylycz M, Gong H, Gee JC, Kim Y, Chung K, Yang XW, Peng H, Luo Q, Mitra PP, Zador AM, Zeng H, Ascoli GA, Josh Huang Z, Osten P, Harris JA, Dong HW Nature 34616071 Nature 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34616071
Whole-cortex in situ sequencing reveals input-dependent area identity. Chen X, Fischer S, Rue MCP, Zhang A, Mukherjee D, Kanold PO, Gillis J, Zador AM Nature 38658747 Nature 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/38658747
Assessing the replicability of spatial gene expression using atlas data from the adult mouse brain. Lu S, Ortiz C, Fürth D, Fischer S, Meletis K, Zador A, Gillis J PLoS biology 34280183 PLoS Biol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34280183
A New Defective Helper RNA to Produce Recombinant Sindbis Virus that Infects Neurons but does not Propagate. Kebschull JM, Garcia da Silva P, Zador AM Frontiers in neuroanatomy 27252627 Front Neuroanat 2016 https://www.ncbi.nlm.nih.gov/pubmed/27252627
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections. Sun YC, Chen X, Fischer S, Lu S, Zhan H, Gillis J, Zador AM Nature neuroscience 33972801 Nat Neurosci 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33972801
BARcode DEmixing through Non-negative Spatial Regression (BarDensr). Chen S, Loper J, Chen X, Vaughan A, Zador AM, Paninski L PLoS computational biology 33684106 PLoS Comput Biol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33684106
High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA. Kebschull JM, Garcia da Silva P, Reid AP, Peikon ID, Albeanu DF, Zador AM Neuron 27545715 Neuron 2016 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/27545715
Sources of PCR-induced distortions in high-throughput sequencing data sets. Kebschull JM, Zador AM Nucleic acids research 26187991 Nucleic Acids Res 2015 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/26187991
High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing. Chen X, Sun YC, Zhan H, Kebschull JM, Fischer S, Matho K, Huang ZJ, Gillis J, Zador AM Cell 31626774 Cell 2019 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/31626774
SYNPLA, a method to identify synapses displaying plasticity after learning. Dore K, Pao Y, Soria Lopez J, Aronson S, Zhan H, Ghosh S, Merrill S, Zador AM, Malinow R, Kebschull JM Proceedings of the National Academy of Sciences of the United States of America 31974314 Proc Natl Acad Sci U S A 2020 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/31974314
Fully automated cellular-resolution vertebrate screening platform with parallel animal processing. Chang TY, Pardo-Martin C, Allalou A, Wählby C, Yanik MF Lab on a chip 22159032 Lab Chip 2012 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/22159032
Organ-targeted high-throughput in vivo biologics screen identifies materials for RNA delivery. Chang TY, Shi P, Steinmeyer JD, Chatnuntawech I, Tillberg P, Love KT, Eimon PM, Anderson DG, Yanik MF Integrative biology : quantitative biosciences from nano to macro 25184623 Integr Biol (Camb) 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25184623
Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects. Eimon PM, Ghannad-Rezaie M, De Rienzo G, Allalou A, Wu Y, Gao M, Roy A, Skolnick J, Yanik MF Nature communications 29335539 Nat Commun 2018 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/29335539
Computer-Assisted Transgenesis of Caenorhabditis elegans for Deep Phenotyping. Gilleland CL, Falls AT, Noraky J, Heiman MG, Yanik MF Genetics 26163188 Genetics 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26163188
Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders. Ghannad-Rezaie M, Eimon PM, Wu Y, Yanik MF Nature communications 31197165 Nat Commun 2019 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/31197165
Studying apoptosis in the Zebrafish. Eimon PM Methods in enzymology 24974299 Methods Enzymol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24974299
High-throughput in vivo vertebrate screening. Pardo-Martin C, Chang TY, Koo BK, Gilleland CL, Wasserman SC, Yanik MF Nature methods 20639868 Nat Methods 2010 Aug https://www.ncbi.nlm.nih.gov/pubmed/20639868
High-throughput hyperdimensional vertebrate phenotyping. Pardo-Martin C, Allalou A, Medina J, Eimon PM, Wählby C, Fatih Yanik M Nature communications 23403568 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23403568
Cortical correlates of fitts' law. Ifft PJ, Lebedev MA, Nicolelis MA Frontiers in integrative neuroscience 22275888 Front Integr Neurosci 2011 https://www.ncbi.nlm.nih.gov/pubmed/22275888
Building an organic computing device with multiple interconnected brains. Pais-Vieira M, Chiuffa G, Lebedev M, Yadav A, Nicolelis MA Scientific reports 26158615 Sci Rep 2015 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/26158615
Simultaneous top-down modulation of the primary somatosensory cortex and thalamic nuclei during active tactile discrimination. Pais-Vieira M, Lebedev MA, Wiest MC, Nicolelis MA The Journal of neuroscience : the official journal of the Society for Neuroscience 23447616 J Neurosci 2013 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/23447616
Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease. Santana MB, Halje P, Simplício H, Richter U, Freire MAM, Petersson P, Fuentes R, Nicolelis MAL Neuron 25447740 Neuron 2014 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/25447740
Cortical and thalamic contributions to response dynamics across layers of the primary somatosensory cortex during tactile discrimination. Pais-Vieira M, Kunicki C, Tseng PH, Martin J, Lebedev M, Nicolelis MA Journal of neurophysiology 26180115 J Neurophysiol 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26180115
A Brain to Spine Interface for Transferring Artificial Sensory Information. Yadav AP, Li D, Nicolelis MAL Scientific reports 31964948 Sci Rep 2020 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/31964948
Reprogramming movements: extraction of motor intentions from cortical ensemble activity when movement goals change. Ifft PJ, Lebedev MA, Nicolelis MA Frontiers in neuroengineering 22826698 Front Neuroeng 2012 https://www.ncbi.nlm.nih.gov/pubmed/22826698
Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions. Yadav AP, Fuentes R, Zhang H, Vinholo T, Wang CH, Freire MA, Nicolelis MA Scientific reports 24452435 Sci Rep 2014 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/24452435
Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients. Hanson TL, Fuller AM, Lebedev MA, Turner DA, Nicolelis MA The Journal of neuroscience : the official journal of the Society for Neuroscience 22723703 J Neurosci 2012 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/22723703
Active tactile exploration using a brain-machine-brain interface. O'Doherty JE, Lebedev MA, Ifft PJ, Zhuang KZ, Shokur S, Bleuler H, Nicolelis MA Nature 21976021 Nature 2011 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/21976021
A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Pais-Vieira M, Yadav AP, Moreira D, Guggenmos D, Santos A, Lebedev M, Nicolelis MAL Scientific reports 27605389 Sci Rep 2016 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/27605389
Neural integration of reward, arousal, and feeding: recruitment of VTA, lateral hypothalamus, and ventral striatal neurons. Gutierrez R, Lobo MK, Zhang F, de Lecea L IUBMB life 21901814 IUBMB Life 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21901814
Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo. Rouaux C, Arlotta P Nature cell biology 23334497 Nat Cell Biol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23334497
DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Molyneaux BJ, Goff LA, Brettler AC, Chen HH, Hrvatin S, Rinn JL, Arlotta P Neuron 25556833 Neuron 2015 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/25556833
Multiplex genome engineering using CRISPR/Cas systems. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F Science (New York, N.Y.) 23287718 Science 2013 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/23287718
A transcription activator-like effector toolbox for genome engineering. Sanjana NE, Cong L, Zhou Y, Cunniff MM, Feng G, Zhang F Nature protocols 22222791 Nat Protoc 2012 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/22222791
Cell diversity and network dynamics in photosensitive human brain organoids. Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Min Yang S, Berger DR, Maria N, Scholvin J, Goldman M, Kinney JP, Boyden ES, Lichtman JW, Williams ZM, McCarroll SA, Arlotta P Nature 28445462 Nature 2017 May 4 https://www.ncbi.nlm.nih.gov/pubmed/28445462
Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL eLife 24381249 Elife 2013 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/24381249
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Zhang F, Cong L, Lodato S, Kosuri S, Church GM, Arlotta P Nature biotechnology 21248753 Nat Biotechnol 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21248753
RNA-guided genome editing of mammalian cells. Pyzocha NK, Ran FA, Hsu PD, Zhang F Methods in molecular biology (Clifton, N.J.) 24557909 Methods Mol Biol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24557909
Optical control of mammalian endogenous transcription and epigenetic states. Konermann S, Brigham MD, Trevino A, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F Nature 23877069 Nature 2013 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/23877069
CRISPR RNA-guided activation of endogenous human genes. Maeder ML, Linder SJ, Cascio VM, Fu Y, Ho QH, Joung JK Nature methods 23892898 Nat Methods 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23892898
Development and applications of CRISPR-Cas9 for genome engineering. Hsu PD, Lander ES, Zhang F Cell 24906146 Cell 2014 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/24906146
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Cong L, Zhou R, Kuo YC, Cunniff M, Zhang F Nature communications 22828628 Nat Commun 2012 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/22828628
Dissecting neural function using targeted genome engineering technologies. Hsu PD, Zhang F ACS chemical neuroscience 22896804 ACS Chem Neurosci 2012 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/22896804
Robust, synergistic regulation of human gene expression using TALE activators. Maeder ML, Linder SJ, Reyon D, Angstman JF, Fu Y, Sander JD, Joung JK Nature methods 23396285 Nat Methods 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23396285
Therapeutic genome editing: prospects and challenges. Cox DB, Platt RJ, Zhang F Nature medicine 25654603 Nat Med 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25654603
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Ramanan V, Shlomai A, Cox DB, Schwartz RE, Michailidis E, Bhatta A, Scott DA, Zhang F, Rice CM, Bhatia SN Scientific reports 26035283 Sci Rep 2015 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/26035283
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. Swiech L, Heidenreich M, Banerjee A, Habib N, Li Y, Trombetta J, Sur M, Zhang F Nature biotechnology 25326897 Nat Biotechnol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25326897
Chemosensory organs as models of neuronal synapses. Shaham S Nature reviews. Neuroscience 20029439 Nat Rev Neurosci 2010 Mar https://www.ncbi.nlm.nih.gov/pubmed/20029439
Two novel DEG/ENaC channel subunits expressed in glia are needed for nose-touch sensitivity in Caenorhabditis elegans. Han L, Wang Y, Sangaletti R, D'Urso G, Lu Y, Shaham S, Bianchi L The Journal of neuroscience : the official journal of the Society for Neuroscience 23325233 J Neurosci 2013 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/23325233
FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis. Kelley M, Yochem J, Krieg M, Calixto A, Heiman MG, Kuzmanov A, Meli V, Chalfie M, Goodman MB, Shaham S, Frand A, Fay DS eLife 25798732 Elife 2015 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/25798732
Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans. Rapti G, Li C, Shan A, Lu Y, Shaham S Nature neuroscience 28846083 Nat Neurosci 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28846083
Stress. Procko C, Shaham S Current biology : CB 22115453 Curr Biol 2011 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/22115453
Opposing activities of LIT-1/NLK and DAF-6/patched-related direct sensory compartment morphogenesis in C. elegans. Oikonomou G, Perens EA, Lu Y, Watanabe S, Jorgensen EM, Shaham S PLoS biology 21857800 PLoS Biol 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21857800
Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Gao YJ, Ji RR Pharmacology & therapeutics 20117131 Pharmacol Ther 2010 Apr https://www.ncbi.nlm.nih.gov/pubmed/20117131
Targeting microglial purinergic signaling to improve morphine analgesia. Ji RR Pain 20584568 Pain 2010 Sep https://www.ncbi.nlm.nih.gov/pubmed/20584568
Microglia and spinal cord synaptic plasticity in persistent pain. Taves S, Berta T, Chen G, Ji RR Neural plasticity 24024042 Neural Plast 2013 https://www.ncbi.nlm.nih.gov/pubmed/24024042
New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? Liu T, Ji RR Pflugers Archiv : European journal of physiology 23636773 Pflugers Arch 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23636773
Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. Berta T, Park CK, Xu ZZ, Xie RG, Liu T, Lü N, Liu YC, Ji RR The Journal of clinical investigation 24531553 J Clin Invest 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24531553
Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN Advances in nutrition (Bethesda, Md.) 22332103 Adv Nutr 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22332103
Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. Xu ZZ, Berta T, Ji RR Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 22878925 J Neuroimmune Pharmacol 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/22878925
Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. Park CK, Xu ZZ, Liu T, Lü N, Serhan CN, Ji RR The Journal of neuroscience : the official journal of the Society for Neuroscience 22171045 J Neurosci 2011 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/22171045
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22253477 FASEB J 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22253477
Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN The Journal of biological chemistry 21757729 J Biol Chem 2011 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/21757729
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. Chen G, Xie RG, Gao YJ, Xu ZZ, Zhao LX, Bang S, Berta T, Park CK, Lay M, Chen W, Ji RR Nature communications 27538456 Nat Commun 2016 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/27538456
Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion. Chen G, Park CK, Xie RG, Ji RR The Journal of clinical investigation 26168219 J Clin Invest 2015 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/26168219
Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions. Liu CC, Gao YJ, Luo H, Berta T, Xu ZZ, Ji RR, Tan PH Scientific reports 27670299 Sci Rep 2016 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/27670299
Emerging targets in neuroinflammation-driven chronic pain. Ji RR, Xu ZZ, Gao YJ Nature reviews. Drug discovery 24948120 Nat Rev Drug Discov 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24948120
Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch. Ji RR Annual review of pharmacology and toxicology 36100219 Annu Rev Pharmacol Toxicol 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36100219
Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. Park CK, Lü N, Xu ZZ, Liu T, Serhan CN, Ji RR The Journal of neuroscience : the official journal of the Society for Neuroscience 22016541 J Neurosci 2011 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/22016541
Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. Zhang ZJ, Cao DL, Zhang X, Ji RR, Gao YJ Pain 23831863 Pain 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23831863
Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Gao YJ, Zhang L, Ji RR Glia 20737477 Glia 2010 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/20737477
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Xu ZZ, Zhang L, Liu T, Park JY, Berta T, Yang R, Serhan CN, Ji RR Nature medicine 20383154 Nat Med 2010 May https://www.ncbi.nlm.nih.gov/pubmed/20383154
Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia. Gao YJ, Ji RR Journal of neurochemistry 20722971 J Neurochem 2010 Oct https://www.ncbi.nlm.nih.gov/pubmed/20722971
Resolvins are potent analgesics for arthritic pain. Xu ZZ, Ji RR British journal of pharmacology 21418190 Br J Pharmacol 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21418190
Toll-like receptor 7 mediates pruritus. Liu T, Xu ZZ, Park CK, Berta T, Ji RR Nature neuroscience 21037581 Nat Neurosci 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/21037581
TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. Zhang L, Berta T, Xu ZZ, Liu T, Park JY, Ji RR Pain 21159431 Pain 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21159431
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN American journal of physiology. Cell physiology 24696140 Am J Physiol Cell Physiol 2014 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/24696140
Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. Martini AC, Berta T, Forner S, Chen G, Bento AF, Ji RR, Rae GA Journal of neuroinflammation 27059991 J Neuroinflammation 2016 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/27059991
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G Proceedings of the National Academy of Sciences of the United States of America 27791151 Proc Natl Acad Sci U S A 2016 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/27791151
Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. Suter MR, Berta T, Gao YJ, Decosterd I, Ji RR Molecular pain 19772627 Mol Pain 2009 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/19772627
The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition. Gao YJ, Xu ZZ, Liu YC, Wen YR, Decosterd I, Ji RR Pain 20022176 Pain 2010 Feb https://www.ncbi.nlm.nih.gov/pubmed/20022176
Targeting astrocyte signaling for chronic pain. Gao YJ, Ji RR Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20880510 Neurotherapeutics 2010 Oct https://www.ncbi.nlm.nih.gov/pubmed/20880510
Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. Liu YC, Berta T, Liu T, Tan PH, Ji RR Molecular pain 22444868 Mol Pain 2012 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/22444868
Emerging roles of resolvins in the resolution of inflammation and pain. Ji RR, Xu ZZ, Strichartz G, Serhan CN Trends in neurosciences 21963090 Trends Neurosci 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21963090
Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. Wen YR, Tan PH, Cheng JK, Liu YC, Ji RR Journal of the Formosan Medical Association = Taiwan yi zhi 21783017 J Formos Med Assoc 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21783017
Glial cells and chronic pain. Gosselin RD, Suter MR, Ji RR, Decosterd I The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 20581331 Neuroscientist 2010 Oct https://www.ncbi.nlm.nih.gov/pubmed/20581331
Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. Berta T, Liu YC, Xu ZZ, Ji RR Neuroscience 23707980 Neuroscience 2013 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/23707980
Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence. Berta T, Qadri YJ, Chen G, Ji RR Journal of dental research 27307048 J Dent Res 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27307048
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Xu ZZ, Kim YH, Bang S, Zhang Y, Berta T, Wang F, Oh SB, Ji RR Nature medicine 26479925 Nat Med 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26479925
Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Park CK, Xu ZZ, Berta T, Han Q, Chen G, Liu XJ, Ji RR Neuron 24698267 Neuron 2014 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/24698267
A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. Lu Y, Dong H, Gao Y, Gong Y, Ren Y, Gu N, Zhou S, Xia N, Sun YY, Ji RR, Xiong L The Journal of clinical investigation 23979158 J Clin Invest 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23979158
Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. Pagadala P, Park CK, Bang S, Xu ZZ, Xie RG, Liu T, Han BX, Tracey WD Jr, Wang F, Ji RR The Journal of neuroscience : the official journal of the Society for Neuroscience 23946399 J Neurosci 2013 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/23946399
Vagus nerve controls resolution and pro-resolving mediators of inflammation. Mirakaj V, Dalli J, Granja T, Rosenberger P, Serhan CN The Journal of experimental medicine 24863066 J Exp Med 2014 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/24863066
Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. Huang L, Wang CF, Serhan CN, Strichartz G Pain 21255928 Pain 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21255928
TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. Liu T, Berta T, Xu ZZ, Park CK, Zhang L, Lü N, Liu Q, Liu Y, Gao YJ, Liu YC, Ma Q, Dong X, Ji RR The Journal of clinical investigation 22565312 J Clin Invest 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22565312
Short small-interfering RNAs produce interferon-α-mediated analgesia. Tan PH, Gao YJ, Berta T, Xu ZZ, Ji RR British journal of anaesthesia 22307241 Br J Anaesth 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22307241
Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. Berta T, Liu T, Liu YC, Xu ZZ, Ji RR Molecular pain 22439811 Mol Pain 2012 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/22439811
Emerging role of Toll-like receptors in the control of pain and itch. Liu T, Gao YJ, Ji RR Neuroscience bulletin 22466124 Neurosci Bull 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22466124
Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. Liu T, Ji RR Neuroscience bulletin 22466125 Neurosci Bull 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22466125
Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. Xu ZZ, Liu XJ, Berta T, Park CK, Lü N, Serhan CN, Ji RR Annals of neurology 23686636 Ann Neurol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23686636
Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. Doyle JR, Krishnaji ST, Zhu G, Xu ZZ, Heller D, Ji RR, Levy BD, Kumar K, Kopin AS The Journal of biological chemistry 24659779 J Biol Chem 2014 May 9 https://www.ncbi.nlm.nih.gov/pubmed/24659779
Glia and pain: is chronic pain a gliopathy? Ji RR, Berta T, Nedergaard M Pain 23792284 Pain 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23792284
A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. Lee JH, Park CK, Chen G, Han Q, Xie RG, Liu T, Ji RR, Lee SY Cell 24856969 Cell 2014 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/24856969
Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Chen G, Park CK, Xie RG, Berta T, Nedergaard M, Ji RR Brain : a journal of neurology 24919967 Brain 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24919967
Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. Liu XJ, Zhang Y, Liu T, Xu ZZ, Park CK, Berta T, Jiang D, Ji RR Cell research 25112711 Cell Res 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25112711
In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription. Askary A, Sanchez-Guardado L, Linton JM, Chadly DM, Budde MW, Cai L, Lois C, Elowitz MB Nature biotechnology 31740838 Nat Biotechnol 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31740838
Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes. Tischbirek CH, Fang L, Chadly DM, Lobbia S, Aguirre JD, Takei Y, Chen CH, Sternberg PW, Lois C, Elowitz MB, Cai L bioRxiv : the preprint server for biology 41404612 bioRxiv 2025 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/41404612
A synthetic protein-level neural network in mammalian cells. Chen Z, Linton JM, Xia S, Fan X, Yu D, Wang J, Zhu R, Elowitz MB Science (New York, N.Y.) 39666795 Science 2024 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/39666795
Contextual computation by competitive protein dimerization networks. Parres-Gold J, Levine M, Emert B, Stuart A, Elowitz MB Cell 39978343 Cell 2025 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/39978343
The computational capabilities of many-to-many protein interaction networks. Klumpe HE, Garcia-Ojalvo J, Elowitz MB, Antebi YE Cell systems 37348461 Cell Syst 2023 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/37348461
Principles of Computation by Competitive Protein Dimerization Networks. Parres-Gold J, Levine M, Emert B, Stuart A, Elowitz MB bioRxiv : the preprint server for biology 37961250 bioRxiv 2024 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37961250
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH. Eng CL, Lawson M, Zhu Q, Dries R, Koulena N, Takei Y, Yun J, Cronin C, Karp C, Yuan GC, Cai L Nature 30911168 Nature 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30911168
Constitutive splicing and economies of scale in gene expression. Ding F, Elowitz MB Nature structural & molecular biology 31133700 Nat Struct Mol Biol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31133700
Synthetic mammalian signaling circuits for robust cell population control. Ma Y, Budde MW, Mayalu MN, Zhu J, Lu AC, Murray RM, Elowitz MB Cell 35235768 Cell 2022 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/35235768
EasyFlow: An open source, user friendly cytometry analyzer with graphic user interface (GUI). Ma Y, Antebi Y bioRxiv : the preprint server for biology 37609189 bioRxiv 2023 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/37609189
Lineage motifs as developmental modules for control of cell type proportions. Tran M, Askary A, Elowitz MB Developmental cell 38359830 Dev Cell 2024 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/38359830
EasyFlow: An open-source, user-friendly cytometry analyzer with graphic user interface (GUI). Ma Y, Eizenberg-Magar I, Antebi Y PloS one 39536028 PLoS One 2024 https://www.ncbi.nlm.nih.gov/pubmed/39536028
Regenerative base editing enables deep lineage recording. Chadly D, Hadas R, Klock L, Yue J, Horns F, Askary A, Granados A, Bouckaert R, Lois C, Cai L, Elowitz MB bioRxiv : the preprint server for biology 41676548 bioRxiv 2026 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/41676548
Contextual computation by competitive protein dimerization networks. Parres-Gold J, Levine M, Emert B, Stuart A, Elowitz MB Cell 41856112 Cell 2026 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/41856112
Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron seqFISH. Shah S, Takei Y, Zhou W, Lubeck E, Yun J, Eng CL, Koulena N, Cronin C, Karp C, Liaw EJ, Amin M, Cai L Cell 29887381 Cell 2018 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/29887381
Programmable protein circuit design. Chen Z, Elowitz MB Cell 33848464 Cell 2021 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/33848464
Imaging cell lineage with a synthetic digital recording system. Chow KK, Budde MW, Granados AA, Cabrera M, Yoon S, Cho S, Huang TH, Koulena N, Frieda KL, Cai L, Lois C, Elowitz MB Science (New York, N.Y.) 33833095 Science 2021 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/33833095
The context-dependent, combinatorial logic of BMP signaling. Klumpe HE, Langley MA, Linton JM, Su CJ, Antebi YE, Elowitz MB Cell systems 35421361 Cell Syst 2022 May 18 https://www.ncbi.nlm.nih.gov/pubmed/35421361
Projection neurons are necessary for the maintenance of the mouse olfactory circuit. Sánchez-Guardado L, Razavi P, Wang B, Callejas-Marín A, Lois C eLife 39671236 Elife 2024 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/39671236
Simultaneous Protein and RNA Analysis in Single Extracellular Vesicles, Including Viruses. Troyer Z, Gololobova O, Koppula A, Liao Z, Horns F, Elowitz MB, Tosar JP, Batish M, Witwer KW ACS nano 39306763 ACS Nano 2024 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/39306763
Ligand-receptor promiscuity enables cellular addressing. Su CJ, Murugan A, Linton JM, Yeluri A, Bois J, Klumpe H, Langley MA, Antebi YE, Elowitz MB Cell systems 35421362 Cell Syst 2022 May 18 https://www.ncbi.nlm.nih.gov/pubmed/35421362
Embryo model completes gastrulation to neurulation and organogenesis. Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz MB, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M Nature 36007540 Nature 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/36007540
Integrated spatial genomics reveals global architecture of single nuclei. Takei Y, Yun J, Zheng S, Ollikainen N, Pierson N, White J, Shah S, Thomassie J, Suo S, Eng CL, Guttman M, Yuan GC, Cai L Nature 33505024 Nature 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33505024
Giotto: a toolbox for integrative analysis and visualization of spatial expression data. Dries R, Zhu Q, Dong R, Eng CL, Li H, Liu K, Fu Y, Zhao T, Sarkar A, Bao F, George RE, Pierson N, Cai L, Yuan GC Genome biology 33685491 Genome Biol 2021 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/33685491
Lineage motifs: developmental modules for control of cell type proportions. Tran M, Askary A, Elowitz MB bioRxiv : the preprint server for biology 37333085 bioRxiv 2023 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/37333085
Engineering RNA export for measurement and manipulation of living cells. Horns F, Martinez JA, Fan C, Haque M, Linton JM, Tobin V, Santat L, Maggiolo AO, Bjorkman PJ, Lois C, Elowitz MB Cell 37437570 Cell 2023 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/37437570
A BODIPY-Based Donor/Donor-Acceptor System: Towards Highly Efficient Long-Wavelength-Excitable Near-IR Polymer Dots with Narrow and Strong Absorption Features. Chen L, Chen D, Jiang Y, Zhang J, Yu J, DuFort CC, Hingorani SR, Zhang X, Wu C, Chiu DT Angewandte Chemie (International ed. in English) 30912228 Angew Chem Int Ed Engl 2019 May 20 https://www.ncbi.nlm.nih.gov/pubmed/30912228
Ratiometric Barcoding for Mass Cytometry. Wu X, DeGottardi Q, Wu IC, Wu L, Yu J, Kwok WW, Chiu DT Analytical chemistry 30139253 Anal Chem 2018 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/30139253
Superresolution imaging of Drosophila tissues using expansion microscopy. Jiang N, Kim HJ, Chozinski TJ, Azpurua JE, Eaton BA, Vaughan JC, Parrish JZ Molecular biology of the cell 29688792 Mol Biol Cell 2018 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/29688792
Volumetric, Nanoscale Optical Imaging of Mouse and Human Kidney via Expansion Microscopy. Chozinski TJ, Mao C, Halpern AR, Pippin JW, Shankland SJ, Alpers CE, Najafian B, Vaughan JC Scientific reports 29991751 Sci Rep 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29991751
The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment. Hardin WR, Alas GCM, Taparia N, Thomas EB, Steele-Ogus MC, Hvorecny KL, Halpern AR, Tůmová P, Kollman JM, Vaughan JC, Sniadecki NJ, Paredez AR PLoS pathogens 35482847 PLoS Pathog 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35482847
Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis. Xie W, Reder NP, Koyuncu C, Leo P, Hawley S, Huang H, Mao C, Postupna N, Kang S, Serafin R, Gao G, Han Q, Bishop KW, Barner LA, Fu P, Wright JL, Keene CD, Vaughan JC, Janowczyk A, Glaser AK, Madabhushi A, True LD, Liu JTC Cancer research 34853071 Cancer Res 2022 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/34853071
Nondestructive 3D Pathology with Light-Sheet Fluorescence Microscopy for Translational Research and Clinical Assays. Liu JTC, Glaser AK, Poudel C, Vaughan JC Annual review of analytical chemistry (Palo Alto, Calif.) 36854208 Annu Rev Anal Chem (Palo Alto Calif) 2023 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/36854208
Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy. Mao C, Lee MY, Jhan JR, Halpern AR, Woodworth MA, Glaser AK, Chozinski TJ, Shin L, Pippin JW, Shankland SJ, Liu JTC, Vaughan JC Science advances 32518827 Sci Adv 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32518827
Switchable Fluorophores for Single-Molecule Localization Microscopy. Li H, Vaughan JC Chemical reviews 30221931 Chem Rev 2018 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/30221931
A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. Jiang N, Rasmussen JP, Clanton JA, Rosenberg MF, Luedke KP, Cronan MR, Parker ED, Kim HJ, Vaughan JC, Sagasti A, Parrish JZ eLife 30855229 Elife 2019 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/30855229
Extended-Depth 3D Super-Resolution Imaging Using Probe-Refresh STORM. Lin D, Gagnon LA, Howard MD, Halpern AR, Vaughan JC Biophysical journal 29694874 Biophys J 2018 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/29694874
Fluorescent labeling of abundant reactive entities (FLARE) for cleared-tissue and super-resolution microscopy. Lee MY, Mao C, Glaser AK, Woodworth MA, Halpern AR, Ali A, Liu JTC, Vaughan JC Nature protocols 35110740 Nat Protoc 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35110740
Ultrabright Pdots with a Large Absorbance Cross Section and High Quantum Yield. Zhang J, Yu J, Jiang Y, Chiu DT ACS applied materials & interfaces 35258939 ACS Appl Mater Interfaces 2022 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/35258939
Microtubule Acetylation Is Required for Mechanosensation in Drosophila. Yan C, Wang F, Peng Y, Williams CR, Jenkins B, Wildonger J, Kim HJ, Perr JB, Vaughan JC, Kern ME, Falvo MR, O'Brien ET 3rd, Superfine R, Tuthill JC, Xiang Y, Rogers SL, Parrish JZ Cell reports 30355484 Cell Rep 2018 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/30355484
Hybrid Structured Illumination Expansion Microscopy Reveals Microbial Cytoskeleton Organization. Halpern AR, Alas GCM, Chozinski TJ, Paredez AR, Vaughan JC ACS nano 29165993 ACS Nano 2017 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/29165993
Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues. Glaser AK, Reder NP, Chen Y, Yin C, Wei L, Kang S, Barner LA, Xie W, McCarty EF, Mao C, Halpern AR, Stoltzfus CR, Daniels JS, Gerner MY, Nicovich PR, Vaughan JC, True LD, Liu JTC Nature communications 31273194 Nat Commun 2019 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/31273194
Versatile, do-it-yourself, low-cost spinning disk confocal microscope. Halpern AR, Lee MY, Howard MD, Woodworth MA, Nicovich PR, Vaughan JC Biomedical optics express 35284165 Biomed Opt Express 2022 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/35284165
BODIPY-based near-infrared semiconducting polymer dot for selective yellow laser-excited cell imaging. Chen L, Jiang Y, Xu S, Zhang J, Jung SR, Yu J, Zhang X, Chiu DT RSC advances 37223645 RSC Adv 2023 May 15 https://www.ncbi.nlm.nih.gov/pubmed/37223645
Error-Correction Method for High-Throughput Sizing of Nanoscale Vesicles with Single-Molecule Localization Microscopy. Jung SR, Kim J, Vojtech L, Vaughan JC, Chiu DT The journal of physical chemistry. B 36944080 J Phys Chem B 2023 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/36944080
Highly multiplexed fluorescence microscopy with spectrally tunable semiconducting polymer dots. Guo Z, Poudel C, Sarfatis MC, Yu J, Wong M, Chiu DT, Vaughan JC Science advances 39661691 Sci Adv 2024 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/39661691
Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate toward the adult podocyte fate. Kaverina NV, Eng DG, Freedman BS, Kutz JN, Chozinski TJ, Vaughan JC, Miner JH, Pippin JW, Shankland SJ Kidney international 31200942 Kidney Int 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31200942
Extended depth-of-field light-sheet microscopy improves imaging of large volumes at high numerical aperture. Keomanee-Dizon K, Jones M, Luu P, Fraser SE, Truong TV Applied physics letters 36276589 Appl Phys Lett 2022 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/36276589
Genetic and neuronal regulation of sleep by neuropeptide VF. Lee DA, Andreev A, Truong TV, Chen A, Hill AJ, Oikonomou G, Pham U, Hong YK, Tran S, Glass L, Sapin V, Engle J, Fraser SE, Prober DA eLife 29106375 Elife 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/29106375
Regional synapse gain and loss accompany memory formation in larval zebrafish. Dempsey WP, Du Z, Nadtochiy A, Smith CD, Czajkowski K, Andreev A, Robson DN, Li JM, Applebaum S, Truong TV, Kesselman C, Fraser SE, Arnold DB Proceedings of the National Academy of Sciences of the United States of America 35031564 Proc Natl Acad Sci U S A 2022 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/35031564
A versatile, multi-laser twin-microscope system for light-sheet imaging. Keomanee-Dizon K, Fraser SE, Truong TV The Review of scientific instruments 32486724 Rev Sci Instrum 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32486724
Sharing Begins at Home: How Continuous and Ubiquitous FAIRness Can Enhance Research Productivity and Data Reuse. Dempsey W, Foster I, Fraser S, Kesselman C Harvard data science review 36035065 Harv Data Sci Rev 2022 Summer https://www.ncbi.nlm.nih.gov/pubmed/36035065
Experiences with Deriva: An Asset Management Platform for Accelerating eScience. Bugacov A, Czajkowski K, Kesselman C, Kumar A, Schuler RE, Tangmunarunkit H Proceedings ... IEEE International Conference on eScience. IEEE International Conference on eScience 29756001 Proc IEEE Int Conf Escience 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29756001
ERMrest: A Collaborative Data Catalog with Fine Grain Access Control. Czajkowski K, Kesselman C, Schuler R Proceedings ... IEEE International Conference on eScience. IEEE International Conference on eScience 29756002 Proc IEEE Int Conf Escience 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29756002
Using enhanced number and brightness to measure protein oligomerization dynamics in live cells. Cutrale F, Rodriguez D, Hortigüela V, Chiu CL, Otterstrom J, Mieruszynski S, Seriola A, Larrañaga E, Raya A, Lakadamyali M, Fraser SE, Martinez E, Ojosnegros S Nature protocols 30675035 Nat Protoc 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30675035
High-contrast, synchronous volumetric imaging with selective volume illumination microscopy. Truong TV, Holland DB, Madaan S, Andreev A, Keomanee-Dizon K, Troll JV, Koo DES, McFall-Ngai MJ, Fraser SE Communications biology 32060411 Commun Biol 2020 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/32060411
Optical imaging. Expansion microscopy. Chen F, Tillberg PW, Boyden ES Science (New York, N.Y.) 25592419 Science 2015 Jan 30 https://www.ncbi.nlm.nih.gov/pubmed/25592419
High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing. de Paz AM, Cybulski TR, Marblestone AH, Zamft BM, Church GM, Boyden ES, Kording KP, Tyo KEJ Nucleic acids research 29718339 Nucleic Acids Res 2018 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/29718339
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Piatkevich KD, Jung EE, Straub C, Linghu C, Park D, Suk HJ, Hochbaum DR, Goodwin D, Pnevmatikakis E, Pak N, Kawashima T, Yang CT, Rhoades JL, Shemesh O, Asano S, Yoon YG, Freifeld L, Saulnier JL, Riegler C, Engert F, Hughes T, Drobizhev M, Szabo B, Ahrens MB, Flavell SW, Sabatini BL, Boyden ES Nature chemical biology 29483642 Nat Chem Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29483642
Closed-Loop Real-Time Imaging Enables Fully Automated Cell-Targeted Patch-Clamp Neural Recording In Vivo. Suk HJ, van Welie I, Kodandaramaiah SB, Allen B, Forest CR, Boyden ES Neuron 28858614 Neuron 2017 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/28858614
Single-Cell CRISPR-Based Lineage Tracing in Mice. Kalhor K, Church GM Biochemistry 31730337 Biochemistry 2019 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/31730337
Expansion microscopy of C. elegans. Yu CJ, Barry NC, Wassie AT, Sinha A, Bhattacharya A, Asano S, Zhang C, Chen F, Hobert O, Goodman MB, Haspel G, Boyden ES eLife 32356725 Elife 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32356725
Model-guided mechanism discovery and parameter selection for directed evolution. Stainbrook SC, Tyo KEJ Applied microbiology and biotechnology 31686141 Appl Microbiol Biotechnol 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31686141
Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications. Zhang YS, Chang JB, Alvarez MM, Trujillo-de Santiago G, Aleman J, Batzaya B, Krishnadoss V, Ramanujam AA, Kazemzadeh-Narbat M, Chen F, Tillberg PW, Dokmeci MR, Boyden ES, Khademhosseini A Scientific reports 26975883 Sci Rep 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26975883
Engineering Ca(2+)-Dependent DNA Polymerase Activity. Biggs BW, de Paz AM, Bhan NJ, Cybulski TR, Church GM, Tyo KEJ ACS synthetic biology 37856140 ACS Synth Biol 2023 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/37856140
Post-translational digital data encoding into the genomes of mammalian cell populations. Callisto A, Strutz J, Leeper K, Kalhor R, Church G, Tyo KEJ, Bhan N bioRxiv : the preprint server for biology 38765976 bioRxiv 2024 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/38765976
Puzzle Imaging: Using Large-Scale Dimensionality Reduction Algorithms for Localization. Glaser JI, Zamft BM, Church GM, Kording KP PloS one 26192446 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/26192446
Evidence for Long-Timescale Patterns of Synaptic Inputs in CA1 of Awake Behaving Mice. Kolb I, Talei Franzesi G, Wang M, Kodandaramaiah SB, Forest CR, Boyden ES, Singer AC The Journal of neuroscience : the official journal of the Society for Neuroscience 29279309 J Neurosci 2018 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/29279309
Modern Machine Learning as a Benchmark for Fitting Neural Responses. Benjamin AS, Fernandes HL, Tomlinson T, Ramkumar P, VerSteeg C, Chowdhury RH, Miller LE, Kording KP Frontiers in computational neuroscience 30072887 Front Comput Neurosci 2018 https://www.ncbi.nlm.nih.gov/pubmed/30072887
Developmental barcoding of whole mouse via homing CRISPR. Kalhor R, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, Church GM Science (New York, N.Y.) 30093604 Science 2018 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/30093604
Rapidly evolving homing CRISPR barcodes. Kalhor R, Mali P, Church GM Nature methods 27918539 Nat Methods 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27918539
Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P Nano letters 28933153 Nano Lett 2017 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/28933153
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES Cell 28575667 Cell 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28575667
3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds. Oran D, Rodriques SG, Gao R, Asano S, Skylar-Scott MA, Chen F, Tillberg PW, Marblestone AH, Boyden ES Science (New York, N.Y.) 30545883 Science 2018 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/30545883
Advances in the automation of whole-cell patch clamp technology. Suk HJ, Boyden ES, van Welie I Journal of neuroscience methods 31336060 J Neurosci Methods 2019 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/31336060
A cryptography-based approach for movement decoding. Dyer EL, Gheshlaghi Azar M, Perich MG, Fernandes HL, Naufel S, Miller LE, Körding KP Nature biomedical engineering 31015712 Nat Biomed Eng 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/31015712
Wide-field three-photon excitation in biological samples. Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PT Light, science & applications 29152380 Light Sci Appl 2017 May 5 https://www.ncbi.nlm.nih.gov/pubmed/29152380
Inferring causal connectivity from pairwise recordings and optogenetics. Lepperød ME, Stöber T, Hafting T, Fyhn M, Kording KP PLoS computational biology 37934793 PLoS Comput Biol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37934793
Chemically Inducible Chromosomal Evolution (CIChE) for Multicopy Metabolic Pathway Engineering. Love AM, Biggs BW, Tyo KEJ, Ajikumar PK Methods in molecular biology (Clifton, N.J.) 30788784 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/30788784
Molecular recordings by directed CRISPR spacer acquisition. Shipman SL, Nivala J, Macklis JD, Church GM Science (New York, N.Y.) 27284167 Science 2016 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/27284167
Assembly and operation of the autopatcher for automated intracellular neural recording in vivo. Kodandaramaiah SB, Holst GL, Wickersham IR, Singer AC, Franzesi GT, McKinnon ML, Forest CR, Boyden ES Nature protocols 26938115 Nat Protoc 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26938115
Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain. Singer AC, Talei Franzesi G, Kodandaramaiah SB, Flores FJ, Cohen JD, Lee AK, Borgers C, Forest CR, Kopell NJ, Boyden ES Journal of neurophysiology 28566460 J Neurophysiol 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28566460
Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration. Nivala J, Shipman SL, Church GM Nature microbiology 29379209 Nat Microbiol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29379209
Expansion microscopy: enabling single cell analysis in intact biological systems. Alon S, Huynh GH, Boyden ES The FEBS journal 29938896 FEBS J 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/29938896
Engineering genetic circuit interactions within and between synthetic minimal cells. Adamala KP, Martin-Alarcon DA, Guthrie-Honea KR, Boyden ES Nature chemistry 28430194 Nat Chem 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28430194
A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve. Caravaca AS, Tsaava T, Goldman L, Silverman H, Riggott G, Chavan SS, Bouton C, Tracey KJ, Desimone R, Boyden ES, Sohal HS, Olofsson PS Journal of neural engineering 28628030 J Neural Eng 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28628030
Spatial information in large-scale neural recordings. Cybulski TR, Glaser JI, Marblestone AH, Zamft BM, Boyden ES, Church GM, Kording KP Frontiers in computational neuroscience 25653613 Front Comput Neurosci 2014 https://www.ncbi.nlm.nih.gov/pubmed/25653613
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems. Alon S, Goodwin DR, Sinha A, Wassie AT, Chen F, Daugharthy ER, Bando Y, Kajita A, Xue AG, Marrett K, Prior R, Cui Y, Payne AC, Yao CC, Suk HJ, Wang R, Yu CJ, Tillberg P, Reginato P, Pak N, Liu S, Punthambaker S, Iyer EPR, Kohman RE, Miller JA, Lein ES, Lako A, Cullen N, Rodig S, Helvie K, Abravanel DL, Wagle N, Johnson BE, Klughammer J, Slyper M, Waldman J, Jané-Valbuena J, Rozenblatt-Rosen O, Regev A, IMAXT Consortium, Church GM, Marblestone AH, Boyden ES Science (New York, N.Y.) 33509999 Science 2021 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/33509999
RNA timestamps identify the age of single molecules in RNA sequencing. Rodriques SG, Chen LM, Liu S, Zhong ED, Scherrer JR, Boyden ES, Chen F Nature biotechnology 33077959 Nat Biotechnol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33077959
Microchip amplifier for in vitro, in vivo, and automated whole cell patch-clamp recording. Harrison RR, Kolb I, Kodandaramaiah SB, Chubykin AA, Yang A, Bear MF, Boyden ES, Forest CR Journal of neurophysiology 25429119 J Neurophysiol 2015 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/25429119
Expansion Mini-Microscopy: An Enabling Alternative in Point-of-Care Diagnostics. Zhang YS, Santiago GT, Alvarez MM, Schiff SJ, Boyden ES, Khademhosseini A Current opinion in biomedical engineering 29062977 Curr Opin Biomed Eng 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/29062977
Iterative expansion microscopy. Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, Cai D, Boyden ES Nature methods 28417997 Nat Methods 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28417997
Nucleotide-time alignment for molecular recorders. Cybulski TR, Boyden ES, Church GM, Tyo KEJ, Kording KP PLoS computational biology 28459860 PLoS Comput Biol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28459860
DNA binding strength increases the processivity and activity of a Y-Family DNA polymerase. Wu J, de Paz A, Zamft BM, Marblestone AH, Boyden ES, Kording KP, Tyo KEJ Scientific reports 28684739 Sci Rep 2017 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/28684739
CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Shipman SL, Nivala J, Macklis JD, Church GM Nature 28700573 Nature 2017 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/28700573
Programmable RNA-binding protein composed of repeats of a single modular unit. Adamala KP, Martin-Alarcon DA, Boyden ES Proceedings of the National Academy of Sciences of the United States of America 27118836 Proc Natl Acad Sci U S A 2016 May 10 https://www.ncbi.nlm.nih.gov/pubmed/27118836
Nanoscale imaging of RNA with expansion microscopy. Chen F, Wassie AT, Cote AJ, Sinha A, Alon S, Asano S, Daugharthy ER, Chang JB, Marblestone A, Church GM, Raj A, Boyden ES Nature methods 27376770 Nat Methods 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27376770
Toward an Integration of Deep Learning and Neuroscience. Marblestone AH, Wayne G, Kording KP Frontiers in computational neuroscience 27683554 Front Comput Neurosci 2016 https://www.ncbi.nlm.nih.gov/pubmed/27683554
Could a Neuroscientist Understand a Microprocessor? Jonas E, Kording KP PLoS computational biology 28081141 PLoS Comput Biol 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/28081141
Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion. Younger AKD, Su PY, Shepard AJ, Udani SV, Cybulski TR, Tyo KEJ, Leonard JN Protein engineering, design & selection : PEDS 29385546 Protein Eng Des Sel 2018 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/29385546
Expansion microscopy: development and neuroscience applications. Karagiannis ED, Boyden ES Current opinion in neurobiology 29316506 Curr Opin Neurobiol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29316506
The Development and Analysis of Integrated Neuroscience Data. Glaser JI, Kording KP Frontiers in computational neuroscience 26903852 Front Comput Neurosci 2016 https://www.ncbi.nlm.nih.gov/pubmed/26903852
Relationship Between Sleep Quality and Mood: Ecological Momentary Assessment Study. Triantafillou S, Saeb S, Lattie EG, Mohr DC, Kording KP JMIR mental health 30916663 JMIR Ment Health 2019 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/30916663
On Functions Computed on Trees. Farhoodi R, Filom K, Jones IS, Kording KP Neural computation 31525312 Neural Comput 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31525312
ExCel: Super-Resolution Imaging of C. elegans with Expansion Microscopy. Yu CJ, Orozco Cosio DM, Boyden ES Methods in molecular biology (Clifton, N.J.) 35320565 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35320565
Lineage barcoding in mice with homing CRISPR. Leeper K, Kalhor K, Vernet A, Graveline A, Church GM, Mali P, Kalhor R Nature protocols 33692551 Nat Protoc 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33692551
Recording Temporal Signals with Minutes Resolution Using Enzymatic DNA Synthesis. Bhan N, Callisto A, Strutz J, Glaser J, Kalhor R, Boyden ES, Church G, Kording K, Tyo KEJ Journal of the American Chemical Society 34591459 J Am Chem Soc 2021 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/34591459
Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Guenthner CJ, Miyamichi K, Yang HH, Heller HC, Luo L Neuron 23764283 Neuron 2013 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/23764283
Optical neural interfaces. Warden MR, Cardin JA, Deisseroth K Annual review of biomedical engineering 25014785 Annu Rev Biomed Eng 2014 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/25014785
Visualizing hypothalamic network dynamics for appetitive and consummatory behaviors. Jennings JH, Ung RL, Resendez SL, Stamatakis AM, Taylor JG, Huang J, Veleta K, Kantak PA, Aita M, Shilling-Scrivo K, Ramakrishnan C, Deisseroth K, Otte S, Stuber GD Cell 25635459 Cell 2015 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/25635459
Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping. Beier KT, Steinberg EE, DeLoach KE, Xie S, Miyamichi K, Schwarz L, Gao XJ, Kremer EJ, Malenka RC, Luo L Cell 26232228 Cell 2015 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/26232228
Integration of optogenetics with complementary methodologies in systems neuroscience. Kim CK, Adhikari A, Deisseroth K Nature reviews. Neuroscience 28303019 Nat Rev Neurosci 2017 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/28303019
Targeting cells with single vectors using multiple-feature Boolean logic. Fenno LE, Mattis J, Ramakrishnan C, Hyun M, Lee SY, He M, Tucciarone J, Selimbeyoglu A, Berndt A, Grosenick L, Zalocusky KA, Bernstein H, Swanson H, Perry C, Diester I, Boyce FM, Bass CE, Neve R, Huang ZJ, Deisseroth K Nature methods 24908100 Nat Methods 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24908100
Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Lammel S, Steinberg EE, Földy C, Wall NR, Beier K, Luo L, Malenka RC Neuron 25611513 Neuron 2015 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/25611513
Prolonged, brain-wide expression of nuclear-localized GCaMP3 for functional circuit mapping. Kim CK, Miri A, Leung LC, Berndt A, Mourrain P, Tank DW, Burdine RD Frontiers in neural circuits 25505384 Front Neural Circuits 2014 https://www.ncbi.nlm.nih.gov/pubmed/25505384
Enhancing the performance of the light field microscope using wavefront coding. Cohen N, Yang S, Andalman A, Broxton M, Grosenick L, Deisseroth K, Horowitz M, Levoy M Optics express 25322056 Opt Express 2014 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/25322056
CloudReg: automatic terabyte-scale cross-modal brain volume registration. Chandrashekhar V, Tward DJ, Crowley D, Crow AK, Wright MA, Hsueh BY, Gore F, Machado TA, Branch A, Rosenblum JS, Deisseroth K, Vogelstein JT Nature methods 34253927 Nat Methods 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34253927
Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex. Wang GX, Smith SJ, Mourrain P Neuron 25521380 Neuron 2014 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/25521380
Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields. Rickgauer JP, Deisseroth K, Tank DW Nature neuroscience 25402854 Nat Neurosci 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25402854
The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC Philosophical transactions of the Royal Society of London. Series B, Biological sciences 25823863 Philos Trans R Soc Lond B Biol Sci 2015 May 19 https://www.ncbi.nlm.nih.gov/pubmed/25823863
A screen for deeply conserved non-coding GWAS SNPs uncovers a MIR-9-2 functional mutation associated to retinal vasculature defects in human. Madelaine R, Notwell JH, Skariah G, Halluin C, Chen CC, Bejerano G, Mourrain P Nucleic acids research 29518216 Nucleic Acids Res 2018 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/29518216
BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM Cancer discovery 28790031 Cancer Discov 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28790031
Ancestral Circuits for the Coordinated Modulation of Brain State. Lovett-Barron M, Andalman AS, Allen WE, Vesuna S, Kauvar I, Burns VM, Deisseroth K Cell 29103613 Cell 2017 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/29103613
Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Ye L, Allen WE, Thompson KR, Tian Q, Hsueh B, Ramakrishnan C, Wang AC, Jennings JH, Adhikari A, Halpern CH, Witten IB, Barth AL, Luo L, McNab JA, Deisseroth K Cell 27238022 Cell 2016 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/27238022
A Neural Basis for Control of Cichlid Female Reproductive Behavior by Prostaglandin F2α. Juntti SA, Hilliard AT, Kent KR, Kumar A, Nguyen A, Jimenez MA, Loveland JL, Mourrain P, Fernald RD Current biology : CB 26996507 Curr Biol 2016 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/26996507
MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis. Madelaine R, Sloan SA, Huber N, Notwell JH, Leung LC, Skariah G, Halluin C, Paşca SP, Bejerano G, Krasnow MA, Barres BA, Mourrain P Cell reports 28813666 Cell Rep 2017 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/28813666
Rabies screen reveals GPe control of cocaine-triggered plasticity. Beier KT, Kim CK, Hoerbelt P, Hung LW, Heifets BD, DeLoach KE, Mosca TJ, Neuner S, Deisseroth K, Luo L, Malenka RC Nature 28902833 Nature 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28902833
Closed-loop and activity-guided optogenetic control. Grosenick L, Marshel JH, Deisseroth K Neuron 25856490 Neuron 2015 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/25856490
Circuit dynamics of adaptive and maladaptive behaviour. Deisseroth K Nature 24429629 Nature 2014 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/24429629
Structural and molecular interrogation of intact biological systems. Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K Nature 23575631 Nature 2013 May 16 https://www.ncbi.nlm.nih.gov/pubmed/23575631
Three-dimensional intact-tissue sequencing of single-cell transcriptional states. Wang X, Allen WE, Wright MA, Sylwestrak EL, Samusik N, Vesuna S, Evans K, Liu C, Ramakrishnan C, Liu J, Nolan GP, Bava FA, Deisseroth K Science (New York, N.Y.) 29930089 Science 2018 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/29930089
Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. Rei D, Mason X, Seo J, Gräff J, Rudenko A, Wang J, Rueda R, Siegert S, Cho S, Canter RG, Mungenast AE, Deisseroth K, Tsai LH Proceedings of the National Academy of Sciences of the United States of America 25995364 Proc Natl Acad Sci U S A 2015 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/25995364
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Bagot RC, Parise EM, Peña CJ, Zhang HX, Maze I, Chaudhury D, Persaud B, Cachope R, Bolaños-Guzmán CA, Cheer JF, Deisseroth K, Han MH, Nestler EJ Nature communications 25952660 Nat Commun 2015 May 8 https://www.ncbi.nlm.nih.gov/pubmed/25952660
Natural neural projection dynamics underlying social behavior. Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K Cell 24949967 Cell 2014 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/24949967
Imaging zebrafish neural circuitry from whole brain to synapse. Leung LC, Wang GX, Mourrain P Frontiers in neural circuits 23630470 Front Neural Circuits 2013 https://www.ncbi.nlm.nih.gov/pubmed/23630470
Two eARCHT3.0 Lines for Optogenetic Silencing of Dopaminergic and Serotonergic Neurons. Krol A, Lopez-Huerta VG, Corey TEC, Deisseroth K, Ting JT, Feng G Frontiers in neural circuits 30774584 Front Neural Circuits 2019 https://www.ncbi.nlm.nih.gov/pubmed/30774584
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM, Jiang Y, Wang H, Fenno LE, Tok JB, Pașca SP, Shen K, Bao Z, Deisseroth K Science (New York, N.Y.) 32193327 Science 2020 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/32193327
Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri AR, Gage FH, Chen G Stem cell research 23759711 Stem Cell Res 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23759711
Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE Nature 27487209 Nature 2016 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/27487209
Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. van den Hurk M, Kenis G, Bardy C, van den Hove DL, Gage FH, Steinbusch HW, Rutten BP Epigenomics 27419933 Epigenomics 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27419933
Early life experience drives structural variation of neural genomes in mice. Bedrosian TA, Quayle C, Novaresi N, Gage FH Science (New York, N.Y.) 29567711 Science 2018 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/29567711
Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J Cell 26365491 Cell 2015 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/26365491
Environment-driven somatic mosaicism in brain disorders. Bedrosian TA, Linker S, Gage FH Genome medicine 27215330 Genome Med 2016 May 23 https://www.ncbi.nlm.nih.gov/pubmed/27215330
Correction to Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proceedings of the National Academy of Sciences of the United States of America 40512729 Proc Natl Acad Sci U S A 2025 Jul https://www.ncbi.nlm.nih.gov/pubmed/40512729
RNA-sequencing from single nuclei. Grindberg RV, Yee-Greenbaum JL, McConnell MJ, Novotny M, O'Shaughnessy AL, Lambert GM, Araúzo-Bravo MJ, Lee J, Fishman M, Robbins GE, Lin X, Venepally P, Badger JH, Galbraith DW, Gage FH, Lasken RS Proceedings of the National Academy of Sciences of the United States of America 24248345 Proc Natl Acad Sci U S A 2013 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/24248345
Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. Johnston ST, Shtrahman M, Parylak S, Gonçalves JT, Gage FH Neurobiology of learning and memory 26549627 Neurobiol Learn Mem 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26549627
Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C Frontiers in molecular neuroscience 30147644 Front Mol Neurosci 2018 https://www.ncbi.nlm.nih.gov/pubmed/30147644
A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons. Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, Gage FH Nature communications 30082781 Nat Commun 2018 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/30082781
Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium. Stern S, Santos R, Marchetto MC, Mendes APD, Rouleau GA, Biesmans S, Wang QW, Yao J, Charnay P, Bang AG, Alda M, Gage FH Molecular psychiatry 28242870 Mol Psychiatry 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/28242870
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH eLife 30730291 Elife 2019 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/30730291
The role of adult hippocampal neurogenesis in brain health and disease. Toda T, Parylak SL, Linker SB, Gage FH Molecular psychiatry 29679070 Mol Psychiatry 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/29679070
Insights into the role of somatic mosaicism in the brain. Paquola ACM, Erwin JA, Gage FH Current opinion in systems biology 29226270 Curr Opin Syst Biol 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/29226270
Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. Bardy C, van den Hurk M, Kakaradov B, Erwin JA, Jaeger BN, Hernandez RV, Eames T, Paucar AA, Gorris M, Marchand C, Jappelli R, Barron J, Bryant AK, Kellogg M, Lasken RS, Rutten BP, Steinbusch HW, Yeo GW, Gage FH Molecular psychiatry 27698428 Mol Psychiatry 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27698428
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders. Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R Antioxidants & redox signaling 30585734 Antioxid Redox Signal 2019 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/30585734
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R Stem cell reports 26610635 Stem Cell Reports 2015 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/26610635
Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJE, Parylak SL, Paquola ACM, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH Nature communications 27090946 Nat Commun 2016 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/27090946
Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges. Kim Y, Santos R, Gage FH, Marchetto MC Frontiers in cellular neuroscience 28261061 Front Cell Neurosci 2017 https://www.ncbi.nlm.nih.gov/pubmed/28261061
Mobile DNA elements in the generation of diversity and complexity in the brain. Erwin JA, Marchetto MC, Gage FH Nature reviews. Neuroscience 25005482 Nat Rev Neurosci 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/25005482
Increasing the resolution of the adult neurogenesis picture. Lacar B, Parylak SL, Vadodaria KC, Sarkar A, Gage FH F1000prime reports 24592320 F1000Prime Rep 2014 https://www.ncbi.nlm.nih.gov/pubmed/24592320
Differential L1 regulation in pluripotent stem cells of humans and apes. Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH Nature 24153179 Nature 2013 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/24153179
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. Vadodaria KC, Mendes APD, Mei A, Racha V, Erikson G, Shokhirev MN, Oefner R, Heard KJ, McCarthy MJ, Eyler L, Kelsoe JR, Santos R, Marchetto MC, Gage FH Stem cell reports 33667413 Stem Cell Reports 2021 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/33667413
An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis. Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A Molecular psychiatry 28924182 Mol Psychiatry 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/28924182
Examining non-LTR retrotransposons in the context of the evolving primate brain. Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage FH BMC biology 28800766 BMC Biol 2017 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/28800766
L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH Nature neuroscience 27618310 Nat Neurosci 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27618310
A human neurodevelopmental model for Williams syndrome. Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR Nature 27509850 Nature 2016 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/27509850
Prediction of response to drug therapy in psychiatric disorders. Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH Open biology 29794033 Open Biol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29794033
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage FH Proceedings of the National Academy of Sciences of the United States of America 25870293 Proc Natl Acad Sci U S A 2015 May 19 https://www.ncbi.nlm.nih.gov/pubmed/25870293
In vivo imaging of dendritic pruning in dentate granule cells. Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage FH Nature neuroscience 27135217 Nat Neurosci 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27135217
Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Krishnaswami SR, Grindberg RV, Novotny M, Venepally P, Lacar B, Bhutani K, Linker SB, Pham S, Erwin JA, Miller JA, Hodge R, McCarthy JK, Kelder M, McCorrison J, Aevermann BD, Fuertes FD, Scheuermann RH, Lee J, Lein ES, Schork N, McConnell MJ, Gage FH, Lasken RS Nature protocols 26890679 Nat Protoc 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26890679
Mosaic copy number variation in human neurons. McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH Science (New York, N.Y.) 24179226 Science 2013 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/24179226
Conserved expression of transposon-derived non-coding transcripts in primate stem cells. Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage FH, Bourque G BMC genomics 28245871 BMC Genomics 2017 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/28245871
Adult Hippocampal Neurogenesis: A Coming-of-Age Story. Kuhn HG, Toda T, Gage FH The Journal of neuroscience : the official journal of the Society for Neuroscience 30381404 J Neurosci 2018 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/30381404
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH Nature neuroscience 30617258 Nat Neurosci 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30617258
To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly. Schafer ST, Gage FH Proceedings of the National Academy of Sciences of the United States of America 33883269 Proc Natl Acad Sci U S A 2021 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33883269
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. Niemsiri V, Rosenthal SB, Nievergelt CM, Maihofer AX, Marchetto MC, Santos R, Shekhtman T, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Burdick KE, Calabrese JR, Calkin CV, Conroy C, Coryell WH, DeModena A, Eyler LT, Feeder S, Fisher C, Frazier N, Frye MA, Gao K, Garnham J, Gershon ES, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband SG, Lohoff FW, McCarthy MJ, McInnis MG, Craig D, Millett CE, Mondimore F, Morken G, Nurnberger JI, Donovan CO, Øedegaard KJ, Ryan K, Schinagle M, Shilling PD, Slaney C, Stapp EK, Stautland A, Tarwater B, Zandi PP, Alda M, Fisch KM, Gage FH, Kelsoe JR Molecular psychiatry 36991131 Mol Psychiatry 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/36991131
FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Webb AE, Pollina EA, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, Sewak M, Rando TA, Guillemot F, Wernig M, Brunet A Cell reports 23891001 Cell Rep 2013 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/23891001
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Chanda S, Marro S, Wernig M, Südhof TC Proceedings of the National Academy of Sciences of the United States of America 24046374 Proc Natl Acad Sci U S A 2013 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/24046374
An indirect approach to generating specific human cell types. Lujan E, Wernig M Nature methods 23269377 Nat Methods 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23269377
Induced neuronal reprogramming. Ang CE, Wernig M The Journal of comparative neurology 24771471 J Comp Neurol 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24771471
Comprehensive qPCR profiling of gene expression in single neuronal cells. Citri A, Pang ZP, Südhof TC, Wernig M, Malenka RC Nature protocols 22193304 Nat Protoc 2011 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/22193304
Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. Davila J, Chanda S, Ang CE, Südhof TC, Wernig M Journal of neuroscience methods 23562599 J Neurosci Methods 2013 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/23562599
Generation of oligodendroglial cells by direct lineage conversion. Yang N, Zuchero JB, Ahlenius H, Marro S, Ng YH, Vierbuchen T, Hawkins JS, Geissler R, Barres BA, Wernig M Nature biotechnology 23584610 Nat Biotechnol 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23584610
Cerebellins are differentially expressed in selective subsets of neurons throughout the brain. Seigneur E, Südhof TC The Journal of comparative neurology 28714144 J Comp Neurol 2017 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/28714144
Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents. Maxeiner S, Benseler F, Krasteva-Christ G, Brose N, Südhof TC Molecular biology and evolution 32011705 Mol Biol Evol 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32011705
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Südhof TC Cell 31585084 Cell 2019 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/31585084
Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics. Ng YH, Chanda S, Janas JA, Yang N, Kokubu Y, Südhof TC, Wernig M Stem cell reports 34171286 Stem Cell Reports 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/34171286
Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses. Han Y, Cao R, Qin L, Chen LY, Tang AH, Südhof TC, Zhang B Science advances 35704570 Sci Adv 2022 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/35704570
The cell biology of synapse formation. Südhof TC The Journal of cell biology 34086051 J Cell Biol 2021 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/34086051
Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity. Golf SR, Trotter JH, Wang J, Nakahara G, Han X, Wernig M, Südhof TC bioRxiv : the preprint server for biology 37090508 bioRxiv 2025 May 6 https://www.ncbi.nlm.nih.gov/pubmed/37090508
Molecular self-avoidance in synaptic neurexin complexes. Wang CY, Trotter JH, Liakath-Ali K, Lee SJ, Liu X, Südhof TC Science advances 34919427 Sci Adv 2021 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/34919427
Defined human tri-lineage brain microtissues. Uenaka T, Jung S, Kumar I, Vodehnal K, Rastogi M, Yoo Y, Koontz M, Thome C, Li W, Chan T, Green EM, Chesnov K, Sun Z, Zhang S, Wang J, Venida A, Mellier AM, Atkins M, Jackrel M, Skotheim JM, Wyss-Coray T, Abu-Remaileh M, Lashuel HA, Bassik MC, Südhof TC, Del Sol A, Ullian E, Wernig M bioRxiv : the preprint server for biology 40799568 bioRxiv 2025 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/40799568
Distinct mechanisms control the specific synaptic functions of Neuroligin 1 and Neuroligin 2. Wang J, Sudhof T, Wernig M EMBO reports 39747663 EMBO Rep 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39747663
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Lujan E, Chanda S, Ahlenius H, Südhof TC, Wernig M Proceedings of the National Academy of Sciences of the United States of America 22308465 Proc Natl Acad Sci U S A 2012 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/22308465
Induced neuronal cells: how to make and define a neuron. Yang N, Ng YH, Pang ZP, Südhof TC, Wernig M Cell stem cell 22136927 Cell Stem Cell 2011 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/22136927
Cellular reprogramming: recent advances in modeling neurological diseases. Ming GL, Brüstle O, Muotri A, Studer L, Wernig M, Christian KM The Journal of neuroscience : the official journal of the Society for Neuroscience 22072658 J Neurosci 2011 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/22072658
Generation of induced neuronal cells by the single reprogramming factor ASCL1. Chanda S, Ang CE, Davila J, Pak C, Mall M, Lee QY, Ahlenius H, Jung SW, Südhof TC, Wernig M Stem cell reports 25254342 Stem Cell Reports 2014 Aug 12 https://www.ncbi.nlm.nih.gov/pubmed/25254342
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC The Journal of experimental medicine 27001749 J Exp Med 2016 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/27001749
Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules. Jiang X, Sando R, Südhof TC Proceedings of the National Academy of Sciences of the United States of America 33431662 Proc Natl Acad Sci U S A 2021 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/33431662
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons. Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, Kalani MYS, Südhof TC, Wernig M Neuron 31257103 Neuron 2019 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/31257103
Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number. Qin L, Liu Z, Guo S, Han Y, Wang X, Ren W, Chen J, Zhen H, Nie C, Xing KK, Chen T, Südhof TC, Sun Y, Zhang B Molecular psychiatry 39003414 Mol Psychiatry 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39003414
The many roads to Rome: induction of neural precursor cells from fibroblasts. Lujan E, Wernig M Current opinion in genetics & development 22868177 Curr Opin Genet Dev 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22868177
Retinoic Acid Receptor RARα-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex. Zhong LR, Chen X, Park E, Südhof TC, Chen L The Journal of neuroscience : the official journal of the Society for Neuroscience 30355624 J Neurosci 2018 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/30355624
Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Pak C, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, Südhof TC Cell stem cell 26279266 Cell Stem Cell 2015 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/26279266
Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Yi F, Danko T, Botelho SC, Patzke C, Pak C, Wernig M, Südhof TC Science (New York, N.Y.) 26966193 Science 2016 May 6 https://www.ncbi.nlm.nih.gov/pubmed/26966193
Transdifferentiation of human adult peripheral blood T cells into neurons. Tanabe K, Ang CE, Chanda S, Olmos VH, Haag D, Levinson DF, Südhof TC, Wernig M Proceedings of the National Academy of Sciences of the United States of America 29866841 Proc Natl Acad Sci U S A 2018 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/29866841
Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity. Chanda S, Ang CE, Lee QY, Ghebrial M, Haag D, Shibuya Y, Wernig M, Südhof TC Cell stem cell 31155484 Cell Stem Cell 2019 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/31155484
Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates. Mall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Euong Ang C, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, Jolma A, Steinmetz LM, Taipale J, Südhof TC, Wernig M Nature 28379941 Nature 2017 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/28379941
Generation of pure GABAergic neurons by transcription factor programming. Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, Wernig M Nature methods 28504679 Nat Methods 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28504679
Insights and applications of direct neuronal reprogramming. Schaukowitch K, Janas JA, Wernig M Current opinion in genetics & development 37862835 Curr Opin Genet Dev 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37862835
Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism. Wang L, Mirabella VR, Dai R, Su X, Xu R, Jadali A, Bernabucci M, Singh I, Chen Y, Tian J, Jiang P, Kwan KY, Pak C, Liu C, Comoletti D, Hart RP, Chen C, Südhof TC, Pang ZP Molecular psychiatry 36280753 Mol Psychiatry 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/36280753
Induction of human neuronal cells by defined transcription factors. Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M Nature 21617644 Nature 2011 May 26 https://www.ncbi.nlm.nih.gov/pubmed/21617644
Molecular roadblocks for cellular reprogramming. Vierbuchen T, Wernig M Molecular cell 23020854 Mol Cell 2012 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/23020854
Direct lineage conversions: unnatural but useful? Vierbuchen T, Wernig M Nature biotechnology 21997635 Nat Biotechnol 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21997635
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Marro S, Pang ZP, Yang N, Tsai MC, Qu K, Chang HY, Südhof TC, Wernig M Cell stem cell 21962918 Cell Stem Cell 2011 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/21962918
Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties. Chanda S, Hale WD, Zhang B, Wernig M, Südhof TC The Journal of neuroscience : the official journal of the Society for Neuroscience 28607166 J Neurosci 2017 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/28607166
Analysis of conditional heterozygous STXBP1 mutations in human neurons. Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, Südhof TC The Journal of clinical investigation 26280581 J Clin Invest 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26280581
FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig M Proceedings of the National Academy of Sciences of the United States of America 27402759 Proc Natl Acad Sci U S A 2016 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/27402759
The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling. Zhang Z, Marro SG, Zhang Y, Arendt KL, Patzke C, Zhou B, Fair T, Yang N, Südhof TC, Wernig M, Chen L Science translational medicine 30068571 Sci Transl Med 2018 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/30068571
Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses. Zhang B, Gokce O, Hale WD, Brose N, Südhof TC The Journal of experimental medicine 29724786 J Exp Med 2018 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/29724786
Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Chanda S, Aoto J, Lee SJ, Wernig M, Südhof TC Molecular psychiatry 25778475 Mol Psychiatry 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/25778475
Rapid single-step induction of functional neurons from human pluripotent stem cells. Zhang Y, Pak C, Han Y, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C, Acuna C, Covy J, Xu W, Yang N, Danko T, Chen L, Wernig M, Südhof TC Neuron 23764284 Neuron 2013 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/23764284
In Vivo Reprogramming for Brain and Spinal Cord Repair. Chen G, Wernig M, Berninger B, Nakafuku M, Parmar M, Zhang CL eNeuro 26730402 eNeuro 2015 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/26730402
Towards an Understanding of Synapse Formation. Südhof TC Neuron 30359597 Neuron 2018 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/30359597
Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways. Wu X, Morishita WK, Riley AM, Hale WD, Südhof TC, Malenka RC Neuron 30871858 Neuron 2019 May 8 https://www.ncbi.nlm.nih.gov/pubmed/30871858
Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. Gan KJ, Südhof TC Proceedings of the National Academy of Sciences of the United States of America 31160442 Proc Natl Acad Sci U S A 2019 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/31160442
Induction of synapse formation by de novo neurotransmitter synthesis. Burlingham SR, Wong NF, Peterkin L, Lubow L, Dos Santos Passos C, Benner O, Ghebrial M, Cast TP, Xu-Friedman MA, Südhof TC, Chanda S Nature communications 35650274 Nat Commun 2022 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/35650274
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins. Gan KJ, Südhof TC The Journal of neuroscience : the official journal of the Society for Neuroscience 32973045 J Neurosci 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/32973045
Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression. Liu Y, Wang J, Südhof TC, Wernig M Nature protocols 37596357 Nat Protoc 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37596357
High-Throughput Method of Whole-Brain Sectioning, Using the Tape-Transfer Technique. Pinskiy V, Jones J, Tolpygo AS, Franciotti N, Weber K, Mitra PP PloS one 26181725 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/26181725
Out-of-focus brain image detection in serial tissue sections. Pollatou A, Ferrante DD Journal of neuroscience methods 32771371 J Neurosci Methods 2020 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/32771371
Computational methods and challenges for large-scale circuit mapping. Helmstaedter M, Mitra PP Current opinion in neurobiology 22221862 Curr Opin Neurobiol 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22221862
A low-cost technique to cryo-protect and freeze rodent brains, precisely aligned to stereotaxic coordinates for whole-brain cryosectioning. Pinskiy V, Tolpygo AS, Jones J, Weber K, Franciotti N, Mitra PP Journal of neuroscience methods 23541995 J Neurosci Methods 2013 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/23541995
Towards a comprehensive atlas of cortical connections in a primate brain: Mapping tracer injection studies of the common marmoset into a reference digital template. Majka P, Chaplin TA, Yu HH, Tolpygo A, Mitra PP, Wójcik DK, Rosa MG The Journal of comparative neurology 27099164 J Comp Neurol 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/27099164
The circuit architecture of whole brains at the mesoscopic scale. Mitra PP Neuron 25233311 Neuron 2014 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/25233311
Frequency-selective control of cortical and subcortical networks by central thalamus. Liu J, Lee HJ, Weitz AJ, Fang Z, Lin P, Choy M, Fisher R, Pinskiy V, Tolpygo A, Mitra P, Schiff N, Lee JH eLife 26652162 Elife 2015 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/26652162
Discovery of a proneurogenic, neuroprotective chemical. Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL Cell 20603013 Cell 2010 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/20603013
Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. Blaya MO, Bramlett HM, Naidoo J, Pieper AA, Dietrich WD Journal of neurotrauma 24070637 J Neurotrauma 2014 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24070637
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties. Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM Journal of medicinal chemistry 24697290 J Med Chem 2014 May 8 https://www.ncbi.nlm.nih.gov/pubmed/24697290
P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Yin TC, Britt JK, De Jesús-Cortés H, Lu Y, Genova RM, Khan MZ, Voorhees JR, Shao J, Katzman AC, Huntington PJ, Wassink C, McDaniel L, Newell EA, Dutca LM, Naidoo J, Cui H, Bassuk AG, Harper MM, McKnight SL, Ready JM, Pieper AA Cell reports 25220467 Cell Rep 2014 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/25220467
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA Proceedings of the National Academy of Sciences of the United States of America 23027932 Proc Natl Acad Sci U S A 2012 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/23027932
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM Molecular psychiatry 24751964 Mol Psychiatry 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/24751964
Development of proneurogenic, neuroprotective small molecules. MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM Journal of the American Chemical Society 21210688 J Am Chem Soc 2011 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/21210688
Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder. Smiley JF, Hackett TA, Bleiwas C, Petkova E, Stankov A, Mann JJ, Rosoklija G, Dwork AJ Journal of chemical neuroanatomy 26686292 J Chem Neuroanat 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/26686292
Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury. Kemp SWP, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH Neuroscience 25313000 Neuroscience 2015 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/25313000
NPAS1 represses the generation of specific subtypes of cortical interneurons. Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, Hunt RF, Lindtner S, Erdman CA, Pieper AA, Hamilton SP, Xu D, Baraban SC, Rubenstein JL Neuron 25467980 Neuron 2014 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/25467980
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA Proceedings of the National Academy of Sciences of the United States of America 23027934 Proc Natl Acad Sci U S A 2012 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/23027934
P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases. Pieper AA, McKnight SL, Ready JM Chemical Society reviews 24514864 Chem Soc Rev 2014 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/24514864
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL Cell 25215490 Cell 2014 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/25215490
Applying a Gene Reversal Rate Computational Methodology to Identify Drugs for a Rare Cancer: Inflammatory Breast Cancer. Ji X, Williams KP, Zheng W Cancer informatics 37846218 Cancer Inform 2023 https://www.ncbi.nlm.nih.gov/pubmed/37846218
Geospatial Associations between Female Breast Cancer Mortality Rates and Environmental Socioeconomic Indicators for North Carolina. Burwell A, Kimbro S, Mulrooney T International journal of environmental research and public health 37510605 Int J Environ Res Public Health 2023 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/37510605
The G-Protein-Coupled Estrogen Receptor Selective Agonist G-1 Attenuates Cell Viability and Migration in High-Grade Serous Ovarian Cancer Cell Lines. Hanafi D, Onyenwoke RU, Kimbro KS International journal of molecular sciences 38928205 Int J Mol Sci 2024 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/38928205
Identification of Novel GANT61 Analogs with Activity in Hedgehog Functional Assays and GLI1-Dependent Cancer Cells. Abu Rabe D, Chdid L, Lamson DR, Laudeman CP, Tarpley M, Elsayed N, Smith GR, Zheng W, Dixon MS, Williams KP Molecules (Basel, Switzerland) 38999049 Molecules 2024 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/38999049
Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays. Lamson DR, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, Hughes M, Smith GR, Daye LR, Musso DL, Zheng W, Williams KP Biochimica et biophysica acta. General subjects 39151833 Biochim Biophys Acta Gen Subj 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39151833
Molecular and socioeconomic characteristics of inflammatory breast cancer in the Carolina Breast Cancer Study. Wang Q, Van Alsten SC, Ji X, Salim E, Salazar N, Scott JE, Yang X, Onyenwoke RU, Troester MA, Williams KP Breast cancer research and treatment 41569442 Breast Cancer Res Treat 2026 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/41569442
Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease. Yeyeodu S, Hanafi D, Webb K, Laurie NA, Kimbro KS Frontiers in endocrinology 38577257 Front Endocrinol (Lausanne) 2023 https://www.ncbi.nlm.nih.gov/pubmed/38577257
From in silico prediction to experimental validation: Identification of drugs and novel synergistic combinations that inhibit growth of inflammatory breast cancer cells. Salim EA, Ji X, Tarpley M, Dixon MS, Zheng W, Scott JE, Williams KP bioRxiv : the preprint server for biology 41427337 bioRxiv 2025 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/41427337
Interventions Across the Translational Research Spectrum: Addressing Disparities Among Racial and Ethnic Minoritized Youth with Type 1 Diabetes. Ellis DA, Naar S Endocrinology and metabolism clinics of North America 37865475 Endocrinol Metab Clin North Am 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37865475
Study protocol for transforming health equity research in integrated primary care: Antiracism as a disruptive innovation. Naar S, Pettus C, Anderson N, Pooler-Burgess M, Ralston P, Flynn H, Combs T, Baquet C, Schatschneider C, Luke D PloS one 38935743 PLoS One 2024 https://www.ncbi.nlm.nih.gov/pubmed/38935743
An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients. Nair V, Jandovitz N, Hirsch JS, Abate M, Satapathy SK, Roth N, Miyara SJ, Guevara S, Kressel AM, Xiang A, Wu G, Butensky SD, Lin D, Williams S, Bhaskaran MC, Majure DT, Grodstein E, Lau L, Nair G, Fahmy AE, Winnick A, Breslin N, Berlinrut I, Molmenti C, Becker LB, Malhotra P, Gautam-Goyal P, Lima B, Maybaum S, Shah SK, Takegawa R, Hayashida K, Shinozaki K, Teperman LW, Molmenti EP, Northwell Health COVID-19 Research Consortium American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 33443778 Am J Transplant 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33443778
Usefulness of Elevated Troponin to Predict Death in Patients With COVID-19 and Myocardial Injury. Majure DT, Gruberg L, Saba SG, Kvasnovsky C, Hirsch JS, Jauhar R, Northwell Health COVID-19 Research Consortium The American journal of cardiology 33058800 Am J Cardiol 2021 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/33058800
Clinical Mortality in a Large COVID-19 Cohort: Observational Study. Jarrett M, Schultz S, Lyall J, Wang J, Stier L, De Geronimo M, Nelson K Journal of medical Internet research 32930099 J Med Internet Res 2020 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/32930099
A Machine Learning Prediction Model of Respiratory Failure Within 48 Hours of Patient Admission for COVID-19: Model Development and Validation. Bolourani S, Brenner M, Wang P, McGinn T, Hirsch JS, Barnaby D, Zanos TP, Northwell COVID-19 Research Consortium Journal of medical Internet research 33476281 J Med Internet Res 2021 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/33476281
Estimating the predictive value of negative severe acute respiratory coronavirus virus 2 (SARS-CoV-2) results: A prospective study. Hirschwerk D, Foley M, Lesser M, Farber B, Crawford JM, Davidson KW, Berry GJ, Smith E, Kast C, Volel V, McGinn T Infection control and hospital epidemiology 33298203 Infect Control Hosp Epidemiol 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/33298203
Effectiveness of interventions targeting self-regulation to improve adherence to chronic disease medications: a meta-review of meta-analyses. Wilson TE, Hennessy EA, Falzon L, Boyd R, Kronish IM, Birk JL Health psychology review 31856664 Health Psychol Rev 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31856664
Clinical Usefulness of Bright White Light Therapy for Depressive Symptoms in Cancer Survivors: Results from a Series of Personalized (N-of-1) Trials. Kronish IM, Cheung YK, Julian J, Parsons F, Lee J, Yoon S, Valdimarsdottir H, Green P, Suls J, Hershman DL, Davidson KW Healthcare (Basel, Switzerland) 31905890 Healthcare (Basel) 2019 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/31905890
COVID-19 in kidney transplant recipients. Nair V, Jandovitz N, Hirsch JS, Nair G, Abate M, Bhaskaran M, Grodstein E, Berlinrut I, Hirschwerk D, Cohen SL, Davidson KW, Dominello AJ, Osorio GA, Richardson S, Teperman LW, Molmenti EP American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 32351040 Am J Transplant 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32351040
Characteristics, Cardiac Involvement, and Outcomes of Multisystem Inflammatory Syndrome of Childhood Associated with severe acute respiratory syndrome coronavirus 2 Infection. Capone CA, Subramony A, Sweberg T, Schneider J, Shah S, Rubin L, Schleien C, Northwell Health COVID-19 Research Consortium, Epstein S, Johnson JC, Kessel A, Misra N, Mitchell E, Palumbo N, Rajan S, Rocker J, Williamson K, Davidson KW The Journal of pediatrics 32553873 J Pediatr 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32553873
Significance of Multiple Adverse Social Determinants of Health on the Diagnosis, Control, and Management of Diabetes. Kim EJ, Abrahams S, Marrast L, Martinez J, Hanchate AD, Conigliaro J Journal of general internal medicine 32495092 J Gen Intern Med 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/32495092
In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study. Richardson S, Gitlin J, Kozel Z, Levy S, Rahman H, Hirsch JS, McGinn T, Diefenbach MA Open forum infectious diseases 34183983 Open Forum Infect Dis 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34183983
Expanding Knowledge and Changing Attitudes About Poverty: An Interactive, Interprofessional Approach. Marrast LM, Chim C, Tocco J, Coletti DJ, Nouryan C, Block L, Martinez J Journal of primary care & community health 35225052 J Prim Care Community Health 2022 Jan-Dec https://www.ncbi.nlm.nih.gov/pubmed/35225052
Risk factors and outcomes for acute-on-chronic liver failure in COVID-19: a large multi-center observational cohort study. Satapathy SK, Roth NC, Kvasnovsky C, Hirsch JS, Trindade AJ, Molmenti E, Barish M, Hirschwerk D, Da BL, Bernstein D, Northwell Health COVID-19 Research Consortium Hepatology international 33826042 Hepatol Int 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33826042
Effectiveness of SARS-CoV-2 Decontamination and Containment in a COVID-19 ICU. Brune Z, Kuschner CE, Mootz J, Davidson KW, Pena RCF, Ghanem MH, Fischer A, Gitman M, Teperman L, Mason C, Becker LB International journal of environmental research and public health 33802332 Int J Environ Res Public Health 2021 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/33802332
Randomized Personalized Trial for Stress Management Compared to Standard of Care. Goodwin AM, Chandereng T, Ahn H, Miller D, Slotnick S, Perrin A, Cheung YK, Davidson KW, Butler MJ Journal of personalized medicine 41590516 J Pers Med 2026 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/41590516
Protocol for randomized personalized trial for stress management compared to standard of care. Goodwin AM, Miller D, D'Angelo S, Perrin A, Wiener R, Greene B, Romain AN, Arader L, Chandereng T, Kuen Cheung Y, Davidson KW, Butler M Frontiers in psychology 37794909 Front Psychol 2023 https://www.ncbi.nlm.nih.gov/pubmed/37794909
Why Do I Get Side Effects? Personalized (N-of-1) Trials for Statin Intolerance and the Nocebo Effect. Howard JP, Wood FA, Francis DP Harvard data science review 38344133 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38344133
A Series of Remote Melatonin Supplement Interventions for Poor Sleep: Protocol for a Feasibility Pilot Study for a Series of Personalized (N-of-1) Trials. Butler M, D'Angelo S, Perrin A, Rodillas J, Miller D, Arader L, Chandereng T, Cheung YK, Shechter A, Davidson KW JMIR research protocols 37535419 JMIR Res Protoc 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37535419
Envisioning a future for precision health psychology: innovative applied statistical approaches to N-of-1 studies. Davidson KW, Cheung YK Health psychology review 28651455 Health Psychol Rev 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28651455
Patient preferences for personalized (N-of-1) trials: a conjoint analysis. Moise N, Wood D, Cheung YKK, Duan N, Onge TS, Duer-Hefele J, Pu T, Davidson KW, Kronish IM, Members of the “Personalized Trial Collaboratory” Journal of clinical epidemiology 29859242 J Clin Epidemiol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29859242
Are Nomothetic or Ideographic Approaches Superior in Predicting Daily Exercise Behaviors? Cheung YK, Hsueh PS, Qian M, Yoon S, Meli L, Diaz KM, Schwartz JE, Kronish IM, Davidson KW Methods of information in medicine 29582914 Methods Inf Med 2017 https://www.ncbi.nlm.nih.gov/pubmed/29582914
Using Behavioral Analytics to Increase Exercise: A Randomized N-of-1 Study. Yoon S, Schwartz JE, Burg MM, Kronish IM, Alcantara C, Julian J, Parsons F, Davidson KW, Diaz KM American journal of preventive medicine 29429607 Am J Prev Med 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29429607
BMI as a Risk Factor for Clinical Outcomes in Patients Hospitalized with COVID-19 in New York. Kim TS, Roslin M, Wang JJ, Kane J, Hirsch JS, Kim EJ, Northwell Health COVID-19 Research Consortium Obesity (Silver Spring, Md.) 33128848 Obesity (Silver Spring) 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33128848
Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop. Taylor HA, Finkel T, Gao Y, Ballinger SW, Campo R, Chen R, Chen SH, Davidson K, Iruela-Arispe ML, Jaquish C, LeBrasseur NK, Odden MC, Papanicolaou GJ, Picard M, Srinivas P, Tjurmina O, Wolz M, Galis ZS FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36322029 FASEB J 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36322029
Early Experience of COVID-19 in a US Children's Hospital. Kainth MK, Goenka PK, Williamson KA, Fishbein JS, Subramony A, Barone S, Belfer JA, Feld LM, Krief WI, Palumbo N, Rajan S, Rocker J, Scotto T, Sharma S, Sokoloff WC, Schleien C, Rubin LG, NORTHWELL HEALTH COVID-19 RESEARCH CONSORTIUM Pediatrics 32680880 Pediatrics 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32680880
Intersectional Identity and Racial Inequality During the COVID-19 Pandemic: Perspectives of Black Physician Mothers. Louisias M, Marrast L Journal of women's health (2002) 32762601 J Womens Health (Larchmt) 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32762601
Rapid Emergence of SARS-CoV-2 in the Greater New York Metropolitan Area: Geolocation, Demographics, Positivity Rates, and Hospitalization for 46 793 Persons Tested by Northwell Health. Reichberg SB, Mitra PP, Haghamad A, Ramrattan G, Crawford JM, Northwell COVID-19 Research Consortium, Berry GJ, Davidson KW, Drach A, Duong S, Juretschko S, Maria NI, Yang Y, Ziemba YC Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 32640030 Clin Infect Dis 2020 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/32640030
Machine learning to assist clinical decision-making during the COVID-19 pandemic. Debnath S, Barnaby DP, Coppa K, Makhnevich A, Kim EJ, Chatterjee S, Tóth V, Levy TJ, Paradis MD, Cohen SL, Hirsch JS, Zanos TP, Northwell COVID-19 Research Consortium Bioelectronic medicine 32665967 Bioelectron Med 2020 https://www.ncbi.nlm.nih.gov/pubmed/32665967
Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities. Davidson KW, Alcántara C, Miller GE The American psychologist 30394780 Am Psychol 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30394780
Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19. Nishikimi M, Rasul R, Sison CP, Jafari D, Shoaib M, Shinozaki K, Li T, Hayashida K, Rolston DM, Hirsch JS, Becker LB, Northwell Health COVID-19 Research Consortium Scientific reports 34702896 Sci Rep 2021 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/34702896
Now is the time to assess the effects of open science practiceswith randomized control trials. Suls J, Rothman AJ, Davidson KW The American psychologist 34807632 Am Psychol 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/34807632
A look at the increasing demographic representation within behavioral medicine. Yoon S, Falzon L, Anderson NB, Davidson KW Journal of behavioral medicine 30825089 J Behav Med 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30825089
Racial and ethnic minority patient participation in N-of-1 trials: perspectives of healthcare providers and patients. Marrast L, Conigliaro J, Chan C, Kim EJ, Duer-Hefele J, Diefenbach MA, Davidson KW Personalized medicine 34047197 Per Med 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34047197
Prevalence and Predictors of Venous Thromboembolism or Mortality in Hospitalized COVID-19 Patients. Cohen SL, Gianos E, Barish MA, Chatterjee S, Kohn N, Lesser M, Giannis D, Coppa K, Hirsch JS, McGinn TG, Goldin ME, Spyropoulos AC, Northwell Health COVID-19 Research Consortium Thrombosis and haemostasis 33472255 Thromb Haemost 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33472255
Examination of patient characteristics and hydroxychloroquine use based on the US Food and Drug Administration's recommendation: a cross-sectional analysis in New York. Kim EJ, Coppa K, Hirsch JS, Abrahams S, Johnson J, Lesser M, Davidson KW, Conigliaro J, Northwell Health COVID-19 Research Consortium, Northwell Health COVID-19 Research Consortium BMJ open 33558355 BMJ Open 2021 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/33558355
An R Shiny App for a Chronic Lower Back Pain Study, Personalized N-of-1 Trial. Chandereng T Harvard data science review 37091071 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/37091071
The Family of Single-Case Experimental Designs. Epstein LH, Dallery J Harvard data science review 36926648 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/36926648
Increasing the Precision of Hypertension Treatment Through Personalized Trials: a Pilot Study. Kronish IM, Cheung YK, Shimbo D, Julian J, Gallagher B, Parsons F, Davidson KW Journal of general internal medicine 30859504 J Gen Intern Med 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30859504
Using Metabolic Testing to Personalize Behavioral Obesity Treatment. Epstein LH, Apolzan JW, Moore M, Neuwald NV, Faith MS Obesity science & practice 40070464 Obes Sci Pract 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/40070464
N-of-1 Randomized Intervention Trials in Health Psychology: A Systematic Review and Methodology Critique. Shaffer JA, Kronish IM, Falzon L, Cheung YK, Davidson KW Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 30124759 Ann Behav Med 2018 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/30124759
Personalized (N-of-1) Trials for Depression: A Systematic Review. Kronish IM, Hampsey M, Falzon L, Konrad B, Davidson KW Journal of clinical psychopharmacology 29596148 J Clin Psychopharmacol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29596148
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, the Northwell COVID-19 Research Consortium, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J, Coppa K, Diefenbach MA, Dominello AJ, Duer-Hefele J, Falzon L, Gitlin J, Hajizadeh N, Harvin TG, Hirschwerk DA, Kim EJ, Kozel ZM, Marrast LM, Mogavero JN, Osorio GA, Qiu M, Zanos TP JAMA 32320003 JAMA 2020 May 26 https://www.ncbi.nlm.nih.gov/pubmed/32320003
N-of-1 Trials, Their Reporting Guidelines, and the Advancement of Open Science Principles. Porcino A, Vohra S Harvard data science review 38031562 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38031562
A Series of Virtual Interventions for Chronic Lower Back Pain: A Feasibility Pilot Study for a Series of Personalized (N-of-1) Trials. Butler M, D'Angelo S, Kaplan M, Tashnim Z, Miller D, Ahn H, Falzon L, Dominello AJ, Foroughi C, Chandereng T, Cheung K, Davidson K Harvard data science review 37609556 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/37609556
Let Sleeping Patients Lie, avoiding unnecessary overnight vitals monitoring using a clinically based deep-learning model. Tóth V, Meytlis M, Barnaby DP, Bock KR, Oppenheim MI, Al-Abed Y, McGinn T, Davidson KW, Becker LB, Hirsch JS, Zanos TP NPJ digital medicine 33299116 NPJ Digit Med 2020 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/33299116
Sex-Based Differences in COVID-19 Outcomes. Tejpal A, Gianos E, Cerise J, Hirsch JS, Rosen S, Kohn N, Lesser M, Weinberg C, Majure D, Satapathy SK, Bernstein D, Barish MA, Spyropoulos AC, Brown RM Journal of women's health (2002) 33885345 J Womens Health (Larchmt) 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33885345
Experimental Designs to Optimize Treatments for Individuals: Personalized N-of-1 Trials. Davidson KW, Silverstein M, Cheung K, Paluch RA, Epstein LH JAMA pediatrics 33587109 JAMA Pediatr 2021 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/33587109
Single case designs for early phase behavioral translational research in health psychology. Epstein LH, Bickel WK, Czajkowski SM, Paluch RA, Moeyaert M, Davidson KW Health psychology : official journal of the Division of Health Psychology, American Psychological Association 34370494 Health Psychol 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34370494
Barriers to and Facilitators for Acceptance of Comprehensive Clinical Decision Support System-Driven Care Maps for Patients With Thoracic Trauma: Interview Study Among Health Care Providers and Nurses. Jones EK, Banks A, Melton GB, Porta CM, Tignanelli CJ JMIR human factors 35293873 JMIR Hum Factors 2022 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/35293873
Mortality of Mechanically Ventilated COVID-19 Patients in Traditional versus Expanded Intensive Care Units in New York. Nishikimi M, Jafari D, Singh N, Shinozaki K, Sison CP, Shoaib M, Gong J, Rasul R, Li T, Hayashida K, Rolston DM, Miyara SJ, Hirsch JS, Gandomi A, White MT, Jarrett MP, Lesser ML, Becker LB, Northwell Health COVID-19 Research Consortium Annals of the American Thoracic Society 35213292 Ann Am Thorac Soc 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35213292
Accomplishing breakthroughs in behavioural medicine research. Davidson KW, Bacon SL, Bennett GG, Brondolo E, Czajkowski SM, Diefenbach MA, Epel ES, Matthews K, Revenson TA, Ruiz JM, Segerstrom SC, Behavioral Medicine Research Council Nature human behaviour 34127817 Nat Hum Behav 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34127817
Association of race/ethnicity with mortality in patients hospitalized with COVID-19. Richardson S, Martinez J, Hirsch JS, Cerise J, Lesser M, Roswell RO, Davidson KW, Northwell Health COVID-19 Research Consortium PloS one 35925973 PLoS One 2022 https://www.ncbi.nlm.nih.gov/pubmed/35925973
Impact of Timing of Tocilizumab Use in Hospitalized Patients With SARS-CoV-2 Infection. Singh AK, Oks M, Husk G, Dechario SP, Mina B, Singh K, Kirschenbaum L, Carpati CM, Mahmoud O, Gabra NI, Ishikawa O, Altschultz E, Shah V, Mahajan A, Gautam A, Birnbaum B, Antonacci AC, Raoof S Respiratory care 34548407 Respir Care 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34548407
A Series of Personalized Virtual Light Therapy Interventions for Fatigue: Feasibility Randomized Crossover Trial for N-of-1 Treatment. Butler M, D'Angelo S, Ahn H, Chandereng T, Miller D, Perrin A, Romain AN, Scatoni A, Friel CP, Cheung YK, Davidson KW JMIR formative research 37721795 JMIR Form Res 2023 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/37721795
Series of virtual light therapy interventions for fatigue: a feasibility pilot study protocol for a series of personalised (N-of-1) trials. Butler M, D'Angelo S, Lewis C, Miller D, Perrin A, Suls J, Chandereng T, Cheung YK, Davidson KW BMJ open 36283748 BMJ Open 2022 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/36283748
Evaluating Personalized (N-of-1) Trials in Rare Diseases: How Much Experimentation Is Enough? Cheung K, Mitsumoto H Harvard data science review 38283317 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38283317
Barriers to the Use of Clinical Decision Support for the Evaluation of Pulmonary Embolism: Qualitative Interview Study. Richardson S, Dauber-Decker KL, McGinn T, Barnaby DP, Cattamanchi A, Pekmezaris R JMIR human factors 34346901 JMIR Hum Factors 2021 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/34346901
Prevalence of SARS-CoV-2 Antibodies in Health Care Personnel in the New York City Area. Moscola J, Sembajwe G, Jarrett M, Farber B, Chang T, McGinn T, Davidson KW, Northwell Health COVID-19 Research Consortium JAMA 32780804 JAMA 2020 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/32780804
Patients and primary care providers identify opportunities for personalized (N-of-1) trials in the mobile health era. Kronish IM, Alcántara C, Duer-Hefele J, St Onge T, Davidson KW, Carter EJ, Medina V, Cohn E, Moise N Journal of clinical epidemiology 28648833 J Clin Epidemiol 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28648833
Accommodating Serial Correlation and Sequential Design Elements in Personalized Studies and Aggregated Personalized Studies. Schork NJ Harvard data science review 37032736 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/37032736
Conduct and Implementation of Personalized Trials in Research and Practice. Kravitz RL, Duan N Harvard data science review 38009129 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38009129
Introducing Data Sciences to N-of-1 Designs, Statistics, Use-Cases, the Future, and the Moniker 'N-of-1' Trial. Davidson KW, Cheung YK, Friel CP, Suls J Harvard data science review 38009132 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38009132
Personalized Data Science and Personalized (N-of-1) Trials: Promising Paradigms for Individualized Health Care. Duan N, Norman D, Schmid C, Sim I, Kravitz RL Harvard data science review 38009133 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38009133
Personalized Trial Ethics and Institutional Review Board Submissions. Samuel JP, Wootton SH Harvard data science review 38283318 Harv Data Sci Rev 2022 https://www.ncbi.nlm.nih.gov/pubmed/38283318
Molecular dissection of the role of ACE2 in glucose homeostasis. Chhabra KH, Shoemaker R, Herath CB, Thomas MC, Filipeanu CM, Lazartigues E Physiological reviews 39918873 Physiol Rev 2025 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/39918873
Stable, neuron-specific gene expression in the mouse brain. Ahmed O, Ekumi KM, Nardi FV, Maisumu G, Moussawi K, Lazartigues ED, Liang B, Yakoub AM Journal of biological engineering 38229168 J Biol Eng 2024 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/38229168
The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection. Hazra T, Tapryal N, Chakraborty A, Rayavara K, Wakamiya M, Islam A, Pan L, Hsu J, Tat V, Maruyama J, Hosoki K, Sayed I, Alcantara J, Castillo V, Tindle C, Sarker A, Cardenas V, Sharma G, Alexander LC, Sur S, Ghosh G, Paessler S, Sahoo D, Ghosh P, Das S, Boldogh I, Tseng CT Research square 35665009 Res Sq 2022 May 27 https://www.ncbi.nlm.nih.gov/pubmed/35665009
Brain organoids: building higher-order complexity and neural circuitry models. Maisumu G, Willerth S, Nestor MW, Waldau B, Schülke S, Nardi FV, Ahmed O, Zhou Y, Durens M, Liang B, Yakoub AM Trends in biotechnology 40221251 Trends Biotechnol 2025 Jul https://www.ncbi.nlm.nih.gov/pubmed/40221251
Protocol for generation of PD modeling induced neurons and detection of α-synuclein forms. Nardi FV, Maisumu G, Zhou Y, Liang B, Yakoub AM STAR protocols 39549235 STAR Protoc 2024 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/39549235
Angiotensin-Converting Enzyme 2 Posttranslational Modifications and Implications for Hypertension and SARS-CoV-2: 2023 Lewis K. Dahl Memorial Lecture. Elgazzaz M, Filipeanu CM, Lazartigues E Hypertension (Dallas, Tex. : 1979) 38567498 Hypertension 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38567498
Ultrafast microfluidic synthesis of hierarchical triangular silver core-silica shell nanoplatelet toward enhanced cellular internalization. Hao N, Nie Y, Xu Z, Zhang JXJ Journal of colloid and interface science 30771632 J Colloid Interface Sci 2019 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/30771632
Microfluidic synthesis and on-chip enrichment application of two-dimensional hollow sandwich-like mesoporous silica nanosheet with water ripple-like surface. Hao N, Nie Y, Closson AB, Zhang JXJ Journal of colloid and interface science 30576991 J Colloid Interface Sci 2019 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/30576991
Implantable Cardiac Kirigami-Inspired Lead-Based Energy Harvester Fabricated by Enhanced Piezoelectric Composite Film. Xu Z, Jin C, Cabe A, Escobedo D, Gruslova A, Jenney S, Closson AB, Dong L, Chen Z, Feldman MD, Zhang JXJ Advanced healthcare materials 33434407 Adv Healthc Mater 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33434407
Microfluidic continuous flow synthesis of functional hollow spherical silica with hierarchical sponge-like large porous shell. Hao N, Nie Y, Xu Z, Closson AB, Usherwood T, J Zhang JX Chemical engineering journal (Lausanne, Switzerland : 1996) 31762686 Chem Eng J 2019 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/31762686
Silver nanoparticle on zinc oxide array for label-free detection of opioids through surface-enhanced raman spectroscopy. Zhang M, Jin C, Nie Y, Ren Y, Hao N, Xu Z, Dong L, Zhang JXJ RSC advances 35423637 RSC Adv 2021 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/35423637
Edge effect of strained bilayer nanofilms for tunable multistability and actuation. Hu N, Han X, Huang S, Grover HM, Yu X, Zhang LN, Trase I, Zhang JX, Zhang L, Dong LX, Chen Z Nanoscale 28067396 Nanoscale 2017 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/28067396
Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications. Hao N, Zhang M, Zhang JXJ Biomaterials science 31965125 Biomater Sci 2020 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/31965125
Tunable Buckled Beams with Mesoporous PVDF-TrFE/SWCNT Composite Film for Energy Harvesting. Xu Z, Liu Y, Dong L, Closson AB, Hao N, Oglesby M, Escobar GP, Fu S, Han X, Wen C, Liu J, Feldman MD, Chen Z, Zhang JXJ ACS applied materials & interfaces 30199624 ACS Appl Mater Interfaces 2018 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/30199624
Scalable Signature-Based Molecular Diagnostics Through On-chip Biomarker Profiling Coupled with Machine Learning. Molinski J, Tadimety A, Burklund A, Zhang JXJ Annals of biomedical engineering 32816167 Ann Biomed Eng 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32816167
Microfluidics-enabled rational design of ZnO micro-/nanoparticles with enhanced photocatalysis, cytotoxicity, and piezoelectric properties. Hao N, Xu Z, Nie Y, Jin C, Closson AB, Zhang M, Zhang JXJ Chemical engineering journal (Lausanne, Switzerland : 1996) 32831625 Chem Eng J 2019 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/32831625
Microfluidic In Situ Patterning of Silver Nanoparticles for Surface-Enhanced Raman Spectroscopic Sensing of Biomolecules. Nie Y, Jin C, Zhang JXJ ACS sensors 34148342 ACS Sens 2021 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/34148342
Combined immunomagnetic capture coupled with ultrasensitive plasmonic detection of circulating tumor cells in blood. Shen W, Song Y, Burklund A, Le B, Zhang R, Wang L, Xi Y, Qian K, Shen T, Zhang JXJ Biomedical microdevices 30417219 Biomed Microdevices 2018 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/30417219
Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing. Tadimety A, Zhang Y, Molinski JH, Palinski TJ, Tsongalis GJ, Zhang JXJ Methods in molecular biology (Clifton, N.J.) 34837175 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/34837175
Method for Inkjet-printing PEDOT:PSS polymer electrode arrays on piezoelectric PVDF-TrFE fibers. Closson A, Richards H, Xu Z, Jin C, Dong L, Zhang JXJ IEEE sensors journal 34899077 IEEE Sens J 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34899077
Microfluidics-mediated self-template synthesis of anisotropic hollow ellipsoidal mesoporous silica nanomaterials. Hao N, Nie Y, Tadimety A, Closson AB, Zhang JXJ Materials research letters 30854261 Mater Res Lett 2017 https://www.ncbi.nlm.nih.gov/pubmed/30854261
Flexible Piezoelectric Nanogenerators Using Metal-doped ZnO-PVDF Films. Jin C, Hao N, Xu Z, Trase I, Nie Y, Dong L, Closson A, Chen Z, Zhang JXJ Sensors and actuators. A, Physical 33380776 Sens Actuators A Phys 2020 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/33380776
Patterned Plasmonic Surfaces-Theory, Fabrication, and Applications in Biosensing. Chorsi HT, Zhu Y, Zhang JXJ Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems 29276365 J Microelectromech Syst 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/29276365
Microfluidics-enabled rapid manufacturing of hierarchical silica-magnetic microflower toward enhanced circulating tumor cell screening. Hao N , Nie Y , Tadimety A , Shen T , Zhang JXJ Biomaterials science 30375583 Biomater Sci 2018 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/30375583
Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis. Tadimety A, Closson A, Li C, Yi S, Shen T, Zhang JXJ Critical reviews in clinical laboratory sciences 29388456 Crit Rev Clin Lab Sci 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29388456
Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy. Hao N, Nie Y, Shen T, Zhang JXJ Lab on a chip 29923569 Lab Chip 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29923569
Microfluidics-Based Organism Isolation from Whole Blood: An Emerging Tool for Bloodstream Infection Diagnosis. Burklund A, Zhang JXJ Annals of biomedical engineering 30980291 Ann Biomed Eng 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30980291
Multifunctional Pacemaker Lead for Cardiac Energy Harvesting and Pressure Sensing. Dong L, Closson AB, Jin C, Nie Y, Cabe A, Escobedo D, Huang S, Trase I, Xu Z, Chen Z, Feldman MD, Zhang JXJ Advanced healthcare materials 32347010 Adv Healthc Mater 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32347010
Microfluidic enrichment of bacteria coupled to contact-free lysis on a magnetic polymer surface for downstream molecular detection. Burklund A, Petryk JD, Hoopes PJ, Zhang JXJ Biomicrofluidics 32642021 Biomicrofluidics 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32642021
Vibration-Energy-Harvesting System: Transduction Mechanisms, Frequency Tuning Techniques, and Biomechanical Applications. Dong L, Closson AB, Jin C, Trase I, Chen Z, Zhang JXJ Advanced materials technologies 33829079 Adv Mater Technol 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/33829079
Plasmonic nanosensors for point-of-care biomarker detection. Jin C, Wu Z, Molinski JH, Zhou J, Ren Y, Zhang JXJ Materials today. Bio 35514435 Mater Today Bio 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35514435
Flexible Electrostatic Transducer Array with Displacement Control for Haptic Sensing and Actuation. Trase I, Tan HZ, Chen Z, Zhang JXJ Sensors and actuators. A, Physical 33380777 Sens Actuators A Phys 2021 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/33380777
Microfluidics for silica biomaterials synthesis: opportunities and challenges. Hao N , Nie Y , Zhang JXJ Biomaterials science 30919847 Biomater Sci 2019 May 28 https://www.ncbi.nlm.nih.gov/pubmed/30919847
Ultrafast Synthesis of Multifunctional Submicrometer Hollow Silica Spheres in Microfluidic Spiral Channels. Nie Y, Hao N, Zhang JXJ Scientific reports 28974729 Sci Rep 2017 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/28974729
Biomimetic hierarchical walnut kernel-like and erythrocyte-like mesoporous silica nanomaterials: controllable synthesis and versatile applications. Hao N, Nie Y, Zhang JXJ Microporous and mesoporous materials : the official journal of the International Zeolite Association 29479288 Microporous Mesoporous Mater 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29479288
The fibrotic tumor stroma. Yamauchi M, Barker TH, Gibbons DL, Kurie JM The Journal of clinical investigation 29293090 J Clin Invest 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29293090
Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis. Cao L, Nicosia J, Larouche J, Zhang Y, Bachman H, Brown AC, Holmgren L, Barker TH ACS nano 28699736 ACS Nano 2017 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/28699736
Fibroblasts: The arbiters of extracellular matrix remodeling. DeLeon-Pennell KY, Barker TH, Lindsey ML Matrix biology : journal of the International Society for Matrix Biology 32504772 Matrix Biol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32504772
Strain-dependent glutathionylation of fibronectin fibers impacts mechano-chemical behavior and primes an integrin switch. Li W, Moretti L, Su X, Yeh CR, Torres MP, Barker TH Nature communications 39384749 Nat Commun 2024 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/39384749
Feeling Things Out: Bidirectional Signaling of the Cell-ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation. Miller AE, Hu P, Barker TH Advanced healthcare materials 32037719 Adv Healthc Mater 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32037719
Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis. Witherel CE, Abebayehu D, Barker TH, Spiller KL Advanced healthcare materials 30658015 Adv Healthc Mater 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30658015
αvβ3 Integrin drives fibroblast contraction and strain stiffening of soft provisional matrix during progressive fibrosis. Fiore VF, Wong SS, Tran C, Tan C, Xu W, Sulchek T, White ES, Hagood JS, Barker TH JCI insight 30333317 JCI Insight 2018 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/30333317
Fibroblasts: Diverse Cells Critical to Biomaterials Integration. Hannan RT, Peirce SM, Barker TH ACS biomaterials science & engineering 31440581 ACS Biomater Sci Eng 2018 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/31440581
Fibroblast mechanoperception instructs pulmonary developmental and pattern specification gene expression programs. Miller AE, Hu P, Hannan RT, Bhogaraju R, Abebayehu D, Civelek M, Barker TH PLoS genetics 41212903 PLoS Genet 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/41212903
Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology. Bingham GC, Lee F, Naba A, Barker TH Matrix biology : journal of the International Society for Matrix Biology 32416243 Matrix Biol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32416243
Multi-scale models of lung fibrosis. Leonard-Duke J, Evans S, Hannan RT, Barker TH, Bates JHT, Bonham CA, Moore BB, Kirschner DE, Peirce SM Matrix biology : journal of the International Society for Matrix Biology 32438056 Matrix Biol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32438056
LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol. Chambers DM, Moretti L, Zhang JJ, Cooper SW, Chambers DM, Santangelo PJ, Barker TH The Journal of biological chemistry 30108174 J Biol Chem 2018 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/30108174
Thy-1 in Integrin Mediated Mechanotransduction. Hu P, Barker TH Frontiers in cell and developmental biology 30859101 Front Cell Dev Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/30859101
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. Stefanelli VL, Choudhury S, Hu P, Liu Y, Schwenzer A, Yeh CR, Chambers DM, von Beck K, Li W, Segura T, Midwood KS, Torres M, Barker TH Matrix biology : journal of the International Society for Matrix Biology 31004743 Matrix Biol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31004743
Angiocrine functions of organ-specific endothelial cells. Rafii S, Butler JM, Ding BS Nature 26791722 Nature 2016 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/26791722
Open the gates: vascular neurocrine signaling mobilizes hematopoietic stem and progenitor cells. Itkin T, Gómez-Salinero JM, Rafii S The Journal of clinical investigation 29130939 J Clin Invest 2017 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/29130939
Platelets prime hematopoietic and vascular niche to drive angiocrine-mediated liver regeneration. Shido K, Chavez D, Cao Z, Ko J, Rafii S, Ding BS Signal transduction and targeted therapy 29201496 Signal Transduct Target Ther 2017 https://www.ncbi.nlm.nih.gov/pubmed/29201496
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression. Guo P, Poulos MG, Palikuqi B, Badwe CR, Lis R, Kunar B, Ding BS, Rabbany SY, Shido K, Butler JM, Rafii S The Journal of clinical investigation 29058691 J Clin Invest 2017 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/29058691
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Palikuqi B, Nguyen DT, Li G, Schreiner R, Pellegata AF, Liu Y, Redmond D, Geng F, Lin Y, Gómez-Salinero JM, Yokoyama M, Zumbo P, Zhang T, Kunar B, Witherspoon M, Han T, Tedeschi AM, Scottoni F, Lipkin SM, Dow L, Elemento O, Xiang JZ, Shido K, Spence JR, Zhou QJ, Schwartz RE, De Coppi P, Rabbany SY, Rafii S Nature 32908310 Nature 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32908310
In vitro conversion of adult murine endothelial cells to hematopoietic stem cells. Barcia Durán JG, Lis R, Lu TM, Rafii S Nature protocols 30429596 Nat Protoc 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30429596
Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells. Cao Z, Scandura JM, Inghirami GG, Shido K, Ding BS, Rafii S Cancer cell 27989801 Cancer Cell 2017 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/27989801
Sox17 drives functional engraftment of endothelium converted from non-vascular cells. Schachterle W, Badwe CR, Palikuqi B, Kunar B, Ginsberg M, Lis R, Yokoyama M, Elemento O, Scandura JM, Rafii S Nature communications 28091527 Nat Commun 2017 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/28091527
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Rafii S, Cao Z, Lis R, Siempos II, Chavez D, Shido K, Rabbany SY, Ding BS Nature cell biology 25621952 Nat Cell Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25621952
Morphological characterization of Etv2 vascular explants using fractal analysis and atomic force microscopy. Adelson RP, Palikuqi B, Weiss Z, Checco A, Schreiner R, Rafii S, Rabbany SY Microvascular research 34146583 Microvasc Res 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34146583
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice. Barcia Durán JG, Lu T, Houghton S, Geng F, Schreiner R, Xiang J, Rafii S, Redmond D, Lis R Communications biology 33767339 Commun Biol 2021 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/33767339
Systems Biology Analysis of Temporal Dynamics That Govern Endothelial Response to Cyclic Stretch. Lai MW, Chow N, Checco A, Kunar B, Redmond D, Rafii S, Rabbany SY Biomolecules 36551265 Biomolecules 2022 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/36551265
Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state. Ginsberg M, Schachterle W, Shido K, Rafii S Nature protocols 26540589 Nat Protoc 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26540589
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells. Liu Y, Giannopoulou EG, Wen D, Falciatori I, Elemento O, Allis CD, Rafii S, Seandel M Nature communications 27117588 Nat Commun 2016 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/27117588
Transplantation of Endothelial Cells to Mitigate Acute and Chronic Radiation Injury to Vital Organs. Rafii S, Ginsberg M, Scandura J, Butler JM, Ding BS Radiation research 27459700 Radiat Res 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27459700
Molecular determinants of nephron vascular specialization in the kidney. Barry DM, McMillan EA, Kunar B, Lis R, Zhang T, Lu T, Daniel E, Yokoyama M, Gomez-Salinero JM, Sureshbabu A, Cleaver O, Di Lorenzo A, Choi ME, Xiang J, Redmond D, Rabbany SY, Muthukumar T, Rafii S Nature communications 31836710 Nat Commun 2019 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/31836710
Generation of BMEC Lines and in vitro BMEC-HSPC Co-culture Assays. Guo P, Rafii S Bio-protocol 34532536 Bio Protoc 2018 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/34532536
Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Lis R, Karrasch CC, Poulos MG, Kunar B, Redmond D, Duran JGB, Badwe CR, Schachterle W, Ginsberg M, Xiang J, Tabrizi AR, Shido K, Rosenwaks Z, Elemento O, Speck NA, Butler JM, Scandura JM, Rafii S Nature 28514438 Nature 2017 May 25 https://www.ncbi.nlm.nih.gov/pubmed/28514438
Novelties in pharmacological management of cardiopulmonary resuscitation. Bartos JA, Yannopoulos D Current opinion in critical care 23995130 Curr Opin Crit Care 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23995130
Sounds Impossible, but It's Knot. Smith LE, Heath DR, Riess ML Anesthesiology 30632983 Anesthesiology 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30632983
Role of epinephrine and extracorporeal membrane oxygenation in the management of ischemic refractory ventricular fibrillation: a randomized trial in pigs. Bartos JA, Voicu S, Matsuura TR, Tsangaris A, Sideris G, Oestreich BA, George SA, Olson M, Shekar KC, Rees JN, Carlson K, Sebastian P, McKnite S, Raveendran G, Aufderheide TP, Yannopoulos D JACC. Basic to translational science 29152600 JACC Basic Transl Sci 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/29152600
Video laryngoscopic oral intubation in rats: a simple and effective method. Balzer C, Cleveland WJ, Jinka TR, Riess ML American journal of physiology. Lung cellular and molecular physiology 32233786 Am J Physiol Lung Cell Mol Physiol 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32233786
PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts. Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS Cells 31968546 Cells 2020 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/31968546
Therapeutic Hypothermia in Children. Riess ML, Aufderheide TP, Yannopoulos D The New England journal of medicine 26332560 N Engl J Med 2015 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/26332560
Arterial flow waveforms, vascular tone, and chronic fatigue: a case report. Zundel MT, Pattyn M, Chelimsky TC, Riess ML Autonomic neuroscience : basic & clinical 25817901 Auton Neurosci 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25817901
Venous waveform analysis detects acute right ventricular failure in a rat respiratory arrest model. Lefevre RJ, Barajas MB, Balzer C, Baudenbacher FJ, Riess ML, Staudt G, Hernandez A, Eagle SS Pediatric research 36042330 Pediatr Res 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36042330
Design and Implementation of a Rat Ex Vivo Lung Perfusion Model. Cleveland WJ, Hees JE, Balzer C, Douglas HF, Stevens T, Riess ML Journal of visualized experiments : JoVE 37306411 J Vis Exp 2023 May 26 https://www.ncbi.nlm.nih.gov/pubmed/37306411
Lipid emulsion enhances cardiac performance after ischemia-reperfusion in isolated hearts from summer-active arctic ground squirrels. Salzman MM, Cheng Q, Deklotz RJ, Dulai GK, Douglas HF, Dikalova AE, Weihrauch D, Barnes BM, Riess ML Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 28364393 J Comp Physiol B 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28364393
New Developments in Cardiac Arrest Management. Riess ML Advances in anesthesia 28867873 Adv Anesth 2016 https://www.ncbi.nlm.nih.gov/pubmed/28867873
Reperfusion injury protection during Basic Life Support improves circulation and survival outcomes in a porcine model of prolonged cardiac arrest. Debaty G, Lurie K, Metzger A, Lick M, Bartos JA, Rees JN, McKnite S, Puertas L, Pepe P, Fowler R, Yannopoulos D Resuscitation 27211835 Resuscitation 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27211835
Minnesota Resuscitation Consortium's Advanced Perfusion and Reperfusion Cardiac Life Support Strategy for Out-of-Hospital Refractory Ventricular Fibrillation. Yannopoulos D, Bartos JA, Martin C, Raveendran G, Missov E, Conterato M, Frascone RJ, Trembley A, Sipprell K, John R, George S, Carlson K, Brunsvold ME, Garcia S, Aufderheide TP Journal of the American Heart Association 27412906 J Am Heart Assoc 2016 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/27412906
Outcomes of intermediate-risk patients treated with transcatheter and surgical aortic valve replacement in the Veterans Affairs Healthcare System: A single center 20-year experience. Garcia S, Kelly R, Mbai M, Gurevich S, Oestreich B, Yannopoulos D, Adabag S Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 29316204 Catheter Cardiovasc Interv 2018 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/29316204
Opioid-induced cardioprotection. Tanaka K, Kersten JR, Riess ML Current pharmaceutical design 24502571 Curr Pharm Des 2014 https://www.ncbi.nlm.nih.gov/pubmed/24502571
Intralipid Increases Nitric Oxide Release from Human Endothelial Cells During Oxidative Stress. Weihrauch D, Shumpert SD, Larson ME, McVey N, Krolikowski JG, Bamkole O, Riess ML JPEN. Journal of parenteral and enteral nutrition 32291784 JPEN J Parenter Enteral Nutr 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/32291784
Poloxamer 188 Exerts Direct Protective Effects on Mouse Brain Microvascular Endothelial Cells in an In Vitro Traumatic Brain Injury Model. Lotze FP, Riess ML Biomedicines 34440247 Biomedicines 2021 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/34440247
Venous Waveform Analysis Correlates With Echocardiography in Detecting Hypovolemia in a Rat Hemorrhage Model. Lefevre RJ, Balzer C, Baudenbacher FJ, Riess ML, Hernandez A, Eagle SS Seminars in cardiothoracic and vascular anesthesia 32957831 Semin Cardiothorac Vasc Anesth 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/32957831
Mechanical adjuncts for cardiocerebral resuscitation. Riess ML, Balzer C Expert review of medical devices 31353970 Expert Rev Med Devices 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31353970
Total intravenous versus inhaled anesthesia in transsphenoidal tumor surgery. Gollapudy S, Poetker DM, Sidhu J, Riess ML American journal of otolaryngology 30017373 Am J Otolaryngol 2018 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/30017373
Noninvasively Measured Hemoglobin Concentration Reflects Arterial Hemoglobin Concentration Before but Not After Cardiopulmonary Bypass in Patients Undergoing Coronary Artery or Valve Surgery. Riess ML, Pagel PS Journal of cardiothoracic and vascular anesthesia 27475734 J Cardiothorac Vasc Anesth 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27475734
Identifying Candidates for Advanced Hemodynamic Support After Cardiac Arrest. Bartos JA, Doonan AL, Yannopoulos D Circulation 29335287 Circulation 2018 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/29335287
Early Effects of Prolonged Cardiac Arrest and Ischemic Postconditioning during Cardiopulmonary Resuscitation on Cardiac and Brain Mitochondrial Function in Pigs. Matsuura TR, Bartos JA, Tsangaris A, Shekar KC, Olson MD, Riess ML, Bienengraeber M, Aufderheide TP, Neumar RW, Rees JN, McKnite SH, Dikalova AE, Dikalov SI, Douglas HF, Yannopoulos D Resuscitation 28408349 Resuscitation 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28408349
Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest. Bartos JA, Matsuura TR, Sarraf M, Youngquist ST, McKnite SH, Rees JN, Sloper DT, Bates FS, Segal N, Debaty G, Lurie KG, Neumar RW, Metzger JM, Riess ML, Yannopoulos D Resuscitation 25447036 Resuscitation 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25447036
Non-invasive cardiac output monitoring during sinus surgery. Gollapudy S, Riess ML Journal of anesthesia 25543335 J Anesth 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/25543335
Surgical Field Visualization during Functional Endoscopic Sinus Surgery: Comparison of Propofol- vs Desflurane-Based Anesthesia. Gollapudy S, Gashkoff DA, Poetker DM, Loehrl TA, Riess ML Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 32450733 Otolaryngol Head Neck Surg 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32450733
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models. Meyer LJ, Lotze FP, Riess ML Journal of pharmacological and toxicological methods 35149185 J Pharmacol Toxicol Methods 2022 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/35149185
Buffer glucose adjustment affects myocardial function after ischemia-reperfusion in long-term diabetic rat isolated hearts. Balzer C, Cleveland WJ, Li Z, Riess ML Physiological reports 36324287 Physiol Rep 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36324287
A new method to predict return of spontaneous circulation by peripheral intravenous analysis during cardiopulmonary resuscitation: a rat model pilot study. Balzer C, Eagle SS, Baudenbacher FJ, Riess ML Intensive care medicine experimental 39531090 Intensive Care Med Exp 2024 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/39531090
Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production. Chen G, Douglas HF, Li Z, Cleveland WJ, Balzer C, Yannopoulos D, Chen IY, Obal D, Riess ML Scientific reports 40307302 Sci Rep 2025 Apr 30 https://www.ncbi.nlm.nih.gov/pubmed/40307302
Anaesthetic Postconditioning at the Initiation of CPR Improves Myocardial and Mitochondrial Function in a Pig Model of Prolonged Untreated Ventricular Fibrillation. Riess ML, Matsuura TR, Bartos JA, Bienengraeber M, Aldakkak M, McKnite SH, Rees JN, Aufderheide TP, Sarraf M, Neumar RW, Yannopoulos D Resuscitation 25281906 Resuscitation 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25281906
MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway. Qiao S, Olson JM, Paterson M, Yan Y, Zaja I, Liu Y, Riess ML, Kersten JR, Liang M, Warltier DC, Bosnjak ZJ, Ge ZD Anesthesiology 26259139 Anesthesiology 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26259139
Early Access to the Cardiac Catheterization Laboratory for Patients Resuscitated From Cardiac Arrest Due to a Shockable Rhythm: The Minnesota Resuscitation Consortium Twin Cities Unified Protocol. Garcia S, Drexel T, Bekwelem W, Raveendran G, Caldwell E, Hodgson L, Wang Q, Adabag S, Mahoney B, Frascone R, Helmer G, Lick C, Conterato M, Baran K, Bart B, Bachour F, Roh S, Panetta C, Stark R, Haugland M, Mooney M, Wesley K, Yannopoulos D Journal of the American Heart Association 26744380 J Am Heart Assoc 2016 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/26744380
Sodium nitroprusside enhanced cardiopulmonary resuscitation improves short term survival in a porcine model of ischemic refractory ventricular fibrillation. Yannopoulos D, Bartos JA, George SA, Sideris G, Voicu S, Oestreich B, Matsuura T, Shekar K, Rees J, Aufderheide TP Resuscitation 27771299 Resuscitation 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27771299
Increasing body mass index predicts increasing difficulty, failure rate, and time to discovery of failure of epidural anesthesia in laboring patients. Kula AO, Riess ML, Ellinas EH Journal of clinical anesthesia 28235511 J Clin Anesth 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/28235511
Identifying Important Gaps in Randomized Controlled Trials of Adult Cardiac Arrest Treatments: A Systematic Review of the Published Literature. Sinha SS, Sukul D, Lazarus JJ, Polavarapu V, Chan PS, Neumar RW, Nallamothu BK Circulation. Cardiovascular quality and outcomes 27756794 Circ Cardiovasc Qual Outcomes 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27756794
Potential Effects of Poloxamer 188 on Rat Isolated Brain Mitochondria after Oxidative Stress In Vivo and In Vitro. Pille JA, Riess ML Brain sciences 33477541 Brain Sci 2021 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/33477541
Poloxamer 188 Protects Isolated Adult Mouse Cardiomyocytes from Reoxygenation Injury. Salzman MM, Bartos JA, Yannopoulos D, Riess ML Pharmacology research & perspectives 33073927 Pharmacol Res Perspect 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33073927
High central venous pressure amplitude predicts successful defibrillation in a porcine model of cardiac arrest. Balzer C, Eagle SS, Yannopoulos D, Aufderheide TP, Riess ML Resuscitation 36736947 Resuscitation 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36736947
The relationship between red blood cell deformability metrics and perfusion of an artificial microvascular network. Sosa JM, Nielsen ND, Vignes SM, Chen TG, Shevkoplyas SS Clinical hemorheology and microcirculation 23603326 Clin Hemorheol Microcirc 2014 https://www.ncbi.nlm.nih.gov/pubmed/23603326
Centrifugation-free washing reduces buildup of potassium and free hemoglobin in washed red blood cells after the procedure. Vörös E, Lu M, Lezzar D, Shevkoplyas SS American journal of hematology 30184257 Am J Hematol 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30184257
Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (Fåhraeus effect) in an artificial microvascular network. Reinhart WH, Piety NZ, Shevkoplyas SS Microcirculation (New York, N.Y. : 1994) 28801994 Microcirculation 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28801994
Dynamics of shape recovery by stored red blood cells during washing at the single cell level. Lu M, Shevkoplyas SS Transfusion 32748970 Transfusion 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32748970
Deterioration of red blood cell mechanical properties is reduced in anaerobic storage. Burns JM, Yoshida T, Dumont LJ, Yang X, Piety NZ, Shevkoplyas SS Blood transfusion = Trasfusione del sangue 26674833 Blood Transfus 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26674833
A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma. Xia H, Strachan BC, Gifford SC, Shevkoplyas SS Scientific reports 27775049 Sci Rep 2016 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/27775049
Deep ensemble learning enables highly accurate classification of stored red blood cell morphology. Routt AH, Yang N, Piety NZ, Lu M, Shevkoplyas SS Scientific reports 36823298 Sci Rep 2023 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/36823298
Controlled incremental filtration: a simplified approach to design and fabrication of high-throughput microfluidic devices for selective enrichment of particles. Gifford SC, Spillane AM, Vignes SM, Shevkoplyas SS Lab on a chip 25254358 Lab Chip 2014 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/25254358
A rapid paper-based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease. Piety NZ, Yang X, Lezzar D, George A, Shevkoplyas SS American journal of hematology 25689370 Am J Hematol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25689370
Substituting Sodium Hydrosulfite with Sodium Metabisulfite Improves Long-Term Stability of a Distributable Paper-Based Test Kit for Point-of-Care Screening for Sickle Cell Anemia. Torabian K, Lezzar D, Piety NZ, George A, Shevkoplyas SS Biosensors 28930183 Biosensors (Basel) 2017 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/28930183
Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study. Xia H, Khanal G, Strachan BC, Vörös E, Piety NZ, Gifford SC, Shevkoplyas SS Blood transfusion = Trasfusione del sangue 28686152 Blood Transfus 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28686152
Optimal hematocrit in an artificial microvascular network. Piety NZ, Reinhart WH, Stutz J, Shevkoplyas SS Transfusion 28681482 Transfusion 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28681482
A Paper-Based Test for Screening Newborns for Sickle Cell Disease. Piety NZ, George A, Serrano S, Lanzi MR, Patel PR, Noli MP, Kahan S, Nirenberg D, Camanda JF, Airewele G, Shevkoplyas SS Scientific reports 28367971 Sci Rep 2017 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/28367971
Density-based separation in multiphase systems provides a simple method to identify sickle cell disease. Kumar AA, Patton MR, Hennek JW, Lee SY, D'Alesio-Spina G, Yang X, Kanter J, Shevkoplyas SS, Brugnara C, Whitesides GM Proceedings of the National Academy of Sciences of the United States of America 25197072 Proc Natl Acad Sci U S A 2014 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/25197072
Washing stored red blood cells in an albumin solution improves their morphologic and hemorheologic properties. Reinhart WH, Piety NZ, Deuel JW, Makhro A, Schulzki T, Bogdanov N, Goede JS, Bogdanova A, Abidi R, Shevkoplyas SS Transfusion 25752902 Transfusion 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/25752902
Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network. Lu M, Kanne CK, Reddington RC, Lezzar DL, Sheehan VA, Shevkoplyas SS Frontiers in physiology 33995119 Front Physiol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33995119
Microfluidic capillary networks are more sensitive than ektacytometry to the decline of red blood cell deformability induced by storage. Piety NZ, Stutz J, Yilmaz N, Xia H, Yoshida T, Shevkoplyas SS Scientific reports 33436749 Sci Rep 2021 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/33436749
Traditional and emerging technologies for washing and volume reducing blood products. Lu M, Lezzar DL, Vörös E, Shevkoplyas SS Journal of blood medicine 30655711 J Blood Med 2019 https://www.ncbi.nlm.nih.gov/pubmed/30655711
Centrifugation-free washing: A novel approach for removing immunoglobulin A from stored red blood cells. Vörös E, Piety NZ, Strachan BC, Lu M, Shevkoplyas SS American journal of hematology 29285804 Am J Hematol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29285804
pH-Responsive Charge-Conversion Progelator Peptides. Carlini AS, Choi W, McCallum NC, Gianneschi NC Advanced functional materials 36530181 Adv Funct Mater 2021 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/36530181
Development of a Synthetic 3-ketosteroid Δ(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE Scientific reports 30979909 Sci Rep 2019 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/30979909
Angiophagy prevents early embolus washout but recanalizes microvessels through embolus extravasation. Grutzendler J, Murikinati S, Hiner B, Ji L, Lam CK, Yoo T, Gupta S, Hafler BP, Adelman RA, Yuan P, Rodriguez G Science translational medicine 24598589 Sci Transl Med 2014 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/24598589
In vivo imaging of cerebral microvascular plasticity from birth to death. Harb R, Whiteus C, Freitas C, Grutzendler J Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 23093067 J Cereb Blood Flow Metab 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23093067
In vivo imaging of oligodendrocytes with sulforhodamine 101. Hill RA, Grutzendler J Nature methods 25357236 Nat Methods 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25357236
Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV Frontiers in neuroscience 26941593 Front Neurosci 2016 https://www.ncbi.nlm.nih.gov/pubmed/26941593
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division. Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A Nature neuroscience 25262495 Nat Neurosci 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25262495
Angiophagy: mechanism of microvascular recanalization independent of the fibrinolytic system. Grutzendler J Stroke 23709741 Stroke 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23709741
Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Whiteus C, Freitas C, Grutzendler J Nature 24305053 Nature 2014 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/24305053
Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging. Condello C, Yuan P, Grutzendler J Biological psychiatry 29169609 Biol Psychiatry 2018 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/29169609
Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy. Schain AJ, Hill RA, Grutzendler J Nature medicine 24681598 Nat Med 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24681598
Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. Hill RA, Tong L, Yuan P, Murikinati S, Gupta S, Grutzendler J Neuron 26119027 Neuron 2015 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/26119027
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Condello C, Yuan P, Schain A, Grutzendler J Nature communications 25630253 Nat Commun 2015 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/25630253
Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. Yuan P, Grutzendler J The Journal of neuroscience : the official journal of the Society for Neuroscience 26758850 J Neurosci 2016 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/26758850
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J Neuron 27196974 Neuron 2016 May 18 https://www.ncbi.nlm.nih.gov/pubmed/27196974
Imaging and optogenetic modulation of vascular mural cells in the live brain. Tong L, Hill RA, Damisah EC, Murray KN, Yuan P, Bordey A, Grutzendler J Nature protocols 33299155 Nat Protoc 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33299155
The major transitions of life from a network perspective. Suki B Frontiers in physiology 22514542 Front Physiol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22514542
A mechanical design principle for tissue structure and function in the airway tree. LaPrad AS, Lutchen KR, Suki B PLoS computational biology 23737742 PLoS Comput Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23737742
Proteoglycans maintain lung stability in an elastase-treated mouse model of emphysema. Takahashi A, Majumdar A, Parameswaran H, Bartolák-Suki E, Suki B American journal of respiratory cell and molecular biology 24450478 Am J Respir Cell Mol Biol 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24450478
Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways. Bartolák-Suki E, LaPrad AS, Harvey BC, Suki B, Lutchen KR PloS one 24740101 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24740101
A computational model of the response of adherent cells to stretch and changes in substrate stiffness. Parameswaran H, Lutchen KR, Suki B Journal of applied physiology (Bethesda, Md. : 1985) 24408996 J Appl Physiol (1985) 2014 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/24408996
Acute mechanical forces cause deterioration in lung structure and function in elastase-induced emphysema. Szabari MV, Parameswaran H, Sato S, Hantos Z, Bartolák-Suki E, Suki B American journal of physiology. Lung cellular and molecular physiology 22865550 Am J Physiol Lung Cell Mol Physiol 2012 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/22865550
Microtubule dynamics regulate cyclic stretch-induced cell alignment in human airway smooth muscle cells. Morioka M, Parameswaran H, Naruse K, Kondo M, Sokabe M, Hasegawa Y, Suki B, Ito S PloS one 22022610 PLoS One 2011 https://www.ncbi.nlm.nih.gov/pubmed/22022610
Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function. Bartolák-Suki E, Imsirovic J, Parameswaran H, Wellman TJ, Martinez N, Allen PG, Frey U, Suki B Nature materials 26213900 Nat Mater 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26213900
Homeostatic maintenance via degradation and repair of elastic fibers under tension. Alves C, Araújo AD, Oliveira CL, Imsirovic J, Bartolák-Suki E, Andrade JS, Suki B Scientific reports 27279029 Sci Rep 2016 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/27279029
Lung tissue mechanics as an emergent phenomenon. Suki B, Bates JH Journal of applied physiology (Bethesda, Md. : 1985) 21212247 J Appl Physiol (1985) 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21212247
Variable ventilation improves ventilation and lung compliance in preterm lambs. Pillow JJ, Musk GC, McLean CM, Polglase GR, Dalton RG, Jobe AH, Suki B Intensive care medicine 21567115 Intensive Care Med 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21567115
Regulatory Roles of Fluctuation-Driven Mechanotransduction in Cell Function. Suki B, Parameswaran H, Imsirovic J, Bartolák-Suki E Physiology (Bethesda, Md.) 27511461 Physiology (Bethesda) 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27511461
Scale dependence of structure-function relationship in the emphysematous mouse lung. Sato S, Bartolák-Suki E, Parameswaran H, Hamakawa H, Suki B Frontiers in physiology 26029115 Front Physiol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26029115
A novel device to stretch multiple tissue samples with variable patterns: application for mRNA regulation in tissue-engineered constructs. Imsirovic J, Derricks K, Buczek-Thomas JA, Rich CB, Nugent MA, Suki B Biomatter 23628870 Biomatter 2013 Jul-Sep https://www.ncbi.nlm.nih.gov/pubmed/23628870
Computational modeling helps uncover mechanisms related to the progression of emphysema. Suki B, Parameswaran H Drug discovery today. Disease models 24904681 Drug Discov Today Dis Models 2014 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/24904681
Combined effects of ventilation mode and positive end-expiratory pressure on mechanics, gas exchange and the epithelium in mice with acute lung injury. Thammanomai A, Hamakawa H, Bartolák-Suki E, Suki B PloS one 23326543 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/23326543
Variable ventilation enhances ventilation without exacerbating injury in preterm lambs with respiratory distress syndrome. Berry CA, Suki B, Polglase GR, Pillow JJ Pediatric research 22805999 Pediatr Res 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22805999
Design of a Novel Equi-Biaxial Stretcher for Live Cellular and Subcellular Imaging. Imsirovic J, Wellman TJ, Mondoñedo JR, Bartolák-Suki E, Suki B PloS one 26466363 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/26466363
Correlated variability in the breathing pattern and end-expiratory lung volumes in conscious humans. Dellaca RL, Aliverti A, Lo Mauro A, Lutchen KR, Pedotti A, Suki B PloS one 25803710 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/25803710
Aging impairs smooth muscle-mediated regulation of aortic stiffness: a defect in shock absorption function? Gao YZ, Saphirstein RJ, Yamin R, Suki B, Morgan KG American journal of physiology. Heart and circulatory physiology 25128168 Am J Physiol Heart Circ Physiol 2014 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/25128168
Emphysema and mechanical stress-induced lung remodeling. Suki B, Sato S, Parameswaran H, Szabari MV, Takahashi A, Bartolák-Suki E Physiology (Bethesda, Md.) 24186935 Physiology (Bethesda) 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24186935
Epithelial and endothelial damage induced by mechanical ventilation modes. Suki B, Hubmayr R Current opinion in critical care 24300621 Curr Opin Crit Care 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24300621
Monitoring the temporal changes of respiratory resistance: a novel test for the management of asthma. Gulotta C, Suki B, Brusasco V, Pellegrino R, Gobbi A, Pedotti A, Dellacà RL American journal of respiratory and critical care medicine 22707741 Am J Respir Crit Care Med 2012 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/22707741
Complexity and emergent phenomena. Suki B, Bates JH, Frey U Comprehensive Physiology 23737210 Compr Physiol 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/23737210
A network model of correlated growth of tissue stiffening in pulmonary fibrosis. Oliveira CL, Bates JH, Suki B New journal of physics 25484613 New J Phys 2014 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/25484613
Effects of recruitment/derecruitment dynamics on the efficacy of variable ventilation. Ma B, Suki B, Bates JH Journal of applied physiology (Bethesda, Md. : 1985) 21372101 J Appl Physiol (1985) 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21372101
Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells. Sanders KM, Kito Y, Hwang SJ, Ward SM Physiology (Bethesda, Md.) 27488743 Physiology (Bethesda) 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27488743
Efficient formation of single-copy human artificial chromosomes. Gambogi CW, Birchak GJ, Mer E, Brown DM, Yankson G, Kixmoeller K, Gavade JN, Espinoza JL, Kashyap P, Dupont CL, Logsdon GA, Heun P, Glass JI, Black BE Science (New York, N.Y.) 38513017 Science 2024 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/38513017
Efficient Formation of Single-copy Human Artificial Chromosomes. Gambogi CW, Mer E, Brown DM, Yankson G, Gavade JN, Logsdon GA, Heun P, Glass JI, Black BE bioRxiv : the preprint server for biology 37546784 bioRxiv 2023 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/37546784
Rapid assembly of functional modules for generating human artificial chromosome constructs compatible with epigenetic centromere seeding. Birchak GJ, Gibson DG, Allu PK, Kashyap P, Glass JI, Black BE Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 41324764 Chromosome Res 2025 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/41324764
Protein-only centromeric chromatin assembly streamlines human artificial chromosome formation. Birchak GJ, Allu PK, Kashyap P, Anbalagan GK, Chuang SC, Logsdon GA, Gibson DG, Glass JI, Black BE bioRxiv : the preprint server for biology 41659392 bioRxiv 2026 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/41659392
Rapid assembly of functional modules for generating human artificial chromosome constructs compatible with epigenetic centromere seeding. Birchak GJ, Gibson DG, Allu PK, Kashyap P, Glass JI, Black BE bioRxiv : the preprint server for biology 41256567 bioRxiv 2025 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/41256567
Independent phenotypic plasticity axes define distinct obesity sub-types. Yang CH, Fagnocchi L, Apostle S, Wegert V, Casaní-Galdón S, Landgraf K, Panzeri I, Dror E, Heyne S, Wörpel T, Chandler DP, Lu D, Yang T, Gibbons E, Guerreiro R, Bras J, Thomasen M, Grunnet LG, Vaag AA, Gillberg L, Grundberg E, Conesa A, Körner A, PERMUTE, Pospisilik JA Nature metabolism 36097183 Nat Metab 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36097183
An acute microglial metabolic response controls metabolism and improves memory. Drougard A, Ma EH, Wegert V, Sheldon R, Panzeri I, Vatsa N, Apostle S, Fagnocchi L, Schaf J, Gossens K, Völker J, Pang S, Bremser A, Dror E, Giacona F, Sagar, Henderson MX, Prinz M, Jones RG, Pospisilik JA bioRxiv : the preprint server for biology 37066282 bioRxiv 2024 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/37066282
Isolation and Processing of Murine White Adipocytes for Transcriptome and Epigenome Analyses. Yang CH, Longinotto J, Panzeri I, Arrigoni L, Wegert V, Heyne S, Seifert G, Lempradl A, Bönisch U, Pospisilik JA Journal of visualized experiments : JoVE 35786676 J Vis Exp 2022 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/35786676
BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise. Madaj Z, Ding M, Khoo C, Tokarski E, Fagnocchi L, PERMUTE, Li Z, Riordan J, Pospisilik JA, Nadeau JH, Lary CW, Triche TJ bioRxiv : the preprint server for biology 40502166 bioRxiv 2025 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/40502166
An acute microglial metabolic response controls metabolism and improves memory. Drougard A, Ma EH, Wegert V, Sheldon R, Panzeri I, Vatsa N, Apostle S, Fagnocchi L, Schaf J, Gossens K, Völker J, Pang S, Bremser A, Dror E, Giacona F, Sagar S, Henderson MX, Prinz M, Jones RG, Pospisilik JA eLife 39625057 Elife 2024 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/39625057
Chronic obesity does not alter cancer incidence in Trp53 (R270H/+) mice. Panzeri I, Madaj Z, Fagnocchi L, Apostle S, Tompkins M, Hostetter G, Pospisilik JA bioRxiv : the preprint server for biology 39463991 bioRxiv 2025 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/39463991
Comparison of Lysis and Amplification Methodologies for Optimal 16S rRNA Gene Profiling for Human and Mouse Microbiome Studies. Rastegari F, Driscoll M, Riordan JD, Nadeau JH, Johnson JS, Weinstock GM International journal of molecular sciences 39940948 Int J Mol Sci 2025 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/39940948
Epigenetic dosage identifies two major and functionally distinct β cell subtypes. Dror E, Fagnocchi L, Wegert V, Apostle S, Grimaldi B, Gruber T, Panzeri I, Heyne S, Höffler KD, Kreiner V, Ching R, Tsai-Hsiu Lu T, Semwal A, Johnson B, Senapati P, Lempradl A, Schones D, Imhof A, Shen H, Pospisilik JA Cell metabolism 36948185 Cell Metab 2023 May 2 https://www.ncbi.nlm.nih.gov/pubmed/36948185
Developmental priming of cancer susceptibility. Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Chih-Hsiang Y, Bergsma A, Drougard A, Dror E, PERMUTE, Chandler D, Schramek D, Triche TJ Jr, Pospisilik JA bioRxiv : the preprint server for biology 37745326 bioRxiv 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37745326
The DECON pilot project investigates predictive markers for successful bariatric surgery. Seifert G, Fagnocchi L, Edozie M, Herrmann S, Baumann H, Panzeri I, Mewes S, Aicher D, Runkel M, Lässle C, Fink J, Marjanovic G, Fichtner-Feigl S, Pospisilik JA Scientific reports 37591977 Sci Rep 2023 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/37591977
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states. Panzeri I, Fagnocchi L, Apostle S, Tompkins M, Wolfrum E, Madaj Z, Hostetter G, Liu Y, Schaefer K, Yang CH, Bergsma A, Drougard A, Dror E, PERMUTE, Chandler DP, Schramek D, Triche TJ Jr, Pospisilik JA Nature cancer 39856421 Nat Cancer 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39856421
Regulatory and evolutionary adaptation of yeast to acute lethal ethanol stress. Yang J, Tavazoie S PloS one 33170850 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/33170850
Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization. Moy RH, Nguyen A, Loo JM, Yamaguchi N, Kajba CM, Santhanam B, Ostendorf BN, Wu YG, Tavazoie S, Tavazoie SF Developmental cell 35487218 Dev Cell 2022 May 9 https://www.ncbi.nlm.nih.gov/pubmed/35487218
A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention. Yamaguchi N, Wu YG, Ravetch E, Takahashi M, Khan AG, Hayashi A, Mei W, Hsu D, Umeda S, de Stanchina E, Lorenz IC, Iacobuzio-Donahue CA, Tavazoie SF Cancer discovery 39028915 Cancer Discov 2024 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/39028915
In vivo mRNA display enables large-scale proteomics by next generation sequencing. Oikonomou P, Salatino R, Tavazoie S Proceedings of the National Academy of Sciences of the United States of America 33037152 Proc Natl Acad Sci U S A 2020 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/33037152
Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, Abdel Messih M, Takacs CM, Yartseva V, Oikonomou P, Christiano R, Stoeckius M, Lau S, Lee MT, Beaudoin JD, Musaev D, Darwich-Codore H, Walther TC, Tavazoie S, Cifuentes D, Giraldez AJ Genome research 31227602 Genome Res 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31227602
An inducible CRISPR interference library for genetic interrogation of Saccharomyces cerevisiae biology. Momen-Roknabadi A, Oikonomou P, Zegans M, Tavazoie S Communications biology 33247197 Commun Biol 2020 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/33247197
Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity. Masoudi N, Tavazoie S, Glenwinkel L, Ryu L, Kim K, Hobert O PLoS biology 29672507 PLoS Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29672507
Regulation of Sex-biased Gene Expression by the Ancestral X-Y Chromosomal Gene Pair Kdm5c-Kdm5d. Malcore RM, Samanta MK, Kalantry S, Iwase S bioRxiv : the preprint server for biology 39484414 bioRxiv 2024 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/39484414
Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice. Cincotta C, Murawski NJ, Grella SL, McKissick O, Doucette E, Ramirez S Hippocampus 32946184 Hippocampus 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32946184
Social reactivation of fear engrams enhances memory recall. Finkelstein AB, Leblanc H, Cole RH, Gallerani T, Vieira A, Zaki Y, Ramirez S Proceedings of the National Academy of Sciences of the United States of America 35286206 Proc Natl Acad Sci U S A 2022 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/35286206
Immediate-early genes Arc and c-Fos show divergent brain-wide expression following contextual fear conditioning. Bulthuis NE, Quintana LI, Stackmann M, Denny CA Communications biology 41068278 Commun Biol 2025 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/41068278
A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis. Jin M, Ogundare SO, Lanio M, Sorid S, Whye AR, Santos SL, Franceschini A, Denny CA bioRxiv : the preprint server for biology 39071434 bioRxiv 2025 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/39071434
GluN2B on Adult-Born Granule Cells Modulates (R,S)-Ketamine's Rapid-Acting Effects in Mice. Bulthuis NE, McGowan JC, Ladner LR, LaGamma CT, Lim SC, Shubeck CX, Brachman RA, Sydnor E, Pavlova IP, Seo DO, Drew MR, Denny CA The international journal of neuropsychopharmacology 39240140 Int J Neuropsychopharmacol 2024 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/39240140
Erasable hippocampal neural signatures predict memory discrimination. Kinsky NR, Orlin DJ, Ruesch EA, Kim B, Coello S, Diba K, Ramirez S Cell reports 40057951 Cell Rep 2025 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/40057951
Hippocampal fear engrams modulate ethanol-induced maladaptive contextual generalization in mice. Cincotta C, Ruesch E, Senne R, Ramirez S Hippocampus 35950345 Hippocampus 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35950345
Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior. Chen BK, Luna VM, Shannon ME, Hunsberger HC, Mastrodonato A, Stackmann M, McGowan JC, Rubinstenn G, Denny CA Biological psychiatry 34274107 Biol Psychiatry 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34274107
Distinct hippocampal engrams control extinction and relapse of fear memory. Lacagnina AF, Brockway ET, Crovetti CR, Shue F, McCarty MJ, Sattler KP, Lim SC, Santos SL, Denny CA, Drew MR Nature neuroscience 30936555 Nat Neurosci 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30936555
Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits. Chen BK, Le Pen G, Eckmier A, Rubinstenn G, Jay TM, Denny CA The international journal of neuropsychopharmacology 33631001 Int J Neuropsychopharmacol 2021 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/33631001
Propranolol Decreases Fear Expression by Modulating Fear Memory Traces. Leal Santos S, Stackmann M, Muñoz Zamora A, Mastrodonato A, De Landri AV, Vaughan N, Chen BK, Lanio M, Denny CA Biological psychiatry 33766406 Biol Psychiatry 2021 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/33766406
Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights from (Female) Mice and (Wo)Men. Hunsberger HC, Lee S, Jin M, Lanio M, Whye A, Cha J, Scarlata M, Jayaseelan K, Denny CA bioRxiv : the preprint server for biology 37503264 bioRxiv 2023 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/37503264
Prophylactic (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles. Mastrodonato A, Jin M, Kee N, Lanio M, Tapia J, Quintana L, Muñoz Zamora A, Deng SX, Xu X, Landry DW, Denny CA Biological psychiatry 39389408 Biol Psychiatry 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/39389408
Behavioral and neurobiological effects of GnRH agonist treatment in mice-potential implications for puberty suppression in transgender individuals. Anacker C, Sydnor E, Chen BK, LaGamma CC, McGowan JC, Mastrodonato A, Hunsberger HC, Shores R, Dixon RS, McEwen BS, Byne W, Meyer-Bahlburg HFL, Bockting W, Ehrhardt AA, Denny CA Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 32919399 Neuropsychopharmacology 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/32919399
Traumatic Brain Injury-Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine. McGowan JC, Ladner LR, Shubeck CX, Tapia J, LaGamma CT, Anqueira-González A, DeFrancesco A, Chen BK, Hunsberger HC, Sydnor EJ, Logan RW, Yu TS, Kernie SG, Denny CA Biological psychiatry 37423591 Biol Psychiatry 2024 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/37423591
Social behavior in mice following chronic optogenetic stimulation of hippocampal engrams. Doucette E, Merfeld E, Leblanc H, Monasterio A, Cincotta C, Grella SL, Logan J, Ramirez S Neurobiology of learning and memory 33164892 Neurobiol Learn Mem 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33164892
Route-dependent spatial engram tagging in mouse dentate gyrus. Wilmerding LK, Kondratyev I, Ramirez S, Hasselmo ME Neurobiology of learning and memory 36822466 Neurobiol Learn Mem 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36822466
Editorial: Molecular and Cellular Underpinnings of Age-Related Memory Loss. Kosmidis S, Denny CA, Dranovsky A, Skoulakis EMC Frontiers in cell and developmental biology 34490280 Front Cell Dev Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34490280
Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights From (Female) Mice and (Wo)men. Hunsberger HC, Lee S, Jin M, Lanio M, Whye A, Cha J, Scarlata M, Matthews LC, Jayaseelan K, Denny CA, Alzheimer’s Disease Neuroimaging Initiative Biological psychiatry 39349155 Biol Psychiatry 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/39349155
Prophylactic (R,S)-Ketamine Is Effective Against Stress-Induced Behaviors in Adolescent but Not Aged Mice. Mastrodonato A, Pavlova I, Kee NC, Pham VA, McGowan JC, Mann JJ, Denny CA The international journal of neuropsychopharmacology 35229871 Int J Neuropsychopharmacol 2022 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/35229871
Weapons of stress reduction: (R,S)-ketamine and its metabolites as prophylactics for the prevention of stress-induced psychiatric disorders. Chen BK, Denny CA Neuropharmacology 36427554 Neuropharmacology 2023 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/36427554
Brain-wide immunolabeling and tissue clearing applications for engram research. Franceschini A, Jin M, Chen CW, Silvestri L, Mastrodonato A, Denny CA Neurobiology of learning and memory 39922482 Neurobiol Learn Mem 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39922482
A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis. Jin M, Ogundare SO, Lanio M, Sorid S, Whye AR, Leal Santos S, Franceschini A, Denny CA eLife 40709549 Elife 2025 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/40709549
A structural variation reference for medical and population genetics. Collins RL, Brand H, Karczewski KJ, Zhao X, Alföldi J, Francioli LC, Khera AV, Lowther C, Gauthier LD, Wang H, Watts NA, Solomonson M, O'Donnell-Luria A, Baumann A, Munshi R, Walker M, Whelan CW, Huang Y, Brookings T, Sharpe T, Stone MR, Valkanas E, Fu J, Tiao G, Laricchia KM, Ruano-Rubio V, Stevens C, Gupta N, Cusick C, Margolin L, Genome Aggregation Database Production Team, Genome Aggregation Database Consortium, Taylor KD, Lin HJ, Rich SS, Post WS, Chen YI, Rotter JI, Nusbaum C, Philippakis A, Lander E, Gabriel S, Neale BM, Kathiresan S, Daly MJ, Banks E, MacArthur DG, Talkowski ME Nature 32461652 Nature 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32461652
Paircounting. Nguyen HQ, Lee SD, Wu CT Trends in genetics : TIG 31521404 Trends Genet 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31521404
Three-dimensional genome organization via triplex-forming RNAs. Farabella I, Di Stefano M, Soler-Vila P, Marti-Marimon M, Marti-Renom MA Nature structural & molecular biology 34759378 Nat Struct Mol Biol 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34759378
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project. Dekker J, Alber F, Aufmkolk S, Beliveau BJ, Bruneau BG, Belmont AS, Bintu L, Boettiger A, Calandrelli R, Disteche CM, Gilbert DM, Gregor T, Hansen AS, Huang B, Huangfu D, Kalhor R, Leslie CS, Li W, Li Y, Ma J, Noble WS, Park PJ, Phillips-Cremins JE, Pollard KS, Rafelski SM, Ren B, Ruan Y, Shav-Tal Y, Shen Y, Shendure J, Shu X, Strambio-De-Castillia C, Vertii A, Zhang H, Zhong S Molecular cell 37419111 Mol Cell 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37419111
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution. Neguembor MV, Arcon JP, Buitrago D, Lema R, Walther J, Garate X, Martin L, Romero P, AlHaj Abed J, Gut M, Blanc J, Lakadamyali M, Wu CT, Brun Heath I, Orozco M, Dans PD, Cosma MP Nature structural & molecular biology 36220894 Nat Struct Mol Biol 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/36220894
Transcription-mediated supercoiling regulates genome folding and loop formation. Neguembor MV, Martin L, Castells-García Á, Gómez-García PA, Vicario C, Carnevali D, AlHaj Abed J, Granados A, Sebastian-Perez R, Sottile F, Solon J, Wu CT, Lakadamyali M, Cosma MP Molecular cell 34297911 Mol Cell 2021 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/34297911
Highly structured homolog pairing reflects functional organization of the Drosophila genome. AlHaj Abed J, Erceg J, Goloborodko A, Nguyen SC, McCole RB, Saylor W, Fudenberg G, Lajoie BR, Dekker J, Mirny LA, Wu CT Nature communications 31582763 Nat Commun 2019 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/31582763
Islands of retroelements are major components of Drosophila centromeres. Chang CH, Chavan A, Palladino J, Wei X, Martins NMC, Santinello B, Chen CC, Erceg J, Beliveau BJ, Wu CT, Larracuente AM, Mellone BG PLoS biology 31086362 PLoS Biol 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31086362
Deconwolf enables high-performance deconvolution of widefield fluorescence microscopy images. Wernersson E, Gelali E, Girelli G, Wang S, Castillo D, Mattsson Langseth C, Verron Q, Nguyen HQ, Chattoraj S, Martinez Casals A, Blom H, Lundberg E, Nilsson M, Marti-Renom MA, Wu CT, Crosetto N, Bienko M Nature methods 38844629 Nat Methods 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38844629
In Situ Super-Resolution Imaging of Genomic DNA with OligoSTORM and OligoDNA-PAINT. Beliveau BJ, Boettiger AN, Nir G, Bintu B, Yin P, Zhuang X, Wu CT Methods in molecular biology (Clifton, N.J.) 28924672 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28924672
Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. Lee YCG, Ogiyama Y, Martins NMC, Beliveau BJ, Acevedo D, Wu CT, Cavalli G, Karpen GH PLoS genetics 32203508 PLoS Genet 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32203508
Expectations and blind spots for structural variation detection from long-read assemblies and short-read genome sequencing technologies. Zhao X, Collins RL, Lee WP, Weber AM, Jun Y, Zhu Q, Weisburd B, Huang Y, Audano PA, Wang H, Walker M, Lowther C, Fu J, Human Genome Structural Variation Consortium, Gerstein MB, Devine SE, Marschall T, Korbel JO, Eichler EE, Chaisson MJP, Lee C, Mills RE, Brand H, Talkowski ME American journal of human genetics 33789087 Am J Hum Genet 2021 May 6 https://www.ncbi.nlm.nih.gov/pubmed/33789087
Ultraconserved Elements Occupy Specific Arenas of Three-Dimensional Mammalian Genome Organization. McCole RB, Erceg J, Saylor W, Wu CT Cell reports 29996107 Cell Rep 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29996107
The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos. Erceg J, AlHaj Abed J, Goloborodko A, Lajoie BR, Fudenberg G, Abdennur N, Imakaev M, McCole RB, Nguyen SC, Saylor W, Joyce EF, Senaratne TN, Hannan MA, Nir G, Dekker J, Mirny LA, Wu CT Nature communications 31582744 Nat Commun 2019 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/31582744
3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing. Nguyen HQ, Chattoraj S, Castillo D, Nguyen SC, Nir G, Lioutas A, Hershberg EA, Martins NMC, Reginato PL, Hannan M, Beliveau BJ, Church GM, Daugharthy ER, Marti-Renom MA, Wu CT Nature methods 32719531 Nat Methods 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32719531
Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling. Nir G, Farabella I, Pérez Estrada C, Ebeling CG, Beliveau BJ, Sasaki HM, Lee SD, Nguyen SC, McCole RB, Chattoraj S, Erceg J, AlHaj Abed J, Martins NMC, Nguyen HQ, Hannan MA, Russell S, Durand NC, Rao SSP, Kishi JY, Soler-Vila P, Di Pierro M, Onuchic JN, Callahan SP, Schreiner JM, Stuckey JA, Yin P, Aiden EL, Marti-Renom MA, Wu CT PLoS genetics 30586358 PLoS Genet 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30586358
A multiplexed DNA FISH strategy for assessing genome architecture in Caenorhabditis elegans. Fields BD, Nguyen SC, Nir G, Kennedy S eLife 31084706 Elife 2019 May 14 https://www.ncbi.nlm.nih.gov/pubmed/31084706
OligoMiner provides a rapid, flexible environment for the design of genome-scale oligonucleotide in situ hybridization probes. Beliveau BJ, Kishi JY, Nir G, Sasaki HM, Saka SK, Nguyen SC, Wu CT, Yin P Proceedings of the National Academy of Sciences of the United States of America 29463736 Proc Natl Acad Sci U S A 2018 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/29463736
Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. Fernandez TV, Leckman JF JAMA psychiatry 27706471 JAMA Psychiatry 2016 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/27706471
Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG Psychiatry research 31233935 Psychiatry Res 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31233935
An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz H, Dong J, Leckman JF Psychological medicine 32090720 Psychol Med 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/32090720
A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD. Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Aktan Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF Journal of attention disorders 27178060 J Atten Disord 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/27178060
Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome. Landeros-Weisenberger A, Mantovani A, Motlagh MG, de Alvarenga PG, Katsovich L, Leckman JF, Lisanby SH Brain stimulation 25912296 Brain Stimul 2015 May-Jun https://www.ncbi.nlm.nih.gov/pubmed/25912296
A preliminary study of movement intensity during a Go/No-Go task and its association with ADHD outcomes and symptom severity. Li F, Zheng Y, Smith SD, Shic F, Moore CC, Zheng X, Qi Y, Liu Z, Leckman JF Child and adolescent psychiatry and mental health 27999615 Child Adolesc Psychiatry Ment Health 2016 https://www.ncbi.nlm.nih.gov/pubmed/27999615
Meta-Analysis: Risk of Tics Associated With Psychostimulant Use in Randomized, Placebo-Controlled Trials. Cohen SC, Mulqueen JM, Ferracioli-Oda E, Stuckelman ZD, Coughlin CG, Leckman JF, Bloch MH Journal of the American Academy of Child and Adolescent Psychiatry 26299294 J Am Acad Child Adolesc Psychiatry 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26299294
Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function. Wexler BE, Kish R Psychiatry research 37494880 Psychiatry Res 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37494880
Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder. Morand-Beaulieu S, Smith SD, Ibrahim K, Wu J, Leckman JF, Crowley MJ, Sukhodolsky DG Cortex; a journal devoted to the study of the nervous system and behavior 35042055 Cortex 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35042055
N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial. Bloch MH, Panza KE, Yaffa A, Alvarenga PG, Jakubovski E, Mulqueen JM, Landeros-Weisenberger A, Leckman JF Journal of child and adolescent psychopharmacology 27027204 J Child Adolesc Psychopharmacol 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27027204
Urinary triclosan is associated with elevated body mass index in NHANES. Lankester J, Patel C, Cullen MR, Ley C, Parsonnet J PloS one 24278238 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24278238
Infectious diseases in children and body mass index in young adults. Suh G, Ley C, Parsonnet J Emerging infectious diseases 22932124 Emerg Infect Dis 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22932124
Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination. Tan SK, Granados AC, Bouquet J, Hoy-Schulz YE, Green L, Federman S, Stryke D, Haggerty TD, Ley C, Yeh MT, Jannat K, Maldonado YA, Andino R, Parsonnet J, Chiu CY Scientific reports 32958861 Sci Rep 2020 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/32958861
A modified Michaelis-Menten equation estimates growth from birth to 3 years in healthy babies in the US. Walters W, Ley C, Hastie T, Ley R, Parsonnet J Research square 36711501 Res Sq 2023 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/36711501
Triclosan and triclocarban exposure and thyroid function during pregnancy-A randomized intervention. Ley C, Pischel L, Parsonnet J Reproductive toxicology (Elmsford, N.Y.) 28939492 Reprod Toxicol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28939492
Household triclosan and triclocarban effects on the infant and maternal microbiome. Ribado JV, Ley C, Haggerty TD, Tkachenko E, Bhatt AS, Parsonnet J EMBO molecular medicine 29030459 EMBO Mol Med 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29030459
Shaping of infant B cell receptor repertoires by environmental factors and infectious disease. Nielsen SCA, Roskin KM, Jackson KJL, Joshi SA, Nejad P, Lee JY, Wagar LE, Pham TD, Hoh RA, Nguyen KD, Tsunemoto HY, Patel SB, Tibshirani R, Ley C, Davis MM, Parsonnet J, Boyd SD Science translational medicine 30814336 Sci Transl Med 2019 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/30814336
Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis. Pinto Y, Frishman S, Turjeman S, Eshel A, Nuriel-Ohayon M, Shrossel O, Ziv O, Walters W, Parsonnet J, Ley C, Johnson EL, Kumar K, Schweitzer R, Khatib S, Magzal F, Muller E, Tamir S, Tenenbaum-Gavish K, Rautava S, Salminen S, Isolauri E, Yariv O, Peled Y, Poran E, Pardo J, Chen R, Hod M, Borenstein E, Ley RE, Schwartz B, Louzoun Y, Hadar E, Koren O Gut 36627187 Gut 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36627187
Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children. Wagar LE, Bolen CR, Sigal N, Lopez Angel CJ, Guan L, Kirkpatrick BD, Haque R, Tibshirani RJ, Parsonnet J, Petri WA Jr, Davis MM Frontiers in immunology 31620139 Front Immunol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31620139
Recall accuracy of weekly automated surveys of health care utilization and infectious disease symptoms among infants over the first year of life. Ley C, Willis L, de la Luz Sanchez M, Parsonnet J PloS one 31846482 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/31846482
Influence of environmental exposures on T follicular helper cell function and implications on immunity: a comparison of Bangladeshi and American children. Van Fossen DM, Cho H, Wagar LE, Ma JZ, Parsonnet J, Haque R, Davis MM, Petri WA mBio 40062864 mBio 2025 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/40062864
Comparison of two methods - regression predictive model and intake shift model - for adjusting self-reported dietary recall of total energy intake of populations. Lankester J, Perry S, Parsonnet J Frontiers in public health 25506048 Front Public Health 2014 https://www.ncbi.nlm.nih.gov/pubmed/25506048
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Yang F, Nielsen SCA, Hoh RA, Röltgen K, Wirz OF, Haraguchi E, Jean GH, Lee JY, Pham TD, Jackson KJL, Roskin KM, Liu Y, Nguyen K, Ohgami RS, Osborne EM, Nadeau KC, Niemann CU, Parsonnet J, Boyd SD Science (New York, N.Y.) 33846272 Science 2021 May 14 https://www.ncbi.nlm.nih.gov/pubmed/33846272
Longitudinal comparison of the developing gut virome in infants and their mothers. Walters WA, Granados AC, Ley C, Federman S, Stryke D, Santos Y, Haggerty T, Sotomayor-Gonzalez A, Servellita V, Ley RE, Parsonnet J, Chiu CY Cell host & microbe 36758519 Cell Host Microbe 2023 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/36758519
Effect of long-term antibiotic use on weight in adolescents with acne. Contopoulos-Ioannidis DG, Ley C, Wang W, Ma T, Olson C, Shi X, Luft HS, Hastie T, Parsonnet J The Journal of antimicrobial chemotherapy 26782773 J Antimicrob Chemother 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26782773
Stanford's Outcomes Research in Kids (STORK): a prospective study of healthy pregnant women and their babies in Northern California. Ley C, Sanchez Mde L, Mathur A, Yang S, Sundaram V, Parsonnet J BMJ open 27075843 BMJ Open 2016 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/27075843
Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome. Poole AC, Pischel L, Ley C, Suh G, Goodrich JK, Haggerty TD, Ley RE, Parsonnet J mSphere 27303746 mSphere 2016 May-Jun https://www.ncbi.nlm.nih.gov/pubmed/27303746
A modified Michaelis-Menten equation estimates growth from birth to 3 years in healthy babies in the USA. Walters WA, Ley C, Hastie T, Ley RE, Parsonnet J BMC medical research methodology 38302887 BMC Med Res Methodol 2024 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/38302887
A multiplex extracellular interactome screening method employing high-avidity nanoparticles. Anaya MA, Wang ML, Gonzalez E, Lam AW, Vasnarungruengkul P, Vielmetter J, Wojtowicz WM, Zinn K bioRxiv : the preprint server for biology 40791403 bioRxiv 2025 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/40791403
Rapid discovery of new-to-nature protein domains by novelty-first forcing of language models. Subramanian A, Thomson M bioRxiv : the preprint server for biology 41256714 bioRxiv 2025 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/41256714
Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox. Siepe DH, Picton LK, Garcia KC ACS synthetic biology 37011906 ACS Synth Biol 2023 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/37011906
Benchmarking protein language models for protein crystallization. Mall R, Kaushik R, Martinez ZA, Thomson MW, Castiglione F Scientific reports 39827171 Sci Rep 2025 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/39827171
An Automated End-to-End Workflow for Production of Secreted Proteins in Transfected Mammalian Cells. Vasnarungruengkul P, Anaya MA, Lam AW, Gonzalez E, Zhang A, Wang ML, Wojtowicz WM, Zinn K, Vielmetter J bioRxiv : the preprint server for biology 40672302 bioRxiv 2025 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/40672302
TRILL: ORCHESTRATING MODULAR DEEP-LEARNING WORKFLOWS FOR DEMOCRATIZED, SCALABLE PROTEIN ANALYSIS AND ENGINEERING. Martinez ZA, Murray RM, Thomson MW bioRxiv : the preprint server for biology 37986952 bioRxiv 2023 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/37986952
Minimal gene set discovery in single-cell mRNA-seq datasets with ActiveSVM. Chen X, Chen S, Thomson M Nature computational science 38177588 Nat Comput Sci 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/38177588
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform. Siepe DH, Henneberg LT, Wilson SC, Hess GT, Bassik MC, Zinn K, Garcia KC eLife 36178190 Elife 2022 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/36178190
Pretrained protein language models choose between sequence novelty and structural completeness. Subramanian AM, Martinez ZA, Thomson M bioRxiv : the preprint server for biology 41256629 bioRxiv 2025 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/41256629
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors. Danneskiold-Samsøe NB, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ bioRxiv : the preprint server for biology 36993313 bioRxiv 2023 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/36993313
Protein CREATE enables closed-loop design of de novo synthetic protein binders. Lourenço A, Subramanian A, Spencer R, Anaya M, Miao J, Fu W, Chow E, Thomson M bioRxiv : the preprint server for biology 39803556 bioRxiv 2025 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/39803556
AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors. Banhos Danneskiold-Samsøe N, Kavi D, Jude KM, Nissen SB, Wat LW, Coassolo L, Zhao M, Santana-Oikawa GA, Broido BB, Garcia KC, Svensson KJ Cell systems 39541981 Cell Syst 2024 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/39541981
Spin glasses, error correcting codes, and synchronization of human stem cell organoids. Thomson M Cell 36736298 Cell 2023 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/36736298
D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response. Jiang J, Chen S, Tsou T, McGinnis CS, Khazaei T, Zhu Q, Park JH, Strazhnik IM, Vielmetter J, Gong Y, Hanna J, Chow ED, Sivak DA, Gartner ZJ, Thomson M bioRxiv : the preprint server for biology 37131803 bioRxiv 2025 May 23 https://www.ncbi.nlm.nih.gov/pubmed/37131803
Unexplored regions of the protein sequence-structure map revealed at scale by a library of foldtuned language models. Subramanian AM, Martinez ZA, Lourenço AL, Yuan SC, Liu S, Thomson M bioRxiv : the preprint server for biology 38187750 bioRxiv 2025 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/38187750
Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Yang A, Jude KM, Lai B, Minot M, Kocyla AM, Glassman CR, Nishimiya D, Kim YS, Reddy ST, Khan AA, Garcia KC Science (New York, N.Y.) 37499032 Science 2023 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/37499032
Structural ontogeny of protein-protein interactions. Yang A, Jiang H, Jude KM, Akpinaroglu D, Allenspach S, Li AJ, Bowden J, Perez CP, Liu L, Huang PS, Kortemme T, Listgarten J, Garcia KC Science (New York, N.Y.) 41678610 Science 2026 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/41678610
Selective axonal translation of the mRNA isoform encoding prenylated Cdc42 supports axon growth. Lee SJ, Zdradzinski MD, Sahoo PK, Kar AN, Patel P, Kawaguchi R, Aguilar BJ, Lantz KD, McCain CR, Coppola G, Lu Q, Twiss JL Journal of cell science 33674450 J Cell Sci 2021 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/33674450
KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration. Zdradzinski MD, Vaughn LS, Matoo S, Trumbull K, Smith TP, Noblitt D, Buchanan CN, Loomis A, Thames E, Lee SJ, Perrone-Bizzozero N, Lu Q, Larsen JM, Twiss JL PLoS genetics 41202098 PLoS Genet 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/41202098
Spatial and planar profiling of Rac1/Cdc42 signaling in Alzheimer's disease brain. Akhtar SN, Tran TD, Chen YH, Lu Q Journal of Alzheimer's disease : JAD 39610278 J Alzheimers Dis 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39610278
KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration. Zdradzinski MD, Vaughn LS, Matoo S, Trumbull K, Loomis A, Thames E, Lee SJ, Perrone-Bizzozero N, Lu Q, Larsen JM, Twiss JL bioRxiv : the preprint server for biology 39975228 bioRxiv 2025 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/39975228
Nanoarchitecture and molecular interactions of epithelial cell junction proteins revealed by super-resolution microscopy. Naser AN, Guiler W, Lu Q, Chen YH Annals of the New York Academy of Sciences 35819053 Ann N Y Acad Sci 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35819053
RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse Models. Nik Akhtar S, Lu Q Journal of Alzheimer's disease : JAD 37718806 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/37718806
Enabling systemic identification and functionality profiling for Cdc42 homeostatic modulators. Malasala S, Azimian F, Chen YH, Twiss JL, Boykin C, Akhtar SN, Lu Q Communications chemistry 39562759 Commun Chem 2024 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/39562759
TRPV4: En RhoA To a Cure? Lu Q, Chen YH BioEssays : news and reviews in molecular, cellular and developmental biology 35441721 Bioessays 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35441721
Trans-Compartmental Regulation of Tight Junction Barrier Function. Naser AN, Lu Q, Chen YH Tissue barriers 36220768 Tissue Barriers 2023 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/36220768
G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework. Zhang DF, Penwell T, Chen YH, Koehler A, Wu R, Nik Akhtar S, Lu Q The Journal of neuroscience : the official journal of the Society for Neuroscience 39327003 J Neurosci 2024 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/39327003
Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders. Nik Akhtar S, Bunner WP, Brennan E, Lu Q, Szatmari EM Frontiers in cellular neuroscience 36779014 Front Cell Neurosci 2023 https://www.ncbi.nlm.nih.gov/pubmed/36779014
Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA-NF-κB. Zhu Y, Howard GA, Pittman K, Boykin C, Herring LE, Wilkerson EM, Verbanac K, Lu Q Molecular cancer research : MCR 31189689 Mol Cancer Res 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31189689
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R Cell stem cell 33529599 Cell Stem Cell 2021 May 6 https://www.ncbi.nlm.nih.gov/pubmed/33529599
Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells. Jiang CL, Goyal Y, Jain N, Wang Q, Truitt RE, Coté AJ, Emert B, Mellis IA, Kiani K, Yang W, Jain R, Raj A Genome biology 35382863 Genome Biol 2022 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/35382863
Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids. Triandafillou CG, Sompalle P, Heyman Y, Raj A bioRxiv : the preprint server for biology 40766620 bioRxiv 2025 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/40766620
Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Arnett M, Yang W, Raj A Cell systems 38335955 Cell Syst 2024 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/38335955
AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance. Li J, Ravindran PT, O'Farrell A, Busch GT, Boe RH, Niu Z, Woo S, Dunagin MC, Jain N, Goyal Y, Sarma K, Herlyn M, Raj A bioRxiv : the preprint server for biology 39091739 bioRxiv 2024 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/39091739
Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Raj A bioRxiv : the preprint server for biology 36798299 bioRxiv 2023 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/36798299
Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states. Reffsin S, Miller J, Ayyanathan K, Dunagin MC, Jain N, Schultz DC, Cherry S, Raj A bioRxiv : the preprint server for biology 37461472 bioRxiv 2023 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/37461472
Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance. Boe RH, Triandafillou CG, Lazcano R, Wargo JA, Raj A bioRxiv : the preprint server for biology 39005406 bioRxiv 2024 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/39005406
ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ. Dardani I, Emert BL, Goyal Y, Jiang CL, Kaur A, Lee J, Rouhanifard SH, Alicea GM, Fane ME, Xiao M, Herlyn M, Weeraratna AT, Raj A Nature methods 36280724 Nat Methods 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36280724
Systematically quantifying morphological features reveals constraints on organoid phenotypes. Beck LE, Lee J, Coté C, Dunagin MC, Lukonin I, Salla N, Chang MK, Hughes AJ, Mornin JD, Gartner ZJ, Liberali P, Raj A Cell systems 35705097 Cell Syst 2022 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/35705097
Social reprogramming in ants induces longevity-associated glia remodeling. Sheng L, Shields EJ, Gospocic J, Glastad KM, Ratchasanmuang P, Berger SL, Raj A, Little S, Bonasio R Science advances 32875108 Sci Adv 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32875108
Picking Winners and Losers: Cell Competition in Tissue Development and Homeostasis. Kim W, Jain R Trends in genetics : TIG 32418713 Trends Genet 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32418713
FZD2 Regulates Murine Hair Follicle Function and Maintenance. Brennan-Crispi DM, Frankfurter M, Murphy C, Sheng E, Xu M, Morrisey EE, Millar SE, Leung TH The Journal of investigative dermatology 35051380 J Invest Dermatol 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35051380
Lineage memory shapes viral resistance barriers in human skin. Van Eyndhoven LC, Kinsler G, Zhang J, O'Farrell A, Abderrahim R, Srivastav A, Triandafillou CG, Greco TM, Zaret KS, Cristea IM, Orzalli MH, Drayman N, Singh A, Raj A bioRxiv : the preprint server for biology 40666908 bioRxiv 2025 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/40666908
Gastruloid patterning reflects division of labor among biased stem cell clones. Ayyappan V, Triandafillou CG, Sarma K, Raj A bioRxiv : the preprint server for biology 40791385 bioRxiv 2025 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/40791385
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells. Goyal Y, Busch GT, Pillai M, Li J, Boe RH, Grody EI, Chelvanambi M, Dardani IP, Emert B, Bodkin N, Braun J, Fingerman D, Kaur A, Jain N, Ravindran PT, Mellis IA, Kiani K, Alicea GM, Fane ME, Ahmed SS, Li H, Chen Y, Chai C, Kaster J, Witt RG, Lazcano R, Ingram DR, Johnson SB, Wani K, Dunagin MC, Lazar AJ, Weeraratna AT, Wargo JA, Herlyn M, Raj A Nature 37468627 Nature 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37468627
Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals. Sanford EM, Emert BL, Coté A, Raj A eLife 33284110 Elife 2020 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/33284110
Genetic screening for single-cell variability modulators driving therapy resistance. Torre EA, Arai E, Bayatpour S, Jiang CL, Beck LE, Emert BL, Shaffer SM, Mellis IA, Fane ME, Alicea GM, Budinich KA, Weeraratna AT, Shi J, Raj A Nature genetics 33398196 Nat Genet 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33398196
Variability within rare cell states enables multiple paths toward drug resistance. Emert BL, Cote CJ, Torre EA, Dardani IP, Jiang CL, Jain N, Shaffer SM, Raj A Nature biotechnology 33619394 Nat Biotechnol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33619394
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype. Shah PP, Keough KC, Gjoni K, Santini GT, Abdill RJ, Wickramasinghe NM, Dundes CE, Karnay A, Chen A, Salomon REA, Walsh PJ, Nguyen SC, Whalen S, Joyce EF, Loh KM, Dubois N, Pollard KS, Jain R Genome biology 36691074 Genome Biol 2023 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/36691074
Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations. Kiani K, Sanford EM, Goyal Y, Raj A Molecular systems biology 36069349 Mol Syst Biol 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36069349
Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Pérez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A Cell systems 34352221 Cell Syst 2021 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/34352221
Gene Networks with Transcriptional Bursting Recapitulate Rare Transient Coordinated High Expression States in Cancer. Schuh L, Saint-Antoine M, Sanford EM, Emert BL, Singh A, Marr C, Raj A, Goyal Y Cell systems 32325034 Cell Syst 2020 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/32325034
Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors. Shaffer SM, Emert BL, Reyes Hueros RA, Cote C, Harmange G, Schaff DL, Sizemore AE, Gupte R, Torre E, Singh A, Bassett DS, Raj A Cell 32735851 Cell 2020 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/32735851
Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks. Boe RH, Ayyappan V, Schuh L, Raj A Cell systems 36450286 Cell Syst 2022 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/36450286
Post-transcriptional splicing can occur in a slow-moving zone around the gene. Coté A, O'Farrell A, Dardani I, Dunagin M, Coté C, Wan Y, Bayatpour S, Drexler HL, Alexander KA, Chen F, Wassie AT, Patel R, Pham K, Boyden ES, Berger S, Phillips-Cremins J, Churchman LS, Raj A eLife 38577979 Elife 2024 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/38577979
Innate Immune Memory is Stimulus Specific. O'Farrell A, Niu Z, Li J, Van Eyndhoven LC, Sarma K, Raj A bioRxiv : the preprint server for biology 39896612 bioRxiv 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/39896612
Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles. Busch GT, Boe RH, Li J, Gruener RF, Arnett MJ, Ravindran PT, Herlyn M, Huang RS, Raj A bioRxiv : the preprint server for biology 40654745 bioRxiv 2025 May 6 https://www.ncbi.nlm.nih.gov/pubmed/40654745
A Nature-Inspired Ion Trap for Parallel Manipulation of Ions on a Massive Scale. Krutchinsky AN, Chait BT bioRxiv : the preprint server for biology 40909697 bioRxiv 2025 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/40909697
Structural characterization of a peptoid-inspired conformationally constrained oligomer (PICCO) bound to streptavidin. McEnaney P , Balzarini M , Park H , Kodadek T Chemical communications (Cambridge, England) 32785302 Chem Commun (Camb) 2020 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/32785302
Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11. Dickson P, Simanski S, Ngundu JM, Kodadek T Cell chemical biology 32857986 Cell Chem Biol 2020 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/32857986
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Dickson P, Abegg D, Vinogradova E, Takaya J, An H, Simanski S, Cravatt BF, Adibekian A, Kodadek T Cell chemical biology 32857985 Cell Chem Biol 2020 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/32857985
Reversible Assembly of Proteolysis Targeting Chimeras. Gui W, Giardina SF, Balzarini M, Barany F, Kodadek T ACS chemical biology 37422908 ACS Chem Biol 2023 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/37422908
Facile Synthesis of Homodimeric Protein Ligands. Gui W, Kodadek T Chembiochem : a European journal of chemical biology 37449865 Chembiochem 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37449865
Beyond protein binding: recent advances in screening DNA-encoded libraries. Kodadek T, Paciaroni NG, Balzarini M, Dickson P Chemical communications (Cambridge, England) 31633708 Chem Commun (Camb) 2019 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/31633708
Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy. Paciaroni NG , Ndungu JM , Kodadek T Chemical communications (Cambridge, England) 32215395 Chem Commun (Camb) 2020 Apr 30 https://www.ncbi.nlm.nih.gov/pubmed/32215395
Applications and Limitations of Oxime-Linked "Split PROTACs". Gui W, Kodadek T Chembiochem : a European journal of chemical biology 35802347 Chembiochem 2022 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/35802347
Synthesis and Screening of a DNA-Encoded Library of Non-Peptidic Macrocycles. Koesema E, Roy A, Paciaroni NG, Coito C, Tokmina-Roszyk M, Kodadek T Angewandte Chemie (International ed. in English) 35192245 Angew Chem Int Ed Engl 2022 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/35192245
Chemical composition of DNA-encoded libraries, past present and future. Dickson P, Kodadek T Organic & biomolecular chemistry 31017595 Org Biomol Chem 2019 May 15 https://www.ncbi.nlm.nih.gov/pubmed/31017595
Building better polymerases: Engineering the replication of expanded genetic alphabets. Ouaray Z, Benner SA, Georgiadis MM, Richards NGJ The Journal of biological chemistry 33004440 J Biol Chem 2020 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/33004440
Sequencing a DNA analog composed of artificial bases. Thomas CA, Brinkerhoff H, Craig JM, Hoshika S, Mihaylova D, Pfeffer AM, Franzi MC, Abell SJ, Carrasco JD, Gundlach JH, Benner SA, Laszlo AH Nature communications 40770181 Nat Commun 2025 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/40770181
Synthetic Biology Pathway to Nucleoside Triphosphates for Expanded Genetic Alphabets. Li Y, Abraham C, Suslov O, Yaren O, Shaw RW, Kim MJ, Wan S, Marliere P, Benner SA ACS synthetic biology 37227319 ACS Synth Biol 2023 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/37227319
A folding motif formed with an expanded genetic alphabet. Wang B, Rocca JR, Hoshika S, Chen C, Yang Z, Esmaeeli R, Wang J, Pan X, Lu J, Wang KK, Cao YC, Tan W, Benner SA Nature chemistry 38858518 Nat Chem 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38858518
Electrochemical Reduction and Oxidation of Eight Unnatural 2'-Deoxynucleosides at a Pyrolytic Graphite Electrode. Špaček J, Karalkar N, Fojta M, Wang J, Benner SA Electrochimica acta 33087943 Electrochim Acta 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/33087943
Ligand-Guided Selection with Artificially Expanded Genetic Information Systems against TCR-CD3ε. Zumrut H, Yang Z, Williams N, Arizala J, Batool S, Benner SA, Mallikaratchy P Biochemistry 31880917 Biochemistry 2020 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/31880917
Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide. Singh I, Laos R, Hoshika S, Benner SA, Georgiadis MM Nucleic acids research 29986111 Nucleic Acids Res 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/29986111
Enzymatic synthesis and nanopore sequencing of 12-letter supernumerary DNA. Kawabe H, Thomas CA, Hoshika S, Kim MJ, Kim MS, Miessner L, Kaplan N, Craig JM, Gundlach JH, Laszlo AH, Benner SA, Marchand JA Nature communications 37884513 Nat Commun 2023 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/37884513
Hachimoji DNA and RNA: A genetic system with eight building blocks. Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE Jr, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J Jr, Georgiadis MM, Benner SA Science (New York, N.Y.) 30792304 Science 2019 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/30792304
An Aptamer-Nanotrain Assembled from Six-Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells. Zhang L, Wang S, Yang Z, Hoshika S, Xie S, Li J, Chen X, Wan S, Li L, Benner SA, Tan W Angewandte Chemie (International ed. in English) 31650689 Angew Chem Int Ed Engl 2020 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/31650689
Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development. Wang B, Kobeissy F, Golpich M, Cai G, Li X, Abedi R, Haskins W, Tan W, Benner SA, Wang KKW Molecules (Basel, Switzerland) 38474636 Molecules 2024 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/38474636
Assessing Readability of an 8-Letter Expanded Deoxyribonucleic Acid Alphabet with Nanopores. Thomas CA, Craig JM, Hoshika S, Brinkerhoff H, Huang JR, Abell SJ, Kim HC, Franzi MC, Carrasco JD, Kim HJ, Smith DC, Gundlach JH, Benner SA, Laszlo AH Journal of the American Chemical Society 37036666 J Am Chem Soc 2023 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/37036666
Under the magnifying glass: The ups and downs of rDNA copy number. Kindelay SM, Maggert KA Seminars in cell & developmental biology 35595601 Semin Cell Dev Biol 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/35595601
Live analysis of position-effect variegation in Drosophila reveals different modes of action for HP1a and Su(var)3-9. Bughio FJ, Maggert KA Proceedings of the National Academy of Sciences of the United States of America 35704756 Proc Natl Acad Sci U S A 2022 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/35704756
Stress: An evolutionary mutagen. Maggert KA Proceedings of the National Academy of Sciences of the United States of America 31434787 Proc Natl Acad Sci U S A 2019 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/31434787
Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities. Bughio F, Huckell GR, Maggert KA Proceedings of the National Academy of Sciences of the United States of America 31527269 Proc Natl Acad Sci U S A 2019 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/31527269
Human rDNA copy number is unstable in metastatic breast cancers. Valori V, Tus K, Laukaitis C, Harris DT, LeBeau L, Maggert KA Epigenetics 31352858 Epigenetics 2020 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/31352858
The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance. Bughio F, Maggert KA Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 30511202 Chromosome Res 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30511202
The processivity factor Pol32 mediates nuclear localization of DNA polymerase delta and prevents chromosomal fragile site formation in Drosophila development. Ji J, Tang X, Hu W, Maggert KA, Rong YS PLoS genetics 31100062 PLoS Genet 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31100062
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L Cell 33333022 Cell 2020 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/33333022
Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: nothing but good news? Grant S, Lester HA The Journal of clinical investigation 33074245 J Clin Invest 2020 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/33074245
Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AEM, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, Looger LL, Gallagher T, Rees DC, Lester HA eLife 36520038 Elife 2022 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/36520038
Fluorescence Screens for Identifying Central Nervous System-Acting Drug-Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics. Beatty ZG, Muthusamy AK, Unger EK, Dougherty DA, Tian L, Looger LL, Shivange AV, Bera K, Lester HA, Nichols AL Bio-protocol 36532688 Bio Protoc 2022 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/36532688
Antidepressants enter cells, organelles, and membranes. Blumenfeld Z, Bera K, Castrén E, Lester HA Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 37783840 Neuropsychopharmacology 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37783840
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA Frontiers in cellular neuroscience 31798415 Front Cell Neurosci 2019 https://www.ncbi.nlm.nih.gov/pubmed/31798415
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids. Haloi N, Huang S, Nichols AL, Fine EJ, Friesenhahn NJ, Marotta CB, Dougherty DA, Lindahl E, Howard RJ, Mayo SL, Lester HA bioRxiv : the preprint server for biology 36712031 bioRxiv 2024 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/36712031
Chronic Menthol Does Not Change Stoichiometry or Functional Plasma Membrane Levels of Mouse α3β4-Containing Nicotinic Acetylcholine Receptors. Bavan S, Kim CH, Henderson BJ, Lester HA Molecular pharmacology 30670481 Mol Pharmacol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30670481
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids. Haloi N, Huang S, Nichols AL, Fine EJ, Friesenhahn NJ, Marotta CB, Dougherty DA, Lindahl E, Howard RJ, Mayo SL, Lester HA Protein engineering, design & selection : PEDS 38302088 Protein Eng Des Sel 2024 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/38302088
Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. Shivange AV, Borden PM, Muthusamy AK, Nichols AL, Bera K, Bao H, Bishara I, Jeon J, Mulcahy MJ, Cohen B, O'Riordan SL, Kim C, Dougherty DA, Chapman ER, Marvin JS, Looger LL, Lester HA The Journal of general physiology 30718376 J Gen Physiol 2019 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/30718376
Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins. Grant SN, Lester HA Biophysical journal 34197807 Biophys J 2021 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/34197807
Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids. Muthusamy AK, Kim CH, Virgil SC, Knox HJ, Marvin JS, Nichols AL, Cohen BN, Dougherty DA, Looger LL, Lester HA Journal of the American Chemical Society 35446570 J Am Chem Soc 2022 May 18 https://www.ncbi.nlm.nih.gov/pubmed/35446570
Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane. Nichols AL, Blumenfeld Z, Luebbert L, Knox HJ, Muthusamy AK, Marvin JS, Kim CH, Grant SN, Walton DP, Cohen BN, Hammar R, Looger L, Artursson P, Dougherty DA, Lester HA The Journal of neuroscience : the official journal of the Society for Neuroscience 36868853 J Neurosci 2023 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/36868853
Continuous Nicotine Monitors for Personal Nicotine Pharmacokinetics: A Receptor-Aware Research Agenda. Nichols AL, Marotta CB, Lukas H, Friesenhahn NJ, Wagenaar DA, Mayo SL, Dougherty DA, Benowitz NL, Gao W, Muthusamy AK, Lester HA Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 40079271 Nicotine Tob Res 2025 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/40079271
Coevolution-based inference of amino acid interactions underlying protein function. Salinas VH, Ranganathan R eLife 30024376 Elife 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/30024376
Deconstruction of the Ras switching cycle through saturation mutagenesis. Bandaru P, Shah NH, Bhattacharyya M, Barton JP, Kondo Y, Cofsky JC, Gee CL, Chakraborty AK, Kortemme T, Ranganathan R, Kuriyan J eLife 28686159 Elife 2017 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/28686159
Roadmap on biology in time varying environments. Murugan A, Husain K, Rust MJ, Hepler C, Bass J, Pietsch JMJ, Swain PS, Jena SG, Toettcher JE, Chakraborty AK, Sprenger KG, Mora T, Walczak AM, Rivoire O, Wang S, Wood KB, Skanata A, Kussell E, Ranganathan R, Shih HY, Goldenfeld N Physical biology 33477124 Phys Biol 2021 May 17 https://www.ncbi.nlm.nih.gov/pubmed/33477124
A Novel EGFRvIII T-Cell Bispecific Antibody for the Treatment of Glioblastoma. Iurlaro R, Waldhauer I, Planas-Rigol E, Bonfill-Teixidor E, Arias A, Nicolini V, Freimoser-Grundschober A, Cuartas I, Martínez-Moreno A, Martínez-Ricarte F, Cordero E, Cicuendez M, Casalino S, Guardia-Reyes X, Fahrni L, Pöschinger T, Steinhart V, Richard M, Briner S, Mueller J, Osl F, Sam J, Colombetti S, Bacac M, Klein C, Pineda E, Reyes-Figueroa L, Di Somma A, González J, Nuciforo P, Carles J, Vieito M, Tabernero J, Umaña P, Seoane J Molecular cancer therapeutics 35915983 Mol Cancer Ther 2022 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/35915983
Three structural solutions for bacterial adhesion pilus stability and superelasticity. Doran MH, Baker JL, Dahlberg T, Andersson M, Bullitt E Structure (London, England : 1993) 37001523 Structure 2023 May 4 https://www.ncbi.nlm.nih.gov/pubmed/37001523
Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Uys JD, McGuier NS, Gass JT, Griffin WC 3rd, Ball LE, Mulholland PJ Addiction biology 25787124 Addict Biol 2016 May https://www.ncbi.nlm.nih.gov/pubmed/25787124
A set of experimentally validated, mutually orthogonal primers for combinatorially specifying genetic components. Subramanian SK, Russ WP, Ranganathan R Synthetic biology (Oxford, England) 32995509 Synth Biol (Oxf) 2018 https://www.ncbi.nlm.nih.gov/pubmed/32995509
Direct visualization of electric-field-stimulated ion conduction in a potassium channel. Lee B, White KI, Socolich M, Klureza MA, Henning R, Srajer V, Ranganathan R, Hekstra DR Cell 39793560 Cell 2025 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/39793560
Electric-field-stimulated protein mechanics. Hekstra DR, White KI, Socolich MA, Henning RW, Šrajer V, Ranganathan R Nature 27926732 Nature 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27926732
An evolution-based model for designing chorismate mutase enzymes. Russ WP, Figliuzzi M, Stocker C, Barrat-Charlaix P, Socolich M, Kast P, Hilvert D, Monasson R, Cocco S, Weigt M, Ranganathan R Science (New York, N.Y.) 32703877 Science 2020 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/32703877
RNA sectors and allosteric function within the ribosome. Walker AS, Russ WP, Ranganathan R, Schepartz A Proceedings of the National Academy of Sciences of the United States of America 32747536 Proc Natl Acad Sci U S A 2020 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/32747536
Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles. Kaisanlahti A, Turunen J, Byts N, Samoylenko A, Bart G, Virtanen N, Tejesvi MV, Zhyvolozhnyi A, Sarfraz S, Kumpula S, Hekkala J, Salmi S, Will O, Korvala J, Paalanne N, Erawijantari PP, Suokas M, Medina TP, Vainio S, Medina OP, Lahti L, Tapiainen T, Reunanen J Microbiome 37953319 Microbiome 2023 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/37953319
Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction. Burge RA, Bialousow L, McFall T, Bamonte L, Johnson G, Smith M, Vaena SG, Comte-Walters S, Ball LE, Berto S, O'Bryan JP, Hobbs GA Cancer research communications 40951926 Cancer Res Commun 2025 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/40951926
Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function. Rynda-Apple A, Dobrinen E, McAlpine M, Read A, Harmsen A, Richert LE, Calverley M, Pallister K, Voyich J, Wiley JA, Johnson B, Young M, Douglas T, Harmsen AG The American journal of pathology 22642909 Am J Pathol 2012 Jul https://www.ncbi.nlm.nih.gov/pubmed/22642909
Learning the pattern of epistasis linking genotype and phenotype in a protein. Poelwijk FJ, Socolich M, Ranganathan R Nature communications 31527666 Nat Commun 2019 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/31527666
An evolutionary hotspot defines functional differences between CRYPTOCHROMES. Rosensweig C, Reynolds KA, Gao P, Laothamatas I, Shan Y, Ranganathan R, Takahashi JS, Green CB Nature communications 29556064 Nat Commun 2018 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/29556064
Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation. Muller MP, Jiang T, Sun C, Lihan M, Pant S, Mahinthichaichan P, Trifan A, Tajkhorshid E Chemical reviews 30978005 Chem Rev 2019 May 8 https://www.ncbi.nlm.nih.gov/pubmed/30978005
Exact distance measurements for structure and dynamics in solid proteins by fast-magic-angle-spinning NMR. Grohe K, Nimerovsky E, Singh H, Vasa SK, Söldner B, Vögeli B, Rienstra CM, Linser R Chemical communications (Cambridge, England) 31199417 Chem Commun (Camb) 2019 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/31199417
Microscopic view of lipids and their diverse biological functions. Wen PC, Mahinthichaichan P, Trebesch N, Jiang T, Zhao Z, Shinn E, Wang Y, Shekhar M, Kapoor K, Chan CK, Tajkhorshid E Current opinion in structural biology 30048836 Curr Opin Struct Biol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30048836
Solid-State NMR of highly (13)C-enriched cholesterol in lipid bilayers. Della Ripa LA, Petros ZA, Cioffi AG, Piehl DW, Courtney JM, Burke MD, Rienstra CM Methods (San Diego, Calif.) 29366688 Methods 2018 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/29366688
Mechanism of gating and partial agonist action in the glycine receptor. Yu J, Zhu H, Lape R, Greiner T, Du J, Lü W, Sivilotti L, Gouaux E Cell 33567265 Cell 2021 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/33567265
Interaction of Alpha-Synuclein and Its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature. McClain SM, Ojoawo AM, Lin W, Rienstra CM, Murphy CJ ACS nano 32672441 ACS Nano 2020 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/32672441
Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A Developmental cell 32109384 Dev Cell 2020 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/32109384
Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy. Zhang J, Kim EC, Chen C, Procko E, Pant S, Lam K, Patel J, Choi R, Hong M, Joshi D, Bolton E, Tajkhorshid E, Chung HJ Scientific reports 32179837 Sci Rep 2020 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/32179837
Multivalent Polymer-Peptide Conjugates-A General Platform for Inhibiting Amyloid Beta Peptide Aggregation. Jiang X, Halmes AJ, Licari G, Smith JW, Song Y, Moore EG, Chen Q, Tajkhorshid E, Rienstra CM, Moore JS ACS macro letters 32149017 ACS Macro Lett 2019 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/32149017
Computational Dissection of Membrane Transport at a Microscopic Level. Jiang T, Wen PC, Trebesch N, Zhao Z, Pant S, Kapoor K, Shekhar M, Tajkhorshid E Trends in biochemical sciences 31813734 Trends Biochem Sci 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31813734
Membrane Interactions of Cy3 and Cy5 Fluorophores and Their Effects on Membrane-Protein Dynamics. Lam K, Tajkhorshid E Biophysical journal 32533943 Biophys J 2020 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/32533943
Integrating hydrogen-deuterium exchange mass spectrometry with molecular dynamics simulations to probe lipid-modulated conformational changes in membrane proteins. Martens C, Shekhar M, Lau AM, Tajkhorshid E, Politis A Nature protocols 31605097 Nat Protoc 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31605097
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Rasouli A, Yu Q, Dehghani-Ghahnaviyeh S, Wen PC, Kowal J, Locher KP, Tajkhorshid E Proceedings of the National Academy of Sciences of the United States of America 36580587 Proc Natl Acad Sci U S A 2023 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/36580587
Active participation of membrane lipids in inhibition of multidrug transporter P-glycoprotein. Kapoor K, Pant S, Tajkhorshid E Chemical science 34084427 Chem Sci 2021 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/34084427
Backbone amides are determinants of Cl(-) selectivity in CLC ion channels. Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A Nature communications 36473856 Nat Commun 2022 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/36473856
Membrane Mixer: A Toolkit for Efficient Shuffling of Lipids in Heterogeneous Biological Membranes. Licari G, Dehghani-Ghahnaviyeh S, Tajkhorshid E Journal of chemical information and modeling 35104125 J Chem Inf Model 2022 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/35104125
An Orchestrated Interaction Network at the Binding Site of Human SERT Enables the Serotonin Occlusion and Import. Zhao Z, Wen PC, Tajkhorshid E Biochemistry 40722230 Biochemistry 2025 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/40722230
Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter. Kinz-Thompson CD, Lopez-Redondo ML, Mulligan C, Sauer DB, Marden JJ, Song J, Tajkhorshid E, Hunt JF, Stokes DL, Mindell JA, Wang DN, Gonzalez RL Jr Proceedings of the National Academy of Sciences of the United States of America 41490488 Proc Natl Acad Sci U S A 2026 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/41490488
Lactadherin's Multistate Binding Predicts Stable Membrane-Bound Conformations of Factors V and VIII's C Domains. Cheng KJ, De Lio AM, Jain R, Paul D, Morrissey JH, Pogorelov TV Biochemistry 37747791 Biochemistry 2023 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/37747791
Tumor-acquired somatic mutation affects conformation to abolish ABCG2-mediated drug resistance. Gose T, Rasouli A, Dehghani-Ghahnaviyeh S, Wen PC, Wang Y, Lynch J, Fukuda Y, Shafi T, Ford RC, Tajkhorshid E, Schuetz JD Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 38387283 Drug Resist Updat 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38387283
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD Nature 37938782 Nature 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37938782
APACE: AlphaFold2 and advanced computing as a service for accelerated discovery in biophysics. Park H, Patel P, Haas R, Huerta EA Proceedings of the National Academy of Sciences of the United States of America 38913887 Proc Natl Acad Sci U S A 2024 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/38913887
Automated fibril structure calculations in Xplor-NIH. Barclay AM, Milchberg MH, Warmuth OA, Tuttle MD, Dennis CJ, Schwieters CD, Rienstra CM Structure (London, England : 1993) 39662464 Structure 2025 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/39662464
Conformational free energy landscape of a glutamate transporter and microscopic details of its transport mechanism. Thangapandian S, Fakharzadeh A, Moradi M, Tajkhorshid E Proceedings of the National Academy of Sciences of the United States of America 40042900 Proc Natl Acad Sci U S A 2025 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/40042900
Probing Solution Dynamics of Tissue Factor Using Molecular Dynamics Simulations Guided by NMR Chemical Shifts. Lihan M, Pant S, Ojoawo AM, Rienstra CM, Tajkhorshid E The journal of physical chemistry. B 41894586 J Phys Chem B 2026 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/41894586
Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage. Ciudad S, Puig E, Botzanowski T, Meigooni M, Arango AS, Do J, Mayzel M, Bayoumi M, Chaignepain S, Maglia G, Cianferani S, Orekhov V, Tajkhorshid E, Bardiaux B, Carulla N Nature communications 32541820 Nat Commun 2020 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/32541820
Polymer-Peptide Conjugates Convert Amyloid into Protein Nanobundles through Fragmentation and Lateral Association. Smith JW, Jiang X, An H, Barclay AM, Licari G, Tajkhorshid E, Moore EG, Rienstra CM, Moore JS, Chen Q ACS applied nano materials 32149271 ACS Appl Nano Mater 2020 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/32149271
Molecular mechanism of prestin electromotive signal amplification. Ge J, Elferich J, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E Cell 34390643 Cell 2021 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/34390643
Microscopic Characterization of GRP1 PH Domain Interaction with Anionic Membranes. Pant S, Tajkhorshid E Journal of computational chemistry 31762060 J Comput Chem 2020 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/31762060
Probing cholesterol binding and translocation in P-glycoprotein. Thangapandian S, Kapoor K, Tajkhorshid E Biochimica et biophysica acta. Biomembranes 31676371 Biochim Biophys Acta Biomembr 2020 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/31676371
Structural basis for the reaction cycle of DASS dicarboxylate transporters. Sauer DB, Trebesch N, Marden JJ, Cocco N, Song J, Koide A, Koide S, Tajkhorshid E, Wang DN eLife 32869741 Elife 2020 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/32869741
Twisting and tilting of a mechanosensitive molecular probe detects order in membranes. Licari G, Strakova K, Matile S, Tajkhorshid E Chemical science 32864081 Chem Sci 2020 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/32864081
Probing key elements of teixobactin-lipid II interactions in membranes. Wen PC, Vanegas JM, Rempe SB, Tajkhorshid E Chemical science 30210775 Chem Sci 2018 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/30210775
Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase. Jiang T, Yu K, Hartzell HC, Tajkhorshid E eLife 28917060 Elife 2017 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/28917060
Lipid specificity of the membrane binding domain of coagulation factor X. Muller MP, Wang Y, Morrissey JH, Tajkhorshid E Journal of thrombosis and haemostasis : JTH 28782177 J Thromb Haemost 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28782177
(31)P-dephased, (13)C-detected REDOR for NMR crystallography at natural isotopic abundance. Greenwood AI, Clay MC, Rienstra CM Journal of magnetic resonance (San Diego, Calif. : 1997) 28319851 J Magn Reson 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28319851
PIP(2)-dependent coupling of voltage sensor and pore domains in K(v)7.2 channel. Pant S, Zhang J, Kim EC, Lam K, Chung HJ, Tajkhorshid E Communications biology 34650221 Commun Biol 2021 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/34650221
Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes. Gullett JM, Cuypers MG, Grace CR, Pant S, Subramanian C, Tajkhorshid E, Rock CO, White SW The Journal of biological chemistry 35122790 J Biol Chem 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35122790
Targeting lipid-protein interaction to treat Syk-mediated acute myeloid leukemia. Singaram I, Sharma A, Pant S, Lihan M, Park MJ, Pergande M, Buwaneka P, Hu Y, Mahmud N, Kim YM, Cologna S, Gevorgyan V, Khan I, Tajkhorshid E, Cho W Nature chemical biology 36229686 Nat Chem Biol 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36229686
Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1. Zhang Y, Soubias O, Pant S, Heinrich F, Vogel A, Li J, Li Y, Clifton LA, Daum S, Bacia K, Huster D, Randazzo PA, Lösche M, Tajkhorshid E, Byrd RA Nature communications 37989735 Nat Commun 2023 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/37989735
Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS Nature communications 37938578 Nat Commun 2023 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/37938578
Topological Learning Approach to Characterizing Biological Membranes. Arango AS, Park H, Tajkhorshid E bioRxiv : the preprint server for biology 38076911 bioRxiv 2023 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/38076911
Enhancing Spectrometer Performance with Unsupervised Machine Learning. Harding BD, Hu Z, Hiett A, Delaglio F, Henzler-Wildman KA, Rienstra CM The journal of physical chemistry. B 39395040 J Phys Chem B 2024 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/39395040
Top-Down Scoring of Spectral Fitness by Image Analysis for Protein Structure Validation. Harding BD, DeZonia B, Garg R, Hu Z, Delaglio F, Grant T, Rienstra CM Journal of chemical information and modeling 41417269 J Chem Inf Model 2026 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/41417269
An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells. Yadav AK, Reinhardt CJ, Arango AS, Huff HC, Dong L, Malkowski MG, Das A, Tajkhorshid E, Chan J Angewandte Chemie (International ed. in English) 31854058 Angew Chem Int Ed Engl 2020 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/31854058
Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Coleman JA, Yang D, Zhao Z, Wen PC, Yoshioka C, Tajkhorshid E, Gouaux E Nature 31019304 Nature 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31019304
Structural Insights into the Lipid A Transport Pathway in MsbA. Padayatti PS, Lee SC, Stanfield RL, Wen PC, Tajkhorshid E, Wilson IA, Zhang Q Structure (London, England : 1993) 31130486 Structure 2019 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/31130486
(1)H-Detected REDOR with Fast Magic-Angle Spinning of a Deuterated Protein. Ghosh M, Rienstra CM The journal of physical chemistry. B 28816462 J Phys Chem B 2017 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/28816462
A modification of γ-encoded RN symmetry pulses for increasing the scaling factor and more accurate measurements of the strong heteronuclear dipolar couplings. Nimerovsky E, Soutar CP Journal of magnetic resonance (San Diego, Calif. : 1997) 32950918 J Magn Reson 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32950918
The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer. Radka CD, Grace CR, Hasdemir HS, Li Y, Rodriguez CC, Rodrigues P, Oldham ML, Qayyum MZ, Pitre A, MacCain WJ, Kalathur RC, Tajkhorshid E, Rock CO The Journal of biological chemistry 38211817 J Biol Chem 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38211817
A serine loop in tissue factor mediates substrate selectivity by the tissue factor-factor VIIa complex. Birkle F, Morrissey JH Journal of thrombosis and haemostasis : JTH 32885882 J Thromb Haemost 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32885882
Binding mode of SARS-CoV-2 fusion peptide to human cellular membrane. Gorgun D, Lihan M, Kapoor K, Tajkhorshid E Biophysical journal 33675757 Biophys J 2021 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/33675757
Stoichiometric analysis reveals a unique phosphatidylserine binding site in coagulation factor X. Paul D, Morrissey JH Journal of thrombosis and haemostasis : JTH 34894064 J Thromb Haemost 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34894064
Molecular View into Preferential Binding of the Factor VII Gla Domain to Phosphatidic Acid. Muller MP, Morrissey JH, Tajkhorshid E Biochemistry 35853076 Biochemistry 2022 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/35853076
Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes. Lewandowska A, Soutar CP, Greenwood AI, Nimerovsky E, De Lio AM, Holler JT, Hisao GS, Khandelwal A, Zhang J, SantaMaria AM, Schwieters CD, Pogorelov TV, Burke MD, Rienstra CM Nature structural & molecular biology 34887566 Nat Struct Mol Biol 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34887566
Tuning phenylalanine fluorination to assess aromatic contributions to protein function and stability in cells. Galles GD, Infield DT, Clark CJ, Hemshorn ML, Manikandan S, Fazan F, Rasouli A, Tajkhorshid E, Galpin JD, Cooley RB, Mehl RA, Ahern CA Nature communications 36599844 Nat Commun 2023 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/36599844
Structures of the TMC-1 complex illuminate mechanosensory transduction. Jeong H, Clark S, Goehring A, Dehghani-Ghahnaviyeh S, Rasouli A, Tajkhorshid E, Gouaux E Nature 36224384 Nature 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/36224384
Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms. Le LTM, Thompson JR, Dehghani-Ghahnaviyeh S, Pant S, Dang PX, French JB, Kanikeyo T, Tajkhorshid E, Alam A The EMBO journal 36484366 EMBO J 2023 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/36484366
Cross polarization stability in multidimensional NMR spectroscopy of biological solids. Harding BD, Barclay AM, Piehl DW, Hiett A, Warmuth OA, Han R, Henzler-Wildman K, Rienstra CM Journal of magnetic resonance (San Diego, Calif. : 1997) 38991266 J Magn Reson 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38991266
Charge, Hydrophobicity, and Lipid Type Drive Antimicrobial Peptides' Unique Perturbation Ensembles. Cheng KJ, Shastry S, Campolargo JD, Hallock MJ, Pogorelov TV Biochemistry 40105792 Biochemistry 2025 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/40105792
Direct protein-lipid interactions shape the conformational landscape of secondary transporters. Martens C, Shekhar M, Borysik AJ, Lau AM, Reading E, Tajkhorshid E, Booth PJ, Politis A Nature communications 30297844 Nat Commun 2018 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/30297844
Structure of the alternative complex III in a supercomplex with cytochrome oxidase. Sun C, Benlekbir S, Venkatakrishnan P, Wang Y, Hong S, Hosler J, Tajkhorshid E, Rubinstein JL, Gennis RB Nature 29695868 Nature 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29695868
Calcium-Induced Lipid Nanocluster Structures: Sculpturing of the Plasma Membrane. Hallock MJ, Greenwood AI, Wang Y, Morrissey JH, Tajkhorshid E, Rienstra CM, Pogorelov TV Biochemistry 30456950 Biochemistry 2018 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/30456950
Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer. Kumar P, Wang Y, Zhang Z, Zhao Z, Cymes GD, Tajkhorshid E, Grosman C Proceedings of the National Academy of Sciences of the United States of America 31911476 Proc Natl Acad Sci U S A 2020 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/31911476
Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation. Haley HMS, Hill AG, Greenwood AI, Woerly EM, Rienstra CM, Burke MD Journal of the American Chemical Society 30388000 J Am Chem Soc 2018 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/30388000
A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca(2+)-activated Cl(-) channel ANO1 (TMEM16A). Yu K, Jiang T, Cui Y, Tajkhorshid E, Hartzell HC Proceedings of the National Academy of Sciences of the United States of America 31515451 Proc Natl Acad Sci U S A 2019 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/31515451
Relationship among egg quality traits in Japanese quails and prediction of egg weight and color using data mining algorithms. Çelik Ş, Eyduran E, Şengül AY, Şengül T Tropical animal health and production 34195902 Trop Anim Health Prod 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/34195902
Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function. Wu Q, Akhter A, Pant S, Cho E, Zhu JX, Garner A, Ohyama T, Tajkhorshid E, van Meyel DJ, Ryan RM The Journal of clinical investigation 35167492 J Clin Invest 2022 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/35167492
Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1. Soubias O, Pant S, Heinrich F, Zhang Y, Roy NS, Li J, Jian X, Yohe ME, Randazzo PA, Lösche M, Tajkhorshid E, Byrd RA Science advances 32998886 Sci Adv 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32998886
Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter. Jia R, Martens C, Shekhar M, Pant S, Pellowe GA, Lau AM, Findlay HE, Harris NJ, Tajkhorshid E, Booth PJ, Politis A Nature communications 33268777 Nat Commun 2020 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/33268777
Conformational changes in the nucleotide-binding domains of P-glycoprotein induced by ATP hydrolysis. Dehghani-Ghahnaviyeh S, Kapoor K, Tajkhorshid E FEBS letters 33159693 FEBS Lett 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33159693
A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain. Light TP, Gomez-Soler M, Wang Z, Karl K, Zapata-Mercado E, Gehring MP, Lechtenberg BC, Pogorelov TV, Hristova K, Pasquale EB The Journal of biological chemistry 34139238 J Biol Chem 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34139238
Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X. Muller MP, Mortenson A, Sedzro JC, Wen PC, Morrissey JH, Tajkhorshid E Blood advances 39671302 Blood Adv 2025 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/39671302
Atomistic characterization of β2-glycoprotein I domain V interaction with anionic membranes. Hasdemir HS, Pozzi N, Tajkhorshid E Journal of thrombosis and haemostasis : JTH 39047943 J Thromb Haemost 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39047943
Cholesterol-targeting Wnt-β-catenin signaling inhibitors for colorectal cancer. Sharma A, Zalejski J, Bendre SV, Kavrokova S, Hasdemir HS, Ozgulbas DG, Sun J, Pathmasiri KC, Shi R, Aloulou A, Berkley K, Delisle CF, Wang Y, Weisser E, Buweneka P, Pierre-Jacques D, Mukherjee S, Abbasi DA, Lee D, Wang B, Gevorgyan V, Cologna SM, Tajkhorshid E, Nelson ER, Cho W Nature chemical biology 40240631 Nat Chem Biol 2025 Sep https://www.ncbi.nlm.nih.gov/pubmed/40240631
Topological Learning Approach to Characterizing Biological Membranes. Arango AS, Park H, Tajkhorshid E Journal of chemical information and modeling 38912752 J Chem Inf Model 2024 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/38912752
Solid-State NMR (13)C sensitivity at high magnetic field. Han R, Borcik CG, Wang S, Warmuth OA, Geohring K, Mullen C, Incitti M, Stringer JA, Rienstra CM Journal of magnetic resonance (San Diego, Calif. : 1997) 38991265 J Magn Reson 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38991265
Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease. Hajeyah AA, Protty MB, Paul D, Costa D, Omidvar N, Morgan B, Iwasaki Y, McGill B, Jenkins PV, Yousef Z, Allen-Redpath K, Soyama S, Choudhury A, Mitra R, Yaqoob P, Morrissey JH, Collins PW, O'Donnell VB Journal of lipid research 38103786 J Lipid Res 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38103786
Improved Highly Mobile Membrane Mimetic Model for Investigating Protein-Cholesterol Interactions. Lihan M, Tajkhorshid E Journal of chemical information and modeling 38844760 J Chem Inf Model 2024 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/38844760
Probing the role of membrane in neutralizing activity of antibodies against influenza virus. Ozgulbas DG, Tan TJC, Wen PC, Teo QW, Lv H, Ghaemi Z, Frank M, Wu NC, Tajkhorshid E Structure (London, England : 1993) 41421345 Structure 2026 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/41421345
High prevalence of clonal monoallelic expression. Vigneau S, Vinogradova S, Savova V, Gimelbrant A Nature genetics 30082785 Nat Genet 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30082785
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R Cell 29456084 Cell 2018 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/29456084
Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas. Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R Proceedings of the National Academy of Sciences of the United States of America 29599125 Proc Natl Acad Sci U S A 2018 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/29599125
RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes. Gupta S, Lafontaine DL, Vigneau S, Mendelevich A, Vinogradova S, Igarashi KJ, Bortvin A, Alves-Pereira CF, Nag A, Gimelbrant AA G3 (Bethesda, Md.) 35100361 G3 (Bethesda) 2022 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/35100361
Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale. Mendelevich A, Gupta S, Pakharev A, Teodosiadis A, Mironov AA, Gimelbrant AA bioRxiv : the preprint server for biology 36798258 bioRxiv 2023 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/36798258
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I eLife 41037321 Elife 2025 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/41037321
Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, Sullivan TJ, Hess JM, Gimelbrant AA, Beroukhim R, Lawrence MS, Getz G, Lane AA Nature genetics 27869828 Nat Genet 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27869828
Risk alleles of genes with monoallelic expression are enriched in gain-of-function variants and depleted in loss-of-function variants for neurodevelopmental disorders. Savova V, Vinogradova S, Pruss D, Gimelbrant AA, Weiss LA Molecular psychiatry 28265118 Mol Psychiatry 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28265118
Editing DNA Methylation in the Mammalian Genome. Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna S, Shu J, Dadon D, Young RA, Jaenisch R Cell 27662091 Cell 2016 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/27662091
Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale. Mendelevich A, Gupta S, Pakharev A, Teodosiadis A, Mironov AA, Gimelbrant AA Bioinformatics (Oxford, England) 37387154 Bioinformatics 2023 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/37387154
Replicate sequencing libraries are important for quantification of allelic imbalance. Mendelevich A, Vinogradova S, Gupta S, Mironov AA, Sunyaev SR, Gimelbrant AA Nature communications 34099647 Nat Commun 2021 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/34099647
dbMAE: the database of autosomal monoallelic expression. Savova V, Patsenker J, Vigneau S, Gimelbrant AA Nucleic acids research 26503248 Nucleic Acids Res 2016 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/26503248
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA Nature genetics 26808112 Nat Genet 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26808112
Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Song Y, van den Berg PR, Markoulaki S, Soldner F, Dall'Agnese A, Henninger JE, Drotar J, Rosenau N, Cohen MA, Young RA, Semrau S, Stelzer Y, Jaenisch R Molecular cell 31422875 Mol Cell 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/31422875
Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility. Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseev Y, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I bioRxiv : the preprint server for biology 38496444 bioRxiv 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/38496444
Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages. Yabaji SM, Rukhlenko OS, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, Kholodenko BN, Gimelbrant AA, Kramnik I Science advances 37756395 Sci Adv 2023 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/37756395
Value-Based Standards Guide Sexism Inferences for Self and Others. Mitamura C, Erickson L, Devine PG Journal of experimental social psychology 29230069 J Exp Soc Psychol 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/29230069
Laughter and the Management of Divergent Positions in Peer Review Interactions. Raclaw J, Ford CE Journal of pragmatics 29170594 J Pragmat 2017 May https://www.ncbi.nlm.nih.gov/pubmed/29170594
Women Are Less Likely Than Men to Be Full Professors in Cardiology: Why Does This Happen and How Can We Fix It? Carnes M, Bairey Merz CN Circulation 28153988 Circulation 2017 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/28153988
Inferences About Sexual Orientation: The Roles of Stereotypes, Faces, and The Gaydar Myth. Cox WT, Devine PG, Bischmann AA, Hyde JS Journal of sex research 26219212 J Sex Res 2016 https://www.ncbi.nlm.nih.gov/pubmed/26219212
The motivation to express prejudice. Forscher PS, Cox WT, Graetz N, Devine PG Journal of personality and social psychology 26479365 J Pers Soc Psychol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26479365
Stereotypes possess heterogeneous directionality: a theoretical and empirical exploration of stereotype structure and content. Cox WT, Devine PG PloS one 25811181 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/25811181
A quantitative linguistic analysis of National Institutes of Health R01 application critiques from investigators at one institution. Kaatz A, Magua W, Zimmerman DR, Carnes M Academic medicine : journal of the Association of American Medical Colleges 25140529 Acad Med 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25140529
A Psychological Profile of the Alt-Right. Forscher PS, Kteily NS Perspectives on psychological science : a journal of the Association for Psychological Science 31747343 Perspect Psychol Sci 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31747343
Low agreement among reviewers evaluating the same NIH grant applications. Pier EL, Brauer M, Filut A, Kaatz A, Raclaw J, Nathan MJ, Ford CE, Carnes M Proceedings of the National Academy of Sciences of the United States of America 29507248 Proc Natl Acad Sci U S A 2018 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/29507248
Parents' Expectations for and Reactions to Children's Racial Biases. Scott KE, Shutts K, Devine PG Child development 30825398 Child Dev 2020 May https://www.ncbi.nlm.nih.gov/pubmed/30825398
Providing Epistemic Support For Assessments Through Mobile-Supported Sharing Activities. Raclaw J, Robles JS, DiDomenico SM Research on language and social interaction 28936031 Res Lang Soc Interact 2016 https://www.ncbi.nlm.nih.gov/pubmed/28936031
Are Female Applicants Disadvantaged in National Institutes of Health Peer Review? Combining Algorithmic Text Mining and Qualitative Methods to Detect Evaluative Differences in R01 Reviewers' Critiques. Magua W, Zhu X, Bhattacharya A, Filut A, Potvien A, Leatherberry R, Lee YG, Jens M, Malikireddy D, Carnes M, Kaatz A Journal of women's health (2002) 28281870 J Womens Health (Larchmt) 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28281870
A Gender Bias Habit-Breaking Intervention Led to Increased Hiring of Female Faculty in STEMM Departments. Devine PG, Forscher PS, Cox WTL, Kaatz A, Sheridan J, Carnes M Journal of experimental social psychology 29249837 J Exp Soc Psychol 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/29249837
Laughter and the Chair: Social Pressures Influencing Scoring During Grant Peer Review Meetings. Pier EL, Raclaw J, Carnes M, Ford CE, Kaatz A Journal of general internal medicine 30604119 J Gen Intern Med 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30604119
Breaking the prejudice habit: Mechanisms, timecourse, and longevity. Forscher PS, Mitamura C, Dix EL, Cox WTL, Devine PG Journal of experimental social psychology 29225371 J Exp Soc Psychol 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/29225371
Fair Play: A Study of Scientific Workforce Trainers' Experience Playing an Educational Video Game about Racial Bias. Kaatz A, Carnes M, Gutierrez B, Savoy J, Samuel C, Filut A, Pribbenow CM CBE life sciences education 28450447 CBE Life Sci Educ 2017 Summer https://www.ncbi.nlm.nih.gov/pubmed/28450447
Write More Articles, Get More Grants: The Impact of Department Climate on Faculty Research Productivity. Sheridan J, Savoy JN, Kaatz A, Lee YG, Filut A, Carnes M Journal of women's health (2002) 28375751 J Womens Health (Larchmt) 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28375751
'Your comments are meaner than your score': score calibration talk influences intra- and inter-panel variability during scientific grant peer review. Pier EL, Raclaw J, Kaatz A, Brauer M, Carnes M, Nathan MJ, Ford CE Research Evaluation 28458466 Res Eval 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/28458466
Analysis of National Institutes of Health R01 Application Critiques, Impact, and Criteria Scores: Does the Sex of the Principal Investigator Make a Difference? Kaatz A, Lee YG, Potvien A, Magua W, Filut A, Bhattacharya A, Leatherberry R, Zhu X, Carnes M Academic medicine : journal of the Association of American Medical Colleges 27276003 Acad Med 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27276003
Advancing Women's Health and Women's Leadership With Endowed Chairs in Women's Health. Carnes M, Johnson P, Klein W, Jenkins M, Bairey Merz CN Academic medicine : journal of the Association of American Medical Colleges 27759706 Acad Med 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27759706
Who Resembles a Scientific Leader-Jack or Jill? How Implicit Bias Could Influence Research Grant Funding. Kolehmainen C, Carnes M Circulation 29459461 Circulation 2018 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/29459461
Patterns of Feedback on the Bridge to Independence: A Qualitative Thematic Analysis of NIH Mentored Career Development Award Application Critiques. Kaatz A, Dattalo M, Regner C, Filut A, Carnes M Journal of women's health (2002) 26418619 J Womens Health (Larchmt) 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26418619
Stuck in the out-group: Jennifer can't grow up, Jane's invisible, and Janet's over the hill. Kaatz A, Carnes M Journal of women's health (2002) 24844292 J Womens Health (Larchmt) 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24844292
Threats to objectivity in peer review: the case of gender. Kaatz A, Gutierrez B, Carnes M Trends in pharmacological sciences 25086743 Trends Pharmacol Sci 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/25086743
Little race or gender bias in an experiment of initial review of NIH R01 grant proposals. Forscher PS, Cox WTL, Brauer M, Devine PG Nature human behaviour 30953009 Nat Hum Behav 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30953009
A meta-analysis of procedures to change implicit measures. Forscher PS, Lai CK, Axt JR, Ebersole CR, Herman M, Devine PG, Nosek BA Journal of personality and social psychology 31192631 J Pers Soc Psychol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31192631
Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. Farazi TA, Ten Hoeve JJ, Brown M, Mihailovic A, Horlings HM, van de Vijver MJ, Tuschl T, Wessels LF Genome biology 24398324 Genome Biol 2014 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/24398324
A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Tian Y, Simanshu DK, Ma JB, Park JE, Heo I, Kim VN, Patel DJ Molecular cell 24486018 Mol Cell 2014 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/24486018
Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch. Ren A, Wang XC, Kellenberger CA, Rajashankar KR, Jones RA, Hammond MC, Patel DJ Cell reports 25818298 Cell Rep 2015 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/25818298
omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data. Drewe-Boss P, Wessels HH, Ohler U Genome biology 30384847 Genome Biol 2018 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/30384847
Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Jia N, Mo CY, Wang C, Eng ET, Marraffini LA, Patel DJ Molecular cell 30503773 Mol Cell 2019 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/30503773
Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex. Guo TW, Bartesaghi A, Yang H, Falconieri V, Rao P, Merk A, Eng ET, Raczkowski AM, Fox T, Earl LA, Patel DJ, Subramaniam S Cell 28985564 Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28985564
The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N Nature communications 28685749 Nat Commun 2017 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/28685749
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction. Urdaneta EC, Vieira-Vieira CH, Hick T, Wessels HH, Figini D, Moschall R, Medenbach J, Ohler U, Granneman S, Selbach M, Beckmann BM Nature communications 30824702 Nat Commun 2019 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/30824702
Multicolor microRNA FISH effectively differentiates tumor types. Renwick N, Cekan P, Masry PA, McGeary SE, Miller JB, Hafner M, Li Z, Mihailovic A, Morozov P, Brown M, Gogakos T, Mobin MB, Snorrason EL, Feilotter HE, Zhang X, Perlis CS, Wu H, Suárez-Fariñas M, Feng H, Shuda M, Moore PS, Tron VA, Chang Y, Tuschl T The Journal of clinical investigation 23728175 J Clin Invest 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23728175
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M Nature communications 28963528 Nat Commun 2017 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/28963528
The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation. Meyer C, Garzia A, Morozov P, Molina H, Tuschl T Molecular cell 31981475 Mol Cell 2020 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/31981475
Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA. Liu Y, Esyunina D, Olovnikov I, Teplova M, Kulbachinskiy A, Aravin AA, Patel DJ Cell reports 29996105 Cell Rep 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29996105
Deciphering human ribonucleoprotein regulatory networks. Mukherjee N, Wessels HH, Lebedeva S, Sajek M, Ghanbari M, Garzia A, Munteanu A, Yusuf D, Farazi T, Hoell JI, Akat KM, Akalin A, Tuschl T, Ohler U Nucleic acids research 30517751 Nucleic Acids Res 2019 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/30517751
Global identification of functional microRNA-mRNA interactions in Drosophila. Wessels HH, Lebedeva S, Hirsekorn A, Wurmus R, Akalin A, Mukherjee N, Ohler U Nature communications 30967537 Nat Commun 2019 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/30967537
PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. Yang H, Gao P, Rajashankar KR, Patel DJ Cell 27984729 Cell 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27984729
Simultaneous detection of the subcellular localization of RNAs and proteins in cultured cells by combined multicolor RNA-FISH and IF. Meyer C, Garzia A, Tuschl T Methods (San Diego, Calif.) 27664292 Methods 2017 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/27664292
The mRNA-bound proteome of the early fly embryo. Wessels HH, Imami K, Baltz AG, Kolinski M, Beldovskaya A, Selbach M, Small S, Ohler U, Landthaler M Genome research 27197210 Genome Res 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27197210
Multi-disciplinary methods to define RNA-protein interactions and regulatory networks. Ascano M, Gerstberger S, Tuschl T Current opinion in genetics & development 23453689 Curr Opin Genet Dev 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23453689
Structure and function of the bacterial decapping enzyme NudC. Höfer K, Li S, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ, Jäschke A Nature chemical biology 27428510 Nat Chem Biol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27428510
Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. Teplova M, Farazi TA, Tuschl T, Patel DJ Quarterly reviews of biophysics 26347403 Q Rev Biophys 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26347403
Detecting actively translated open reading frames in ribosome profiling data. Calviello L, Mukherjee N, Wyler E, Zauber H, Hirsekorn A, Selbach M, Landthaler M, Obermayer B, Ohler U Nature methods 26657557 Nat Methods 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26657557
Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9. Yang H, Patel DJ Molecular cell 28602637 Mol Cell 2017 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/28602637
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T Molecular cell 29429924 Mol Cell 2018 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/29429924
SSMART: sequence-structure motif identification for RNA-binding proteins. Munteanu A, Mukherjee N, Ohler U Bioinformatics (Oxford, England) 29893814 Bioinformatics 2018 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/29893814
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ Proceedings of the National Academy of Sciences of the United States of America 31142647 Proc Natl Acad Sci U S A 2019 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/31142647
Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins. Garzia A, Meyer C, Morozov P, Sajek M, Tuschl T Methods (San Diego, Calif.) 27765618 Methods 2017 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/27765618
Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. Farazi TA, Leonhardt CS, Mukherjee N, Mihailovic A, Li S, Max KE, Meyer C, Yamaji M, Cekan P, Jacobs NC, Gerstberger S, Bognanni C, Larsson E, Ohler U, Tuschl T RNA (New York, N.Y.) 24860013 RNA 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24860013
DNA-guided DNA interference by a prokaryotic Argonaute. Swarts DC, Jore MM, Westra ER, Zhu Y, Janssen JH, Snijders AP, Wang Y, Patel DJ, Berenguer J, Brouns SJJ, van der Oost J Nature 24531762 Nature 2014 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/24531762
Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel DJ Genes & development 23630077 Genes Dev 2013 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/23630077
FMRP targets distinct mRNA sequence elements to regulate protein expression. Ascano M Jr, Mukherjee N, Bandaru P, Miller JB, Nusbaum JD, Corcoran DL, Langlois C, Munschauer M, Dewell S, Hafner M, Williams Z, Ohler U, Tuschl T Nature 23235829 Nature 2012 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/23235829
Integrative classification of human coding and noncoding genes through RNA metabolism profiles. Mukherjee N, Calviello L, Hirsekorn A, de Pretis S, Pelizzola M, Ohler U Nature structural & molecular biology 27870833 Nat Struct Mol Biol 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27870833
The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation. Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschl T, Stoffel M Nature communications 27665711 Nat Commun 2016 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/27665711
Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP. Vasilyev N, Polonskaia A, Darnell JC, Darnell RB, Patel DJ, Serganov A Proceedings of the National Academy of Sciences of the United States of America 26374839 Proc Natl Acad Sci U S A 2015 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/26374839
Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Murn J, Teplova M, Zarnack K, Shi Y, Patel DJ Nature structural & molecular biology 26641712 Nat Struct Mol Biol 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26641712
Global target mRNA specification and regulation by the RNA-binding protein ZFP36. Mukherjee N, Jacobs NC, Hafner M, Kennington EA, Nusbaum JD, Tuschl T, Blackshear PJ, Ohler U Genome biology 24401661 Genome Biol 2014 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/24401661
MicroRNA target site identification by integrating sequence and binding information. Majoros WH, Lekprasert P, Mukherjee N, Skalsky RL, Corcoran DL, Cullen BR, Ohler U Nature methods 23708386 Nat Methods 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23708386
The evolutionary journey of Argonaute proteins. Swarts DC, Makarova K, Wang Y, Nakanishi K, Ketting RF, Koonin EV, Patel DJ, van der Oost J Nature structural & molecular biology 25192263 Nat Struct Mol Biol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25192263
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T Nature 28297718 Nature 2017 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/28297718
A Three-Enzyme Pathway with an Optimised Geometric Arrangement to Facilitate Substrate Transfer. Liu M, Fu J, Qi X, Wootten S, Woodbury NW, Liu Y, Yan H Chembiochem : a European journal of chemical biology 26995014 Chembiochem 2016 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/26995014
Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion. Zhao Z, Fu J, Dhakal S, Johnson-Buck A, Liu M, Zhang T, Woodbury NW, Liu Y, Walter NG, Yan H Nature communications 26861509 Nat Commun 2016 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/26861509
Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing. Nakatsuka N, Yang KA, Abendroth JM, Cheung KM, Xu X, Yang H, Zhao C, Zhu B, Rim YS, Yang Y, Weiss PS, Stojanović MN, Andrews AM Science (New York, N.Y.) 30190311 Science 2018 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/30190311
DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury. Jiang D, Ge Z, Im HJ, England CG, Ni D, Hou J, Zhang L, Kutyreff CJ, Yan Y, Liu Y, Cho SY, Engle JW, Shi J, Huang P, Fan C, Yan H, Cai W Nature biomedical engineering 30505626 Nat Biomed Eng 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30505626
INTEGRATED MICROFLUIDIC SELEX USING FREE SOLUTION ELECTROKINETICS. Olsen TR, Tapia-Alveal C, Yang KA, Zhang X, Pereira LJ, Farmakidis N, Pei R, Stojanovic MN, Lin Q Journal of the Electrochemical Society 29170564 J Electrochem Soc 2017 https://www.ncbi.nlm.nih.gov/pubmed/29170564
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Li S, Jiang Q, Liu S, Zhang Y, Tian Y, Song C, Wang J, Zou Y, Anderson GJ, Han JY, Chang Y, Liu Y, Zhang C, Chen L, Zhou G, Nie G, Yan H, Ding B, Zhao Y Nature biotechnology 29431737 Nat Biotechnol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29431737
Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals. Simmons CR, Zhang F, MacCulloch T, Fahmi N, Stephanopoulos N, Liu Y, Seeman NC, Yan H Journal of the American Chemical Society 28731332 J Am Chem Soc 2017 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/28731332
Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Yang KA, Barbu M, Halim M, Pallavi P, Kim B, Kolpashchikov DM, Pecic S, Taylor S, Worgall TS, Stojanovic MN Nature chemistry 25343606 Nat Chem 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25343606
High-Affinity Nucleic-Acid-Based Receptors for Steroids. Yang KA, Chun H, Zhang Y, Pecic S, Nakatsuka N, Andrews AM, Worgall TS, Stojanovic MN ACS chemical biology 29083858 ACS Chem Biol 2017 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/29083858
Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation. Li J, Green AA, Yan H, Fan C Nature chemistry 29064489 Nat Chem 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/29064489
Autonomous molecular cascades for evaluation of cell surfaces. Rudchenko M, Taylor S, Pallavi P, Dechkovskaia A, Khan S, Butler VP Jr, Rudchenko S, Stojanovic MN Nature nanotechnology 23892986 Nat Nanotechnol 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23892986
Self-Assembly of Complex DNA Tessellations by Using Low-Symmetry Multi-arm DNA Tiles. Zhang F, Jiang S, Li W, Hunt A, Liu Y, Yan H Angewandte Chemie (International ed. in English) 27276237 Angew Chem Int Ed Engl 2016 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/27276237
In vitro selection and amplification protocols for isolation of aptameric sensors for small molecules. Yang KA, Pei R, Stojanovic MN Methods (San Diego, Calif.) 27155227 Methods 2016 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/27155227
Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore. Taylor SK, Tran TH, Liu MZ, Harris PE, Sun Y, Jambawalikar SR, Tong L, Stojanovic MN Chemistry (Weinheim an der Bergstrasse, Germany) 29873848 Chemistry 2018 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/29873848
Integrated Microfluidic Aptasensor for Mass Spectrometric Detection of Vasopressin in Human Plasma Ultrafiltrate. Yang J, Zhu J, Pei R, Oliver JA, Landry DW, Stojanovic MN, Lin Q Analytical methods : advancing methods and applications 28090219 Anal Methods 2016 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/28090219
Monovalent streptavidin that senses oligonucleotides. Taylor SK, Wang J, Kostic N, Stojanovic MN Angewandte Chemie (International ed. in English) 23606329 Angew Chem Int Ed Engl 2013 May 17 https://www.ncbi.nlm.nih.gov/pubmed/23606329
Amplification of Signal on Cell Surfaces in Molecular Cascades. Rudchenko S, Taylor S, Milosavic N, Rudchenko M, Wedderhoff Tissi B, Mapara MY, Stojanovic MN Cells 38132177 Cells 2023 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/38132177
An Integrated Microfluidic SELEX Approach Using Combined Electrokinetic and Hydrodynamic Manipulation. Olsen T, Zhu J, Kim J, Pei R, Stojanovic MN, Lin Q SLAS technology 27418370 SLAS Technol 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27418370
Self-Assembly of a 3D DNA Crystal Structure with Rationally Designed Six-Fold Symmetry. Zhang F, Simmons CR, Gates J, Liu Y, Yan H Angewandte Chemie (International ed. in English) 30066355 Angew Chem Int Ed Engl 2018 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/30066355
Integrated Microfluidic Isolation of Aptamers Using Electrophoretic Oligonucleotide Manipulation. Kim J, Olsen TR, Zhu J, Hilton JP, Yang KA, Pei R, Stojanovic MN, Lin Q Scientific reports 27217242 Sci Rep 2016 May 24 https://www.ncbi.nlm.nih.gov/pubmed/27217242
Robust spectrotemporal decomposition by iteratively reweighted least squares. Ba D, Babadi B, Purdon PL, Brown EN Proceedings of the National Academy of Sciences of the United States of America 25468968 Proc Natl Acad Sci U S A 2014 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/25468968
Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering 25284633 Int IEEE EMBS Conf Neural Eng 2013 https://www.ncbi.nlm.nih.gov/pubmed/25284633
The aging brain and anesthesia. Brown EN, Purdon PL Current opinion in anaesthesiology 23820102 Curr Opin Anaesthesiol 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23820102
Differential requirement for NMDAR activity in SAP97β-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses. Liu M, Lewis LD, Shi R, Brown EN, Xu W Journal of neurophysiology 24225540 J Neurophysiol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24225540
Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens. Varela C, Kumar S, Yang JY, Wilson MA Brain structure & function 23571778 Brain Struct Funct 2014 May https://www.ncbi.nlm.nih.gov/pubmed/23571778
Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies. Torres Cabán CC, Yang M, Lai C, Yang L, Subach FV, Smith BO, Piatkevich KD, Boyden ES ACS sensors 35427452 ACS Sens 2022 May 27 https://www.ncbi.nlm.nih.gov/pubmed/35427452
Acceptability and Feasibility of eSCCIP: Results From a Pilot Study of the Electronic Surviving Cancer Competently Intervention Program. Canter KS, Vega G, Perez Ramirez A, Munoz Osorio A, Thomas C, Lewis AM, Arasteh K, Kazak A Journal of pediatric psychology 36303445 J Pediatr Psychol 2023 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/36303445
Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 27178861 Clin Neurophysiol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27178861
State-space multitaper time-frequency analysis. Kim SE, Behr MK, Ba D, Brown EN Proceedings of the National Academy of Sciences of the United States of America 29255032 Proc Natl Acad Sci U S A 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29255032
Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging. Piatkevich KD, Suk HJ, Kodandaramaiah SB, Yoshida F, DeGennaro EM, Drobizhev M, Hughes TE, Desimone R, Boyden ES, Verkhusha VV Biophysical journal 29017728 Biophys J 2017 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/29017728
Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics. Linghu C, Johnson SL, Valdes PA, Shemesh OA, Park WM, Park D, Piatkevich KD, Wassie AT, Liu Y, An B, Barnes SA, Celiker OT, Yao CC, Yu CJ, Wang R, Adamala KP, Bear MF, Keating AE, Boyden ES Cell 33232692 Cell 2020 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/33232692
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies. Tillberg PW, Chen F, Piatkevich KD, Zhao Y, Yu CC, English BP, Gao L, Martorell A, Suk HJ, Yoshida F, DeGennaro EM, Roossien DH, Gong G, Seneviratne U, Tannenbaum SR, Desimone R, Cai D, Boyden ES Nature biotechnology 27376584 Nat Biotechnol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27376584
Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K Proceedings of the National Academy of Sciences of the United States of America 27791160 Proc Natl Acad Sci U S A 2016 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/27791160
Gamma frequency entrainment attenuates amyloid load and modifies microglia. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH Nature 27929004 Nature 2016 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/27929004
Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats. Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K Frontiers in neural circuits 28725184 Front Neural Circuits 2017 https://www.ncbi.nlm.nih.gov/pubmed/28725184
Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi. Barykina NV, Subach OM, Piatkevich KD, Jung EE, Malyshev AY, Smirnov IV, Bogorodskiy AO, Borshchevskiy VI, Varizhuk AM, Pozmogova GE, Boyden ES, Anokhin KV, Enikolopov GN, Subach FV PloS one 28837632 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/28837632
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH Cell 30879788 Cell 2019 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/30879788
Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia. Kelz MB, García PS, Mashour GA, Solt K Anesthesia and analgesia 30883418 Anesth Analg 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30883418
A Neurologic Examination for Anesthesiologists: Assessing Arousal Level during Induction, Maintenance, and Emergence. Reshef ER, Schiff ND, Brown EN Anesthesiology 30664547 Anesthesiology 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30664547
Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study. Koch S, Feinkohl I, Chakravarty S, Windmann V, Lichtner G, Pischon T, Brown EN, Spies C, BioCog Study Group Dementia and geriatric cognitive disorders 31578031 Dement Geriatr Cogn Disord 2019 https://www.ncbi.nlm.nih.gov/pubmed/31578031
Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia. Taylor NE, Chemali JJ, Brown EN, Solt K Anesthesiology 23221866 Anesthesiology 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23221866
Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN Anesthesiology 24398816 Anesthesiology 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24398816
Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 24110963 Annu Int Conf IEEE Eng Med Biol Soc 2013 https://www.ncbi.nlm.nih.gov/pubmed/24110963
A review of multitaper spectral analysis. Babadi B, Brown EN IEEE transactions on bio-medical engineering 24759284 IEEE Trans Biomed Eng 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24759284
Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems. Bianciardi M, Toschi N, Edlow BL, Eichner C, Setsompop K, Polimeni JR, Brown EN, Kinney HC, Rosen BR, Wald LL Brain connectivity 26066023 Brain Connect 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26066023
Nitrous oxide-induced slow and delta oscillations. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 26118489 Clin Neurophysiol 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26118489
Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN NeuroImage 26151100 Neuroimage 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26151100
Age-dependency of sevoflurane-induced electroencephalogram dynamics in children. Akeju O, Pavone KJ, Thum JA, Firth PG, Westover MB, Puglia M, Shank ES, Brown EN, Purdon PL British journal of anaesthesia 26174303 Br J Anaesth 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26174303
Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN IEEE transactions on bio-medical engineering 25935025 IEEE Trans Biomed Eng 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25935025
Delta frequency optogenetic stimulation of the thalamic nucleus reuniens is sufficient to produce working memory deficits: relevance to schizophrenia. Duan AR, Varela C, Zhang Y, Shen Y, Xiong L, Wilson MA, Lisman J Biological psychiatry 25891221 Biol Psychiatry 2015 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/25891221
An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals. Voigts J, Newman JP, Wilson MA, Harnett MT Journal of neural engineering 32074511 J Neural Eng 2020 May 19 https://www.ncbi.nlm.nih.gov/pubmed/32074511
Pharmacodynamic modeling of propofol-induced general anesthesia in young adults. Chakravarty S, Nikolaeva K, Kishnan D, Flores FJ, Purdon PL, Brown EN ... Health innovations and point-of-care technologies conference. Health innovations and point-of-care technologies conference 32803192 Health Innov Point Care Conf 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/32803192
An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 26736317 Annu Int Conf IEEE Eng Med Biol Soc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26736317
Spatial variation in automated burst suppression detection in pharmacologically induced coma. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 26738009 Annu Int Conf IEEE Eng Med Biol Soc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26738009
Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM Cell 29731170 Cell 2018 May 31 https://www.ncbi.nlm.nih.gov/pubmed/29731170
Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy. Zhao Y, Bucur O, Irshad H, Chen F, Weins A, Stancu AL, Oh EY, DiStasio M, Torous V, Glass B, Stillman IE, Schnitt SJ, Beck AH, Boyden ES Nature biotechnology 28714966 Nat Biotechnol 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28714966
Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Jingzhi An, Purdon PL, Solt K, Sims NM, Brown EN, Westover MB Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 29060851 Annu Int Conf IEEE Eng Med Biol Soc 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/29060851
Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O Anesthesiology 28092321 Anesthesiology 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28092321
Assessing neuronal interactions of cell assemblies during general anesthesia. Chen Z, Vijayan S, Ching S, Hale G, Flores FJ, Wilson MA, Brown EN Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22255259 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22255259
A brain-machine interface for control of medically-induced coma. Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN PLoS computational biology 24204231 PLoS Comput Biol 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/24204231
Statistical analysis of molecular signal recording. Glaser JI, Zamft BM, Marblestone AH, Moffitt JR, Tyo K, Boyden ES, Church G, Kording KP PLoS computational biology 23874187 PLoS Comput Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23874187
Local cortical dynamics of burst suppression in the anaesthetized brain. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL Brain : a journal of neurology 23887187 Brain 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23887187
Real-Time Readout of Large-Scale Unsorted Neural Ensemble Place Codes. Hu S, Ciliberti D, Grosmark AD, Michon F, Ji D, Penagos H, Buzsáki G, Wilson MA, Kloosterman F, Chen Z Cell reports 30517852 Cell Rep 2018 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/30517852
Variability in pharmacologically-induced coma for treatment of refractory status epilepticus. An J, Jonnalagadda D, Moura V Junior, Purdon PL, Brown EN, Westover MB PloS one 30379935 PLoS One 2018 https://www.ncbi.nlm.nih.gov/pubmed/30379935
Robust control of burst suppression for medical coma. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN Journal of neural engineering 26020243 J Neural Eng 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26020243
Functional and topological diversity of LOV domain photoreceptors. Glantz ST, Carpenter EJ, Melkonian M, Gardner KH, Boyden ES, Wong GK, Chow BY Proceedings of the National Academy of Sciences of the United States of America 26929367 Proc Natl Acad Sci U S A 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26929367
Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 29154132 Clin Neurophysiol 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29154132
Thalamocortical control of propofol phase-amplitude coupling. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N PLoS computational biology 29227992 PLoS Comput Biol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29227992
SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. Liu M, Shi R, Hwang H, Han KS, Wong MH, Ren X, Lewis LD, Brown EN, Xu W Journal of neurophysiology 30067114 J Neurophysiol 2018 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/30067114
Disruption of the ascending arousal network in acute traumatic disorders of consciousness. Snider SB, Bodien YG, Bianciardi M, Brown EN, Wu O, Edlow BL Neurology 31484715 Neurology 2019 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/31484715
The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray/Dorsal Raphe: Separating Analgesia and Anxiety. Taylor NE, Pei J, Zhang J, Vlasov KY, Davis T, Taylor E, Weng FJ, Van Dort CJ, Solt K, Brown EN eNeuro 31058210 eNeuro 2019 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/31058210
Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha. Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM BMC anesthesiology 28615047 BMC Anesthesiol 2017 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/28615047
Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O The Journal of neuroscience : the official journal of the Society for Neuroscience 28626012 J Neurosci 2017 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/28626012
Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O Frontiers in systems neuroscience 28611601 Front Syst Neurosci 2017 https://www.ncbi.nlm.nih.gov/pubmed/28611601
Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Van Dort CJ, Zachs DP, Kenny JD, Zheng S, Goldblum RR, Gelwan NA, Ramos DM, Nolan MA, Wang K, Weng FJ, Lin Y, Wilson MA, Brown EN Proceedings of the National Academy of Sciences of the United States of America 25548191 Proc Natl Acad Sci U S A 2015 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/25548191
A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Pierce ET, Walsh JL, Brown EN, Purdon PL Anesthesiology 25187999 Anesthesiology 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25187999
State-dependent architecture of thalamic reticular subnetworks. Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA Cell 25126786 Cell 2014 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/25126786
Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ Epilepsy & behavior : E&B 25771493 Epilepsy Behav 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25771493
Measuring the signal-to-noise ratio of a neuron. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temereanca S, Suzuki WA, Brown EN Proceedings of the National Academy of Sciences of the United States of America 25995363 Proc Natl Acad Sci U S A 2015 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/25995363
Thalamic reticular nucleus induces fast and local modulation of arousal state. Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN eLife 26460547 Elife 2015 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/26460547
Modeling the dynamical effects of anesthesia on brain circuits. Ching S, Brown EN Current opinion in neurobiology 24457211 Curr Opin Neurobiol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24457211
Thalamocortical mechanisms for the anteriorization of α rhythms during propofol-induced unconsciousness. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ The Journal of neuroscience : the official journal of the Society for Neuroscience 23825412 J Neurosci 2013 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/23825412
Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus. Siegle JH, Wilson MA eLife 25073927 Elife 2014 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/25073927
Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein. Subach OM, Sotskov VP, Plusnin VV, Gruzdeva AM, Barykina NV, Ivashkina OI, Anokhin KV, Nikolaeva AY, Korzhenevskiy DA, Vlaskina AV, Lazarenko VA, Boyko KM, Rakitina TV, Varizhuk AM, Pozmogova GE, Podgorny OV, Piatkevich KD, Boyden ES, Subach FV International journal of molecular sciences 32121243 Int J Mol Sci 2020 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/32121243
Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL eLife 25432022 Elife 2014 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/25432022
The human burst suppression electroencephalogram of deep hypothermia. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 25649968 Clin Neurophysiol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25649968
Phase organization of network computations. Wilson MA, Varela C, Remondes M Current opinion in neurobiology 25679370 Curr Opin Neurobiol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25679370
A high-density 3D localization algorithm for stochastic optical reconstruction microscopy. Babcock H, Sigal YM, Zhuang X Optical nanoscopy 25431749 Opt Nanoscopy 2012 https://www.ncbi.nlm.nih.gov/pubmed/25431749
Genome-wide study of mRNA degradation and transcript elongation in Escherichia coli. Chen H, Shiroguchi K, Ge H, Xie XS Molecular systems biology 25583150 Mol Syst Biol 2015 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/25583150
Isotropic 3D Super-resolution Imaging with a Self-bending Point Spread Function. Jia S, Vaughan JC, Zhuang X Nature photonics 25383090 Nat Photonics 2014 https://www.ncbi.nlm.nih.gov/pubmed/25383090
RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells. Chen KH, Boettiger AN, Moffitt JR, Wang S, Zhuang X Science (New York, N.Y.) 25858977 Science 2015 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/25858977
ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps. Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X Cell 23374341 Cell 2013 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/23374341
Chromosome organization by a nucleoid-associated protein in live bacteria. Wang W, Li GW, Chen C, Xie XS, Zhuang X Science (New York, N.Y.) 21903814 Science 2011 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/21903814
Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy. Zhao ZW, Roy R, Gebhardt JC, Suter DM, Chapman AR, Xie XS Proceedings of the National Academy of Sciences of the United States of America 24379392 Proc Natl Acad Sci U S A 2014 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/24379392
Fast compressed sensing analysis for super-resolution imaging using L1-homotopy. Babcock HP, Moffitt JR, Cao Y, Zhuang X Optics express 24514370 Opt Express 2013 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/24514370
Mapping Synaptic Input Fields of Neurons with Super-Resolution Imaging. Sigal YM, Speer CM, Babcock HP, Zhuang X Cell 26435106 Cell 2015 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/26435106
Mechanism of transcriptional bursting in bacteria. Chong S, Chen C, Ge H, Xie XS Cell 25036631 Cell 2014 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/25036631
Long-range attraction in aqueous colloidal suspensions. Zhao Q, Coult J, Pollack GH Proceedings of SPIE--the International Society for Optical Engineering 22065648 Proc SPIE Int Soc Opt Eng 2010 https://www.ncbi.nlm.nih.gov/pubmed/22065648
Contraction-Induced Changes in Hydrogen Bonding of Muscle Hydration Water. Yoo H, Nagornyak E, Das R, Wexler AD, Pollack GH The journal of physical chemistry letters 24803993 J Phys Chem Lett 2014 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/24803993
Exclusion-Zone Formation From Discontinuous Nafion Surfaces. Figueroa XA, Pollack GH International journal of design & nature and ecodynamics : a transdisciplinary journal relating to nature, science and the humanities 24826197 Int J Des Nat Ecodyn 2011 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/24826197
High electrical permittivity of ultrapure water at the water-platinum interface. Musumeci F, Pollack GH Chemical physics letters 25258452 Chem Phys Lett 2014 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/25258452
UNEXPECTED PRESENCE OF SOLUTE-FREE ZONES AT METAL-WATER INTERFACES. Chai B, Mahtani AG, Pollack GH Contemporary materials 23807904 Contemp Mater 2012 https://www.ncbi.nlm.nih.gov/pubmed/23807904
WATER, ENERGY AND LIFE: FRESH VIEWS FROM THE WATER'S EDGE. Pollack GH International journal of design & nature and ecodynamics : a transdisciplinary journal relating to nature, science and the humanities 22977460 Int J Des Nat Ecodyn 2010 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/22977460
Effect of hyperbaric oxygen conditions on the ordering of interfacial water. Ypma RE, Pollack GH Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 26152107 Undersea Hyperb Med 2015 May-Jun https://www.ncbi.nlm.nih.gov/pubmed/26152107
On the driver of blood circulation beyond the heart. Li Z, Pollack GH PloS one 37856567 PLoS One 2023 https://www.ncbi.nlm.nih.gov/pubmed/37856567
Charge-based forces at the Nafion-water interface. Das R, Pollack GH Langmuir : the ACS journal of surfaces and colloids 23311934 Langmuir 2013 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/23311934
Influence of water on the work function of certain metals. Musumeci F, Pollack GH Chemical physics letters 22639466 Chem Phys Lett 2012 May 21 https://www.ncbi.nlm.nih.gov/pubmed/22639466
Solute-free interfacial zones in polar liquids. Chai B, Pollack GH The journal of physical chemistry. B 20369860 J Phys Chem B 2010 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/20369860
Persisting water droplets on water surfaces. Klyuzhin IS, Ienna F, Roeder B, Wexler A, Pollack GH The journal of physical chemistry. B 20961076 J Phys Chem B 2010 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/20961076
Light-induced effects on Brownian displacements. Bhalerao AS, Pollack GH Journal of biophotonics 21287689 J Biophotonics 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21287689
Unexpected water flow through Nafion-tube punctures. O'Rourke C, Klyuzhin I, Park JS, Pollack GH Physical review. E, Statistical, nonlinear, and soft matter physics 21728645 Phys Rev E Stat Nonlin Soft Matter Phys 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21728645
EFFECT OF PARTICLE DIAMETER ON EXCLUSION-ZONE SIZE. Nhan DT, Pollack GH International journal of design & nature and ecodynamics : a transdisciplinary journal relating to nature, science and the humanities 22389653 Int J Des Nat Ecodyn 2011 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/22389653
Impact of Hydrophilic Surfaces on Interfacial Water Dynamics Probed with NMR Spectroscopy. Yoo H, Paranji R, Pollack GH The journal of physical chemistry letters 22003430 J Phys Chem Lett 2011 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/22003430
Effect of Local and General Anesthetics on Interfacial Water. Kundacina N, Shi M, Pollack GH PloS one 27054588 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27054588
Particle Displacement in Aqueous Suspension Arising from Incident Radiant Energy. Kimura KW, Pollack GH Langmuir : the ACS journal of surfaces and colloids 26335979 Langmuir 2015 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/26335979
A peptide tag system for facile purification and single-molecule immobilization. Huang J, Nagy SS, Koide A, Rock RS, Koide S Biochemistry 19928925 Biochemistry 2009 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/19928925
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design. Gilbreth RN, Truong K, Madu I, Koide A, Wojcik JB, Li NS, Piccirilli JA, Chen Y, Koide S Proceedings of the National Academy of Sciences of the United States of America 21518904 Proc Natl Acad Sci U S A 2011 May 10 https://www.ncbi.nlm.nih.gov/pubmed/21518904
Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution. Huang J, Makabe K, Biancalana M, Koide A, Koide S Journal of molecular biology 19646997 J Mol Biol 2009 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/19646997
Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Lu M, Symersky J, Radchenko M, Koide A, Guo Y, Nie R, Koide S Proceedings of the National Academy of Sciences of the United States of America 23341609 Proc Natl Acad Sci U S A 2013 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/23341609
Affinity maturation of single-domain antibodies by yeast surface display. Koide A, Koide S Methods in molecular biology (Clifton, N.J.) 22886267 Methods Mol Biol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22886267
Structural insights for engineering binding proteins based on non-antibody scaffolds. Gilbreth RN, Koide S Current opinion in structural biology 22749196 Curr Opin Struct Biol 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22749196
Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation. Yasui N, Findlay GM, Gish GD, Hsiung MS, Huang J, Tucholska M, Taylor L, Smith L, Boldridge WC, Koide A, Pawson T, Koide S Molecular cell 24910098 Mol Cell 2014 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/24910098
Architecture of the fungal nuclear pore inner ring complex. Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A Science (New York, N.Y.) 26316600 Science 2015 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/26316600
Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. Wojcik J, Lamontanara AJ, Grabe G, Koide A, Akin L, Gerig B, Hantschel O, Koide S The Journal of biological chemistry 26912659 J Biol Chem 2016 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/26912659
Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. Kükenshöner T, Schmit NE, Bouda E, Sha F, Pojer F, Koide A, Seeliger M, Koide S, Hantschel O Journal of molecular biology 28347651 J Mol Biol 2017 May 5 https://www.ncbi.nlm.nih.gov/pubmed/28347651
Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules. Koide S Current opinion in biotechnology 19700302 Curr Opin Biotechnol 2009 Aug https://www.ncbi.nlm.nih.gov/pubmed/19700302
Target-binding proteins based on the 10th human fibronectin type III domain (¹⁰Fn3). Koide S, Koide A, Lipovšek D Methods in enzymology 22230568 Methods Enzymol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22230568
Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. Koide A, Wojcik J, Gilbreth RN, Hoey RJ, Koide S Journal of molecular biology 22198408 J Mol Biol 2012 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/22198408
ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, Wysocka J eLife 26523391 Elife 2015 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/26523391
Inhibition of RAS function through targeting an allosteric regulatory site. Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP Nature chemical biology 27820802 Nat Chem Biol 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27820802
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O Nature communications 29235475 Nat Commun 2017 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/29235475
Targeting the α4-α5 interface of RAS results in multiple levels of inhibition. Spencer-Smith R, Li L, Prasad S, Koide A, Koide S, O'Bryan JP Small GTPases 28692342 Small GTPases 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/28692342
Rational conversion of affinity reagents into label-free sensors for Peptide motifs by designed allostery. Huang J, Koide S ACS chemical biology 20143785 ACS Chem Biol 2010 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/20143785
Generation of high-performance binding proteins for peptide motifs by affinity clamping. Koide S, Huang J Methods in enzymology 23422435 Methods Enzymol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23422435
Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Sha F, Gencer EB, Georgeon S, Koide A, Yasui N, Koide S, Hantschel O Proceedings of the National Academy of Sciences of the United States of America 23980151 Proc Natl Acad Sci U S A 2013 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/23980151
Allosteric modulation of a human protein kinase with monobodies. Zorba A, Nguyen V, Koide A, Hoemberger M, Zheng Y, Kutter S, Kim C, Koide S, Kern D Proceedings of the National Academy of Sciences of the United States of America 31239342 Proc Natl Acad Sci U S A 2019 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/31239342
Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin. Puttamadappa SS, Jagadish K, Shekhtman A, Camarero JA Angewandte Chemie (International ed. in English) 20715250 Angew Chem Int Ed Engl 2010 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/20715250
Photomodulation of protein trans-splicing through backbone photocaging of the DnaE split intein. Berrade L, Kwon Y, Camarero JA Chembiochem : a European journal of chemical biology 20512791 Chembiochem 2010 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/20512791
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery. Gould A, Ji Y, Aboye TL, Camarero JA Current pharmaceutical design 22204428 Curr Pharm Des 2011 Dec https://www.ncbi.nlm.nih.gov/pubmed/22204428
Recombinant production of rhesus θ-defensin-1 (RTD-1) using a bacterial expression system. Gould A, Li Y, Majumder S, Garcia AE, Carlsson P, Shekhtman A, Camarero JA Molecular bioSystems 22327102 Mol Biosyst 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22327102
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. Aboye TL, Ha H, Majumder S, Christ F, Debyser Z, Shekhtman A, Neamati N, Camarero JA Journal of medicinal chemistry 23151033 J Med Chem 2012 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/23151033
Rapid parallel synthesis of bioactive folded cyclotides by using a tea-bag approach. Aboye T, Kuang Y, Neamati N, Camarero JA Chembiochem : a European journal of chemical biology 25663016 Chembiochem 2015 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/25663016
Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions. Jagadish K, Borra R, Lacey V, Majumder S, Shekhtman A, Wang L, Camarero JA Angewandte Chemie (International ed. in English) 23322720 Angew Chem Int Ed Engl 2013 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/23322720
Chemical and biological production of cyclotides. Li Y, Bi T, Camarero JA Advances in botanical research 27064329 Adv Bot Res 2015 https://www.ncbi.nlm.nih.gov/pubmed/27064329
Cyclotides, a versatile ultrastable micro-protein scaffold for biotechnological applications. Camarero JA Bioorganic & medicinal chemistry letters 29110985 Bioorg Med Chem Lett 2017 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/29110985
In-cell production of a genetically-encoded library based on the θ-defensin RTD-1 using a bacterial expression system. Bi T, Li Y, Shekhtman A, Camarero JA Bioorganic & medicinal chemistry 28927803 Bioorg Med Chem 2018 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/28927803
In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. Ji Y, Majumder S, Millard M, Borra R, Bi T, Elnagar AY, Neamati N, Shekhtman A, Camarero JA Journal of the American Chemical Society 23848581 J Am Chem Soc 2013 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/23848581
In-cell fluorescence activation and labeling of proteins mediated by FRET-quenched split inteins. Borra R, Dong D, Elnagar AY, Woldemariam GA, Camarero JA Journal of the American Chemical Society 22404648 J Am Chem Soc 2012 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/22404648
Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1). Aboye TL, Li Y, Majumder S, Hao J, Shekhtman A, Camarero JA Bioorganic & medicinal chemistry letters 22425570 Bioorg Med Chem Lett 2012 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/22425570
Expressed protein ligation: a resourceful tool to study protein structure and function. Berrade L, Camarero JA Cellular and molecular life sciences : CMLS 19685006 Cell Mol Life Sci 2009 Dec https://www.ncbi.nlm.nih.gov/pubmed/19685006
Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics. Garcia AE, Camarero JA Current molecular pharmacology 20858197 Curr Mol Pharmacol 2010 Nov https://www.ncbi.nlm.nih.gov/pubmed/20858197
Legume cyclotides shed light on the genetic origin of knotted circular proteins. Camarero JA Proceedings of the National Academy of Sciences of the United States of America 21653883 Proc Natl Acad Sci U S A 2011 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/21653883
Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing. Li Y, Aboye T, Breindel L, Shekhtman A, Camarero JA Biopolymers 27178003 Biopolymers 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27178003
Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity. Aboye T, Meeks CJ, Majumder S, Shekhtman A, Rodgers K, Camarero JA Molecules (Basel, Switzerland) 26821010 Molecules 2016 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/26821010
Recombinant Expression of Cyclotides Using Split Inteins. Jagadish K, Camarero JA Methods in molecular biology (Clifton, N.J.) 27714609 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/27714609
Protein Chemical Modification Inside Living Cells Using Split Inteins. Borra R, Camarero JA Methods in molecular biology (Clifton, N.J.) 27714613 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/27714613
In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent. Lesniak WG, Aboye T, Chatterjee S, Camarero JA, Nimmagadda S Chemistry (Weinheim an der Bergstrasse, Germany) 28771849 Chemistry 2017 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/28771849
In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1. Austin J, Kimura RH, Woo YH, Camarero JA Amino acids 19685144 Amino Acids 2010 May https://www.ncbi.nlm.nih.gov/pubmed/19685144
Optimizing the future for biotechnology therapies, the key role of protein engineering. Camarero JA Advanced drug delivery reviews 19735684 Adv Drug Deliv Rev 2009 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/19735684
"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides. Sancheti H, Camarero JA Advanced drug delivery reviews 19628015 Adv Drug Deliv Rev 2009 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/19628015
Cyclotides, a promising molecular scaffold for peptide-based therapeutics. Jagadish K, Camarero JA Biopolymers 20564025 Biopolymers 2010 https://www.ncbi.nlm.nih.gov/pubmed/20564025
Recombinant expression of backbone-cyclized polypeptides. Borra R, Camarero JA Biopolymers 23893781 Biopolymers 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23893781
Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain. Schumann FH, Varadan R, Tayakuniyil PP, Grossman JH, Camarero JA, Fushman D Frontiers in chemistry 25905098 Front Chem 2015 https://www.ncbi.nlm.nih.gov/pubmed/25905098
Recombinant Expression and Phenotypic Screening of a Bioactive Cyclotide Against α-Synuclein-Induced Cytotoxicity in Baker's Yeast. Jagadish K, Gould A, Borra R, Majumder S, Mushtaq Z, Shekhtman A, Camarero JA Angewandte Chemie (International ed. in English) 26096948 Angew Chem Int Ed Engl 2015 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/26096948
Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I. Austin J, Wang W, Puttamadappa S, Shekhtman A, Camarero JA Chembiochem : a European journal of chemical biology 19780078 Chembiochem 2009 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/19780078
Protein microarrays: novel developments and applications. Berrade L, Garcia AE, Camarero JA Pharmaceutical research 21116694 Pharm Res 2011 Jul https://www.ncbi.nlm.nih.gov/pubmed/21116694
Biological synthesis of circular polypeptides. Aboye TL, Camarero JA The Journal of biological chemistry 22707722 J Biol Chem 2012 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/22707722
Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA Biochemistry 22040603 Biochemistry 2011 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/22040603
Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. Contreras J, Elnagar AY, Hamm-Alvarez SF, Camarero JA Journal of controlled release : official journal of the Controlled Release Society 21906641 J Control Release 2011 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/21906641
Cyclotides: Overview and Biotechnological Applications. Gould A, Camarero JA Chembiochem : a European journal of chemical biology 28544675 Chembiochem 2017 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/28544675
Full Sequence Amino Acid Scanning of θ-Defensin RTD-1 Yields a Potent Anthrax Lethal Factor Protease Inhibitor. Li Y, Gould A, Aboye T, Bi T, Breindel L, Shekhtman A, Camarero JA Journal of medicinal chemistry 28151653 J Med Chem 2017 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/28151653
Intein applications: from protein purification and labeling to metabolic control methods. Wood DW, Camarero JA The Journal of biological chemistry 24700459 J Biol Chem 2014 May 23 https://www.ncbi.nlm.nih.gov/pubmed/24700459
Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis. Conibear AC, Wang CK, Bi T, Rosengren KJ, Camarero JA, Craik DJ The journal of physical chemistry. B 25375365 J Phys Chem B 2014 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/25375365
Defining NELF-E RNA binding in HIV-1 and promoter-proximal pause regions. Pagano JM, Kwak H, Waters CT, Sprouse RO, White BS, Ozer A, Szeto K, Shalloway D, Craighead HG, Lis JT PLoS genetics 24453987 PLoS Genet 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24453987
High-throughput binding characterization of RNA aptamer selections using a microplate-based multiplex microcolumn device. Szeto K, Reinholt SJ, Duarte FM, Pagano JM, Ozer A, Yao L, Lis JT, Craighead HG Analytical and bioanalytical chemistry 24553662 Anal Bioanal Chem 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24553662
RAPID-SELEX for RNA aptamers. Szeto K, Latulippe DR, Ozer A, Pagano JM, White BS, Shalloway D, Lis JT, Craighead HG PloS one 24376564 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24376564
New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization. Ozer A, Pagano JM, Lis JT Molecular therapy. Nucleic acids 25093707 Mol Ther Nucleic Acids 2014 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/25093707
Novel strategy for selection of monoclonal antibodies against highly conserved antigens: phage library panning against ephrin-B2 displayed on yeast. Gu X, Vedvyas Y, Chen X, Kaushik T, Hwang CI, Hu X, Nikitin AY, Jin MM PloS one 22292016 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22292016
Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions. Park S, Kang S, Veach AJ, Vedvyas Y, Zarnegar R, Kim JY, Jin MM Biomaterials 20667589 Biomaterials 2010 Oct https://www.ncbi.nlm.nih.gov/pubmed/20667589
Cell surface assembly of HIV gp41 six-helix bundles for facile, quantitative measurements of hetero-oligomeric interactions. Hu X, Saha P, Chen X, Kim D, Devarasetty M, Varadarajan R, Jin MM Journal of the American Chemical Society 22888993 J Am Chem Soc 2012 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/22888993
Structural basis for conformational switching and GTP loading of the large G protein atlastin. Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H The EMBO journal 23334294 EMBO J 2013 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/23334294
Multiplexed microcolumn-based process for efficient selection of RNA aptamers. Latulippe DR, Szeto K, Ozer A, Duarte FM, Kelly CV, Pagano JM, White BS, Shalloway D, Lis JT, Craighead HG Analytical chemistry 23398198 Anal Chem 2013 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/23398198
Density-dependent cooperative non-specific binding in solid-phase SELEX affinity selection. Ozer A, White BS, Lis JT, Shalloway D Nucleic acids research 23737446 Nucleic Acids Res 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23737446
Discovering aptamers by cell-SELEX against human soluble growth factors ectopically expressed on yeast cell surface. Meng HW, Pagano JM, White BS, Toyoda Y, Min IM, Craighead HG, Shalloway D, Lis JT, Xiao K, Jin MM PloS one 24675636 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24675636
Quantitative assessment of RNA-protein interactions with high-throughput sequencing-RNA affinity profiling. Ozer A, Tome JM, Friedman RC, Gheba D, Schroth GP, Lis JT Nature protocols 26182240 Nat Protoc 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26182240
Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation. Chen X, Wong R, Khalidov I, Wang AY, Leelawattanachai J, Wang Y, Jin MM Biomaterials 21783245 Biomaterials 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21783245
Highly Multiplexed RNA Aptamer Selection using a Microplate-based Microcolumn Device. Reinholt SJ, Ozer A, Lis JT, Craighead HG Scientific reports 27432610 Sci Rep 2016 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/27432610
Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling. Tome JM, Ozer A, Pagano JM, Gheba D, Schroth GP, Lis JT Nature methods 24809628 Nat Methods 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24809628
What's wrong with correlative experiments? Vilela M, Danuser G Nature cell biology 21892139 Nat Cell Biol 2011 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/21892139
Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature. Elliott H, Fischer RS, Myers KA, Desai RA, Gao L, Chen CS, Adelstein RS, Waterman CM, Danuser G Nature cell biology 25621949 Nat Cell Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25621949
Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Hinde E, Digman MA, Hahn KM, Gratton E Proceedings of the National Academy of Sciences of the United States of America 23248275 Proc Natl Acad Sci U S A 2013 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/23248275
Imaging the coordination of multiple signalling activities in living cells. Welch CM, Elliott H, Danuser G, Hahn KM Nature reviews. Molecular cell biology 22016058 Nat Rev Mol Cell Biol 2011 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/22016058
Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. Kummer L, Hsu CW, Dagliyan O, MacNevin C, Kaufholz M, Zimmermann B, Dokholyan NV, Hahn KM, Plückthun A Chemistry & biology 23790495 Chem Biol 2013 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/23790495
A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells. Zawistowski JS, Sabouri-Ghomi M, Danuser G, Hahn KM, Hodgson L PloS one 24224016 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24224016
LOVTRAP: an optogenetic system for photoinduced protein dissociation. Wang H, Vilela M, Winkler A, Tarnawski M, Schlichting I, Yumerefendi H, Kuhlman B, Liu R, Danuser G, Hahn KM Nature methods 27427858 Nat Methods 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27427858
Delivery of membrane impermeable cargo into CHO cells by peptide nanoparticles targeted by a protein corona. Dittrich C, Burckhardt CJ, Danuser G Biomaterials 22226586 Biomaterials 2012 Mar https://www.ncbi.nlm.nih.gov/pubmed/22226586
Fluctuation analysis of activity biosensor images for the study of information flow in signaling pathways. Vilela M, Halidi N, Besson S, Elliott H, Hahn K, Tytell J, Danuser G Methods in enzymology 23280114 Methods Enzymol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23280114
FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, Hahn KM Nature chemical biology 27501396 Nat Chem Biol 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27501396
Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Hinde E, Yokomori K, Gaus K, Hahn KM, Gratton E Scientific reports 24573109 Sci Rep 2014 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/24573109
Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides. Yi JJ, Wang H, Vilela M, Danuser G, Hahn KM ACS synthetic biology 24905630 ACS Synth Biol 2014 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/24905630
Humanin: a harbinger of mitochondrial-derived peptides? Lee C, Yen K, Cohen P Trends in endocrinology and metabolism: TEM 23402768 Trends Endocrinol Metab 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23402768
IGF-I regulates the age-dependent signaling peptide humanin. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P Aging cell 25040290 Aging Cell 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25040290
The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Jia Y, Ohanyan A, Lue YH, Swerdloff RS, Liu PY, Cohen P, Wang C Apoptosis : an international journal on programmed cell death 25666707 Apoptosis 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25666707
Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. Paharkova V, Alvarez G, Nakamura H, Cohen P, Lee KW Molecular and cellular endocrinology 26116236 Mol Cell Endocrinol 2015 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/26116236
Humanin: Functional Interfaces with IGF-I. Xiao J, Kim SJ, Cohen P, Yen K Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 27082450 Growth Horm IGF Res 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27082450
Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Oh YK, Bachar AR, Zacharias DG, Kim SG, Wan J, Cobb LJ, Lerman LO, Cohen P, Lerman A Atherosclerosis 21763658 Atherosclerosis 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21763658
Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. Kim SJ, Xiao J, Cohen P, Yen K Journal of visualized experiments : JoVE 28994791 J Vis Exp 2017 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/28994791
The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K Oncotarget 27384491 Oncotarget 2016 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/27384491
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R Cell metabolism 27304509 Cell Metab 2016 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/27304509
The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C Endocrinology 26384090 Endocrinology 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26384090
Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Zhang X, Urbieta-Caceres VH, Eirin A, Bell CC, Crane JA, Tang H, Jordan KL, Oh YK, Zhu XY, Korsmo MJ, Bachar AR, Cohen P, Lerman A, Lerman LO Life sciences 22820173 Life Sci 2012 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/22820173
Circulating humanin levels are associated with preserved coronary endothelial function. Widmer RJ, Flammer AJ, Herrmann J, Rodriguez-Porcel M, Wan J, Cohen P, Lerman LO, Lerman A American journal of physiology. Heart and circulatory physiology 23220334 Am J Physiol Heart Circ Physiol 2013 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/23220334
New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. Cohen P Journal of the National Cancer Institute 24586106 J Natl Cancer Inst 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24586106
Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans. Zacharias DG, Kim SG, Massat AE, Bachar AR, Oh YK, Herrmann J, Rodriguez-Porcel M, Cohen P, Lerman LO, Lerman A PloS one 22328926 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22328926
The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis. Jia Y, Lue YH, Swerdloff R, Lee KW, Cobb LJ, Cohen P, Wang C Andrology 23686888 Andrology 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23686888
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P Cell metabolism 25738459 Cell Metab 2015 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/25738459
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Lee C, Kim KH, Cohen P Free radical biology & medicine 27216708 Free Radic Biol Med 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27216708
The association between circulating microRNA levels and coronary endothelial function. Widmer RJ, Chung WY, Herrmann J, Jordan KL, Lerman LO, Lerman A PloS one 25310838 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25310838
The emerging role of the mitochondrial-derived peptide humanin in stress resistance. Yen K, Lee C, Mehta H, Cohen P Journal of molecular endocrinology 23239898 J Mol Endocrinol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23239898
Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Huffman DM, Farias Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N Aging cell 26534869 Aging Cell 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26534869
International collaboration: promises and challenges. Widmer RJ, Widmer JM, Lerman A Rambam Maimonides medical journal 25973264 Rambam Maimonides Med J 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25973264
Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P Aging 27070352 Aging (Albany NY) 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/27070352
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR Investigative ophthalmology & visual science 26990160 Invest Ophthalmol Vis Sci 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26990160
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM Nature communications 29921922 Nat Commun 2018 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/29921922
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis. Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson B, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B American journal of physiology. Gastrointestinal and liver physiology 24904080 Am J Physiol Gastrointest Liver Physiol 2014 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/24904080
A randomized controlled trial to evaluate the effects of high-dose versus low-dose of arginine therapy on hepatic function tests in argininosuccinic aciduria. Nagamani SC, Shchelochkov OA, Mullins MA, Carter S, Lanpher BC, Sun Q, Kleppe S, Erez A, O'Brian Smith E, Marini JC, Members of the Urea Cycle Disorders Consortium, Lee B Molecular genetics and metabolism 23040521 Mol Genet Metab 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/23040521
Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Erez A, Nagamani SC, Lee B American journal of medical genetics. Part C, Seminars in medical genetics 21312326 Am J Med Genet C Semin Med Genet 2011 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/21312326
Systemic hypertension in two patients with ASL deficiency: a result of nitric oxide deficiency? Brunetti-Pierri N, Erez A, Shchelochkov O, Craigen W, Lee B Molecular genetics and metabolism 19592285 Mol Genet Metab 2009 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/19592285
Requirement of argininosuccinate lyase for systemic nitric oxide production. Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B Nature medicine 22081021 Nat Med 2011 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/22081021
Argininosuccinate lyase deficiency. Nagamani SC, Erez A, Lee B Genetics in medicine : official journal of the American College of Medical Genetics 22241104 Genet Med 2012 May https://www.ncbi.nlm.nih.gov/pubmed/22241104
Concentration- and stage-specific effects of nitrite on colon cancer cell lines. Jiang H, Tang Y, Garg HK, Parthasarathy DK, Torregrossa AC, Hord NG, Bryan NS Nitric oxide : biology and chemistry 22504070 Nitric Oxide 2012 May 15 https://www.ncbi.nlm.nih.gov/pubmed/22504070
Optimizing therapy for argininosuccinic aciduria. Nagamani SC, Lee B, Erez A Molecular genetics and metabolism 22841516 Mol Genet Metab 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22841516
Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Nagamani SC, Campeau PM, Shchelochkov OA, Premkumar MH, Guse K, Brunetti-Pierri N, Chen Y, Sun Q, Tang Y, Palmer D, Reddy AK, Li L, Slesnick TC, Feig DI, Caudle S, Harrison D, Salviati L, Marini JC, Bryan NS, Erez A, Lee B American journal of human genetics 22541557 Am J Hum Genet 2012 May 4 https://www.ncbi.nlm.nih.gov/pubmed/22541557
Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism. Erez A, Shchelochkov OA, Plon SE, Scaglia F, Lee B American journal of human genetics 21473982 Am J Hum Genet 2011 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/21473982
Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling. Clay HB, Parl AK, Mitchell SL, Singh L, Bell LN, Murdock DG PloS one 26963735 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/26963735
The mitochondrial fatty acid synthesis (mtFASII) pathway is capable of mediating nuclear-mitochondrial cross talk through the PPAR system of transcriptional activation. Parl A, Mitchell SL, Clay HB, Reiss S, Li Z, Murdock DG Biochemical and biophysical research communications 24161390 Biochem Biophys Res Commun 2013 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/24161390
Origins of cellular geometry. Marshall WF BMC biology 21880160 BMC Biol 2011 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/21880160
The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell. Slabodnick MM, Ruby JG, Reiff SB, Swart EC, Gosai S, Prabakaran S, Witkowska E, Larue GE, Fisher S, Freeman RM Jr, Gunawardena J, Chu W, Stover NA, Gregory BD, Nowacki M, Derisi J, Roy SW, Marshall WF, Sood P Current biology : CB 28190732 Curr Biol 2017 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/28190732
The kinase regulator mob1 acts as a patterning protein for stentor morphogenesis. Slabodnick MM, Ruby JG, Dunn JG, Feldman JL, DeRisi JL, Marshall WF PLoS biology 24823688 PLoS Biol 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24823688
Visualizing cytoplasmic flow during single-cell wound healing in Stentor coeruleus. Slabodnick M, Prevo B, Gross P, Sheung J, Marshall W Journal of visualized experiments : JoVE 24378633 J Vis Exp 2013 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/24378633
Introduction of mismatches in a random shRNA-encoding library improves potency for phenotypic selection. Wang Y, Speier JS, Engram-Pearl J, Wilson RB PloS one 24498319 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24498319
Phenotypic Screening for Friedreich Ataxia Using Random shRNA Selection. Cotticelli MG, Acquaviva F, Xia S, Kaur A, Wang Y, Wilson RB Journal of biomolecular screening 26286937 J Biomol Screen 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26286937
Human high-altitude adaptation: forward genetics meets the HIF pathway. Bigham AW, Lee FS Genes & development 25319824 Genes Dev 2014 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/25319824
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway. Song D, Li LS, Heaton-Johnson KJ, Arsenault PR, Master SR, Lee FS The Journal of biological chemistry 23413029 J Biol Chem 2013 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/23413029
Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing. Song D, Li LS, Arsenault PR, Tan Q, Bigham AW, Heaton-Johnson KJ, Master SR, Lee FS The Journal of biological chemistry 24711448 J Biol Chem 2014 May 23 https://www.ncbi.nlm.nih.gov/pubmed/24711448
Identification of prolyl hydroxylation modifications in mammalian cell proteins. Arsenault PR, Heaton-Johnson KJ, Li LS, Song D, Ferreira VS, Patel N, Master SR, Lee FS Proteomics 25421965 Proteomics 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25421965
Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting. Bird GH, Crannell WC, Walensky LD Current protocols in chemical biology 23801563 Curr Protoc Chem Biol 2011 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/23801563
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH Nature chemical biology 23974116 Nat Chem Biol 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23974116
Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Lee S, Braun CR, Bird GH, Walensky LD Methods in enzymology 24974285 Methods Enzymol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24974285
Direct activation of full-length proapoptotic BAK. Leshchiner ES, Braun CR, Bird GH, Walensky LD Proceedings of the National Academy of Sciences of the United States of America 23404709 Proc Natl Acad Sci U S A 2013 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/23404709
Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD Chemistry & biology 21168768 Chem Biol 2010 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/21168768
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD Proceedings of the National Academy of Sciences of the United States of America 25624485 Proc Natl Acad Sci U S A 2015 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/25624485
Protein-protein interactions: A PUMA mechanism unfolds. Walensky LD Nature chemical biology 23416398 Nat Chem Biol 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23416398
Direct BAKtivation. Walensky LD Nature structural & molecular biology 23649360 Nat Struct Mol Biol 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23649360
Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD ACS chemical biology 24358963 ACS Chem Biol 2014 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/24358963
Playing fullBAK. Walensky LD Cell cycle (Georgetown, Tex.) 23588072 Cell Cycle 2013 May 1 https://www.ncbi.nlm.nih.gov/pubmed/23588072
Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Edwards AL, Gavathiotis E, LaBelle JL, Braun CR, Opoku-Nsiah KA, Bird GH, Walensky LD Chemistry & biology 23890007 Chem Biol 2013 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/23890007
A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators. Szlyk B, Braun CR, Ljubicic S, Patton E, Bird GH, Osundiji MA, Matschinsky FM, Walensky LD, Danial NN Nature structural & molecular biology 24317490 Nat Struct Mol Biol 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24317490
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD Molecular cell 25684204 Mol Cell 2015 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/25684204
Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes. Ljubicic S, Polak K, Fu A, Wiwczar J, Szlyk B, Chang Y, Alvarez-Perez JC, Bird GH, Walensky LD, Garcia-Ocaña A, Danial NN Cell reports 25640178 Cell Rep 2015 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/25640178
Acyl hydrazides as peptoid sub-monomers. Sarma BK, Yousufuddin M, Kodadek T Chemical communications (Cambridge, England) 21892506 Chem Commun (Camb) 2011 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/21892506
Proteome-wide covalent ligand discovery in native biological systems. Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF Nature 27309814 Nature 2016 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/27309814
Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF Nature chemical biology 21572424 Nat Chem Biol 2011 May 15 https://www.ncbi.nlm.nih.gov/pubmed/21572424
Quantitative reactivity profiling predicts functional cysteines in proteomes. Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF Nature 21085121 Nature 2010 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/21085121
Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF Journal of the American Chemical Society 22400490 J Am Chem Soc 2012 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/22400490
A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions. Doran TM, Kodadek T ACS chemical biology 24245981 ACS Chem Biol 2014 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/24245981
Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries. Aditya A, Kodadek T ACS combinatorial science 22320121 ACS Comb Sci 2012 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/22320121
Fully functionalized small-molecule probes for integrated phenotypic screening and target identification. Cisar JS, Cravatt BF Journal of the American Chemical Society 22667687 J Am Chem Soc 2012 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/22667687
Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9. Liu X, Dix M, Speers AE, Bachovchin DA, Zuhl AM, Cravatt BF, Kodadek TJ Chembiochem : a European journal of chemical biology 22907802 Chembiochem 2012 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/22907802
Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides. Sarma BK, Liu X, Wu H, Gao Y, Kodadek T Organic & biomolecular chemistry 25354697 Org Biomol Chem 2015 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/25354697
Enzyme inhibitor discovery by activity-based protein profiling. Niphakis MJ, Cravatt BF Annual review of biochemistry 24905785 Annu Rev Biochem 2014 https://www.ncbi.nlm.nih.gov/pubmed/24905785
A Cleavable Scaffold Strategy for the Synthesis of One-Bead One-Compound Cyclic Peptoid Libraries That Can Be Sequenced By Tandem Mass Spectrometry. Simpson LS, Kodadek T Tetrahedron letters 22736872 Tetrahedron Lett 2012 May 2 https://www.ncbi.nlm.nih.gov/pubmed/22736872
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. Johnson DS, Weerapana E, Cravatt BF Future medicinal chemistry 20640225 Future Med Chem 2010 Jun https://www.ncbi.nlm.nih.gov/pubmed/20640225
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF Proceedings of the National Academy of Sciences of the United States of America 21084632 Proc Natl Acad Sci U S A 2010 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/21084632
The pharmacological landscape and therapeutic potential of serine hydrolases. Bachovchin DA, Cravatt BF Nature reviews. Drug discovery 22212679 Nat Rev Drug Discov 2012 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/22212679
Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library. Sarma BK, Liu X, Kodadek T Bioorganic & medicinal chemistry 27160052 Bioorg Med Chem 2016 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/27160052
miRNA goes nuclear. Huang V, Li LC RNA biology 22336708 RNA Biol 2012 Mar https://www.ncbi.nlm.nih.gov/pubmed/22336708
Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth. Ren S, Kang MR, Wang J, Huang V, Place RF, Sun Y, Li LC The Prostate 23836514 Prostate 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23836514
Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression. Place RF, Wang J, Noonan EJ, Meyers R, Manoharan M, Charisse K, Duncan R, Huang V, Wang X, Li LC Molecular therapy. Nucleic acids 23343884 Mol Ther Nucleic Acids 2012 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/23343884
Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation. Wang X, Wang J, Huang V, Place RF, Li LC The Biochemical journal 22339500 Biochem J 2012 May 1 https://www.ncbi.nlm.nih.gov/pubmed/22339500
Epistatic relationships reveal the functional organization of yeast transcription factors. Zheng J, Benschop JJ, Shales M, Kemmeren P, Greenblatt J, Cagney G, Holstege F, Li H, Krogan NJ Molecular systems biology 20959818 Mol Syst Biol 2010 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/20959818
Identification of small activating RNAs that enhance endogenous OCT4 expression in human mesenchymal stem cells. Wang J, Huang V, Ye L, Bárcena A, Lin G, Lue TF, Li LC Stem cells and development 25232932 Stem Cells Dev 2015 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/25232932
RNAa in action: from the exception to the norm. Guo D, Barry L, Lin SS, Huang V, Li LC RNA biology 25602906 RNA Biol 2014 https://www.ncbi.nlm.nih.gov/pubmed/25602906
Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration. Wang J, Place RF, Huang V, Wang X, Noonan EJ, Magyar CE, Huang J, Li LC Cancer research 21159640 Cancer Res 2010 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/21159640
saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Portnoy V, Lin SH, Li KH, Burlingame A, Hu ZH, Li H, Li LC Cell research 26902284 Cell Res 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26902284
Adaptation and clonal selection models of castration-resistant prostate cancer: current perspective. Ahmed M, Li LC International journal of urology : official journal of the Japanese Urological Association 23163774 Int J Urol 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23163774
Upregulation of Cyclin B1 by miRNA and its implications in cancer. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC Nucleic acids research 22053081 Nucleic Acids Res 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22053081
Axial plane single-molecule super-resolution microscopy of whole cells. An S, Ziegler KF, Zhang P, Wang Y, Kwok T, Xu F, Bi C, Matosevic S, Yin P, Li T, Huang F Biomedical optics express 32010528 Biomed Opt Express 2020 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/32010528
Three-dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval. Xu F, Ma D, MacPherson KP, Liu S, Bu Y, Wang Y, Tang Y, Bi C, Kwok T, Chubykin AA, Yin P, Calve S, Landreth GE, Huang F Nature methods 32371980 Nat Methods 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32371980
A Compact DNA Cube with Side Length 10 nm. Scheible MB, Ong LL, Woehrstein JB, Jungmann R, Yin P, Simmel FC Small (Weinheim an der Bergstrasse, Germany) 26294348 Small 2015 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/26294348
Complex cellular logic computation using ribocomputing devices. Green AA, Kim J, Ma D, Silver PA, Collins JJ, Yin P Nature 28746304 Nature 2017 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/28746304
Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components. Ong LL, Hanikel N, Yaghi OK, Grun C, Strauss MT, Bron P, Lai-Kee-Him J, Schueder F, Wang B, Wang P, Kishi JY, Myhrvold C, Zhu A, Jungmann R, Bellot G, Ke Y, Yin P Nature 29219968 Nature 2017 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/29219968
Ribocomputing: Cellular Logic Computation Using RNA Devices. Kim J, Yin P, Green AA Biochemistry 29256603 Biochemistry 2018 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/29256603
Reconfigurable Three-Dimensional Gold Nanorod Plasmonic Nanostructures Organized on DNA Origami Tripod. Zhan P, Dutta PK, Wang P, Song G, Dai M, Zhao SX, Wang ZG, Yin P, Zhang W, Ding B, Ke Y ACS nano 28056172 ACS Nano 2017 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/28056172
Toehold switches: de-novo-designed regulators of gene expression. Green AA, Silver PA, Collins JJ, Yin P Cell 25417166 Cell 2014 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/25417166
Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes. Beliveau BJ, Boettiger AN, Avendaño MS, Jungmann R, McCole RB, Joyce EF, Kim-Kiselak C, Bantignies F, Fonseka CY, Erceg J, Hannan MA, Hoang HG, Colognori D, Lee JT, Shih WM, Yin P, Zhuang X, Wu CT Nature communications 25962338 Nat Commun 2015 May 12 https://www.ncbi.nlm.nih.gov/pubmed/25962338
Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT. Jungmann R, Avendaño MS, Woehrstein JB, Dai M, Shih WM, Yin P Nature methods 24487583 Nat Methods 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24487583
The emerging landscape of single-molecule protein sequencing technologies. Alfaro JA, Bohländer P, Dai M, Filius M, Howard CJ, van Kooten XF, Ohayon S, Pomorski A, Schmid S, Aksimentiev A, Anslyn EV, Bedran G, Cao C, Chinappi M, Coyaud E, Dekker C, Dittmar G, Drachman N, Eelkema R, Goodlett D, Hentz S, Kalathiya U, Kelleher NL, Kelly RT, Kelman Z, Kim SH, Kuster B, Rodriguez-Larrea D, Lindsay S, Maglia G, Marcotte EM, Marino JP, Masselon C, Mayer M, Samaras P, Sarthak K, Sepiashvili L, Stein D, Wanunu M, Wilhelm M, Yin P, Meller A, Joo C Nature methods 34099939 Nat Methods 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34099939
Polyhedra self-assembled from DNA tripods and characterized with 3D DNA-PAINT. Iinuma R, Ke Y, Jungmann R, Schlichthaerle T, Woehrstein JB, Yin P Science (New York, N.Y.) 24625926 Science 2014 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/24625926
Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane. Werbin JL, Avendaño MS, Becker V, Jungmann R, Yin P, Danuser G, Sorger PK Scientific reports 28939861 Sci Rep 2017 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/28939861
Super-resolution Geometric Barcoding for Multiplexed miRNA Profiling. Xu W, Yin P, Dai M Angewandte Chemie (International ed. in English) 30182521 Angew Chem Int Ed Engl 2018 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/30182521
Programmable autonomous synthesis of single-stranded DNA. Kishi JY, Schaus TE, Gopalkrishnan N, Xuan F, Yin P Nature chemistry 29359755 Nat Chem 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29359755
124-Color Super-resolution Imaging by Engineering DNA-PAINT Blinking Kinetics. Wade OK, Woehrstein JB, Nickels PC, Strauss S, Stehr F, Stein J, Schueder F, Strauss MT, Ganji M, Schnitzbauer J, Grabmayr H, Yin P, Schwille P, Jungmann R Nano letters 30864449 Nano Lett 2019 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/30864449
Design space for complex DNA structures. Wei B, Dai M, Myhrvold C, Ke Y, Jungmann R, Yin P Journal of the American Chemical Society 24256506 J Am Chem Soc 2013 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/24256506
Quantitative super-resolution imaging with qPAINT. Jungmann R, Avendaño MS, Dai M, Woehrstein JB, Agasti SS, Feiger Z, Rodal A, Yin P Nature methods 27018580 Nat Methods 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27018580
Optical imaging of individual biomolecules in densely packed clusters. Dai M, Jungmann R, Yin P Nature nanotechnology 27376244 Nat Nanotechnol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27376244
Universal Super-Resolution Multiplexing by DNA Exchange. Schueder F, Strauss MT, Hoerl D, Schnitzbauer J, Schlichthaerle T, Strauss S, Yin P, Harz H, Leonhardt H, Jungmann R Angewandte Chemie (International ed. in English) 28256790 Angew Chem Int Ed Engl 2017 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/28256790
Sub-100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA. Woehrstein JB, Strauss MT, Ong LL, Wei B, Zhang DY, Jungmann R, Yin P Science advances 28691083 Sci Adv 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28691083
Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Song W, Filonov GS, Kim H, Hirsch M, Li X, Moon JD, Jaffrey SR Nature chemical biology 28945233 Nat Chem Biol 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28945233
Multiplexed 3D super-resolution imaging of whole cells using spinning disk confocal microscopy and DNA-PAINT. Schueder F, Lara-Gutiérrez J, Beliveau BJ, Saka SK, Sasaki HM, Woehrstein JB, Strauss MT, Grabmayr H, Yin P, Jungmann R Nature communications 29233999 Nat Commun 2017 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/29233999
Super-resolution labelling with Action-PAINT. Liu N, Dai M, Saka SK, Yin P Nature chemistry 31527848 Nat Chem 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31527848
DNA-barcoded labeling probes for highly multiplexed Exchange-PAINT imaging. Agasti SS, Wang Y, Schueder F, Sukumar A, Jungmann R, Yin P Chemical science 28451377 Chem Sci 2017 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/28451377
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia. Wisniewski NA, Nichols SP, Gamsey SJ, Pullins S, Au-Yeung KY, Klitzman B, Helton KL Advances in experimental medicine and biology 28685468 Adv Exp Med Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28685468
Inorganic-Organic Interpenetrating Network Hydrogels as Tissue-Integrating Luminescent Implants: Physicochemical Characterization and Preclinical Evaluation. Unruh RM, Bornhoeft LR, Nichols SP, Wisniewski NA, McShane MJ Macromolecular bioscience 34847287 Macromol Biosci 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34847287
The First-in-Man "Si Se Puede" Study for the use of micro-oxygen sensors (MOXYs) to determine dynamic relative oxygen indices in the feet of patients with limb-threatening ischemia during endovascular therapy. Montero-Baker MF, Au-Yeung KY, Wisniewski NA, Gamsey S, Morelli-Alvarez L, Mills JL Sr, Campos M, Helton KL Journal of vascular surgery 26004327 J Vasc Surg 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/26004327
Enzymatic Glucose Sensor Compensation for Variations in Ambient Oxygen Concentration. Collier BB, McShane MJ Proceedings of SPIE--the International Society for Optical Engineering 26257458 Proc SPIE Int Soc Opt Eng 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/26257458
Characterization of Lactate Sensors Based on Lactate Oxidase and Palladium Benzoporphyrin Immobilized in Hydrogels. Andrus LP, Unruh R, Wisniewski NA, McShane MJ Biosensors 26198251 Biosensors (Basel) 2015 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/26198251
Temperature Compensation of Oxygen Sensing Films Utilizing a Dynamic Dual Lifetime Calculation Technique. Collier BB, McShane MJ IEEE sensors journal 26566384 IEEE Sens J 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/26566384
A Design Full of Holes: Functional Nanofilm-Coated Microdomains in Alginate Hydrogels. Roberts JR, Ritter DW, McShane MJ Journal of materials chemistry. B 24040514 J Mater Chem B 2013 https://www.ncbi.nlm.nih.gov/pubmed/24040514
Long-Term In Vivo Oxygen Sensors for Peripheral Artery Disease Monitoring. Nichols SP, Balaconis MK, Gant RM, Au-Yeung KY, Wisniewski NA Advances in experimental medicine and biology 30178370 Adv Exp Med Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30178370
A Versatile Multichannel Instrument for Measurement of Ratiometric Fluorescence Intensity and Phosphorescence Lifetime. Zavareh AT, Ko B, Roberts J, Elahi S, McShane MJ IEEE access : practical innovations, open solutions 34858770 IEEE Access 2021 https://www.ncbi.nlm.nih.gov/pubmed/34858770
Preclinical Evaluation of Poly(HEMA-co-acrylamide) Hydrogels Encapsulating Glucose Oxidase and Palladium Benzoporphyrin as Fully Implantable Glucose Sensors. Unruh RM, Roberts JR, Nichols SP, Gamsey S, Wisniewski NA, McShane MJ Journal of diabetes science and technology 26085565 J Diabetes Sci Technol 2015 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/26085565
Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers. Kanick SC, Schneider PA, Klitzman B, Wisniewski NA, Rebrin K Microvascular research 30742844 Microvasc Res 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30742844
Modification of PEGylated enzyme with glutaraldehyde can enhance stability while avoiding intermolecular crosslinking. Ritter DW, Newton JM, McShane MJ RSC advances 26052433 RSC Adv 2014 https://www.ncbi.nlm.nih.gov/pubmed/26052433
Composite Hydrogels with Engineered Microdomains for Optical Glucose Sensing at Low Oxygen Conditions. Bornhoeft LR, Biswas A, McShane MJ Biosensors 28117762 Biosensors (Basel) 2017 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/28117762
Near-Infrared Optical Nanosensors for Continuous Detection of Glucose. Le LV, Chendke GS, Gamsey S, Wisniewski N, Desai TA Journal of diabetes science and technology 31709808 J Diabetes Sci Technol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31709808
Imaging bacterial protein expression using genetically encoded RNA sensors. Song W, Strack RL, Jaffrey SR Nature methods 23872791 Nat Methods 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23872791
Plug-and-play fluorophores extend the spectral properties of Spinach. Song W, Strack RL, Svensen N, Jaffrey SR Journal of the American Chemical Society 24393009 J Am Chem Soc 2014 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/24393009
Fluorescence imaging of cellular metabolites with RNA. Paige JS, Nguyen-Duc T, Song W, Jaffrey SR Science (New York, N.Y.) 22403384 Science 2012 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/22403384
Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator. You M, Litke JL, Wu R, Jaffrey SR Cell chemical biology 30773480 Cell Chem Biol 2019 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/30773480
Rapid Selection of RNA Aptamers that Activate Fluorescence of Small Molecules. Filonov GS Methods in molecular biology (Clifton, N.J.) 28255887 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28255887
Designing optogenetically controlled RNA for regulating biological systems. You M, Jaffrey SR Annals of the New York Academy of Sciences 25758022 Ann N Y Acad Sci 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/25758022
RNA Imaging with Dimeric Broccoli in Live Bacterial and Mammalian Cells. Filonov GS, Jaffrey SR Current protocols in chemical biology 26995352 Curr Protoc Chem Biol 2016 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/26995352
Developing Fluorogenic Riboswitches for Imaging Metabolite Concentration Dynamics in Bacterial Cells. Litke JL, You M, Jaffrey SR Methods in enzymology 27241761 Methods Enzymol 2016 https://www.ncbi.nlm.nih.gov/pubmed/27241761
Structure and Mechanism of RNA Mimics of Green Fluorescent Protein. You M, Jaffrey SR Annual review of biophysics 26098513 Annu Rev Biophys 2015 https://www.ncbi.nlm.nih.gov/pubmed/26098513
New approaches for sensing metabolites and proteins in live cells using RNA. Strack RL, Jaffrey SR Current opinion in chemical biology 23746618 Curr Opin Chem Biol 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23746618
Spectral Tuning by a Single Nucleotide Controls the Fluorescence Properties of a Fluorogenic Aptamer. Filonov GS, Song W, Jaffrey SR Biochemistry 30838859 Biochemistry 2019 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/30838859
Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis. Wang Y, Li Q, Tao B, Angelini M, Ramadoss S, Sun B, Wang P, Krokhaleva Y, Ma F, Gu Y, Espinoza A, Yamauchi K, Pellegrini M, Novitch B, Olcese R, Qu Z, Song Z, Deb A Science (New York, N.Y.) 37769108 Science 2023 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/37769108
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. Cambou MC, Liu CM, Mok T, Fajardo-Martinez V, Paiola SG, Ibarrondo FJ, Kerin T, Fuller T, Tobin NH, Garcia G, Bhattacharya D, Aldrovandi GM, Arumugaswami V, Foo SS, Jung JU, Vasconcelos Z, Brasil P, Brendolin M, Yang OO, Rao R, Nielsen-Saines K The Journal of infectious diseases 36082433 J Infect Dis 2023 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/36082433
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS Proceedings of the National Academy of Sciences of the United States of America 34593624 Proc Natl Acad Sci U S A 2021 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/34593624
Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses. Garcia G Jr, Irudayam JI, Jeyachandran AV, Dubey S, Chang C, Cario SC, Price N, Arumugam S, Marquez AL, Shah A, Fanaei A, Chakravarty N, Joshi S, Sinha S, French SW, Parcells M, Ramaiah A, Arumugaswami V bioRxiv : the preprint server for biology 36711787 bioRxiv 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36711787
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G Jr, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS Nature communications 37185252 Nat Commun 2023 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/37185252
Envelope protein-specific B cell receptors direct lentiviral vector tropism in vivo. Takano KA, Wong AAL, Brown R, Situ K, Chua BA, Abu AE, Pham TT, Reyes GC, Ramachandran S, Kamata M, Li MMH, Wu TT, Rao DS, Arumugaswami V, Dorshkind K, Cole S, Morizono K Molecular therapy : the journal of the American Society of Gene Therapy 38449314 Mol Ther 2024 May 1 https://www.ncbi.nlm.nih.gov/pubmed/38449314
B Cell Receptor's function in virus entry: Anti-SARS-CoV-2 B cell receptors can mediate viral entry in an ACE2-independent mechanism. Larios R, Hossain MB, Brown R, Jeyachandran AV, Abu AE, Zaiss AK, Ramirez CM, Kamata M, Cole S, Wu TT, Dorshkind K, Arumugaswami V, Morizono K PLoS pathogens 41650176 PLoS Pathog 2026 Feb https://www.ncbi.nlm.nih.gov/pubmed/41650176
Proximity labeling in mammalian cells with TurboID and split-TurboID. Cho KF, Branon TC, Udeshi ND, Myers SA, Carr SA, Ting AY Nature protocols 33139955 Nat Protoc 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33139955
RNA-protein interaction mapping via MS2- or Cas13-based APEX targeting. Han S, Zhao BS, Myers SA, Carr SA, He C, Ting AY Proceedings of the National Academy of Sciences of the United States of America 32839320 Proc Natl Acad Sci U S A 2020 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/32839320
Coordination of tumor growth and host wasting by tumor-derived Upd3. Ding G, Xiang X, Hu Y, Xiao G, Chen Y, Binari R, Comjean A, Li J, Rushworth E, Fu Z, Mohr SE, Perrimon N, Song W Cell reports 34407411 Cell Rep 2021 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/34407411
A genetic model for in vivo proximity labelling of the mammalian secretome. Yang R, Meyer AS, Droujinine IA, Udeshi ND, Hu Y, Guo J, McMahon JA, Carey DK, Xu C, Fang Q, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP Open biology 35946312 Open Biol 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35946312
Proximal tubule responses to injury: interrogation by single-cell transcriptomics. Cippà PE, McMahon AP Current opinion in nephrology and hypertension 37074682 Curr Opin Nephrol Hypertens 2023 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/37074682
Protein phosphatase 1 regulates core PCP signaling. Song S, Cho B, Weiner AT, Nissen SB, Naharros IO, Bosch PS, Suyama K, Hu Y, He L, Svinkina T, Udeshi ND, Carr SA, Perrimon N, Axelrod JD bioRxiv : the preprint server for biology 37745534 bioRxiv 2023 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/37745534
Cell-death induced immune response and coagulopathy promote cachexia in Drosophila. Singh A, Hu Y, Lopes RF, Lane L, Woldemichael H, Xu C, Udeshi ND, Carr SA, Perrimon N bioRxiv : the preprint server for biology 39829769 bioRxiv 2025 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/39829769
Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching. Xu C, Li Z, Lyu C, Hu Y, McLaughlin CN, Wong KKL, Xie Q, Luginbuhl DJ, Li H, Udeshi ND, Svinkina T, Mani DR, Han S, Li T, Li Y, Guajardo R, Ting AY, Carr SA, Li J, Luo L Cell 38996528 Cell 2024 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/38996528
Repairing the blood-brain barrier. McMahon AP, Ichida JK Science (New York, N.Y.) 35175806 Science 2022 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/35175806
Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators. Li J, Han S, Li H, Udeshi ND, Svinkina T, Mani DR, Xu C, Guajardo R, Xie Q, Li T, Luginbuhl DJ, Wu B, McLaughlin CN, Xie A, Kaewsapsak P, Quake SR, Carr SA, Ting AY, Luo L Cell 31955847 Cell 2020 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/31955847
Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery. Qin W, Myers SA, Carey DK, Carr SA, Ting AY Nature communications 34404792 Nat Commun 2021 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/34404792
Proteomics of protein trafficking by in vivo tissue-specific labeling. Droujinine IA, Meyer AS, Wang D, Udeshi ND, Hu Y, Rocco D, McMahon JA, Yang R, Guo J, Mu L, Carey DK, Svinkina T, Zeng R, Branon T, Tabatabai A, Bosch JA, Asara JM, Ting AY, Carr SA, McMahon AP, Perrimon N Nature communications 33888706 Nat Commun 2021 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/33888706
Identifying Common Molecular Mechanisms in Experimental and Human Acute Kidney Injury. Gerhardt LMS, McMahon AP Seminars in nephrology 36402654 Semin Nephrol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/36402654
Dynamic mapping of proteome trafficking within and between living cells by TransitID. Qin W, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY Cell 37385249 Cell 2023 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/37385249
Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells. Lee SY, Cheah JS, Zhao B, Xu C, Roh H, Kim CK, Cho KF, Udeshi ND, Carr SA, Ting AY Nature methods 37188954 Nat Methods 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37188954
Split-TurboID enables contact-dependent proximity labeling in cells. Cho KF, Branon TC, Rajeev S, Svinkina T, Udeshi ND, Thoudam T, Kwak C, Rhee HW, Lee IK, Carr SA, Ting AY Proceedings of the National Academy of Sciences of the United States of America 32424107 Proc Natl Acad Sci U S A 2020 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/32424107
Proximity-dependent labeling methods for proteomic profiling in living cells: An update. Bosch JA, Chen CL, Perrimon N Wiley interdisciplinary reviews. Developmental biology 32909689 Wiley Interdiscip Rev Dev Biol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32909689
Regulation of insulin and adipokinetic hormone/glucagon production in flies. Ahmad M, He L, Perrimon N Wiley interdisciplinary reviews. Developmental biology 31379062 Wiley Interdiscip Rev Dev Biol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31379062
In situ cell-type-specific cell-surface proteomic profiling in mice. Shuster SA, Li J, Chon U, Sinantha-Hu MC, Luginbuhl DJ, Udeshi ND, Carey DK, Takeo YH, Xie Q, Xu C, Mani DR, Han S, Ting AY, Carr SA, Luo L Neuron 36220098 Neuron 2022 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/36220098
Dietary Amino Acids Promote Glucagon-like Hormone Release to Generate Novel Calcium Waves in Adipose Tissues. He L, Ahmad M, Wu S, Luo S, Shi W, Guo X, Cao Y, Perrimon N Research square 38947048 Res Sq 2024 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/38947048
Sex and Depot Specific Adipocyte Proteome Profiling In Vivo via Intracellular Proximity Labeling. Simonian TL, Meyer AS, Guo J, Sha J, Wohlschlegel JA, Droujinine IA, Perrimon N, McMahon AP Comprehensive Physiology 40181252 Compr Physiol 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/40181252
Deciphering molecular interactions by proximity labeling. Qin W, Cho KF, Cavanagh PE, Ting AY Nature methods 33432242 Nat Methods 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33432242
Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization. Sanchez AD, Branon TC, Cote LE, Papagiannakis A, Liang X, Pickett MA, Shen K, Jacobs-Wagner C, Ting AY, Feldman JL Current biology : CB 34242576 Curr Biol 2021 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/34242576
Shared and Distinctive Neighborhoods of Emerin and Lamin B Receptor Revealed by Proximity Labeling and Quantitative Proteomics. Cheng LC, Zhang X, Abhinav K, Nguyen JA, Baboo S, Martinez-Bartolomé S, Branon TC, Ting AY, Loose E, Yates JR 3rd, Gerace L Journal of proteome research 35972904 J Proteome Res 2022 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/35972904
Proximity-Labeling Reveals Novel Host and Parasite Proteins at the Toxoplasma Parasitophorous Vacuole Membrane. Cygan AM, Jean Beltran PM, Mendoza AG, Branon TC, Ting AY, Carr SA, Boothroyd JC mBio 34749525 mBio 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34749525
Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code. Xie Q, Li J, Li H, Udeshi ND, Svinkina T, Orlin D, Kohani S, Guajardo R, Mani DR, Xu C, Li T, Han S, Wei W, Shuster SA, Luginbuhl DJ, Quake SR, Murthy SE, Ting AY, Carr SA, Luo L Neuron 35613619 Neuron 2022 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/35613619
Protein phosphatase 1 regulates core PCP signaling. Song S, Cho B, Weiner AT, Nissen SB, Ojeda Naharros I, Sanchez Bosch P, Suyama K, Hu Y, He L, Svinkina T, Udeshi ND, Carr SA, Perrimon N, Axelrod JD EMBO reports 37975164 EMBO Rep 2023 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/37975164
Taf2 mediates DNA binding of Taf14. Klein BJ, Feigerle JT, Zhang J, Ebmeier CC, Fan L, Singh RK, Wang WW, Schmitt LR, Lee T, Hansen KC, Liu WR, Wang YX, Strahl BD, Anthony Weil P, Kutateladze TG Nature communications 35676274 Nat Commun 2022 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/35676274
Structure of mitotic chromosomes. Beel AJ, Azubel M, Matteï PJ, Kornberg RD Molecular cell 34520722 Mol Cell 2021 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/34520722
Gold nanoparticles and tilt pairs to assess protein flexibility by cryo-electron microscopy. Jagota M, Townshend RJL, Kang LW, Bushnell DA, Dror RO, Kornberg RD, Azubel M Ultramicroscopy 34062386 Ultramicroscopy 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34062386
3D genomics across the tree of life reveals condensin II as a determinant of architecture type. Hoencamp C, Dudchenko O, Elbatsh AMO, Brahmachari S, Raaijmakers JA, van Schaik T, Sedeño Cacciatore Á, Contessoto VG, van Heesbeen RGHP, van den Broek B, Mhaskar AN, Teunissen H, St Hilaire BG, Weisz D, Omer AD, Pham M, Colaric Z, Yang Z, Rao SSP, Mitra N, Lui C, Yao W, Khan R, Moroz LL, Kohn A, St Leger J, Mena A, Holcroft K, Gambetta MC, Lim F, Farley E, Stein N, Haddad A, Chauss D, Mutlu AS, Wang MC, Young ND, Hildebrandt E, Cheng HH, Knight CJ, Burnham TLU, Hovel KA, Beel AJ, Mattei PJ, Kornberg RD, Warren WC, Cary G, Gómez-Skarmeta JL, Hinman V, Lindblad-Toh K, Di Palma F, Maeshima K, Multani AS, Pathak S, Nel-Themaat L, Behringer RR, Kaur P, Medema RH, van Steensel B, de Wit E, Onuchic JN, Di Pierro M, Lieberman Aiden E, Rowland BD Science (New York, N.Y.) 34045355 Science 2021 May 28 https://www.ncbi.nlm.nih.gov/pubmed/34045355
Primary Role of the Nucleosome. Kornberg RD, Lorch Y Molecular cell 32763226 Mol Cell 2020 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/32763226
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator. Sanborn AL, Yeh BT, Feigerle JT, Hao CV, Townshend RJ, Lieberman Aiden E, Dror RO, Kornberg RD eLife 33904398 Elife 2021 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/33904398
Gut macrophages: key players in intestinal immunity and tissue physiology. Muller PA, Matheis F, Mucida D Current opinion in immunology 31841704 Curr Opin Immunol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31841704
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes. Bousbaine D, Fisch LI, London M, Bhagchandani P, Rezende de Castro TB, Mimee M, Olesen S, Reis BS, VanInsberghe D, Bortolatto J, Poyet M, Cheloha RW, Sidney J, Ling J, Gupta A, Lu TK, Sette A, Alm EJ, Moon JJ, Victora GD, Mucida D, Ploegh HL, Bilate AM Science (New York, N.Y.) 35926021 Science 2022 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/35926021
Tunable dynamics of B cell selection in gut germinal centres. Nowosad CR, Mesin L, Castro TBR, Wichmann C, Donaldson GP, Araki T, Schiepers A, Lockhart AAK, Bilate AM, Mucida D, Victora GD Nature 33116306 Nature 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33116306
Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss. Matheis F, Muller PA, Graves CL, Gabanyi I, Kerner ZJ, Costa-Borges D, Ahrends T, Rosenstiel P, Mucida D Cell 31923400 Cell 2020 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/31923400
Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections. Ahrends T, Aydin B, Matheis F, Classon CH, Marchildon F, Furtado GC, Lira SA, Mucida D Cell 34717799 Cell 2021 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/34717799
Microbiota-modulated CART(+) enteric neurons autonomously regulate blood glucose. Muller PA, Matheis F, Schneeberger M, Kerner Z, Jové V, Mucida D Science (New York, N.Y.) 32855216 Science 2020 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/32855216
Microbiota modulate sympathetic neurons via a gut-brain circuit. Muller PA, Schneeberger M, Matheis F, Wang P, Kerner Z, Ilanges A, Pellegrino K, Del Mármol J, Castro TBR, Furuichi M, Perkins M, Han W, Rao A, Pickard AJ, Cross JR, Honda K, de Araujo I, Mucida D Nature 32641826 Nature 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32641826
Rationale redesign of type III secretion systems: toward the development of non-pathogenic E. coli for in vivo delivery of therapeutic payloads. González-Prieto C, Lesser CF Current opinion in microbiology 29141238 Curr Opin Microbiol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29141238
Citrobacter rodentium(ϕStx2dact), a murine infection model for enterohemorrhagic Escherichia coli. Thorpe CM, Pulsifer AR, Osburne MS, Vanaja SK, Leong JM Current opinion in microbiology 34929548 Curr Opin Microbiol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34929548
Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917. Gelfat I, Aqeel Y, Tremblay JM, Jaskiewicz JJ, Shrestha A, Lee JN, Hu S, Qian X, Magoun L, Sheoran A, Bedenice D, Giem C, Manjula-Basavanna A, Pulsifer AR, Tu HX, Li X, Minus ML, Osburne MS, Tzipori S, Shoemaker CB, Leong JM, Joshi NS PLoS pathogens 36107831 PLoS Pathog 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36107831
In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli. Srivastava R, González-Prieto C, Lynch JP, Muscolo M, Lin CY, Brown MA, Lemos L, Shrestha A, Osburne MS, Leong JM, Lesser CF bioRxiv : the preprint server for biology 39131305 bioRxiv 2024 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/39131305
Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut. Lynch JP, González-Prieto C, Reeves AZ, Bae S, Powale U, Godbole NP, Tremblay JM, Schmidt FI, Ploegh HL, Kansra V, Glickman JN, Leong JM, Shoemaker CB, Garrett WS, Lesser CF Cell host & microbe 37003258 Cell Host Microbe 2023 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/37003258
In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli. Srivastava R, González-Prieto C, Lynch JP, Muscolo ME, Lin CY, Brown MA, Lemos L, Shrestha A, Osburne MS, Leong JM, Lesser CF PNAS nexus 39262854 PNAS Nexus 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39262854
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics. Lynch JP, Goers L, Lesser CF Trends in pharmacological sciences 35232591 Trends Pharmacol Sci 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35232591
A host metabolite promotes Salmonella survival. Lynch JP, Lesser CF Science (New York, N.Y.) 33479138 Science 2021 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/33479138
Living Engineered Bacterial Therapeutics: Emerging Affordable Precision Interventions. Srivastava R, Lesser CF Microbial biotechnology 39579048 Microb Biotechnol 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39579048
PROT(3)EcT, engineered Escherichia coli for the targeted delivery of therapeutics. González-Prieto C, Lynch JP, Lesser CF Trends in molecular medicine 37574350 Trends Mol Med 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37574350
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways. Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN Cell metabolism 37339634 Cell Metab 2023 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/37339634
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A Journal of the American Chemical Society 32175731 J Am Chem Soc 2020 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/32175731
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform. Lim D, Sreekanth V, Cox KJ, Law BK, Wagner BK, Karp JM, Choudhary A Nature communications 32792475 Nat Commun 2020 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/32792475
Rational Design of Silicon-Based Zinc Ionophores. Yamada K, Deb A, Shoba VM, Lim D, Maji B, Modell AE, Choudhary A Angewandte Chemie (International ed. in English) 35385189 Angew Chem Int Ed Engl 2022 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/35385189
Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python. Andrew AL, Perry BW, Card DC, Schield DR, Ruggiero RP, McGaugh SE, Choudhary A, Secor SM, Castoe TA BMC genomics 28464824 BMC Genomics 2017 May 2 https://www.ncbi.nlm.nih.gov/pubmed/28464824
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells. Yang K, Lee M, Jones PA, Liu SS, Zhou A, Xu J, Sreekanth V, Wu JLY, Vo L, Lee EA, Pop R, Lee Y, Wagner BK, Melton DA, Choudhary A, Karp JM Science advances 33208361 Sci Adv 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33208361
Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking. Speer JE, Gunasekara DB, Wang Y, Fallon JK, Attayek PJ, Smith PC, Sims CE, Allbritton NL Journal of biological engineering 31061676 J Biol Eng 2019 https://www.ncbi.nlm.nih.gov/pubmed/31061676
Reserve Stem Cells in Intestinal Homeostasis and Injury. Bankaitis ED, Ha A, Kuo CJ, Magness ST Gastroenterology 30118745 Gastroenterology 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30118745
Bioengineered Systems and Designer Matrices That Recapitulate the Intestinal Stem Cell Niche. Wang Y, Kim R, Hinman SS, Zwarycz B, Magness ST, Allbritton NL Cellular and molecular gastroenterology and hepatology 29675459 Cell Mol Gastroenterol Hepatol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29675459
In vitro generation of self-renewing human intestinal epithelia over planar and shaped collagen hydrogels. Hinman SS, Wang Y, Kim R, Allbritton NL Nature protocols 33299154 Nat Protoc 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33299154
Magnetically-propelled fecal surrogates for modeling the impact of solid-induced shear forces on primary colonic epithelial cells. Hinman SS, Huling J, Wang Y, Wang H, Bretherton RC, DeForest CA, Allbritton NL Biomaterials 34412014 Biomaterials 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34412014
Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells. Sarma S, Catella CM, Pedro ETS, Xiao X, Durmusoglu D, Menegatti S, Crook N, Magness ST, Hall CK bioRxiv : the preprint server for biology 36711911 bioRxiv 2023 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/36711911
"Fix and Click" for Assay of Sphingolipid Signaling in Single Primary Human Intestinal Epithelial Cells. Gallion LA, Wang Y, Massaro A, Yao M, Petersen BV, Zhang Q, Huang W, Carr AJ, Zhang Q, Allbritton NL Analytical chemistry 35020354 Anal Chem 2022 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/35020354
Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cells. Breau KA, Ok MT, Gomez-Martinez I, Burclaff J, Kohn NP, Magness ST Stem cell reports 35523179 Stem Cell Reports 2022 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/35523179
Preparing Chamber Slides With Pressed Collagen for Live Imaging Monolayers of Primary Human Intestinal Stem Cells. Burclaff J, Magness ST Bio-protocol 39600970 Bio Protoc 2024 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/39600970
TGFB1 induces fetal reprogramming and enhances intestinal regeneration. Chen L, Qiu X, Dupre A, Pellon-Cardenas O, Fan X, Xu X, Rout P, Walton KD, Burclaff J, Zhang R, Fang W, Ofer R, Logerfo A, Vemuri K, Bandyopadhyay S, Wang J, Barbet G, Wang Y, Gao N, Perekatt AO, Hu W, Magness ST, Spence JR, Verzi MP Cell stem cell 37865088 Cell Stem Cell 2023 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/37865088
Integrative microphysiological tissue systems of cancer metastasis to the liver. Clark AM, Allbritton NL, Wells A Seminars in cancer biology 32580025 Semin Cancer Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/32580025
A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies. Gunasekara DB, Speer J, Wang Y, Nguyen DL, Reed MI, Smiddy NM, Parker JS, Fallon JK, Smith PC, Sims CE, Magness ST, Allbritton NL Analytical chemistry 30350627 Anal Chem 2018 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/30350627
Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base. Bultman SJ Translational cancer research 30568890 Transl Cancer Res 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/30568890
In Vitro Generation of Mouse Colon Crypts. Wang Y, Gunasekara DB, Attayek PJ, Reed MI, DiSalvo M, Nguyen DL, Dutton JS, Lebhar MS, Bultman SJ, Sims CE, Magness ST, Allbritton NL ACS biomaterials science & engineering 30854421 ACS Biomater Sci Eng 2017 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/30854421
Recombination drives the evolution of mutational robustness. Singhal S, Gomez SM, Burch CL Current opinion in systems biology 31572829 Curr Opin Syst Biol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/31572829
Building a Thick Mucus Hydrogel Layer to Improve the Physiological Relevance of In Vitro Primary Colonic Epithelial Models. Wang Y, Kim R, Sims CE, Allbritton NL Cellular and molecular gastroenterology and hepatology 31356887 Cell Mol Gastroenterol Hepatol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31356887
An in vitro intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface. Kim R, Attayek PJ, Wang Y, Furtado KL, Tamayo R, Sims CE, Allbritton NL Biofabrication 31519008 Biofabrication 2019 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/31519008
Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells. Wang Y, DiSalvo M, Gunasekara DB, Dutton J, Proctor A, Lebhar MS, Williamson IA, Speer J, Howard RL, Smiddy NM, Bultman SJ, Sims CE, Magness ST, Allbritton NL Cellular and molecular gastroenterology and hepatology 29204504 Cell Mol Gastroenterol Hepatol 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/29204504
Development of Arrayed Colonic Organoids for Screening of Secretagogues Associated with Enterotoxins. Gunasekara DB, DiSalvo M, Wang Y, Nguyen DL, Reed MI, Speer J, Sims CE, Magness ST, Allbritton NL Analytical chemistry 29281259 Anal Chem 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29281259
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure. Ok MT, Liu J, Bliton RJ, Hinesley CM, San Pedro EET, Breau KA, Gomez-Martinez I, Burclaff J, Magness ST American journal of physiology. Gastrointestinal and liver physiology 36749911 Am J Physiol Gastrointest Liver Physiol 2023 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/36749911
In Silico Identification and Experimental Validation of Peptide-Based Inhibitors Targeting Clostridium difficile Toxin A. Xiao X, Sarma S, Menegatti S, Crook N, Magness ST, Hall CK ACS chemical biology 34965093 ACS Chem Biol 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/34965093
Chromatin profiling to identify biomarkers in inflammatory bowel diseases. Awad A, Alcala AJ, Cowles MW, Sheikh SZ Current opinion in gastroenterology 40304726 Curr Opin Gastroenterol 2025 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/40304726
Myeloid Cell Adhesion Molecule 1 (CADM1) Promotes Proinflammatory Signaling in Human Inflammatory Bowel Diseases. Darlington KC, Shumway AJ, Sona C, Khaled Z, Steinbach EC, Kikuchi Y, Fan S, Gartner V, Clough KM, Nishiyama NC, Ng MK, VanLandingham N, Schaner MR, Silverstein S, Lau G, Lian G, Huan B, Zhu LC, Bantumilli S, Furey B, Chaudhry EA, Kapadia MR, Sadiq TS, Barnes EL, Shanahan MT, Rahbar R, Vilen BJ, Bi X, Chen H, Jain D, Akram M, Wong J, Mangada M, Bain G, Nagy ML, Hav M, Ito A, Yan X, Komatsu M, Awad A, Furey TS, Sethupathy P, Poy MN, Sheikh SZ Cellular and molecular gastroenterology and hepatology 40882838 Cell Mol Gastroenterol Hepatol 2026 https://www.ncbi.nlm.nih.gov/pubmed/40882838
Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer. Bultman SJ Molecular nutrition & food research 27138454 Mol Nutr Food Res 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27138454
A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium. Wang Y, Gunasekara DB, Reed MI, DiSalvo M, Bultman SJ, Sims CE, Magness ST, Allbritton NL Biomaterials 28288348 Biomaterials 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28288348
The role of the microbiome in cancer development and therapy. Bhatt AP, Redinbo MR, Bultman SJ CA: a cancer journal for clinicians 28481406 CA Cancer J Clin 2017 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/28481406
Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Tse LV, Meganck RM, Araba KC, Yount BL, Shaffer KM, Hou YJ, Munt JE, Adams LE, Wykoff JA, Morowitz JM, Dong S, Magness ST, Marzluff WF, Gonzalez LM, Ehre C, Baric RS Proceedings of the National Academy of Sciences of the United States of America 35476513 Proc Natl Acad Sci U S A 2022 May 3 https://www.ncbi.nlm.nih.gov/pubmed/35476513
Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. Toyonaga T, Steinbach EC, Keith BP, Barrow JB, Schaner MR, Wolber EA, Beasley C, Huling J, Wang Y, Allbritton NL, Chaumont N, Sadiq TS, Koruda MJ, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Shanahan MT, Rahbar R, Furey TS, Sethupathy P, Sheikh SZ Cellular and molecular gastroenterology and hepatology 32561494 Cell Mol Gastroenterol Hepatol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32561494
Enterochromaffin Cell-Enriched Monolayer Platform for Assaying Serotonin Release from Human Primary Intestinal Cells. Wang Y, Sims CE, Allbritton NL Analytical chemistry 32819098 Anal Chem 2020 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/32819098
Microphysiological System Design: Simplicity Is Elegance. Hinman SS, Kim R, Wang Y, Phillips KS, Attayek PJ, Allbritton NL Current opinion in biomedical engineering 32095672 Curr Opin Biomed Eng 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32095672
Photopatterned Membranes and Chemical Gradients Enable Scalable Phenotypic Organization of Primary Human Colon Epithelial Models. Hinman SS, Wang Y, Allbritton NL Analytical chemistry 31692334 Anal Chem 2019 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/31692334
Evaluation of human primary intestinal monolayers for drug metabolizing capabilities. Speer JE, Wang Y, Fallon JK, Smith PC, Allbritton NL Journal of biological engineering 31709009 J Biol Eng 2019 https://www.ncbi.nlm.nih.gov/pubmed/31709009
Primary Cell-Derived Intestinal Models: Recapitulating Physiology. Dutton JS, Hinman SS, Kim R, Wang Y, Allbritton NL Trends in biotechnology 30591184 Trends Biotechnol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30591184
Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer. Wang Y, Kim R, Gunasekara DB, Reed MI, DiSalvo M, Nguyen DL, Bultman SJ, Sims CE, Magness ST, Allbritton NL Cellular and molecular gastroenterology and hepatology 29693040 Cell Mol Gastroenterol Hepatol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29693040
Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells. Bhatt AP, Gunasekara DB, Speer J, Reed MI, Peña AN, Midkiff BR, Magness ST, Bultman SJ, Allbritton NL, Redinbo MR ACS infectious diseases 29094594 ACS Infect Dis 2018 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/29094594
A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity. Rivera KR, Bliton RJ, Burclaff J, Czerwinski MJ, Liu J, Trueblood JM, Hinesley CM, Breau KA, Joshi S, Pozdin VA, Yao M, Ziegler AL, Blikslager AT, Daniele MA, Magness ST bioRxiv : the preprint server for biology 36778265 bioRxiv 2023 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/36778265
Design of 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells. Sarma S, Catella CM, San Pedro ET, Xiao X, Durmusoglu D, Menegatti S, Crook N, Magness ST, Hall CK Communications biology 37634026 Commun Biol 2023 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/37634026
An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal stem cells. Cotton MJ, Ariel P, Chen K, Walcott VA, Dixit M, Breau KA, Hinesley CM, Kedziora K, Tang CY, Zheng A, Magness ST, Burclaff J bioRxiv : the preprint server for biology 37873351 bioRxiv 2023 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/37873351
Replicating Host-Microbiome Interactions: Harnessing Organ-on-a-Chip and Organoid Technologies to Model Vaginal and Lung Physiology. Coxon J, Linder E, Sweet C, Magness S, Green L Annual review of biomedical engineering 39971348 Annu Rev Biomed Eng 2025 May https://www.ncbi.nlm.nih.gov/pubmed/39971348
Coupling mathematical modeling with a novel human intestinal stem cell system to understand feedback regulation during planar cell polarity. Breau KA, Dunahey EG, Fosnocht HV, Magness ST, Elston TC bioRxiv : the preprint server for biology 41279301 bioRxiv 2025 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/41279301
The microbiome and its potential as a cancer preventive intervention. Bultman SJ Seminars in oncology 26970128 Semin Oncol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26970128
Formation of arrays of planar, murine, intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone. Kim R, Wang Y, Hwang SJ, Attayek PJ, Smiddy NM, Reed MI, Sims CE, Allbritton NL Lab on a chip 29944153 Lab Chip 2018 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/29944153
"Fix and assay": separating in-cellulo sphingolipid reactions from analytical assay in time and space using an aldehyde-based fixative. Proctor A , Allbritton NL The Analyst 30207332 Analyst 2019 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/30207332
Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human-Intestinal-Epithelial-Monolayer Platform. Wang Y, Kim R, Hwang SJ, Dutton J, Sims CE, Allbritton NL Analytical chemistry 30199234 Anal Chem 2018 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/30199234
A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. Williamson IA, Arnold JW, Samsa LA, Gaynor L, DiSalvo M, Cocchiaro JL, Carroll I, Azcarate-Peril MA, Rawls JF, Allbritton NL, Magness ST Cellular and molecular gastroenterology and hepatology 30123820 Cell Mol Gastroenterol Hepatol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30123820
A Planar Culture Model of Human Absorptive Enterocytes Reveals Metformin Increases Fatty Acid Oxidation and Export. Gomez-Martinez I, Bliton RJ, Breau KA, Czerwinski MJ, Williamson IA, Wen J, Rawls JF, Magness ST Cellular and molecular gastroenterology and hepatology 35489715 Cell Mol Gastroenterol Hepatol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35489715
Use of liquid lithography to form in vitro intestinal crypts with varying microcurvature surrounding the stem cell niche. Logan Howard R, Wang Y, Allbritton NL Journal of micromechanics and microengineering : structures, devices, and systems 35241878 J Micromech Microeng 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/35241878
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics. Burclaff J, Bliton RJ, Breau KA, Ok MT, Gomez-Martinez I, Ranek JS, Bhatt AP, Purvis JE, Woosley JT, Magness ST Cellular and molecular gastroenterology and hepatology 35176508 Cell Mol Gastroenterol Hepatol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35176508
Stem/Proliferative and Differentiated Cells within Primary Murine Colonic Epithelium Display Distinct Intracellular Free Ca(2+) Signal Codes. Mestril S, Kim R, Hinman SS, Gomez SM, Allbritton NL Advanced healthcare materials 34510822 Adv Healthc Mater 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34510822
Hyperglycemia minimally alters primary self-renewing human colonic epithelial cells while TNFα-promotes severe intestinal epithelial dysfunction. Dutton JS, Hinman SS, Kim R, Attayek PJ, Maurer M, Sims CS, Allbritton NL Integrative biology : quantitative biosciences from nano to macro 33989405 Integr Biol (Camb) 2021 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/33989405
Kinome state is predictive of cell viability in pancreatic cancer tumor and cancer-associated fibroblast cell lines. Berginski ME, Jenner MR, Joisa CU, Herrera Loeza G, Golitz BT, Lipner MB, Leary JR, Rashid N, Johnson GL, Yeh JJ, Gomez SM PeerJ 39221276 PeerJ 2024 https://www.ncbi.nlm.nih.gov/pubmed/39221276
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity. Rivera KR, Bliton RJ, Burclaff J, Czerwinski MJ, Liu J, Trueblood JM, Hinesley CM, Breau KA, Deal HE, Joshi S, Pozdin VA, Yao M, Ziegler AL, Blikslager AT, Daniele MA, Magness ST Cellular and molecular gastroenterology and hepatology 37562653 Cell Mol Gastroenterol Hepatol 2023 https://www.ncbi.nlm.nih.gov/pubmed/37562653
A TALEN genome-editing system for generating human stem cell-based disease models. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA Cell stem cell 23246482 Cell Stem Cell 2013 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/23246482
Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Veres A, Gosis BS, Ding Q, Collins R, Ragavendran A, Brand H, Erdin S, Cowan CA, Talkowski ME, Musunuru K Cell stem cell 24996167 Cell Stem Cell 2014 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/24996167
Improved vectors and genome-wide libraries for CRISPR screening. Sanjana NE, Shalem O, Zhang F Nature methods 25075903 Nat Methods 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/25075903
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs. Ding Q, Regan SN, Xia Y, Oostrom LA, Cowan CA, Musunuru K Cell stem cell 23561441 Cell Stem Cell 2013 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/23561441
White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Moisan A, Lee YK, Zhang JD, Hudak CS, Meyer CA, Prummer M, Zoffmann S, Truong HH, Ebeling M, Kiialainen A, Gérard R, Xia F, Schinzel RT, Amrein KE, Cowan CA Nature cell biology 25487280 Nat Cell Biol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25487280
Humanity in a Dish: Population Genetics with iPSCs. Warren CR, Cowan CA Trends in cell biology 29054332 Trends Cell Biol 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29054332
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro. Pope BD, Warren CR, Dahl MO, Pizza CV, Henze DE, Sinatra NR, Gonzalez GM, Chang H, Liu Q, Glieberman AL, Ferrier JP Jr, Cowan CA, Parker KK Lab on a chip 33034335 Lab Chip 2020 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/33034335
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA Cell stem cell 32413331 Cell Stem Cell 2020 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/32413331
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA Cell 25748654 Cell 2015 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/25748654
In vivo genome editing using Staphylococcus aureus Cas9. Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F Nature 25830891 Nature 2015 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/25830891
CRISPR-mediated direct mutation of cancer genes in the mouse liver. Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T Nature 25119044 Nature 2014 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/25119044
DNA targeting specificity of RNA-guided Cas9 nucleases. Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F Nature biotechnology 23873081 Nat Biotechnol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23873081
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Ran FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S, Trevino AE, Scott DA, Inoue A, Matoba S, Zhang Y, Zhang F Cell 23992846 Cell 2013 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/23992846
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N Science (New York, N.Y.) 24604203 Science 2014 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/24604203
Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing. Ding Q, Strong A, Patel KM, Ng SL, Gosis BS, Regan SN, Cowan CA, Rader DJ, Musunuru K Circulation research 24916110 Circ Res 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24916110
CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F Cell 25263330 Cell 2014 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/25263330
Minireview: Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease. Yu H, Cowan CA Molecular endocrinology (Baltimore, Md.) 27075706 Mol Endocrinol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27075706
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA Cell stem cell 28388431 Cell Stem Cell 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28388431
Microenvironmental Control of Adipocyte Fate and Function. Pope BD, Warren CR, Parker KK, Cowan CA Trends in cell biology 27268909 Trends Cell Biol 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27268909
Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells. Peters DT, Henderson CA, Warren CR, Friesen M, Xia F, Becker CE, Musunuru K, Cowan CA Development (Cambridge, England) 27143754 Development 2016 May 1 https://www.ncbi.nlm.nih.gov/pubmed/27143754
Prospective functional classification of all possible missense variants in PPARG. Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, Duby M, Sharpe T, Kalkhoven E, Rosen ED, Barroso I, Ellard S, UK Monogenic Diabetes Consortium, Kathiresan S, Myocardial Infarction Genetics Consortium, O'Rahilly S, UK Congenital Lipodystrophy Consortium, Chatterjee K, Florez JC, Mikkelsen T, Savage DB, Altshuler D Nature genetics 27749844 Nat Genet 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27749844
[Leukocyte count of puerperal sows]. Mäde D, Wujanz G Berliner und Munchener tierarztliche Wochenschrift 9054332 Berl Munch Tierarztl Wochenschr 1996 Sep https://www.ncbi.nlm.nih.gov/pubmed/9054332
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum. Wagner JC, Platt RJ, Goldfless SJ, Zhang F, Niles JC Nature methods 25108687 Nat Methods 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25108687
Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report. Gupta RM, Meissner TB, Cowan CA, Musunuru K Arteriosclerosis, thrombosis, and vascular biology 26543098 Arterioscler Thromb Vasc Biol 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26543098
A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL Proceedings of the National Academy of Sciences of the United States of America 27078102 Proc Natl Acad Sci U S A 2016 May 10 https://www.ncbi.nlm.nih.gov/pubmed/27078102
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA Nature biotechnology 24752079 Nat Biotechnol 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24752079
Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, Rossi DJ, Cowan CA Cell stem cell 25517468 Cell Stem Cell 2014 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/25517468
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F, Ferreira LMR, Chen Z, Chen T, Loaiza N, Horwitz NB, Kacergis MC, Zhao L, BIOS Consortium, Soukas AA, Kuivenhoven JA, Kathiresan S, Cowan CA Cell 31778654 Cell 2019 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/31778654
A Pungent and Painful Toxin. Green D, Dong X Cell 31474364 Cell 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/31474364
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgård PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA Nature cell biology 26214132 Nat Cell Biol 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26214132
Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions. Hendriks WT, Warren CR, Cowan CA Cell stem cell 26748756 Cell Stem Cell 2016 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/26748756
Genome-scale CRISPR-Cas9 knockout screening in human cells. Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F Science (New York, N.Y.) 24336571 Science 2014 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/24336571
Genome engineering using the CRISPR-Cas9 system. Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F Nature protocols 24157548 Nat Protoc 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24157548
Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes. Friesen M, Warren CR, Yu H, Toyohara T, Ding Q, Florido MHC, Sayre C, Pope BD, Goff LA, Rinn JL, Cowan CA Stem cell reports 32243843 Stem Cell Reports 2020 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/32243843
The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans. Zheng M, Zhang H, Dill DL, Clark JD, Tu S, Yablonovitch AL, Tan MH, Zhang R, Rujescu D, Wu M, Tessarollo L, Vieira W, Gottesman MM, Deng S, Eberlin LS, Zare RN, Billard JM, Gillet JP, Li JB, Peltz G PLoS medicine 25647612 PLoS Med 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25647612
Liquid chromatography/mass spectrometry methods for measuring dipeptide abundance in non-small-cell lung cancer. Wu M, Xu Y, Fitch WL, Zheng M, Merritt RE, Shrager JB, Zhang W, Dill DL, Peltz G, Hoang CD Rapid communications in mass spectrometry : RCM 23943330 Rapid Commun Mass Spectrom 2013 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/23943330
Cd14 SNPs regulate the innate immune response. Liu HH, Hu Y, Zheng M, Suhoski MM, Engleman EG, Dill DL, Hudnall M, Wang J, Spolski R, Leonard WJ, Peltz G Molecular immunology 22445606 Mol Immunol 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22445606
A better prognosis for genetic association studies in mice. Zheng M, Dill D, Peltz G Trends in genetics : TIG 22118772 Trends Genet 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22118772
Opiate-induced changes in brain adenosine levels and narcotic drug responses. Wu M, Sahbaie P, Zheng M, Lobato R, Boison D, Clark JD, Peltz G Neuroscience 23098802 Neuroscience 2013 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/23098802
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H Biochemical and biophysical research communications 21238430 Biochem Biophys Res Commun 2011 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/21238430
Identification of drug targets by chemogenomic and metabolomic profiling in yeast. Wu M, Zheng M, Zhang W, Suresh S, Schlecht U, Fitch WL, Aronova S, Baumann S, Davis R, St Onge R, Dill DL, Peltz G Pharmacogenetics and genomics 23076370 Pharmacogenet Genomics 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/23076370
Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine. Park WG, Wu M, Bowen R, Zheng M, Fitch WL, Pai RK, Wodziak D, Visser BC, Poultsides GA, Norton JA, Banerjee S, Chen AM, Friedland S, Scott BA, Pasricha PJ, Lowe AW, Peltz G Gastrointestinal endoscopy 23566642 Gastrointest Endosc 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23566642
Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G The Journal of pharmacology and experimental therapeutics 23143674 J Pharmacol Exp Ther 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23143674
Computational genetic discoveries that could improve perioperative medicine. Zheng M, Dill D, Clark JD, Peltz G Current opinion in anaesthesiology 22647490 Curr Opin Anaesthesiol 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22647490
Can 'humanized' mice improve drug development in the 21st century? Peltz G Trends in pharmacological sciences 23602782 Trends Pharmacol Sci 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23602782
Next-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection. Peltz G, Zaas AK, Zheng M, Solis NV, Zhang MX, Liu HH, Hu Y, Boxx GM, Phan QT, Dill D, Filler SG Infection and immunity 21875959 Infect Immun 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21875959
The impact of Helicobacter pylori on atopic disorders in childhood. Holster IL, Vila AM, Caudri D, den Hoed CM, Perez-Perez GI, Blaser MJ, de Jongste JC, Kuipers EJ Helicobacter 22515362 Helicobacter 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22515362
Are we using too many antibiotics during pregnancy? Ledger WJ, Blaser MJ BJOG : an international journal of obstetrics and gynaecology 24118809 BJOG 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24118809
Antibiotic exposure and the development of coeliac disease: a nationwide case-control study. Mårild K, Ye W, Lebwohl B, Green PH, Blaser MJ, Card T, Ludvigsson JF BMC gastroenterology 23834758 BMC Gastroenterol 2013 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/23834758
Association between Helicobacter pylori and mortality in the NHANES III study. Chen Y, Segers S, Blaser MJ Gut 23303440 Gut 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23303440
Distinct cutaneous bacterial assemblages in a sampling of South American Amerindians and US residents. Blaser MJ, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Estrada I, Gao Z, Clemente JC, Costello EK, Knight R The ISME journal 22895161 ISME J 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/22895161
Antibiotics in early life alter the murine colonic microbiome and adiposity. Cho I, Yamanishi S, Cox L, Methé BA, Zavadil J, Li K, Gao Z, Mahana D, Raju K, Teitler I, Li H, Alekseyenko AV, Blaser MJ Nature 22914093 Nature 2012 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/22914093
Association of caesarean delivery with child adiposity from age 6 weeks to 15 years. Blustein J, Attina T, Liu M, Ryan AM, Cox LM, Blaser MJ, Trasande L International journal of obesity (2005) 23670220 Int J Obes (Lond) 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23670220
The microbiome revolution. Blaser MJ The Journal of clinical investigation 25271724 J Clin Invest 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25271724
A bitter aftertaste: unintended effects of artificial sweeteners on the gut microbiome. Bokulich NA, Blaser MJ Cell metabolism 25440050 Cell Metab 2014 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/25440050
Enteric hyperoxaluria: role of microbiota and antibiotics. Liu M, Nazzal L Current opinion in nephrology and hypertension 31145706 Curr Opin Nephrol Hypertens 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31145706
The Role of CagA in the Gastric Biology of Helicobacter pylori. Backert S, Blaser MJ Cancer research 27655809 Cancer Res 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27655809
The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial. Walker JM, Eckardt P, Aleman JO, da Rosa JC, Liang Y, Iizumi T, Etheve S, Blaser MJ, L Breslow J, Holt PR Journal of clinical and translational research 30873501 J Clin Transl Res 2019 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/30873501
Estimating and testing the microbial causal mediation effect with high-dimensional and compositional microbiome data. Wang C, Hu J, Blaser MJ, Li H Bioinformatics (Oxford, England) 31329243 Bioinformatics 2020 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/31329243
The gut microbiota influences skeletal muscle mass and function in mice. Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, Cox LM, Selkrig J, Posma JM, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser MJ, Auwerx J, Holmes E, Nicholson J, Wahli W, Pettersson S Science translational medicine 31341063 Sci Transl Med 2019 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/31341063
Comparative prevalence of Oxalobacter formigenes in three human populations. PeBenito A, Nazzal L, Wang C, Li H, Jay M, Noya-Alarcon O, Contreras M, Lander O, Leach J, Dominguez-Bello MG, Blaser MJ Scientific reports 30679485 Sci Rep 2019 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/30679485
Helicobacter pylori lipids can form ordered membrane domains (rafts). Huang Z, Zhang XS, Blaser MJ, London E Biochimica et biophysica acta. Biomembranes 31449801 Biochim Biophys Acta Biomembr 2019 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/31449801
Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile. Chen LA, Hourigan SK, Grigoryan Z, Gao Z, Clemente JC, Rideout JR, Chirumamilla S, Rabidazeh S, Saeed S, Elson CO, Oliva-Hemker M, Blaser MJ, Sears CL Journal of pediatric gastroenterology and nutrition 30540709 J Pediatr Gastroenterol Nutr 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30540709
Celecoxib does not alter intestinal microbiome in a longitudinal diet-controlled study. Bokulich NA, Battaglia T, Aleman JO, Walker JM, Blaser MJ, Holt PR Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 26806255 Clin Microbiol Infect 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26806255
Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania. Smits SA, Leach J, Sonnenburg ED, Gonzalez CG, Lichtman JS, Reid G, Knight R, Manjurano A, Changalucha J, Elias JE, Dominguez-Bello MG, Sonnenburg JL Science (New York, N.Y.) 28839072 Science 2017 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/28839072
Development of the Human Mycobiome over the First Month of Life and across Body Sites. Ward TL, Dominguez-Bello MG, Heisel T, Al-Ghalith G, Knights D, Gale CA mSystems 29546248 mSystems 2018 May-Jun https://www.ncbi.nlm.nih.gov/pubmed/29546248
Evidence for Environmental-Human Microbiota Transfer at a Manufacturing Facility with Novel Work-related Respiratory Disease. Wu BG, Kapoor B, Cummings KJ, Stanton ML, Nett RJ, Kreiss K, Abraham JL, Colby TV, Franko AD, Green FHY, Sanyal S, Clemente JC, Gao Z, Coffre M, Meyn P, Heguy A, Li Y, Sulaiman I, Borbet TC, Koralov SB, Tallaksen RJ, Wendland D, Bachelder VD, Boylstein RJ, Park JH, Cox-Ganser JM, Virji MA, Crawford JA, Edwards NT, Veillette M, Duchaine C, Warren K, Lundeen S, Blaser MJ, Segal LN American journal of respiratory and critical care medicine 32673495 Am J Respir Crit Care Med 2020 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/32673495
Helicobacter pylori in children with asthmatic conditions at school age, and their mothers. den Hollander WJ, Sonnenschein-van der Voort AM, Holster IL, de Jongste JC, Jaddoe VW, Hofman A, Perez-Perez GI, Moll HA, Blaser MJ, Duijts L, Kuipers EJ Alimentary pharmacology & therapeutics 26932510 Aliment Pharmacol Ther 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26932510
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, Kim SG, Li H, Gao Z, Mahana D, Zárate Rodriguez JG, Rogers AB, Robine N, Loke P, Blaser MJ Cell 25126780 Cell 2014 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/25126780
Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum. Shin H, Martinez KA 2nd, Henderson N, Jay M, Schweizer W, Bogaert D, Park G, Bokulich NA, Blaser MJ, Dominguez-Bello MG NPJ biofilms and microbiomes 37311781 NPJ Biofilms Microbiomes 2023 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/37311781
The Jeremiah Metzger Lecture: Global warming redux: the disappearing microbiota and epidemic obesity. Blaser MJ Transactions of the American Clinical and Climatological Association 23303990 Trans Am Clin Climatol Assoc 2012 https://www.ncbi.nlm.nih.gov/pubmed/23303990
The human microbiome: at the interface of health and disease. Cho I, Blaser MJ Nature reviews. Genetics 22411464 Nat Rev Genet 2012 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/22411464
Microbiome and malignancy. Plottel CS, Blaser MJ Cell host & microbe 22018233 Cell Host Microbe 2011 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/22018233
Pathways in microbe-induced obesity. Cox LM, Blaser MJ Cell metabolism 23747247 Cell Metab 2013 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/23747247
A brave new world: the lung microbiota in an era of change. Segal LN, Blaser MJ Annals of the American Thoracic Society 24437400 Ann Am Thorac Soc 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24437400
Helicobacter pylori and esophageal disease: wake-up call? Blaser MJ Gastroenterology 21029801 Gastroenterology 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/21029801
Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R Gastroenterology 21530737 Gastroenterology 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21530737
The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. Francois F, Roper J, Joseph N, Pei Z, Chhada A, Shak JR, de Perez AZ, Perez-Perez GI, Blaser MJ BMC gastroenterology 21489301 BMC Gastroenterol 2011 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/21489301
Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I, Chung J, Sohn J, Barber CM, Goldfarb DS, Raju K, Abubucker S, Zhou Y, Ruiz VE, Li H, Mitreva M, Alekseyenko AV, Weinstock GM, Sodergren E, Blaser MJ Nature communications 26123276 Nat Commun 2015 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/26123276
Risks of Antibiotic Exposures Early in Life on the Developing Microbiome. Schulfer A, Blaser MJ PLoS pathogens 26135581 PLoS Pathog 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26135581
Antibiotics in early life and obesity. Cox LM, Blaser MJ Nature reviews. Endocrinology 25488483 Nat Rev Endocrinol 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25488483
Sparse and compositionally robust inference of microbial ecological networks. Kurtz ZD, Müller CL, Miraldi ER, Littman DR, Blaser MJ, Bonneau RA PLoS computational biology 25950956 PLoS Comput Biol 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25950956
Antibiotic use and its consequences for the normal microbiome. Blaser MJ Science (New York, N.Y.) 27126037 Science 2016 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/27126037
The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer. Kwa M, Plottel CS, Blaser MJ, Adams S Journal of the National Cancer Institute 27107051 J Natl Cancer Inst 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27107051
Predominance of Lactobacillus spp. Among Patients Who Do Not Acquire Multidrug-Resistant Organisms. Araos R, Tai AK, Snyder GM, Blaser MJ, D'Agata EMC Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 27358350 Clin Infect Dis 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27358350
Loss of HDAC6 alters gut microbiota and worsens obesity. Lieber AD, Beier UH, Xiao H, Wilkins BJ, Jiao J, Li XS, Schugar RC, Strauch CM, Wang Z, Brown JM, Hazen SL, Bokulich NA, Ruggles KV, Akimova T, Hancock WW, Blaser MJ FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30102568 FASEB J 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30102568
Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer. Dominguez-Bello MG, De Jesus-Laboy KM, Shen N, Cox LM, Amir A, Gonzalez A, Bokulich NA, Song SJ, Hoashi M, Rivera-Vinas JI, Mendez K, Knight R, Clemente JC Nature medicine 26828196 Nat Med 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26828196
A powerful microbiome-based association test and a microbial taxa discovery framework for comprehensive association mapping. Koh H, Blaser MJ, Li H Microbiome 28438217 Microbiome 2017 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/28438217
Severe lung disease characterized by lymphocytic bronchiolitis, alveolar ductitis, and emphysema (BADE) in industrial machine-manufacturing workers. Cummings KJ, Stanton ML, Nett RJ, Segal LN, Kreiss K, Abraham JL, Colby TV, Franko AD, Green FHY, Sanyal S, Tallaksen RJ, Wendland D, Bachelder VD, Boylstein RJ, Park JH, Cox-Ganser JM, Virji MA, Crawford JA, Green BJ, LeBouf RF, Blaser MJ, Weissman DN American journal of industrial medicine 31461179 Am J Ind Med 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31461179
Longitudinal changes of microbiome composition and microbial metabolomics after surgical weight loss in individuals with obesity. Shen N, Caixàs A, Ahlers M, Patel K, Gao Z, Dutia R, Blaser MJ, Clemente JC, Laferrère B Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 31296445 Surg Obes Relat Dis 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31296445
Antibiotics, birth mode, and diet shape microbiome maturation during early life. Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, Li H, D Lieber A, Wu F, Perez-Perez GI, Chen Y, Schweizer W, Zheng X, Contreras M, Dominguez-Bello MG, Blaser MJ Science translational medicine 27306664 Sci Transl Med 2016 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/27306664
A multivariate distance-based analytic framework for microbial interdependence association test in longitudinal study. Zhang Y, Han SW, Cox LM, Li H Genetic epidemiology 28872698 Genet Epidemiol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28872698
Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD Nature microbiology 27572644 Nat Microbiol 2016 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/27572644
Helminth infection promotes colonization resistance via type 2 immunity. Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K Science (New York, N.Y.) 27080105 Science 2016 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/27080105
Helicobacter pylori and the birth cohort effect: evidence for stabilized colonization rates in childhood. den Hoed CM, Vila AJ, Holster IL, Perez-Perez GI, Blaser MJ, de Jongste JC, Kuipers EJ Helicobacter 21923687 Helicobacter 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21923687
Infant antibiotic exposures and early-life body mass. Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ International journal of obesity (2005) 22907693 Int J Obes (Lond) 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/22907693
Candida krusei colonization in patients with gastrointestinal diseases. Huong DT, Zhao Y, Nguyet NT, Loan TT, Binh NT, Thinh NV, Hanh NT, Perez-Perez GI, Perlin DS Medical mycology 23815437 Med Mycol 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/23815437
Harnessing the Early-Life Microbiota to Protect Children with Cystic Fibrosis. Segal LN, Blaser MJ The Journal of pediatrics 25934071 J Pediatr 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25934071
Toward a Predictive Understanding of Earth's Microbiomes to Address 21st Century Challenges. Blaser MJ, Cardon ZG, Cho MK, Dangl JL, Donohue TJ, Green JL, Knight R, Maxon ME, Northen TR, Pollard KS, Brodie EL mBio 27178263 mBio 2016 May 13 https://www.ncbi.nlm.nih.gov/pubmed/27178263
Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet. Mahana D, Trent CM, Kurtz ZD, Bokulich NA, Battaglia T, Chung J, Müller CL, Li H, Bonneau RA, Blaser MJ Genome medicine 27124954 Genome Med 2016 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/27124954
Role of childhood infection in the sequelae of H. pylori disease. Harris PR, Smythies LE, Smith PD, Perez-Perez GI Gut microbes 24275060 Gut Microbes 2013 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/24275060
Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Segal LN, Alekseyenko AV, Clemente JC, Kulkarni R, Wu B, Gao Z, Chen H, Berger KI, Goldring RM, Rom WN, Blaser MJ, Weiden MD Microbiome 24450871 Microbiome 2013 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/24450871
Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi-ethnic European city. den Hollander WJ, Holster IL, den Hoed CM, van Deurzen F, van Vuuren AJ, Jaddoe VW, Hofman A, Perez Perez GI, Blaser MJ, Moll HA, Kuipers EJ Journal of gastroenterology and hepatology 23808840 J Gastroenterol Hepatol 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/23808840
The Human Microbiome before Birth. Blaser MJ, Dominguez-Bello MG Cell host & microbe 27832586 Cell Host Microbe 2016 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/27832586
Helicobacter pylori colonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth. den Hollander WJ, Schalekamp-Timmermans S, Holster IL, Jaddoe VW, Hofman A, Moll HA, Perez-Perez GI, Blaser MJ, Steegers EA, Kuipers EJ Helicobacter 27786400 Helicobacter 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/27786400
The theory of disappearing microbiota and the epidemics of chronic diseases. Blaser MJ Nature reviews. Immunology 28749457 Nat Rev Immunol 2017 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/28749457
Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Schulfer AF, Battaglia T, Alvarez Y, Bijnens L, Ruiz VE, Ho M, Robinson S, Ward T, Cox LM, Rogers AB, Knights D, Sartor RB, Blaser MJ Nature microbiology 29180726 Nat Microbiol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29180726
A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. Ruiz VE, Battaglia T, Kurtz ZD, Bijnens L, Ou A, Engstrand I, Zheng X, Iizumi T, Mullins BJ, Müller CL, Cadwell K, Bonneau R, Perez-Perez GI, Blaser MJ Nature communications 28894149 Nat Commun 2017 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/28894149
Joint modeling of zero-inflated longitudinal proportions and time-to-event data with application to a gut microbiome study. Hu J, Wang C, Blaser MJ, Li H Biometrics 34213763 Biometrics 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/34213763
Links between environment, diet, and the hunter-gatherer microbiome. Fragiadakis GK, Smits SA, Sonnenburg ED, Van Treuren W, Reid G, Knight R, Manjurano A, Changalucha J, Dominguez-Bello MG, Leach J, Sonnenburg JL Gut microbes 30118385 Gut Microbes 2019 https://www.ncbi.nlm.nih.gov/pubmed/30118385
The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes. Schulfer AF, Schluter J, Zhang Y, Brown Q, Pathmasiri W, McRitchie S, Sumner S, Li H, Xavier JB, Blaser MJ The ISME journal 30651608 ISME J 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30651608
Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota. den Hartigh LJ, Gao Z, Goodspeed L, Wang S, Das AK, Burant CF, Chait A, Blaser MJ The Journal of nutrition 29659960 J Nutr 2018 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/29659960
Risk of Clostridium difficile Infection in Patients With Celiac Disease: A Population-Based Study. Lebwohl B, Nobel YR, Green PHR, Blaser MJ, Ludvigsson JF The American journal of gastroenterology 29087398 Am J Gastroenterol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29087398
Detecting a bacterial protein to understand cancer risk. Blaser MJ Clinical chemistry 21586641 Clin Chem 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21586641
The nonfermentable dietary fiber hydroxypropyl methylcellulose modulates intestinal microbiota. Cox LM, Cho I, Young SA, Anderson WH, Waters BJ, Hung SC, Gao Z, Mahana D, Bihan M, Alekseyenko AV, Methé BA, Blaser MJ FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23154883 FASEB J 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23154883
Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels. Chen Y, Blaser MJ The Journal of infectious diseases 22427676 J Infect Dis 2012 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/22427676
Host demise as a beneficial function of indigenous microbiota in human hosts. Blaser MJ, Webb GF mBio 25516618 mBio 2014 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/25516618
Oxalobacter formigenes-associated host features and microbial community structures examined using the American Gut Project. Liu M, Koh H, Kurtz ZD, Battaglia T, PeBenito A, Li H, Nazzal L, Blaser MJ Microbiome 28841836 Microbiome 2017 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/28841836
The Presence of Oxalobacter formigenes in the Microbiome of Healthy Young Adults. Barnett C, Nazzal L, Goldfarb DS, Blaser MJ The Journal of urology 26292041 J Urol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26292041
Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. Segal LN, Clemente JC, Wu BG, Wikoff WR, Gao Z, Li Y, Ko JP, Rom WN, Blaser MJ, Weiden MD Thorax 27486204 Thorax 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27486204
Microbially Produced Acetate: A "Missing Link" in Understanding Obesity? Trent CM, Blaser MJ Cell metabolism 27411005 Cell Metab 2016 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/27411005
Maturation of the gut microbiome and risk of asthma in childhood. Stokholm J, Blaser MJ, Thorsen J, Rasmussen MA, Waage J, Vinding RK, Schoos AM, Kunøe A, Fink NR, Chawes BL, Bønnelykke K, Brejnrod AD, Mortensen MS, Al-Soud WA, Sørensen SJ, Bisgaard H Nature communications 29321519 Nat Commun 2018 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/29321519
A highly adaptive microbiome-based association test for survival traits. Koh H, Livanos AE, Blaser MJ, Li H BMC genomics 29558893 BMC Genomics 2018 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/29558893
Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women. Alemán JO, Bokulich NA, Swann JR, Walker JM, De Rosa JC, Battaglia T, Costabile A, Pechlivanis A, Liang Y, Breslow JL, Blaser MJ, Holt PR Journal of translational medicine 30176893 J Transl Med 2018 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/30176893
Asthma: Undoing millions of years of coevolution in early life? Dominguez-Bello MG, Blaser MJ Science translational medicine 26424565 Sci Transl Med 2015 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/26424565
Helminth colonization is associated with increased diversity of the gut microbiota. Lee SC, Tang MS, Lim YA, Choy SH, Kurtz ZD, Cox LM, Gundra UM, Cho I, Bonneau R, Blaser MJ, Chua KH, Loke P PLoS neglected tropical diseases 24851867 PLoS Negl Trop Dis 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24851867
Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city. den Hollander WJ, Holster IL, van Gilst B, van Vuuren AJ, Jaddoe VW, Hofman A, Perez-Perez GI, Kuipers EJ, Moll HA, Blaser MJ Gut 25192563 Gut 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/25192563
Description of two novel members of the family Erysipelotrichaceae: Ileibacterium valens gen. nov., sp. nov. and Dubosiella newyorkensis, gen. nov., sp. nov., from the murine intestine, and emendation to the description of Faecalibaculum rodentium. Cox LM, Sohn J, Tyrrell KL, Citron DM, Lawson PA, Patel NB, Iizumi T, Perez-Perez GI, Goldstein EJC, Blaser MJ International journal of systematic and evolutionary microbiology 28100298 Int J Syst Evol Microbiol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28100298
Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course. Ventura RE, Iizumi T, Battaglia T, Liu M, Perez-Perez GI, Herbert J, Blaser MJ Scientific reports 31705027 Sci Rep 2019 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/31705027
Work-related adverse respiratory health outcomes at a machine manufacturing facility with a cluster of bronchiolitis, alveolar ductitis and emphysema (BADE). Cummings KJ, Stanton ML, Kreiss K, Boylstein RJ, Park JH, Cox-Ganser JM, Virji MA, Edwards NT, Segal LN, Blaser MJ, Weissman DN, Nett RJ Occupational and environmental medicine 32132182 Occup Environ Med 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32132182
Effect of antibiotic treatment on Oxalobacter formigenes colonization of the gut microbiome and urinary oxalate excretion. Nazzal L, Francois F, Henderson N, Liu M, Li H, Koh H, Wang C, Gao Z, Perez GP, Asplin JR, Goldfarb DS, Blaser MJ Scientific reports 34385560 Sci Rep 2021 Aug 12 https://www.ncbi.nlm.nih.gov/pubmed/34385560
Pleomorphic ensembles: formation of large clusters composed of weakly interacting multivalent molecules. Falkenberg CV, Blinov ML, Loew LM Biophysical journal 24314076 Biophys J 2013 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/24314076
Interconnected network motifs control podocyte morphology and kidney function. Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R Science signaling 24497609 Sci Signal 2014 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/24497609
Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T The Journal of neuroscience : the official journal of the Society for Neuroscience 27559174 J Neurosci 2016 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/27559174
A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction. Hu M, Azeloglu EU, Ron A, Tran-Ba KH, Calizo RC, Tavassoly I, Bhattacharya S, Jayaraman G, Chen Y, Rabinovich V, Iyengar R, Hone JC, He JC, Kaufman LJ Scientific reports 28262745 Sci Rep 2017 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/28262745
Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking. Song RS, Tolentino R, Sobie EA, Neves-Zaph SR The Journal of biological chemistry 27605670 J Biol Chem 2016 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/27605670
Computational analysis of Rho GTPase cycling. Falkenberg CV, Loew LM PLoS computational biology 23326220 PLoS Comput Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23326220
Modeling of spatially-restricted intracellular signaling. Neves SR Wiley interdisciplinary reviews. Systems biology and medicine 21766466 Wiley Interdiscip Rev Syst Biol Med 2012 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/21766466
Systems biology of kidney diseases. He JC, Chuang PY, Ma'ayan A, Iyengar R Kidney international 21881558 Kidney Int 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/21881558
ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. Song RS, Massenburg B, Wenderski W, Jayaraman V, Thompson L, Neves SR Proceedings of the National Academy of Sciences of the United States of America 23986500 Proc Natl Acad Sci U S A 2013 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/23986500
Cell shape information is transduced through tension-independent mechanisms. Ron A, Azeloglu EU, Calizo RC, Hu M, Bhattacharya S, Chen Y, Jayaraman G, Lee S, Neves-Zaph SR, Li H, Gordon RE, He JC, Hone JC, Iyengar R Nature communications 29247198 Nat Commun 2017 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/29247198
Obtaining and estimating kinetic parameters from the literature. Neves SR Science signaling 21934111 Sci Signal 2011 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/21934111
Modeling of spatial intracellular signaling events in neurons. Wenderski WC, Neves SR Methods in enzymology 22289450 Methods Enzymol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22289450
G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. Hwangpo TA, Jordan JD, Premsrirut PK, Jayamaran G, Licht JD, Iyengar R, Neves SR The Journal of biological chemistry 22383529 J Biol Chem 2012 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/22383529
Developing models in virtual cell. Neves SR Science signaling 21954293 Sci Signal 2011 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/21954293
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Skarulis MC, Ju C, Aouadi M, Czech MP, Kunos G Nature medicine 23955712 Nat Med 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23955712
CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Guo CA, Kogan S, Amano SU, Wang M, Dagdeviren S, Friedline RH, Aouadi M, Kim JK, Czech MP American journal of physiology. Endocrinology and metabolism 23482447 Am J Physiol Endocrinol Metab 2013 May 1 https://www.ncbi.nlm.nih.gov/pubmed/23482447
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M Cell metabolism 24374218 Cell Metab 2014 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/24374218
IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, Kim JK, Czech MP PloS one 25216251 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25216251
Insulin signalling mechanisms for triacylglycerol storage. Czech MP, Tencerova M, Pedersen DJ, Aouadi M Diabetologia 23443243 Diabetologia 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23443243
Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Tesz GJ, Aouadi M, Prot M, Nicoloro SM, Boutet E, Amano SU, Goller A, Wang M, Guo CA, Salomon WE, Virbasius JV, Baum RA, O'Connor MJ Jr, Soto E, Ostroff GR, Czech MP The Biochemical journal 21418037 Biochem J 2011 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/21418037
Activated Kupffer cells inhibit insulin sensitivity in obese mice. Tencerova M, Aouadi M, Vangala P, Nicoloro SM, Yawe JC, Cohen JL, Shen Y, Garcia-Menendez L, Pedersen DJ, Gallagher-Dorval K, Perugini RA, Gupta OT, Czech MP FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25805830 FASEB J 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25805830
Insulin action and resistance in obesity and type 2 diabetes. Czech MP Nature medicine 28697184 Nat Med 2017 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/28697184
RNAi-based therapeutic strategies for metabolic disease. Czech MP, Aouadi M, Tesz GJ Nature reviews. Endocrinology 21502982 Nat Rev Endocrinol 2011 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/21502982
Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance. Aouadi M, Vangala P, Yawe JC, Tencerova M, Nicoloro SM, Cohen JL, Shen Y, Czech MP American journal of physiology. Endocrinology and metabolism 24986598 Am J Physiol Endocrinol Metab 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24986598
A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles. De Jesus M, Ostroff GR, Levitz SM, Bartling TR, Mantis NJ PloS one 24632738 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24632738
Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA. Cohen JL, Shen Y, Aouadi M, Vangala P, Tencerova M, Amano SU, Nicoloro SM, Yawe JC, Czech MP Molecular pharmaceutics 26815386 Mol Pharm 2016 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/26815386
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP Proceedings of the National Academy of Sciences of the United States of America 23630254 Proc Natl Acad Sci U S A 2013 May 14 https://www.ncbi.nlm.nih.gov/pubmed/23630254
Regulation of self-renewal and differentiation by the intestinal stem cell niche. Yeung TM, Chia LA, Kosinski CM, Kuo CJ Cellular and molecular life sciences : CMLS 21509540 Cell Mol Life Sci 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21509540
Avidity-controlled hydrogels for injectable co-delivery of induced pluripotent stem cell-derived endothelial cells and growth factors. Mulyasasmita W, Cai L, Dewi RE, Jha A, Ullmann SD, Luong RH, Huang NF, Heilshorn SC Journal of controlled release : official journal of the Controlled Release Society 24848744 J Control Release 2014 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/24848744
Spontaneous cardiomyocyte differentiation of mouse embryoid bodies regulated by hydrogel crosslink density. Chung C, Pruitt BL, Heilshorn SC Biomaterials science 24748962 Biomater Sci 2013 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/24748962
Molecular-level engineering of protein physical hydrogels for predictive sol-gel phase behavior. Mulyasasmita W, Lee JS, Heilshorn SC Biomacromolecules 21861461 Biomacromolecules 2011 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/21861461
Protein-engineered scaffolds for in vitro 3D culture of primary adult intestinal organoids. DiMarco RL, Dewi RE, Bernal G, Kuo C, Heilshorn SC Biomaterials science 26371971 Biomater Sci 2015 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/26371971
Adaptable hydrogel networks with reversible linkages for tissue engineering. Wang H, Heilshorn SC Advanced materials (Deerfield Beach, Fla.) 25989348 Adv Mater 2015 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/25989348
Hybrid elastin-like polypeptide-polyethylene glycol (ELP-PEG) hydrogels with improved transparency and independent control of matrix mechanics and cell ligand density. Wang H, Cai L, Paul A, Enejder A, Heilshorn SC Biomacromolecules 25111283 Biomacromolecules 2014 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/25111283
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, Root DE, Mesirov JP, Beroukhim R, Kuo CJ, Goessling W, Hahn WC Cell 23245941 Cell 2012 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/23245941
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, Kuo CJ Nature medicine 19398967 Nat Med 2009 Jun https://www.ncbi.nlm.nih.gov/pubmed/19398967
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ Nature medicine 24859528 Nat Med 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24859528
Small-molecule axon-polarization studies enabled by a shear-free microfluidic gradient generator. Xu H, Ferreira MM, Heilshorn SC Lab on a chip 24781157 Lab Chip 2014 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/24781157
Matrix RGD ligand density and L1CAM-mediated Schwann cell interactions synergistically enhance neurite outgrowth. Romano NH, Madl CM, Heilshorn SC Acta biomaterialia 25308870 Acta Biomater 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25308870
Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities. Romano NH, Lampe KJ, Xu H, Ferreira MM, Heilshorn SC Small (Weinheim an der Bergstrasse, Germany) 25315156 Small 2015 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/25315156
Organoid modeling for cancer precision medicine. Cantrell MA, Kuo CJ Genome medicine 25825593 Genome Med 2015 https://www.ncbi.nlm.nih.gov/pubmed/25825593
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Yan KS, Chia LA, Li X, Ootani A, Su J, Lee JY, Su N, Luo Y, Heilshorn SC, Amieva MR, Sangiorgi E, Capecchi MR, Kuo CJ Proceedings of the National Academy of Sciences of the United States of America 22190486 Proc Natl Acad Sci U S A 2012 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/22190486
Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling. Shkreli M, Sarin KY, Pech MF, Papeta N, Chang W, Brockman SA, Cheung P, Lee E, Kuhnert F, Olson JL, Kuo CJ, Gharavi AG, D'Agati VD, Artandi SE Nature medicine 22138751 Nat Med 2011 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/22138751
Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Aguado BA, Mulyasasmita W, Su J, Lampe KJ, Heilshorn SC Tissue engineering. Part A 22011213 Tissue Eng Part A 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22011213
Multifunctional materials through modular protein engineering. DiMarco RL, Heilshorn SC Advanced materials (Deerfield Beach, Fla.) 22730248 Adv Mater 2012 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/22730248
Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding. Madl CM, Heilshorn SC Neural regeneration research 26170800 Neural Regen Res 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/26170800
Injectable Hydrogels with In Situ Double Network Formation Enhance Retention of Transplanted Stem Cells. Cai L, Dewi RE, Heilshorn SC Advanced functional materials 26273242 Adv Funct Mater 2015 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/26273242
Organoids as Models for Neoplastic Transformation. Neal JT, Kuo CJ Annual review of pathology 26907527 Annu Rev Pathol 2016 May 23 https://www.ncbi.nlm.nih.gov/pubmed/26907527
Dual-stage growth factor release within 3D protein-engineered hydrogel niches promotes adipogenesis. Greenwood-Goodwin M, Teasley ES, Heilshorn SC Biomaterials science 25309741 Biomater Sci 2014 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/25309741
Designing ECM-mimetic materials using protein engineering. Cai L, Heilshorn SC Acta biomaterialia 24365704 Acta Biomater 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24365704
One-pot Synthesis of Elastin-like Polypeptide Hydrogels with Grafted VEGF-Mimetic Peptides. Cai L, Dinh CB, Heilshorn SC Biomaterials science 24729868 Biomater Sci 2014 May 1 https://www.ncbi.nlm.nih.gov/pubmed/24729868
Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R Science (New York, N.Y.) 24311688 Science 2013 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/24311688
Engineering of three-dimensional microenvironments to promote contractile behavior in primary intestinal organoids. DiMarco RL, Su J, Yan KS, Dewi R, Kuo CJ, Heilshorn SC Integrative biology : quantitative biosciences from nano to macro 24343706 Integr Biol (Camb) 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24343706
Partial proteasome inhibitors induce hair follicle growth by stabilizing β-catenin. Yucel G, Van Arnam J, Means PC, Huntzicker E, Altindag B, Lara MF, Yuan J, Kuo C, Oro AE Stem cells (Dayton, Ohio) 23963711 Stem Cells 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23963711
Technology Roadmap for Flexible Sensors. Luo Y, Abidian MR, Ahn JH, Akinwande D, Andrews AM, Antonietti M, Bao Z, Berggren M, Berkey CA, Bettinger CJ, Chen J, Chen P, Cheng W, Cheng X, Choi SJ, Chortos A, Dagdeviren C, Dauskardt RH, Di CA, Dickey MD, Duan X, Facchetti A, Fan Z, Fang Y, Feng J, Feng X, Gao H, Gao W, Gong X, Guo CF, Guo X, Hartel MC, He Z, Ho JS, Hu Y, Huang Q, Huang Y, Huo F, Hussain MM, Javey A, Jeong U, Jiang C, Jiang X, Kang J, Karnaushenko D, Khademhosseini A, Kim DH, Kim ID, Kireev D, Kong L, Lee C, Lee NE, Lee PS, Lee TW, Li F, Li J, Liang C, Lim CT, Lin Y, Lipomi DJ, Liu J, Liu K, Liu N, Liu R, Liu Y, Liu Y, Liu Z, Liu Z, Loh XJ, Lu N, Lv Z, Magdassi S, Malliaras GG, Matsuhisa N, Nathan A, Niu S, Pan J, Pang C, Pei Q, Peng H, Qi D, Ren H, Rogers JA, Rowe A, Schmidt OG, Sekitani T, Seo DG, Shen G, Sheng X, Shi Q, Someya T, Song Y, Stavrinidou E, Su M, Sun X, Takei K, Tao XM, Tee BCK, Thean AV, Trung TQ, Wan C, Wang H, Wang J, Wang M, Wang S, Wang T, Wang ZL, Weiss PS, Wen H, Xu S, Xu T, Yan H, Yan X, Yang H, Yang L, Yang S, Yin L, Yu C, Yu G, Yu J, Yu SH, Yu X, Zamburg E, Zhang H, Zhang X, Zhang X, Zhang X, Zhang Y, Zhang Y, Zhao S, Zhao X, Zheng Y, Zheng YQ, Zheng Z, Zhou T, Zhu B, Zhu M, Zhu R, Zhu Y, Zhu Y, Zou G, Chen X ACS nano 36892156 ACS Nano 2023 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/36892156
Implantable aptamer-field-effect transistor neuroprobes for in vivo neurotransmitter monitoring. Zhao C, Cheung KM, Huang IW, Yang H, Nakatsuka N, Liu W, Cao Y, Man T, Weiss PS, Monbouquette HG, Andrews AM Science advances 34818033 Sci Adv 2021 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/34818033
Chemical Lift-Off Lithography of Metal and Semiconductor Surfaces. Cheung KM, Stemer DM, Zhao C, Young TD, Belling JN, Andrews AM, Weiss PS ACS materials letters 32405626 ACS Mater Lett 2020 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/32405626
Differential Charging in Photoemission from Mercurated DNA Monolayers on Ferromagnetic Films. Stemer DM, Abendroth JM, Cheung KM, Ye M, El Hadri MS, Fullerton EE, Weiss PS Nano letters 31960675 Nano Lett 2020 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/31960675
Hydrogel Microfilaments toward Intradermal Health Monitoring. Tejavibulya N, Colburn DAM, Marcogliese FA, Yang KA, Guo V, Chowdhury S, Stojanovic MN, Sia SK iScience 31698247 iScience 2019 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/31698247
Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications. Nakatsuka N, Hasani-Sadrabadi MM, Cheung KM, Young TD, Bahlakeh G, Moshaverinia A, Weiss PS, Andrews AM ACS nano 29664607 ACS Nano 2018 May 22 https://www.ncbi.nlm.nih.gov/pubmed/29664607
Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. Dunlap LE, Andrews AM, Olson DE ACS chemical neuroscience 30001118 ACS Chem Neurosci 2018 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/30001118
Maximizing Electrochemical Information: A Perspective on Background-Inclusive Fast Voltammetry. Movassaghi CS, Alcañiz Fillol M, Kishida KT, McCarty G, Sombers LA, Wassum KM, Andrews AM Analytical chemistry 38597398 Anal Chem 2024 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/38597398
Large-Area, Ultrathin Metal-Oxide Semiconductor Nanoribbon Arrays Fabricated by Chemical Lift-Off Lithography. Zhao C, Xu X, Bae SH, Yang Q, Liu W, Belling JN, Cheung KM, Rim YS, Yang Y, Andrews AM, Weiss PS Nano letters 30060654 Nano Lett 2018 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/30060654
Lipid-Bicelle-Coated Microfluidics for Intracellular Delivery with Reduced Fouling. Belling JN, Heidenreich LK, Park JH, Kawakami LM, Takahashi J, Frost IM, Gong Y, Young TD, Jackman JA, Jonas SJ, Cho NJ, Weiss PS ACS applied materials & interfaces 32940030 ACS Appl Mater Interfaces 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/32940030
Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression. Movassaghi CS, Perrotta KA, Yang H, Iyer R, Cheng X, Dagher M, Fillol MA, Andrews AM Analytical and bioanalytical chemistry 34686897 Anal Bioanal Chem 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34686897
Improved genetically encoded near-infrared fluorescent calcium ion indicators for in vivo imaging. Qian Y, Cosio DMO, Piatkevich KD, Aufmkolk S, Su WC, Celiker OT, Schohl A, Murdock MH, Aggarwal A, Chang YF, Wiseman PW, Ruthazer ES, Boyden ES, Campbell RE PLoS biology 33232322 PLoS Biol 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33232322
Synthesis of PEG-grafted boron doped Si nanocrystals. Greenhagen JR, Andaraarachchi HP, Li Z, Kortshagen UR The Journal of chemical physics 31822090 J Chem Phys 2019 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/31822090
Structures and topological defects in pressure-driven lyotropic chromonic liquid crystals. Zhang Q, Zhang R, Ge B, Yaqoob Z, So PTC, Bischofberger I Proceedings of the National Academy of Sciences of the United States of America 34446562 Proc Natl Acad Sci U S A 2021 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/34446562
Aerosol-Phase Synthesis and Processing of Luminescent Silicon Nanocrystals. Li Z, Kortshagen UR Chemistry of materials : a publication of the American Chemical Society 34163100 Chem Mater 2019 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/34163100
Water-Soluble Luminescent Silicon Nanocrystals by Plasma-Induced Acrylic Acid Grafting and PEGylation. Li Z, Mahajan A, Andaraarachchi HP, Lee Y, Kortshagen UR ACS applied bio materials 35014827 ACS Appl Bio Mater 2022 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/35014827
Mapping nanoscale topographic features in thick tissues with speckle diffraction tomography. Kang S, Zhou R, Brelen M, Mak HK, Lin Y, So PTC, Yaqoob Z Light, science & applications 37607903 Light Sci Appl 2023 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/37607903
Optical diffraction tomography for assessing single cell models in angular light scattering. Dunn KJ, Matlock A, Funkenbusch G, Yaqoob Z, So PTC, Berger AJ Biomedical optics express 38404316 Biomed Opt Express 2024 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/38404316
Fast light-field 3D microscopy with out-of-distribution detection and adaptation through conditional normalizing flows. Page Vizcaíno J, Symvoulidis P, Wang Z, Jelten J, Favaro P, Boyden ES, Lasser T Biomedical optics express 38404325 Biomed Opt Express 2024 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/38404325
Single-Shot Quantitative Polarization Imaging of Complex Birefringent Structure Dynamics. Ge B, Zhang Q, Zhang R, Lin JT, Tseng PH, Chang CW, Dong CY, Zhou R, Yaqoob Z, Bischofberger I, So PTC ACS photonics 37292495 ACS Photonics 2021 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/37292495
A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy. Gao R, Yu CJ, Gao L, Piatkevich KD, Neve RL, Munro JB, Upadhyayula S, Boyden ES Nature nanotechnology 33782587 Nat Nanotechnol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33782587
Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E Science (New York, N.Y.) 30655415 Science 2019 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/30655415
Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Murdock MH, Yang CY, Sun N, Pao PC, Blanco-Duque C, Kahn MC, Kim T, Lavoie NS, Victor MB, Islam MR, Galiana F, Leary N, Wang S, Bubnys A, Ma E, Akay LA, Sneve M, Qian Y, Lai C, McCarthy MM, Kopell N, Kellis M, Piatkevich KD, Boyden ES, Tsai LH Nature 38418876 Nature 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38418876
Distance-dependent resonance energy transfer in alkyl-terminated Si nanocrystal solids. Li Z, Robinson ZL, Elvati P, Violi A, Kortshagen UR The Journal of chemical physics 35364875 J Chem Phys 2022 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/35364875
Recording of cellular physiological histories along optically readable self-assembling protein chains. Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES Nature biotechnology 36593405 Nat Biotechnol 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36593405
In vivo visualization of butterfly scale cell morphogenesis in Vanessa cardui. McDougal AD, Kang S, Yaqoob Z, So PTC, Kolle M Proceedings of the National Academy of Sciences of the United States of America 34845021 Proc Natl Acad Sci U S A 2021 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/34845021
In situ genome sequencing resolves DNA sequence and structure in intact biological samples. Payne AC, Chiang ZD, Reginato PL, Mangiameli SM, Murray EM, Yao CC, Markoulaki S, Earl AS, Labade AS, Jaenisch R, Church GM, Boyden ES, Buenrostro JD, Chen F Science (New York, N.Y.) 33384301 Science 2021 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/33384301
Fast light-field 3D microscopy with out-of-distribution detection and adaptation through Conditional Normalizing Flows. Vizcaíno JP, Symvoulidis P, Wang Z, Jelten J, Favaro P, Boyden ES, Lasser T ArXiv 37396615 ArXiv 2023 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/37396615
Dynamics of microcompartment formation at the mitosis-to-G1 transition. Goel VY, Aboreden NG, Jusuf JM, Zhang H, Mori LP, Mirny LA, Blobel GA, Banigan EJ, Hansen AS Nature structural & molecular biology 41107486 Nat Struct Mol Biol 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41107486
Enhancer selectivity in space and time: from enhancer-promoter interactions to promoter activation. Yang JH, Hansen AS Nature reviews. Molecular cell biology 38413840 Nat Rev Mol Cell Biol 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38413840
Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription. Nagano M, Hansen AS Cell genomics 40081334 Cell Genom 2025 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/40081334
Genome structure mapping with high-resolution 3D genomics and deep learning. Hong CKY, Feng F, Ramanathan V, Liu J, Hansen AS bioRxiv : the preprint server for biology 40654659 bioRxiv 2025 May 7 https://www.ncbi.nlm.nih.gov/pubmed/40654659
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function. Narducci DN, Hansen AS Molecular cell 39708803 Mol Cell 2025 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/39708803
Molecular models of bidirectional promoter regulation. Nemsick S, Hansen AS Current opinion in structural biology 38905929 Curr Opin Struct Biol 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38905929
Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude. Mazzocca M, Narducci DN, Grosse-Holz S, Matthias J, Hansen AS bioRxiv : the preprint server for biology 40463058 bioRxiv 2025 May 14 https://www.ncbi.nlm.nih.gov/pubmed/40463058
Editorial overview: Emerging perspectives in genome architecture and gene regulation. Nollmann M, Hansen AS Current opinion in genetics & development 40359646 Curr Opin Genet Dev 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40359646
Dynamics of microcompartment formation at the mitosis-to-G1 transition. Goel VY, Aboreden NG, Jusuf JM, Zhang H, Mori LP, Mirny LA, Blobel GA, Banigan EJ, Hansen AS bioRxiv : the preprint server for biology 39345388 bioRxiv 2024 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/39345388
LDB1 establishes multi-enhancer networks to regulate gene expression. Aboreden NG, Lam JC, Goel VY, Wang S, Wang X, Midla SC, Quijano A, Keller CA, Giardine BM, Hardison RC, Zhang H, Hansen AS, Blobel GA bioRxiv : the preprint server for biology 39229045 bioRxiv 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39229045
Genome-wide absolute quantification of chromatin looping. Jusuf JM, Grosse-Holz S, Gabriele M, Mach P, Flyamer IM, Zechner C, Giorgetti L, Mirny LA, Hansen AS bioRxiv : the preprint server for biology 39935886 bioRxiv 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39935886
Macrocyclic Peptides Containing an Imidazopyridinium (IP(+)) Unit Display Enhanced Passive Cell Permeability. Li B, Parker J, Briggs S, Dong J, Burke JM, Kodadek T bioRxiv : the preprint server for biology 41279749 bioRxiv 2025 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/41279749
Assessing the Suitability of Deubiquitylases As Substrates For Targeted Protein Degradation. Tong J, Watkins JM, Burke JM, Kodadek T bioRxiv : the preprint server for biology 40661558 bioRxiv 2025 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/40661558
Catalytic Protein Inhibitors. Kodadek T Angewandte Chemie (International ed. in English) 38064411 Angew Chem Int Ed Engl 2024 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/38064411
A selective S-acyltransferase inhibitor suppresses tumor growth. Lee JY, Dilones S, Maujean T, Asad M, Mohd A, Auslander N, Brady DC, Burslem GM, Witze ES bioRxiv : the preprint server for biology 39091878 bioRxiv 2024 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/39091878
Juneteenth in STEMM and the barriers to equitable science. Mays A, Byars-Winston A, Hinton A Jr, Marshall AG, Kirabo A, August A, Marlin BJ, Riggs B, Tolbert B, Wanjalla C, Womack C, Evans CS, Barnes C, Starbird C, Williams C, Reynolds C, Taabazuing C, Cameron CE, Murray DD, Applewhite D, Morton DJ, Lee D, Williams DW, Lynch D, Brady D, Lynch E, Rutaganira FUN, Silva GM, Shuler H, Saboor IA, Davis J, Dzirasa K, Hammonds-Odie L, Reyes L, Sweetwyne MT, McReynolds MR, Johnson MDL, Smith NA, Pittman N, Ajijola OA, Smith Q, Robinson RAS, Lewis SC, Murray SA, Black S, Neal SE, Andrisse S, Townsend S, Damo SM, Griffith TN, Lambert WM, Clemons WM Jr Cell 37295396 Cell 2023 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/37295396
RASopathy mutations open new insights into the mechanism of BRAF activation. Dar AC, Brady DC Molecular cell 36400004 Mol Cell 2022 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/36400004
Patient-Derived Organoids as Therapy Screening Platforms in Cancer Patients. Khorsandi D, Yang JW, Foster S, Khosravi S, Hosseinzadeh Kouchehbaghi N, Zarei F, Lee YB, Runa F, Gangrade A, Voskanian L, Adnan D, Zhu Y, Wang Z, Jucaud V, Dokmeci MR, Shen X, Bishehsari F, Kelber JA, Khademhosseini A, de Barros NR Advanced healthcare materials 38359321 Adv Healthc Mater 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38359321
Reorganization of pancreas circadian transcriptome with aging. Sharma D, Wessel CR, Mahdavinia M, Preuss F, Bishehsari F Aging 37647013 Aging (Albany NY) 2023 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/37647013
Alcohol Drinking Without Meals Is Associated With Risk of Gastrointestinal Cancers, Including Early-Onset Cases. Shi M, Ahmedin NJ, Zong X, Yilmaz ӦH, Bishehsari F, Cao Y Gastroenterology 37977310 Gastroenterology 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37977310
Circadian transcriptome of pancreatic adenocarcinoma unravels chronotherapeutic targets. Sharma D, Adnan D, Abdel-Reheem MK, Anafi RC, Leary DD, Bishehsari F JCI insight 38716727 JCI Insight 2024 May 8 https://www.ncbi.nlm.nih.gov/pubmed/38716727
Early-onset Colon Cancer Shows a Distinct Intestinal Microbiome and a Host-Microbe Interaction. Adnan D, Trinh JQ, Sharma D, Alsayid M, Bishehsari F Cancer prevention research (Philadelphia, Pa.) 37967575 Cancer Prev Res (Phila) 2024 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/37967575
Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice. Forsyth CB, Shaikh M, Engen PA, Preuss F, Naqib A, Palmen BA, Green SJ, Zhang L, Bogin ZR, Lawrence K, Sharma D, Swanson GR, Bishehsari F, Voigt RM, Keshavarzian A Frontiers in aging 38501032 Front Aging 2024 https://www.ncbi.nlm.nih.gov/pubmed/38501032
A Patient-Derived Organ-on-Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer. Adnan D, de Barros NR, Santovito LS, Cheng X, Lawrence KM, Barnett MK, Boetto MD, Mehta N, Singh A, Cheng L, Huang X, Bishehsari F Advanced science (Weinheim, Baden-Wurttemberg, Germany) 41610338 Adv Sci (Weinh) 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41610338
Defining and detecting global transcriptional amplitude in circadian gene expression. Saint-Antoine M, Anafi RC bioRxiv : the preprint server for biology 41292949 bioRxiv 2025 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/41292949
Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R Proceedings of the National Academy of Sciences of the United States of America 31431536 Proc Natl Acad Sci U S A 2019 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/31431536
Rapid generation of potent antibodies by autonomous hypermutation in yeast. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC bioRxiv : the preprint server for biology 33200136 bioRxiv 2020 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/33200136
Protein design and variant prediction using autoregressive generative models. Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS Nature communications 33893299 Nat Commun 2021 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/33893299
Proteome-wide model for human disease genetics. Orenbuch R, Shearer CA, Kollasch AW, Spinner AD, Hopf T, van Niekerk L, Franceschi D, Dias M, Frazer J, Marks DS Nature genetics 41286104 Nat Genet 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41286104
The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families. Smith JS, Hilibrand AS, Skiba MA, Dates AN, Calvillo-Miranda VG, Kruse AC Molecular pharmacology 38641412 Mol Pharmacol 2024 May 17 https://www.ncbi.nlm.nih.gov/pubmed/38641412
Evolutionary-Scale Enzymology Enables Biochemical Constant Prediction Across a Multi-Peaked Catalytic Landscape. Muir DF, Asper GPR, Notin P, Posner JA, Marks DS, Keiser MJ, Pinney MM bioRxiv : the preprint server for biology 39484523 bioRxiv 2024 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/39484523
Continuous evolution of user-defined genes at 1 million times the genomic mutation rate. Rix G, Williams RL, Hu VJ, Spinner A, Pisera AO, Marks DS, Liu CC Science (New York, N.Y.) 39509492 Science 2024 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/39509492
Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning. Silverstein RA, Kim N, Kroell AS, Walton RT, Delano J, Butcher RM, Pacesa M, Smith BK, Christie KA, Ha LL, Meis RJ, Clark AB, Spinner AD, Lazzarotto CR, Li Y, Matsubara A, Urbina EO, Dahl GA, Correia BE, Marks DS, Tsai SQ, Pinello L, De Ravin SS, Liu Q, Kleinstiver BP Nature 40262634 Nature 2025 Jul https://www.ncbi.nlm.nih.gov/pubmed/40262634
Proteome-wide model for human disease genetics. Orenbuch R, Shearer CA, Kollasch AW, Spinner HD, Hopf TA, van Niekerk L, Franceschi D, Dias M, Frazer J, Marks DS medRxiv : the preprint server for health sciences 38076790 medRxiv 2025 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/38076790
Discovery of VH domains that allosterically inhibit ENPP1. Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA Nature chemical biology 37400538 Nat Chem Biol 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37400538
Rapidly inducible yeast surface display for antibody evolution with OrthoRep. Paulk AM, Williams RL, Liu CC bioRxiv : the preprint server for biology 38826191 bioRxiv 2024 May 24 https://www.ncbi.nlm.nih.gov/pubmed/38826191
An in silico method to assess antibody fragment polyreactivity. Harvey EP, Shin JE, Skiba MA, Nemeth GR, Hurley JD, Wellner A, Shaw AY, Miranda VG, Min JK, Liu CC, Marks DS, Kruse AC Nature communications 36477674 Nat Commun 2022 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/36477674
ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction. Notin P, Kollasch AW, Ritter D, van Niekerk L, Paul S, Spinner H, Rollins N, Shaw A, Weitzman R, Frazer J, Dias M, Franceschi D, Orenbuch R, Gal Y, Marks DS bioRxiv : the preprint server for biology 38106144 bioRxiv 2023 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/38106144
ProteinNPT: Improving Protein Property Prediction and Design with Non-Parametric Transformers. Notin P, Marks DS, Weitzman R, Gal Y bioRxiv : the preprint server for biology 38106034 bioRxiv 2023 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/38106034
Protein design using structure-based residue preferences. Ding D, Shaw AY, Sinai S, Rollins N, Prywes N, Savage DF, Laub MT, Marks DS Nature communications 38388493 Nat Commun 2024 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/38388493
Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape. Muir DF, Asper GPR, Notin P, Posner JA, Marks DS, Keiser MJ, Pinney MM Science (New York, N.Y.) 40504906 Science 2025 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/40504906
β-arrestin recruitment facilitates a direct association with G proteins. Lee CY, Smith JS, Kohlmann T, Meara EM, Pham U, Kwarcinski F, Dates AN, Choi I, Hilibrand AS, Gillikin A, Blacklow SC, Tall GG, Kruse AC, Rajagopal S bioRxiv : the preprint server for biology 40631328 bioRxiv 2025 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/40631328
Ultra-efficient Integration of Gene Libraries onto Yeast Cytosolic Plasmids. Pisera AO, Yu Y, Williams RL, Liu CC ACS synthetic biology 40127237 ACS Synth Biol 2025 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/40127237
Machine learning enables efficient and effective affinity maturation of nanobodies. Paul S, Harvey EP, Osei-Owusu J, Kollasch AW, Riesselman AJ, McMahon C, Gazizov A, Anuganti M, Belay F, Kieu MA, Zhu H, Hollingsworth LR, Harper JW, Moshinsky DJ, Teixeira AAR, Marks DS, Kruse AC bioRxiv : the preprint server for biology 41648218 bioRxiv 2026 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/41648218
Co-evolution of interacting proteins through non-contacting and non-specific mutations. Ding D, Green AG, Wang B, Lite TV, Weinstein EN, Marks DS, Laub MT Nature ecology & evolution 35361892 Nat Ecol Evol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35361892
Atomically accurate de novo design of antibodies with RFdiffusion. Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R, Yu Y, Shrock EL, Ault R, Leung PJY, Huang B, Goreshnik I, Tam J, Carr KD, Singer B, Criswell C, Wicky BIM, Vafeados D, Sanchez MG, Kim HM, Torres SV, Chan S, Sun SM, Spear T, Sun Y, O'Reilly K, Maris JM, Sgourakis NG, Melnyk RA, Liu CC, Baker D bioRxiv : the preprint server for biology 38562682 bioRxiv 2025 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/38562682
Guidelines for releasing a variant effect predictor. Livesey BJ, Badonyi M, Dias M, Frazer J, Kumar S, Lindorff-Larsen K, McCandlish DM, Orenbuch R, Shearer CA, Muffley L, Foreman J, Glazer AM, Lehner B, Marks DS, Roth FP, Rubin AF, Starita LM, Marsh JA ArXiv 38699161 ArXiv 2024 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/38699161
Epitope-directed selection of GPCR nanobody ligands with evolvable function. Skiba MA, Canavan C, Nemeth GR, Liu J, Kanso A, Kruse AC Proceedings of the National Academy of Sciences of the United States of America 40067891 Proc Natl Acad Sci U S A 2025 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/40067891
Rapidly Inducible Yeast Surface Display for Antibody Evolution with OrthoRep. Paulk AM, Williams RL, Liu CC ACS synthetic biology 39052526 ACS Synth Biol 2024 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/39052526
G Protein Selectivity in Dopamine Receptors is Determined before GDP Release. Tawfeeq C, Hilibrand AS, Smith JS, Portillo J, Kruse AC, Abrol R Biochemistry 40358213 Biochemistry 2025 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/40358213
Decoding protein-peptide interactions using a large, target-agnostic yeast surface display library. Hurley JD, Shlosman I, Lakshminarayan M, Zhao Z, Yue H, Nowak RP, Fischer ES, Kruse AC bioRxiv : the preprint server for biology 40475574 bioRxiv 2025 May 23 https://www.ncbi.nlm.nih.gov/pubmed/40475574
Rapid generation of potent antibodies by autonomous hypermutation in yeast. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC Nature chemical biology 34168368 Nat Chem Biol 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34168368
Antibodies expand the scope of angiotensin receptor pharmacology. Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC Nature chemical biology 38744986 Nat Chem Biol 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/38744986
The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC Nature chemical biology 37081311 Nat Chem Biol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37081311
An Atlas of Variant Effects to understand the genome at nucleotide resolution. Fowler DM, Adams DJ, Gloyn AL, Hahn WC, Marks DS, Muffley LA, Neal JT, Roth FP, Rubin AF, Starita LM, Hurles ME Genome biology 37394429 Genome Biol 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/37394429
Continuous evolution of user-defined genes at 1-million-times the genomic mutation rate. Rix G, Williams RL, Spinner H, Hu VJ, Marks DS, Liu CC bioRxiv : the preprint server for biology 38014077 bioRxiv 2023 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/38014077
Deep generative modeling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders. Orenbuch R, Kollasch AW, Spinner HD, Shearer CA, Hopf TA, Franceschi D, Dias M, Frazer J, Marks DS Research square 38260496 Res Sq 2024 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/38260496
Antibodies Expand the Scope of Angiotensin Receptor Pharmacology. Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC bioRxiv : the preprint server for biology 37662341 bioRxiv 2023 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/37662341
Learning from prepandemic data to forecast viral escape. Thadani NN, Gurev S, Notin P, Youssef N, Rollins NJ, Ritter D, Sander C, Gal Y, Marks DS Nature 37821700 Nature 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37821700
Guidelines for releasing a variant effect predictor. Livesey BJ, Badonyi M, Dias M, Frazer J, Kumar S, Lindorff-Larsen K, McCandlish DM, Orenbuch R, Shearer CA, Muffley L, Foreman J, Glazer AM, Lehner B, Marks DS, Roth FP, Rubin AF, Starita LM, Marsh JA Genome biology 40234898 Genome Biol 2025 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/40234898
Atomically accurate de novo design of antibodies with RFdiffusion. Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidle C, Biswas R, Yu Y, Shrock EL, Ault R, Leung PJY, Huang B, Goreshnik I, Tam J, Carr KD, Singer B, Criswell C, Wicky BIM, Vafeados D, Garcia Sanchez M, Kim HM, Vázquez Torres S, Chan S, Sun SM, Spear TT, Sun Y, O'Reilly K, Maris JM, Sgourakis NG, Melnyk RA, Liu CC, Baker D Nature 41193805 Nature 2026 Jan https://www.ncbi.nlm.nih.gov/pubmed/41193805
Metal Ion Requirement for Catalysis by 3'-5' RNA Polymerases. Iwaniec BWJ, Allegretti MM, Jackman JE Biochemistry 40774528 Biochemistry 2025 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/40774528
Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity. Boys IN, Johnson AG, Quinlan MR, Kranzusch PJ, Elde NC Cell reports 37494187 Cell Rep 2023 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/37494187
C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA. Consalvo CD, Aderounmu AM, Donelick HM, Aruscavage PJ, Eckert DM, Shen PS, Bass BL bioRxiv : the preprint server for biology 37790392 bioRxiv 2024 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/37790392
Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses. Boys IN, Johnson AG, Quinlan M, Kranzusch PJ, Elde NC bioRxiv : the preprint server for biology 36909515 bioRxiv 2023 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/36909515
A comparison of Dictyostelium discoideum 3'-5' RNA polymerases reveals a conserved tRNA(His) guanylyltransferase residue that plays a dual role in catalysis. Johnecheck GN, Kihm KJ, Jackman JE bioRxiv : the preprint server for biology 41279222 bioRxiv 2025 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/41279222
The competitive landscape of the dsRNA world. Cottrell KA, Andrews RJ, Bass BL Molecular cell 38118451 Mol Cell 2024 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/38118451
Thg1 family 3'-5' RNA polymerases as tools for targeted RNA synthesis. Jayasinghe MI, Patel KJ, Jackman JE RNA (New York, N.Y.) 38997129 RNA 2024 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/38997129
Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA. Consalvo CD, Aderounmu AM, Donelick HM, Aruscavage PJ, Eckert DM, Shen PS, Bass BL eLife 38747717 Elife 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/38747717
Detection of Orsay viral replication intermediates reveals spatial and regulatory links to Caenorhabditis elegans innate immune responses. Ranganathan S, Aruscavage PJ, Bass BL bioRxiv : the preprint server for biology 41000914 bioRxiv 2025 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/41000914
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation. Lai LB, Jackman JE, Daniels CJ, Gopalan V Trends in biochemical sciences 40581570 Trends Biochem Sci 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40581570
Ancestral protein reconstruction reveals evolutionary events governing variation in Dicer helicase function. Aderounmu AM, Aruscavage PJ, Kolaczkowski B, Bass BL eLife 37068011 Elife 2023 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/37068011
A trove of antiviral TRIM family E3 ligases in reptiles. Boys IN, Quinlan MR, Elde NC bioRxiv : the preprint server for biology 40667304 bioRxiv 2025 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/40667304
Metal ion requirement for catalysis by 3'-5' RNA polymerases. Iwaniec BWJ, Allegretti MM, Jackman JE bioRxiv : the preprint server for biology 40166239 bioRxiv 2025 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/40166239
Characterization of Orsay virus replication intermediates in Caenorhabditis elegans reveals links to antiviral RNA interference. Ranganathan S, Aruscavage PJ, Bass BL Molecular biology of the cell 41705949 Mol Biol Cell 2026 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/41705949
The Complexities and Nuances of Analyzing the Genome of Drosophila ananassae and Its Wolbachia Endosymbiont. Dunning Hotopp JC, Klasson L G3 (Bethesda, Md.) 29301977 G3 (Bethesda) 2018 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/29301977
Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication. Scarpa M, Kapoor S, Tvedte ES, Doshi KA, Zou YS, Singh P, Lee JK, Chatterjee A, Ali MKM, Bromley RE, Hotopp JCD, Rassool FV, Baer MR Oncotarget 34504649 Oncotarget 2021 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/34504649
Accumulation of endosymbiont genomes in an insect autosome followed by endosymbiont replacement. Tvedte ES, Gasser M, Zhao X, Tallon LJ, Sadzewicz L, Bromley RE, Chung M, Mattick J, Sparklin BC, Dunning Hotopp JC Current biology : CB 35671755 Curr Biol 2022 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/35671755
Comparison of long-read sequencing technologies in interrogating bacteria and fly genomes. Tvedte ES, Gasser M, Sparklin BC, Michalski J, Hjelmen CE, Johnston JS, Zhao X, Bromley R, Tallon LJ, Sadzewicz L, Rasko DA, Dunning Hotopp JC G3 (Bethesda, Md.) 33768248 G3 (Bethesda) 2021 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/33768248
Cost effective, experimentally robust differential-expression analysis for human/mammalian, pathogen and dual-species transcriptomics. Shetty AC, Mattick J, Chung M, McCracken C, Mahurkar A, Filler SG, Fraser CM, Rasko DA, Bruno VM, Dunning Hotopp JC Microbial genomics 31851607 Microb Genom 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31851607
Grafting or pruning in the animal tree: lateral gene transfer and gene loss? Dunning Hotopp JC BMC genomics 29914363 BMC Genomics 2018 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/29914363
Aligner optimization increases accuracy and decreases compute times in multi-species sequence data. Robinson KM, Hawkins AS, Santana-Cruz I, Adkins RS, Shetty AC, Nagaraj S, Sadzewicz L, Tallon LJ, Rasko DA, Fraser CM, Mahurkar A, Silva JC, Dunning Hotopp JC Microbial genomics 29114401 Microb Genom 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/29114401
Updated annotation and meta-analysis of Brugia malayi transcriptomics data reveals consistent transcriptional profiles across time and space with some study-specific differences in adult female worm transcriptional profiles. Holt CI, Dunning Hotopp JC PLoS neglected tropical diseases 39325836 PLoS Negl Trop Dis 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39325836
Modeling the integration of bacterial rRNA fragments into the human cancer genome. Sieber KB, Gajer P, Dunning Hotopp JC BMC bioinformatics 27001685 BMC Bioinformatics 2016 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/27001685
Complete Genome Sequence of wAna, the Wolbachia Endosymbiont of Drosophila ananassae. Gasser MT, Chung M, Bromley RE, Nadendla S, Dunning Hotopp JC Microbiology resource announcements 31649084 Microbiol Resour Announc 2019 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/31649084
Distinguishing potential bacteria-tumor associations from contamination in a secondary data analysis of public cancer genome sequence data. Robinson KM, Crabtree J, Mattick JS, Anderson KE, Dunning Hotopp JC Microbiome 28118849 Microbiome 2017 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/28118849
Best Practices for Successfully Writing and Publishing a Genome Announcement in Microbiology Resource Announcements. Dunning Hotopp JC, Baltrus DA, Bruno VM, Dennehy JJ, Gill SR, Maresca JA, Matthijnssens J, Newton ILG, Putonti C, Rasko DA, Rokas A, Roux S, Stajich JE, Stedman KM, Stewart FJ, Thrash JC Microbiology resource announcements 32883786 Microbiol Resour Announc 2020 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/32883786
TwinBLAST: When Two Is Better than One. Dunning Hotopp JC, Matsumura J, Bromley RE, Riley DR, Agrawal S, Sparklin B, Mattick J, Crabtree J, Mahurkar A Microbiology resource announcements 31467106 Microbiol Resour Announc 2019 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/31467106
Ancestral characterization of 1018 cancer cell lines highlights disparities and reveals gene expression and mutational differences. Kessler MD, Bateman NW, Conrads TP, Maxwell GL, Dunning Hotopp JC, O'Connor TD Cancer 30865299 Cancer 2019 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/30865299
Lateral gene transfer between prokaryotes and eukaryotes. Sieber KB, Bromley RE, Dunning Hotopp JC Experimental cell research 28189637 Exp Cell Res 2017 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/28189637
Innovations in Instrumentation for Positron Emission Tomography. Berg E, Cherry SR Seminars in nuclear medicine 29852942 Semin Nucl Med 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29852942
Total-Body Quantitative Parametric Imaging of Early Kinetics of (18)F-FDG. Feng T, Zhao Y, Shi H, Li H, Zhang X, Wang G, Price PM, Badawi RD, Cherry SR, Jones T Journal of nuclear medicine : official publication, Society of Nuclear Medicine 32948679 J Nucl Med 2021 May 10 https://www.ncbi.nlm.nih.gov/pubmed/32948679
Oncologic Applications of Long Axial Field-of-View PET/Computed Tomography. Nardo L, Pantel AR PET clinics 33218605 PET Clin 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33218605
Numerical observer study of lesion detectability for a long axial field-of-view whole-body PET imager using the PennPET Explorer. Viswanath V, Daube Witherspoon ME, Karp JS, Surti S Physics in medicine and biology 31816616 Phys Med Biol 2020 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/31816616
Quantitative accuracy in total-body imaging using the uEXPLORER PET/CT scanner. Leung EK, Berg E, Omidvari N, Spencer BA, Li E, Abdelhafez YG, Schmall JP, Liu W, He L, Tang S, Liu Y, Dong Y, Jones T, Cherry SR, Badawi RD Physics in medicine and biology 34544074 Phys Med Biol 2021 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/34544074
PET Parametric Imaging: Past, Present, and Future. Wang G, Rahmim A, Gunn RN IEEE transactions on radiation and plasma medical sciences 33763624 IEEE Trans Radiat Plasma Med Sci 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33763624
Exploring Vessel Wall Biology In Vivo by Ultrasensitive Total-Body PET. Derlin T, Spencer BA, Mamach M, Abdelhafez Y, Nardo L, Badawi RD, Cherry SR, Bengel FM Journal of nuclear medicine : official publication, Society of Nuclear Medicine 36175139 J Nucl Med 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36175139
Performance Characteristics of Long Axial Field-of-View PET Scanners with Axial Gaps. Daube-Witherspoon ME, Viswanath V, Werner ME, Karp JS IEEE transactions on radiation and plasma medical sciences 34179595 IEEE Trans Radiat Plasma Med Sci 2021 May https://www.ncbi.nlm.nih.gov/pubmed/34179595
Beyond skin deep: total-body positron emission tomography to illuminate systemic inflammation in psoriatic arthritis. Chaudhari AJ, Abdelhafez YG, Nardo L, Raychaudhuri SP Current opinion in immunology 40543379 Curr Opin Immunol 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40543379
Optimization-derived blood input function using a kernel method and its evaluation with total-body PET for brain parametric imaging. Zhu Y, Tran Q, Wang Y, Badawi RD, Cherry SR, Qi J, Abbaszadeh S, Wang G NeuroImage 38643890 Neuroimage 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38643890
Multimodal positron emission tomography (PET) imaging in non-oncologic musculoskeletal radiology. Kogan F, Yoon D, Teeter MG, Chaudhari AJ, Hales L, Barbieri M, Gold GE, Vainberg Y, Goyal A, Watkins L Skeletal radiology 38492029 Skeletal Radiol 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38492029
Total-Body (18)F-FDG PET/CT in Autoimmune Inflammatory Arthritis at Ultra-Low Dose: Initial Observations. Abdelhafez Y, Raychaudhuri SP, Mazza D, Sarkar S, Hunt HL, McBride K, Nguyen M, Caudle DT, Spencer BA, Omidvari N, Bang H, Cherry SR, Nardo L, Badawi RD, Chaudhari AJ Journal of nuclear medicine : official publication, Society of Nuclear Medicine 35589405 J Nucl Med 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35589405
Facial Anonymization and Privacy Concerns in Total-Body PET/CT. Selfridge AR, Spencer BA, Abdelhafez YG, Nakagawa K, Tupin JD, Badawi RD Journal of nuclear medicine : official publication, Society of Nuclear Medicine 37268426 J Nucl Med 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37268426
Total-Body Multiparametric PET Quantification of (18)F-FDG Delivery and Metabolism in the Study of Coronavirus Disease 2019 Recovery. Wang Y, Nardo L, Spencer BA, Abdelhafez YG, Li EJ, Omidvari N, Chaudhari AJ, Badawi RD, Jones T, Cherry SR, Wang G Journal of nuclear medicine : official publication, Society of Nuclear Medicine 37591539 J Nucl Med 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37591539
First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody. Omidvari N, Jones T, Price PM, Ferre AL, Lu J, Abdelhafez YG, Sen F, Cohen SH, Schmiedehausen K, Badawi RD, Shacklett BL, Wilson I, Cherry SR Science advances 37824612 Sci Adv 2023 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/37824612
Total-Body Dynamic Reconstruction and Parametric Imaging on the uEXPLORER. Zhang X, Xie Z, Berg E, Judenhofer MS, Liu W, Xu T, Ding Y, Lv Y, Dong Y, Deng Z, Tang S, Shi H, Hu P, Chen S, Bao J, Li H, Zhou J, Wang G, Cherry SR, Badawi RD, Qi J Journal of nuclear medicine : official publication, Society of Nuclear Medicine 31302637 J Nucl Med 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31302637
Scanner Design Considerations for Long Axial Field-of-View PET Systems. Daube-Witherspoon ME, Cherry SR PET clinics 33160929 PET Clin 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33160929
Update on the PennPET Explorer: A Whole-body Imager with Scalable Axial Field-of-View. Pantel AR, Viswanath V, Karp JS PET clinics 33218602 PET Clin 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33218602
3D/4D Reconstruction and Quantitative Total Body Imaging. Qi J, Matej S, Wang G, Zhang X PET clinics 33218603 PET Clin 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33218603
Development and Evaluation of mini-EXPLORER: A Long Axial Field-of-View PET Scanner for Nonhuman Primate Imaging. Berg E, Zhang X, Bec J, Judenhofer MS, Patel B, Peng Q, Kapusta M, Schmand M, Casey ME, Tarantal AF, Qi J, Badawi RD, Cherry SR Journal of nuclear medicine : official publication, Society of Nuclear Medicine 29419483 J Nucl Med 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29419483
Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning. Lv Y, Lv X, Liu W, Judenhofer MS, Zwingenberger A, Wisner E, Berg E, McKenney S, Leung E, Spencer BA, Cherry SR, Badawi RD Physics in medicine and biology 30620929 Phys Med Biol 2019 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/30620929
PennPET Explorer: Human Imaging on a Whole-Body Imager. Pantel AR, Viswanath V, Daube-Witherspoon ME, Dubroff JG, Muehllehner G, Parma MJ, Pryma DA, Schubert EK, Mankoff DA, Karp JS Journal of nuclear medicine : official publication, Society of Nuclear Medicine 31562224 J Nucl Med 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31562224
Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care. Cherry SR, Jones T, Karp JS, Qi J, Moses WW, Badawi RD Journal of nuclear medicine : official publication, Society of Nuclear Medicine 28935835 J Nucl Med 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28935835
Total-body imaging: Transforming the role of positron emission tomography. Cherry SR, Badawi RD, Karp JS, Moses WW, Price P, Jones T Science translational medicine 28298419 Sci Transl Med 2017 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/28298419
Reaching 200-ps timing resolution in a time-of-flight and depth-of-interaction positron emission tomography detector using phosphor-coated crystals and high-density silicon photomultipliers. Kwon SI, Ferri A, Gola A, Berg E, Piemonte C, Cherry SR, Roncali E Journal of medical imaging (Bellingham, Wash.) 27921069 J Med Imaging (Bellingham) 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27921069
First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody. Omidvari N, Jones T, Price PM, Ferre AL, Lu J, Abdelhafez YG, Sen F, Cohen SH, Schmiedehausen K, Badawi RD, Shacklett BL, Wilson I, Cherry SR medRxiv : the preprint server for health sciences 36993568 medRxiv 2023 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/36993568
Quantitative PET imaging and modeling of molecular blood-brain barrier permeability. Chung KJ, Abdelhafez YG, Spencer BA, Jones T, Tran Q, Nardo L, Chen MS Jr, Sarkar S, Medici V, Lyo V, Badawi RD, Cherry SR, Wang G Nature communications 40159510 Nat Commun 2025 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/40159510
Total-body positron emission tomography: a tool for systemic, quantitative evaluation of the inflammatory burden of psoriatic arthritis. Raychaudhuri SP, Abdelhafez YG, Mazza DF, Raychaudhuri SK, Cherry SR, Nardo L, Badawi RD, Chaudhari AJ Rheumatology (Oxford, England) 39714258 Rheumatology (Oxford) 2025 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/39714258
Parallax error in long-axial field-of-view PET scanners-a simulation study. Schmall JP, Karp JS, Werner M, Surti S Physics in medicine and biology 27367971 Phys Med Biol 2016 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/27367971
First Human Imaging Studies with the EXPLORER Total-Body PET Scanner. Badawi RD, Shi H, Hu P, Chen S, Xu T, Price PM, Ding Y, Spencer BA, Nardo L, Liu W, Bao J, Jones T, Li H, Cherry SR Journal of nuclear medicine : official publication, Society of Nuclear Medicine 30733314 J Nucl Med 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30733314
Theoretical study of the benefit of long axial field-of-view PET on region of interest quantification. Zhang X, Badawi RD, Cherry SR, Qi J Physics in medicine and biology 29799814 Phys Med Biol 2018 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/29799814
Performance assessment of a software-based coincidence processor for the EXPLORER total-body PET scanner. Leung EK, Judenhofer MS, Cherry SR, Badawi RD Physics in medicine and biology 30152793 Phys Med Biol 2018 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/30152793
Practical joint reconstruction of activity and attenuation with autonomous scaling for time-of-flight PET. Li Y, Matej S, Karp JS Physics in medicine and biology 32340014 Phys Med Biol 2020 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/32340014
Performance Evaluation of the uEXPLORER Total-Body PET/CT Scanner Based on NEMA NU 2-2018 with Additional Tests to Characterize PET Scanners with a Long Axial Field of View. Spencer BA, Berg E, Schmall JP, Omidvari N, Leung EK, Abdelhafez YG, Tang S, Deng Z, Dong Y, Lv Y, Bao J, Liu W, Li H, Jones T, Badawi RD, Cherry SR Journal of nuclear medicine : official publication, Society of Nuclear Medicine 33008932 J Nucl Med 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/33008932
Total-Body PET Kinetic Modeling and Potential Opportunities Using Deep Learning. Wang Y, Li E, Cherry SR, Wang G PET clinics 34353745 PET Clin 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34353745
Total Body PET: Why, How, What for? Surti S, Pantel AR, Karp JS IEEE transactions on radiation and plasma medical sciences 33134653 IEEE Trans Radiat Plasma Med Sci 2020 May https://www.ncbi.nlm.nih.gov/pubmed/33134653
Total-body PET/CT - First Clinical Experiences and Future Perspectives. Ng QK, Triumbari EKA, Omidvari N, Cherry SR, Badawi RD, Nardo L Seminars in nuclear medicine 35272853 Semin Nucl Med 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35272853
Total-body Dynamic Imaging and Kinetic Modeling of (18)F-AraG in Healthy Individuals and a Non-Small Cell Lung Cancer Patient Undergoing Anti-PD-1 Immunotherapy. Omidvari N, Levi J, Abdelhafez YG, Wang Y, Nardo L, Daly ME, Wang G, Cherry SR medRxiv : the preprint server for health sciences 37790461 medRxiv 2023 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/37790461
Cloud-based serverless computing enables accelerated monte carlo simulations for nuclear medicine imaging. Bayerlein R, Swarnakar V, Selfridge A, Spencer BA, Nardo L, Badawi RD Biomedical physics & engineering express 38876087 Biomed Phys Eng Express 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38876087
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative. Ferrara D, Pires M, Gutschmayer S, Yu J, Abdelhafez YG, Abenavoli E, Badawi RD, Chaudhari AJ, Chen MS Jr, Cherry SR, Frille A, Geist BK, Gruenert S, Hacker M, Hesse S, Kerkhoff T, Linder P, Pappisch J, Pusitz S, Raslan OA, Rausch I, Raychaudhuri SP, Sabri O, Schmidt F, Sciagrà R, Spencer B, Wang G, Wirtz H, Beyer T, Sundar LKS Research square 40799763 Res Sq 2025 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/40799763
Advances in PET Diagnostics for Guiding Targeted Cancer Therapy and Studying In Vivo Cancer Biology. Mankoff DA, Pantel AR, Viswanath V, Karp JS Current pathobiology reports 37092138 Curr Pathobiol Rep 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/37092138
The role of brown adipose tissue in branched-chain amino acid clearance in people. Abdelhafez YG, Wang G, Li S, Pellegrinelli V, Chaudhari AJ, Ramirez A, Sen F, Vidal-Puig A, Sidossis LS, Klein S, Badawi RD, Chondronikola M iScience 39175781 iScience 2024 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/39175781
Quantitative Total-Body Imaging of Blood Flow with High Temporal Resolution Early Dynamic (18)F-Fluorodeoxyglucose PET Kinetic Modeling. Chung KJ, Chaudhari AJ, Nardo L, Jones T, Chen MS Jr, Badawi RD, Cherry SR, Wang G medRxiv : the preprint server for health sciences 39252929 medRxiv 2024 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/39252929
Quantitative image reconstruction for total-body PET imaging using the 2-meter long EXPLORER scanner. Zhang X, Zhou J, Cherry SR, Badawi RD, Qi J Physics in medicine and biology 28240215 Phys Med Biol 2017 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/28240215
Subsecond total-body imaging using ultrasensitive positron emission tomography. Zhang X, Cherry SR, Xie Z, Shi H, Badawi RD, Qi J Proceedings of the National Academy of Sciences of the United States of America 31964808 Proc Natl Acad Sci U S A 2020 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/31964808
Lutetium background radiation in total-body PET-A simulation study on opportunities and challenges in PET attenuation correction. Omidvari N, Cheng L, Leung EK, Abdelhafez YG, Badawi RD, Ma T, Qi J, Cherry SR Frontiers in nuclear medicine 36172601 Front Nucl Med 2022 https://www.ncbi.nlm.nih.gov/pubmed/36172601
Quantitative PET imaging and modeling of molecular blood-brain barrier permeability. Chung KJ, Abdelhafez YG, Spencer BA, Jones T, Tran Q, Nardo L, Chen MS Jr, Sarkar S, Medici V, Lyo V, Badawi RD, Cherry SR, Wang G medRxiv : the preprint server for health sciences 39108503 medRxiv 2024 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/39108503
Role of Total Body PET/CT in Inflammatory Disorders. Zoghi S, Mingels C, Badawi RD, Spencer BA, Yarbrough TL, Nardo L, Chaudhari AJ Seminars in nuclear medicine 39578110 Semin Nucl Med 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39578110
Clinical Implementation of Total-Body PET/CT at University of California, Davis. Nardo L, Abdelhafez YG, Spencer BA, Badawi RD PET clinics 33218600 PET Clin 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33218600
Analysis of Four-Dimensional Data for Total Body PET Imaging. Viswanath V, Chitalia R, Pantel AR, Karp JS, Mankoff DA PET clinics 33218604 PET Clin 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33218604
Quantitative PET in the 2020s: a roadmap. Meikle SR, Sossi V, Roncali E, Cherry SR, Banati R, Mankoff D, Jones T, James M, Sutcliffe J, Ouyang J, Petibon Y, Ma C, El Fakhri G, Surti S, Karp JS, Badawi RD, Yamaya T, Akamatsu G, Schramm G, Rezaei A, Nuyts J, Fulton R, Kyme A, Lois C, Sari H, Price J, Boellaard R, Jeraj R, Bailey DL, Eslick E, Willowson KP, Dutta J Physics in medicine and biology 33339012 Phys Med Biol 2021 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/33339012
PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager. Karp JS, Viswanath V, Geagan MJ, Muehllehner G, Pantel AR, Parma MJ, Perkins AE, Schmall JP, Werner ME, Daube-Witherspoon ME Journal of nuclear medicine : official publication, Society of Nuclear Medicine 31227573 J Nucl Med 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31227573
Impact of event positioning algorithm on performance of a whole-body PET scanner using one-to-one coupled detectors. Surti S, Karp JS Physics in medicine and biology 29411709 Phys Med Biol 2018 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/29411709
Total-Body Multiparametric PET Quantification of (18) F-FDG Delivery and Metabolism in the Study of COVID-19 Recovery. Wang Y, Nardo L, Spencer BA, Abdelhafez YG, Li EJ, Omidvari N, Chaudhari AJ, Badawi RD, Jones T, Cherry SR, Wang G medRxiv : the preprint server for health sciences 37034643 medRxiv 2023 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/37034643
High-Temporal-Resolution Lung Kinetic Modeling Using Total-Body Dynamic PET with Time-Delay and Dispersion Corrections. Wang Y, Spencer BA, Schmall J, Li E, Badawi RD, Jones T, Cherry SR, Wang G Journal of nuclear medicine : official publication, Society of Nuclear Medicine 37116916 J Nucl Med 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37116916
Relating(18)F-FDG image signal-to-noise ratio to time-of-flight noise-equivalent count rate in total-body PET using the uEXPLORER scanner. Leung EK, Abdelhafez YG, Berg E, Xie Z, Zhang X, Bayerlein R, Spencer B, Li E, Omidvari N, Selfridge A, Cherry SR, Qi J, Badawi RD Physics in medicine and biology 35609588 Phys Med Biol 2022 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/35609588
EXPLORing Arthritis with Total-body Positron Emission Tomography. Chaudhari AJ, Abdelhafez YG, Nardo L, Raychaudhuri SP Seminars in musculoskeletal radiology 37935209 Semin Musculoskelet Radiol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37935209
Total-Body Perfusion Imaging with [(11)C]-Butanol. Li EJ, López JE, Spencer BA, Abdelhafez Y, Badawi RD, Wang G, Cherry SR Journal of nuclear medicine : official publication, Society of Nuclear Medicine 37652544 J Nucl Med 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37652544
Numerical investigation reveals challenges in measuring the contrast recovery coefficients in PET. Bayerlein R, Spencer BA, Abdelhafez YG, Cherry SR, Badawi RD, Omidvari N Physics in medicine and biology 37802064 Phys Med Biol 2023 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/37802064
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A Scientific reports 28389661 Sci Rep 2017 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/28389661
Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA Cell 27693353 Cell 2016 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/27693353
T cells selectively filter oscillatory signals on the minutes timescale. O'Donoghue GP, Bugaj LJ, Anderson W, Daniels KG, Rawlings DJ, Lim WA Proceedings of the National Academy of Sciences of the United States of America 33627405 Proc Natl Acad Sci U S A 2021 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/33627405
Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies. Dannenfelser R, Allen GM, VanderSluis B, Koegel AK, Levinson S, Stark SR, Yao V, Tadych A, Troyanskaya OG, Lim WA Cell systems 32916097 Cell Syst 2020 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/32916097
Engineering cytokines and cytokine circuits. Li AW, Lim WA Science (New York, N.Y.) 33243875 Science 2020 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/33243875
Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA Science (New York, N.Y.) 33243890 Science 2020 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/33243890
The Principles of Engineering Immune Cells to Treat Cancer. Lim WA, June CH Cell 28187291 Cell 2017 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/28187291
Modular engineering of cellular signaling proteins and networks. Gordley RM, Bugaj LJ, Lim WA Current opinion in structural biology 27423114 Curr Opin Struct Biol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27423114
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA Science (New York, N.Y.) 36520915 Science 2022 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/36520915
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA Cell 26830879 Cell 2016 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/26830879
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Roybal KT, Lim WA Annual review of immunology 28446063 Annu Rev Immunol 2017 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/28446063
Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. Esensten JH, Bluestone JA, Lim WA Annual review of pathology 27959633 Annu Rev Pathol 2017 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/27959633
Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA Science (New York, N.Y.) 26405231 Science 2015 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/26405231
Synthetic biology approaches to engineer T cells. Wu CY, Rupp LJ, Roybal KT, Lim WA Current opinion in immunology 26218616 Curr Opin Immunol 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26218616
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA Cell 26830878 Cell 2016 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/26830878
T cell circuits that sense antigen density with an ultrasensitive threshold. Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, Tonai Y, De Guzman A, Mäkelä A, Saksela K, Gartner ZJ, Lim WA Science (New York, N.Y.) 33632893 Science 2021 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/33632893
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA Science translational medicine 33910979 Sci Transl Med 2021 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/33910979
Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR. Boettcher M, McManus MT Molecular cell 26000843 Mol Cell 2015 May 21 https://www.ncbi.nlm.nih.gov/pubmed/26000843
Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY Cell 27565350 Cell 2016 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/27565350
Directed Evolution of Split APEX2 Peroxidase. Han Y, Branon TC, Martell JD, Boassa D, Shechner D, Ellisman MH, Ting A ACS chemical biology 30848125 ACS Chem Biol 2019 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/30848125
Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, Xu SL, Branon TC, Ting AY, Bergmann DC eLife 31535972 Elife 2019 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/31535972
A split horseradish peroxidase for the detection of intercellular protein-protein interactions and sensitive visualization of synapses. Martell JD, Yamagata M, Deerinck TJ, Phan S, Kwa CG, Ellisman MH, Sanes JR, Ting AY Nature biotechnology 27240195 Nat Biotechnol 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27240195
Proximity labeling: spatially resolved proteomic mapping for neurobiology. Han S, Li J, Ting AY Current opinion in neurobiology 29125959 Curr Opin Neurobiol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29125959
Atlas of Subcellular RNA Localization Revealed by APEX-Seq. Fazal FM, Han S, Parker KR, Kaewsapsak P, Xu J, Boettiger AN, Chang HY, Ting AY Cell 31230715 Cell 2019 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/31230715
Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, Park CH, Hsu CC, Kim YW, Ko YW, Zhang Z, Zhu JY, Hsiao YC, Branon T, Kaasik K, Saldivar E, Li K, Pasha A, Provart NJ, Burlingame AL, Xu SL, Ting AY, Wang ZY The Plant cell 36660928 Plant Cell 2023 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36660928
Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation. Hung V, Lam SS, Udeshi ND, Svinkina T, Guzman G, Mootha VK, Carr SA, Ting AY eLife 28441135 Elife 2017 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/28441135
Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking. Kaewsapsak P, Shechner DM, Mallard W, Rinn JL, Ting AY eLife 29239719 Elife 2017 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/29239719
Efficient proximity labeling in living cells and organisms with TurboID. Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY Nature biotechnology 30125270 Nat Biotechnol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30125270
Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells. Martell JD, Deerinck TJ, Lam SS, Ellisman MH, Ting AY Nature protocols 28796234 Nat Protoc 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28796234
Proximity Biotinylation as a Method for Mapping Proteins Associated with mtDNA in Living Cells. Han S, Udeshi ND, Deerinck TJ, Svinkina T, Ellisman MH, Carr SA, Ting AY Cell chemical biology 28238724 Cell Chem Biol 2017 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/28238724
An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ Cell 28388416 Cell 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28388416
A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ. Lee MS, Glassman CR, Deshpande NR, Badgandi HB, Parrish HL, Uttamapinant C, Stawski PS, Ting AY, Kuhns MS Immunity 26231119 Immunity 2015 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/26231119
Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2. Hung V, Udeshi ND, Lam SS, Loh KH, Cox KJ, Pedram K, Carr SA, Ting AY Nature protocols 26866790 Nat Protoc 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26866790
Correction to Directed Evolution of Split APEX2 Peroxidase. Han Y, Branon TC, Martell JD, Boassa D, Shechner D, Ellisman MH, Ting A ACS chemical biology 31657543 ACS Chem Biol 2019 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/31657543
Author Correction: Efficient proximity labeling in living cells and organisms with TurboID. Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY Nature biotechnology 31748691 Nat Biotechnol 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31748691
Dependence of optical scattering from Intralipid in gelatin-gel based tissue-mimicking phantoms on mixing temperature and time. Lai P, Xu X, Wang LV Journal of biomedical optics 24604534 J Biomed Opt 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24604534
Near-infrared optical-resolution photoacoustic microscopy. Hai P, Yao J, Maslov KI, Zhou Y, Wang LV Optics letters 25166107 Opt Lett 2014 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/25166107
alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV Theranostics 25553103 Theranostics 2015 https://www.ncbi.nlm.nih.gov/pubmed/25553103
Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light. Liu Y, Lai P, Ma C, Xu X, Grabar AA, Wang LV Nature communications 25556918 Nat Commun 2015 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/25556918
Optical drug monitoring: photoacoustic imaging of nanosensors to monitor therapeutic lithium in vivo. Cash KJ, Li C, Xia J, Wang LV, Clark HA ACS nano 25588028 ACS Nano 2015 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/25588028
Photoacoustic lymphatic imaging with high spatial-temporal resolution. Martel C, Yao J, Huang CH, Zou J, Randolph GJ, Wang LV Journal of biomedical optics 25408958 J Biomed Opt 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25408958
Single-shot compressed ultrafast photography at one hundred billion frames per second. Gao L, Liang J, Li C, Wang LV Nature 25471883 Nature 2014 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/25471883
Single-shot real-time femtosecond imaging of temporal focusing. Liang J, Zhu L, Wang LV Light, science & applications 30839588 Light Sci Appl 2018 https://www.ncbi.nlm.nih.gov/pubmed/30839588
Dual-axis illumination for virtually augmenting the detection view of optical-resolution photoacoustic microscopy. Hsu HC, Li L, Yao J, Wong TTW, Shi J, Chen R, Zhou Q, Wang L Journal of biomedical optics 29981225 J Biomed Opt 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29981225
Small near-infrared photochromic protein for photoacoustic multi-contrast imaging and detection of protein interactions in vivo. Li L, Shemetov AA, Baloban M, Hu P, Zhu L, Shcherbakova DM, Zhang R, Shi J, Yao J, Wang LV, Verkhusha VV Nature communications 30013153 Nat Commun 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30013153
Transvaginal fast-scanning optical-resolution photoacoustic endoscopy. Qu Y, Li C, Shi J, Chen R, Xu S, Rafsanjani H, Maslov K, Krigman H, Garvey L, Hu P, Zhao P, Meyers K, Diveley E, Pizzella S, Muench L, Punyamurthy N, Goldstein N, Onwumere O, Alisio M, Meyenburg K, Maynard J, Helm K, Slaughter J, Barber S, Burger T, Kramer C, Chubiz J, Anderson M, McCarthy R, England SK, Macones GA, Zhou Q, Shung KK, Zou J, Stout MJ, Tuuli M, Wang LV Journal of biomedical optics 30520276 J Biomed Opt 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30520276
Dual-view photoacoustic microscopy for quantitative cell nuclear imaging. Cai D, Wong TTW, Zhu L, Shi J, Chen SL, Wang LV Optics letters 30320772 Opt Lett 2018 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/30320772
Photoacoustic elastography. Hai P, Yao J, Li G, Li C, Wang LV Optics letters 26872173 Opt Lett 2016 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/26872173
In vivo photoacoustic tomography of myoglobin oxygen saturation. Lin L, Yao J, Li L, Wang LV Journal of biomedical optics 26719943 J Biomed Opt 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26719943
Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography. Li L, Zhu L, Shen Y, Wang LV Journal of biomedical optics 28745385 J Biomed Opt 2017 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/28745385
Single-impulse Panoramic Photoacoustic Computed Tomography of Small-animal Whole-body Dynamics at High Spatiotemporal Resolution. Li L, Zhu L, Ma C, Lin L, Yao J, Wang L, Maslov K, Zhang R, Chen W, Shi J, Wang LV Nature biomedical engineering 29333331 Nat Biomed Eng 2017 https://www.ncbi.nlm.nih.gov/pubmed/29333331
Spatiotemporal Antialiasing in Photoacoustic Computed Tomography. Hu P, Li L, Lin L, Wang LV IEEE transactions on medical imaging 32746101 IEEE Trans Med Imaging 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32746101
Harnessing a multi-dimensional fibre laser using genetic wavefront shaping. Wei X, Jing JC, Shen Y, Wang LV Light, science & applications 32884678 Light Sci Appl 2020 https://www.ncbi.nlm.nih.gov/pubmed/32884678
Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo. Li Y, Li L, Zhu L, Shi J, Maslov K, Wang LV Journal of biomedical optics 32648387 J Biomed Opt 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32648387
Integration of Multitargeted Polymer-Based Contrast Agents with Photoacoustic Computed Tomography: An Imaging Technique to Visualize Breast Cancer Intratumor Heterogeneity. Li L, Patil D, Petruncio G, Harnden KK, Somasekharan JV, Paige M, Wang LV, Salvador-Morales C ACS nano 33464827 ACS Nano 2021 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/33464827
Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star. Yang J, Li L, Shemetov AA, Lee S, Zhao Y, Liu Y, Shen Y, Li J, Oka Y, Verkhusha VV, Wang LV Science advances 31844671 Sci Adv 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31844671
Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo. Hai P, Qu Y, Li Y, Zhu L, Shmuylovich L, Cornelius LA, Wang LV Journal of biomedical optics 32170857 J Biomed Opt 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32170857
Cuffing-based photoacoustic flowmetry in humans in the optical diffusive regime. Zhou Y, Liang J, Wang LV Journal of biophotonics 26515158 J Biophotonics 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26515158
Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer. Garcia-Uribe A, Erpelding TN, Krumholz A, Ke H, Maslov K, Appleton C, Margenthaler JA, Wang LV Scientific reports 26510774 Sci Rep 2015 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/26510774
Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe. Yao J, Kaberniuk AA, Li L, Shcherbakova DM, Zhang R, Wang L, Li G, Verkhusha VV, Wang LV Nature methods 26550774 Nat Methods 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26550774
Noninvasive photoacoustic microscopy of methemoglobin in vivo. Tang M, Zhou Y, Zhang R, Wang LV Journal of biomedical optics 25760655 J Biomed Opt 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25760655
Three-dimensional photoacoustic endoscopic imaging of the rabbit esophagus. Yang JM, Favazza C, Yao J, Chen R, Zhou Q, Shung KK, Wang LV PloS one 25874640 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/25874640
In vivo photoacoustic microscopy of human cuticle microvasculature with single-cell resolution. Hsu HC, Wang L, Wang LV Journal of biomedical optics 27207113 J Biomed Opt 2016 May 1 https://www.ncbi.nlm.nih.gov/pubmed/27207113
Grueneisen relaxation photoacoustic microscopy in vivo. Ma J, Shi J, Hai P, Zhou Y, Wang LV Journal of biomedical optics 27272096 J Biomed Opt 2016 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/27272096
Quantitative photoacoustic elastography in humans. Hai P, Zhou Y, Gong L, Wang LV Journal of biomedical optics 27304419 J Biomed Opt 2016 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/27304419
Multiscale Functional and Molecular Photoacoustic Tomography. Yao J, Xia J, Wang LV Ultrasonic imaging 25933617 Ultrason Imaging 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/25933617
In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography. Lin L, Xia J, Wong TT, Li L, Wang LV Journal of biomedical optics 25611865 J Biomed Opt 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25611865
Multiscale Photoacoustic Tomography of a Genetically Encoded Near-Infrared FRET Biosensor. Li L, Hsu HC, Verkhusha VV, Wang LV, Shcherbakova DM Advanced science (Weinheim, Baden-Wurttemberg, Germany) 34533889 Adv Sci (Weinh) 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34533889
Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy. Cao R, Nelson SD, Davis S, Liang Y, Luo Y, Zhang Y, Crawford B, Wang LV Nature biomedical engineering 36123403 Nat Biomed Eng 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36123403
Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo. Li L, Li Y, Zhang Y, Wang LV Nature protocols 33846630 Nat Protoc 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33846630
Single-shot photoacoustic imaging with single-element transducer through a spatiotemporal encoder. Zhao Y, Wang LV Journal of biomedical optics 37065647 J Biomed Opt 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/37065647
Optical-resolution photoacoustic microscopy for volumetric and spectral analysis of histological and immunochemical samples. Zhang YS, Yao J, Zhang C, Li L, Wang LV, Xia Y Angewandte Chemie (International ed. in English) 24961608 Angew Chem Int Ed Engl 2014 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/24961608
Three-dimensional arbitrary trajectory scanning photoacoustic microscopy. Yeh C, Soetikno B, Hu S, Maslov KI, Wang LV Journal of biophotonics 25077689 J Biophotonics 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25077689
The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW Nature immunology 28530712 Nat Immunol 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28530712
Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants. Krenciute G, Prinzing BL, Yi Z, Wu MF, Liu H, Dotti G, Balyasnikova IV, Gottschalk S Cancer immunology research 28550091 Cancer Immunol Res 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28550091
RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A Nature 36002574 Nature 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36002574
Tissue-Resident T Cells in Clinical Response and Immune-Related Adverse Events of Immune Checkpoint Blockade. Zhao Y, Wucherpfennig KW Clinical cancer research : an official journal of the American Association for Cancer Research 39404858 Clin Cancer Res 2024 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/39404858
A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. Pan D, Kobayashi A, Jiang P, Ferrari de Andrade L, Tay RE, Luoma AM, Tsoucas D, Qiu X, Lim K, Rao P, Long HW, Yuan GC, Doench J, Brown M, Liu XS, Wucherpfennig KW Science (New York, N.Y.) 29301958 Science 2018 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/29301958
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, Ashenberg O, Ott PA, Buchbinder EI, Haq R, Hodi FS, Boland GM, Sullivan RJ, Frederick DT, Miao B, Moll T, Flaherty KT, Herlyn M, Jenkins RW, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA, Barbie DA, Shalek AK, Tirosh I, Sorger PK, Wucherpfennig K, Van Allen EM, Schadendorf D, Johnson BE, Rotem A, Rozenblatt-Rosen O, Garraway LA, Yoon CH, Izar B, Regev A Cell 30388455 Cell 2018 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/30388455
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity. Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G Science translational medicine 34788079 Sci Transl Med 2021 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/34788079
Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors. DeRenzo C, Gottschalk S Frontiers in immunology 30828333 Front Immunol 2019 https://www.ncbi.nlm.nih.gov/pubmed/30828333
Polysaccharide-modified scaffolds for controlled lentivirus delivery in vitro and after spinal cord injury. Thomas AM, Shea LD Journal of controlled release : official journal of the Controlled Release Society 23791981 J Control Release 2013 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/23791981
Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Thomas AM, Seidlits SK, Goodman AG, Kukushliev TV, Hassani DM, Cummings BJ, Anderson AJ, Shea LD Integrative biology : quantitative biosciences from nano to macro 24873988 Integr Biol (Camb) 2014 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/24873988
Dynamic transcription factor activity and networks during ErbB2 breast oncogenesis and targeted therapy. Weiss MS, Peñalver Bernabé B, Shin S, Asztalos S, Dubbury SJ, Mui MD, Bellis AD, Bluver D, Tonetti DA, Saez-Rodriguez J, Broadbelt LJ, Jeruss JS, Shea LD Integrative biology : quantitative biosciences from nano to macro 25303361 Integr Biol (Camb) 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25303361
Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography. Spicer GL, Azarin SM, Yi J, Young ST, Ellis R, Bauer GM, Shea LD, Backman V Physics in medicine and biology 27618507 Phys Med Biol 2016 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/27618507
Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes. Oakes RS, Bushnell GG, Orbach SM, Kandagatla P, Zhang Y, Morris AH, Hall MS, LaFaire P, Decker JT, Hartfield RM, Brooks MD, Wicha MS, Jeruss JS, Shea LD Cancer research 31662327 Cancer Res 2020 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/31662327
Controlled release strategies for modulating immune responses to promote tissue regeneration. Dumont CM, Park J, Shea LD Journal of controlled release : official journal of the Controlled Release Society 26264833 J Control Release 2015 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/26264833
Sponge-mediated lentivirus delivery to acute and chronic spinal cord injuries. Thomas AM, Palma JL, Shea LD Journal of controlled release : official journal of the Controlled Release Society 25724274 J Control Release 2015 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/25724274
Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment. Aguado BA, Hartfield RM, Bushnell GG, Decker JT, Azarin SM, Nanavati D, Schipma MJ, Rao SS, Oakes RS, Zhang Y, Jeruss JS, Shea LD Advanced healthcare materials 29521008 Adv Healthc Mater 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29521008
Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor Cells In Vivo. Bushnell GG, Hardas TP, Hartfield RM, Zhang Y, Oakes RS, Ronquist S, Chen H, Rajapakse I, Wicha MS, Jeruss JS, Shea LD Cancer research 30808673 Cancer Res 2019 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/30808673
Label free localization of nanoparticles in live cancer cells using spectroscopic microscopy. Spicer GLC , Almassalha L , Martinez IA , Ellis R , Chandler JE , Gladstein S , Zhang D , Nguyen TQ , Feder S , Subramanian H , de la Rica R , Thompson SA , Backman V Nanoscale 30298892 Nanoscale 2018 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/30298892
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. Dubash AD, Kam CY, Aguado BA, Patel DM, Delmar M, Shea LD, Green KJ The Journal of cell biology 26858265 J Cell Biol 2016 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/26858265
Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells. Decker JT, Hobson EC, Zhang Y, Shin S, Thomas AL, Jeruss JS, Arnold KB, Shea LD Biotechnology and bioengineering 28322442 Biotechnol Bioeng 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28322442
Retrievable hydrogels for ovarian follicle transplantation and oocyte collection. Rios PD, Kniazeva E, Lee HC, Xiao S, Oakes RS, Saito E, Jeruss JS, Shikanov A, Woodruff TK, Shea LD Biotechnology and bioengineering 29704433 Biotechnol Bioeng 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29704433
Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone. Roca H, Jones JD, Purica MC, Weidner S, Koh AJ, Kuo R, Wilkinson JE, Wang Y, Daignault-Newton S, Pienta KJ, Morgan TM, Keller ET, Nör JE, Shea LD, McCauley LK The Journal of clinical investigation 29202471 J Clin Invest 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29202471
Engineering the pre-metastatic niche. Aguado BA, Bushnell GG, Rao SS, Jeruss JS, Shea LD Nature biomedical engineering 28989814 Nat Biomed Eng 2017 https://www.ncbi.nlm.nih.gov/pubmed/28989814
Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury. Dumont CM, Margul DJ, Shea LD Cells, tissues, organs 27701152 Cells Tissues Organs 2016 https://www.ncbi.nlm.nih.gov/pubmed/27701152
Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography. Liu R, Song W, Backman V, Yi J Biomedical optics express 30800493 Biomed Opt Express 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30800493
Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging. Winkelmann JA, Eid A, Spicer G, Almassalha LM, Nguyen TQ, Backman V Light, science & applications 30651982 Light Sci Appl 2019 https://www.ncbi.nlm.nih.gov/pubmed/30651982
Secretome identification of immune cell factors mediating metastatic cell homing. Aguado BA, Wu JJ, Azarin SM, Nanavati D, Rao SS, Bushnell GG, Medicherla CB, Shea LD Scientific reports 26634905 Sci Rep 2015 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/26634905
Fractal Characterization of Chromatin Decompaction in Live Cells. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, Backman V Biophysical journal 26636933 Biophys J 2015 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/26636933
Dynamic microRNA activity identifies therapeutic targets in trastuzumab-resistant HER2(+) breast cancer. Decker JT, Hall MS, Blaisdell RB, Schwark K, Jeruss JS, Shea LD Biotechnology and bioengineering 29981261 Biotechnol Bioeng 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29981261
Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges. Margul DJ, Park J, Boehler RM, Smith DR, Johnson MA, McCreedy DA, He T, Ataliwala A, Kukushliev TV, Liang J, Sohrabi A, Goodman AG, Walthers CM, Shea LD, Seidlits SK Bioengineering & translational medicine 27981242 Bioeng Transl Med 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27981242
Theoretical model for optical oximetry at the capillary level: exploring hemoglobin oxygen saturation through backscattering of single red blood cells. Liu R, Spicer G, Chen S, Zhang HF, Yi J, Backman V Journal of biomedical optics 28157244 J Biomed Opt 2017 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/28157244
Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Rao SS, Bushnell GG, Azarin SM, Spicer G, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, Jeruss JS Cancer research 27635043 Cancer Res 2016 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/27635043
Cryotemplation for the Rapid Fabrication of Porous, Patternable Photopolymerized Hydrogels. Thomas AM, Shea LD Journal of materials chemistry. B 25083293 J Mater Chem B 2014 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/25083293
A PLG/HAp composite scaffold for lentivirus delivery. Boehler RM, Shin S, Fast AG, Gower RM, Shea LD Biomaterials 23602363 Biomaterials 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23602363
Heparin-chitosan nanoparticle functionalization of porous poly(ethylene glycol) hydrogels for localized lentivirus delivery of angiogenic factors. Thomas AM, Gomez AJ, Palma JL, Yap WT, Shea LD Biomaterials 25023395 Biomaterials 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25023395
Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression. Bushnell GG, Wicha MS, Jeruss JS, Shea LD Oncoscience 31984215 Oncoscience 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31984215
Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype. Boehler RM, Kuo R, Shin S, Goodman AG, Pilecki MA, Gower RM, Leonard JN, Shea LD Biotechnology and bioengineering 24375008 Biotechnol Bioeng 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24375008
Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, Shea LD Biomaterials 24309498 Biomaterials 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24309498
In vivo functional microangiography by visible-light optical coherence tomography. Yi J, Chen S, Backman V, Zhang HF Biomedical optics express 25360376 Biomed Opt Express 2014 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/25360376
In vivo capture and label-free detection of early metastatic cells. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD Nature communications 26348915 Nat Commun 2015 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/26348915
Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche. Aguado BA, Caffe JR, Nanavati D, Rao SS, Bushnell GG, Azarin SM, Shea LD Acta biomaterialia 26844426 Acta Biomater 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26844426
Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets. Liu JMH, Zhang J, Zhang X, Hlavaty KA, Ricci CF, Leonard JN, Shea LD, Gower RM Biomaterials 26701143 Biomaterials 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26701143
Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography. Liu R, Winkelmann JA, Spicer G, Zhu Y, Eid A, Ameer GA, Backman V, Yi J Light, science & applications 30839641 Light Sci Appl 2018 https://www.ncbi.nlm.nih.gov/pubmed/30839641
Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo. Bushnell GG, Rao SS, Hartfield RM, Zhang Y, Oakes RS, Jeruss JS, Shea LD Biotechnology and bioengineering 31544959 Biotechnol Bioeng 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31544959
High Frequency Spectral Ultrasound Imaging to Detect Metastasis in Implanted Biomaterial Scaffolds. Bushnell GG, Hong X, Hartfield RM, Zhang Y, Oakes RS, Rao SS, Jeruss JS, Stegemann JP, Deng CX, Shea LD Annals of biomedical engineering 31549327 Ann Biomed Eng 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31549327
Embryonic stem cell secreted factors decrease invasiveness of triple-negative breast cancer cells through regulome modulation. Tarasewicz E, Oakes RS, Aviles MO, Straehla J, Chilton KM, Decker JT, Wu J, Shea LD, Jeruss JS Cancer biology & therapy 29053396 Cancer Biol Ther 2018 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/29053396
Semiconductor quantum dots for bioimaging and biodiagnostic applications. Kairdolf BA, Smith AM, Stokes TH, Wang MD, Young AN, Nie S Annual review of analytical chemistry (Palo Alto, Calif.) 23527547 Annu Rev Anal Chem (Palo Alto Calif) 2013 https://www.ncbi.nlm.nih.gov/pubmed/23527547
Scale normalization of histopathological images for batch invariant cancer diagnostic models. Kothari S, Phan JH, Wang MD Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 23366904 Annu Int Conf IEEE Eng Med Biol Soc 2012 https://www.ncbi.nlm.nih.gov/pubmed/23366904
Feasibility of multiplex quantum dot stain using primary antibodies from four distinct host animals. Tran JK, Hubbard EN, Stokes TH, Moffitt RA, Wang MD Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 23367436 Annu Int Conf IEEE Eng Med Biol Soc 2012 https://www.ncbi.nlm.nih.gov/pubmed/23367436
Anchoring molecular chromophores to colloidal gold nanocrystals: surface-enhanced Raman evidence for strong electronic coupling and irreversible structural locking. Qian X, Emory SR, Nie S Journal of the American Chemical Society 22257217 J Am Chem Soc 2012 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/22257217
Predicting Heart Rejection Using Histopathological Whole-Slide Imaging and Deep Neural Network with Dropout. Tong L, Hoffman R, Deshpande SR, Wang MD ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics 32601619 IEEE EMBS Int Conf Biomed Health Inform 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/32601619
Deep learning based feature-level integration of multi-omics data for breast cancer patients survival analysis. Tong L, Mitchel J, Chatlin K, Wang MD BMC medical informatics and decision making 32933515 BMC Med Inform Decis Mak 2020 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/32933515
Impact of RNA-seq data analysis algorithms on gene expression estimation and downstream prediction. Tong L, Wu PY, Phan JH, Hassazadeh HR, SEQC Consortium, Tong W, Wang MD Scientific reports 33087762 Sci Rep 2020 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/33087762
Emerging technologies and their impact on regulatory science. Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle D, Tong L, Tong W, Eijnden-van-Raaij JVD, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W Jr Experimental biology and medicine (Maywood, N.J.) 34783606 Exp Biol Med (Maywood) 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34783606
Small portable interchangeable imager of fluorescence for fluorescence guided surgery and research. Okusanya OT, Madajewski B, Segal E, Judy BF, Venegas OG, Judy RP, Quatromoni JG, Wang MD, Nie S, Singhal S Technology in cancer research & treatment 24354756 Technol Cancer Res Treat 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/24354756
Targeted delivery of siRNA-generating DNA nanocassettes using multifunctional nanoparticles. Cho YS, Lee GY, Sajja HK, Qian W, Cao Z, He W, Karna P, Chen X, Mao H, Wang YA, Yang L Small (Weinheim an der Bergstrasse, Germany) 23292656 Small 2013 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/23292656
Pathology imaging informatics for quantitative analysis of whole-slide images. Kothari S, Phan JH, Stokes TH, Wang MD Journal of the American Medical Informatics Association : JAMIA 23959844 J Am Med Inform Assoc 2013 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/23959844
An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. Quatromoni JG, Singhal S, Bhojnagarwala P, Hancock WW, Albelda SM, Eruslanov E Journal of leukocyte biology 25359999 J Leukoc Biol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25359999
Molecular imaging to identify tumor recurrence following chemoradiation in a hostile surgical environment. Okusanya OT, Deshpande C, Barbosa EM Jr, Aggarwal C, Simone CB 2nd, Jiang J, Judy R, DeJesus E, Albelda S, Nie S, Low PS, Singhal S Molecular imaging 25442640 Mol Imaging 2014 https://www.ncbi.nlm.nih.gov/pubmed/25442640
CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer. Karakasheva TA, Waldron TJ, Eruslanov E, Kim SB, Lee JS, O'Brien S, Hicks PD, Basu D, Singhal S, Malavasi F, Rustgi AK Cancer research 26294209 Cancer Res 2015 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/26294209
Models for Predicting Stage in Head and Neck Squamous Cell Carcinoma Using Proteomic and Transcriptomic Data. Kaddi CD, Wang MD IEEE journal of biomedical and health informatics 26462248 IEEE J Biomed Health Inform 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/26462248
Effect of low-expression gene filtering on detection of differentially expressed genes in RNA-seq data. Sha Y, Phan JH, Wang MD Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 26737772 Annu Int Conf IEEE Eng Med Biol Soc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26737772
Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles. Wang X, Qian X, Beitler JJ, Chen ZG, Khuri FR, Lewis MM, Shin HJ, Nie S, Shin DM Cancer research 21212408 Cancer Res 2011 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/21212408
Combination of an Integrin-Targeting NIR Tracer and an Ultrasensitive Spectroscopic Device for Intraoperative Detection of Head and Neck Tumor Margins and Metastatic Lymph Nodes. Yoon Y, Mohs AM, Mancini MC, Nie S, Shim H Tomography (Ann Arbor, Mich.) 27738656 Tomography 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27738656
Bioconjugated Nanoparticles for Biosensing, in Vivo Imaging, and Medical Diagnostics. Kairdolf BA, Qian X, Nie S Analytical chemistry 28043119 Anal Chem 2017 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/28043119
Near-Infrared Intraoperative Molecular Imaging Can Locate Metastases to the Lung. Keating J, Newton A, Venegas O, Nims S, Zeh R, Predina J, Deshpande C, Kucharczuk J, Nie S, Delikatny EJ, Singhal S The Annals of thoracic surgery 27793401 Ann Thorac Surg 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27793401
Integrating multi-omics data by learning modality invariant representations for improved prediction of overall survival of cancer. Tong L, Wu H, Wang MD Methods (San Diego, Calif.) 32763377 Methods 2021 May https://www.ncbi.nlm.nih.gov/pubmed/32763377
Prediction of Heart Transplant Rejection Using Histopathological Whole-Slide Imaging. Dooley AE, Tong L, Deshpande SR, Wang MD ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics 32551442 IEEE EMBS Int Conf Biomed Health Inform 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/32551442
CAESNet: Convolutional AutoEncoder based Semi-supervised Network for improving multiclass classification of endomicroscopic images. Tong L, Wu H, Wang MD Journal of the American Medical Informatics Association : JAMIA 31260038 J Am Med Inform Assoc 2019 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/31260038
Metabolic characterization of a Sirt5 deficient mouse model. Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J Scientific reports 24076663 Sci Rep 2013 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/24076663
Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images. Li M, Jirapatnakul A, Biancardi A, Riccio ML, Weiss RS, Reeves AP PloS one 24376755 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24376755
Sirtuin inhibitors as anticancer agents. Hu J, Jing H, Lin H Future medicinal chemistry 24962284 Future Med Chem 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24962284
Protein lysine acylation and cysteine succination by intermediates of energy metabolism. Lin H, Su X, He B ACS chemical biology 22571489 ACS Chem Biol 2012 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/22571489
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy. Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA Nature communications 27089238 Nat Commun 2016 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/27089238
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H Cancer cell 26977881 Cancer Cell 2016 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/26977881
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). Zhou Y, Zhang H, He B, Du J, Lin H, Cerione RA, Hao Q The Journal of biological chemistry 22767592 J Biol Chem 2012 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/22767592
Matrix stiffening promotes a tumor vasculature phenotype. Bordeleau F, Mason BN, Lollis EM, Mazzola M, Zanotelli MR, Somasegar S, Califano JP, Montague C, LaValley DJ, Huynh J, Mencia-Trinchant N, Negrón Abril YL, Hassane DC, Bonassar LJ, Butcher JT, Weiss RS, Reinhart-King CA Proceedings of the National Academy of Sciences of the United States of America 28034921 Proc Natl Acad Sci U S A 2017 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/28034921
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Stalnecker CA, Ulrich SM, Li Y, Ramachandran S, McBrayer MK, DeBerardinis RJ, Cerione RA, Erickson JW Proceedings of the National Academy of Sciences of the United States of America 25548170 Proc Natl Acad Sci U S A 2015 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/25548170
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS Oncogene 33479498 Oncogene 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33479498
Assessment of SIRT2 Inhibitors in Mouse Models of Cancer. Negrón Abril YL, Fernández I, Weiss RS Methods in molecular biology (Clifton, N.J.) 31087297 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31087297
Therapeutic strategies impacting cancer cell glutamine metabolism. Lukey MJ, Wilson KF, Cerione RA Future medicinal chemistry 24047273 Future Med Chem 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/24047273
Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors. Bordeleau F, Califano JP, Negrón Abril YL, Mason BN, LaValley DJ, Shin SJ, Weiss RS, Reinhart-King CA Proceedings of the National Academy of Sciences of the United States of America 26106154 Proc Natl Acad Sci U S A 2015 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/26106154
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H Proceedings of the National Academy of Sciences of the United States of America 27051063 Proc Natl Acad Sci U S A 2016 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/27051063
Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS. Li Y, Erickson JW, Stalnecker CA, Katt WP, Huang Q, Cerione RA, Ramachandran S The Journal of biological chemistry 27542409 J Biol Chem 2016 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/27542409
Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model. Li C, Chacko AM, Hu J, Hasegawa K, Swails J, Grasso L, El-Deiry WS, Nicolaides N, Muzykantov VR, Divgi CR, Coukos G Cancer biology & therapy 24553243 Cancer Biol Ther 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24553243
T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression. Santoro SP, Kim S, Motz GT, Alatzoglou D, Li C, Irving M, Powell DJ Jr, Coukos G Cancer immunology research 25358763 Cancer Immunol Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25358763
Correction to: Characterization of the first fully human anti-TEM1 scFv in models of solid tumor imaging and immunotoxin-based therapy. Yuan X, Yang M, Chen X, Zhang X, Sukhadia S, Musolino N, Bao H, Chen T, Xu C, Wang Q, Santoro S, Ricklin D, Hu J, Lin R, Yang W, Li Z, Qin W, Zhao A, Scholler N, Coukos G Cancer immunology, immunotherapy : CII 29313073 Cancer Immunol Immunother 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29313073
Targeting the tumor vasculature to enhance T cell activity. Lanitis E, Irving M, Coukos G Current opinion in immunology 25665467 Curr Opin Immunol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25665467
Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors. Homicsko K, Duraiswamy J, Doucey MA, Coukos G Cancer research 27909064 Cancer Res 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27909064
A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development. Hu J, Chen X, Zhang X, Yuan X, Yang M, Dai H, Yang W, Zhou Q, Wen W, Wang Q, Qin W, Zhao A Protein science : a publication of the Protein Society 29500915 Protein Sci 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29500915
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Motz GT, Santoro SP, Wang LP, Garrabrant T, Lastra RR, Hagemann IS, Lal P, Feldman MD, Benencia F, Coukos G Nature medicine 24793239 Nat Med 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24793239
T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy. Melero I, Rouzaut A, Motz GT, Coukos G Cancer discovery 24795012 Cancer Discov 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24795012
Mass spectrometry-based antigen discovery for cancer immunotherapy. Bassani-Sternberg M, Coukos G Current opinion in immunology 27155075 Curr Opin Immunol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27155075
Interrogating open issues in cancer precision medicine with patient-derived xenografts. Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinská E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, Mælandsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D, Villanueva A, Vinolo E, Bertotti A, Trusolino L Nature reviews. Cancer 28104906 Nat Rev Cancer 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28104906
Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer. Li C, Wang J, Hu J, Feng Y, Hasegawa K, Peng X, Duan X, Zhao A, Mikitsh JL, Muzykantov VR, Chacko AM, Pryma DA, Dunn SM, Coukos G Oncotarget 25051365 Oncotarget 2014 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/25051365
Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer. Matthaiou EI, Barar J, Sandaltzopoulos R, Li C, Coukos G, Omidi Y International journal of nanomedicine 24790428 Int J Nanomedicine 2014 https://www.ncbi.nlm.nih.gov/pubmed/24790428
Development of 124I immuno-PET targeting tumor vascular TEM1/endosialin. Chacko AM, Li C, Nayak M, Mikitsh JL, Hu J, Hou C, Grasso L, Nicolaides NC, Muzykantov VR, Divgi CR, Coukos G Journal of nuclear medicine : official publication, Society of Nuclear Medicine 24525208 J Nucl Med 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24525208
Deciphering and reversing tumor immune suppression. Motz GT, Coukos G Immunity 23890064 Immunity 2013 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/23890064
Targeting the undruggable: immunotherapy meets personalized oncology in the genomic era. Martin SD, Coukos G, Holt RA, Nelson BH Annals of oncology : official journal of the European Society for Medical Oncology 26371284 Ann Oncol 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26371284
Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma. Guo Y, Hu J, Wang Y, Peng X, Min J, Wang J, Matthaiou E, Cheng Y, Sun K, Tong X, Fan Y, Zhang PJ, Kandalaft LE, Irving M, Coukos G, Li C European journal of cancer (Oxford, England : 1990) 29304474 Eur J Cancer 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29304474
BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor-Mediated Calcium Signaling. Pyfrom SC, Quinn CC, Dorando HK, Luo H, Payton JE Journal of immunology (Baltimore, Md. : 1950) 32571842 J Immunol 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32571842
PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities. Pyfrom SC, Luo H, Payton JE BMC genomics 30767760 BMC Genomics 2019 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/30767760
Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus. Guo C, Gerasimova T, Hao H, Ivanova I, Chakraborty T, Selimyan R, Oltz EM, Sen R Cell 21982154 Cell 2011 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/21982154
Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome. Gu J, Stevens M, Xing X, Li D, Zhang B, Payton JE, Oltz EM, Jarvis JN, Jiang K, Cicero T, Costello JF, Wang T G3 (Bethesda, Md.) 26888867 G3 (Bethesda) 2016 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/26888867
Targeted epigenetic repression of a lymphoma oncogene by sequence-specific histone modifiers induces apoptosis in DLBCL. Luo H, Schmidt JA, Lee YS, Oltz EM, Payton JE Leukemia & lymphoma 27268204 Leuk Lymphoma 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27268204
NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo. Raju S, Kretzmer LZ, Koues OI, Payton JE, Oltz EM, Cashen A, Polic B, Schreiber RD, Shaw AS, Markiewicz MA Journal of immunology (Baltimore, Md. : 1950) 27183590 J Immunol 2016 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/27183590
cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent. Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, Oltz EM Cell reports 28329684 Cell Rep 2017 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/28329684
Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma. Koues OI, Kowalewski RA, Chang LW, Pyfrom SC, Schmidt JA, Luo H, Sandoval LE, Hughes TB, Bednarski JJ, Cashen AF, Payton JE, Oltz EM Immunity 25607463 Immunity 2015 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/25607463
Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers. Andrews JM, Pyfrom SC, Schmidt JA, Koues OI, Kowalewski RA, Grams NR, Sun JJ, Berman LR, Duncavage EJ, Lee YS, Cashen AF, Oltz EM, Payton JE EBioMedicine 34461601 EBioMedicine 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34461601
Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci. Predeus AV, Gopalakrishnan S, Huang Y, Tang J, Feeney AJ, Oltz EM, Artyomov MN Journal of immunology (Baltimore, Md. : 1950) 24353267 J Immunol 2014 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/24353267
Unifying model for molecular determinants of the preselection Vβ repertoire. Gopalakrishnan S, Majumder K, Predeus A, Huang Y, Koues OI, Verma-Gaur J, Loguercio S, Su AI, Feeney AJ, Artyomov MN, Oltz EM Proceedings of the National Academy of Sciences of the United States of America 23918392 Proc Natl Acad Sci U S A 2013 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/23918392
Short-Circuiting Gene Regulatory Networks: Origins of B Cell Lymphoma. Koues OI, Oltz EM, Payton JE Trends in genetics : TIG 26604030 Trends Genet 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26604030
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies. Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S Nature communications 30664659 Nat Commun 2019 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/30664659
Humanized hemato-lymphoid system mice. Theocharides AP, Rongvaux A, Fritsch K, Flavell RA, Manz MG Haematologica 26721800 Haematologica 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26721800
Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation. Nair S, Boddupalli CS, Verma R, Liu J, Yang R, Pastores GM, Mistry PK, Dhodapkar MV Blood 25499455 Blood 2015 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/25499455
Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice. Das R, Strowig T, Verma R, Koduru S, Hafemann A, Hopf S, Kocoglu MH, Borsotti C, Zhang L, Branagan A, Eynon E, Manz MG, Flavell RA, Dhodapkar MV Nature medicine 27723723 Nat Med 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27723723
Peripheral blood CD34(+) cells efficiently engraft human cytokine knock-in mice. Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG Blood 27543436 Blood 2016 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/27543436
A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production. Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA Blood 28077418 Blood 2017 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/28077418
BRAFV 600E or mutant MAP2K1 human CD34+ cells establish Langerhans cell-like histiocytosis in immune-deficient mice. Rafiei A, Wilk CM, Helbling PM, Myburgh R, Saito Y, Haralambieva E, Soldini D, Chakraborty R, Merad M, Allen CE, Nombela-Arrieta C, Manz MG Blood advances 33035332 Blood Adv 2020 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/33035332
Targeting human dendritic cells in situ to improve vaccines. Sehgal K, Dhodapkar KM, Dhodapkar MV Immunology letters 25072116 Immunol Lett 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25072116
Development and function of human innate immune cells in a humanized mouse model. Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA Nature biotechnology 24633240 Nat Biotechnol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24633240
Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. Sehgal K, Ragheb R, Fahmy TM, Dhodapkar MV, Dhodapkar KM Journal of immunology (Baltimore, Md. : 1950) 25080481 J Immunol 2014 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/25080481
Human hemato-lymphoid system mice: current use and future potential for medicine. Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG Annual review of immunology 23330956 Annu Rev Immunol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23330956
Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma. Nair S, Branagan AR, Liu J, Boddupalli CS, Mistry PK, Dhodapkar MV The New England journal of medicine 26863356 N Engl J Med 2016 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/26863356
inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice. Ellegast JM, Rauch PJ, Kovtonyuk LV, Müller R, Wagner U, Saito Y, Wildner-Verhey van Wijk N, Fritz C, Rafiei A, Lysenko V, Dudkiewicz E, Theocharides AP, Soldini D, Goede JS, Flavell RA, Manz MG Blood 27581357 Blood 2016 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/27581357
The Ability of Narrative Communication to Address Health-related Social Norms. Moran MB, Murphy ST, Frank L, Baezconde-Garbanati L International Review of Social Research 24179677 Int Rev Soc Res 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/24179677
Reducing the Excess Burden of Cervical Cancer Among Latinas: Translating Science into Health Promotion Initiatives. Baezconde-Garbanati L, Murphy ST, Moran MB, Cortessis VK Californian journal of health promotion 24587769 Calif J Health Promot 2013 https://www.ncbi.nlm.nih.gov/pubmed/24587769
Narrative versus Non-narrative: The Role of Identification, Transportation and Emotion in Reducing Health Disparities. Murphy ST, Frank LB, Chatterjee JS, Baezconde-Garbanati L The Journal of communication 24347679 J Commun 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/24347679
Self-Construal as a Predictor of Korean American Women's Intention to Vaccinate Daughters against Human Papillomavirus. Zhao N, Huh J, Murphy ST, Chatterjee JS, Baezconde-Garbanati L Asian American journal of psychology 25558309 Asian Am J Psychol 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/25558309
Barriers and innovative interventions for early detection of cervical cancer. Baezconde-Garbanati L, Agurto I, Gravitt PE, Luciani S, Murphy S, Ochoa C, Gallegos K, Barahona R, Rodríguez Y Salud publica de Mexico 31430087 Salud Publica Mex 2019 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/31430087
Implementation of HPV vaccination guidelines in a diverse population in Los Angeles: Results from an environmental scan of local HPV resources and needs. Baezconde-Garbanati L, Lienemann BA, Robles M, Johnson E, Sanchez K, Singhal R, Steinberg J, Jaque JM, Pentz MA, Gruber S Vaccine 28774559 Vaccine 2017 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/28774559
A pilot test of the acceptability and efficacy of narrative and non-narrative health education materials in a low health literacy population. Moran MB, Frank LB, Chatterjee JS, Murphy ST, Baezconde-Garbanati L Journal of communication in healthcare 27872657 J Commun Healthc 2016 https://www.ncbi.nlm.nih.gov/pubmed/27872657
Information scanning and vaccine safety concerns among African American, Mexican American, and non-Hispanic White women. Moran MB, Frank LB, Chatterjee JS, Murphy ST, Baezconde-Garbanati L Patient education and counseling 26321294 Patient Educ Couns 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26321294
Public Diplomacy in Prime Time: Exploring the Potential of Entertainment Education in International Public Diplomacy. Murphy ST, Hether HJ, Felt LJ, de Castro Buffington S American journal of media psychology 24489980 Am J Media Psychol 2012 https://www.ncbi.nlm.nih.gov/pubmed/24489980
Portrayals of reproductive and sexual health on prime-time television. Pariera KL, Hether HJ, Murphy ST, Buffington Sde C, Baezconde-Garbanati L Health communication 24156468 Health Commun 2014 https://www.ncbi.nlm.nih.gov/pubmed/24156468
Each Medium Tells a Different Story: The Effect of Message Channel on Narrative Persuasion. Walter N, Murphy ST, Frank LB, Baezconde-Garbanati L Communication research reports : CRR 30739986 Commun Res Rep 2017 https://www.ncbi.nlm.nih.gov/pubmed/30739986
Assessing impact of a community-based screening campaign to address social determinants of cervical cancer. Po J, Bookstein A, Lee W, Barahona R, Baezconde-Garbanati L JNCI cancer spectrum 39888858 JNCI Cancer Spectr 2025 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/39888858
Comparing the Relative Efficacy of Narrative vs Nonnarrative Health Messages in Reducing Health Disparities Using a Randomized Trial. Murphy ST, Frank LB, Chatterjee JS, Moran MB, Zhao N, Amezola de Herrera P, Baezconde-Garbanati LA American journal of public health 25905845 Am J Public Health 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25905845
Telling stories, saving lives: creating narrative health messages. Frank LB, Murphy ST, Chatterjee JS, Moran MB, Baezconde-Garbanati L Health communication 25470440 Health Commun 2015 https://www.ncbi.nlm.nih.gov/pubmed/25470440
Using a Culturally Tailored Narrative to Increase Cervical Cancer Detection Among Spanish-Speaking Mexican-American Women. Ochoa CY, Murphy ST, Frank LB, Baezconde-Garbanati LA Journal of cancer education : the official journal of the American Association for Cancer Education 31020621 J Cancer Educ 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/31020621
The strategy, organization, and progress of the HUPO Human Proteome Project. Omenn GS Journal of proteomics 24145142 J Proteomics 2014 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/24145142
Distinct splice variants and pathway enrichment in the cell-line models of aggressive human breast cancer subtypes. Menon R, Im H, Zhang EY, Wu SL, Chen R, Snyder M, Hancock WS, Omenn GS Journal of proteome research 24111759 J Proteome Res 2014 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/24111759
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. Gonzalez-Hernandez MJ, Swanson MD, Contreras-Galindo R, Cookinham S, King SR, Noel RJ Jr, Kaplan MH, Markovitz DM Journal of virology 22593154 J Virol 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22593154
Human endogenous retrovirus K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1. Monde K, Contreras-Galindo R, Kaplan MH, Markovitz DM, Ono A Journal of virology 22855497 J Virol 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22855497
Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. Contreras-Galindo R, Kaplan MH, Contreras-Galindo AC, Gonzalez-Hernandez MJ, Ferlenghi I, Giusti F, Lorenzo E, Gitlin SD, Dosik MH, Yamamura Y, Markovitz DM Journal of virology 22031938 J Virol 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22031938
Rapid molecular assays to study human centromere genomics. Contreras-Galindo R, Fischer S, Saha AK, Lundy JD, Cervantes PW, Mourad M, Wang C, Qian B, Dai M, Meng F, Chinnaiyan A, Omenn GS, Kaplan MH, Markovitz DM Genome research 29141960 Genome Res 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29141960
NGSQC: cross-platform quality analysis pipeline for deep sequencing data. Dai M, Thompson RC, Maher C, Contreras-Galindo R, Kaplan MH, Markovitz DM, Omenn G, Meng F BMC genomics 21143816 BMC Genomics 2010 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/21143816
Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans. Zahn J, Kaplan MH, Fischer S, Dai M, Meng F, Saha AK, Cervantes P, Chan SM, Dube D, Omenn GS, Markovitz DM, Contreras-Galindo R Genome biology 25886262 Genome Biol 2015 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/25886262
Innovations in proteomic profiling of cancers: alternative splice variants as a new class of cancer biomarker candidates and bridging of proteomics with structural biology. Omenn GS, Menon R, Zhang Y Journal of proteomics 23603631 J Proteomics 2013 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/23603631
Regulation of the human endogenous retrovirus K (HML-2) transcriptome by the HIV-1 Tat protein. Gonzalez-Hernandez MJ, Cavalcoli JD, Sartor MA, Contreras-Galindo R, Meng F, Dai M, Dube D, Saha AK, Gitlin SD, Omenn GS, Kaplan MH, Markovitz DM Journal of virology 24872592 J Virol 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24872592
HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses. Contreras-Galindo R, Kaplan MH, He S, Contreras-Galindo AC, Gonzalez-Hernandez MJ, Kappes F, Dube D, Chan SM, Robinson D, Meng F, Dai M, Gitlin SD, Chinnaiyan AM, Omenn GS, Markovitz DM Genome research 23657884 Genome Res 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23657884
Genomic flexibility of human endogenous retrovirus type K. Dube D, Contreras-Galindo R, He S, King SR, Gonzalez-Hernandez MJ, Gitlin SD, Kaplan MH, Markovitz DM Journal of virology 24920813 J Virol 2014 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/24920813
Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors. Contreras-Galindo R, Dube D, Fujinaga K, Kaplan MH, Markovitz DM Journal of virology 28931682 J Virol 2017 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/28931682
Metrics for the Human Proteome Project 2013-2014 and strategies for finding missing proteins. Lane L, Bairoch A, Beavis RC, Deutsch EW, Gaudet P, Lundberg E, Omenn GS Journal of proteome research 24364385 J Proteome Res 2014 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/24364385
A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines. Omenn GS, Guan Y, Menon R Journal of proteomics 24802673 J Proteomics 2014 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/24802673
"Reverse genomics" and human endogenous retroviruses. Markovitz DM Transactions of the American Clinical and Climatological Association 25125718 Trans Am Clin Climatol Assoc 2014 https://www.ncbi.nlm.nih.gov/pubmed/25125718
Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences. Contreras-Galindo R, Kaplan MH, Dube D, Gonzalez-Hernandez MJ, Chan S, Meng F, Dai M, Omenn GS, Gitlin SD, Markovitz DM Journal of virology 25926654 J Virol 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25926654
Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity. Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM Cell 26496612 Cell 2015 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/26496612
Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Stelzer AC, Frank AT, Kratz JD, Swanson MD, Gonzalez-Hernandez MJ, Lee J, Andricioaei I, Markovitz DM, Al-Hashimi HM Nature chemical biology 21706033 Nat Chem Biol 2011 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/21706033
Strategies for Genomic and Proteomic Profiling of Cancers. Omenn GS Statistics in biosciences 27594925 Stat Biosci 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27594925
The Genomic Landscape of Centromeres in Cancers. Saha AK, Mourad M, Kaplan MH, Chefetz I, Malek SN, Buckanovich R, Markovitz DM, Contreras-Galindo R Scientific reports 31375789 Sci Rep 2019 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/31375789
Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium. Toth R, Scherer D, Kelemen LE, Risch A, Hazra A, Balavarca Y, Issa JJ, Moreno V, Eeles RA, Ogino S, Wu X, Ye Y, Hung RJ, Goode EL, Ulrich CM, OCAC, CORECT, TRICL, ELLIPSE, DRIVE, and GAME-ON consortia Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 28115406 Cancer Epidemiol Biomarkers Prev 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28115406
A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis. Markowitz SD, Nock NL, Schmit SL, Stadler ZK, Joseph V, Zhang L, Willis JE, Scacheri P, Veigl M, Adams MD, Raskin L, Sullivan JF, Stratton K, Shia J, Ellis N, Rennert HS, Manschreck C, Li L, Offit K, Elston RC, Rennert G, Gruber SB PloS one 26751797 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/26751797
Shared heritability and functional enrichment across six solid cancers. Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeböller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton JD, Brook MN, Brunet J, Brunnström H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldés T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Campa D, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collée JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dörk T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Edwards DRV, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, García-Sáenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guénel P, Håkansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Høgdall E, Hong YC, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jakubowska A, James P, Jenkins MA, Johansson M, Johansson M, John EM, Joshi AD, Kaneva R, Karlan BY, Kelemen LE, Kühl T, Khaw KT, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz HJ, Leslie G, Lessel D, Lester J, Levine DA, Li L, Li CI, Lindblom A, Lindor NM, Liu G, Loupakis F, Lubiński J, Maehle L, Maier C, Mannermaa A, Marchand LL, Margolin S, May T, McGuffog L, Meindl A, Middha P, Miller A, Milne RL, MacInnis RJ, Modugno F, Montagna M, Moreno V, Moysich KB, Mucci L, Muir K, Mulligan AM, Nathanson KL, Neal DE, Ness AR, Neuhausen SL, Nevanlinna H, Newcomb PA, Newcomb LF, Nielsen FC, Nikitina-Zake L, Nordestgaard BG, Nussbaum RL, Offit K, Olah E, Olama AAA, Olopade OI, Olshan AF, Olsson H, Osorio A, Pandha H, Park JY, Pashayan N, Parsons MT, Pejovic T, Penney KL, Peters WHM, Phelan CM, Phipps AI, Plaseska-Karanfilska D, Pring M, Prokofyeva D, Radice P, Stefansson K, Ramus SJ, Raskin L, Rennert G, Rennert HS, van Rensburg EJ, Riggan MJ, Risch HA, Risch A, Roobol MJ, Rosenstein BS, Rossing MA, De Ruyck K, Saloustros E, Sandler DP, Sawyer EJ, Schabath MB, Schleutker J, Schmidt MK, Setiawan VW, Shen H, Siegel EM, Sieh W, Singer CF, Slattery ML, Sorensen KD, Southey MC, Spurdle AB, Stanford JL, Stevens VL, Stintzing S, Stone J, Sundfeldt K, Sutphen R, Swerdlow AJ, Tajara EH, Tangen CM, Tardon A, Taylor JA, Teare MD, Teixeira MR, Terry MB, Terry KL, Thibodeau SN, Thomassen M, Bjørge L, Tischkowitz M, Toland AE, Torres D, Townsend PA, Travis RC, Tung N, Tworoger SS, Ulrich CM, Usmani N, Vachon CM, Van Nieuwenhuysen E, Vega A, Aguado-Barrera ME, Wang Q, Webb PM, Weinberg CR, Weinstein S, Weissler MC, Weitzel JN, West CML, White E, Whittemore AS, Wichmann HE, Wiklund F, Winqvist R, Wolk A, Woll P, Woods M, Wu AH, Wu X, Yannoukakos D, Zheng W, Zienolddiny S, Ziogas A, Zorn KK, Lane JM, Saxena R, Thomas D, Hung RJ, Diergaarde B, McKay J, Peters U, Hsu L, García-Closas M, Eeles RA, Chenevix-Trench G, Brennan PJ, Haiman CA, Simard J, Easton DF, Gruber SB, Pharoah PDP, Price AL, Pasaniuc B, Amos CI, Kraft P, Lindström S Nature communications 30683880 Nat Commun 2019 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/30683880
Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects. Guo X, Lin W, Wen W, Huyghe J, Bien S, Cai Q, Harrison T, Chen Z, Qu C, Bao J, Long J, Yuan Y, Wang F, Bai M, Abecasis GR, Albanes D, Berndt SI, Bézieau S, Bishop DT, Brenner H, Buch S, Burnett-Hartman A, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Cho SH, Conti DV, Chapelle A, Feskens EJM, Gallinger SJ, Giles GG, Goodman PJ, Gsur A, Guinter M, Gunter MJ, Hampe J, Hampel H, Hayes RB, Hoffmeister M, Kampman E, Kang HM, Keku TO, Kim HR, Le Marchand L, Lee SC, Li CI, Li L, Lindblom A, Lindor N, Milne RL, Moreno V, Murphy N, Newcomb PA, Nickerson DA, Offit K, Pearlman R, Pharoah PDP, Platz EA, Potter JD, Rennert G, Sakoda LC, Schafmayer C, Schmit SL, Schoen RE, Schumacher FR, Slattery ML, Su YR, Tangen CM, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Wang X, White E, Wolk A, Woods MO, Casey G, Hsu L, Jenkins MA, Gruber SB, Peters U, Zheng W Gastroenterology 33058866 Gastroenterology 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33058866
Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang-Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago-Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, Greenson JK, Gsur A, Gunter M, Haiman CA, Hampe J, Harlid S, Harju JF, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Huang SC, Huerta JM, Hudson TJ, Hunter DJ, Idos GE, Iwasaki M, Jackson RD, Jacobs EJ, Jee SH, Jenkins MA, Jia WH, Jiao S, Joshi AD, Kolonel LN, Kono S, Kooperberg C, Krogh V, Kuehn T, Küry S, LaCroix A, Laurie CA, Lejbkowicz F, Lemire M, Lenz HJ, Levine D, Li CI, Li L, Lieb W, Lin Y, Lindor NM, Liu YR, Loupakis F, Lu Y, Luh F, Ma J, Mancao C, Manion FJ, Markowitz SD, Martin V, Matsuda K, Matsuo K, McDonnell KJ, McNeil CE, Milne R, Molina AJ, Mukherjee B, Murphy N, Newcomb PA, Offit K, Omichessan H, Palli D, Cotoré JPP, Pérez-Mayoral J, Pharoah PD, Potter JD, Qu C, Raskin L, Rennert G, Rennert HS, Riggs BM, Schafmayer C, Schoen RE, Sellers TA, Seminara D, Severi G, Shi W, Shibata D, Shu XO, Siegel EM, Slattery ML, Southey M, Stadler ZK, Stern MC, Stintzing S, Taverna D, Thibodeau SN, Thomas DC, Trichopoulou A, Tsugane S, Ulrich CM, van Duijnhoven FJB, van Guelpan B, Vijai J, Virtamo J, Weinstein SJ, White E, Win AK, Wolk A, Woods M, Wu AH, Wu K, Xiang YB, Yen Y, Zanke BW, Zeng YX, Zhang B, Zubair N, Kweon SS, Figueiredo JC, Zheng W, Marchand LL, Lindblom A, Moreno V, Peters U, Casey G, Hsu L, Conti DV, Gruber SB Journal of the National Cancer Institute 29917119 J Natl Cancer Inst 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/29917119
Nonadditive Effects of Common Genetic Variants Have a Negligent Contribution to Cancer Heritability. Hammermeister Suger A, Harrison TA, Henning B, Turman C, Kraft P, Lindström S Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 39018351 Cancer Epidemiol Biomarkers Prev 2024 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/39018351
IgG-seq identifies immune-reactive enteric bacteria in Crohn's disease with spondyloarthritis. Maldarelli GA, Metz M, Oguntunmibi S, Tran N, Xiang G, Lukin D, Scherl EJ, Longman RS Gut microbes 39949039 Gut Microbes 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/39949039
Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity. Jin WB, Xiao L, Jeong M, Han SJ, Zhang W, Yano H, Shi H, Arifuzzaman M, Lyu M, Wang D, Tang YA, Qiao S, JRI IBD Live Cell Bank Consortium, Yang X, Yang HS, Fu J, Sonnenberg GF, Collins N, Artis D, Guo CJ Cell 40239649 Cell 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/40239649
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities. Iliev ID, Ananthakrishnan AN, Guo CJ Nature reviews. Microbiology 40065181 Nat Rev Microbiol 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40065181
Precision microbiota therapy for IBD: premise and promise. Nagayama M, Gogokhia L, Longman RS Gut microbes 40190259 Gut Microbes 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/40190259
Microbiota-mediated mechanisms of mucosal immunity across the lifespan. Iliev ID, Blander JM, Collins N, Guo CJ, Longman RS, Sonnenberg GF, Zeng MY, Artis D Nature immunology 40957908 Nat Immunol 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40957908
Integrative detection of genome-wide translation using iRibo. Turcan A, Lee J, Wacholder A, Carvunis AR STAR protocols 38217852 STAR Protoc 2024 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/38217852
Sliding Window INteraction Grammar (SWING): a generalized interaction language model for peptide and protein interactions. Omelchenko AA, Siwek JC, Chhibbar P, Arshad S, Nazarali I, Nazarali K, Rosengart A, Rahimikollu J, Tilstra J, Shlomchik MJ, Koes DR, Joglekar AV, Das J bioRxiv : the preprint server for biology 38746274 bioRxiv 2024 May 4 https://www.ncbi.nlm.nih.gov/pubmed/38746274
GitHub is an effective platform for collaborative and reproducible laboratory research. Chen KY, Toro-Moreno M, Subramaniam AR ArXiv 39990799 ArXiv 2025 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/39990799
GitHub enables collaborative and reproducible laboratory research. Chen KY, Toro-Moreno M, Subramaniam AR PLoS biology 39951468 PLoS Biol 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39951468
Emergence and Tandem Repeat-Mediated Elongation of a Translated De Novo Open Reading Frame in Human Oncogenic RNA Gene VPS9D1-AS1 (MYU). Chou L, Cho ST, Lee J, Laub D, Meyer D, Carter H, Carvunis AR Genome biology and evolution 41527363 Genome Biol Evol 2026 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/41527363
High-quality peptide evidence for annotating non-canonical open reading frames as human proteins. Deutsch EW, Kok LW, Mudge JM, Ruiz-Orera J, Fierro-Monti I, Sun Z, Abelin JG, Alba MM, Aspden JL, Bazzini AA, Bruford EA, Brunet MA, Calviello L, Carr SA, Carvunis AR, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Hubner N, Ingolia NT, Magrane M, Martin MJ, Martinez TF, Menschaert G, Ohler U, Orchard S, Rackham O, Roucou X, Slavoff SA, Valen E, Wacholder A, Weissman JS, Wu W, Xie Z, Choudhary J, Bassani-Sternberg M, Vizcaíno JA, Ternette N, Moritz RL, Prensner JR, van Heesch S bioRxiv : the preprint server for biology 39314370 bioRxiv 2025 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/39314370
Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets. Arshad S, Cameron B, Joglekar AV NPJ systems biology and applications 39833247 NPJ Syst Biol Appl 2025 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/39833247
Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment. Wacholder A, Deutsch EW, Kok LW, van Dinter JT, Lee J, Wright JC, Leblanc S, Jayatissa AH, Jiang K, Arefiev I, Cao K, Bourassa F, Trifiro FA, Bassani-Sternberg M, Baranov PV, Bogaert A, Chothani S, Fierro-Monti I, Fijalkowska D, Gevaert K, Hubner N, Mudge JM, Ruiz-Orera J, Schulz J, Vizcaíno JA, Prensner JR, Brunet MA, Martinez TF, Slavoff SA, Roucou X, Choudhary JS, van Heesch S, Moritz RL, Carvunis AR bioRxiv : the preprint server for biology 40027765 bioRxiv 2025 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/40027765
Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions. Siwek JC, Omelchenko AA, Chhibbar P, Arshad S, Rosengart A, Nazarali I, Patel A, Nazarali K, Rahimikollu J, Tilstra JS, Shlomchik MJ, Koes DR, Joglekar AV, Das J Nature methods 40721872 Nat Methods 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40721872
Pseudomonas aeruginosa modulates both Caenorhabditis elegans attraction and pathogenesis by regulating nitrogen assimilation. Marogi JG, Murphy CT, Myhrvold C, Gitai Z Nature communications 39256376 Nat Commun 2024 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/39256376
A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance. Sengupta T, St Ange J, Moore R, Kaletsky R, Marogi J, Myhrvold C, Gitai Z, Murphy CT bioRxiv : the preprint server for biology 37503135 bioRxiv 2023 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/37503135
CeLab, a microfluidic platform for the study of life history traits, reveals metformin and SGK-1 regulation of longevity and reproductive span. Sohrabi S, Cota V, Murphy CT Lab on a chip 37221962 Lab Chip 2023 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/37221962
A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance. Sengupta T, St Ange J, Kaletsky R, Moore RS, Seto RJ, Marogi J, Myhrvold C, Gitai Z, Murphy CT PLoS genetics 38547071 PLoS Genet 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38547071
C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1. Seto RJ, Brown R, Kaletsky R, Parsons LR, Moore RS, Balch JM, Gitai Z, Murphy CT Science advances 40267186 Sci Adv 2025 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/40267186
Single-cell massively-parallel multiplexed microbial sequencing (M3-seq) identifies rare bacterial populations and profiles phage infection. Wang B, Lin AE, Yuan J, Novak KE, Koch MD, Wingreen NS, Adamson B, Gitai Z Nature microbiology 37653008 Nat Microbiol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37653008
Pseudomonas fluorescens 15 small RNA Pfs1 mediates transgenerational epigenetic inheritance of pathogen avoidance in C. elegans through the Ephrin receptor VAB-1. Seto R, Brown R, Kaletsky R, Parsons LR, Moore RS, Murphy CT bioRxiv : the preprint server for biology 38826453 bioRxiv 2024 May 23 https://www.ncbi.nlm.nih.gov/pubmed/38826453
P. aeruginosa controls both C. elegans attraction and pathogenesis by regulating nitrogen assimilation. Marogi JG, Murphy CT, Myhrvold C, Gitai Z bioRxiv : the preprint server for biology 38077073 bioRxiv 2023 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/38077073
A microRNA expression and regulatory element activity atlas of the mouse immune system. Rose SA, Wroblewska A, Dhainaut M, Yoshida H, Shaffer JM, Bektesevic A, Ben-Zvi B, Rhoads A, Kim EY, Yu B, Lavin Y, Merad M, Buenrostro JD, Brown BD, Immunological Genome Consortium Nature immunology 34099919 Nat Immunol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34099919
Ovarian cancer-derived IL-4 promotes immunotherapy resistance. Mollaoglu G, Tepper A, Falcomatà C, Potak HT, Pia L, Amabile A, Mateus-Tique J, Rabinovich N, Park MD, LaMarche NM, Brody R, Browning L, Lin JR, Zamarin D, Sorger PK, Santagata S, Merad M, Baccarini A, Brown BD Cell 39481380 Cell 2024 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/39481380
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation. Trinh VQ, Lee TF, Lemoinne S, Ray KC, Ybanez MD, Tsuchida T, Carter JK, Agudo J, Brown BD, Akat KM, Friedman SL, Lee YA Science signaling 37253090 Sci Signal 2023 May 30 https://www.ncbi.nlm.nih.gov/pubmed/37253090
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M Nature 34135508 Nature 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34135508
Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming. Aleynick M, Svensson-Arvelund J, Pantsulaia G, Kim K, Rose SA, Upadhyay R, Yellin M, Marsh H, Oreper D, Jhunjhunwala S, Moussion CC, Merad M, Brown BD, Brody JD Journal for immunotherapy of cancer 37487664 J Immunother Cancer 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37487664
Spatial CRISPR genomics identifies regulators of the tumor microenvironment. Dhainaut M, Rose SA, Akturk G, Wroblewska A, Nielsen SR, Park ES, Buckup M, Roudko V, Pia L, Sweeney R, Le Berichel J, Wilk CM, Bektesevic A, Lee BH, Bhardwaj N, Rahman AH, Baccarini A, Gnjatic S, Pe'er D, Merad M, Brown BD Cell 35290801 Cell 2022 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/35290801
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis. Dalla E, Papanicolaou M, Park MD, Barth N, Hou R, Segura-Villalobos D, Valencia Salazar L, Sun D, Forrest ARR, Casanova-Acebes M, Entenberg D, Merad M, Aguirre-Ghiso JA Cell 39378878 Cell 2024 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/39378878
A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy. Upadhyay R, Boiarsky JA, Pantsulaia G, Svensson-Arvelund J, Lin MJ, Wroblewska A, Bhalla S, Scholler N, Bot A, Rossi JM, Sadek N, Parekh S, Lagana A, Baccarini A, Merad M, Brown BD, Brody JD Cancer discovery 33334730 Cancer Discov 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33334730
Holographic Reconstruction of Axonal Pathways in the Human Brain. Petersen MV, Mlakar J, Haber SN, Parent M, Smith Y, Strick PL, Griswold MA, McIntyre CC Neuron 31708306 Neuron 2019 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/31708306
Multiple areas of the cerebral cortex influence the stomach. Levinthal DJ, Strick PL Proceedings of the National Academy of Sciences of the United States of America 32434910 Proc Natl Acad Sci U S A 2020 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/32434910
The Cortical Motor Areas and the Emergence of Motor Skills: A Neuroanatomical Perspective. Strick PL, Dum RP, Rathelot JA Annual review of neuroscience 33863253 Annu Rev Neurosci 2021 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/33863253
Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC PloS one 28686653 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/28686653
Cortical basis for skilled vocalization. Cerkevich CM, Rathelot JA, Strick PL Proceedings of the National Academy of Sciences of the United States of America 35507879 Proc Natl Acad Sci U S A 2022 May 10 https://www.ncbi.nlm.nih.gov/pubmed/35507879
The mind-body problem: Circuits that link the cerebral cortex to the adrenal medulla. Dum RP, Levinthal DJ, Strick PL Proceedings of the National Academy of Sciences of the United States of America 31871146 Proc Natl Acad Sci U S A 2019 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/31871146
Semantic segmentation of microscopic neuroanatomical data by combining topological priors with encoder-decoder deep networks. Banerjee S, Magee L, Wang D, Li X, Huo BX, Jayakumar J, Matho K, Lin MK, Ram K, Sivaprakasam M, Huang J, Wang Y, Mitra PP Nature machine intelligence 34604701 Nat Mach Intell 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/34604701
3D reconstruction and standardization of the rat facial nucleus for precise mapping of vibrissal motor networks. Guest JM, Seetharama MM, Wendel ES, Strick PL, Oberlaender M Neuroscience 28958919 Neuroscience 2018 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/28958919
Plant metabolism of nematode pheromones mediates plant-nematode interactions. Manohar M, Tenjo-Castano F, Chen S, Zhang YK, Kumari A, Williamson VM, Wang X, Klessig DF, Schroeder FC Nature communications 31924834 Nat Commun 2020 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/31924834
Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks. Yim JJ, Bose N, Meyer JM, Sommer RJ, Schroeder FC Organic letters 25782998 Org Lett 2015 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/25782998
Population Density Modulates the Duration of Reproduction of C. elegans. Wong SS, Yu J, Schroeder FC, Kim DH Current biology : CB 32442457 Curr Biol 2020 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/32442457
Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer. Rotolo A, Atherton MJ, Kasper BT, Haran KP, Mason NJ STAR protocols 34746864 STAR Protoc 2021 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/34746864
FcεRγI promotes canine CD8 chimeric antigen receptor T cell cytotoxicity through a Syk-NF-κB axis. Goodman EE, Berjis A, Sheppard NC, Mason NJ, O'Connor RS, Payne AS Molecular therapy : the journal of the American Society of Gene Therapy 41376156 Mol Ther 2026 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/41376156
Immunotherapy with genetically engineered T cells holds promise for the treatment of nonmalignant diseases in the dog. Mason NJ Journal of the American Veterinary Medical Association 38621412 J Am Vet Med Assoc 2024 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/38621412
Bite-size introduction to canine hematologic malignancies. Atherton MJ, Mason NJ Blood advances 35316831 Blood Adv 2022 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/35316831
Generation and Validation of an Antibody to Canine CD19 for Diagnostic and Future Therapeutic Purposes. Haran KP, Lockhart A, Xiong A, Radaelli E, Savickas PJ, Posey A, Mason NJ Veterinary pathology 32081102 Vet Pathol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32081102
Tumor suppressors: enhancers or suppressors of regeneration? Pomerantz JH, Blau HM Development (Cambridge, England) 23715544 Development 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23715544
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM Nature medicine 24531378 Nat Med 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24531378
An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics. Chang ACY, Chang ACH, Nicin L, Weber GJ, Holbrook C, Davies MF, Blau HM, Bertaccini EJ Anesthesia and analgesia 30198930 Anesth Analg 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/30198930
Humanizing the mdx mouse model of DMD: the long and the short of it. Yucel N, Chang AC, Day JW, Rosenthal N, Blau HM NPJ Regenerative medicine 29479480 NPJ Regen Med 2018 https://www.ncbi.nlm.nih.gov/pubmed/29479480
Short telomeres - A hallmark of heritable cardiomyopathies. Chang ACY, Blau HM Differentiation; research in biological diversity 29482077 Differentiation 2018 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/29482077
Telomerase Therapy to Reverse Cardiovascular Senescence. Nazari-Shafti TZ, Cooke JP Methodist DeBakey cardiovascular journal 26634025 Methodist Debakey Cardiovasc J 2015 Jul-Sep https://www.ncbi.nlm.nih.gov/pubmed/26634025
Therapeutic Transdifferentiation: A Novel Approach for Ischemic Syndromes. Connell JP, Kodali S, Cooke JP Methodist DeBakey cardiovascular journal 26634026 Methodist Debakey Cardiovasc J 2015 Jul-Sep https://www.ncbi.nlm.nih.gov/pubmed/26634026
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM Proceedings of the National Academy of Sciences of the United States of America 27799523 Proc Natl Acad Sci U S A 2016 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/27799523
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC Nature medicine 27089514 Nat Med 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27089514
The central role of muscle stem cells in regenerative failure with aging. Blau HM, Cosgrove BD, Ho AT Nature medicine 26248268 Nat Med 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26248268
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes. Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, Blau HM Stem cell reports 34019816 Stem Cell Reports 2021 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/34019816
Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB. Banfi A, von Degenfeld G, Gianni-Barrera R, Reginato S, Merchant MJ, McDonald DM, Blau HM FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22391130 FASEB J 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22391130
A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells. Bhutani N, Decker MN, Brady JJ, Bussat RT, Burns DM, Corbel SY, Blau HM FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23212122 FASEB J 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23212122
Redefining differentiation: Reshaping our ends. Blau HM Nature cell biology 22643873 Nat Cell Biol 2012 May 30 https://www.ncbi.nlm.nih.gov/pubmed/22643873
Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice. Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS PloS one 26133370 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/26133370
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. Ramunas J, Yakubov E, Brady JJ, Corbel SY, Holbrook C, Brandt M, Stein J, Santiago JG, Cooke JP, Blau HM FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25614443 FASEB J 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25614443
Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium. Kim PJ, Mahmoudi M, Ge X, Matsuura Y, Toma I, Metzler S, Kooreman NG, Ramunas J, Holbrook C, McConnell MV, Blau H, Harnish P, Rulifson E, Yang PC Circulation research 25654979 Circ Res 2015 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/25654979
Telomere shortening is a hallmark of genetic cardiomyopathies. Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, Blau HM Proceedings of the National Academy of Sciences of the United States of America 30150400 Proc Natl Acad Sci U S A 2018 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/30150400
Bioengineering strategies to accelerate stem cell therapeutics. Madl CM, Heilshorn SC, Blau HM Nature 29769665 Nature 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29769665
Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D The Journal of clinical investigation 28346225 J Clin Invest 2017 May 1 https://www.ncbi.nlm.nih.gov/pubmed/28346225
Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength. Ho ATV, Palla AR, Blake MR, Yucel ND, Wang YX, Magnusson KEG, Holbrook CA, Kraft PE, Delp SL, Blau HM Proceedings of the National Academy of Sciences of the United States of America 28607093 Proc Natl Acad Sci U S A 2017 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/28607093
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC European heart journal 31219556 Eur Heart J 2019 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/31219556
Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery. Miller T, Goude MC, McDevitt TC, Temenoff JS Acta biomaterialia 24121191 Acta Biomater 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24121191
Enhanced in vivo retention of low dose BMP-2 via heparin microparticle delivery does not accelerate bone healing in a critically sized femoral defect. Hettiaratchi MH, Rouse T, Chou C, Krishnan L, Stevens HY, Li MA, McDevitt TC, Guldberg RE Acta biomaterialia 28645809 Acta Biomater 2017 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/28645809
Hydrolysis and Sulfation Pattern Effects on Release of Bioactive Bone Morphogenetic Protein-2 from Heparin-Based Microparticles. Tellier LE, Miller T, McDevitt TC, Temenoff JS Journal of materials chemistry. B 27785363 J Mater Chem B 2015 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/27785363
Microparticle-mediated sequestration of cell-secreted proteins to modulate chondrocytic differentiation. Rinker TE, Philbrick BD, Hettiaratchi MH, Smalley DM, McDevitt TC, Temenoff JS Acta biomaterialia 29292168 Acta Biomater 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29292168
Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2. Hettiaratchi MH, Miller T, Temenoff JS, Guldberg RE, McDevitt TC Biomaterials 24881028 Biomaterials 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24881028
Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration. Hettiaratchi MH, Krishnan L, Rouse T, Chou C, McDevitt TC, Guldberg RE Science advances 31922007 Sci Adv 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31922007
The effect of desulfation of chondroitin sulfate on interactions with positively charged growth factors and upregulation of cartilaginous markers in encapsulated MSCs. Lim JJ, Temenoff JS Biomaterials 23570717 Biomaterials 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23570717
Design Principles for Engineering of Tissues from Human Pluripotent Stem Cells. Matthys OB, Hookway TA, McDevitt TC Current stem cell reports 27330934 Curr Stem Cell Rep 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27330934
Competitive Protein Binding Influences Heparin-Based Modulation of Spatial Growth Factor Delivery for Bone Regeneration. Hettiaratchi MH, Chou C, Servies N, Smeekens JM, Cheng A, Esancy C, Wu R, McDevitt TC, Guldberg RE, Krishnan L Tissue engineering. Part A 28338419 Tissue Eng Part A 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28338419
Chondroitin sulfate microparticles modulate transforming growth factor-β1-induced chondrogenesis of human mesenchymal stem cell spheroids. Goude MC, McDevitt TC, Temenoff JS Cells, tissues, organs 25413333 Cells Tissues Organs 2014 https://www.ncbi.nlm.nih.gov/pubmed/25413333
Engineering three-dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics. Kinney MA, Hookway TA, Wang Y, McDevitt TC Annals of biomedical engineering 24297495 Ann Biomed Eng 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24297495
Materials as stem cell regulators. Murphy WL, McDevitt TC, Engler AJ Nature materials 24845994 Nat Mater 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24845994
Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Kinney MA, McDevitt TC Trends in biotechnology 23219200 Trends Biotechnol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23219200
Cell-derived matrices for tissue engineering and regenerative medicine applications. Fitzpatrick LE, McDevitt TC Biomaterials science 25530850 Biomater Sci 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25530850
A rapid method for determining protein diffusion through hydrogels for regenerative medicine applications. Hettiaratchi MH, Schudel A, Rouse T, García AJ, Thomas SN, Guldberg RE, McDevitt TC APL bioengineering 31069307 APL Bioeng 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/31069307
Discovery and engineering of the antibody response to a prominent skin commensal. Bousbaine D, Bauman KD, Chen YE, Lalgudi PV, Nguyen TTD, Swenson JM, Yu VK, Tsang E, Conlan S, Li DB, Jbara A, Zhao A, Naziripour A, Veinbachs A, Lee YE, Phung JL, Dimas A, Jain S, Meng X, Pham TPT, McLaughlin MI, Barkal LJ, Gribonika I, Van Rompay KKA, Kong HH, Segre JA, Belkaid Y, Barnes CO, Fischbach MA Nature 39662508 Nature 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39662508
Skin autonomous antibody production regulates host-microbiota interactions. Gribonika I, Band VI, Chi L, Perez-Chaparro PJ, Link VM, Ansaldo E, Oguz C, Bousbaine D, Fischbach MA, Belkaid Y Nature 39662506 Nature 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39662506
Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution. Dingus J, Yoo DK, Kumar S, Wang Y, Kibria MG, Saghei S, Allahyari Z, Chen JW, Caputo NM, Hwang J, Chen B, Wesemann DR bioRxiv : the preprint server for biology 40909599 bioRxiv 2025 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/40909599
Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Zhang J, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Rits-Volloch S, Wang S, Sliz P, Wesemann DR, Yang W, Seaman MS, Lu J, Xiao T, Chen B Cell reports 35452593 Cell Rep 2022 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/35452593
Antibody-mediated SARS-CoV-2 entry in cultured cells. Kibria MG, Lavine CL, Tang W, Wang S, Gao H, Shi W, Zhu H, Voyer J, Rits-Volloch S, Keerti, Bi C, Peng H, Wesemann DR, Lu J, Xie H, Seaman MS, Chen B EMBO reports 38277394 EMBO Rep 2023 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/38277394
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants. Chen Y, Tong P, Whiteman N, Sanjari Moghaddam A, Zarghami M, Zuiani A, Habibi S, Gautam A, Keerti, Bi C, Xiao T, Cai Y, Chen B, Neuberg D, Wesemann DR Science immunology 35549298 Sci Immunol 2022 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/35549298
Omicron's message on vaccines: Boosting begets breadth. Wesemann DR Cell 35065712 Cell 2022 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/35065712
Somatic hypermutation generates antibody specificities beyond the primary repertoire. Zuo T, Gautam A, Saghaei S, Khobragade SN, Ahmed R, Mahdavinia A, Zarghami M, Pacheco GA, Green K, Travers M, Garcia N, Allahyari Z, Rao V, Kumar S, Novak R, Hwang JK, Wesemann DR Immunity 40339575 Immunity 2025 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/40339575
Whence and wherefore IgE? Rahman RS, Wesemann DR Immunological reviews 39041740 Immunol Rev 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39041740
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Shrock EL, Timms RT, Kula T, Mena EL, West AP Jr, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ Science (New York, N.Y.) 37023193 Science 2023 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/37023193
Predicting Differentially Methylated Cytosines in TET and DNMT3 Knockout Mutants via a Large Language Model. Sereshki S, Lonardi S bioRxiv : the preprint server for biology 39282350 bioRxiv 2024 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/39282350
MSTmap Online: enhanced usability, visualization, and accessibility. Mohseni A, Lonardi S Nucleic acids research 40266283 Nucleic Acids Res 2025 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/40266283
Fine-tuned protein language model identifies antigen-specific B cell receptors from immune repertoires. Paco K, Mendivil MP, Zhang Z, Zebardast S, Davila C, Mooney RM, Olatoyinbo P, Yang T, Bassi S, Gonzalez V, Chen E, Ashraf FB, Roman IC, Felix JR, Alam RM, Lay JA, Johal MS, Le Roch KG, Tolstorukov I, Hernandez JB, da Silva FLB, Lonardi S, Sazinsky MH, Ray A bioRxiv : the preprint server for biology 41279719 bioRxiv 2025 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/41279719
Machine learning in postgenomic biology and personalized medicine. Ray A Wiley interdisciplinary reviews. Data mining and knowledge discovery 35966173 Wiley Interdiscip Rev Data Min Knowl Discov 2022 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/35966173
Babesia duncani multi-omics identifies virulence factors and drug targets. Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu XM, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez LM, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb OS, Le Roch KG, Mamoun CB Nature microbiology 37055610 Nat Microbiol 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37055610
Biophysics of SARS-CoV-2 spike protein's receptor-binding domain interaction with ACE2 and neutralizing antibodies: from computation to functional insights. Barroso da Silva FL, Paco K, Laaksonen A, Ray A Biophysical reviews 40376405 Biophys Rev 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/40376405
Genome resource announcement of a Leptodophora sp. fungus isolated from roots of broadleaf plants in Wisconsin, USA. Yang T, Certano A, Lakshmanan V, Bassi S, Purushotham N, Nock T, Chaudhury A, Ray A Microbiology resource announcements 40698949 Microbiol Resour Announc 2025 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/40698949
Predicting differentially methylated cytosines in TET and DNMT3 knockout mutants via a large language model. Sereshki S, Lonardi S Briefings in bioinformatics 40079264 Brief Bioinform 2025 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/40079264
RAmbler resolves complex repeats in human Chromosomes 8, 19, and X. Chakravarty S, Logsdon G, Lonardi S Genome research 40037839 Genome Res 2025 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/40037839
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters. Chaturvedi S, Beutler N, Vasen G, Pablo M, Chen X, Calia G, Buie L, Rodick R, Smith D, Rogers T, Weinberger LS Proceedings of the National Academy of Sciences of the United States of America 36074824 Proc Natl Acad Sci U S A 2022 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/36074824
Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance. Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, Rogers T, Smith DM, Weinberger LS Cell 34838159 Cell 2021 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/34838159
Myeloperoxidase Inhibition Ameliorates Plaque Psoriasis in Mice. Neu SD, Strzepa A, Martin D, Sorci-Thomas MG, Pritchard KA Jr, Dittel BN Antioxidants (Basel, Switzerland) 34572970 Antioxidants (Basel) 2021 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/34572970
Negative Data, Oh No What Should I Do? How Publication of Negative Data Removes Roadblocks to Productive Research from the Perspective of Scientists Who Perform the Experiments. Beltrame AK, Caldon JJ, Gurski CJ, Hajiyeva Z, Meinhardt NJ, Sommers KC, Neu SD, Dittel BN ImmunoHorizons 37252801 Immunohorizons 2023 May 1 https://www.ncbi.nlm.nih.gov/pubmed/37252801
Ingested (Oral) Adrenocorticotropic Hormone Inhibits IL-17 in the Central Nervous System in the Mouse Model of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Dittel LJ, Dittel BN, Brod SA ImmunoHorizons 35868840 Immunohorizons 2022 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/35868840
Characterization of Definitive Regulatory B Cell Subsets by Cell Surface Phenotype, Function and Context. Neu SD, Dittel BN Frontiers in immunology 34987513 Front Immunol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34987513
Conserved Gammaherpesvirus Protein Kinase Counters the Antiviral Effects of Myeloid Cell-Specific STAT1 Expression To Promote the Establishment of Splenic B Cell Latency. Sylvester PA, Jondle CN, Stoltz KP, Lanham J, Dittel BN, Tarakanova VL Journal of virology 34132573 J Virol 2021 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/34132573
Myeloperoxidase as a Marker to Differentiate Mouse Monocyte/Macrophage Subsets. Gurski CJ, Dittel BN International journal of molecular sciences 35897821 Int J Mol Sci 2022 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/35897821
T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells. Sylvester PA, Jondle CN, Schmalzriedt DL, Dittel BN, Tarakanova VL mBio 35968944 mBio 2022 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/35968944
Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels after B cell depletion with Ocrelizumab. Gurski CJ, Hajiyeva Z, Veltri AJ, Fenton K, O'Dell S, Obeidat AZ, Dittel BN Journal of neuroimmunology 39643951 J Neuroimmunol 2025 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/39643951
Gut IgA-antibody secreting cells segregate into four Blimp1+ subsets based on differential expression of IgA and Ki-67 and are retained following prolonged αCD20 B cell depletion in mice. Neu SD, Gurski CJ, Meinhardt NJ, Jennings KC, Dittel BN Journal of immunology (Baltimore, Md. : 1950) 40073093 J Immunol 2025 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/40073093
Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in experimental autoimmune encephalomyelitis. Cai Y, Schroeder JA, Jing W, Gurski C, Williams CB, Wang S, Dittel BN, Shi Q Frontiers in immunology 36389708 Front Immunol 2022 https://www.ncbi.nlm.nih.gov/pubmed/36389708
The Problem of Microbial Dark Matter in Neonatal Sepsis. Sinnar SA, Schiff SJ Emerging infectious diseases 33080169 Emerg Infect Dis 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33080169
Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants. Paulson JN, Williams BL, Hehnly C, Mishra N, Sinnar SA, Zhang L, Ssentongo P, Mbabazi-Kabachelor E, Wijetunge DSS, von Bredow B, Mulondo R, Kiwanuka J, Bajunirwe F, Bazira J, Bebell LM, Burgoine K, Couto-Rodriguez M, Ericson JE, Erickson T, Ferrari M, Gladstone M, Guo C, Haran M, Hornig M, Isaacs AM, Kaaya BN, Kangere SM, Kulkarni AV, Kumbakumba E, Li X, Limbrick DD Jr, Magombe J, Morton SU, Mugamba J, Ng J, Olupot-Olupot P, Onen J, Peterson MR, Roy F, Sheldon K, Townsend R, Weeks AD, Whalen AJ, Quackenbush J, Ssenyonga P, Galperin MY, Almeida M, Atkins H, Warf BC, Lipkin WI, Broach JR, Schiff SJ Science translational medicine 32998967 Sci Transl Med 2020 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/32998967
Tracking and predicting the African COVID-19 pandemic. Ssentongo P, Fronterre C, Geronimo A, Greybush SJ, Mbabazi PK, Muvawala J, Nahalamba SB, Omadi PO, Opar BT, Sinnar SA, Wang Y, Whalen AJ, Held L, Jewell C, Muwanguzi AJB, Greatrex H, Norton MM, Diggle P, Schiff SJ medRxiv : the preprint server for health sciences 33236036 medRxiv 2020 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/33236036
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever. Movassagh M, Bebell LM, Burgoine K, Hehnly C, Zhang L, Moran K, Sheldon K, Sinnar SA, Mbabazi-Kabachelor E, Kumbakumba E, Bazira J, Ochora M, Mulondo R, Nsubuga BK, Weeks AD, Gladstone M, Olupot-Olupot P, Ngonzi J, Roberts DJ, Meier FA, Irizarry RA, Broach JR, Schiff SJ, Paulson JN NPJ biofilms and microbiomes 34508087 NPJ Biofilms Microbiomes 2021 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/34508087
Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid. Peterson MR, Cherukuri V, Paulson JN, Ssentongo P, Kulkarni AV, Warf BC, Monga V, Schiff SJ Journal of neurosurgery. Pediatrics 34243147 J Neurosurg Pediatr 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34243147
Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review. Groff D, Sun A, Ssentongo AE, Ba DM, Parsons N, Poudel GR, Lekoubou A, Oh JS, Ericson JE, Ssentongo P, Chinchilli VM JAMA network open 34643720 JAMA Netw Open 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34643720
Differential richness inference for 16S rRNA marker gene surveys. Kumar MS, Slud EV, Hehnly C, Zhang L, Broach J, Irizarry RA, Schiff SJ, Paulson JN Genome biology 35915508 Genome Biol 2022 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/35915508
Brain growth after surgical treatment for infant postinfectious hydrocephalus in Sub-Saharan Africa: 2-year results of a randomized trial. Schiff SJ, Kulkarni AV, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, Cherukuri V, Warf BC Journal of neurosurgery. Pediatrics 34243157 J Neurosurg Pediatr 2021 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/34243157
Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a systematic review and meta-analysis. Pelton M, Ciarletta M, Wisnousky H, Lazzara N, Manglani M, Ba DM, Chinchillli VM, Du P, Ssentongo AE, Ssentongo P General psychiatry 33912798 Gen Psychiatr 2021 https://www.ncbi.nlm.nih.gov/pubmed/33912798
Poisson Kalman filter for disease surveillance. Ebeigbe D, Berry T, Schiff SJ, Sauer T Physical review research 39211287 Phys Rev Res 2020 Oct-Dec https://www.ncbi.nlm.nih.gov/pubmed/39211287
Engineering Principles and Bioengineering in Global Health. Harper JR, Schiff SJ Neurosurgery clinics of North America 39244320 Neurosurg Clin N Am 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39244320
Infection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach. Yu M, Peterson MR, Cherukuri V, Hehnly C, Mbabazi-Kabachelor E, Mulondo R, Nsubuga Kaaya B, Broach JR, Schiff SJ, Monga V Journal of neural engineering 37253355 J Neural Eng 2023 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/37253355
Correction to Lancet Microbe 2023; published online June 19. https://doi.org/10.1016/S2666-5247(23)00106-4. The Lancet. Microbe 37414068 Lancet Microbe 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37414068
Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus. Hehnly C, Ssentongo P, Bebell LM, Burgoine K, Bazira J, Fronterre C, Kumbakumba E, Mulondo R, Mbabazi-Kabachelor E, Morton SU, Ngonzi J, Ochora M, Olupot-Olupot P, Mugamba J, Onen J, Roberts DJ, Sheldon K, Sinnar SA, Smith J, Ssenyonga P, Kiwanuka J, Paulson JN, Meier FA, Ericson JE, Broach JR, Schiff SJ International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 35150915 Int J Infect Dis 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35150915
Pan-African evolution of within- and between-country COVID-19 dynamics. Ssentongo P, Fronterre C, Geronimo A, Greybush SJ, Mbabazi PK, Muvawala J, Nahalamba SB, Omadi PO, Opar BT, Sinnar SA, Wang Y, Whalen AJ, Held L, Jewell C, Muwanguzi AJB, Greatrex H, Norton MM, Diggle PJ, Schiff SJ Proceedings of the National Academy of Sciences of the United States of America 34187879 Proc Natl Acad Sci U S A 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/34187879
Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening: A Systematic Review and Meta-analysis. Ssentongo P, Hehnly C, Birungi P, Roach MA, Spady J, Fronterre C, Wang M, Murray-Kolb LE, Al-Shaar L, Chinchilli VM, Broach JR, Ericson JE, Schiff SJ JAMA network open 34424308 JAMA Netw Open 2021 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/34424308
A Generalized Unscented Transformation for Probability Distributions. Ebeigbe D, Berry T, Norton MM, Whalen AJ, Simon D, Sauer T, Schiff SJ ArXiv 33850954 ArXiv 2021 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/33850954
Prevalence and determinants of cervical cancer screening in five sub-Saharan African countries: A population-based study. Ba DM, Ssentongo P, Musa J, Agbese E, Diakite B, Traore CB, Wang S, Maiga M Cancer epidemiology 33756434 Cancer Epidemiol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33756434
Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Ericson JE, Burgoine K, Kumbakumba E, Ochora M, Hehnly C, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni AV, Kumar MS, Magombe J, Mbabazi-Kabachelor E, Morton SU, Movassagh M, Mugamba J, Mulondo R, Natukwatsa D, Kaaya BN, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Kiwanuka J, Paulson JN, Broach JR, Schiff SJ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 37279589 Clin Infect Dis 2023 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/37279589
Brain imaging with portable low-field MRI. Kimberly WT, Sorby-Adams AJ, Webb AG, Wu EX, Beekman R, Bowry R, Schiff SJ, de Havenon A, Shen FX, Sze G, Schaefer P, Iglesias JE, Rosen MS, Sheth KN Nature reviews bioengineering 37705717 Nat Rev Bioeng 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37705717
A Systematic Review of Human Paenibacillus Infections and Comparison of Adult and Pediatric Cases. Smith D, Bastug K, Burgoine K, Broach JR, Hammershaimb EA, Hehnly C, Morton SU, Osman M, Schiff SJ, Ericson JE The Pediatric infectious disease journal 39705610 Pediatr Infect Dis J 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/39705610
Verification of operational numerical weather prediction model forecasts of precipitation using satellite rainfall estimates over Africa. Wang Y, Gueye M, Greybush SJ, Greatrex H, Whalen AJ, Ssentongo P, Zhang F, Jenkins GS, Schiff SJ Meteorological applications 39554903 Meteorol Appl 2023 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/39554903
Five-year outcomes after surgical treatment of infant postinfectious hydrocephalus in sub-Saharan Africa: results of a randomized trial. Mbabazi-Kabachelor E, Peterson MR, Mugamba J, Ssenyonga P, Onen J, Nalule E, Magombe J, Cherukuri V, Monga V, Schiff SJ, Kulkarni AV, Warf BC Journal of neurosurgery. Pediatrics 40315611 J Neurosurg Pediatr 2025 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/40315611
Generalized unscented transformation for forecasting non-Gaussian processes. Ebeigbe D, Berry T, Whalen AJ, Norton MM, Simon D, Sauer TD, Schiff SJ Physical review. E 40533957 Phys Rev E 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40533957
Gun violence incidence during the COVID-19 pandemic is higher than before the pandemic in the United States. Ssentongo P, Fronterre C, Ssentongo AE, Advani S, Heilbrunn ES, Hazelton JP, Oh JS, McCall-Hosenfeld JS, Chinchilli VM Scientific reports 34675321 Sci Rep 2021 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/34675321
Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD Jr, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT Nature reviews. Neurology 32152460 Nat Rev Neurol 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32152460
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD Jr, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT Nature medicine 33077954 Nat Med 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33077954
mirTarRnaSeq: An R/Bioconductor Statistical Package for miRNA-mRNA Target Identification and Interaction Analysis. Movassagh M, Morton SU, Hehnly C, Smith J, Doan TT, Irizarry R, Broach JR, Schiff SJ, Bailey JA, Paulson JN BMC genomics 35698050 BMC Genomics 2022 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/35698050
IDENTIFIABILITY OF INFECTION MODEL PARAMETERS EARLY IN AN EPIDEMIC. Sauer T, Berry T, Ebeigbe D, Norton MM, Whalen AJ, Schiff SJ SIAM journal on control and optimization 36338855 SIAM J Control Optim 2022 https://www.ncbi.nlm.nih.gov/pubmed/36338855
Stabilizing the return to normal behavior in an epidemic. Berry T, Ferrari M, Sauer T, Greybush SJ, Ebeigbe D, Whalen AJ, Schiff SJ medRxiv : the preprint server for health sciences 36993470 medRxiv 2023 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/36993470
Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study. Morton SU, Hehnly C, Burgoine K, Ssentongo P, Ericson JE, Kumar MS, Hagmann C, Fronterre C, Smith J, Movassagh M, Streck N, Bebell LM, Bazira J, Kumbakumba E, Bajunirwe F, Mulondo R, Mbabazi-Kabachelor E, Nsubuga BK, Natukwatsa D, Nalule E, Magombe J, Erickson T, Ngonzi J, Ochora M, Olupot-Olupot P, Onen J, Ssenyonga P, Mugamba J, Warf BC, Kulkarni AV, Lane J, Whalen AJ, Zhang L, Sheldon K, Meier FA, Kiwanuka J, Broach JR, Paulson JN, Schiff SJ The Lancet. Microbe 37348522 Lancet Microbe 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37348522
Preconception and Prenatal Environment and Growth Faltering Among Children in Uganda. Ssentongo P, Fronterre C, Ericson JE, Wang M, Al-Shaar L, Greatrex H, Omadi PO, Muvawala J, Greybush SJ, Mbabazi PK, Murray-Kolb LE, Muwanguzi AJB, Schiff SJ JAMA network open 40105840 JAMA Netw Open 2025 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/40105840
Poor surgical outcomes following Paenibacillus infant infectious hydrocephalus. Ericson JE, Natukwatsa D, Ssenyonga P, Onen J, Mugamba J, Mulondo R, Morton SU, Movassagh M, Templeton K, Hehnly C, Mbabazi-Kabachelor E, Kulkarni AV, Warf BC, Broach JR, Paulson JN, Schiff SJ Journal of neurosurgery. Pediatrics 40378477 J Neurosurg Pediatr 2025 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/40378477
Paediatric hydrocephalus. Kahle KT, Klinge PM, Koschnitzky JE, Kulkarni AV, MacAulay N, Robinson S, Schiff SJ, Strahle JM Nature reviews. Disease primers 38755194 Nat Rev Dis Primers 2024 May 16 https://www.ncbi.nlm.nih.gov/pubmed/38755194
CLIF-Net: Intersection-Guided Cross-View Fusion Network for Infection Detection From Cranial Ultrasound. Yu M, Peterson MR, Burgoine K, Harbaugh T, Olupot-Olupot P, Gladstone M, Hagmann C, Cowan FM, Weeks A, Morton SU, Mulondo R, Mbabazi-Kabachelor E, Schiff SJ, Monga V IEEE transactions on medical imaging 40372847 IEEE Trans Med Imaging 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/40372847
Poor Surgical Outcomes Following Paenibacillus Infant Infectious Hydrocephalus. Ericson JE, Natukwatsa D, Ssenyonga P, Onen J, Mugamba J, Mulondo R, Morton SU, Movassagh M, Templeton K, Hehnly C, Mbabazi-Kabachelor E, Kulkarni AV, Warf BC, Broach JR, Paulson JN, Schiff SJ medRxiv : the preprint server for health sciences 40385433 medRxiv 2025 May 9 https://www.ncbi.nlm.nih.gov/pubmed/40385433
Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus. Hehnly C, Shi A, Ssentongo P, Zhang L, Isaacs A, Morton SU, Streck N, Erdmann-Gilmore P, Tolstoy I, Townsend RR, Limbrick DD, Paulson JN, Ericson JE, Galperin MY, Schiff SJ, Broach JR mBio 36374038 mBio 2022 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/36374038
mbQTL: an R/Bioconductor package for microbial quantitative trait loci (QTL) estimation. Movassagh M, Schiff SJ, Paulson JN Bioinformatics (Oxford, England) 37707523 Bioinformatics 2023 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/37707523
Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. de Havenon A, Parasuram NR, Crawford AL, Mazurek MH, Chavva IR, Yadlapalli V, Iglesias JE, Rosen MS, Falcone GJ, Payabvash S, Sze G, Sharma R, Schiff SJ, Safdar B, Wira C, Kimberly WT, Sheth KN Journal of the American Heart Association 37218590 J Am Heart Assoc 2023 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/37218590
Existence and stability of equilibria in infectious disease dynamics with behavioral feedback. Berry T, Ferrari M, Sauer T, Greybush SJ, Ebeigbe D, Whalen AJ, Schiff SJ Physical review. E 39972741 Phys Rev E 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39972741
GLAPAL-H: Global, Local, and Parts Aware Learner for Hydrocephalus Infection Diagnosis in Low-Field MRI. Mukherjee S, Templeton K, Tindimwebwa S, Lin PY, Sutin J, Yu M, Peterson M, Truwit C, Schiff SJ, Monga V IEEE transactions on bio-medical engineering 40489263 IEEE Trans Biomed Eng 2026 Jan https://www.ncbi.nlm.nih.gov/pubmed/40489263
A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation. Lai CY, Marcel N, Yaldiko AW, Delpoux A, Hedrick SM Journal of immunology (Baltimore, Md. : 1950) 35948398 J Immunol 2022 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/35948398
Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline. Weitzel AJ, Grunwald HA, Weber C, Levina R, Gantz VM, Hedrick SM, Bier E, Cooper KL PLoS biology 34941868 PLoS Biol 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34941868
Understanding Immunity through the Lens of Disease Ecology. Hedrick SM Trends in immunology 28882454 Trends Immunol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28882454
A key control point in the T cell response to chronic infection and neoplasia: FOXO1. Marcel N, Hedrick SM Current opinion in immunology 32135399 Curr Opin Immunol 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32135399
Active genetics comes alive: Exploring the broad applications of CRISPR-based selfish genetic elements (or gene-drives): Exploring the broad applications of CRISPR-based selfish genetic elements (or gene-drives). Gantz VM, Bier E BioEssays : news and reviews in molecular, cellular and developmental biology 35686327 Bioessays 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35686327
The Imperative to Vaccinate. Hedrick SM The Journal of pediatrics 30054163 J Pediatr 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30054163
Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, Capriotti C, Cook M, Finger J, Hughes-Earle A, Harris PA, Kaiser WJ, Mocarski ES, Bertin J, Gough PJ Journal of immunology (Baltimore, Md. : 1950) 24821972 J Immunol 2014 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/24821972
Caspase-8 restricts natural killer cell accumulation during MCMV Infection. Feng Y, Daley-Bauer LP, Roback L, Potempa M, Lanier LL, Mocarski ES Medical microbiology and immunology 31115653 Med Microbiol Immunol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31115653
Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways. Daley-Bauer LP, Roback L, Crosby LN, McCormick AL, Feng Y, Kaiser WJ, Mocarski ES Proceedings of the National Academy of Sciences of the United States of America 28292903 Proc Natl Acad Sci U S A 2017 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/28292903
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES Immunity 30021146 Immunity 2018 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/30021146
Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3. Feng Y, Livingston-Rosanoff D, Roback L, Sundararajan A, Speck SH, Mocarski ES, Daley-Bauer LP Journal of immunology (Baltimore, Md. : 1950) 30194111 J Immunol 2018 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/30194111
Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1. Guo H, Gilley RP, Fisher A, Lane R, Landsteiner VJ, Ragan KB, Dovey CM, Carette JE, Upton JW, Mocarski ES, Kaiser WJ Cell death & disease 30050136 Cell Death Dis 2018 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/30050136
DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA. Upton JW, Kaiser WJ, Mocarski ES Cell host & microbe 31600504 Cell Host Microbe 2019 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/31600504
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR The Journal of biological chemistry 26100631 J Biol Chem 2015 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/26100631
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S Cell host & microbe 27321907 Cell Host Microbe 2016 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/27321907
Suppression of RIP3-dependent necroptosis by human cytomegalovirus. Omoto S, Guo H, Talekar GR, Roback L, Kaiser WJ, Mocarski ES The Journal of biological chemistry 25778401 J Biol Chem 2015 May 1 https://www.ncbi.nlm.nih.gov/pubmed/25778401
Herpes simplex virus suppresses necroptosis in human cells. Guo H, Omoto S, Harris PA, Finger JN, Bertin J, Gough PJ, Kaiser WJ, Mocarski ES Cell host & microbe 25674983 Cell Host Microbe 2015 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/25674983
Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming. Sayed N, Ospino F, Himmati F, Lee J, Chanda P, Mocarski ES, Cooke JP Stem cells (Dayton, Ohio) 28276156 Stem Cells 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28276156
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E Proceedings of the National Academy of Sciences of the United States of America 24799678 Proc Natl Acad Sci U S A 2014 May 20 https://www.ncbi.nlm.nih.gov/pubmed/24799678
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES Proceedings of the National Academy of Sciences of the United States of America 24821786 Proc Natl Acad Sci U S A 2014 May 27 https://www.ncbi.nlm.nih.gov/pubmed/24821786
Caspase-8 restricts antiviral CD8 T cell hyperaccumulation. Feng Y, Daley-Bauer LP, Roback L, Guo H, Koehler HS, Potempa M, Lanier LL, Mocarski ES Proceedings of the National Academy of Sciences of the United States of America 31285326 Proc Natl Acad Sci U S A 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31285326
Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3. Koehler H, Cotsmire S, Langland J, Kibler KV, Kalman D, Upton JW, Mocarski ES, Jacobs BL Proceedings of the National Academy of Sciences of the United States of America 29073079 Proc Natl Acad Sci U S A 2017 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/29073079
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis. Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X Nature immunology 26998763 Nat Immunol 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26998763
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J eLife 25443632 Elife 2014 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/25443632
RIP3 induces apoptosis independent of pronecrotic kinase activity. Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, Casillas LN, Haile PA, Sehon CA, Marquis RW, Upton J, Daley-Bauer LP, Roback L, Ramia N, Dovey CM, Carette JE, Chan FK, Bertin J, Gough PJ, Mocarski ES, Kaiser WJ Molecular cell 25459880 Mol Cell 2014 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/25459880
Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles. Ali M, Roback L, Mocarski ES The Journal of biological chemistry 30504227 J Biol Chem 2019 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/30504227
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans. Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA Journal of immunology (Baltimore, Md. : 1950) 25063877 J Immunol 2014 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/25063877
Manipulation of apoptosis and necroptosis signaling by herpesviruses. Guo H, Kaiser WJ, Mocarski ES Medical microbiology and immunology 25828583 Med Microbiol Immunol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25828583
Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. Andersson EI, Rajala HL, Eldfors S, Ellonen P, Olson T, Jerez A, Clemente MJ, Kallioniemi O, Porkka K, Heckman C, Loughran TP Jr, Maciejewski JP, Mustjoki S Blood cancer journal 24317090 Blood Cancer J 2013 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/24317090
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. Andersson EI, Tanahashi T, Sekiguchi N, Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K, Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A, Lagström S, Ellonen P, Fukushima N, Nishina S, Senoo N, Sakai H, Nakazawa H, Kwong YL, Loughran TP, Maciejewski JP, Mustjoki S, Ishida F Blood 27697773 Blood 2016 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/27697773
Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia. Andersson E, Kuusanmäki H, Bortoluzzi S, Lagström S, Parsons A, Rajala H, van Adrichem A, Eldfors S, Olson T, Clemente MJ, Laasonen A, Ellonen P, Heckman C, Loughran TP, Maciejewski JP, Mustjoki S Leukemia 26419508 Leukemia 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26419508
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Rajala HL, Eldfors S, Kuusanmäki H, van Adrichem AJ, Olson T, Lagström S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S Blood 23596048 Blood 2013 May 30 https://www.ncbi.nlm.nih.gov/pubmed/23596048
Somatic STAT3 mutations in large granular lymphocytic leukemia. Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmäki H, Andersson EI, Lagström S, Clemente MJ, Olson T, Jalkanen SE, Majumder MM, Almusa H, Edgren H, Lepistö M, Mattila P, Guinta K, Koistinen P, Kuittinen T, Penttinen K, Parsons A, Knowles J, Saarela J, Wennerberg K, Kallioniemi O, Porkka K, Loughran TP Jr, Heckman CA, Maciejewski JP, Mustjoki S The New England journal of medicine 22591296 N Engl J Med 2012 May 17 https://www.ncbi.nlm.nih.gov/pubmed/22591296
Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia. Afable MG 2nd, Shaik M, Sugimoto Y, Elson P, Clemente M, Makishima H, Sekeres MA, Lichtin A, Advani A, Kalaycio M, Tiu RV, O'Keefe CL, Maciejewski JP Haematologica 21606164 Haematologica 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21606164
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia. Rajala HL, Olson T, Clemente MJ, Lagström S, Ellonen P, Lundan T, Hamm DE, Zaman SA, Lopez Marti JM, Andersson EI, Jerez A, Porkka K, Maciejewski JP, Loughran TP, Mustjoki S Haematologica 25281507 Haematologica 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25281507
Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells. Ghosh Z, Huang M, Hu S, Wilson KD, Dey D, Wu JC Cancer research 21646469 Cancer Res 2011 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/21646469
Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation. Huber BC, Ransohoff JD, Ransohoff KJ, Riegler J, Ebert A, Kodo K, Gong Y, Sanchez-Freire V, Dey D, Kooreman NG, Diecke S, Zhang WY, Odegaard J, Hu S, Gold JD, Robbins RC, Wu JC Stem cells (Dayton, Ohio) 24038578 Stem Cells 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24038578
Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Sanchez-Freire V, Ebert AD, Kalisky T, Quake SR, Wu JC Nature protocols 22481529 Nat Protoc 2012 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/22481529
Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC The Journal of clinical investigation 21317531 J Clin Invest 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21317531
Engraftment of embryonic stem cells and differentiated progeny by host conditioning with total lymphoid irradiation and regulatory T cells. Pan Y, Leveson-Gower DB, de Almeida PE, Pierini A, Baker J, Florek M, Nishikii H, Kim BS, Ke R, Wu JC, Negrin RS Cell reports 25801020 Cell Rep 2015 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/25801020
Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model. Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen VC, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC Circulation research 26291556 Circ Res 2015 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/26291556
Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. Ghosh Z, Wilson KD, Wu Y, Hu S, Quertermous T, Wu JC PloS one 20126639 PLoS One 2010 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/20126639
Control of Immune Response to Allogeneic Embryonic Stem Cells by CD3 Antibody-Mediated Operational Tolerance Induction. Calderon D, Prot M, You S, Marquet C, Bellamy V, Bruneval P, Valette F, de Almeida P, Wu JC, Pucéat M, Menasché P, Chatenoud L American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 26492394 Am J Transplant 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26492394
Returns of the living dead: therapeutic action of irradiated and mitotically inactivated embryonic stem cells. Gold JD, Wu JC Circulation research 23104873 Circ Res 2012 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/23104873
In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Levi B, Hyun JS, Montoro DT, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT Proceedings of the National Academy of Sciences of the United States of America 23169671 Proc Natl Acad Sci U S A 2012 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/23169671
Immunogenicity of pluripotent stem cells and their derivatives. de Almeida PE, Ransohoff JD, Nahid A, Wu JC Circulation research 23371903 Circ Res 2013 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/23371903
Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. Su W, Zhou M, Zheng Y, Fan Y, Wang L, Han Z, Kong D, Zhao RC, Wu JC, Xiang R, Li Z Journal of cellular biochemistry 21328457 J Cell Biochem 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21328457
Comparison of human induced pluripotent and embryonic stem cells: fraternal or identical twins? Narsinh KH, Plews J, Wu JC Molecular therapy : the journal of the American Society of Gene Therapy 21455209 Mol Ther 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21455209
Effects of long-term culture on human embryonic stem cell aging. Xie X, Hiona A, Lee AS, Cao F, Huang M, Li Z, Cherry A, Pei X, Wu JC Stem cells and development 20629482 Stem Cells Dev 2011 Jan https://www.ncbi.nlm.nih.gov/pubmed/20629482
Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm. Adam M, Kooreman NG, Jagger A, Wagenhäuser MU, Mehrkens D, Wang Y, Kayama Y, Toyama K, Raaz U, Schellinger IN, Maegdefessel L, Spin JM, Hamming JF, Quax PHA, Baldus S, Wu JC, Tsao PS Arteriosclerosis, thrombosis, and vascular biology 29880489 Arterioscler Thromb Vasc Biol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29880489
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance. de Almeida PE, Meyer EH, Kooreman NG, Diecke S, Dey D, Sanchez-Freire V, Hu S, Ebert A, Odegaard J, Mordwinkin NM, Brouwer TP, Lo D, Montoro DT, Longaker MT, Negrin RS, Wu JC Nature communications 24875164 Nat Commun 2014 May 30 https://www.ncbi.nlm.nih.gov/pubmed/24875164
Pluripotent stem cells: immune to the immune system? Pearl JI, Kean LS, Davis MM, Wu JC Science translational medicine 23241742 Sci Transl Med 2012 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/23241742
Gene correction in human embryonic and induced pluripotent stem cells: promises and challenges ahead. Narsinh KH, Wu JC Molecular therapy : the journal of the American Society of Gene Therapy 20514030 Mol Ther 2010 Jun https://www.ncbi.nlm.nih.gov/pubmed/20514030
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC Cell reports 28834758 Cell Rep 2017 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/28834758
Detection of extracellular amyloid beta aggregates by an Aducanumab-based synNotch receptor: an in vitro proof-of-concept study. Bergo NJ, Lee S, Siebrand CJ, Mayeri Z, Andersen JK, Walton CC Journal of translational medicine 41214730 J Transl Med 2025 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/41214730
Chimeric Antigen Receptors Discriminate Between Tau and Distinct Amyloid-Beta Species. Siebrand CJ, Bergo NJ, Lee S, Andersen JK, Walton CC bioRxiv : the preprint server for biology 39974919 bioRxiv 2025 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/39974919
Chimeric antigen receptors discriminate between tau and distinct amyloid-beta species. Siebrand CJ, Bergo NJ, Lee S, Andersen JK, Walton CC Journal of translational medicine 40448101 J Transl Med 2025 May 30 https://www.ncbi.nlm.nih.gov/pubmed/40448101
Aβ-targeting synNotch Receptor for Alzheimer's Disease: Expanding Applications to Extracellular Protein Aggregates. Bergo NJ, Lee S, Siebrand CJ, Andersen JK, Walton CC bioRxiv : the preprint server for biology 39464071 bioRxiv 2024 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/39464071
MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination. Carpentier KS, Sheridan RM, Lucas CJ, Davenport BJ, Li FS, Lucas ED, McCarthy MK, Reynoso GV, May NA, Tamburini BAJ, Hesselberth JR, Hickman HD, Morrison TE The EMBO journal 34618370 EMBO J 2021 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/34618370
Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node. Walsh SM, Sheridan RM, Lucas ED, Doan TA, Ware BC, Schafer J, Fu R, Burchill MA, Hesselberth JR, Tamburini BAJ eLife 33843587 Elife 2021 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/33843587
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes. Tamburini B, Sheridan R, Doan T, Lucas C, Forward T, Fleming I, Uecker-Martin A, Morrison T, Hesselberth J Research square 39711554 Res Sq 2024 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/39711554
Simultaneous measurement of biochemical phenotypes and gene expression in single cells. Richer AL, Riemondy KA, Hardie L, Hesselberth JR Nucleic acids research 32286626 Nucleic Acids Res 2020 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/32286626
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes. Sheridan RM, Doan TA, Lucas CJ, Forward TS, Fleming I, Olsen VM, Qvale AM, Davenport BJ, Zarrella K, Harbell MG, Uecker-Martin A, Morrison TE, Hesselberth JR, Tamburini BAJ Nature communications 40998762 Nat Commun 2025 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/40998762
A specific and portable gene expression program underlies antigen archiving by lymphatic endothelial cells. Sheridan RM, Doan TA, Lucas C, Forward TS, Uecker-Martin A, Morrison TE, Hesselberth JR, Tamburini BAJ bioRxiv : the preprint server for biology 38617225 bioRxiv 2024 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/38617225
GPR182 is a lipoprotein receptor for dietary fat absorption. Sun Z, Torphy RJ, Miller EN, Darehshouri A, Vigil I, Terai T, Eck E, Sun Y, Guo Y, Yee EJ, Hu J, Kedl RM, Lasda EL, Hesselberth JR, MacLean P, Bruce KD, Randolph GJ, Schulick RD, Zhu Y bioRxiv : the preprint server for biology 39975353 bioRxiv 2025 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/39975353
Immunization-induced antigen archiving enhances local memory CD8+ T cell responses following an unrelated viral infection. Doan TA, Forward TS, Schafer JB, Lucas ED, Fleming I, Uecker-Martin A, Ayala E, Guthmiller JJ, Hesselberth JR, Morrison TE, Tamburini BAJ NPJ vaccines 38514656 NPJ Vaccines 2024 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/38514656
Chikungunya virus persists in joint-associated macrophages and promotes chronic disease. Zarrella KM, Sheridan RM, Ware BC, Davenport BJ, da Silva MOL, Vyshenska D, Martin AU, May NA, Weiskopf D, Hesselberth JR, Streblow DN, Greninger AL, Morrison TE Research square 40678223 Res Sq 2025 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/40678223
Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast. Sottnik JL, Shackleford MT, Nesiba CS, Richer AL, Fleischmann Z, Swartz JM, Rowland CE, Musick M, Fu R, Myler LR, Opresko PL, Mehrotra S, Sokol ES, Hesselberth JR, Diamond JR, Sikora MJ bioRxiv : the preprint server for biology 39677775 bioRxiv 2025 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/39677775
Activated polyreactive B cells are clonally expanded in autoantibody positive and patients with recent-onset type 1 diabetes. Nicholas CA, Tensun FA, Evans SA, Toole KP, Prendergast JE, Broncucia H, Hesselberth JR, Gottlieb PA, Wells KL, Smith MJ Cell reports 40117290 Cell Rep 2025 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/40117290
Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in autoantibody positive and recent-onset type 1 diabetes patients. Nicholas CA, Tensun FA, Evans SA, Toole KP, Broncucia H, Hesselberth JR, Gottlieb PA, Wells KL, Smith MJ bioRxiv : the preprint server for biology 38979376 bioRxiv 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38979376
Chikungunya virus infection disrupts lymph node lymphatic endothelial cell composition and function via MARCO. Lucas CJ, Sheridan RM, Reynoso GV, Davenport BJ, McCarthy MK, Martin A, Hesselberth JR, Hickman HD, Tamburini BA, Morrison TE JCI insight 38194268 JCI Insight 2024 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/38194268
Somatic genomic mosaicism in the brain: Identified mutations provide challenges and opportunities for the clinic. Chun J Med (New York, N.Y.) 36242998 Med 2022 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/36242998
RNA Isoform Diversity in Human Neurodegenerative Diseases. Liu CS, Park C, Ngo T, Saikumar J, Palmer CR, Shahnaee A, Romanow WJ, Chun J eNeuro 39658200 eNeuro 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39658200
Extraction and Purification of Single Nuclei from Frozen Human Brain Tissue. Palmer CR, Chun J Methods in molecular biology (Clifton, N.J.) 36399263 Methods Mol Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36399263
CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries. Abi-Ghanem C, Jonnalagadda D, Chun J, Kihara Y, Ranscht B Frontiers in cellular neuroscience 36072569 Front Cell Neurosci 2022 https://www.ncbi.nlm.nih.gov/pubmed/36072569
Human brain small extracellular vesicles contain selectively packaged, full-length mRNA. Ransom LS, Liu CS, Dunsmore E, Palmer CR, Nicodemus J, Ziomek D, Williams N, Chun J Cell reports 38578831 Cell Rep 2024 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/38578831
Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain. Nicodemus J, Liu CS, Ransom L, Tan V, Romanow W, Jimenez N, Chun J The Journal of neuroscience : the official journal of the Society for Neuroscience 40368603 J Neurosci 2025 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/40368603
Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System. Aspal M, Pushlar N, Melameka M, McVicar RN, Smith E, Ogunyamoju T, Kumar M, Marth JD, Chun J, Snyder EY, Leibel SL bioRxiv : the preprint server for biology 40060424 bioRxiv 2025 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/40060424
The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors. Alexander SPH, Davenport AP, Kelly E, Gibb AJ, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA, Abbracchio MP, Abraham GR, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bennett KA, Bernstein KE, Bettler B, Birdsall NJM, Blaho VA, Bonaventure P, Boulay F, Bousquet C, Bräuner-Osborne H, Brown AJ, Burnstock G, Busnelli M, Caló G, Caruso V, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Christopoulos A, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dautzenberg FM, Dent G, Douglas SD, Dournaud P, Dubocovich ML, Eguchi S, Escher E, Filardo EJ, Fong T, Forsman HF, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gbahou F, Gerard C, Gershengorn M, Glass M, Gloriam DE, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gruber C, Gundlach AL, Hamann J, Hanson J, Hartman DS, Hauger RL, Hay DL, Heinemann A, Heitman L, Herr DR, Hollenberg MD, Holliday ND, Holst B, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Insel PA, Jacobson KA, Jacobson LH, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kinsolving J, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Laishram L, Langenhan T, Langmead CJ, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Leurs R, Li XX, Liebscher I, Lolait SJ, Lupp A, Macrae R, Maguire JJ, Malfacini D, Manning M, Marangon D, Martemyanov K, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy PM, Nahon JL, Neubig RR, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Perry-Hauser N, Pertwee RG, Pin JP, Prossnitz ER, Qin HC, Quinn M, Raffaele S, Ramachandran R, Ray M, Reinscheid RK, Buzón AR, Rondard P, Rosenkilde MM, Rovati GE, Ruzza C, Sanger GJ, Scholz N, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Shukla AK, Singh KD, Smith CM, Smith NJ, Stäubert C, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal DM, Thomas WW, Timmermans PBMWM, Tirupula K, Toll L, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Verbalis JG, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Williams TL, Woodruff TM, Wu H, Yang C, Yao C, Ye RD, Zaidman N British journal of pharmacology 41461581 Br J Pharmacol 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41461581
RNA isoform diversity, splicing variants, and switching in single cells of the Alzheimer's disease brain. Shahnaee A, Liu CS, Ngo T, Palmer CR, Ziomek D, Park C, Tan VP, Jimenez NL, Chun J Research square 41255979 Res Sq 2025 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/41255979
isoSeQL: comparing long-read isoforms across multiple datasets. Liu CS, Chun J Bioinformatics (Oxford, England) 41452740 Bioinformatics 2026 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/41452740
Genomic Mosaicism Formed by Somatic Variation in the Aging and Diseased Brain. Costantino I, Nicodemus J, Chun J Genes 34356087 Genes (Basel) 2021 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/34356087
Altered cell and RNA isoform diversity in aging Down syndrome brains. Palmer CR, Liu CS, Romanow WJ, Lee MH, Chun J Proceedings of the National Academy of Sciences of the United States of America 34795060 Proc Natl Acad Sci U S A 2021 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/34795060
Nucleoside Reverse Transcriptase Inhibitor Exposure Is Associated with Lower Alzheimer's Disease Risk: A Retrospective Cohort Proof-of-Concept Study. Chow TW, Raupp M, Reynolds MW, Li S, Kaeser GE, Chun J Pharmaceuticals (Basel, Switzerland) 38675371 Pharmaceuticals (Basel) 2024 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/38675371
RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer's disease brain. Shahnaee A, Liu CS, Ngo T, Palmer CR, Ziomek D, Park C, Tan VP, Jimenez NL, Chun J Communications biology 41772081 Commun Biol 2026 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/41772081
Genetic architecture of natural variation of cardiac performance from flies to humans. Saha S, Spinelli L, Castro Mondragon JA, Kervadec A, Lynott M, Kremmer L, Roder L, Krifa S, Torres M, Brun C, Vogler G, Bodmer R, Colas AR, Ocorr K, Perrin L eLife 36383075 Elife 2022 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/36383075
Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome. Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR eLife 41379537 Elife 2025 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/41379537
Multiplatform modeling of atrial fibrillation identifies phospholamban as a central regulator of cardiac rhythm. Kervadec A, Kezos J, Ni H, Yu M, Marchant J, Spiering S, Kannan S, Kwon C, Andersen P, Bodmer R, Grandi E, Ocorr K, Colas AR Disease models & mechanisms 37293707 Dis Model Mech 2023 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/37293707
Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells. Missinato MA, Murphy S, Lynott M, Yu MS, Kervadec A, Chang YL, Kannan S, Loreti M, Lee C, Amatya P, Tanaka H, Huang CT, Puri PL, Kwon C, Adams PD, Qian L, Sacco A, Andersen P, Colas AR Nature communications 36973293 Nat Commun 2023 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/36973293
Nucleosome stability safeguards cell identity, stress resilience and healthy aging. Adams P, Tanaka H, McCauley B, Guida C, Lei X, Li S, Moreno T, Guillotte K, Chua Z, Abele A, Lamba A, Arnold R, Rajesh A, Teneche M, Haddadin L, Deshpande A, Deshpande A, Colas A, Kumsta C, Petrascheck M, Bodmer R, Dang W Research square 41333395 Res Sq 2025 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/41333395
Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity. Birker K, Ge S, Kirkland NJ, Theis JL, Marchant J, Fogarty ZC, Missinato MA, Kalvakuri S, Grossfeld P, Engler AJ, Ocorr K, Nelson TJ, Colas AR, Olson TM, Vogler G, Bodmer R eLife 37404133 Elife 2023 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/37404133
Nucleosome stability safeguards cell identity, stress resilience and healthy aging. Tanaka H, McCauley BS, Guida C, Lei X, Li S, Moreno TM, Guillotte K, Chua ZM, Abele A, Lamba A, Arnold R, Rajesh A, Teneche MG, Haddadin L, Deshpande A, Deshpande AJ, Colas A, Kumsta C, Petrascheck M, Bodmer R, Dang W, Adams PD bioRxiv : the preprint server for biology 41000743 bioRxiv 2025 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/41000743
On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan. Gladyshev VN BioEssays : news and reviews in molecular, cellular and developmental biology 22915358 Bioessays 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22915358
Reprogramming to recover youthful epigenetic information and restore vision. Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA Nature 33268865 Nature 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33268865
Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast. Kaya A, Phua CZJ, Lee M, Wang L, Tyshkovskiy A, Ma S, Barre B, Liu W, Harrison BR, Zhao X, Zhou X, Wasko BM, Bammler TK, Promislow DE, Kaeberlein M, Gladyshev VN eLife 34751131 Elife 2021 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/34751131
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19. Ying K, Zhai R, Pyrkov TV, Shindyapina AV, Mariotti M, Fedichev PO, Shen X, Gladyshev VN Communications medicine 35602207 Commun Med (Lond) 2021 https://www.ncbi.nlm.nih.gov/pubmed/35602207
Metabolism, homeostasis, and aging. Moldakozhayev A, Gladyshev VN Trends in endocrinology and metabolism: TEM 36681595 Trends Endocrinol Metab 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36681595
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation. Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN eLife 38517750 Elife 2024 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/38517750
Molecular Damage in Aging. Gladyshev VN, Kritchevsky SB, Clarke SG, Cuervo AM, Fiehn O, de Magalhães JP, Mau T, Maes M, Moritz R, Niedernhofer LJ, Van Schaftingen E, Tranah GJ, Walsh K, Yura Y, Zhang B, Cummings SR Nature aging 36846190 Nat Aging 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/36846190
Four anti-aging drugs and calorie-restricted diet produce parallel effects in fat, brain, muscle, macrophages, and plasma of young mice. Li X, McPherson M, Hager M, Lee M, Chang P, Miller RA GeroScience 36920743 Geroscience 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/36920743
DNA methylation networks underlying mammalian traits. Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter G, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chavez AS, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke S, Cook JA, Cooper LN, Cossette ML, Day J, DeYoung J, Dirocco S, Dold C, Dunnum JL, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Fei Z, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Goya RG, Grant MJ, Green CB, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaître JF, Levine AJ, Li X, Li C, Lim AR, Lin DTS, Lindemann DM, Liphardt SW, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Murphy WJ, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, Nyamsuren B, O'Brien JK, Ginn PO, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pedersen AB, Pellegrini M, Peters KJ, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Shafer ABA, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmohammadi E, Spangler ML, Spriggs M, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Vu H, Wallingford MC, Wang N, Wilkinson GS, Williams RW, Yan Q, Yao M, Young BG, Zhang B, Zhang Z, Zhao Y, Zhao P, Zhou W, Zoller JA, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S Science (New York, N.Y.) 37561875 Science 2023 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/37561875
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Kerepesi C, Zhang B, Lee SG, Trapp A, Gladyshev VN Science advances 34172448 Sci Adv 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34172448
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions. Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN Cell metabolism 28380383 Cell Metab 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28380383
Applying deductive reasoning and the principles of particle physics to aging research. Moldakozhayev A, Tskhay A, Gladyshev VN Aging 34543232 Aging (Albany NY) 2021 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/34543232
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna. Shindyapina AV, Cho Y, Kaya A, Tyshkovskiy A, Castro JP, Deik A, Gordevicius J, Poganik JR, Clish CB, Horvath S, Peshkin L, Gladyshev VN Science advances 36112674 Sci Adv 2022 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/36112674
Emerging rejuvenation strategies-Reducing the biological age. Zhang B, Trapp A, Kerepesi C, Gladyshev VN Aging cell 34972247 Aging Cell 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34972247
Biomarkers of aging for the identification and evaluation of longevity interventions. Moqri M, Herzog C, Poganik JR, Biomarkers of Aging Consortium, Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN Cell 37657418 Cell 2023 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/37657418
Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice. Li X, Shi X, McPherson M, Hager M, Garcia GG, Miller RA Aging cell 35930768 Aging Cell 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35930768
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan. Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S bioRxiv : the preprint server for biology 38585858 bioRxiv 2024 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/38585858
COVID-19 is an emergent disease of aging. Santesmasses D, Castro JP, Zenin AA, Shindyapina AV, Gerashchenko MV, Zhang B, Kerepesi C, Yim SH, Fedichev PO, Gladyshev VN Aging cell 33006233 Aging Cell 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33006233
Multi-omic rejuvenation and life span extension on exposure to youthful circulation. Zhang B, Lee DE, Trapp A, Tyshkovskiy A, Lu AT, Bareja A, Kerepesi C, McKay LK, Shindyapina AV, Dmitriev SE, Baht GS, Horvath S, Gladyshev VN, White JP Nature aging 37500973 Nat Aging 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37500973
Validation of biomarkers of aging. Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hägg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L Nature medicine 38355974 Nat Med 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38355974
COVID-19 mortality rate in children is U-shaped. Khera N, Santesmasses D, Kerepesi C, Gladyshev VN Aging 34411000 Aging (Albany NY) 2021 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/34411000
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats. Emmrich S, Tolibzoda Zakusilo F, Trapp A, Zhou X, Zhang Q, Irving EM, Drage MG, Zhang Z, Gladyshev VN, Seluanov A, Gorbunova V Aging cell 34596321 Aging Cell 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34596321
Profiling epigenetic age in single cells. Trapp A, Kerepesi C, Gladyshev VN Nature aging 36211119 Nat Aging 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/36211119
The long and winding road of reprogramming-induced rejuvenation. Yücel AD, Gladyshev VN Nature communications 38431638 Nat Commun 2024 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/38431638
Biological age is increased by stress and restored upon recovery. Poganik JR, Zhang B, Baht GS, Tyshkovskiy A, Deik A, Kerepesi C, Yim SH, Lu AT, Haghani A, Gong T, Hedman AM, Andolf E, Pershagen G, Almqvist C, Clish CB, Horvath S, White JP, Gladyshev VN Cell metabolism 37086720 Cell Metab 2023 May 2 https://www.ncbi.nlm.nih.gov/pubmed/37086720
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan. Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S Nature aging 40055478 Nat Aging 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/40055478
Age-associated clonal B cells drive B cell lymphoma in mice. Castro JP, Shindyapina AV, Barbieri A, Ying K, Strelkova OS, Paulo JA, Tyshkovskiy A, Meinl R, Kerepesi C, Petrashen AP, Mariotti M, Meer MV, Hu Y, Karamyshev A, Losyev G, Galhardo M, Logarinho E, Indzhykulian AA, Gygi SP, Sedivy JM, Manis JP, Gladyshev VN Nature aging 39117982 Nat Aging 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39117982
Universal DNA methylation age across mammalian tissues. Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG, Zhang B, Zhang Z, Zhao P, Zhao Y, Zhou W, Zimmermann J, Ernst J, Raj K, Horvath S Nature aging 37563227 Nat Aging 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37563227
Causality-enriched epigenetic age uncouples damage and adaptation. Ying K, Liu H, Tarkhov AE, Sadler MC, Lu AT, Moqri M, Horvath S, Kutalik Z, Shen X, Gladyshev VN Nature aging 38243142 Nat Aging 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38243142
Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae. Itakura AK, Chakravarty AK, Jakobson CM, Jarosz DF Molecular cell 31757756 Mol Cell 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31757756
An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning. McKay A, Costa EK, Chen J, Hu CK, Chen X, Bedbrook CN, Khondker RC, Thielvoldt M, Priya Singh P, Wyss-Coray T, Brunet A eLife 36354233 Elife 2022 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/36354233
Defining the condensate landscape of fusion oncoproteins. Tripathi S, Shirnekhi HK, Gorman SD, Chandra B, Baggett DW, Park CG, Somjee R, Lang B, Hosseini SMH, Pioso BJ, Li Y, Iacobucci I, Gao Q, Edmonson MN, Rice SV, Zhou X, Bollinger J, Mitrea DM, White MR, McGrail DJ, Jarosz DF, Yi SS, Babu MM, Mullighan CG, Zhang J, Sahni N, Kriwacki RW Nature communications 37770423 Nat Commun 2023 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/37770423
Rapid and precise genome engineering in a naturally short-lived vertebrate. Bedbrook CN, Nath RD, Nagvekar R, Deisseroth K, Brunet A eLife 37191291 Elife 2023 May 9 https://www.ncbi.nlm.nih.gov/pubmed/37191291
Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties. Harel I, Chen YR, Ziv I, Singh PP, Heinzer D, Navarro Negredo P, Goshtchevsky U, Wang W, Astre G, Moses E, McKay A, Machado BE, Hebestreit K, Yin S, Sánchez Alvarado A, Jarosz DF, Brunet A Cell reports 38810650 Cell Rep 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38810650
A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness. Jakobson CM, Hartl J, Trébulle P, Mülleder M, Jarosz DF, Ralser M Science (New York, N.Y.) 41066569 Science 2025 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/41066569
A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program. Chakravarty AK, Smejkal T, Itakura AK, Garcia DM, Jarosz DF Molecular cell 31757755 Mol Cell 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31757755
Old and new models for the study of human ageing. Brunet A Nature reviews. Molecular cell biology 32572179 Nat Rev Mol Cell Biol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32572179
A prion accelerates proliferation at the expense of lifespan. Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF eLife 34545808 Elife 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34545808
Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate. Chen YR, Harel I, Singh PP, Ziv I, Moses E, Goshtchevsky U, Machado BE, Brunet A, Jarosz DF Developmental cell 38810654 Dev Cell 2024 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/38810654
Lifelong behavioral screen reveals an architecture of vertebrate aging. Bedbrook CN, Nath RD, Zhang L, Linderman SW, Brunet A, Deisseroth K Science (New York, N.Y.) 41818367 Science 2026 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/41818367
Life-long behavioral screen reveals an architecture of vertebrate aging. Bedbrook CN, Nath RD, Zhang L, Linderman SW, Brunet A, Deisseroth K bioRxiv : the preprint server for biology 41332731 bioRxiv 2025 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/41332731
Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation. Finet O, Yague-Sanz C, Krüger LK, Tran P, Migeot V, Louski M, Nevers A, Rougemaille M, Sun J, Ernst FGM, Wacheul L, Wery M, Morillon A, Dedon P, Lafontaine DLJ, Hermand D Molecular cell 34798057 Mol Cell 2022 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/34798057
Phenoxy Radical Reactivity of Nucleic Acids: Practical Implications for Biotinylation. Wilbanks B, Garcia B, Byrne S, Dedon P, Maher LJ 3rd Chembiochem : a European journal of chemical biology 33368926 Chembiochem 2021 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/33368926
Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans. Guilbaud A, Ghanegolmohammadi F, Wang Y, Leng J, Kreymerman A, Gamboa Varela J, Garbern J, Elwell H, Cao F, Ricci-Blair EM, Liang C, Balamkundu S, Vidoudez C, DeMott MS, Bedi K, Margulies KB, Bennett DA, Palmer AA, Barkley-Levenson A, Lee RT, Dedon PC Nucleic acids research 37843128 Nucleic Acids Res 2023 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/37843128
Regenerative medicine: Of fish and men. Rando TA Nature chemical biology 24441638 Nat Chem Biol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24441638
Stem cells as vehicles for youthful regeneration of aged tissues. Rando TA, Wyss-Coray T The journals of gerontology. Series A, Biological sciences and medical sciences 24833585 J Gerontol A Biol Sci Med Sci 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24833585
Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling. van Velthoven CTJ, Rando TA Cell stem cell 30735649 Cell Stem Cell 2019 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/30735649
Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation. Tang H, L Kennedy C, Lee M, Gao Y, Xia H, Olguin F, Fraga DA, Ayers K, Choi S, Kim M, Tehrani A, Sowb YA, Rando TA, Shrager JB Scientific reports 29109401 Sci Rep 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/29109401
Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Luo D, de Morree A, Boutet S, Quach N, Natu V, Rustagi A, Rando TA Proceedings of the National Academy of Sciences of the United States of America 28351977 Proc Natl Acad Sci U S A 2017 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/28351977
Interaction between epigenetic and metabolism in aging stem cells. Brunet A, Rando TA Current opinion in cell biology 28129586 Curr Opin Cell Biol 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28129586
An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. Quarta M, Brett JO, DiMarco R, De Morree A, Boutet SC, Chacon R, Gibbons MC, Garcia VA, Su J, Shrager JB, Heilshorn S, Rando TA Nature biotechnology 27240197 Nat Biotechnol 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27240197
Mimicking the niche: cytokines expand muscle stem cells. Quarta M, Rando TA Cell research 26113258 Cell Res 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26113258
Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells. Wosczyna MN, Perez Carbajal EE, Wagner MW, Paredes S, Konishi CT, Liu L, Wang TT, Walsh RA, Gan Q, Morrissey CS, Rando TA Cell stem cell 33945794 Cell Stem Cell 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/33945794
Body Mass Index and Postacute Sequelae of SARS-CoV-2 Infection in Children and Young Adults. Zhou T, Zhang B, Zhang D, Wu Q, Chen J, Li L, Lu Y, Becich MJ, Blecker S, Chilukuri N, Chrischilles EA, Chu H, Corsino L, Geary CR, Hornig M, Hornig-Rohan MM, Kim S, Liebovitz DM, Lorman V, Luo C, Morizono H, Mosa ASM, Pajor NM, Rao S, Razzaghi H, Suresh S, Tedla YG, Utset LV, Wang Y, Williams DA, Witvliet MG, Mangarelli C, Jhaveri R, Forrest CB, Chen Y JAMA network open 39466241 JAMA Netw Open 2024 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/39466241
Communication-efficient federated learning of temporal effects on opioid use disorder with data from distributed research networks. Liang CJ, Luo C, Kranzler HR, Bian J, Chen Y Journal of the American Medical Informatics Association : JAMIA 39864407 J Am Med Inform Assoc 2025 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/39864407
Translational strategies and challenges in regenerative medicine. Dimmeler S, Ding S, Rando TA, Trounson A Nature medicine 25100527 Nat Med 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/25100527
Alive and well? Exploring disease by studying lifespan. Brett JO, Rando TA Current opinion in genetics & development 25005743 Curr Opin Genet Dev 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/25005743
Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting. Liu L, Cheung TH, Charville GW, Rando TA Nature protocols 26401916 Nat Protoc 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26401916
Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Quarta M, Cromie M, Chacon R, Blonigan J, Garcia V, Akimenko I, Hamer M, Paine P, Stok M, Shrager JB, Rando TA Nature communications 28631758 Nat Commun 2017 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/28631758
Fleeting factors, turning back time. Rando TA Nature biotechnology 28267729 Nat Biotechnol 2017 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/28267729
Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging. Liu L, Kim S, Buckley MT, Reyes JM, Kang J, Tian L, Wang M, Lieu A, Mao M, Rodriguez-Mateo C, Ishak HD, Jeong M, Wu JC, Goodell MA, Brunet A, Rando TA Cell stem cell 37080206 Cell Stem Cell 2023 May 4 https://www.ncbi.nlm.nih.gov/pubmed/37080206
Stem cells and healthy aging. Goodell MA, Rando TA Science (New York, N.Y.) 26785478 Science 2015 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/26785478
Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. Tang AH, Rando TA The EMBO journal 25316028 EMBO J 2014 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/25316028
Transcriptional Profiling of Quiescent Muscle Stem Cells In Vivo. van Velthoven CTJ, de Morree A, Egner IM, Brett JO, Rando TA Cell reports 29141228 Cell Rep 2017 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/29141228
mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H Cell stem cell 29220665 Cell Stem Cell 2017 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/29220665
A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration. Wosczyna MN, Rando TA Developmental cell 30016618 Dev Cell 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30016618
Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. Liu L, Charville GW, Cheung TH, Yoo B, Santos PJ, Schroeder M, Rando TA Cell stem cell 30244867 Cell Stem Cell 2018 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/30244867
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Stearns-Reider KM, D'Amore A, Beezhold K, Rothrauff B, Cavalli L, Wagner WR, Vorp DA, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan RS, Ambrosio F Aging cell 28371268 Aging Cell 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28371268
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA Nature 24870234 Nature 2014 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/24870234
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1. Brett JO, Arjona M, Ikeda M, Quarta M, de Morrée A, Egner IM, Perandini LA, Ishak HD, Goshayeshi A, Benjamin DI, Both P, Rodríguez-Mateo C, Betley MJ, Wyss-Coray T, Rando TA Nature metabolism 32601609 Nat Metab 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32601609
Quantifying and correcting bias due to outcome dependent self-reported weights in longitudinal study of weight loss interventions. Tong J, Duan R, Li R, Luo C, Moore JH, Zhu J, Foster GD, Volpp KG, Yancy WS Jr, Shaw PA, Chen Y Scientific reports 37925516 Sci Rep 2023 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/37925516
UTX in muscle regeneration--the right dose and the right time. Liu L, Rando TA The Journal of clinical investigation 26999609 J Clin Invest 2016 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/26999609
Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis. Mueller AA, van Velthoven CT, Fukumoto KD, Cheung TH, Rando TA Nature 27894125 Nature 2016 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/27894125
Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Liu L, Cheung TH, Charville GW, Hurgo BM, Leavitt T, Shih J, Brunet A, Rando TA Cell reports 23810552 Cell Rep 2013 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/23810552
Cardiac aging and rejuvenation--a sense of humors? Rando TA, Finkel T The New England journal of medicine 23924010 N Engl J Med 2013 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/23924010
The JAK-STAT pathway is critical in ventilator-induced diaphragm dysfunction. Tang H, Smith IJ, Hussain SN, Goldberg P, Lee M, Sugiarto S, Godinez GL, Singh BK, Payan DG, Rando TA, Kinsella TM, Shrager JB Molecular medicine (Cambridge, Mass.) 25286450 Mol Med 2015 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/25286450
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Sarkar TJ, Quarta M, Mukherjee S, Colville A, Paine P, Doan L, Tran CM, Chu CR, Horvath S, Qi LS, Bhutani N, Rando TA, Sebastiano V Nature communications 32210226 Nat Commun 2020 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/32210226
Biomechanics show stem cell necessity for effective treatment of volumetric muscle loss using bioengineered constructs. Quarta M, Cromie Lear MJ, Blonigan J, Paine P, Chacon R, Rando TA NPJ Regenerative medicine 30323949 NPJ Regen Med 2018 https://www.ncbi.nlm.nih.gov/pubmed/30323949
Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. Wosczyna MN, Konishi CT, Perez Carbajal EE, Wang TT, Walsh RA, Gan Q, Wagner MW, Rando TA Cell reports 31091443 Cell Rep 2019 May 14 https://www.ncbi.nlm.nih.gov/pubmed/31091443
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist. Liu L, Rodriguez-Mateo C, Huang P, Huang A, Lieu A, Mao M, Chung M, Yang S, Yu K, Charville GW, Gan Q, Rando TA Proceedings of the National Academy of Sciences of the United States of America 34493660 Proc Natl Acad Sci U S A 2021 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/34493660
Exercise plasma boosts memory and dampens brain inflammation via clusterin. De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, Yang AC, Hahn O, Lu N, Vest RT, Bonanno LN, Yerra L, Zhang L, Saw NL, Fairchild JK, Lee D, Zhang H, McAlpine PL, Contrepois K, Shamloo M, Elias JE, Rando TA, Wyss-Coray T Nature 34880498 Nature 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34880498
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL Glia 23536313 Glia 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23536313
Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers. Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D The Journal of neuroscience : the official journal of the Society for Neuroscience 27581448 J Neurosci 2016 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/27581448
Microglial signatures and their role in health and disease. Butovsky O, Weiner HL Nature reviews. Neuroscience 30206328 Nat Rev Neurosci 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30206328
Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J Nature communications 23799536 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23799536
Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL Nature neuroscience 24316888 Nat Neurosci 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24316888
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Butovsky O, Jedrychowski MP, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, Greco DJ, Wu PM, Doykan CE, Kiner O, Lawson RJ, Frosch MP, Pochet N, Fatimy RE, Krichevsky AM, Gygi SP, Lassmann H, Berry J, Cudkowicz ME, Weiner HL Annals of neurology 25381879 Ann Neurol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25381879
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ Nature medicine 25216636 Nat Med 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25216636
Identification and characterization of latency-associated peptide-expressing γδ T cells. Rezende RM, da Cunha AP, Kuhn C, Rubino S, M'Hamdi H, Gabriely G, Vandeventer T, Liu S, Cialic R, Pinheiro-Rosa N, Oliveira RP, Gaublomme JT, Obholzer N, Kozubek J, Pochet N, Faria AMC, Weiner HL Nature communications 26644347 Nat Commun 2015 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/26644347
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O Immunity 28930663 Immunity 2017 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/28930663
Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer's disease mouse models. Wasén C, Beauchamp LC, Vincentini J, Li S, LeServe DS, Gauthier C, Lopes JR, Moreira TG, Ekwudo MN, Yin Z, da Silva P, Krishnan RK, Butovsky O, Cox LM, Weiner HL Nature communications 38719797 Nat Commun 2024 May 8 https://www.ncbi.nlm.nih.gov/pubmed/38719797
Age and the association of dementia-related pathology with trajectories of cognitive decline. Jansen WJ, Wilson RS, Visser PJ, Nag S, Schneider JA, James BD, Leurgans SE, Capuano AW, Bennett DA, Boyle PA Neurobiology of aging 29078129 Neurobiol Aging 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29078129
Acute microglia ablation induces neurodegeneration in the somatosensory system. Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL Nature communications 30385785 Nat Commun 2018 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/30385785
Drosophila life span and physiology are modulated by sexual perception and reward. Gendron CM, Kuo TH, Harvanek ZM, Chung BY, Yew JY, Dierick HA, Pletcher SD Science (New York, N.Y.) 24292624 Science 2014 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/24292624
Longevity is impacted by growth hormone action during early postnatal period. Sun LY, Fang Y, Patki A, Koopman JJ, Allison DB, Hill CM, Masternak MM, Darcy J, Wang J, McFadden S, Bartke A eLife 28675141 Elife 2017 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/28675141
Oxidative costs of reproduction: Oxidative stress in mice fed standard and low antioxidant diets. Vaanholt LM, Milne A, Zheng Y, Hambly C, Mitchell SE, Valencak TG, Allison DB, Speakman JR Physiology & behavior 26569452 Physiol Behav 2016 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/26569452
Chronic subordination stress induces hyperphagia and disrupts eating behavior in mice modeling binge-eating-like disorder. Razzoli M, Sanghez V, Bartolomucci A Frontiers in nutrition 25621284 Front Nutr 2015 https://www.ncbi.nlm.nih.gov/pubmed/25621284
Circadian disruption of hippocampus in an early senescence male mouse model. Davis JA, Paul JR, Mokashi MV, Yates SA, Mount DJ, Munir HA, Goode LK, Young ME, Allison DB, Gamble KL Pharmacology, biochemistry, and behavior 35447158 Pharmacol Biochem Behav 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35447158
Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling. Ostojic I, Boll W, Waterson MJ, Chan T, Chandra R, Pletcher SD, Alcedo J Proceedings of the National Academy of Sciences of the United States of America 24847072 Proc Natl Acad Sci U S A 2014 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/24847072
Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SD Proceedings of the National Academy of Sciences of the United States of America 24821805 Proc Natl Acad Sci U S A 2014 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/24821805
Second-hand eating? Maternal perception of the food environment affects reproductive investment in mice. Schwartz TS, Gainer R, Dohm ED, Johnson MS, Wyss JM, Allison DB Obesity (Silver Spring, Md.) 25864567 Obesity (Silver Spring) 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25864567
Adaptive Physiological Response to Perceived Scarcity as a Mechanism of Sensory Modulation of Life Span. Waterson MJ, Chan TP, Pletcher SD The journals of gerontology. Series A, Biological sciences and medical sciences 25878032 J Gerontol A Biol Sci Med Sci 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/25878032
Effect of Food Predictability on Life Span in Male Mice. Rowland NE, Robertson KL, Minaya D, Minervini V, Cervantez M, Kaiser KA, Allison DB The journals of gerontology. Series A, Biological sciences and medical sciences 30289438 J Gerontol A Biol Sci Med Sci 2019 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/30289438
Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis. Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A Molecular metabolism 26844204 Mol Metab 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26844204
Effects of fluctuating temperature and food availability on reproduction and lifespan. Schwartz TS, Pearson P, Dawson J, Allison DB, Gohlke JM Experimental gerontology 27364192 Exp Gerontol 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27364192
Sex-dependent Differences in Liver and Gut Metabolomic Profiles With Acarbose and Calorie Restriction in C57BL/6 Mice. Gibbs VK, Brewer RA, Miyasaki ND, Patki A, Smith DL Jr The journals of gerontology. Series A, Biological sciences and medical sciences 28651373 J Gerontol A Biol Sci Med Sci 2018 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/28651373
No Significant Effect of Maternal Perception of the Food Environment on Reproductive Success or Pup Outcomes in C57BL/6J Mice. Gibbs VK, Schwartz TS, Johnson MS, Patki A, Nagy TR, George BJ, Allison DB Obesity (Silver Spring, Md.) 29476611 Obesity (Silver Spring) 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29476611
Body Mass Index and Subjective Social Status: The Coronary Artery Risk Development in Young Adults Study. Dhurandhar EJ, Pavela G, Kaiser KA, Dutton GR, Fontaine KR, Kim D, Shikany JM, Allison DB, Lewis CE Obesity (Silver Spring, Md.) 29280341 Obesity (Silver Spring) 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29280341
Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone. Speakman JR, Mitchell SE, Mazidi M Experimental gerontology 27006163 Exp Gerontol 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27006163
The effect of a pharmaceutical ghrelin agonist on lifespan in C57BL/6J male mice: A controlled experiment. Kaiser KA, Kadish I, van Groen T, Smith DL Jr, Dickinson S, Henschel B, Parker ES, Brown AW, Allison DB Aging cell 36734122 Aging Cell 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36734122
The multiple roles of life stress in metabolic disorders. Kivimäki M, Bartolomucci A, Kawachi I Nature reviews. Endocrinology 36224493 Nat Rev Endocrinol 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36224493
A computational approach to studying ageing at the individual level. Harvanek ZM, Mourão MA, Schnell S, Pletcher SD Proceedings. Biological sciences 26865300 Proc Biol Sci 2016 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/26865300
The Dichotomous Effect of Chronic Stress on Obesity. Razzoli M, Bartolomucci A Trends in endocrinology and metabolism: TEM 27162125 Trends Endocrinol Metab 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27162125
Social stress shortens lifespan in mice. Razzoli M, Nyuyki-Dufe K, Gurney A, Erickson C, McCallum J, Spielman N, Marzullo M, Patricelli J, Kurata M, Pope EA, Touma C, Palme R, Largaespada DA, Allison DB, Bartolomucci A Aging cell 29806171 Aging Cell 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29806171
Innovative approaches in cognitive aging. Austad SN, Wood MA, Villeda SA, Voss JL, Sahay A, Albert M Neurobiology of aging 31277894 Neurobiol Aging 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31277894
Serotonin signaling mediates protein valuation and aging. Ro J, Pak G, Malec PA, Lyu Y, Allison DB, Kennedy RT, Pletcher SD eLife 27572262 Elife 2016 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/27572262
Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance. Jothery AH, Vaanholt LM, Mody N, Arnous A, Lykkesfeldt J, Bünger L, Hill WG, Mitchell SE, Allison DB, Speakman JR Scientific reports 27841266 Sci Rep 2016 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/27841266
Targeting glucose metabolism for healthy aging. Brewer RA, Gibbs VK, Smith DL Jr Nutrition and healthy aging 28035340 Nutr Healthy Aging 2016 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/28035340
Diurnal, metabolic and thermogenic alterations in a murine model of accelerated aging. Allison DB, Ren G, Peliciari-Garcia RA, Mia S, McGinnis GR, Davis J, Gamble KL, Kim JA, Young ME Chronobiology international 32819176 Chronobiol Int 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32819176
Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila. Lee JE, Rayyan M, Liao A, Edery I, Pletcher SD Cell reports 28700947 Cell Rep 2017 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/28700947
Nutrition and energetics in rodent longevity research. Gibbs VK, Smith DL Jr Experimental gerontology 27073168 Exp Gerontol 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27073168
Sex Differences in Lifespan. Austad SN, Fischer KE Cell metabolism 27304504 Cell Metab 2016 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/27304504
Stress, overeating, and obesity: Insights from human studies and preclinical models. Razzoli M, Pearson C, Crow S, Bartolomucci A Neuroscience and biobehavioral reviews 28292531 Neurosci Biobehav Rev 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28292531
Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse model. Kunath N, van Groen T, Allison DB, Kumar A, Dozier-Sharpe M, Kadish I Scientific reports 26090621 Sci Rep 2015 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/26090621
FLIC: high-throughput, continuous analysis of feeding behaviors in Drosophila. Ro J, Harvanek ZM, Pletcher SD PloS one 24978054 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24978054
Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory. Mitchell SE, Simpson M, Coulet L, Gouedard S, Hambly C, Morimoto J, Allison DB, Speakman JR Proceedings of the National Academy of Sciences of the United States of America 39374394 Proc Natl Acad Sci U S A 2024 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/39374394
Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress. Razzoli M, Nyuyki-Dufe K, Chen BH, Bartolomucci A Proceedings of the National Academy of Sciences of the United States of America 37043532 Proc Natl Acad Sci U S A 2023 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/37043532
Not feeling the heat? Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature. Osorio M J, Mitchell SE, Hambly C, Allison DB, Speakman JR Appetite 38759755 Appetite 2024 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/38759755
A fully automated microfluidic femtosecond laser axotomy platform for nerve regeneration studies in C. elegans. Gokce SK, Guo SX, Ghorashian N, Everett WN, Jarrell T, Kottek A, Bovik AC, Ben-Yakar A PloS one 25470130 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25470130
An automated microfluidic multiplexer for fast delivery of C. elegans populations from multiwells. Ghorashian N, Gökçe SK, Guo SX, Everett WN, Ben-Yakar A PloS one 24069313 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24069313
Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans. Ben-Yakar A, Chronis N, Lu H Current opinion in neurobiology 19896831 Curr Opin Neurobiol 2009 Oct https://www.ncbi.nlm.nih.gov/pubmed/19896831
Axonal regeneration proceeds through specific axonal fusion in transected C. elegans neurons. Neumann B, Nguyen KC, Hall DH, Ben-Yakar A, Hilliard MA Developmental dynamics : an official publication of the American Association of Anatomists 21416556 Dev Dyn 2011 Jun https://www.ncbi.nlm.nih.gov/pubmed/21416556
Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies. Guo SX, Bourgeois F, Chokshi T, Durr NJ, Hilliard MA, Chronis N, Ben-Yakar A Nature methods 18408725 Nat Methods 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18408725
Ultrasound measurements of cavitation bubble radius for femtosecond laser-induced breakdown in water. Aglyamov SR, Karpiouk AB, Bourgeois F, Ben-Yakar A, Emelianov SY Optics letters 18552957 Opt Lett 2008 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/18552957
Quantitative ultrasound method to detect and monitor laser-induced cavitation bubbles. Karpiouk AB, Aglyamov SR, Bourgeois F, Ben-Yakar A, Emelianov SY Journal of biomedical optics 18601556 J Biomed Opt 2008 May-Jun https://www.ncbi.nlm.nih.gov/pubmed/18601556
Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model. Mondal S, Hegarty E, Martin C, Gökçe SK, Ghorashian N, Ben-Yakar A Nature communications 27725672 Nat Commun 2016 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/27725672
An automated microfluidic device for time-lapse imaging of mouse embryonic stem cells. Laing AF, Tirumala V, Hegarty E, Mondal S, Zhao P, Hamilton WB, Brickman JM, Ben-Yakar A Biomicrofluidics 31558920 Biomicrofluidics 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31558920
Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene egl-1 in a Living Neuron Pair in Caenorhabditis elegans. Cohn J, Dwivedi V, Valperga G, Zarate N, de Bono M, Horvitz HR, Pierce JT G3 (Bethesda, Md.) 31519744 G3 (Bethesda) 2019 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/31519744
Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. Yi B, Sahn JJ, Ardestani PM, Evans AK, Scott LL, Chan JZ, Iyer S, Crisp A, Zuniga G, Pierce JT, Martin SF, Shamloo M Journal of neurochemistry 27926996 J Neurochem 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27926996
Planar Laser Activated Neuronal Scanning (PLANS) System for in vivo Flow Cytometry. Watson N, Mondal S, DuPlissis A, Kim KH, Ben-Yakar A Frontiers in optics. Annual Meeting of the Optical Society of America 35350105 Front Opt 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/35350105
Ultrafast laser nanosurgery in microfluidics for genome-wide screenings. Ben-Yakar A, Bourgeois F Current opinion in biotechnology 19278850 Curr Opin Biotechnol 2009 Feb https://www.ncbi.nlm.nih.gov/pubmed/19278850
Small-molecule-mediated axonal branching in Caenorhabditis elegans. Zlotkowski K, Pierce-Shimomura J, Siegel D Chembiochem : a European journal of chemical biology 23362121 Chembiochem 2013 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/23362121
Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans. Nordquist SK, Smith SR, Pierce JT G3 (Bethesda, Md.) 29367452 G3 (Bethesda) 2018 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/29367452
A multi-trap microfluidic chip enabling longitudinal studies of nerve regeneration in Caenorhabditis elegans. Gokce SK, Hegarty EM, Mondal S, Zhao P, Ghorashian N, Hilliard MA, Ben-Yakar A Scientific reports 28852096 Sci Rep 2017 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/28852096
Magnetosensitive neurons mediate geomagnetic orientation in Caenorhabditis elegans. Vidal-Gadea A, Ward K, Beron C, Ghorashian N, Gokce S, Russell J, Truong N, Parikh A, Gadea O, Ben-Yakar A, Pierce-Shimomura J eLife 26083711 Elife 2015 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/26083711
APP-Induced Patterned Neurodegeneration Is Exacerbated by APOE4 in Caenorhabditis elegans. Sae-Lee W, Scott LL, Brose L, Encarnacion AJ, Shi T, Kore P, Oyibo LO, Ye C, Rozmiarek SK, Pierce JT G3 (Bethesda, Md.) 32580938 G3 (Bethesda) 2020 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/32580938
Femtosecond laser nanoaxotomy properties and their effect on axonal recovery in C. elegans. Bourgeois F, Ben-Yakar A Optics express 18725955 Opt Express 2008 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/18725955
Worming our way to Alzheimer's disease drug discovery. Iyer S, Pierce-Shimomura JT Biological psychiatry 23399470 Biol Psychiatry 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23399470
High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model. Mondal S, Hegarty E, Sahn JJ, Scott LL, Gökçe SK, Martin C, Ghorashian N, Satarasinghe PN, Iyer S, Sae-Lee W, Hodges TR, Pierce JT, Martin SF, Ben-Yakar A ACS chemical neuroscience 29426225 ACS Chem Neurosci 2018 May 16 https://www.ncbi.nlm.nih.gov/pubmed/29426225
Line excitation array detection fluorescence microscopy at 0.8 million frames per second. Martin C, Li T, Hegarty E, Zhao P, Mondal S, Ben-Yakar A Nature communications 30374138 Nat Commun 2018 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/30374138
Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. Cohn JA, Cebul ER, Valperga G, Brose L, de Bono M, Heiman MG, Pierce JT Developmental biology 31945343 Dev Biol 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/31945343

This page last reviewed on April 13, 2026