4DN Investigator Spotlight: Jennifer Phillips-Cremins
Dr. Jennifer Phillips-Cremins is an Assistant Professor at the University of Pennsylvania. She researches the brain and how neurons (nerve cells) in…
Scientists Develop Molecular Tweezers with CRISPR-GO
One of the goals of the 4D Nucleome (4DN) program is to understand how organization of all the DNA in the nucleus – called the genome – affects cell…
3D Mapping Strategy Reveals Framework for Gene Expression
Chromatin is a complex of genomic DNA and proteins that make up the chromosomes within the nucleus of a cell. The organization of genomic material…
Making the Nucleus Measure Up
The dynamic 3D organization of DNA in the tiny nucleus of a cell plays a critical role in determining which genes are turned on in a cell (gene…
New Tools to Study Cellular Phase Separation
4D Nucleome program-funded investigator Dr. Clifford Brangwynne and his team have developed two new tools to study and control cellular phase…
Misfolded DNA Contributes to Neurodegenerative Disease
Over 1% of our DNA is made up of repeated sequences, which equals tens of thousands of short repeat tracts.
Turning on Genes is No Lonely Job
At any given time, only some of the genes in our DNA are turned on, or “active,” while others are turned off. Making sure only the correct genes are…
New Technique for 3D Genome Mapping
The 3D organization of DNA in the nucleus of a cell plays an important role in determining which genes are turned on in that cell. This has important…
Viewing the Moment a Gene Turns On
Genes are the segments of our DNA that code for proteins that determine our traits. Over 90% of our DNA does not encode genes and was long considered…
Packaging Chromosomes for Cell Division
Determine how the structure of DNA in the nucleus of a cell changes over time
This page last reviewed on October 31, 2023
