TCPA Awards

2017 TCPA Awardees

Ten researchers received the Transformative Collaborative Project Award (TCPA) to build trans- or interdisciplinary teams that will pursue novel research or develop new tools and technologies to support the 4DN mission and further enhance international collaboration.

Funded by National Institutes of Health

Elucidating the role of nascent RNA in enhancer-promoter communication and three-dimensional genome organization
PI: Karen Adelman, Co-PI: Joanna Wysocka
Harvard Medical School

Establishing the 3D chromatin architectural organization of the zebrafish embryonic genome
PI: Brad Cairns, Co-PI: Antonio Giraldez
University of Utah

Multi-Contact Conformation Capture: uncovering regulatory hubs and mutually exclusive topologies
PI: Wouter de Laat, Co-PI: Jeroen de Ridder
Hubrecht Institute, Netherlands

Tethered nuclease strategies for in situ mapping of 3D nuclear organization
PI: Steve Henikoff, Co-PIs: Kamran Ahmad, Jay Shendure, William Noble
Fred Hutchinson Cancer Research Center

Inference and Validation of Chromosomes 3D Structure via Statistical Shape Analysis of Elastic Curves Models
PI: Nicola Neretti, Co-PIs: Anuj Srivastava, Chao-Ting Wu
Brown University

The Cell Nucleus under Stress
PI: Karla Neugebauer, Co-PI: Joan Steitz
Yale University

Dynamic 3D folding of the mammalian genome: molecular determinants and impact on gene expression in vivo
PI: Francois Spitz, Co-PIs: Leonid Mirny, Thomas Gregor
Institute Pasteur, Paris, France

Development of TrAC-loop, a novel technique to detect genome-wide chromatin interactions
PI: Keji Zhao, Co-PIs: Gangqing Hu, Binbin Lai, Qingsong Tang
National Heart, Lung, and Blood Institute

Funded by Canadian Institutes of Health Research 

Accessing chromatin interactions by high-resolution analyses of correlated regulatory element variation PI: Tomi Pastinen, Co-PIs: Elin Grundberg, Guillaume Bourque
McGill University

Spatiotemporal dynamics of chromatin: the circadian and aging connection PI: Arturas Petronis, Co-PI: Ting Wang
Centre for Addiction and Mental Health, Canada