4D Nucleome (4DN)
4D Nucleome (4DN)
Funded Research
| PI Name | Institution Name | Title |
|---|---|---|
| DEKKER, JOB (contact) MIRNY, LEONID A | UNIV OF MASSACHUSETTS MED SCH WORCESTER | Center for 3D Structure and Physics of the Genome |
| MA, JIAN (contact) ALBER, FRANK BELMONT, ANDREW STEVEN WU, CHAO-TING | CARNEGIE-MELLON UNIVERSITY | Multiscale Analyses of 4D Nucleome Structure and Function by Comprehensive Multimodal Data Integration |
| NOBLE, WILLIAM STAFFORD (contact) DISTECHE, CHRISTINE M. SHENDURE, JAY ASHOK | UNIVERSITY OF WASHINGTON | UW 4-Dimensional Genomic Organization of Mammalian Embryogenesis Center |
| REN, BING (contact) DULAC, CATHERINE G LEIN, ED NICODEMI, MARIO POMBO, ANA WANG, TING ZHUANG, XIAOWEI | UNIVERSITY OF CALIFORNIA, SAN DIEGO | Center for Integrated Multi-modal and Multi-scale Nucleome Research |
| PI Name | Institution Name | Title |
|---|---|---|
| DIAO, YARUI | DUKE UNIVERSITY | The 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repair |
| KALHOR, REZA | JOHNS HOPKINS UNIVERSITY | Dynamics of lineage-specific genome reorganization in gastrulation and their response to disease-associated epigenetic perturbations |
| LI, WENBO | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON | Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome Organization |
| SATPATHY, ANSUMAN | STANFORD UNIVERSITY | 4DN Interrogation of T Cell Exhaustion in Cancer |
| YAMADA, TOMOKO | NORTHWESTERN UNIVERSITY | Mechanisms of Genome Organization in Brain Development and Behavior |
| ZHANG, HUAIYING | CARNEGIE-MELLON UNIVERSITY | Phase separation-induced nuclear organization in ALT Cancer |
| PI Name | Institution Name | Title |
|---|---|---|
| ZHONG, SHENG | UNIVERSITY OF CALIFORNIA, SAN DIEGO | The second phase of NIH Common Fund 4D Nucleome Network Organizational Hub |
| PI Name | Institution Name | Title |
|---|---|---|
| PARK, PETER J | HARVARD MEDICAL SCHOOL | 4D Nucleome Network Data Coordination and Integration Center |
| PI Name | Institution Name | Title |
|---|---|---|
| JARVIS, THALE CROSS | KEYSTONE SYMPOSIA | 3D Genome: Gene Regulation and Disease |
| PI Name | Institution Name | Title |
|---|---|---|
| ALBER, FRANK (contact) CHEN, LIN | UNIVERSITY OF SOUTHERN CALIFORNIA | Mapping the 3D Genome Landscape |
| BELMONT, ANDREW STEVEN | UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN | Combined Cytological, Genomic, and Functional Mapping of Nuclear Genome Organization |
| DEKKER, JOB (contact) MIRNY, LEONID A | UNIV OF MASSACHUSETTS MED SCH WORCESTER | Center for 3D Structure and Physics of the Genome |
| REN, BING (contact) MURRE, CORNELIS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD | San Diego Center for 4D Nucleome Research |
| RUAN, YIJUN | JACKSON LABORATORY | Nucleome Positioning System for Spatiotemporal Genome Organization and Regulation |
| SHENDURE, JAY ASHOK (contact) NOBLE, WILLIAM STAFFORD | UNIVERSITY OF WASHINGTON | University of Washington Center for Nuclear Organization and Function |
| PI Name | Institution Name | Title |
|---|---|---|
| PARK, PETER J | HARVARD MEDICAL SCHOOL | 4D Nucleome Network Data Coordination and Integration Center |
| WANG, TING (contact) | WASHINGTON UNIVERSITY | The WashU 4DN Network Data Coordination and Integration Center |
| PI Name | Institution Name | Title |
|---|---|---|
| ZHONG, SHENG (contact) CHIEN, SHU REN, BING SUBRAMANIAM, SHANKAR | UNIVERSITY OF CALIFORNIA SAN DIEGO | The Organizational Hub and Web Portal for the 4D Nucleome Network |
| PI Name | Institution Name | Title |
|---|---|---|
| BRANGWYNNE, CLIFFORD P | PRINCETON UNIVERSITY | Optogenetic Droplets: Using Light to Control Nucleoplasmic Phase Separation |
| GERACE, LARRY R. | SCRIPPS RESEARCH INSTITUTE | Mapping the organization of the peripheral nuclear compartment |
| GROUDINE, MARK T | FRED HUTCHINSON CANCER RES CENTER | A toolkit to reversibly disrupt nuclear bodies and move genes among compartments |
| GUTTMAN, MITCHELL (contact) HESS, SONJA RINN, JOHN LOUIS | CALIFORNIA INSTITUTE OF TECHNOLOGY | Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartments |
| KAUFMAN, PAUL D. (contact) DEKKER, JOB PEDERSON, THORU | UNIV OF MASSACHUSETTS MED SCH WORCESTER | Nucleolar Genomics During Early Mammalian Development |
| LOMVARDAS, STAVROS (contact) BROWN, LEWIS M. | COLUMBIA UNIVERSITY HEALTH SCIENCES | Deciphering nuclear bodies and compartments that govern singular olfactory receptor expression |
| PI Name | Institution Name | Title |
|---|---|---|
| FRASER, PETER J (contact) TANAY, AMOS | THE BABRAHAM INSTITUTE | New automated experimental and computational pipeline for high coverage single-cell Hi-C and its integration with single cell RNA-seq: enabling 4D Nucleomics at single cell resolution |
| GUTTMAN, MITCHELL (contact) ISMAGILOV, RUSTEM F | CALIFORNIA INSTITUTE OF TECHNOLOGY | Novel tools to comprehensively map dynamic organization of RNA and DNA in higher-order nuclear structures within single cells |
| LIEBERMAN-AIDEN, EREZ | BAYLOR COLLEGE OF MEDICINE | Beyond pairwise DNA contacts: exploring higher-order genome structure using proximity ligation and split pool barcoding |
| LIS, JOHN T (contact) LIN, HENING ZIPFEL, WARREN R | CORNELL UNIVERSITY | Distance-Hi-C: Creating Photo Activated X-linkers To Define Nuclear Architecture |
RAJ, ARJUN (contact) PHILLIPS-CREMINS, JENNIFER | UNIVERSITY OF PENNSYLVANIA | Engineering and visualizing genome folding at high spatiotemporal resolution |
