Funded Research

Nuclear Organization and Function Interdisciplinary Consortium (NOFIC) (U54) RFA-RM-14-030
PI Name Institution Name Title
ALBER, FRANK (contact) 
CHEN, LIN
UNIVERSITY OF SOUTHERN CALIFORNIA Mapping the 3D Genome Landscape
BELMONT, ANDREW STEVEN UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN Combined Cytological, Genomic, and Functional Mapping of Nuclear Genome Organization
DEKKER, JOB (contact) 
MIRNY, LEONID A
UNIV OF MASSACHUSETTS MED SCH WORCESTER Center for 3D Structure and Physics of the Genome
REN, BING (contact) 
MURRE, CORNELIS
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD San Diego Center for 4D Nucleome Research
RUAN, YIJUN JACKSON LABORATORY Nucleome Positioning System for Spatiotemporal Genome Organization and Regulation
SHENDURE, JAY ASHOK (contact) 
NOBLE, WILLIAM STAFFORD
UNIVERSITY OF WASHINGTON University of Washington Center for Nuclear Organization and Function

 

4D Nucleome Imaging Tools (U01) RFA-RM-14-009
PI Name Institution Name Title
BEWERSDORF, JOERG (contact) 
BADDELEY, DAVID
YALE UNIVERSITY An Integrated Imaging System for High-throughput Nanoscopy of the 4D Nucleome
CAI, LONG (contact) 
QI, LEI STANLEY
CALIFORNIA INSTITUTE OF TECHNOLOGY Hi-resolution dynamic imaging of chromosomes in single cells by combined CRISPR imaging and sequential FISH
ELLENBERG, JAN EUROPEAN MOLECULAR BIOLOGY LABORATORY Reconstructing the dynamic 3D architecture of the human genome by superresolution microscopy and DNA sequence modelling
GREGOR, THOMAS (contact) 
LEVINE, MICHAEL S.
PRINCETON UNIVERSITY Imaging chromosome dynamics and measuring its impact on transcriptional activity
GRUNWALD, DAVID UNIV OF MASSACHUSETTS MED SCH WORCESTER Visualizing local and global chromatin architecture, and gene expression in the individual cell by structural (SUSHI) and temporal (3D-SMRT) single molecule imaging
LAM, KIT S (contact) 
CHENG, R.HOLLAND  
IZUMIYA, YOSHIHIRO 
UNIVERSITY OF CALIFORNIA AT DAVIS Genetically Encoded Small Illuminants for 4D nucleome imaging
LIPHARDT, JAN T. STANFORD UNIVERSITY Deep Super-localization Microscopy and Effectively Unbleachable Labeling for 4D Nucleomics
O'SHEA, CLODAGH (contact) 
ELLISMAN, MARK H 
SALK INSTITUTE FOR BIOLOGICAL STUDIES Imaging local and global chromatin structure as a 3D continuum within the nucleus
SINGER, ROBERT H. (contact) 
DARZACQ, XAVIER 
ALBERT EINSTEIN COLLEGE OF MEDICINE Tools For Imaging the Functional Genome in Living Cells and Tissues

 

4D Nucleome Network Data Coordination and Integration Center (U01) RFA-RM-14-011
PI Name Institution Name Title
PARK, PETER J HARVARD MEDICAL SCHOOL 4D Nucleome Network Data Coordination and Integration Center
WANG, TING (contact)  WASHINGTON UNIVERSITY The WashU 4DN Network Data Coordination and Integration Center

 

4D Nucleome Network Organizational Hub (U01) RFA-RM-14-010
PI Name Institution Name Title
ZHONG, SHENG (contact) 
CHIEN, SHU  
REN, BING  
SUBRAMANIAM, SHANKAR
UNIVERSITY OF CALIFORNIA SAN DIEGO The Organizational Hub and Web Portal for the 4D Nucleome Network

 

Study of Nuclear Bodies and Compartments (U01) RFA-RM-14-008
PI Name Institution Name Title
BRANGWYNNE, CLIFFORD P PRINCETON UNIVERSITY Optogenetic Droplets: Using Light to Control Nucleoplasmic Phase Separation
GERACE, LARRY R. SCRIPPS RESEARCH INSTITUTE Mapping the organization of the peripheral nuclear compartment
GROUDINE, MARK T FRED HUTCHINSON CANCER RES CENTER A toolkit to reversibly disrupt nuclear bodies and move genes among compartments
GUTTMAN, MITCHELL (contact) 
HESS, SONJA  
RINN, JOHN LOUIS
CALIFORNIA INSTITUTE OF TECHNOLOGY Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartments
KAUFMAN, PAUL D. (contact) 
DEKKER, JOB  
PEDERSON, THORU
UNIV OF MASSACHUSETTS MED SCH WORCESTER Nucleolar Genomics During Early Mammalian Development
LOMVARDAS, STAVROS (contact) 
BROWN, LEWIS M.
COLUMBIA UNIVERSITY HEALTH SCIENCES Deciphering nuclear bodies and compartments that govern singular olfactory receptor expression

 

Nucleomics Tools (U01) RFA-RM-14-007
PI Name Institution Name Title
FRASER, PETER J (contact) 
TANAY, AMOS      
THE BABRAHAM INSTITUTE New automated experimental and computational pipeline for high coverage single-cell Hi-C and its integration with single cell RNA-seq: enabling 4D Nucleomics at single cell resolution
GUTTMAN, MITCHELL (contact) 
ISMAGILOV, RUSTEM F
CALIFORNIA INSTITUTE OF TECHNOLOGY Novel tools to comprehensively map dynamic organization of RNA and DNA in higher-order nuclear structures within single cells
LIEBERMAN-AIDEN, EREZ BAYLOR COLLEGE OF MEDICINE Beyond pairwise DNA contacts: exploring higher-order genome structure using proximity ligation and split pool barcoding
LIS, JOHN T (contact) 
LIN, HENING  
ZIPFEL, WARREN R 
CORNELL UNIVERSITY Distance-Hi-C: Creating Photo Activated X-linkers To Define Nuclear Architecture

RAJ, ARJUN (contact) 
BLOBEL, GERD A 

PHILLIPS-CREMINS, JENNIFER

 

UNIVERSITY OF PENNSYLVANIA Engineering and visualizing genome folding at high spatiotemporal resolution

 

 

 

 

This page last reviewed on May 15, 2017