Program Snapshot

The goal of the Common Fund’s Structural Biology program was to develop novel methods to isolate large amounts of membrane proteins and determine their protein structures.

The program provided the following resources to the scientific community:

  • Laboratory Methods
  • Research Tools
  • Reference Materials
  • Database/Libraries

G Protein Coupled Receptor (GPCR)

G Protein Coupled Receptor (GPCR) structures solved to date through the Joint Center for Integral Membrane Protein Technologies-Complexes (JCIMPT-Complexes)

JCIMPT-Complexes

Click on the protein structure images to learn more!

In 2007, Common Fund support of pioneering methods in membrane protein production resulted in the determination of the structure of the β2 Adrenergic receptor. Since then, these methods and others have rapidly accelerated GPCR membrane protein structure determination, as shown above.

Why care about GPCRs?

S1P1 ReceptorImmune system, multiple sclerosisA2a AdenosineCardiovascular, respiratory, Parkinson's diseaseCXCR4 Chemokine recptorImmune system, HIV, cancerKappa opiodand Nociceptin FQ recptorsPain, mood, drig abuseD3 Dopamine recptorBrain signaling, schizophreniaH1 Histamine recptorImmune system allergies, inflamationAdrenergic recptorCardiovascular, asthma

This page last reviewed on May 8, 2017