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Program Snapshot

The goal of the Common Fund’s Structural Biology program was to develop novel methods to isolate large amounts of membrane proteins and determine their protein structures.

The program provided the following resources to the scientific community:

  • Laboratory Methods
  • Research Tools
  • Reference Materials
  • Database/Libraries

G Protein Coupled Receptor (GPCR)

G Protein Coupled Receptor (GPCR) structures solved to date through the Joint Center for Integral Membrane Protein Technologies-Complexes (JCIMPT-Complexes)


Click on the protein structure images to learn more!

In 2007, Common Fund support of pioneering methods in membrane protein production resulted in the determination of the structure of the β2 Adrenergic receptor. Since then, these methods and others have rapidly accelerated GPCR membrane protein structure determination, as shown above.

Why care about GPCRs?

S1P1 Receptor Immune system, multiple sclerosis A2a Adenosine Cardiovascular, respiratory, Parkinson's disease CXCR4 Chemokine recptor Immune system, HIV, cancer Kappa opiodand Nociceptin FQ recptors Pain, mood, drig abuse D3 Dopamine recptor Brain signaling, schizophrenia H1 Histamine recptor Immune system allergies, inflamation Adrenergic recptor Cardiovascular, asthma


The Structural Biology program has transitioned from Common Fund support. Common Fund programs are strategic investments that aim to achieve a set of high impact goals within a 5-10 year timeframe. At the conclusion of each program, deliverables transition to other sources of support or use within the scientific community.

The Structural Biology program was supported by the Common Fund FY2004 through FY2013. Efforts in the area of structural biology will continue via various other means of funding outside of the Common Fund.

This page last reviewed on March 22, 2024