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Funded Research

2014 NIH Director's New Innovator Award Program (DP2)
RFA-RM-13-007
PI Name Institution Name Title
ABATE, ADAM R.

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Microfluidic Immunoprofiling for Biomarker Discovery in Rheumatoid Arthritis

 

ACAR, MURA​

 

YALE UNIVERSITY

 

Quantitative Real-Time Characterization of Single-Cell Aging: From Phenotypes to

 

ANDE, SATYANARAYANA​

 

GEORGIA REGENTS UNIVERSITY CANCER CENTER

 

A Multifaceted Approach to Target Obesity

 

ANDERMANN, MARK L

 

BETH ISRAEL DEACONESS MEDICAL CENTER

 

Multiphoton Imaging of Thoughts of Food During Natural and Induced Hunger States

 

ANTHONY, ROBERT MCCULLOUGH

 

HARVARD MEDICAL SCHOOL

 

Glycoengineering In Vivo

 

ARDEHALI, REZA

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Exploring Heterogeneity of Cardiac Fibroblasts to Reverse Fibrosis

 

ARORA, MANISH

 

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

 

Reconstructing Fetal Toxicant Exposure and Homeostatic Disruptions

 

AYE, YIMON

 

CORNELL UNIVERSITY

 

Deconvoluting Redox Biology with Targeted Chemistry

 

BASSIK, MICHAEL C

 

STANFORD UNIVERSITY

 

Accelerating Drug Development and Repurposing Using Systematic Genetic Interaction Maps in Mammalian Cells

 

BONASIO, ROBERTO

 

UNIVERSITY OF PENNSYLVANIA

 

Studying Epigenetic Pathways in Brain Function and Social Behavior Using Ants

 

BORAD, MITESH

 

MAYO CLINIC ARIZONA

 

Oncolytic Virotherapy in Hepatocellular Cancer

 

BUSCHMAN, TIMOTHY J.

 

PRINCETON UNIVERSITY

 

Developing an Adaptive Cognitive Prosthetic to Replace Damaged Brain Regions

 

CANG, HU

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Ultra Sensitive Single Molecule Spectroscopy with Plasmonic Antennas

 

CISSE, IBRAHIM

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Imaging Transcription with Single Molecule Resolution in Live Mammalian Cells

 

COBEY, SARAH

 

THE UNIVERSITY OF CHICAGO

 

Modeling the Evolutionary Dynamics of Immunity to Influenza for Vaccine Development

 

GARNER, ETHAN CLARK

 

HARVARD UNIVERSITY

 

Dissecting Bacterial Cell Wall Synthesis Using In Vivo Single Molecule Tracking

 

GLICKFELD, LINDSEY L

 

DUKE UNIVERSITY

 

Context-Dependent Changes in Local and Long-Range Cortical Circuits

 

GOODWIN, ANDREW P.

 

UNIVERSITY OF COLORADO

 

Rapid, Multiscale Sensing Using Acoustic Detection Mechanisms

 

HALLEM, ELISSA ANYON

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

The Neural Basis of Odor-Driven Behavior in Skin-Penetrating Parasitic Nematodes

 

HENDON, CHRISTINE P

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

High Resolution Imaging of the Myocardium

 

HUH, DONGEUN

 

UNIVERSITY OF PENNSYLVANIA

 

Probing the Physics of Chronic Lung Disease Using Microphysiological Biomimicry

 

INGOLIA, NICHOLAS T

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Molecular Basis and Cellular Roles of Translational Regulation

 

JANELSINS, MICHELLE C

 

UNIVERSITY OF ROCHESTER

 

Clinical and Translational Approaches to Cognitive Impairments in Cancer

 

KADOCH, CIGALL

 

DANA-FARBER CANCER INSTITUTE

 

Reversing Oncogenic BAF Complex Structure & Function: New Therapeutic Approaches

 

KOSURI, SRIRAM

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Reverse Genomics of Regulatory Elements Governing Splicing

 

KREEGER, PAMELA K

 

UNIVERSITY OF WISCONSIN-MADISON

 

Analysis of How Quantitative Cellular Network Variation Impacts Tumor Progression

 

LANDER, GABRIEL CEDRIC

 

THE SCRIPPS RESEARCH INSTITUTE

 

Molecular Basis of Axonal Transport Described by High-Resolution 3D Imaging

 

LIN, CHENXIANG

 

YALE UNIVERSITY

 

Cell-Free Membrane Remodeling Guided by DNA Nano-Templates

 

LIPOVICH, LEONARD

 

WAYNE STATE UNIVERSITY

 

Life, Death, and Function: The Primate-Specific Long Non-Coding RNA Transcriptome

 

MARTIN, BRENT RANDALL

 

UNIVERSITY OF MICHIGAN

 

Multiscale Chemical Approaches to Map Oxidative Stress

 

MCALPINE, MICHAEL

 

UNIVERSITY OF MINNESOTA

 

3D Printed Nano-Bionic Organs

 

MURTHY, MALA

 

PRINCETON UNIVERSITY

 

How Does the Brain Solve the Pattern Recognition Problem?

 

NEUERT, GREGOR

 

VANDERBILT UNIVERSITY

 

Decoding the Noncoding Genome: lncRNA Dynamics and Function in Single Cells

 

ROSENBLUM, MICHAEL DAVID

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Functional Manipulation of Memory Regulatory T cells in Skin

 

ROUND, JUNE LOUISE

 

UNIVERSITY OF UTAH

 

Developing Therapies to Target the Microbiota

 

SCHOGGINS, JOHN W.

 

UT SOUTHWESTERN MEDICAL CENTER

 

Discovery of Antiviral Mechanisms in Bats

 

SFEIR, AGNEL

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Telomere-Independent Strategies to Protect Chromosome Ends

 

SIMON, MATTHEW DAVID

 

YALE UNIVERSITY

 

Integrating RNAs into Signaling Pathways by Engineering Covalent RNA Modification

 

STABENFELDT, SARAH E

 

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

 

Detecting and Treating Traumatic Brain Injury Pathology Progression from the Insi

 

TAGA, MICHIKO E

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Targeted Killing of Bacteria in Communities

 

TIAN, LIN

 

UNIVERSITY OF CALIFORNIA AT DAVIS

 

Fluorescent Biosensors for Imaging Neurotransmitters: Observing Synapses in Action

 

WAN, LEO Q.

 

RENSSELAER POLYTECHNIC INSTITUTE

 

Cell Chirality Based In Vitro Models for Embryonic Development and Abnormalities

 

WESTREICH, DANIEL J

 

UNIV OF NORTH CAROLINA CHAPEL HILL

 

From Patients to Policy: Innovative Epidemiology for Implementation Science

 

XU, RONG

 

CASE WESTERN RESERVE UNIVERSITY

 

Rapid Reverse Translational Drug Repositioning

 

YANG, LEI

 

UNIVERSITY OF PITTSBURGH

 

Toward Regeneration of Whole Bioartificial Human Heart

 

YANG, LILI

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Stem Cell-Engineered Invariant Natural Killer T Cells for Cancer Therapy

 

ZHANG, LIJIE GRACE

 

GEORGE WASHINGTON UNIVERSITY

 

A Novel 3D Bioprinted Smart Vascularized Nano Tissue

 

ZHAO, WEIAN

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Mechano-Sensing Stem Cells to Study, Detect and Treat Cancer Metastases

 

ZONCU, ROBERTO

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Engineering Organelle Function to Rewire Cancer Cell Metabolism

 

ZONG, CHENGHANG

 

BAYLOR COLLEGE OF MEDICINE

 

Detecting the Onset of Genome Heterogeneity in Tumor at Single Cell Resolution

 

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2013 NIH Director’s New Innovator Award Program (DP2)
RFA-RM-12-016
PI Name Institution Name Title
ADESNIK, HILLEL

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

New Optical Strategies to Unlock the Neural Basis of Perception

 

AHERN, JENNIFER

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

A Rigorous System to Determine the Health Impacts of Policies and Programs

 

ALDRIDGE, BREE BEARDSLEY

 

TUFTS UNIVERSITY BOSTON

 

Quantitative Design of Multi-drug Regiments for Tuberculosis

 

ATON, SARA J

 

UNIVERSITY OF MICHIGAN

 

Linking Network Activity and Intracellular Plasticity Mechanisms During Sleep-Dep

 

BLISH, CATHERINE A

 

STANFORD UNIVERSITY

 

Harnessing Natural Killer Cell Memory to Fight Viruses

 

CRAWFORD, JASON MICHAEL

 

YALE UNIVERSITY

 

Cryptic Gut Bacterial Metabolites that Regulate Colorectal Cancer Formation

 

DAR, ARVIN

 

MOUNT SINAI SCHOOL OF MEDICINE

 

Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase

 

DEO, RAHUL CHANDRAKANT

 

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

 

Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies

 

DIEHN, MAXIMILIAN

 

STANFORD UNIVERSITY

 

Developing a Genomic Approach for Cancer Screening

 

DVORIN, JEFFREY D

 

CHILDREN'S HOSPITAL CORPORATION

 

Essential Gene Discovery in the Malaria Parasite Plasmodium falciparum

 

ESSER-KAHN, AARON PALMER

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Directing the Immune System via Polymeric Combinations of Molecular Signals

 

EVANS, SCOTT E

 

UT MD ANDERSON CANCER CTR

 

Inducible Epithelial Antiviral Resistance to Prevent Asthma

 

FIEDLER, DOROTHEA

 

PRINCETON UNIVERSITY

 

Understanding Phosphate Metabolism in Cancer and Metastasis

 

FROST, ADAM

 

UNIVERSITY OF UTAH

 

Toward Atomic Resolution of Membranes and Membrane-Associated Machines

 

GANDHI, SUNIL

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Rewiring Cortex Using Inhibitory Neuron Transplantation

 

GARTNER, ZEV JORDAN

 

UNIVERSITY OF CALIFORNIA-SAN FRANCISCO

 

Total Synthesis of the Human Mammary Gland

 

GRADINARU, VIVIANA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Neuromodulation and Neurodegeneration: The Missing Link and Mechanisms of Action

 

GREGG, ROBERT D

 

UNIVERSITY OF TEXAS DALLAS

 

Phase-Based Control of Locomotion for High-Performance Prostheses and Orthoses

 

HANSEN, SCOTT B

 

SCRIPPS FLORIDA

 

Molecular Mechanism of Mechanosensation

 

LAMB, TRACEY JANE

 

EMORY UNIVERSITY

 

The Development of Probiotic Yeast as an Inexpensive Vaccine Delivery Platform

 

LUCKS, JULIUS BEAU

 

CORNELL UNIVERSITY

 

A New High-Throughput Technology to Reveal the Dynamic Functional States of RNAs

 

MARR, LINSEY

 

VIRGINIA POLYTECHNIC INST AND ST UNIV

 

The Role of Pathogen-Environment Interactions in the Pandemic Potential of Influenza

 

MERRIKH, HOURA

 

UNIVERSITY OF WASHINGTON

 

Targeted Gene Evolution via Replication-Transcription Conflicts

 

MORTAZAVI, SEYED ALI

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Comparative Analysis of the 4D Encoding of Regulatory Networks in Stem Cells

 

O'CONNELL, RYAN

 

UNIVERSITY OF UTAH

 

Utilizing TALEN Technology to Regulate Human microRNAs

 

ONNELA, JUKKA-PEKKA

 

HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)

 

Using Mobile Phones for Social and Behavioral Sensing of Mood Disorder Patients

 

PETERSEN, CHRISTIAN

 

NORTHWESTERN UNIVERSITY

 

Regulatory Circuits Controlling Regenerative Growth

 

PEYTON, SHELLY R

 

UNIVERSITY OF MASSACHUSETTS AMHERST

 

Tissue-Specific Stem Cells and Breast Cancer Tissue Tropism

 

RUTA, VANESSA

 

ROCKEFELLER UNIVERSITY

 

Connecting Neural Plasticity to Learning and Memory

 

SAHIN, OZGUR

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Novel Sub-Cellular Chemical and Mechanical Nanoimaging

 

SANJABI, SHOMYSEH

 

J. DAVID GLADSTONE INSTITUTES

 

Characterizing HIV Latent Reservoir In Vivo

 

SATTELY, ELIZABETH SUSAN

 

STANFORD UNIVERSITY

 

Liberation of Plant Nutrients by the Gut Microbiota

 

SAVAGE, DAVID FRANK

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Fluorescent Biosensors for Metabolite Imaging in Live Cells

 

SEANDEL, MARCO

 

WEILL MEDICAL COLL OF CORNELL UNIV

 

Clonal Competition in Stem Cells as a Driver of Paternal Age Effect Diseases

 

SIVARAMAKRISHNAN, SIVARAJ

 

UNIVERSITY OF MICHIGAN

 

The Kinase Toolbox: Mapping the Spatial and Temporal Regulation of Cell Signaling

 

TAYLOR, DEREK JAMES

 

CASE WESTERN RESERVE UNIVERSITY

 

Induction of Cancer Cell Death by Selective DNA Misincorporation

 

TISCHLER, ANNA DEGRAFF

 

UNIVERSITY OF MINNESOTA

 

High-Throughput Identification of Mycobacterium tuberculosis Persistence Mechanism

 

TYE, KAY MAXINE

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits

 

WHITE, RICHARD MARK

 

SLOAN-KETTERING INST CAN RES

 

Evolutionary Dynamics of Melanoma Metastasis

 

WONG, WILSON

 

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

 

Synthetically Reengineered T cells as the Next Generation of Smart Cancer Therapy

 

ZHENG, YING

 

UNIVERSITY OF WASHINGTON

 

A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis

 

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2012 NIH Director’s New Innovator Award Program (DP2)
RFA-RM-11-005
PI Name Institution Name Title
ALLEN, CHRISTOPHER DAVID

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Cellular Interactions in Asthma

 

AUGUSTE, DEBRA

 

HARVARD UNIVERSITY

 

Personalized Therapeutics for Inhibiting Breast Cancer Metastasis

 

BALSKUS, EMILY PATRICIA

 

HARVARD UNIVERSITY

 

Biocompatible Chemistry for In Vivo Metabolite Modification

 

BIVONA, TREVER G

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Discovery of Rational Companion Therapeutic Targets to Optimize Cancer Treatment

 

BONKOWSKY, JOSH LEITCH

 

UNIVERSITY OF UTAH

 

Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon Reorganiz

 

BORENSTEIN, ELHANAN

 

UNIVERSITY OF WASHINGTON

 

A Computational Framework for Designing Microbiome Manipulation

 

BRANGWYNNE, CLIFFORD P

 

PRINCETON UNIVERSITY

 

Cell Growth Control by Cell and Organelle Size-Dependent Ribosome Biogenesis

 

CAMP, AMY HITCHCOCK

 

LEHIGH UNIVERSITY

 

A Feeding Tube Model for Bacterial Cell-Cell Communication

 

CARETTE, JAN EDUARD

 

STANFORD UNIVERSITY

 

Genetic Approaches to Discover Host Factors Critical to Dengue Virus Infection

 

CHEN, SHUIBING

 

WEILL MEDICAL COLLEGE OF CORNELL UNIV

 

Studying the Progression and Regression of Beta Cell Dysfunction in Type 2 Diabetes

 

CHI, PING

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

An Integrative Approach to Target Lineage-Specific Oncogenic Transcription Factor

 

CHURCHLAND, MARK

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

A Dynamical Systems Approach to Fundamental Questions in Neuroscience

 

CUI, BIANXIAO

 

STANFORD UNIVERSITY

 

Engineering External Forces for Manipulating Cargo Transport in Live Neurons

 

DANTAS, GAUTAM

 

WASHINGTON UNIVERSITY

 

Metagenomic Engineering of Probiotic Bacteria to Improve Intestinal Colonization

 

DONG, P. DUC SI

 

SANFORD-BURNHAM MEDICAL RESEARCH INSTIT

 

Unlocking Regenerative Potential through In Vivo Genetic Reprogramming

 

FALK, EMILY

 

UNIVERSITY OF PENNSYLVANIA

 

Can Neuroscience Dramatically Improve Our Ability to Design Health Communications

 

FEINBERG, ADAM WALTER

 

CARNEGIE-MELLON UNIVERSITY

 

Human Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds

 

GILL, HARVINDER SINGH

 

TEXAS TECH UNIVERSITY

 

Pollen Grains as Trojan Horses for Oral Vaccination

 

GOODMAN, ANDREW L

 

YALE UNIVERSITY

 

Defining the Contribution of Interpersonal Microbial Variation to Drug Metabolism

 

GORE, JEFF

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Early Warning Indicators of Tipping Points in Biological Systems

 

HAN, XUE

 

BOSTON UNIVERSITY

 

Light-Actuatable NanoRobots for Molecular Uncaging

 

HELLER, DANIEL ALAN

 

MEMORIAL SLOAN KETTERING CANCER CENTER

 

Transient Metabolite Detection for Single-Cell Metabolomics and Diagnostics

 

HIGGINS, JOHN MATTHEW

 

MASSACHUSETTS GENERAL HOSPITAL

 

Systems Biology of In Vivo Human Blood Cell Populations

 

JOHNSON, LAURA A

 

UNIVERSITY OF PENNSYLVANIA

 

Gene-Engineered Adoptive T Cell Immunotherapy of GBM

 

KOHLI, RAHUL MANU

 

UNIVERSITY OF PENNSYLVANIA

 

Combating Bacterial Drug Resistance by Targeting the Enzymes of Evolution

 

KRONAUER, DANIEL

 

ROCKEFELLER UNIVERSITY

 

Studying the Molecular Mechanisms of Social Life Using a Novel Ant Model System 

 

LILLEMEIER, BJOERN F.

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Decipher Membrane Patterns In Situ with Super-Resolution and Dynamic Microscopy

 

LIU, ALLEN PO-CHIH

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Building Artificial Platelets

 

LIU, WENDY

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Engineering Biomaterials to Exert Molecular Control of Immune Cell Function

 

MAIMON, GABY

 

ROCKEFELLER UNIVERSITY

 

Linking Genes to Higher Brain Function by Way of Cellular Electrophysiology

 

MARRAFFINI, LUCIANO A

 

ROCKEFELLER UNIVERSITY

 

Using CRISPR Immunity to Prevent the Spread of Virulence Traits Among Pathogens

 

MIN, WEI

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Label-Free Chemical Imaging for Biological Applications

 

MYONG, SUA

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

Quantitative Stepwise Analysis of RNA Interference

 

NIELL, CRISTOPHER

 

UNIVERSITY OF OREGON

 

Connecting Developmental Mechanisms to Visual Function and Perception

 

NIMMERJAHN, AXEL

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Novel Approaches to Study Microglia Physiology and Pathology in the Intact Brain

 

PERMAR, SALLIE R.

 

DUKE UNIVERSITY

 

Maternal Immune Protection Against Congenital CMV Infection

 

PERTSINIDIS, ALEXANDROS

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

Understanding Gene Transcription from First-Principles: A Single-Molecule Study

 

PRLIC, MARTIN

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

Paving the Way for a Novel Therapeutic Approach to Combat HIV

 

RODAL, AVITAL ADAH

 

BRANDEIS UNIVERSITY

 

Activity-Dependent Regulation of Membrane Traffic and Growth Signaling in Neurons

 

ROHATGI, RAJAT

 

STANFORD UNIVERSITY

 

Reconstructing Primary Cilia

 

SCHAEFER, ANNE

 

MOUNT SINAI SCHOOL OF MEDICINE

 

Cognate Microglia-Neuron Interaction and Its Role in Inflammation

 

SHU, XIAOKUN

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

New Principle-Based Technologies for Identifying Transient Protein Interactions

 

SOHAL, VIKAAS SINGH

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Reverse Engineering the Prefrontal Microcircuit

 

STOLTZ, DAVID A

 

UNIVERSITY OF IOWA

 

Airway Goblet Cells: Friend or Foe?

 

SU, MING

 

NORTHEASTERN UNIVERSITY

 

Enhanced Radiation Therapy with Nanoscale Frequency Modulators

 

URBAN, ALEXANDER ECKEHART

 

STANFORD UNIVERSITY

 

Genomic and Epigenomic Effects of Large CNV in Neurons from iPSC

 

WITTEN, ILANA

 

PRINCETON UNIVERSITY

 

Therapeutic Plasticity: A Novel Paradigm for Treating Addiction

 

WOODROW, KIM A.

 

UNIVERSITY OF WASHINGTON

 

Nanomaterials for Engineering Protection in the Genital Mucosa

 

YOO, ANDREW

 

WASHINGTON UNIVERSITY

 

Microrna and Neural Factor-Mediated Direct Reprogramming of Cell Fates

 

ZHENG, SIYANG

 

PENNSYLVANIA STATE UNIVERSITY-UNIV PARK

 

Integration of Flexible Micro Spring Array and High Throughput Microfluidics for Obtaining Clinical Relevant Information from Circulating Tumor Cells

 

ZOVEIN, ANN CAPELA

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Engineering Human Endothelium for Hematopoietic Stem Cell Production

 

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2011 NIH Director’s New Innovator Award Program (DP2)
RFA-RM-10-009
PI Name Institution Name Title
ALLER, STEPHEN G

 

UNIVERSITY OF ALABAMA AT BIRMINGHAM

 

Streamlined Structures of Human Integral Membrane Proteins at Atomic Resolution

 

BAKER, AARON BLAIR

 

UNIVERSITY OF TEXAS AUSTIN

 

Engineering Effective Revascularization Strategies for Ischemia in Disease States

 

BARNA, MARIA

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Specialized Ribosomes in Control of Gene Expression and Embryonic Development

 

BASU, UTTIYA

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Non-Coding RNA Engineers Antibody Diversity

 

BUCHLER, NICOLAS EMILE

 

DUKE UNIVERSITY

 

Rewiring the Yeast Brain: Redundancy and Interference in Genetic Networks

 

CAI, LONG

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Systems Biology in Single Cells by Super-Resolution Barcoding

 

CANMAN, JULIE C

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

IR-LAMP: Optigenetic Technology to Spatially Manipulate Protein Function In Vivo

 

CARLSON, ERIN ELIZABETH

 

UNIVERSITY OF MINNESOTA

 

Targeted Natural Product Diversification to Identify Novel Antibacterial Agents

 

CHANG, EDWARD

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Functional Architecture of Human Speech Motor Cortex

 

CHANG, JOHN T

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Understanding the Basis for Cellular Diversity During Adaptive Immunity

 

CHANG, MICHELLE C

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Discovery and Mechanistic Study of Fluorine Biochemistry

 

CHENG, WEI

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Single Cell with One Particle Entry (SCOPE) for Study of HIV Infection

 

CHRISTOFK, HEATHER RENEE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Regulation of the Warburg Effect in Cancer

 

FRASER, HUNTER B

 

STANFORD UNIVERSITY

 

Systematic Functional Annotation of Human Cis-Regulatory Genetic Variation

 

GERSBACH, CHARLES A

 

DUKE UNIVERSITY

 

Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming

 

GEURTS, ARON M

 

MEDICAL COLLEGE OF WISCONSIN

 

Advanced Genetic Engineering Technology Development

 

GIANNESCHI, NATHAN CLAUDE

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Programming Pharmacokinetics In Vivo via In Situ Switching of Nanoscale Particle

 

GOENTORO, LEA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Relative Perception in Wnt Signaling

 

HAMMOND, MING CHEN

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

A Chemical Biology Approach to Tagging RNAs in Live Cells

 

HAN, SONGI

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Probing Early Protein Aggregation Mechanisms and Their Relationship to Disease Ef

 

HUANG, BO

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Solving Macromolecular Complex Architecture In Situ by Super-Resolution Microscopy

 

HUG, CHRISTOPHER

 

CHILDREN'S HOSPITAL BOSTON

 

Macrophage Integrated and Targeted Yeast Therapeutics

 

JIANG, HONGRUI

 

UNIVERSITY OF WISCONSIN MADISON

 

Accommodative Contact Lens for Presbyopic Correction

 

KALANTRY, SUNDEEP

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Initiation of Epigenetic Transcriptional Regulation

 

KASKO, ANDREA MARIE

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Phototunable Biomaterials to Engineer Complex 3D Cell Microenvironments

 

KING, MEGAN C

 

YALE UNIVERSITY

 

The Role of Nuclear Architecture in Adaptation

 

KOSAK, STEVEN TODD

 

NORTHWESTERN UNIVERSITY

 

Self-Organization of the Human Genome

 

LAMICHHANE, GYANU

 

JOHNS HOPKINS UNIVERSITY

 

New Drug for Treatment of Chronic Bacterial Infection

 

LEE, SEOK-YONG

 

DUKE UNIVERSITY

 

Pharmacology and Biophysics of the Voltage-Gated Sodium Channel Nav1.7

 

LEE, SHAUN W

 

UNIVERSITY OF NOTRE DAME

 

Design and Use of Novel Bacteriocins

 

LIEBERMAN AIDEN, EREZ

 

BROAD INSTITUTE, INC.

 

Exploring How the Genome Folds Through Proximity Ligation and Sequencing

 

LU, TIMOTHY

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

High-Throughput Nanoscale Approaches to Studying and Inhibiting Amyloid Toxicity

 

MAVERAKIS, EMANUAL M

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Investigation and Development of New Therapeutic Avenues for Scleroderma

 

MITCHELL, DOUGLAS ALAN

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

A Common Denominator of Pathogenesis; A Rare Opportunity for Novel Therapeutic De

 

OTT, HARALD C

 

MASSACHUSETTS GENERAL HOSPITAL

 

Organ Engineering Based on Perfusion Decellularized Matrix

 

PADERA, TIMOTHY P.

 

MASSACHUSETTS GENERAL HOSPITAL

 

Characterizing Lymphatic Micrometastases: Prognostic and Therapeutic Implications

 

PAEGEL, BRIAN M

 

SCRIPPS FLORIDA

 

Evolving and Engineering New Protease Tools for Mass Spectrometry Proteomics

 

PETRASCHECK, MICHAEL

 

SCRIPPS RESEARCH INSTITUTE

 

Modulation of Sensory Perception to Treat Age Related Disease

 

QUEITSCH, CHRISTINE

 

UNIVERSITY OF WASHINGTON

 

Does Organismal Robustness Explain the Missing Heritability in Complex Diseases?

 

RAJ, ARJUN

 

UNIVERSITY OF PENNSYLVANIA

 

Comprehensive Spatial Picture of Transcription in the Nucleus

 

SCHLIEKER, CHRISTIAN DIRK

 

YALE UNIVERSITY

 

Deciphering Novel Protein Quality Control Pathways in the Nuclear Periphery

 

TOBIN, DAVID M

 

DUKE UNIVERSITY

 

Modulating Eicosanoids to Treat Tuberculosis: Personalized, Host-directed Therapy

 

WANG, CHIHHUNG JASON

 

BOSTON MEDICAL CENTER

 

Healthy Ideas Exchange

 

WEIBEL, DOUGLAS BENJAMIN

 

UNIVERSITY OF WISCONSIN MADISON

 

Revisiting the Bacterial Cell Wall as a Target for New Antibiotics

 

WINGERT, REBECCA ANN

 

UNIVERSITY OF NOTRE DAME

 

Identification of Kidney Regeneration Mechanisms Using the Zebrafish

 

WU, JOY Y

 

MASSACHUSETTS GENERAL HOSPITAL

 

In Vivo Reconstitution of the Hematopoietic Niche

 

XAVIER, JOAO

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

Engineering Microbial Social Interactions: Towards New Anti-Biofilm Therapies

 

ZHANG, QI

 

VANDERBILT UNIVERSITY

 

Explore Fundamental Aspects of Neurotransmission with Multifunctional Nanosensor

 

ZHONG, HAINING

 

OREGON HEALTH AND SCIENCE UNIVERSITY

 

Examining the Architecture of Synapses in Brain Tissue at Nanometer Resolution

 

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2010 NIH Director's New Innovator Award Program (DP2)
RFA-RM-09-011
PI Name Institution Name Title
AGAR, NATHALIE YR

 

BRIGHAM & WOMEN'S HOSPITAL

 

Real-Time Stereotactic Mass Spectrometry Tissue Analysis for Intraoperative Neuro

 

AGARWAL, RITESH

 

UNIVERSITY OF PENNSYLVANIA

 

Optoelectronic Nanowire Probes for Investigation of Intra-Cellular Processes

 

AMARO, ROMMIE E

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

A Structural Systems Biology Approach to Drug Discovery

 

ARAVIN, ALEXEI A

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Taming of Small RNA-Based Epigenetic Mechanisms

 

ARMANI, ANDREA MARTIN

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Ultrasensitive Nanolasers For Epigenetics Investigations

 

BAUTISTA, DIANA MICHELE

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

New Approaches to Identify Molecular Mechanisms of Touch and Pain in Mammals

 

CEGELSKI, LYNETTE S

 

STANFORD UNIVERSITY

 

Structure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm Formation

 

CHENG, JIANJUN

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates

 

CHANG, EDWARD

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Functional Architecture of Human Speech Motor Cortex

 

CHI, NEIL C

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Directed Cardiac Cellular Programming: A New Paradigm for Cardiac Regeneration

 

COHEN, ADAM EZRA

 

HARVARD UNIVERSITY

 

Optical Sensing of Voltage, pH, and Small Molecules Using Microbial Rhodopsins

 

DAI, CHENGKAI

 

JACKSON LABORATORY

 

Role of a Novel Stress Response Mechanism-Genetic Buffering-in Tumor Evolution

 

DATTA, SANDEEP R

 

HARVARD UNIVERSITY (MEDICAL SCHOOL)

 

Revealing Fear: New Methods to Study Neural Circuits, Behavior and Disease

 

DI CARLO, DINO

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Engineering the Intracellular Micro- and Nanoenvironment

 

DUNN, ALEXANDER R

 

STANFORD UNIVERSITY

 

Uncovering New Roles for Mechanical Force in Tissue Development and Remodeling

 

EVANS, CONOR LEE

 

MASSACHUSETTS GENERAL HOSPITAL

 

Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer

 

FELDMAN, BRIAN J

 

STANFORD UNIVERSITY

 

Using Components of the Circadian Clock to Regulate Stem Cell Fate Decisions

 

FISCHBACH, MICHAEL ANDREW

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Identifying and Characterizing Small Molecules from the Human Microbiome

 

FELIPPE, MARIA JULIA B. F.

 

CORNELL UNIVERSITY ITHACA

 

Epigenetics: A Novel Approach in Primary Immunodeficiencies

 

GARCIA, BENJAMIN A

 

UNIVERSITY OF PENNSYLVANIA

 

Novel Methodology for Quantitative High-Throughput Cancer Epigenetics

 

GUERRERO, THOMAS M

 

WILLIAM BEAUMONT HOSPITAL RESEARCH INSTITUTE

 

Spatially Accurate Deformable Image Registration for Thoracic CT Application

 

GUZMAN, MONICA L

 

WEILL MEDICAL COLLEGE OF CORNELL UNIV

 

Selection of Novel Therapies to Ablate Chemoresistant Myeloid Leukemia Stem Cell

 

HERR, AMY ELIZABETH

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Towards High Throughput Proteomics: A Micro/Nanofluidic Framework for Blotless W

 

HOTOPP, JULIE

 

UNIVERSITY OF MARYLAND BALTIMORE

 

Impact of Bacterial-Animal Lateral Gene Transfer on Human Health

 

HUANG, TONY JUN

 

PENNSYLVANIA STATE UNIVERSITY-UNIV PARK

 

On-Chip Optofluidic Laser Scanning Confocal Microscope for Early Cancer Detection

 

HUANG, YU

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Graphene Nanostructures as a New Platform for Ultrasensitive Multiplexed Biologic

 

KHINE, MICHELLE

 

UNIVERSITY OF CALIFORNIA IRVINE

 

Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)

 

KLEIN, OPHIR D

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

An Evolutionary-Developmental Approach to Stem Cells Using Teeth as a Mode

 

KRITZER, JOSHUA A

 

TUFTS UNIVERSITY MEDFORD

 

Drugging the Undruggable: Targeting Transcription Factors with Small Cyclic Pept

 

LAIRD, DIANA J

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Cell Competition in the Developing Mouse Germline

 

LAVIK, ERIN

 

CASE WESTERN RESERVE UNIVERSITY

 

Clinically Translatable Nanotechnology: Hemostasis and Neuroprotection

 

LEE, JIN HYUNG

 

STANFORD UNIVERSITY

 

In Vivo Control and Functional Visualization of Stem Cell-Driven CNS Regeneration

 

LEVY, HARA

 

NORTHWESTERN UNIVERSITY FEINBERG SCHOOL OF MEDICINE AND ANN AND ROBERT H. LURIE CHILDREN’S HOSPITAL

 

Integration of Genomics with Genetics - Molecular Phenotypes for CF Lung Disease

 

LEY, RUTH EMILY

 

CORNELL UNIVERSITY ITHACA

 

Development of Immunization Strategies to Reshape Pathogenic Microbiomes

 

LUO, MINKUI

 

SLOAN-KETTERING INSTITUTE FOR CANCER RES

 

Enzyme-Engineering Approaches to Dissect Protein Methylation Profiles

 

MAJOR, MICHAEL BENJAMIN

 

UNIVERSITY OF NORTH CAROLINA CHAPEL HILL

 

Exploitation of Near-Haploid Human Cells for Functional Gene Discovery

 

MARCH, JOHN C

 

CORNELL UNIVERSITY ITHACA

 

Engineering Commensal Bacteria as Therapeutic Signal Mediators

 

NELSON, TIMOTHY J

 

MAYO CLINIC COLL OF MEDICINE, ROCHESTER

 

Dysfunctional Regeneration in Cardiomyopathy: Ips-Based Diagnosis and Therapy

 

NICULESCU, ALEXANDER B

 

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

 

Developing Blood Tests for Mood Disorders

 

NILES, JACQUIN C

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Engineered Regulated RNA Localization and Transport in Biological Systems

 

NOLAN, ELIZABETH M

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Antibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology

 

PLATT, MANU O

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Multiscale, Mechanistic, and Predictive Models of Stroke in Sickle Cell Disease

 

SEALE, PATRICK

 

UNIVERSITY OF PENNSYLVANIA

 

Molecular Regulation of Brown Adipose Cell Fate in Somitic Stem Cells

 

SITHARAMAN, BALAJI

 

STATE UNIVERSITY NEW YORK STONY BROOK

 

Nanotechnology-Based Theranostic Technology for Bone Tissue Engineering

 

THEOGARAJAN, LUKE SATISH KUMAR

 

UNIVERSITY OF CALIFORNIA SANTA BARBARA

 

Bio-Ionic Neural Interfaces

 

TUCKER, BUDD ALBERT

 

SCHEPENS EYE RESEARCH INSTITUTE

 

Development of a Cell Replacement Therapy to Treat Retinal Degenerative Blindness

 

WADE, JOSEPH THOMAS

 

WADSWORTH CENTER

 

Pervasive Transcription in Bacterial Genomes

 

WEISS, LAUREN ANNE

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Dissecting Epistasis and Pleiotropy in Autism Towards Personalized Medicine

 

WONG, PAK KIN

 

UNIVERSITY OF ARIZONA

 

Mechanoregulation of Tissue Morphogenesis

 

YANG, CHANGHUEI

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Applications of Time-Reverse Tissue Turbidity Suppression to Improve Biophotonics

 

YIN, PENG

 

HARVARD UNIVERSITY (MEDICAL SCHOOL)

 

Engineering Bioimaging Probes Based on Triggered Molecular Geometry

 

ZHAO, XILIN

 

UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL

 

Anaerobic Shock as a Novel Treatment for Tuberculosis

 

ZHONG, SHENG

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Evolutionary Models for Gene Regulatory Networks

 

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2009 NIH Director's New Innovator Award Program (DP2)
RFA-RM 09-003
PI Name Institution Name Title
ALBERS, MARK W

 

MASSACHUSETTS GENERAL HOSPITAL

 

The Olfactory Neural Circuit as a Systems Level Model of Neurodegenerative Disease

 

ALMUTAIRI, ADAH

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Chemically Amplified Response Strategies for Medical Sciences; Concepts Borrowed

 

ASHLEY, EUAN A

 

STANFORD UNIVERSITY

 

Nanoscale Approaches to Allelic Silencing In Myocardial Disease States

 

BAGNAT, MICHEL

 

DUKE UNIVERSITY

 

Discovering New Regulators of Cftr And Fluid Secretion In Zebrafish

 

BALAZSI, GABOR

 

UNIVERSITY OF TEXAS MD ANDERSON CAN CTR

 

Connecting the Selection of Noisy Gene Expression Deviants to Genetic Evolution

 

BANERJEE, IPSITA

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Defining Mechanisms Controlling Stem Cell Fate During DifferentiationARRA Logo

 

BROWN, EDWARD BERNARD

 

UNIVERSITY OF ROCHESTER

 

Exploiting Collagen Organization to Predict and Prevent Tumor Metastasis

 

CAMARGO, FERNANDO

 

CHILDREN'S HOSPITAL BOSTON

 

Analysis of Stem Cell Dynamics and Differentiation by Cellular BarcodingARRA Logo

 

CHRONIS, NIKOLAOS

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

A Biochip for Point-of-Care HIV/AIDS Diagnosis in the Developing WorldARRA Logo

 

COHEN THEODORE H

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Prevalence, Risk Factors and Consequences of Complex M. tuberculosis Infections

 

DERIEMER, KATHRYN

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Transmission and Virulence of Mycobacterium Tuberculosis

 

DIAZ, ELVA D

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Generation of Tumor Stem Cell Lines for Directed Therapeutics of Brain Cancer

 

ENGLER, ADAM JEFFREY

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Smart' Materials to Engineer a More Complete Stem Cell Niche

 

GRISHOK, ALLA

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Investigating the Potential of Endogenous RNAi in Mediating Adaptation to Environ

 

HALL, IRA M

 

UNIVERSITY OF VIRGINIA CHARLOTTESVILLE

 

Extent, Origin, and Control of Structural Variation in Mammalian Genomes

 

HEILSHORN, SARAH C

 

STANFORD UNIVERSITY

 

Engineering 3D In Vitro Niches to Reveal Fundamentals of Cellular Biomechanics

 

HUANG KERWYN CASEY

 

STANFORD UNIVERSITY

 

Engineering of Cell Shape and Intracellular Organization

 

JAIN, SANJAY

 

JOHNS HOPKINS UNIVERSITY

 

Novel Imaging Biomarkers to Address Fundamental Controversies in Tb Pathogenesis

 

JANES, KEVIN A.

 

UNIVERSITY OF VIRGINIA CHARLOTTESVILLE

 

Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein

 

KEMP, MELISSA LAMBETH

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Redox Regulation of Cellular Information Processing

 

KREIMAN, GABRIEL

 

CHILDREN'S HOSPITAL BOSTON

 

Towards the Neuronal Correlates of Visual Awareness

 

KRISTICH, CHRISTOPHER J

 

MEDICAL COLLEGE OF WISCONSIN

 

Genetic Approaches to Protein-Protein Interactions Mediating Antibiotic Resistance

 

KURDISTANI, SIAVASH

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

A Blueprint for Oncogenic Epigenetic Reprogramming

 

KWATE, NAA OYO A

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Immunologic Effects and a Structural "Countermarketing" Intervention: Racism, the

 

LEE, KIBUM

 

RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

 

Combinatorial Approaches for Studying Multiple Cues Regulating Human Pluripotent

 

LIM, DANIEL A

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Chromatin-Based Cellular Memory in Neural Stem Cells

 

LOMVARDAS, STAVROS

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Characterization of the Role of Cpa Methylation in Neuronal Plasticity

 

MACHADO, ANDRE GUELMAN

 

CLEVELAND CLINIC LERNER COL/MED-CWRU

 

Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for M

 

MASOPUST, DAVID

 

UNIVERSITY OF MINNESOTA TWIN CITIES

 

Maximizing Cd8 T Cells for Protection

 

MORA, JORGE RODRIGO

 

MASSACHUSETTS GENERAL HOSPITAL

 

Reassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication

 

MUOTRI, ALYSSON R

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Modeling Autism with Human Pluripotent Cells

 

NAGRATH, SUNITHA

 

MASSACHUSETTS GENERAL HOSPITAL

 

Engineering Sensitive Microfluidic Multiplex Technology for Isolating Circulating

 

NANDA, VIKAS

 

UNIV OF MED/DENT NJ-R W JOHNSON MED SCH

 

Computational Design of a Synthetic Extracellular Matrix

 

ORDWAY, DIANE JOYCE.

 

COLORADO STATE UNIVERSITY-FORT COLLINS

 

Immune Modulation by Highly Virulent Clinical Isolates of M.TuberculosisARRA Logo

 

OZCAN, AYDOGAN

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Towards Mega-Throughput, Label-Free Genomics and Proteomics: Revolutionizing Micr

 

PAYNE, CHRISTINE K

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Intracellular Delivery and Targeting of Nanoparticles

 

PENN, ANNA A

 

STANFORD UNIVERSITY

 

Fetal Brain Damage: A Placental Disorder

 

PURDON, PATRICK L

 

MASSACHUSETTS GENERAL HOSPITAL

 

A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia

 

QIAN, SHU-BING

 

CORNELL UNIVERSITY ITHACA

 

Engineering Ubiquitin Ligases to Investigate Protein Aggregation and Neurodegener

 

QIAN, WEI-JUN

 

BATTELLE PACIFIC NORTHWEST LABORATORIES

 

A Universal Multiplex Assay System for High-Throughput Clinical Applications

 

REIJMERS, LEON

 

TUFTS UNIVERSITY BOSTON

 

Molecular Analysis of Functional Neural Circuits

 

REINEKE, THERESA M

 

VIRGINIA POLYTECHNIC INST AND ST UNIV

 

Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery

 

RINN, JOHN LOUIS

 

BETH ISRAEL DEACONESS MEDICAL CENTER

 

RNA and Chromatin Formation: From Discovery to Mechanism

 

SABETI, PARDIS CHRISTINE

 

HARVARD UNIVERSITY

 

Host and Pathogen Evolution in Lassa Fever

 

SAINT-GENIEZ, MAGALI

 

SCHEPENS EYE RESEARCH INSTITUTE

 

Bioengineering of Bruch's Membrane for the Treatment of Age-Related Macular Degeneration

 

SHOU, WENYING

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

Cellular Cooperation and Cheating: An Experimental and Mathematical Analysis

 

SONNENBURG, JUSTIN

 

STANFORD UNIVERSITY

 

Discovery of Gut Microbiota-Targeted Small Molecules: New Tools and TherapeuticsARRA Logo

 

TAVAZOIE, SOHAIL F

 

ROCKEFELLER UNIVERSITY

 

The Discovery of microRNAs that Predict Chemotherapeutic Responsiveness of CancerARRA Logo

 

TIMLIN, JERILYN

 

SANDIA CORP-SANDIA NATIONAL LABORATORIES

 

Multiplexed Measurements of Protein Dynamics and Interactions at Extreme Resolution

 

TSO, CHO-LEA

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Cellular Quiescence and Brain Tumor Stem Cells

 

ULLIAN, ERIK M

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

The Role of Astrocytes in Plasticity and Disease

 

VEZYS, VAIVA D

 

UNIVERSITY OF MINNESOTA TWIN CITIES

 

Understanding the Persistence of Immune-Mediated Chronic Diseases

 

WEINBERGER, LEOR S

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Developing Transmissible Antivirals by Exploiting Gene-Expression CircuitryARRA Logo

 

ZHANG, CHUN-LI

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

Neurogenesis De Novo in the Adult Central Nervous System

 

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2008 NIH Director's New Innovator Award Program (DP2)
RFA-RM-08-014
PI Name Institution Name Title
BRYANT, ZEV

 

STANFORD UNIVERSITY

 

Engineering Molecular Motors

 

BUCKANOVICH, RONALD J

 

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

 

Using Embryonic Stem Cells to Re-Create a Human Tumor Microenvironment to Develop

 

CARDOZO, TIMOTHY J

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Chemical Biology Design for Malaria

 

CHRISTMAN, KAREN L

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Engineering a Dynamic Extracellular Matrix Microenvironment

 

COBB, BRIAN A

 

CASE WESTERN RESERVE UNIVERSITY

 

T cell Dependent Immune Responses to Carbohydrate Antigens

 

COHN, RONALD D

 

JOHNS HOPKINS UNIVERSITY

 

Maintenance of Skeletal Muscle Mass: Lessons Learned from Hibernation

 

DUAN, XIANGFENG

 

UNIVERSITY OF CALIFORNIA, LOS ANGELES

 

Integrated Free-Standing Nanoprobes for Neuroscience and Beyond

 

FIELD, SETH J

 

UNIVERSITY OF CALIFORNIA, SAN DIEGO

 

Phosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology

 

GITAI, ZEMER

 

PRINCETON UNIVERSITY

 

Discovering Antibiotic Drugs & Targets via High-Throughput Bacterial Cell Biology

 

GITLER, AARON D

 

UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE Using Yeast Cells to Define Mechanisms of Human Neurodegenerative Diseases

 

GRACIAS, DAVID H

 

JOHNS HOPKINS UNIVERSITY

 

Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine

 

HAYNES, CHRISTY L

 

UNIVERSITY OF MINNESOTA

 

Immune System-on-a-Chip for Quantitative Analysis of Cell Interactions During All

 

KESLER, SHELLI R

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE

 

Assessment and Treatment of Cognitive Deficits in Breast Cancer

 

KIRICHOK, YURIY

 

UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO

 

Molecular Biophysics of Mitochondrial Membranes: Defining Future Therapeutic Targets

 

KUMAR, SANJAY

 

UNIVERSITY OF CALIFORNIA, BERKELEY

 

Cellular Mechanobiology: Biophysics and Therapeutics

 

KUO, CHAY T

 

DUKE UNIVERSITY MEDICAL CENTER

 

Discovering Pathways Regulating Neurogenesis and Brain Remodeling after Injury

 

MAHAL, LARA K

 

UNIVERSITY OF TEXAS AT AUSTIN

 

An Integrated Systems Approach to Deconstructing Glycosylation

 

MURPHY, COLEEN TARA

 

PRINCETON UNIVERSITY LEWIS-SIGLER INSTITUTE

 

Slowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators

 

NOMA, KENICHI

 

WISTAR INSTITUTE

 

A New Methodology to Decipher Three-Dimensional Genome Structure

 

OHI, MELANIE DIANE

 

VANDERBILT UNIVERSITY MEDICAL CENTER

 

Multifaceted Approaches for Studying the Structure and Function of Spliceosomes

 

PFENNIG, KARIN S

 

UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL

 

The Origins and Maintenance of Context-Dependent Behavior

 

RAMALHO-SANTOS, MIGUEL

 

UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO

 

Role of Pluripotency in Development of the Germline

 

RECK-PETERSON, SAMARA L

 

HARVARD MEDICAL SCHOOL

 

Cellular Control of Microtubule-Based Transport: Unraveling Its Molecular Mechanism

 

SHAPIRO, ERIK

 

YALE UNIVERSITY SCHOOL OF MEDICINE

 

Single Cell MRI of Directed Cell Migration to Stroke

 

SHIH, WILLIAM M DANA-FARBER CANCER INSTITUTE

 

NMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes

 

WAGERS, AMY JO

 

JOSLIN DIABETES CENTER

 

Aging and Rejuvenation of the Hematopoietic Stem Cell Niche

 

WANG, JUE D

 

BAYLOR COLLEGE OF MEDICINE

 

The Molecular Interface of Replication Elongation and the Cellular Environment

 

WANG, LEI

 

SALK INSTITUTE OF BIOLOGICAL STUDIES

 

Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans

 

WU, JOSEPH C

 

STANFORD UNIVERSITY SCHOOL OF MEDICINE

 

09: Inducing Pluripotency with MiRNAs: New Paradigm Shif in Cell Reprogramming

 

WU, SEAN M

 

MASSACHUSETTS GENERAL HOSPITAL

 

Generation of Functional Organs via Developmental Chimerism

 

ZEITLINGER, JULIA

 

STOWERS INSTITUTE FOR MEDICAL RESEARCH

 

Investigating Developmental Potential Based on Genome-wide Chromatin Status

 

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2007 NIH Director's New Innovator Award Program
(DP2)RFA-RM-07-009
PI Name Institution Name Title
AAGAARD-TILLERY, KJERSTI

 

BAYLOR COLLEGE OF MEDICINE

 

Characterization of the Fetal Primate Epigenome and Metabolome Under In Utero

 

BAILEY, RYAN

 

UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN

 

Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays

 

BOYDEN, EDWARD

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Novel Tools and Principles for Precisely Controlling Brain Activity

 

CHAMPAGNE, FRANCES

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Epigenetic Mechanisms Mediating the Inheritance of Reproductive Behavior

 

DAVIES, SEAN

 

VANDERBILT UNIVERSITY

 

Transformed Probiotic Bacteria for Treatment of Chronic Diseases

 

FERNANDEZ-FUNEZ, PEDRO

 

UNIVERSITY OF TEXAS MEDICAL BR GALVESTON

 

Mechanisms of Prion Misfolding

 

FORTUNE, SARAH

 

HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)

 

Variation in M. tuberculosis in Response to Host Selection

 

GARRAWAY, LEVI

 

DANA-FARBER CANCER INSTITUTE

 

Defining Melanoma Therapeutic Avenues by Integrative Functional Genomics

 

GUMBO, TAWANDA

 

UNIVERSITY OF TEXAS SW MED CTR/DALLAS

 

Efflux Pump Inhibitors to Reduce Duration of Antituberculosis Therapy

 

HACOHEN, NIR

 

MASSACHUSETTS GENERAL HOSPITAL

 

Revealing Pathogen-Sensing Pathways Using RNAi Libraries

 

HELDWEIN, EKATERINA

 

TUFTS UNIVERSITY BOSTON

 

Structural and Mechanistic Studies of Herpesvirus Entry into Host Cells

 

HOCHEDLINGER, KONRAD

 

MASSACHUSETTS GENERAL HOSPITAL

 

Reprogramming of Somatic Cells by Defined Factors

 

JACOBSON, KRISTEN

 

UNIVERSITY OF CHICAGO

 

From Neighborhoods to Neurons and Beyond

 

JANKOWSKY, JOANNA

 

CALIFORNIA INSTITUTE OF TECHNOLOGY

 

Selective Neuronal Silencing to Study Cognitive Decline in Alzheimer's Disease

 

JASANOFF, ALAN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Genetically-Controlled MRI Contrast Agents for Functional Brain Imaging

 

JOHNSON, MARK

 

BRIGHAM AND WOMEN'S HOSPITAL

 

MicroRNA Biogenesis and the Cancer Proteome

 

LLINAS, MANUEL

 

PRINCETON UNIVERSITY

 

Novel Antimalarial Strategies Using Metabolomic Network Discovery

 

PAPA, FEROZ

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living

 

PE'ER, DANA

 

COLUMBIA UNIV NEW YORK MORNINGSIDE

 

Genetic Variation and Regulatory Networks: Mechanisms and Complexity

 

PLATH, KATHRIN

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Chromatin and Epigenetic Inheritance

 

RAPE, MICHAEL

 

UNIVERSITY OF CALIFORNIA BERKELEY

 

Ubiquitin-Dependent Mechanisms of Tissue-Specific Cell Cycle Control

 

ROSENBLATT, JODY

 

UNIVERSITY OF UTAH

 

Identification of Signals that Extrude an Apoptotic Cell from an Epithelium

 

SAGHATELIAN, ALAN

 

HARVARD UNIVERSITY

 

Discovery Metabolite Profiling of the Prolyl Peptidases

 

SHORTER, JAMES

 

UNIVERSITY OF PENNSYLVANIA

 

Amyloid Elimination by Hsp104 and Substrate-Optimized Variants

 

SIPKINS, DOROTHY

 

UNIVERSITY OF CHICAGO

 

Stem Cell, Tumor and Bone Marrow Microenvironment Cross-Talk In Vivo

 

SPIEGEL, DAVID

 

YALE UNIVERSITY

 

Small-Molecule Antibody Recruiting Therapeutics for Treating Human Disease

 

SZIGETHY, EVA

 

UNIVERSITY OF PITTSBURGH AT PITTSBURGH

 

Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Ill

 

TOOMRE, DEREK

 

YALE UNIVERSITY

 

Novel TIRF Microscopy for Analyzing Trafficking and Signaling at the Cell Co

 

YANG, JING

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Epithelial-Mesenchymal Transition in Tumor Metastasis

 

YANIK, MEHMET

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Development of On-Chip Ultra High-Throughput Whole-Animal Assay Technologies
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