NIH Director's New Innovator Award

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Funded Research

PI Name	Institution Name	Title
2013 NIH Director’s New Innovator Award Program (DP2) RFA-RM-12-016
ADESNIK, HILLEL	UNIVERSITY OF CALIFORNIA BERKELEY	New Optical Strategies to Unlock the Neural Basis of Perception
AHERN, JENNIFER	UNIVERSITY OF CALIFORNIA BERKELEY	A Rigorous System to Determine the Health Impacts of Policies and Programs
ALDRIDGE, BREE BEARDSLEY	TUFTS UNIVERSITY BOSTON	Quantitative Design of Multi-drug Regiments for Tuberculosis
ATON, SARA J	UNIVERSITY OF MICHIGAN	Linking network activity and intracellular plasticity mechanisms during sleep-dep
BLISH, CATHERINE A	STANFORD UNIVERSITY	Harnessing natural killer cell memory to fight viruses
CRAWFORD, JASON MICHAEL	YALE UNIVERSITY	Cryptic gut bacterial metabolites that regulate colorectal cancer formation
DAR, ARVIN	MOUNT SINAI SCHOOL OF MEDICINE	Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase
DEO, RAHUL CHANDRAKANT	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies
DIEHN, MAXIMILIAN	STANFORD UNIVERSITY	Developing a genomic approach for cancer screening
DVORIN, JEFFREY D	CHILDREN'S HOSPITAL CORPORATION	Essential gene discovery in the malaria parasite Plasmodium falciparum
ESSER-KAHN, AARON PALMER	UNIVERSITY OF CALIFORNIA IRVINE	Directing the Immune System via Polymeric Combinations of Molecular Signals
EVANS, SCOTT E	UT MD ANDERSON CANCER CTR	Inducible epithelial antiviral resistance to prevent asthma
FIEDLER, DOROTHEA	PRINCETON UNIVERSITY	Understanding phosphate metabolism in cancer and metastasis
FROST, ADAM	UNIVERSITY OF UTAH	Toward Atomic Resolution of Membranes and Membrane-Associated Machines
GANDHI, SUNIL	UNIVERSITY OF CALIFORNIA IRVINE	Rewiring cortex using inhibitory neuron transplantation
GARTNER, ZEV JORDAN	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	Total synthesis of the human mammary gland
GRADINARU, VIVIANA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Neuromodulation and Neurodegeneration: the Missing Link and Mechanisms of Action
GREGG, ROBERT D	UNIVERSITY OF TEXAS DALLAS	PHASE-BASED CONTROL OF LOCOMOTION FOR HIGH-PERFORMANCE PROSTHESES AND ORTHOSES
HANSEN, SCOTT B	SCRIPPS FLORIDA	Molecular Mechanism of Mechanosensation
LAMB, TRACEY JANE	EMORY UNIVERSITY	The development of probiotic yeast as an inexpensive vaccine delivery platform
LUCKS, JULIUS BEAU	CORNELL UNIVERSITY	A New High-Throughput Technology To Reveal The Dynamic Functional States of RNAs
MARR, LINSEY	VIRGINIA POLYTECHNIC INST AND ST UNIV	The Role of Pathogen-Environment Interactions in the Pandemic Potential of Influe
MERRIKH, HOURA	UNIVERSITY OF WASHINGTON	Targeted Gene Evolution via Replication-Transcription Conflicts
MORTAZAVI, SEYED ALI	UNIVERSITY OF CALIFORNIA IRVINE	Comparative analysis of the 4D encoding of regulatory networks in stem cells
O'CONNELL, RYAN	UNIVERSITY OF UTAH	Utilizing TALEN technology to regulate human microRNAs
ONNELA, JUKKA-PEKKA	HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)	Using mobile phones for social and behavioral sensing of mood disorder patients
PETERSEN, CHRISTIAN	NORTHWESTERN UNIVERSITY	Regulatory Circuits Controlling Regenerative Growth
PEYTON, SHELLY R	UNIVERSITY OF MASSACHUSETTS AMHERST	Tissue-specific stem cells and breast cancer tissue tropism
RUTA, VANESSA	ROCKEFELLER UNIVERSITY	Connecting Neural Plasticity to Learning and Memory
SAHIN, OZGUR	COLUMBIA UNIV NEW YORK MORNINGSIDE	Novel sub-cellular chemical and mechanical nanoimaging
SANJABI, SHOMYSEH	J. DAVID GLADSTONE INSTITUTES	Characterizing HIV latent reservoir in vivo
SATTELY, ELIZABETH SUSAN	STANFORD UNIVERSITY	Liberation of Plant Nutrients by the Gut Microbiota
SAVAGE, DAVID FRANK	UNIVERSITY OF CALIFORNIA BERKELEY	Fluorescent biosensors for metabolite imaging in live cells
SEANDEL, MARCO	WEILL MEDICAL COLL OF CORNELL UNIV	Clonal competition in stem cells as a driver of paternal age effect diseases
SIVARAMAKRISHNAN, SIVARAJ	UNIVERSITY OF MICHIGAN	The kinase toolbox: Mapping the spatial and temporal regulation of cell signaling
TAYLOR, DEREK JAMES	CASE WESTERN RESERVE UNIVERSITY	Induction of cancer cell death by selective DNA misincorporation
TISCHLER, ANNA DEGRAFF	UNIVERSITY OF MINNESOTA	High-Throughput Identification of Mycobacterium tuberculosis Persistence Mechanis
TYE, KAY MAXINE	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
WHITE, RICHARD MARK	SLOAN-KETTERING INST CAN RES	Evolutionary dynamics of melanoma metastasis
WONG, WILSON	BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)	Synthetically Reengineered T cells as the Next Generation of Smart Cancer Therapy
ZHENG, YING	UNIVERSITY OF WASHINGTON	A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis

PI Name	Institution Name	Title
2012 NIH Director’s New Innovator Award Program (DP2) RFA-RM-11-005
ALLEN, CHRISTOPHER DAVID	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Cellular interactions in asthma
AUGUSTE, DEBRA	HARVARD UNIVERSITY	Personalized therapeutics for inhibiting breast cancer metastasis
BALSKUS, EMILY PATRICIA	HARVARD UNIVERSITY	Biocompatible Chemistry for In Vivo Metabolite Modification
BIVONA, TREVER G	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Discovery of Rational Companion Therapeutic Targets to Optimize Cancer Treatment
BONKOWSKY, JOSH LEITCH	UNIVERSITY OF UTAH	Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon Reorganiz
BORENSTEIN, ELHANAN	UNIVERSITY OF WASHINGTON	A Computational Framework for Designing Microbiome Manipulation
BRANGWYNNE, CLIFFORD P	PRINCETON UNIVERSITY	Cell growth control by cell and organelle size-dependent ribosome biogenesis
CAMP, AMY HITCHCOCK	LEHIGH UNIVERSITY	A Feeding Tube Model for Bacterial Cell-Cell Communication
CARETTE, JAN EDUARD	STANFORD UNIVERSITY	Genetic approaches to discover host factors critical to dengue virus infection
CHEN, SHUIBING	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Studying the Progression and Regression of Beta Cell Dysfunction in Type 2 Diabet
CHI, PING	SLOAN-KETTERING INSTITUTE FOR CANCER RES	An integrative approach to target lineage-specific oncogenic transcription factor
CHURCHLAND, MARK	COLUMBIA UNIVERSITY HEALTH SCIENCES	A dynamical systems approach to fundamental questions in neuroscience
CUI, BIANXIAO	STANFORD UNIVERSITY	Engineering external forces for manipulating cargo transport in live neurons
DANTAS, GAUTAM	WASHINGTON UNIVERSITY	Metagenomic Engineering of Probiotic Bacteria to Improve Intestinal Colonization
DONG, P. DUC SI	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	Unlocking Regenerative Potential through in Vivo Genetic Reprogramming
FALK, EMILY	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Can neuroscience dramatically improve our ability to design health communications
FEINBERG, ADAM WALTER	CARNEGIE-MELLON UNIVERSITY	Human Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds
GILL, HARVINDER SINGH	TEXAS TECH UNIVERSITY	Pollen Grains as Trojan Horses for Oral Vaccination
GOODMAN, ANDREW L	YALE UNIVERSITY	Defining the contribution of interpersonal microbial variation to drug metabolism
GORE, JEFF	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Early warning indicators of tipping points in biological systems
HAN, XUE	BOSTON UNIVERSITY	Light-Actuatable NanoRobots for Molecular Uncaging
HELLER, DANIEL ALAN	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Transient Metabolite Detection for Single-Cell Metabolomics and Diagnostics
HIGGINS, JOHN MATTHEW	MASSACHUSETTS GENERAL HOSPITAL	Systems Biology of In Vivo Human Blood Cell Populations
JOHNSON, LAURA A	DUKE UNIVERSITY	Gene-engineered adoptive T cell immunotherapy of GBM
KOHLI, RAHUL MANU	UNIVERSITY OF PENNSYLVANIA	Combating Bacterial Drug Resistance by Targeting the Enzymes of Evolution
KRONAUER, DANIEL	ROCKEFELLER UNIVERSITY	Studying the molecular mechanisms of social life using a novel ant model system
LILLEMEIER, BJOERN F.	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Decipher membrane patterns in situ with super-resolution and dynamic microscopy
LIU, ALLEN PO-CHIH	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Building artificial platelets
LIU, WENDY	UNIVERSITY OF CALIFORNIA IRVINE	Engineering Biomaterials to Exert Molecular Control of Immune Cell Function
MAIMON, GABY	ROCKEFELLER UNIVERSITY	Linking genes to higher brain function by way of cellular electrophysiology
MARRAFFINI, LUCIANO A	ROCKEFELLER UNIVERSITY	Using CRISPR immunity to prevent the spread of virulence traits among pathogens
MIN, WEI	COLUMBIA UNIV NEW YORK MORNINGSIDE	Label-Free Chemical Imaging for Biological Applications
MYONG, SUA	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Quantitative stepwise analysis of RNA interference
NIELL, CRISTOPHER	UNIVERSITY OF OREGON	Connecting developmental mechanisms to visual function and perception
NIMMERJAHN, AXEL	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Novel approaches to study microglia physiology and pathology in the intact brain
PERMAR, SALLIE R.	DUKE UNIVERSITY	Maternal immune protection against congenital CMV infection
PERTSINIDIS, ALEXANDROS	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Understanding Gene Transcription from First-Principles: A single-molecule study
PRLIC, MARTIN	FRED HUTCHINSON CANCER RESEARCH CENTER	Paving the Way for a Novel Therapeutic Approach to Combat HIV
RODAL, AVITAL ADAH	BRANDEIS UNIVERSITY	Activity-dependent regulation of membrane traffic and growth signaling in neurons
ROHATGI, RAJAT	STANFORD UNIVERSITY	Reconstructing Primary Cilia
SCHAEFER, ANNE	MOUNT SINAI SCHOOL OF MEDICINE	Cognate microglia-neuron interaction and its role in inflammation
SHU, XIAOKUN	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	New principle-based technologies for identifying transient protein interactions
SOHAL, VIKAAS SINGH	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Reverse engineering the prefrontal microcircuit
STOLTZ, DAVID A	UNIVERSITY OF IOWA	Airway Goblet Cells: Friend or Foe?
SU, MING	UNIVERSITY OF CENTRAL FLORIDA	Enhanced radiation therapy with nanoscale frequency modulators
URBAN, ALEXANDER ECKEHART	STANFORD UNIVERSITY	Genomic and epigenomic effects of large CNV in neurons from iPSC
WITTEN, ILANA	PRINCETON UNIVERSITY	Therapeutic plasticity: a novel paradigm for treating addiction
WOODROW, KIM A.	UNIVERSITY OF WASHINGTON	Nanomaterials for engineering protection in the genital mucosa
YOO, ANDREW	WASHINGTON UNIVERSITY	Microrna and Neural Factor-Mediated Direct Reprogramming of Cell Fates
ZHENG, SIYANG	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	Integration of Flexible Micro Spring Array and High Throughput Microfluidics for Obtaining Clinical Relevant Information from Circulating Tumor Cells
ZOVEIN, ANN CAPELA	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Engineering human endothelium for hematopoietic stem cell production

PI Name	Institution Name	Title
2011 NIH Director’s New Innovator Award Program (DP2) RFA-RM-10-009
ALLER, STEPHEN G	UNIVERSITY OF ALABAMA AT BIRMINGHAM	Streamlined Structures of Human Integral Membrane Proteins at Atomic Resolution
BAKER, AARON BLAIR	UNIVERSITY OF TEXAS AUSTIN	Engineering Effective Revascularization Strategies for Ischemia in Disease States
BARNA, MARIA	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Specialized ribosomes in control of gene expression and embryonic development
BASU, UTTIYA	COLUMBIA UNIVERSITY HEALTH SCIENCES	Non-coding RNA engineers antibody diversity
BUCHLER, NICOLAS EMILE	DUKE UNIVERSITY	Rewiring the yeast brain: Redundancy and interference in genetic networks
CAI, LONG	CALIFORNIA INSTITUTE OF TECHNOLOGY	Systems Biology in Single Cells by Super-resolution Barcoding
CANMAN, JULIE C	COLUMBIA UNIVERSITY HEALTH SCIENCES	IR-LAMP: Optigenetic technology to spatially manipulate protein function in vivo
CARLSON, ERIN ELIZABETH	INDIANA UNIVERSITY BLOOMINGTON	Targeted natural product diversification to identify novel antibacterial agents
CHANG, EDWARD	UNIVERSITY OF CALIFORNIA SAN DIEGO	Functional Architecture of Human Speech Motor Cortex
CHANG, JOHN T	UNIVERSITY OF CALIFORNIA SAN DIEGO	Understanding the Basis for Cellular Diversity During Adaptive Immunity
CHANG, MICHELLE C	UNIVERSITY OF CALIFORNIA BERKELEY	Discovery and mechanistic study of fluorine biochemistry
CHENG, WEI	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Single Cell with One Particle Entry (SCOPE) for Study of HIV Infection
CHRISTOFK, HEATHER RENEE	UNIVERSITY OF CALIFORNIA LOS ANGELES	Regulation of the Warburg Effect in Cancer
FRASER, HUNTER B	STANFORD UNIVERSITY	Systematic functional annotation of human cis-regulatory genetic variation
GERSBACH, CHARLES A	DUKE UNIVERSITY	Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming
GEURTS, ARON M	MEDICAL COLLEGE OF WISCONSIN	Advanced genetic engineering technology development
GIANNESCHI, NATHAN CLAUDE	UNIVERSITY OF CALIFORNIA SAN DIEGO	Programming Pharmacokinetics in Vivo via In Situ Switching of Nanoscale Particle
GOENTORO, LEA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Relative perception in Wnt signaling
HAMMOND, MING CHEN	UNIVERSITY OF CALIFORNIA BERKELEY	A Chemical Biology Approach to Tagging RNAs in Live Cells
HAN, SONGI	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Probing early protein aggregation mechanisms and their relationship to disease ef
HUANG, BO	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Solving macromolecular complex architecture in situ by super-resolution microscop
HUG, CHRISTOPHER	CHILDREN'S HOSPITAL BOSTON	Macrophage Integrated and Targeted Yeast Therapeutics
JIANG, HONGRUI	UNIVERSITY OF WISCONSIN MADISON	ACCOMMODATIVE CONTACT LENs FOR PRESBYOPIC CORRECTION
KALANTRY, SUNDEEP	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Initiation of Epigenetic Transcriptional Regulation
KASKO, ANDREA MARIE	UNIVERSITY OF CALIFORNIA LOS ANGELES	PHOTOTUNABLE BIOMATERIALS TO ENGINEER COMPLEX 3D CELL MICROENVIRONMENTS
KING, MEGAN C	YALE UNIVERSITY	The role of nuclear architecture in adaptation
KOSAK, STEVEN TODD	NORTHWESTERN UNIVERSITY	Self-Organization of the Human Genome
LAMICHHANE, GYANU	JOHNS HOPKINS UNIVERSITY	New Drug for Treatment of Chronic Bacterial Infection
LEE, SEOK-YONG	DUKE UNIVERSITY	Pharmacology and biophysics of the voltage-gated sodium channel Nav1.7
LEE, SHAUN W	UNIVERSITY OF NOTRE DAME	Design and Use of Novel Bacteriocins
LIEBERMAN AIDEN, EREZ	BROAD INSTITUTE, INC.	Exploring how the genome folds through proximity ligation and sequencing
LU, TIMOTHY	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-Throughput Nanoscale Approaches to Studying and Inhibiting Amyloid Toxicity
MAVERAKIS, EMANUAL M	UNIVERSITY OF CALIFORNIA DAVIS	Investigation and Development of New Therapeutic Avenues for Scleroderma
MITCHELL, DOUGLAS ALAN	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	A common denominator of pathogenesis; a rare opportunity for novel therapeutic de
OTT, HARALD C	MASSACHUSETTS GENERAL HOSPITAL	Organ engineering based on perfusion decellularized matrix
PADERA, TIMOTHY P.	MASSACHUSETTS GENERAL HOSPITAL	Characterizing lymphatic micrometastases: prognostic and therapeutic implications
PAEGEL, BRIAN M	SCRIPPS FLORIDA	Evolving and Engineering New Protease Tools for Mass Spectrometry Proteomics
PETRASCHECK, MICHAEL	SCRIPPS RESEARCH INSTITUTE	Modulation of Sensory Perception to Treat Age Related Disease
QUEITSCH, CHRISTINE	UNIVERSITY OF WASHINGTON	Does organismal robustness explain the missing heritability in complex diseases?
RAJ, ARJUN	UNIVERSITY OF PENNSYLVANIA	Comprehensive Spatial Picture of Transcription in the Nucleus
SCHLIEKER, CHRISTIAN DIRK	YALE UNIVERSITY	Deciphering novel protein quality control pathways in the nuclear periphery
TOBIN, DAVID M	DUKE UNIVERSITY	Modulating Eicosanoids to Treat Tuberculosis: Personalized, Host-directed Therapy
WANG, CHIHHUNG JASON	BOSTON MEDICAL CENTER	Healthy Ideas Exchange
WEIBEL, DOUGLAS BENJAMIN	UNIVERSITY OF WISCONSIN MADISON	Revisiting the bacterial cell wall as a target for new antibiotics
WINGERT, REBECCA ANN	UNIVERSITY OF NOTRE DAME	Identification of Kidney Regeneration Mechanisms Using the Zebrafish
WU, JOY Y	MASSACHUSETTS GENERAL HOSPITAL	"In vivo reconstitution of the hematopoietic niche"
XAVIER, JOAO	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Engineering microbial social interactions: Towards new anti-biofilm therapies
ZHANG, QI	VANDERBILT UNIVERSITY	Explore fundamental aspects of neurotransmission with multifunctional nanosensor
ZHONG, HAINING	OREGON HEALTH AND SCIENCE UNIVERSITY	Examining the architecture of synapses in brain tissue at nanometer resolution

PI Name	Institution Name	Title
2010 NIH Director's New Innovator Award Program (DP2) RFA-RM-09-011
AGAR, NATHALIE YR	BRIGHAM & WOMEN'S HOSPITAL	Real-Time Stereotactic Mass Spectrometry Tissue Analysis for Intraoperative Neuro
AGARWAL, RITESH	UNIVERSITY OF PENNSYLVANIA	Optoelectronic Nanowire Probes for Investigation of Intra-Cellular Processes
AMARO, ROMMIE E	UNIVERSITY OF CALIFORNIA IRVINE	A Structural Systems Biology Approach to Drug Discovery
ARAVIN, ALEXEI A	CALIFORNIA INSTITUTE OF TECHNOLOGY	Taming of Small RNA-based Epigenetic Mechanisms
ARMANI, ANDREA MARTIN	UNIVERSITY OF SOUTHERN CALIFORNIA	Ultrasensitive Nanolasers For Epigenetics Investigations
BAUTISTA, DIANA MICHELE	UNIVERSITY OF CALIFORNIA BERKELEY	New approaches to identify molecular mechanisms of touch and pain in mammals
CEGELSKI, LYNETTE S	STANFORD UNIVERSITY	Structure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm For
CHENG, JIANJUN	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates
CHANG, EDWARD	UNIVERSITY OF CALIFORNIA SAN DIEGO	Functional Architecture of Human Speech Motor Cortex
CHI, NEIL C	UNIVERSITY OF CALIFORNIA SAN DIEGO	Directed Cardiac Cellular Programming: A New Paradigm for Cardiac Regeneration
COHEN, ADAM EZRA	HARVARD UNIVERSITY	Optical Sensing of Voltage, pH, and Small Molecules Using Microbial Rhodopsins
DAI, CHENGKAI	JACKSON LABORATORY	Role of a Novel Stress Response Mechanism-Genetic Buffering-in Tumor Evolution
DATTA, SANDEEP R	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Revealing Fear: New Methods To Study Neural Circuits, Behavior And Disease
DI CARLO, DINO	UNIVERSITY OF CALIFORNIA LOS ANGELES	Engineering The Intracellular Micro- And Nanoenvironment
DUNN, ALEXANDER R	STANFORD UNIVERSITY	Uncovering New Roles For Mechanical Force in Tissue Development and Remodeling
EVANS, CONOR LEE	MASSACHUSETTS GENERAL HOSPITAL	Imaging And Overcoming Hypoxia-Induced Resistance In Metastatic Ovarian Cancer
FELDMAN, BRIAN J	STANFORD UNIVERSITY	Using Components Of The Circadian Clock To Regulate Stem Cell Fate Decisions
FISCHBACH, MICHAEL ANDREW	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Identifying And Characterizing Small Molecules From The Human Microbiome
FLAMINIO, MARIA JULIA B. F.	CORNELL UNIVERSITY ITHACA	Epigenetics: A Novel Approach in Primary Immunodeficiencies
GARCIA, BENJAMIN A	PRINCETON UNIVERSITY	Novel Methodology For Quantitative High-Throughput Cancer Epigenetics
GUZMAN, MONICA L	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Selection Of Novel Therapies To Ablate Chemoresistant Myeloid Leukemia Stem Cell
HERR, AMY ELIZABETH	UNIVERSITY OF CALIFORNIA BERKELEY	Towards High Throughput Proteomics: A Micro/Nanofluidic Framework for Blotless W
HOTOPP, JULIE	UNIVERSITY OF MARYLAND BALTIMORE	Impact of Bacterial-Animal Lateral Gene Transfer on Human Health
HUANG, TONY JUN	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	On-Chip Optofluidic Laser Scanning Confocal Microscope for Early Cancer Detection
HUANG, YU	UNIVERSITY OF CALIFORNIA LOS ANGELES	Graphene Nanostructures As A New Platform For Ultrasensitive Multiplexed Biologic
KHINE, MICHELLE	UNIVERSITY OF CALIFORNIA IRVINE	Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
KLEIN, OPHIR D	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	An Evolutionary-Developmental Approach to Stem Cells Using Teeth as a Mode
KRITZER, JOSHUA A	TUFTS UNIVERSITY MEDFORD	Drugging The Undruggable: Targeting Transcription Factors With Small Cyclic Pept
LAIRD, DIANA J	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Cell Competition in the Developing Mouse Germline
LAVIK, ERIN	CASE WESTERN RESERVE UNIVERSITY	Clinically Translatable Nanotechnology: Hemostasis And Neuroprotection
LEE, JIN HYUNG	UNIVERSITY OF CALIFORNIA LOS ANGELES	In Vivo Control and Functional Visualization of Stem Cell-Driven Cns Regeneration
LEVY, HARA	MEDICAL COLLEGE OF WISCONSIN, INC.	Integration of Genomics with Genetics - Molecular Phenotypes for CF Lung Disease
LEY, RUTH EMILY	CORNELL UNIVERSITY ITHACA	Development Of Immunization Strategies To Reshape Pathogenic Microbiomes
LUO, MINKUI	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Enzyme-Engineering Approaches to Dissect Protein Methylation Profiles
MAJOR, MICHAEL BENJAMIN	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Exploitation of Near-Haploid Human Cells for Functional Gene Discovery
MARCH, JOHN C	CORNELL UNIVERSITY ITHACA	Engineering Commensal Bacteria as Therapeutic Signal Mediators
NELSON, TIMOTHY J	MAYO CLINIC COLL OF MEDICINE, ROCHESTER	Dysfunctional Regeneration in Cardiomyopathy: Ips-Based Diagnosis and Therapy
NILES, JACQUIN C	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Engineered Regulated Rna Localization and Transport In Biological Systems
NOLAN, ELIZABETH M	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Antibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology
PLATT, MANU O	GEORGIA INSTITUTE OF TECHNOLOGY	Multiscale, Mechanistic, and Predictive Models of Stroke in Sickle Cell Disease
SEALE, PATRICK	UNIVERSITY OF PENNSYLVANIA	Molecular Regulation of Brown Adipose Cell Fate in Somitic Stem Cells
SITHARAMAN, BALAJI	STATE UNIVERSITY NEW YORK STONY BROOK	Nanotechnology-Based Theranostic Technology for Bone Tissue Engineering
THEOGARAJAN, LUKE SATISH KUMAR	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Bio-Ionic Neural Interfaces
TUCKER, BUDD ALBERT	SCHEPENS EYE RESEARCH INSTITUTE	Development of a Cell Replacement Therapy to Treat Retinal Degenerative Blindness
WADE, JOSEPH THOMAS	WADSWORTH CENTER	Pervasive Transcription in Bacterial Genomes
WEISS, LAUREN ANNE	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Dissecting Epistasis and Pleiotropy in Autism Towards Personalized Medicine
WONG, PAK KIN	UNIVERSITY OF ARIZONA	Mechanoregulation of Tissue Morphogenesis
YANG, CHANGHUEI	CALIFORNIA INSTITUTE OF TECHNOLOGY	Applications of Time-Reverse Tissue Turbidity Suppression to Improve Biophotonics
YIN, PENG	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Engineering Bioimaging Probes Based on Triggered Molecular Geometry
ZHAO, XILIN	UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL	Anaerobic Shock as a Novel Treatment for Tuberculosis
ZHONG, SHENG	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Evolutionary Models for Gene Regulatory Networks

PI Name	Institution Name	Title
2009 NIH Director's New Innovator Award Program (DP2) RFA-RM 09-003
ALBERS, MARK W	MASSACHUSETTS GENERAL HOSPITAL	The Olfactory Neural Circuit as a systems Level Model of Neurodegenerative Disease
ALMUTAIRI, ADAH	UNIVERSITY OF CALIFORNIA SAN DIEGO	Chemically Amplified Response Strategies For Medical Sciences; Concepts Borrowed
ASHLEY, EUAN A	STANFORD UNIVERSITY	Nanoscale Approaches To Allelic Silencing In Myocardial Disease States
BAGNAT, MICHEL	DUKE UNIVERSITY	Discovering New Regulators Of Cftr And Fluid Secretion In Zebrafish
BALAZSI, GABOR	UNIVERSITY OF TEXAS MD ANDERSON CAN CTR	Connecting The Selection Of Noisy Gene Expression Deviants To Genetic Evolution
BANERJEE, IPSITA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Defining Mechanisms Controlling Stem Cell Fate During Differentiation
BROWN, EDWARD BERNARD	UNIVERSITY OF ROCHESTER	Exploiting Collagen Organization To Predict And Prevent Tumor Metastasis
CAMARGO, FERNANDO	CHILDREN'S HOSPITAL BOSTON	Analysis Of Stem Cell Dynamics And Differentiation By Cellular Barcoding
CHRONIS, NIKOLAOS	UNIVERSITY OF MICHIGAN AT ANN ARBOR	A Biochip For Point-Of-Care Hiv/Aids Diagnosis In The Developing World
COHEN THEODORE H	BRIGHAM AND WOMEN'S HOSPITAL	Prevalence, Risk Factors And Consequences Of Complex M. Tuberculosis Infections
DERIEMER, KATHRYN	UNIVERSITY OF CALIFORNIA DAVIS	Transmission And Virulence Of Mycobacterium Tuberculosis
DIAZ, ELVA D	UNIVERSITY OF CALIFORNIA DAVIS	Generation Of Tumor Stem Cell Lines For Directed Therapeutics Of Brain Cancer
ENGLER, ADAM JEFFREY	UNIVERSITY OF CALIFORNIA SAN DIEGO	Smart' Materials To Engineer A More Complete Stem Cell Niche
GRISHOK, ALLA	COLUMBIA UNIVERSITY HEALTH SCIENCES	Investigating The Potential Of Endogenous Rnai In Mediating Adaptation To Environ
HALL, IRA M	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Extent, Origin, and Control of Structural Variation in Mammalian Genomes
HEILSHORN, SARAH C	STANFORD UNIVERSITY	Engineering 3D In Vitro Niches To Reveal Fundamentals Of Cellular Biomechanics
HUANG KERWYN CASEY	STANFORD UNIVERSITY	Engineering Of Cell Shape And Intracellular Organization
JAIN, SANJAY	JOHNS HOPKINS UNIVERSITY	Novel Imaging Biomarkers To Address Fundamental Controversies In Tb Pathogenesis
JANES, KEVIN A.	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein
KEMP, MELISSA LAMBETH	GEORGIA INSTITUTE OF TECHNOLOGY	Redox Regulation Of Cellular Information Processing
KREIMAN, GABRIEL	CHILDREN'S HOSPITAL BOSTON	Towards The Neuronal Correlates Of Visual Awareness
KRISTICH, CHRISTOPHER J	MEDICAL COLLEGE OF WISCONSIN	Genetic Approaches To Protein-Protein Interactions Mediating Antibiotic Resistanc
KURDISTANI, SIAVASH	UNIVERSITY OF CALIFORNIA LOS ANGELES	A Blueprint For Oncogenic Epigenetic Reprogramming
KWATE, NAA OYO A	COLUMBIA UNIVERSITY HEALTH SCIENCES	Immunologic Effects and a Structural "Countermarketing" Intervention: Racism, the
LEE, KIBUM	RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK	Combinatorial Approaches For Studying Multiple Cues Regulating Human Pluripotent
LIM, DANIEL A	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Chromatin-Based Cellular Memory In Neural Stem Cells
LOMVARDAS, STAVROS	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Characterization Of The Role Of Cpa Methylation In Neuronal Plasticity
MACHADO, ANDRE GUELMAN	CLEVELAND CLINIC LERNER COL/MED-CWRU	Deep Brain Stimulation Of The Ventral Anterior Limb Of The Internal Capsule For M
MASOPUST, DAVID	UNIVERSITY OF MINNESOTA TWIN CITIES	Maximizing Cd8 T Cells For Protection
MORA, JORGE RODRIGO	MASSACHUSETTS GENERAL HOSPITAL	Reassessing The Physiological Role Of Gut-Specific Lymphocyte Homing: Implication
MUOTRI, ALYSSON R	UNIVERSITY OF CALIFORNIA SAN DIEGO	Modeling Autism With Human Pluripotent Cells
NAGRATH, SUNITHA	MASSACHUSETTS GENERAL HOSPITAL	Engineering Sensitive Microfluidic Multiplex Technology For Isolating Circulating
NANDA, VIKAS	UNIV OF MED/DENT NJ-R W JOHNSON MED SCH	Computational Design Of A Synthetic Extracellular Matrix
ORDWAY, DIANE JOYCE.	COLORADO STATE UNIVERSITY-FORT COLLINS	Immune Modulation By Highly Virulent Clinical Isolates Of M.Tuberculosis
OZCAN, AYDOGAN	UNIVERSITY OF CALIFORNIA LOS ANGELES	Towards Mega-Throughput, Label-Free Genomics And Proteomics: Revolutionizing Micr
PAYNE, CHRISTINE K	GEORGIA INSTITUTE OF TECHNOLOGY	Intracellular Delivery And Targeting Of Nanoparticles
PENN, ANNA A	STANFORD UNIVERSITY	Fetal Brain Damage: A Placental Disorder
PURDON, PATRICK L	MASSACHUSETTS GENERAL HOSPITAL	A Neural Systems Approach To Monitoring And Drug-Delivery For General Anesthesia
QIAN, SHU-BING	CORNELL UNIVERSITY ITHACA	Engineering Ubiquitin Ligases To Investigate Protein Aggregation And Neurodegener
QIAN, WEI-JUN	BATTELLE PACIFIC NORTHWEST LABORATORIES	A Universal Multiplex Assay System for High-Throughput Clinical Applications
REIJMERS, LEON	TUFTS UNIVERSITY BOSTON	Molecular Analysis of Functional Neural Circuits
REINEKE, THERESA M	VIRGINIA POLYTECHNIC INST AND ST UNIV	Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery
RINN, JOHN LOUIS	BETH ISRAEL DEACONESS MEDICAL CENTER	RNA and Chromatin Formation: From Discovery to Mechanism
SABETI, PARDIS CHRISTINE	HARVARD UNIVERSITY	Host and Pathogen Evolution in Lassa Fever
SAINT-GENIEZ, MAGALI	SCHEPENS EYE RESEARCH INSTITUTE	Bioengineering of Bruch's Membrane for the treatment of Age-related Macular Degen
SHOU, WENYING	FRED HUTCHINSON CANCER RESEARCH CENTER	Cellular Cooperation and Cheating: an Experimental and Mathematical Analysis
SONNENBURG, JUSTIN	STANFORD UNIVERSITY	Discovery of gut microbiota-targeted small molecules: new tools and therapeutics
TAVAZOIE, SOHAIL F	ROCKEFELLER UNIVERSITY	The discovery of microRNAs that predict chemotherapeutic responsiveness of cancer
TIMLIN, JERILYN	SANDIA CORP-SANDIA NATIONAL LABORATORIES	Multiplexed Measurements of Protein Dynamics and Interactions at Extreme Resoluti
TSO, CHO-LEA	UNIVERSITY OF CALIFORNIA LOS ANGELES	Cellular Quiescence and Brain Tumor Stem Cells
ULLIAN, ERIK M	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	The Role Of Astrocytes In Plasticity And Disease
VEZYS, VAIVA D	UNIVERSITY OF MINNESOTA TWIN CITIES	The Role Of Astrocytes In Plasticity And Disease
WEINBERGER, LEOR S	UNIVERSITY OF CALIFORNIA SAN DIEGO	Developing Transmissible Antivirals by Exploiting Gene-Expression Circuitry
ZHANG, CHUN-LI	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Neurogenesis de novo in the adult central nervous system

PI Name	Institution Name	Title
2008 NIH Director's New Innovator Award Program (DP2) RFA-RM-08-014
BRYANT, ZEV	STANFORD UNIVERSITY	Engineering Molecular Motors
BUCKANOVICH, RONALD J	THE REGENTS OF THE UNIVERSITY OF MICHIGAN	Using embryonic stem cells to re-create a human tumor microenvironment to develop
CARDOZO, TIMOTHY J	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Chemical Biology Design For Malaria
CHRISTMAN, KAREN L	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Engineering a Dynamic Extracellular Matrix Microenvironment
COBB, BRIAN A	CASE WESTERN RESERVE UNIVERSITY	T cell Dependent Immune Responses to Carbohydrate Antigens
COHN, RONALD D	JOHNS HOPKINS UNIVERSITY	Maintenance of Skeletal Muscle Mass: Lessons Learned from Hibernation
DUAN, XIANGFENG	UNIVERSITY OF CALIFORNIA, LOS ANGELES	Integrated Free-standing Nanoprobes for Neuroscience and Beyond
FIELD, SETH J	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Phosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology
GITAI, ZEMER	PRINCETON UNIVERSITY	Discovering Antibiotic Drugs & Targets via High-Throughput Bacterial Cell Biology
GITLER, AARON D	UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE	Using yeast cells to define mechanisms of human neurodegenerative diseases
GRACIAS, DAVID H	JOHNS HOPKINS UNIVERSITY	Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine
HAYNES, CHRISTY L	UNIVERSITY OF MINNESOTA	Immune System-On-A-Chip For Quantitative Analysis Of Cell Interactions During All
KESLER, SHELLI R	STANFORD UNIVERSITY SCHOOL OF MEDICINE	Assessment and Treatment of Cognitive Deficits in Breast Cancer
KIRICHOK, YURIY	UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO	Molecular Biophysics of Mitochondrial Membranes: Defining Future Therapeutic Targ
KUMAR, SANJAY	UNIVERSITY OF CALIFORNIA, BERKELEY	Cellular mechanobiology: Biophysics and therapeutics
KUO, CHAY T	DUKE UNIVERSITY MEDICAL CENTER	Discovering pathways regulating neurogenesis and brain remodeling after injury
MAHAL, LARA K	UNIVERSITY OF TEXAS AT AUSTIN	An integrated systems approach to deconstructing glycosylation
MURPHY, COLEEN TARA	PRINCETON UNIVERSITY LEWIS-SIGLER INSTITUTE	Slowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators
NOMA, KENICHI	WISTAR INSTITUTE	A New Methodology to Decipher Three-Dimensional Genome Structure
OHI, MELANIE DIANE	VANDERBILT UNIVERSITY MEDICAL CENTER	Multifaceted Approaches for Studying the Structure and Function of Spliceosomes
PFENNIG, KARIN S	UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL	The origins and maintenance of context-dependent behavior
RAMALHO-SANTOS, MIGUEL	UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO	Role of pluripotency in development of the germline
RECK-PETERSON, SAMARA L	HARVARD MEDICAL SCHOOL	Cellular Control of Microtubule-Based Transport: Unraveling its Molecular Mechan
SHAPIRO, ERIK	YALE UNIVERSITY SCHOOL OF MEDICINE	Single cell MRI of directed cell migration to stroke
SHIH, WILLIAM M	DANA-FARBER CANCER INSTITUTE	NMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes
WAGERS, AMY JO	JOSLIN DIABETES CENTER	Aging and Rejuvenation of the hematopoietic stem cell niche
WANG, JUE D	BAYLOR COLLEGE OF MEDICINE	The Molecular Interface of Replication Elongation and the Cellular Environment
WANG, LEI	SALK INSTITUTE OF BIOLOGICAL STUDIES	Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans
WU, JOSEPH C	STANFORD UNIVERSITY SCHOOL OF MEDICINE	09: Inducing Pluripotency with MiRNAs: New Paradigm Shif in Cell Reprogramming
WU, SEAN M	MASSACHUSETTS GENERAL HOSPITAL	Generation of functional organs via developmental chimerism
ZEITLINGER, JULIA	STOWERS INSTITUTE FOR MEDICAL RESEARCH	Investigating Developmental Potential Based on Genome-wide Chromatin Status

PI Name	Institution Name	Title
2007 NIH Director's New Innovator Award Program (DP2)RFA-RM-07-009
AAGAARD-TILLERY, KJERSTI	BAYLOR COLLEGE OF MEDICINE	Characterization of the Fetal Primate Epigenome and Metabolome Under In Utero
BAILEY, RYAN	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
BOYDEN, EDWARD	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Novel Tools and Principles for Precisely Controlling Brain Activity
CHAMPAGNE, FRANCES	COLUMBIA UNIV NEW YORK MORNINGSIDE	Epigenetic Mechanisms Mediating the Inheritance of Reproductive Behavior
DAVIES, SEAN	VANDERBILT UNIVERSITY	Transformed Probiotic Bacteria for Treatment of Chronic Diseases
FERNANDEZ-FUNEZ, PEDRO	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	Mechanisms of Prion Misfolding
FORTUNE, SARAH	HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)	Variation in M. tuberculosis in response to host selection
GARRAWAY, LEVI	DANA-FARBER CANCER INSTITUTE	Defining Melanoma Therapeutic Avenues by Integrative Functional Genomics
GUMBO, TAWANDA	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Efflux pump inhibitors to reduce duration of antituberculosis therapy
HACOHEN, NIR	MASSACHUSETTS GENERAL HOSPITAL	Revealing pathogen-sensing pathways using RNAi libraries
HELDWEIN, EKATERINA	TUFTS UNIVERSITY BOSTON	Structural and mechanistic studies of herpesvirus entry into host cells
HOCHEDLINGER, KONRAD	MASSACHUSETTS GENERAL HOSPITAL	Reprogramming of somatic cells by defined factors
JACOBSON, KRISTEN	UNIVERSITY OF CHICAGO	From Neighborhoods to Neurons and Beyond
JANKOWSKY, JOANNA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Selective neuronal silencing to study cognitive decline in Alzheimer's disease
JASANOFF, ALAN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Genetically-controlled MRI contrast agents for functional brain imaging
JOHNSON, MARK	BRIGHAM AND WOMEN'S HOSPITAL	MicroRNA Biogenesis and the Cancer Proteome
LLINAS, MANUEL	PRINCETON UNIVERSITY	Novel antimalarial strategies using metabolomic network discovery
PAPA, FEROZ	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living
PE'ER, DANA	COLUMBIA UNIV NEW YORK MORNINGSIDE	Genetic variation and regulatory networks: Mechanisms and complexity
PLATH, KATHRIN	UNIVERSITY OF CALIFORNIA LOS ANGELES	CHROMATIN AND EPIGENETIC INHERITANCE
RAPE, MICHAEL	UNIVERSITY OF CALIFORNIA BERKELEY	Ubiquitin-dependent mechanisms of tissue-specific cell cycle control
ROSENBLATT, JODY	UNIVERSITY OF UTAH	Identification of signals that extrude an apoptotic cell from an epithelium
SAGHATELIAN, ALAN	HARVARD UNIVERSITY	Discovery metabolite profiling of the prolyl peptidases
SHORTER, JAMES	UNIVERSITY OF PENNSYLVANIA	Amyloid elimination by Hsp104 and substrate-optimized variants
SIPKINS, DOROTHY	UNIVERSITY OF CHICAGO	Stem cell, tumor and bone marrow microenvironment cross-talk in vivo
SPIEGEL, DAVID	YALE UNIVERSITY	Small-Molecule Antibody Recruiting Therapeutics for Treating Human Disease
SZIGETHY, EVA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Ill
TOOMRE, DEREK	YALE UNIVERSITY	Novel TIRF microscopy for analyzing trafficking and signaling at the cell co
YANG, JING	UNIVERSITY OF CALIFORNIA SAN DIEGO	Epithelial-Mesenchymal Transition in Tumor Metastasis
YANIK, MEHMET	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Development of on-chip ultra high-throughput whole-animal assay technologies

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