NIH Director's New Innovator Award

2023 NIH Director's New Innovator Award (DP2)

RFA-RM-22-019

PI Name	Institution Name	Title
AGUADO, BRIAN ALBERTO	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Probing sex differences in myocardial fibrosis at multiple length scales using biomaterials
ARIGO, DANIELLE	ROWAN UNIVERSITY	A Paradigm Shift in Health Behavior Change: Understanding When and How Social Comparison Supports Healthy Behavior
AYDOGAN, MUSTAFA GONENC	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Decoding the fundamental principles of autonomous clocks: mechanism, design and function
BALDWIN, KATHERINE THERESE	UNIV OF NORTH CAROLINA CHAPEL HILL	The facts of the matter: decoding the molecular properties of brain white matter using cell-type-specific quantitative proteomics
BANIK, STEVEN	STANFORD UNIVERSITY	Mapping and Therapeutic Hijacking of Lysosomal Transport
BARTELLE, BENJAMIN B	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Bioengineering Tools to Resolve and Manipulate Neuroimmune Signaling
BOSE, ROHIT	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Simulating Ancestrally Unbiased Tumor Evolution To Interrogate Drug Resistance
BURTON, NICHOLAS O	VAN ANDEL RESEARCH INSTITUTE	IDENTIFYING MICROBIAL MECHANISMS THAT REGULATE ANIMAL INSULIN SIGNALING
CARTER, CALVIN	UNIVERSITY OF IOWA	Targeting evolutionarily encoded molecular antennae to wirelessly reprogram systemic metabolism
COYLE, SCOTT M	UNIVERSITY OF WISCONSIN-MADISON	Cellular FM-radios: seeing, probing, and perturbing single-cell protein activity dynamics in biological systems with frequency-barcoded spatiotemporal signaling circuits
CROOK, NATHAN C	NORTH CAROLINA STATE UNIVERSITY RALEIGH	Brewing anti-toxin drugs using probiotic yeast
CROUCH, ELIZABETH ERIN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Vascular mural cells in the development of the blood brain barrier
DIETLEIN, FELIX	BOSTON CHILDREN'S HOSPITAL	Defining the universal genomic language of hallmarks in tumor development
DRAGANOVA, ELIZABETH BENNETT	EMORY UNIVERSITY	Under Pressure: Biophysical Mapping of Herpesvirus Capsid Assembly and Genome Packaging
FARNUNG, LUCAS	HARVARD MEDICAL SCHOOL	Visualizing mechanisms at the intersection of chromatin, transcription, and epigenetics
FERNANDEZ-RUIZ, ANTONIO	CORNELL UNIVERSITY	How do animals learn the structure of their natural environment?
FURST, ARIEL LESA	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Protecting microbes so they can protect us
GAO, RUIXUAN	UNIVERSITY OF ILLINOIS AT CHICAGO	A biochemical approach towards subcellular, label-free molecular imaging
GAO, XIAOJING J	STANFORD UNIVERSITY	A Novel Class of Synthetic Receptors to Empower the Age of mRNA Therapies
GOLDSTEIN, RACHEL E	UNIV OF MARYLAND, COLLEGE PARK	Water Emergency Team (WET): Community-Driven Rapid Response Team to Evaluate Antibiotic-Resistant Bacteria Exposures and Household Environmental Health Risks from Sewer Overflows and Basement Flooding
GRIENBERGER, CHRISTINE	BRANDEIS UNIVERSITY	Unraveling the synaptic and circuit mechanisms underlying a plasticity-driving instructive signal
HOLEHOUSE, ALEX S	WASHINGTON UNIVERSITY	Uncovering the regulatory logic of gene expression encoded by disordered regions
JAYANT, KRISHNA	PURDUE UNIVERSITY	Massively scalable 3D electrophysiology and two-photon imaging in freely-moving animals
JOST, MARCO	HARVARD MEDICAL SCHOOL	Capturing, quantifying, and understanding combinatorial effects in small molecule signaling
KIM, CHRISTINA	UNIVERSITY OF CALIFORNIA AT DAVIS	Activity-dependent probes for spatially-defined proteomics
KO, JIN A	UNIVERSITY OF PENNSYLVANIA	Droplet-based Spatially Encoded Live Cell Digital Extraction
LEVINSON, CHERI ALICIA	LEVINSON, CHERI ALICIA	Innovations in Personalizing Treatment for Eating Disorders Using Idiographic Methods and the Impact of Personalization on Psychological, Physical, and Sociodemographic Outcomes
LI, JIAHE	NORTHEASTERN UNIVERSITY	Enzymatic and genetic strategies for targeting disease-associated microbial metabolites
LODATO, MICHAEL ANTHONY	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Spatial single-cell analysis of somatic mutation in human brain during aging and neurodegeneration
LORD, NATHAN DALE	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Decoding the Spatial Grammar of Developmental Signaling
LOVETT-BARRON, MATTHEW	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Functional maturation of neural circuits for biological motion perception and social engagement
MADDIPATI, RAVIKANTH	UT SOUTHWESTERN MEDICAL CENTER	Optogenetic engineering of tumor topography in native tissue environments
MARTIK, MEGAN LEE	UNIVERSITY OF CALIFORNIA BERKELEY	Reactivating regulatory programs for regeneration
MILLER, MICHAEL B	BRIGHAM AND WOMEN'S HOSPITAL	Illuminating neurodegenerative tauopathy from somatic genomic landscapes of single human brain cells
MUNJAL, AKANKSHI	DUKE UNIVERSITY	Multi-scale feedbacks for robust organ development
MUSAH, SAMIRA	DUKE UNIVERSITY	Harnessing stem cells and synthetic gene circuits to repair glomerular injury
ODONNELL, MICHAEL PATRICK	YALE UNIVERSITY	Molecular determinants of host-feeding manipulation and microbial colonization
PODGORSKI, KASPAR	ALLEN INSTITUTE	Measuring input-output operations of cortical neurons with large-scale neurotransmitter imaging
RAY, JOHN PHILIP	BENAROYA RESEARCH INST AT VIRGINIA MASON	Investigating Genetic and Epigenetic Control of T Cell Function in Autoimmunity
RIJO-FERREIRA, FILIPA	UNIVERSITY OF CALIFORNIA BERKELEY	Defining and Exploiting the Circadian Clocks in Malaria Parasites
RODRIGUEZ, NATALIA MARIA	PURDUE UNIVERSITY	Addressing Cervical Cancer Disparities Among People Experiencing Homelessness
SCHMITT, DANIELLE LYNANNE	UNIVERSITY OF CALIFORNIA LOS ANGELES	Imaging Spatiotemporal Regulation of Acetyl-CoA
SHYER, AMY ELIZABETH	ROCKEFELLER UNIVERSITY	Studying the cellular ecology of organ formation using a novel tissue reconstitution system
SINGH, PARAM PRIYA	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Decoding natural protective mechanisms during diapause and longevity to counter aging
SOLTANOLKOTABI, MAHDI	UNIVERSITY OF SOUTHERN CALIFORNIA	Reliable AI for Medical Image Reconstruction
STERN, SARAH	MAX PLANCK FLORIDA CORPORATION	Identifying neurons for interoception using simultaneous profiling of activity- and projection- specific populations
SZABLOWSKI, JERZY OLGIERD	RICE UNIVERSITY	Monitoring neuronal activity with a blood test - Released Markers of Activity (RMA)
TISON, GEOFFREY H	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	A physiologically-focused approach to training multi-modality AI algorithms in medicine
TOWERS, CHRISTINA G	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Tracking the Mechanisms of Adaptation to Autophagy Inhibition
VASAN, NEIL	COLUMBIA UNIVERSITY HEALTH SCIENCES	Base-Editing the Cancer Kinome to Enable Drug Discovery
VENKATESH, HUMSA	BRIGHAM AND WOMEN'S HOSPITAL	Unraveling Neural Circuitry in Peripheral Cancer Pathogenesis: From Local Innervation to Systemic Influences
VLASSAKIS, JULEA	RICE UNIVERSITY	Deep phenotyping of fusion oncoprotein-driven pediatric cancer metastasis with single-cell proteomics
WASHINGTON, PETER	UNIVERSITY OF HAWAII AT MANOA	Crowd-Powered Machine Learning to Diagnose ASD and ADHD in Adolescents from Digital Social Interactions
XIE, LIANGQI	CLEVELAND CLINIC LERNER COM-CWRU	Live-Cell Chromatin Imaging and Biology: Application to Extrachromosomal DNA
YADAV, AMOL P	INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS	Sensory Augmentation, Restoration, and Modulation Using a Spinal Neuroprosthesis
YU, XINZHU	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	Functional, Structural and Molecular Decoding of Astrocyte-Neuron Interaction
ZHOU, XIN	DANA-FARBER CANCER INST	Engineering programmable enzymes for proteome editing
ZHU, CHENXU	NEW YORK GENOME CENTER	Studying the Regulatory Dynamics with Single-cell Multiomics

2022 NIH Director's New Innovator Award (DP2)

RFA-RM-21-016

*Diversity Statement

PI Name	Institution Name	Title
ALAMBEIGI, FARSHID	UNIVERSITY OF TEXAS AT AUSTIN	A Novel Semi-Autonomous Surgeon-in-the-Loop In Situ Robotic Bioprinting System for Functional and Cosmetic Restoration of Volumetric Muscle Loss Injuries
AREY, RACHEL NICOLE	BAYLOR COLLEGE OF MEDICINE	Uncovering Brain-Wide Molecular Determinants of Individual Memory Performance Across Lifespan
BEYELER, MICHAEL	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Towards a Smart Bionic Eye: AI-Powered Artificial Vision for the Treatment of Incurable Blindness
BLAZECK, JOHN JAMES	GEORGIA INSTITUTE OF TECHNOLOGY	Synthetic Metabolism to Armor and Enhance a New Class of Cell Therapies
BUCKLEY, RACHEL FRANCES	MASSACHUSETTS GENERAL HOSPITAL	The Inactive X: Discovering Sex Genes That Influence Female Vulnerability to Alzheimers Disease
CASE, LINDSAY	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	New Insights Into the Molecular Regulation of Mechanotransduction
CHAN, MICHELLE	PRINCETON UNIVERSITY	Building a Systematic, Comprehensive Mammalian Cell Fate Map
CHANG, CHI-LUN	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	Understanding Metabolism in Space and Time – Mechanistic Analysis of the Dynamic Spatial Organization of Metabolism
CHAVEZ, ALEJANDRO	COLUMBIA UNIVERSITY HEALTH SCIENCES	Methods to Rapidly Explore Combinatorial Diversity and Their Application to CRISPR-Cas9 Systems
CHEADLE, LUCAS M	COLD SPRING HARBOR LABORATORY	Neuroimmunological Insights Into Brain Development and Dysfunction: An Integrative Approach Focused on Microglial Dynamics
CHEN, XIAOYIN	ALLEN INSTITUTE	Unraveling the Developmental Logic of Cortical Long-Range Projections Using In Situ Sequencing-Based Neuroanatomy
CHRISTOPH, JAN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	AI-assisted Imaging and Prediction of Cardiac Arrhythmia Origins Using 4D Ultrasound
CLITES, TYLER R	UNIVERSITY OF CALIFORNIA LOS ANGELES	Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage
DELANEY, JOE R	MEDICAL UNIVERSITY OF SOUTH CAROLINA	Tumor Suppressor Vulnerability Conferred by Aneuploid Loss of Haploinsufficient Metallothionein Genes
DING, FANGYUAN	UNIVERSITY OF CALIFORNIA-IRVINE	Universally-Applicable RNA Mapping at Subcellular and Single-Base Resolution
ESCOBAR HOYOS, LUISA	YALE UNIVERSITY	Unleashing T-Cell Anti-Tumor Response Through Repair of Altered RNA Splicing and Antigen Mimicry Recognition
ESCOLANO, AMELIA	WISTAR INSTITUTE	Manipulating Epitope Immunodominance and Tracking B-cell-Antigen Interactions for Vaccine Design.
FEDER, ALISON F	UNIVERSITY OF WASHINGTON	A Phylodynamic Time Machine for Solid Tumors
FERGUSON, FLEUR MARCIA	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Chemical Control of Misfolded Protein Fate
FISHER, YVETTE E	UNIVERSITY OF CALIFORNIA BERKELEY	How Does Neuromodulation Shape the Fluidity of Spatial Working Memory?
GADAGKAR, VIKRAM	COLUMBIA UNIVERSITY HEALTH SCIENCES	The Female Songbird as a Novel Mechanistic Model for the Neural Basis of Social Evaluation
GARCIA QUIROZ, FELIPE	EMORY UNIVERSITY	Multifunctional Phase Sensors for Probing and Manipulation of Intracellular Biomolecular Condensates
GAUBLOMME, JELLERT	COLUMBIA UNIV NEW YORK MORNINGSIDE	Spacially Mapping of Pooled In Vivo CRISPR Screens in the Tumor Microenvironment
GOLDBERG, EMILY LAUREN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Discovering Mechanisms of Tissue-Resident Immune Aging
GRANGER, ADAM	BROAD INSTITUTE, INC.	High-Throughput Methods for Measuring Cortical Synaptic Connectivity at Single-Cell Resolution
GRUBAUGH, NATHAN DALE	YALE UNIVERSITY	Enhancing Dengue Virus Genomic Surveillance to Uncover Circulating Genetic Diversity
HA, GAVIN	FRED HUTCHINSON CANCER CENTER	Translating the Tumor Regulome from Cell-Free DNA for Precision Oncology
HRVATIN, SINISA	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Biology and Applications of Mammalian Hibernation-Like States
INAGAKI, HIDEHIKO	MAX PLANCK FLORIDA CORPORATION	A Novel Approach to Crack Neuronal Mechanisms that Shape Computations in the Brain
JIN, CHENGCHENG	UNIVERSITY OF PENNSYLVANIA	A Blueprint for Neutrophil Heterogeneity and Reprogramming in Cancer
JOGLEKAR, ALOK	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Signaling Via MHC: Engineering Immune Cells with New Capabilities
KLEINSTIVER, BENJAMIN PETER	MASSACHUSETTS GENERAL HOSPITAL	Scalable Development of Custom Genome Editing Technologies
KUANG, ZHENG	CARNEGIE-MELLON UNIVERSITY	Microbial Regulation of Mammalian Circadian Rhythms and the Sexual Dimorphism: From Metabolism to Immunity
KUNJAPUR, ADITYA MOHAN	UNIVERSITY OF DELAWARE	Boosting Efficacy of Oral Vaccine Candidates by Enabling Spore Display of Nitrated Antigens
KVON, EVGENY	UNIVERSITY OF CALIFORNIA-IRVINE	Deciphering the Mechanism of Long-Range Gene Regulation In Vivo
LAPINAITE, AUDRONE	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Engineering Novel Precision Genome Editing Tools
LI, ZHONGWEI	UNIVERSITY OF SOUTHERN CALIFORNIA	The Synthetic Kidney: A Revolutionary Solution for the Shortage of Kidneys for Transplantation
LIM, CI JI	UNIVERSITY OF WISCONSIN-MADISON	Unraveling the Telomere Black Box: A New Single-Molecule Approach to Define the Telomere Chromatin Landscape and its Functional Mechanisms
MAKINSON, CHRISTOPHER DONALD	COLUMBIA UNIVERSITY HEALTH SCIENCES	Unlocking the Postnatal Human Brain Using Activity Augmented Organoids
MANSOOR, STEVEN ELIAS	OREGON HEALTH & SCIENCE UNIVERSITY	Elucidation of P2X7 Receptor Signaling and Development of Novel Small Molecule and Aptamer Ligand Therapies
MCKENNA, AARON H	DARTMOUTH COLLEGE	Annotated Lineage Trees of Murine Development
MCKINLEY, KARA LAVIDGE	HARVARD UNIVERSITY	Life History of the Menstruating Uterus
MONK, ELLIS	HARVARD UNIVERSITY	The Optics of Health: Race Skin Tone Minority Health and Health Disparities in the U.S.
MOSALAGANTI, SHYAMAL	UNIVERSITY OF MICHIGAN AT ANN ARBOR	In-Situ Architecture of Membrane Contact Sites Mediating Organelle Fission
MOUSAVI, MARAL	UNIVERSITY OF SOUTHERN CALIFORNIA	Building a Two-Way Communication System: Bio-Orthogonal Superhydrophobic Nanoparticles for Controlled Stimulation and Real-Time Sensing of Neurotransmitters
NATHAVITHARANA, RUVANDHI	BETH ISRAEL DEACONESS MEDICAL CENTER	THWART-TB: Testing Health Workers At Risk to Advance Our Understanding of TB Infection
NIA, HADI TAVAKOLI	BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)	Probing Functioning Lung at the Cellular Resolution in Health and Disease
NIEPA, TAGBO HERMAN ROLAND	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Designing A High-Throughput Platform to Bioprospect the Human Microbiome and Manipulate Its Interplay with Host Environments
OKAFOR, C DENISE	PENNSYLVANIA STATE UNIVERSITY, THE	Improving Drug Design to Eliminate Side Effects: From Computational to Animal Models
PEARL, REBECCA L	UNIVERSITY OF FLORIDA	Transdiagnostic Intervention to Reduce Internalized Health-Related Stigma
PONCE, CARLOS RAMON	HARVARD MEDICAL SCHOOL	Defining Mechanisms for Natural Vision in the Primate Brain with Machine Learning
RAJ, BUSHRA	UNIVERSITY OF PENNSYLVANIA	Genomic Tools for Massively Parallel Recording of Signaling Activity at Cellular Resolution in a Brain-Wide Manner
RISCA, VIVIANA I	ROCKEFELLER UNIVERSITY	Cross-Regulation Between Loop Extrusion, Chromatin Fiber Structure and Chromatin-Associated RNAs
ROUSKIN, SILVIA	HARVARD MEDICAL SCHOOL	Constructing the Nest - Understanding the Mechanisms of Nidoviridae RNA Genomes Transcription and Recombination
SANULLI, SERENA	STANFORD UNIVERSITY	Harnessing the Chromatin Conformational Code for Epigenetic Regulation
SARKAR, DEBLINA	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Circulatronics: A New Paradigm for Biomedical Implants
SCHOENEBERG, JOHANNES	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Decode Mitochondrial Morphology Dynamics to Predict Cell Fate Decisions
SEN, DEBATTAMA RAI	MASSACHUSETTS GENERAL HOSPITAL	Dissecting the Enhancer Logic Governing Immune Cell Fate Decisions
SHI, XIAOYU	UNIVERSITY OF CALIFORNIA-IRVINE	Gel-based Optical-isolation Single-Cell 3D Spatial Multiomics
SKYLAR-SCOTT, MARK A	STANFORD UNIVERSITY	Trillion Cell Culture to Fuel Organ Biofabrication
SMEETON, JOANNA MARJORIE	COLUMBIA UNIVERSITY HEALTH SCIENCES	Deciphering Multi-Dcale Fifferentiation and Patterning Cues Driving Whole Craniofacial Joint Regeneration
SOZEN, BERNA	YALE UNIVERSITY	Deciphering Principles of Human Embryonic Patterning in Development and Disease
STAVISKY, SERGEY	UNIVERSITY OF CALIFORNIA AT DAVIS	Understanding and Restoring Speech Production Using an Intracortical Brain-Computer Interface
TE VELTHUIS, AREND JAN	PRINCETON UNIVERSITY	Structure and Dynamics of RNA Elements Regulating Viral Aberrant RNA Synthesis
THYME, SUMMER B	UNIVERSITY OF ALABAMA AT BIRMINGHAM	Defining the Chemical Perturbome of Neural Development and Activity
UHLER, CAROLINE	BROAD INSTITUTE, INC.	Causal Representation Learning for the Spatial Analysis of Transcriptomic and Imaging Data in Tissue Contexts
VAN VALEN, DAVID A	CALIFORNIA INSTITUTE OF TECHNOLOGY	Unraveling the Genetic Basis of Cellular Behaviors with Deep Learning and Imaging-Based Reverse Genetics
WANG, CHAO	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Integrated Nano-Opto-Fluidic System on Sapphire Towards Single-Molecule Protein Sequencing
WANG, SIHONG	UNIVERSITY OF CHICAGO	Immunocompatible Electronic Polymers and Devices for Implantable Sensors and Stimulators that Resist Foreign-Body Responses
WANG, WENJING	UNIVERSITY OF MICHIGAN AT ANN ARBOR	New Classes of Optogenetic and Chemogenetic Tools with a Feedback Control
WEEKS, AMY M	UNIVERSITY OF WISCONSIN-MADISON	Post-Translational Modification Proteomics in 4D: Chemoenzymatic Tools to Map the Dynamic Spatial Organization of Eukaryotic Signaling Pathways
WHITELEY, AARON THOMAS	UNIVERSITY OF COLORADO	Deciphering the Crosstalk Between Bacteria and Their Mammalian Hosts
YOUNG, AARON JOHN	GEORGIA INSTITUTE OF TECHNOLOGY	A New Framework for Self-Adaptive Artificial Intelligence to Personalize Assistance for Patients Using Robotic Exoskeletons and Prostheses

2021 NIH Director's New Innovator Award (DP2)

RFA-RM-20-012

*Diversity Statement

PI Name	Institution Name	Title
ABDELFATTAH, AHMED	BROWN UNIVERSITY	Lighting Up the Brain: Optogenetic Tools to Record, Trace, and Manipulate Brain Circuits at Cellular Resolution
ABU-REMAILEH, MONTHER	STANFORD UNIVERSITY	Innovations and Mechanisms in Tumor Subcellular Metabolism
AHARONI, DANIEL	UNIVERSITY OF CALIFORNIA LOS ANGELES	Developing Long-Term Neuro-Behavioral Recording and Real-Time Processing Platforms for Naturally Behaving Animals
ALHADEFF, AMBER L	MONELL CHEMICAL SENSES CENTER	Harnessing Sensory Food Circuits to Influence Feeding Behavior
BACKUS, KERIANN MARIE	UNIVERSITY OF CALIFORNIA LOS ANGELES	A Systems-Level Approach to Decipher the Protein Interactome
BLOSNICH, JOHN RUDOLPH	UNIVERSITY OF SOUTHERN CALIFORNIA	Shifting Suicide Prevention Paradigms: Looking Beyond Clinical Settings
BRIGIDI, GIAN-STEFANO	UNIVERSITY OF UTAH	Decoding Neuronal Activity History at the Genome Through the Spatially Segregated Inducible Transcription Factors
BROWN, BREANN	VANDERBILT UNIVERSITY	Off the Beaten Path(Way): Spatiotemporal Investigation of Protein Assemblies Controlling Mitochondrial Metabolism
CANZIO, DANIELE	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	How Do Neurons Recognize Self from Non-Self?
CAO, JUNYUE	ROCKEFELLER UNIVERSITY	Single Cell Dynamics on a Whole Organism Scale
CHOI, PETER S	CHILDREN'S HOSP OF PHILADELPHIA	Exploring Hidden Determinants of Splicing with Genome-Targeted Proximity Labeling
ENGLISH, JUSTIN G	UNIVERSITY OF UTAH	Directed Evolution of Cell-Type Specific On-Demand Signaling Control Systems
FILBIN, MARIELLA GRUBER	DANA-FARBER CANCER INST	How the 3D Architecture of the Brain Shapes Cancer Cell Fate Decisions
FLEISCHER, CANDACE C	EMORY UNIVERSITY	A Novel Framework for Quantifying Metabolic Brain Health
GOMES, ANA	H. LEE MOFFITT CANCER CTR & RES INST	Aging as a Selective Pressure that Drives Tumor Progression
GONG, YI-NAN	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Necrotic Survivors and Plasma Membrane Integrity Signaling
GORODETSKY, ALON A	UNIVERSITY OF CALIFORNIA-IRVINE	Cephalopod-Inspired Bioelectronic Control of Cellular Signaling
HEYS, JAMES GERARD	UNIVERSITY OF UTAH	Uncovering the Neural Circuit and Synaptic Mechanisms Underlying Interval Timing
HOSSEINZADEH, PARISA	UNIVERSITY OF OREGON	A Data-Driven Approach Towards Generation of Permeable Peptide Therapeutics
HU, CHI-KUO	STATE UNIVERSITY NEW YORK STONY BROOK	Understanding Diapause and Its Ability to Suspend and Preserve Life
JACKSON, RUAIDHRI	HARVARD MEDICAL SCHOOL	Illuminating the Immune Systems Genomic Dark Matter: Functionally Annotating the Hidden Translatome
KASOWSKI, MAYA	STANFORD UNIVERSITY	A Single Cell Pooling Framework for Deciphering the Regulatory Wiring of Allergy in Pathophysiologic Contexts
KEMALADEWI, DWI UTAMI	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Implications of Genetic Diversity in Muscular Dystrophy
KORB, ERICA MEGAN	UNIVERSITY OF PENNSYLVANIA	The Epigenetic Encoding of Learning and Memory
KRANZUSCH, PHILIP J	DANA-FARBER CANCER INST	Discovery of cGAS-Like Signaling Enzymes in Innate Immunity and Disease
KRASILEVA, KSENIA V	UNIVERSITY OF CALIFORNIA BERKELEY	Cross-Kingdom Health: Evolution of Innate Immune Receptors and Their Targets
LAIDLAW, BRIAN	WASHINGTON UNIVERSITY	Enhancing the Antiviral Memory B Cell Response
LEE, JOHN KYUNG	FRED HUTCHINSON CANCER RESEARCH CENTER	Uncovering Diverse Genotype-Phenotype Relationships in Prostate Cancer
LI, GUANG	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Generation of Four-Chambered Hearts Through Organoid Fusions
LI, PULIN	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Systematic Reconstruction of Epithelial-Mesenchymal Communication in Organ Development
MADIGAN, CRESSIDA ARIANNA	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Bacterial Disruption of Neuroimmune Pathways in a Transparent Brain
MAJZNER, ROBBIE G	STANFORD UNIVERSITY	Hijacking the T Cell Machinery for Logic-Gated CAR T Cell Control
MIHAYLOVA, MARIA M	OHIO STATE UNIVERSITY	Determining Age-Dependent Metabolic Changes in Tumors and Their Microenvironment
MIR, MUSTAFA AIZED HASAN	CHILDREN'S HOSP OF PHILADELPHIA	Quantifying the Dynamics of Gene Regulation and Nuclear Organization During Embryogenesis
MOK, WENDY W K	UNIVERSITY OF CONNECTICUT SCH OF MED/DNT	Mapping Polymicrobial Interactions that Modulate Antibiotic Persistence
MURTHY, SWETHA	OREGON HEALTH & SCIENCE UNIVERSITY	A New Approach to Study Mechanically Activated Ion Channels
NEAL, JAMES THOMAS	BROAD INSTITUTE, INC.	Optical Functional Genomics
ORVEDAHL, ANTHONY W	WASHINGTON UNIVERSITY	Alveolus as Incubator: Functional Genomic Dissection of the Host Response to SARS-CoV-2 Infection.
OUDIN, MADELEINE JULIE	TUFTS UNIVERSITY MEDFORD	Defining and Exploiting the Neuronal Identity of Cancers
PANDARINATH, CHETHAN	EMORY UNIVERSITY	Fusing Motor Neuroscience and Artificial Intelligence to Create Next-Generation Neural Prostheses
PERRY, JUSTIN S	SLOAN-KETTERING INST CAN RESEARCH	Rethinking the "Quiet" Nature of Apoptotic Cell Clearance
PLESA, CALIN	UNIVERSITY OF OREGON	Proteome Scale Multiplexed Generation of Recombinant Antibodies
QUON, GERALD	UNIVERSITY OF CALIFORNIA AT DAVIS	Linking Genetics to Cellular Behavior and Disease Via Multimodal Data Integration
RAMANI, VIJAY	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Single-Cell Chemical Transcriptomic Dissection of an Essential Transcription Factor Network
RITCHWOOD, TIARNEY D	DUKE UNIVERSITY	Community-Academic Partnerships to Address COVID-19 Inequities Within African American Communities
SAELICES GOMEZ, LORENA	UT SOUTHWESTERN MEDICAL CENTER	Closing the Gap Between Structural Biology and Translational Science for Amyloid Diseases
SHARMA, NIKHIL	COLUMBIA UNIVERSITY HEALTH SCIENCES	The Cellular and Molecular Mechanisms Underlying Nociception and Pain
SIMUNOVIC, MIJO	COLUMBIA UNIV NEW YORK MORNINGSIDE	Synthetic Organogenesis: New Paradigms in Reconstituting Human Organ Development In Vitro
SMITH, CLARE MARGARET	DUKE UNIVERSITY	Dissecting the Genetic Basis of Protective Immunity to Tuberculosis in Diverse Hosts
SMITH, ZACHARY DYLAN	YALE UNIVERSITY	Epigenetic and Environmental Impact on Early Embryonic Development
SUN, BRYAN	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Insights to Noncoding Disease Variants Using Mosaic Diseases
SUN, LU	UT SOUTHWESTERN MEDICAL CENTER	Molecular and Genetic Decoding of Neuron-Glial Interactions
VOS, SEYCHELLE MONQIUE	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Towards Fully Reconstituting Mammalian Transcription in a Test Tube
WAGNER, DANIEL E	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Mapping Cell Fate Flow and Feedback Control on Vertebrate Embryonic Landscapes
WAN, LILING	UNIVERSITY OF PENNSYLVANIA	Illuminating Transcriptional Condensates Using an Integrated Approach
WAN, WILLIAM N	VANDERBILT UNIVERSITY	Elucidating the Mechanisms of Viral Life Cycles Under Near-Native Conditions
WANG, XIAO	BROAD INSTITUTE, INC.	Single-Cell In Situ Analysis of RNA Modifications in Intact Tissues
WEAVER, JESSICA DIANE	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Immunosuppression-Free Transplantation Through Placental Mimicry
WENDLANDT, ALISON	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Late Stage Stereochemical Editing to Transform the Synthesis of Bioactive Molecules
WONG, YVETTE	NORTHWESTERN UNIVERSITY AT CHICAGO	The Dynamic Architecture of Living Cells: Uncovering Intra-Organelle Events at Nanoscale Levels
WU, NICHOLAS C	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	High-Throughput Identification of Antibody Features for Sequence-Based Epitope Prediction
YAN, JING	YALE UNIVERSITY	Tracking Single-Cell Gene Expression Heterogeneity and Its Consequences in Bacterial Biofilms
ZHAO, SHUANG	UNIVERSITY OF WISCONSIN-MADISON	Dynamic Molecular Evoluation of Treatment Resistant Cancer
ZHOU, JIAN	UT SOUTHWESTERN MEDICAL CENTER	Sequence Models of Genome Regulatory Architecture in 3D

2020 NIH Director's New Innovator Award (DP2)

RFA-RM-19-006

*Diversity Statement

PI Name	Institution Name	Title
ACOSTA, VICTOR MARCEL	UNIVERSITY OF NEW MEXICO	Nuclear Magnetic Resonance Microscope Based on Diamond Quantum Sensors
ALLEN, ALICIA M	UNIVERSITY OF ARIZONA	Hormonal Response to Infant Caregiving: A Novel Strategy to Break the Opioid Relapse Cycle During the Postpartum Period
ANWAR, MEKHAIL	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Implantable Nanophotonic Sensors for In Vivo Immunoresponse
ARONOV, DMITRIY	COLUMBIA UNIVERSITY HEALTH SCIENCES	Using a Specialized Behavior to Study the Neural Mechanisms of Episodic Memory
BAO, HUAN	SCRIPPS FLORIDA	Developing Next-Generation Nanodiscs for the Study and Modulation of Membrane Proteins
BASU, ANINDITA	UNIVERSITY OF CHICAGO	Profiling Transcriptional Heterogeneity in Microbial Cells at Single Cell Resolution and High-Throughput Using Droplet Microfluidics
BIRNBAUM, MICHAEL	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Repertoire-Scale T Cell Antigen Identification Via Peptide-Mhc Lentivirus Display
CONSTANTINOPLE, CHRISTINE MARIE	NEW YORK UNIVERSITY	Neural Circuit Mechanisms of Arithmetic for Economic Decision-Making
CORDER, GREGORY	UNIVERSITY OF PENNSYLVANIA	Harnessing Cortical Neuromodulation to Disrupt Pain Perception
DASGUPTA, SUBHAMOY	ROSWELL PARK CANCER INSTITUTE CORP	Decoding the Nuclear Metabolic Processes Regulating Gene Transcription
DEMAZUMDER, DEEPTANKAR	UNIVERSITY OF CINCINNATI	Eavesdropping on Heart-Brain Conversations During Sleep for Early Detection and Prevention of Fatal Cardiovascular Disease
FALKNER, ANNEGRET LEA	PRINCETON UNIVERSITY	Generating Pro-Resilient States Through Individualized Circuit Read-Write Therapeutics
FONT-BURGADA, JOAN	RESEARCH INST OF FOX CHASE CAN CTR	New Tools for Understanding Metastasis Through Tissue Resident Cells: Enabling an Extensive Medicine Strategy for Metastatic Disease
FRIED, STEPHEN DAVID	JOHNS HOPKINS UNIVERSITY	Watching Proteins Fold (or Misfold) In Vivo with Mass Spectrometry
GUO, FENG	INDIANA UNIVERSITY BLOOMINGTON	An Acoustofluidic Avidity Cytometer for Massive Parallel Profiling Single Autoreactive T Cell in Autoimmune Disease
HAI, AVIAD	UNIVERSITY OF WISCONSIN-MADISON	Achieving Direct Functional Imaging of Brain Electrophysiology: Nanofabricated Cell-Sized Electronic Sensors for Magnetic Resonance Imaging
HANSEN, ANDERS SEJR	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Dynamic Bottom-Up Dissection of Chromatin Looping and Gene Regulation
HAROUSH, KEREN	STANFORD UNIVERSITY	Unraveling Neuronal Circuits and Causal Underpinnings of Long Time-Scale Social Strategic Behaviors
HEKSTRA, DOEKE ROMKE	HARVARD UNIVERSITY	Identifying Principles of Protein Mechanics by Applying Force and Observing Motion
HULTMAN, RAINBO	UNIVERSITY OF IOWA	Electrical Connectomics: An Innovative Approach for Dissecting Brain Mechanisms Underlying Behavioral States
JAISWAL, SIDDHARTHA	STANFORD UNIVERSITY	Clonal Hematopoiesis in Human Aging and Disease
KAO, JONATHAN CHAU-YAN	UNIVERSITY OF CALIFORNIA LOS ANGELES	Next Generation Brain-Machine Interfaces Controlled Synergistically with Artificial Intelligence
KIM, SUNG SOO	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Neural Circuit Mechanisms Underlying Dynamic Stimulus Selection
KUZUM, DUYGU	UNIVERSITY OF CALIFORNIA, SAN DIEGO	E-Organoids: Functional Brain Organoids Co-Grafted with Transparent Microthreads
LARIMER, BENJAMIN M	UNIVERSITY OF ALABAMA AT BIRMINGHAM	Site-Specific Immune Cell Activation Detection for Improving Individualized Cancer Immunotherapy
LEE, EUNJUNG ALICE	BOSTON CHILDREN'S HOSPITAL	Mechanism for Endogenous Retroelements to Mimic Ancient Exogenous Identities in Aging and Diseased Human Tissue
LI, YANRAN	UNIVERSITY OF CALIFORNIA RIVERSIDE	Reprogramming Plant Perception for Novel Plant Natural Products Discovery
LIEBERMAN, TAMI D	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	An Evolutionary Framework for Identifying Determinants of Colonization in Human Microbiomes
LONGDEN, THOMAS A	UNIVERSITY OF MARYLAND BALTIMORE	Vascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and Disease
MILLER, MILES A	MASSACHUSETTS GENERAL HOSPITAL	Dissection of In Situ Myeloid Signaling Using Image-Guided Synthetic Control
MIRI, JOSEPH ANDREW	NORTHWESTERN UNIVERSITY	Combining Physiological, Genetic, and Computational Approaches with Naturalistic Climbing Behavior to Elucidate the Functional Elements of Descending Motor Control
MIRZADEH, ZAMAN	ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER	Hypothalamic Neurocircuit Remodeling to Treat Diabetes
NAIK, SHRUTI	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Decoding Microbe-Epithelial Stem Cell Interactions in Health and Disease
NORMAN, THOMAS MAXWELL	SLOAN-KETTERING INST CAN RESEARCH	Predictive Engineering of Cellular Transcriptional State
PAREDES, MERCEDES	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Gyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic Interventions
RACKI, LISA R	SCRIPPS RESEARCH INSTITUTE	Using Phage to Interrogate Bacterial Heterochromatin
ROCKLIN, GABRIEL JACOB	NORTHWESTERN UNIVERSITY AT CHICAGO	High-Throughput Discovery of Protein Energy Landscapes in Natural and Designed Proteomes
ROHNER, NICOLAS	STOWERS INSTITUTE FOR MEDICAL RESEARCH	Starvation Resistance and Resilience of Metabolic Dysfunction in Cavefish
SANCAK, YASEMIN S	UNIVERSITY OF WASHINGTON	Molecular Dissection of Mitochondria-Organelle Interactions
SCHMIDT, JENS CHRISTOPHER	MICHIGAN STATE UNIVERSITY	Single-Molecule Analysis of the DNA Damage Response in Living Cells
SHANECHI, MARYAM	UNIVERSITY OF SOUTHERN CALIFORNIA	A Novel Geometric Paradigm for Nonlinear Modeling and Control of Neural Dynamics
SHIPMAN, SETH LAWLER	J. DAVID GLADSTONE INSTITUTES	Engineered Mitochondria for Therapeutic Donation and Mitochondrial Genome Editing
SPEER, COLENSO MCNAUGHTON	UNIV OF MARYLAND, COLLEGE PARK	A Molecular Connectomics Platform for Multi-Scale Analysis of Activity-Dependent Synapse Development and Plasticity
STERNBERG, SAMUEL HENRY	COLUMBIA UNIVERSITY HEALTH SCIENCES	Leveraging Programmable Integrases for Human Genome Engineering
STITES, EDWARD C	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Systems Approaches for Opening Therapeutic Windows
TAKEBE, TAKANORI	CINCINNATI CHILDRENS HOSP MED CTR	Engineering Multi-Organs in a Dish
WANG, KAIHANG	CALIFORNIA INSTITUTE OF TECHNOLOGY	Megabase Scale Genome Engineering and Synthesis in Mammalian Cells
WEI, LU	CALIFORNIA INSTITUTE OF TECHNOLOGY	Super-Resolution Chemical Imaging for Biomedicine
WHITE, KATHARINE ALICE	UNIVERSITY OF NOTRE DAME	Roles for Increased Intracellular pH and Heterogeneity in Cancer
WU, XUEBING	COLUMBIA UNIVERSITY HEALTH SCIENCES	Genome-Wide Studies of the Noncoding Functions and Mechanisms of Human mRNAs
YAN, KELLEY	COLUMBIA UNIVERSITY HEALTH SCIENCES	Directing Cell Fate Along the Intestinal Enteroendocrine Lineage
YE, LI	SCRIPPS RESEARCH INSTITUTE	Modulating Somatosensory Network to Target Metabolic Diseases
ZHU, BOKAI	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Decoding The Regulation and Functions of Mammalian 12h-Clock

2019 NIH Director's New Innovator Award (DP2)

RFA-RM-18-008

*Advisory Committee to the NIH Director Working Group Findings

PI Name	Institution Name	Title
AKBARI, OMAR SULTAN	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Development of Synthetic Viral Circuitry to Regulate Viruses in Mosquito Disease Vectors
BEIER, KEVIN T	UNIVERSITY OF CALIFORNIA-IRVINE	Sculpting the Brain: High-Resolution Spatiotemporally-Controlled Modulation of Memories
BEYDER, ARTHUR	MAYO CLINIC ROCHESTER	Does the Gut Have a Sense of Touch?
BOHORQUEZ, DIEGO V	DUKE UNIVERSITY	Reversing Autism Linked Behaviors from the Gut
BUENROSTRO, JASON DANIEL	HARVARD UNIVERSITY	Single-Cell Epigenomic and Cellular Plasticity
BULLER, ANDREW	UNIVERSITY OF WISCONSIN-MADISON	Engineering In Vivo Biomolecular Synthesis with Non-Standard Building Blocks
CAI, DENISE JADE	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	How Does the Brain Maximize Storage Capacity?
CARMONA-FONTAINE, CARLOS	NEW YORK UNIVERSITY	Decoding the Fundamental Mechanisms of Tumor Emergence and Evolution
CARVUNIS, ANNE-RUXANDRA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	From Non-Coding to Coding: Uncovering the Hidden Coding Potential of Non-Coding Sequences and Its Role in De Novo Gene Evolution
CHANG, RUI	YALE UNIVERSITY	Understand the Little Brain on the Heart: A Molecular and Functional Dissection of the Intrinsic Cardiac Nervous System
DAYEH, SHADI	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Bringing Light to Functional Mapping in Resective Neurosurgery
DEANS, TARA LYNN	UNIVERSITY OF UTAH	Engineered Platelets for the Targeted Destruction of Circulating Tumor Cells
DIONNE, JENNIFER A	STANFORD UNIVERSITY	Nano-Optical Reporters of Dynamic Mechanotransduction in the Immune System
DOWNING, TIMOTHY LAMONT	UNIVERSITY OF CALIFORNIA-IRVINE	Spatial Epigenomics: A New Framework for Overcoming Mechanical Heterogeneity in Solid Tumors
DUPAGE, MICHEL	UNIVERSITY OF CALIFORNIA BERKELEY	Engineering Precision Cancer Immunotherapy
EDLOW, BRIAN L	MASSACHUSETTS GENERAL HOSPITAL	A Connectome-Based Clinical Trial Platform to Promote Early Recovery of Consciousness After Traumatic Coma
FATTAHI, FARANAK	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Modeling Neurodegenerative Disease Manifestations in Human Enteric Neurons
GREER, PAUL LIEBERMAN	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Elucidating the Role of a Novel Family of Chemoreceptor in Alzheimers Disease
GUO, CHUN-JUN	WEILL MEDICAL COLL OF CORNELL UNIV	An Integrative and Generalizable Approach to Modulate Microbiota Small Molecules in the Host
GUPTA, RAJAT M	BRIGHAM AND WOMEN'S HOSPITAL	A Genetic Approach to Identify the Common Mechanisms of Vascular Disease
KLOXIN, APRIL M	UNIVERSITY OF DELAWARE	Unraveling Fibrosis with Dynamic Microenvironments and Molecular Tools
KOCHER, SARAH D	PRINCETON UNIVERSITY	What Makes - and Breaks - a Social Brain?
LEGANT, WESLEY R	UNIV OF NORTH CAROLINA CHAPEL HILL	Connecting the Dots Between Single Molecule Dynamics and Cell Differentiation
LEIFER, ANDREW MICHAEL	PRINCETON UNIVERSITY	Probing Brain-Wide Functional Connectivity During Behavior
LERNER, TALIA NEWCOMBE	NORTHWESTERN UNIVERSITY AT CHICAGO	How Early-Life Experiences Create Individual Variation in Dopamine Circuit Architecture: Understanding Risk for Psychiatric Disease
LEVY, MAAYAN	UNIVERSITY OF PENNSYLVANIA	Post-Biotic Interventions to Ameliorate Age-Related Inflammation
LI, HAN	UNIVERSITY OF CALIFORNIA-IRVINE	Engineering an Unnatural Redox Cofactor (Uredox) System for Efficient Biosynthesis of Medicines
LIAU, BRIAN	HARVARD UNIVERSITY	Mapping Structure-Activity Relationships of Chemical Inhibitors Via Genome-Editing
LUEDTKE, ALEX	UNIVERSITY OF WASHINGTON	High-Resolution Inference for Correlates of Vaccine Protection
MCCORMICK, TYLER	UNIVERSITY OF WASHINGTON	Big Data, Big Models, and Big Bias?: A Decision Making Framework for Vital Rate Estimates Based on Extrapolation
MOHIMANI, HOSEIN	CARNEGIE-MELLON UNIVERSITY	Discovering Novel Small Molecule Antibiotics from Complex Microbial Communities by Integrating Computational Mass Spectrometry and Metagenome Mining
MORIZANE, RYUJI	MASSACHUSETTS GENERAL HOSPITAL	Recreating Kidney Organogenesis In Vitro with Human Pluripotent Stem Cells
MUZUMDAR, MANDAR DEEPAK	YALE UNIVERSITY	Defining Tumor Cell and Host Adaptations in Cancer Progression
NIU, JIA	BOSTON COLLEGE	Development of Compact CRISPR Editors for Multiplexed Editing of Complex Gene Networks
O'CONNELL, LAUREN A	STANFORD UNIVERSITY	Dietary Tuning of Infant Social Communication
OLABISI, OPEYEMI AYODEJI	DUKE UNIVERSITY	A Human Stem Cell-Derived Podocyte Model for APOL1 Nephropathy
PALM, NOAH WOLCOTT	YALE UNIVERSITY	A Forward Chemical Genetic Screen to Illuminate the Dark Matter of the Bioactive Microbiota Metabolome
PERANTEAU, WILLIAM H	CHILDREN'S HOSP OF PHILADELPHIA	In Utero CRISPR-Mediated Gene Editing to Cure Congenital Monogenic Disorders
POLLEN, ALEXANDER A	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Establishing a Stem Cell Biology Platform for Decoding the Genetic Basis of Human Brain Specializations
POULOPOULOS, ALEXANDROS	UNIVERSITY OF MARYLAND BALTIMORE	Untangling the Biology of Brain Wiring: High-Throughput Innovations for Molecular Screening and Functional Targeting of Circuit Development In Vivo
PUA, HEATHER H	VANDERBILT UNIVERSITY MEDICAL CENTER	Extracellular RNA Communication in Lung Inflammation
RAKOFF-NAHOUM, SETH	BOSTON CHILDREN'S HOSPITAL	Positive Selection as a Host Mechanism to Control the Microbiome
RUNYAN, CAROLINE ANNE	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Communication Between Networks: Context, Inhibition, and Neuromodulation
SCHUG, ZACHARY	WISTAR INSTITUTE	The Multifaceted Role of Acetate in Cancer
SCHWARZ, LINDSAY A	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	Intersectional Strategies to Understand the Function of Diverse Neural Circuits
SHALEM, OPHIR	CHILDREN'S HOSP OF PHILADELPHIA	Direct and Rapid Control of Proteins at Scale
SHAO, SICHEN	HARVARD MEDICAL SCHOOL	Decoding Ribosome-Triggered Quality Control Mechanisms
SHARMA, UPASNA	UNIVERSITY OF CALIFORNIA SANTA CRUZ	Paternal Contributions to Offspring Health: Intergenerational Epigenetic Inheritance Via Sperm Small RNAs
SIMOES-COSTA, MARCOS	CORNELL UNIVERSITY	Spatial Control of Pattern Formation in Early Vertebrate Development
SMITH, CODY J	UNIVERSITY OF NOTRE DAME	An Integrative Approach to Elucidate Glial Diversity and Its Role in Brain Functionality
TAGLIABRACCI, VINCENT SCOTT	UT SOUTHWESTERN MEDICAL CENTER	Breathing Life into Dead Enzymes
THAISS, CHRISTOPH ALEXANDER	UNIVERSITY OF PENNSYLVANIA	A Conserved Function of Amyloid Proteins in Host-Microbiome Interactions
THEUNISSEN, THOROLD	WASHINGTON UNIVERSITY	Resolving Epigenetic Instability During Pluripotent State Transitions: A Roadmap for Exploiting the Biomedical Potential of Dynamic Human Stem Cell States
VEDANTHAM, VASANTH	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	A Regenerative Approach to Cardiac Pacing
VILLANI, ALEXANDRA-CHLOE	MASSACHUSETTS GENERAL HOSPITAL	Deciphering the Achilles Heel of Cancer Immunotherapy
VOORHEES, REBECCA MARIA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Protein Complex Assembly in the ER Membrane
WANG, SIYUAN	YALE UNIVERSITY	Building the 3D Genomic Regulatome
WON, HYEJUNG	UNIV OF NORTH CAROLINA CHAPEL HILL	Deciphering Cell-Type Specific Regulatory Landscape in Human Brain
YUEN, COURTNEY MINGMEN	BRIGHAM AND WOMEN'S HOSPITAL	New Approaches to Optimizing the Application and Measuring the Impact of Community-Based Tuberculosis Interventions
ZHANG, XIAOCHANG	UNIVERSITY OF CHICAGO	Single Cell Detection of Dynamic Protein-RNA Interaction

2018 NIH Director's New Innovator Award (DP2)

RFA-RM-17-006

*Commitment to Diversity

PI Name	Institution Name	Title
BOETTIGER, ALISTAIR	STANFORD UNIVERSITY	High Resolution Imaging of Genome Structure and Gene Regulation in Development
CARVILL, GEMMA LOUISE	NORTHWESTERN UNIVERSITY AT CHICAGO	Cell-Free DNA Sequencing Approaches to Define the Genetic Etiology of Unexplained Epilepsy
CHEN, JERRY L	BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)	Cracking Genetically Defined Neocortical Circuits across Learning and Behavior
CHEN, SIDI	YALE UNIVERSITY	High-Throughput In Vivo Genetics for Immunotherapy Target Discovery
CHEVRIER, NICOLAS	UNIVERSITY OF CHICAGO	Building a Predictive Framework for Adjuvant Combinatorics in Vaccine Development
CHUNG, EUN JI	UNIVERSITY OF SOUTHERN CALIFORNIA	A Revolutionary Approach for Polycystic Kidney Disease: Oral Nanotherapeutics
DENNIS, MEGAN Y	UNIVERSITY OF CALIFORNIA AT DAVIS	The Function of Duplicated Genes in Human Brain Evolution and Disease
DONALDSON, ZOE REBECCA	UNIVERSITY OF COLORADO	Neuronal Basis of Social Motivation and the Failure to Adapt to Loss
DOULATOV, SERGEI	UNIVERSITY OF WASHINGTON	Uncovering Epigenetic Barriers to Hematopoietic Stem Cell Formation
DUTTON, RACHEL J	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Molecular Mechanisms that Shape Microbial Communities
EHRLICH, KATHERINE BABCOCK	UNIVERSITY OF GEORGIA	Innovative Approaches to the Study of Social Determinants of Health in Children
FEINBERG, EVAN HARRIMAN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	High-Resolution Neural Circuit Dissection with Controllers Locally Affecting Synaptic Partners (CLASP)
FLOOR, STEPHEN NICHOLAS	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	The Impact of Human RNA Diversity on Protein Production and Cell Fate
FREDERICK, KENDRA KING	UT SOUTHWESTERN MEDICAL CENTER	High Sensitivity NMR for Structure Determination of Neurodegenerative Disease Associated Protein Aggregates in Native Contexts
GALLEGO-PEREZ, DANIEL	OHIO STATE UNIVERSITY	Novel Nanoscale Approaches to Whole Tissue Reprogramming
GAWAD, CHARLES	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	Creating a Catalog of Cancer Clonotype Drug Sensitivities with Single-Cell Genome Sequencing
GILBERT, LUKE	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	A Genetic Interaction Map of the Human Nucleus
GONG, YIYANG	DUKE UNIVERSITY	Voltage Imaging Dissection of the Mammalian Cortex
GORDON, REYNA LEIGH	VANDERBILT UNIVERSITY MEDICAL CENTER	Biomarkers of Rhythmic Communication: Integrating Foundational and Translational Approaches
GUO, JUNJIE	YALE UNIVERSITY	Molecular and Cellular Determinants of RNA Repeat-Associated Properties
HARIADI, RIZAL FAJAR	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Nanoscale Reconstruction of Mechanical Systems Involved in Disease Pathogenesis
HUANG, JUN	UNIVERSITY OF CHICAGO	Molecular Mechanism of Natural Killer Cell Recognition
JAIN, RAJAN	UNIVERSITY OF PENNSYLVANIA	Deciphering Nuclear Lamina-Chromatin Organization in Cellular Competence and Cardiac Development
KAYSER, MATTHEW S	UNIVERSITY OF PENNSYLVANIA	Building Brains in Our Sleep: A Drosophila Larval Platform for Examining Sleep and Neurogenesis
KIM, JUSTIN	DANA-FARBER CANCER INST	Post-Translational Modification of Protein Surfaces
KING, KEVIN R	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Elucidating Cell Communication Networks During Tissue Inflammation, Fibrosis, and Regeneration
KWON, ESTER J	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Nanoscale Biomaterials for Targeted Repair in Traumatic Brain Injury
LANDAU, DAN	WEILL MEDICAL COLL OF CORNELL UNIV	Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution
LIU, SHIXIN	ROCKEFELLER UNIVERSITY	Probing Symmetry Breaking in Epigenetic Inheritance: From Single Molecules to Systems Biology
LOH, PO-RU	BRIGHAM AND WOMEN'S HOSPITAL	Revealing Somatic Genome Alterations and Their Clinical Sequelae: Ultrasensitive Computational Detection of Mosaic Structural Variants
MCBRIDE, CAROLYN SARAH	PRINCETON UNIVERSITY	Mapping the Combinatorial Olfactory Inputs that Drive Mosquito Host Attraction
MISHRA, PRASHANT	UT SOUTHWESTERN MEDICAL CENTER	Engineering Faithful Animal Models of Mitochondrial Disease
MITCHELL, MICHAEL J	UNIVERSITY OF PENNSYLVANIA	A Data-Driven Drug Delivery (4D) Platform for Probing and Treating the Chemoresistant Bone Marrow Microenvironment
MOORE, DARCIE LEANN	UNIVERSITY OF WISCONSIN-MADISON	The Mechanisms and Functional Role of the Asymmetric Segregation of Cellular Cargoes in Stem Cells
PATHAK, MEDHA M	UNIVERSITY OF CALIFORNIA-IRVINE	Building the Brain: How Mechanical Forces Shape Human Neural Development
RAMAN, SRIVATSAN	UNIVERSITY OF WISCONSIN-MADISON	Understanding Molecular Rules Governing Protein Allostery by Deep Mutational Scanning
ROCK, JEREMY MICHAEL	ROCKEFELLER UNIVERSITY	Towards a Molecular Understanding of Persistent Tuberculosis Infection
ROYBAL, KOLE T	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Engineering the Next-generation of Custom Immune Cell Therapies
RUDER, WARREN CHRISTOPHER	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Creating Magnetically Inducible Synthetic Gene Networks for Cell and Tissue Therapies
SAFDAR, NASIA	UNIVERSITY OF WISCONSIN-MADISON	Modelling Applications and Systems Engineering to Reduce Infections the MASTERI Study
SAGGAR, MANISH	STANFORD UNIVERSITY	Only Time Will Tell: A Computational Psychiatry Approach to Model Temporal Transitions in Brain Activity as a Lens Towards Developing Better Diagnostic Nosology for Psychiatric Illness
SCHARSCHMIDT, TIFFANY CRAWFORD	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Decoding and Harnessing Microbial Tuning of T Cell Responses in Early Life
SHEFFIELD, MARK E J	UNIVERSITY OF CHICAGO	Sub-Cellular Resolution Functional Imaging and Optogenetic Manipulation of Identified Memory Circuits During Behavior
SLETTEN, ELLEN MAY	UNIVERSITY OF CALIFORNIA LOS ANGELES	Bioorthogonal Host-Guest Chemistry for Tandem Imaging and Therapy
SPENCER, SABRINA LEIGH	UNIVERSITY OF COLORADO	Proliferation-Quiescence Control in Single Cells: Integration of Mitogen, Nutrient, and Stress Signaling
STEPHANOPOULOS, NICHOLAS	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Chemical Synthesis of G Protein-Coupled Receptors Using Sequential DNA-Templated Reactions
TADROSS, MICHAEL R	DUKE UNIVERSITY	Interrogating Dynamics of Whole-Brain Volumes with Cell Type-Specific Pharmacology
TITOV, DENIS VASILIEVICH	UNIVERSITY OF CALIFORNIA BERKELEY	Genetically Encoded Tools for Manipulation of Metabolism In Vivo
TOMER, RAJU	COLUMBIA UNIV NEW YORK MORNINGSIDE	A Comparative Approach for Decomposing the Mammalian Brain Architectural Complexity
VARGAS-IRWIN, CARLOS	BROWN UNIVERSITY	Synergistic Effector/Environment Encoding: A New Perspective on Motor Cortex and Brain-Computer Interfaces
WATANABE, SHIGEKI	JOHNS HOPKINS UNIVERSITY	Reviving Electron Microscopy for Synaptic Cell Biology
WESOLOWSKI, AMY	JOHNS HOPKINS UNIVERSITY	Disease Emergence and Elimination: Using Mobility Data to Inform Spatial Disease Dynamics
WHITEHEAD, KATHRYN A	CARNEGIE-MELLON UNIVERSITY	Fate, Function and Genetic Engineering of Breast Milk Cells for Infant Therapy
WRIGHT, ERIK SCOTT	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Uncovering Synergistic Antibiotic Cocktails with Comparative Genomics
XU, KE	UNIVERSITY OF CALIFORNIA BERKELEY	Intracellular Phase Separation at the Nanoscale: A Functional Super-Resolution Approach
YAMANAKA, NAOKI	UNIVERSITY OF CALIFORNIA RIVERSIDE	Membrane Steroid Hormone Transporters in Development and Reproduction
ZANDERS, SARAH ELIZABETH	STOWERS INSTITUTE FOR MEDICAL RESEARCH	Models of Selfishness: Molecular and Evolutionary Analyses of the Wtf Meiotic Drivers
ZHAO, YONGXIN	CARNEGIE-MELLON UNIVERSITY	Highly Multiplexed Nanoscale Imaging Platforms for Profiling and Interrogation of Complex Diseases

2017 NIH Director's New Innovator Award (DP2)

RFA-RM-16-004

*Statement on Diversity

PI Name	Institution Name	Title
AJIJOLA, OLUJIMI A	UNIVERSITY OF CALIFORNIA LOS ANGELES	Multimodal Decoding of the Neural Circuitry of Sudden Death in Peripheral Ganglia
AZIM, EIMAN	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Neural Control of Skilled Movements: An Ethological Dissection of Genetically Tractable Mammalian Motor Circuits
BARMAN, ISHAN	JOHNS HOPKINS UNIVERSITY	Spectroscopy Assisted Mechano-Chemical Phenotype Recognition Nanoscope
BIRSOY, KIVANC	ROCKEFELLER UNIVERSITY	Dissecting Tumor Metabolic Heterogeneity In Vivo
BLACKBURN, JESSICA S	UNIVERSITY OF KENTUCKY	Harnessing Single Cell Technology to Define Self-Renewal in Normal and Malignant Stem Cells
BLAINEY, PAUL CLARK	BROAD INSTITUTE, INC.	Live Cell Transcriptomics
BRITO, ILANA LAUREN	CORNELL UNIVERSITY	Systems-Level Perspectives of Horizontal Gene Transfer Within the Human Microbiome
CALVE, SARAH	PURDUE UNIVERSITY	Defining the Mechanical Link that Unites the Musculoskeletal System During Limb Development
CAMBRONNE, XIAOLU ANG	OREGON HEALTH & SCIENCE UNIVERSITY	Gatekeepers of Mitochondrial NAD+
CHEN, ZHILEI	TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR	Artificial Ecology Sink as Prophylaxis Against Viral Infection
CHOI, JAEHYUK	NORTHWESTERN UNIVERSITY AT CHICAGO	Identifying Mechanisms Governing T Cell Diversity
COLLINS, SEAN RYAN	UNIVERSITY OF CALIFORNIA AT DAVIS	Rewiring Control of Leukocyte Motility for Therapeutic Application
CORN, JACOB ELLERY	UNIVERSITY OF CALIFORNIA BERKELEY	Discovering Mechanisms that Regulate Organelle Autophagy
DE VLAMINCK, IWIJN	CORNELL UNIVERSITY	Precision Monitoring of Kidney Transplants Via Single-Cell and Single-Molecule Sequencing
DELGOFFE, GREG M	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Exploring and Exploiting Metabolic Plasticity in Regulatory T Cells
DERBYSHIRE, EMILY R	DUKE UNIVERSITY	Enabling Host Processes for Defense Against Liver Stage Malaria Infection
ESVELT, KEVIN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Developing Powerful Daisy Drive Systems for the Precise Alteration of Local Populations
FARLEY, EMMA KIRSTEN	UNIVERSITY OF CALIFORNIA SAN DIEGO	Deciphering the Regulatory Principles Governing Enhancer Specificity
FEI, JINGYI	UNIVERSITY OF CHICAGO	Quantitative Imaging of Epitranscriptomic Regulation Mediated by RNA Modification
GAHARWAR, AKHILESH K	TEXAS ENGINEERING EXPERIMENT STATION	Mineralomics: Designing Mineral Based Therapeutics to Control and Direct Cell Function
GARCIA, HERNAN GUSTAVO	UNIVERSITY OF CALIFORNIA BERKELEY	Lighting Up the Central Dogma in Embryonic Development
GREEN, ALEXANDER ARTHUR	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Molecular Fuses for Real-Time, Label-Free, Multiplexed Imaging of RNAs in Living Cells
HIRES, SAMUEL ANDREW	UNIVERSITY OF SOUTHERN CALIFORNIA	New Approaches to Understanding Sensorimotor Learning and Perception
HOLLIS, EDMUND R	WINIFRED MASTERSON BURKE MED RES INST	Modulation of Cortical Networks, a New Approach to Spinal Cord Injury Rehabilitation
HON, GARY CHUNG	UT SOUTHWESTERN MEDICAL CENTER	Combinatorial Biology of Gene Regulation for Cellular Engineering
HWANG, SEUNGMIN	UNIVERSITY OF CHICAGO	Targeting by Autophagy Proteins for Anti-Tumor Immunity
IVANOVIC, TIJANA	BRANDEIS UNIVERSITY	Building Mechanistic Insight into Evolvability of Viral Cell-Entry Functions
KIM, YONGTAE	GEORGIA INSTITUTE OF TECHNOLOGY	Probing the Functional Heterogeneity of High-Density Lipoprotein Using Physiological Biomimicry
LI, BO	UNIV OF NORTH CAROLINA CHAPEL HILL	Mining Genomes for Synergistic Antibiotics
LI, LINGYIN	STANFORD UNIVERSITY	Chemical Biology of Innate Immunity for Treating Cancer and Autoimmunity
LINOS, ELENI	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Targeted Advertising for Cancer Prevention
MACOSKO, EVAN Z	BROAD INSTITUTE, INC.	Slide-Seq: High-Resolution In Situ Expression Profiling for Neuropathology
MALVANKAR, NIKHIL	YALE UNIVERSITY	Targeting Bacterial Infections by Imaging Electrical Interactions Between Host Surface Pathogens
MOELLERING, RAYMOND E	UNIVERSITY OF CHICAGO	Targeting Transcription with Synthetic Biologics
MOLOFSKY, ANNA V	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Coordinate Regulation of Neural Circuit Remodeling by Glia: A Prospective Molecular Approach
MORGAN, DANIEL J	UNIVERSITY OF MARYLAND BALTIMORE	Incorporating Bayesian Reasoning into Physician Testing and Treatment Decisions
OH, JULIA S	JACKSON LABORATORY	Metagenomes to Therapeutics: Defining the Rules for Engineering the Skin Microbiome
PANNIER, ANGELA K	UNIVERSITY OF NEBRASKA LINCOLN	Using Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell Therapies
RAJASETHUPATHY, PRIYA	ROCKEFELLER UNIVERSITY	Bridging the Gap from Genes to Circuits to Behavior in Understanding Cognitive Dysfunction
ROSE, SHERRI	HARVARD MEDICAL SCHOOL	Machine Learning for Health Outcomes and Quality of Care in Low-Income Populations
SAMUEL, BUCK SPARROW	BAYLOR COLLEGE OF MEDICINE	Microbial Programming of Host Physiology
SANJANA, NEVILLE	NEW YORK GENOME CENTER	In Situ Functional Genomics to UnderstandTranscriptional Regulation
SARMA, KAVITHA	WISTAR INSTITUTE	Epigenetic Regulation Through the Formation and Resolution of R Loops
SCHIETINGER, ANDREA	SLOAN-KETTERING INST CAN RESEARCH	Spatiotemporal Regulation of T Cell Fate Decisions in Cancer
SCHLAU-COHEN, GABRIELA	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Nanometer Distance Assay to Uncover Protein Dynamics
SHEEHAN, MICHAEL J	CORNELL UNIVERSITY	Encoding Knowledge in the Genome
SIEGRIST, MARY SLOAN	UNIVERSITY OF MASSACHUSETTS AMHERST	Chemical Detection of Mycobacterium tuberculosis Growth and Antibiotic Response during Infection
SLUSKY, JOANNA S	UNIVERSITY OF KANSAS LAWRENCE	Designed Beta-Strands for Inhibiting Efflux Pumps and Disabling Antibiotic Resistance
SUBRAMANIAN, RADHIKA	MASSACHUSETTS GENERAL HOSPITAL	A Versatile Platform for Reconstructing the Spatial Organization of Intracellular Signaling During Cell-Division
TRITSCH, NICOLAS XAVIER	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	A Novel Framework for the Functional Dissection of Motor Systems
VON MOLTKE, JAKOB	UNIVERSITY OF WASHINGTON	Sensing of Helminths by Tuft Cells
WAINGER, BRIAN JASON	MASSACHUSETTS GENERAL HOSPITAL	A Human Stem Cell-Derived Neuromuscular Junction Model for Amyotrophic Lateral Sclerosis
WU, HAO	UNIVERSITY OF PENNSYLVANIA	Charting Oxygen-Sensing Gene Regulatory Network in Cardiomyocytes Through Single-Cell Analysis and Epigenome Editing
YANG, HUANGHE	DUKE UNIVERSITY	Manipulating TMEM16F Lipid Scramblase to Understand the Transbilayer Phospholipid Transport Phenomenon
ZHENG, YUEBING	UNIVERSITY OF TEXAS AT AUSTIN	On-Chip Multiplexed Adhesion Frequency Assay for Measuring Receptor-Ligand Interactions on Cells

2016 NIH Director's New Innovator Award (DP2)

RFA-RM-13-007

PI Name	Institution Name	Title
AL-SADY, BASSEM	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Reconstructing Dynamic Epigenetic Genome Partitioning in Single Stem Cells
ANDREWS, JASON RANDOLPH	STANFORD UNIVERSITY	Congregate Air Sampling for Population-Based Detection of Tuberculosis
APOSTOLOU, EFFIE	WEILL MEDICAL COLL OF CORNELL UNIV	Defining the Role of Chromatin Architecture in Cell Fate Inheritance
BAUER, DANIEL EVAN	CHILDREN'S HOSPITAL CORPORATION	High-Throughput Discovery of Essential Noncoding Sequences for Erythropoiesis
BENDALL, SEAN CURTIS	STANFORD UNIVERSITY	Origins of Human Blood Lineages in Regenerative Medicine
BHATNAGAR, PARIJAT	SRI INTERNATIONAL	Self-Assembled Therapeutics with Spatiotemporal Resolution
BROHAWN, STEPHEN GRAF	UNIVERSITY OF CALIFORNIA BERKELEY	New Approaches to Understanding Biological Force Sensation
CHEN, IRENE A	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Understanding How Bacteriophages Affect Wound Ecologies and Developing New Tools to Harness Bacteria-Phage Interactions
CHIU, ISAAC MING-CHENG	HARVARD MEDICAL SCHOOL	Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota
CHUNG, KWANGHUN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Proteome-Driven Holistic Reconstruction of Organ-Wide Multi-Scale Networks
CRAWFORD, FORREST WRENN	YALE UNIVERSITY	Network-Based Epidemiology for Hidden and Hard-to-Reach Populations
CRUM, ALIA	STANFORD UNIVERSITY	Harnessing Mindset in 21st Century Healthcare
DUS, MONICA	UNIVERSITY OF MICHIGAN	The Role of Neuroepigenetics in Bidirectional Behavioral States
EGAN, ELIZABETH S.	STANFORD UNIVERSITY	Identifying Critical Erythrocyte Host Factors for Plasmodium falciparum Malaria
FORDYCE, POLLY MORRELL	STANFORD UNIVERSITY	Leveraging Spectral Encoding for High Dimensional Biological Multiplexing
GREER, ERIC LIEBERMAN	CHILDREN'S HOSPITAL CORPORATION	Characterization of DNA N6-Methyl Adenine and Its Role in Epigenetic Memory
GUO, SHANGQIN	YALE UNIVERSITY	Molecular Definition of Cancer Cell-of-Origin
HAMMOUD, SAHER SUE	UNIVERSITY OF MICHIGAN	Contributions of Sperm Chromatin to Development: A Myth or Reality?
JOKERST, JESSE VINCENT	UNIVERSITY OF CALIFORNIA SAN DIEGO	Therapeutic Drug Monitoring with a Wearable Ultrasound-Based Sensor
KHALIL, AHMAD SAMIR	BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)	Combatting Antibiotic Resistance with Synthetic Biology Technologies
KLINGE, SEBASTIAN	ROCKEFELLER UNIVERSITY	Trapping and Reconstituting Early Stages of Eukaryotic Ribosome Assembly
KOREN, AMNON	CORNELL UNIVERSITY	Personal Mutational Landscapes Encoded in Our DNA
KRALJ, JOEL MARK	UNIVERSITY OF COLORADO	Neuronal Electromics in Health and Disease
KUNDAJE, ANSHUL	STANFORD UNIVERSITY	Deep Learning Frameworks for Regulatory Genomics
KWONG, GABRIEL A	GEORGIA INSTITUTE OF TECHNOLOGY	Noninvasive and Predictive Biomarkers of Organ Transplant Rejection
LAGANOWSKY, ARTHUR D	TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR	Native Ion Mobility Mass Spectrometry Studies of Potassium Inward Rectifier Channels: Insight into Gating and Lipid Binding
LEAL, CECILIA	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	A New Paradigm in Nanomedicine: Can Structural Interiors of Nanoparticles Regulate Cellular Delivery?
MADHUR, MEENAKSHI SWAMINATHAN	VANDERBILT UNIVERSITY	Immunophenotyping of Human Hypertension Using Single Cell Multiplex Mass Cytometry to Identify Novel Therapeutic Targets
NAIR, NIKHIL UNNI	TUFTS UNIVERSITY MEDFORD	Metabolic Engineering in Humans: Altered Gut Microbes as a Therapeutic Platform
PENG, TIEN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Defining the Resident Mesenchymal Stem Cell Niche and Function In Vivo
PERERA, RUSHIKA MIRIAM	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Tracking Tumor Evolution Through In Vivo Organelle Profiling
PETRY, SABINE	PRINCETON UNIVERSITY	Building the Chromosome Segregation Machinery from Scratch
PURVIS, JEREMY	UNIV OF NORTH CAROLINA CHAPEL HILL	Controlling Stem Cell Fate Through Computational Modeling
ROGULJA, DRAGANA	HARVARD MEDICAL SCHOOL	Mechanisms of Arousal Threshold and Sleep Homeostasis
SAMUEL, MELANIE A	BAYLOR COLLEGE OF MEDICINE	Synaptic Reprogramming of Adult Neurons
SATIJA, RAHUL	NEW YORK GENOME CENTER	Learning the Metadata of the Cell with Single Cell Genomics
SCHMIDT, TIFFANY M.	NORTHWESTERN UNIVERSITY	Genetic Mapping of Visual Circuits
SLAVOV, NIKOLAI	NORTHEASTERN UNIVERSITY	Ribosome-Mediated Translational Regulation during Stem Cell Differentiation
STAUFFER, WILLIAM RICHARD	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Neural Correlates of Optimal Value Seeking in the Reward System
STEINHAUSER, MATTHEW	BRIGHAM AND WOMEN'S HOSPITAL	A New Modality to Image Tumor Metabolic Heterogeneity at Subcellular Resolution
STEVENS, KELLY R	UNIVERSITY OF WASHINGTON	Thermogenetic Activation of Engineered Tissue for Cardiac Repair
TIAN, BOZHI	UNIVERSITY OF CHICAGO	Silicon-Based Injectable Micro-Gels for Non-Genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular System
TOETTCHER, JARED E	PRINCETON UNIVERSITY	Harnessing Optogenetics to Diagnose and Therapeutically Rewire Cancer Cell Signaling
UNAL, ELCIN	UNIVERSITY OF CALIFORNIA BERKELEY	Illuminating Cellular Aging Pathways Through Gametogenesis
VILLA, ELIZABETH	UNIVERSITY OF CALIFORNIA SAN DIEGO	Opening Windows into the Cell: Revealing the Molecular Architecture of the Nuclear Periphery
WIITA, ARUN P.	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	In Vivo Monitoring of Oxidative Protein Folding Through Time-Resolved Quantitative Mass Spectrometry
XUE, WEN	UNIV OF MASSACHUSETTS MED SCH WORCESTER	CRISPR-Based Modular Therapy for Precision Medicine
YARTSEV, MICHAEL MOSHE	UNIVERSITY OF CALIFORNIA BERKELEY	The First Mammalian Model System for Studying Vocal Learning: A Behavioral and Neurophysiological Approach

2015 NIH Director's New Innovator Award (DP2)

RFA-RM-13-007

PI Name	Institution Name	Title
BARNES, ALEXANDER BENJAMIN	WASHINGTON UNIVERSITY	High-Sensitivity NMR at Room Temperature for Molecular Structure and Dynamics
BARSKI, ARTEM	CINCINNATI CHILDRENS HOSP MED CTR	Direct Epigenetic Reprogramming of T Cells
BASU, SANJAY	STANFORD UNIVERSITY	Cohort Filtering Models to Identify Social Program Effects on Health Disparities
BENNETT, ERIC JOSEPH	UNIVERSITY OF CALIFORNIA SAN DIEGO	Manipulating Protein Homeostasis Through Specialized Quality Control Ribosomes
BLOODGOOD, BRENDA L	UNIVERSITY OF CALIFORNIA SAN DIEGO	Charting a New Path for Rapid Signaling from the Synapse to the Nucleus
BRAR, GLORIA ANN	UNIVERSITY OF CALIFORNIA BERKELEY	Dissecting the Roles of Pervasive Short ORFs in Meiosis
COLE, FRANCESCA	UNIVERSITY OF TX MD ANDERSON CAN CTR	Mechanistic Derivation of Germ Line Mutation by Genome-Wide Mouse Tetrad Analysis
DONIA, MOHAMED ABOU	PRINCETON UNIVERSITY	Uncultivated Bacterial Symbionts of Humans: An Untapped Resource for Drug Discovery
DUMONT, SOPHIE	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Rewiring Cellular Architecture to Probe Mechanical Signal Processing at Kinetochores
FELDMAN, JESSICA LYNN	STANFORD UNIVERSITY	Mechanisms Controlling Microtubule Organization during Cell Differentiation
FENG, LIANG	STANFORD UNIVERSITY	Molecular Mechanism and Novel Therapeutic Strategy in Alzheimers Disease
GANGULY, KARUNESH	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Neuroprosthetic Control of an Anthropomorphic Exoskeleton in Tetraplegics
GERSHOW, MARC HERMAN	NEW YORK UNIVERSITY	Dissecting Olfactory Decision Making Using Optical Neurophysiology
GODULA, KAMIL	UNIVERSITY OF CALIFORNIA SAN DIEGO	In Vivo Glycan Engineering at the Cell-Matrix Interface to Control Stem Cell Fate
GOLDBERG, JESSE HEYMANN	CORNELL UNIVERSITY	Identifying Pathways for Motor Variability in the Mammalian Brain
IDOYAGA, JULIANA	STANFORD UNIVERSITY	Harnessing Human Dendritic Cell Subsets for the Design of Novel Immunotherapies
JAROSZ, DANIEL	STANFORD UNIVERSITY	Protein-Based Molecular Memories in Gene Regulation, Disease, and Development
JENSEN, JAKOB DANIEL	UNIVERSITY OF UTAH	Communal Feedback as an Innovative Alternative to Skin Self-Exam
JONIKAS, MARTIN CASIMIR	CARNEGIE INSTITUTION OF WASHINGTON, D.C.	Transforming Our Understanding of Eukaryotic Gene Functions Through Chemical Genetics in the Green Alga Chlamydomonas reinhardtii
KAMPMANN, MARTIN	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Rewiring of the Human Protein Homeostasis Network in Normal and Disease Contexts
KNIGHT, ZACHARY A.	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Sequencing Neural Circuits Controlling Thermoregulation
LIPOMI, DARREN J	UNIVERSITY OF CALIFORNIA SAN DIEGO	Stretchable, Biodegradable, and Self-Healing Semiconductors for Wearable and Implantable Sensors
LIU, CHANG C	UNIVERSITY OF CALIFORNIA-IRVINE	A High-Throughput Continuous Evolution System for In Vivo Biosensor Engineering
MOHAN, DEEPIKA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	A Novel Intervention to Make Heuristics a Source of Power for Physicians
MUNRO, JAMES B	TUFTS UNIVERSITY BOSTON	Structural Dynamics of Single Ebolavirus GP Molecules
PASZEK, MATTHEW J	CORNELL UNIVERSITY	Mechanobiology of the Cellular Glycocalyx
PHILLIPS-CREMINS, JENNIFER ELIZABETH	UNIVERSITY OF PENNSYLVANIA	Engineering 3-D Epigenome Topology with Light
PRAKASH, MANU	STANFORD UNIVERSITY	Mosquitoes Meet Microfluidics: Novel Tools for Ecological Surveillance of Insect-Borne Disease
PRASAD, ABHISHEK	UNIVERSITY OF MIAMI CORAL GABLES	Spinal Cord Neural Interface for Neuroprosthetics in a Primate Model
SCHWARTZ, GREGORY WILLIAM	NORTHWESTERN UNIVERSITY AT CHICAGO	Novel Circuit Mapping Strategies to Reverse Engineer the Retina
SCOTT, EVAN A	NORTHWESTERN UNIVERSITY	Development of Combination Immunotherapies for Atherosclerotic Inflammation
SEYEDSAYAMDOST, MOHAMMAD R	PRINCETON UNIVERSITY	Implementing Innovative Approaches to Access the Hidden Metabolomes of Bacteria
SHALEK, ALEX K	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Bottom - Up Profiling of Interacting Cellular Systems
SHOULDERS, MATTHEW DONALD	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Continuous Directed Evolution of Biomolecules in Human Cells for Medical Research
SPITALE, ROBERT C	UNIVERSITY OF CALIFORNIA-IRVINE	Cracking the RNA Localization Code
TRAPNELL, BRUCE COLSTON	UNIVERSITY OF WASHINGTON	Charting the Regulatory Topography of the Cell Differentiation Landscape with Single-Cell RNA-Seq
VASEGHI, MARMAR	UNIVERSITY OF CALIFORNIA LOS ANGELES	Cardiac Afferent Neurotransmission and Modulation of Ventricular Parasympathetic Control
WARDEN, MELISSA RHOADS	CORNELL UNIVERSITY	Imaging the Evolving Neural Circuit Dynamics of Depression
WHITED, JESSICA L	BRIGHAM AND WOMEN'S HOSPITAL	Leveraging Single-Cell Analysis to Elucidate Mechanisms of Vertebrate Limb Regeneration
YU, MIN	UNIVERSITY OF SOUTHERN CALIFORNIA	Developing Individualized Medicine Targeting Metastatic Breast Cancer Stem Cells
ZHANG, WENJUN	UNIVERSITY OF CALIFORNIA BERKELEY	In Situ Natural Product Labeling and Applications

2014 NIH Director's New Innovator Award (DP2)

RFA-RM-13-007

PI Name	Institution Name	Title
ABATE, ADAM R.	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Microfluidic Immunoprofiling for Biomarker Discovery in Rheumatoid Arthritis
ACAR, MURA	YALE UNIVERSITY	Quantitative Real-Time Characterization of Single-Cell Aging: From Phenotypes to Lifespan
ANDE, SATYANARAYANA	GEORGIA REGENTS UNIVERSITY CANCER CENTER	A Multifaceted Approach to Target Obesity
ANDERMANN, MARK L	BETH ISRAEL DEACONESS MEDICAL CENTER	Multiphoton Imaging of Thoughts of Food during Natural and Induced Hunger States
ANTHONY, ROBERT MCCULLOUGH	HARVARD MEDICAL SCHOOL	Glycoengineering In Vivo
ARDEHALI, REZA	UNIVERSITY OF CALIFORNIA LOS ANGELES	Exploring Heterogeneity of Cardiac Fibroblasts to Reverse Fibrosis
ARORA, MANISH	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	Reconstructing Fetal Toxicant Exposure and Homeostatic Disruptions
AYE, YIMON	CORNELL UNIVERSITY	Deconvoluting Redox Biology with Targeted Chemistry
BASSIK, MICHAEL C	STANFORD UNIVERSITY	Accelerating Drug Development and Repurposing Using Systematic Genetic Interaction Maps in Mammalian Cells
BONASIO, ROBERTO	UNIVERSITY OF PENNSYLVANIA	Studying Epigenetic Pathways in Brain Function and Social Behavior Using Ants
BORAD, MITESH	MAYO CLINIC ARIZONA	Oncolytic Virotherapy in Hepatocellular Cancer
BUSCHMAN, TIMOTHY J.	PRINCETON UNIVERSITY	Developing an Adaptive Cognitive Prosthetic to Replace Damaged Brain Regions
CANG, HU	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Ultra Sensitive Single Molecule Spectroscopy with Plasmonic Antennas
CISSE, IBRAHIM	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Imaging Transcription with Single Molecule Resolution in Live Mammalian Cells
COBEY, SARAH	THE UNIVERSITY OF CHICAGO	Modeling the Evolutionary Dynamics of Immunity to Influenza for Vaccine Development
GARNER, ETHAN CLARK	HARVARD UNIVERSITY	Dissecting Bacterial Cell Wall Synthesis Using In Vivo Single Molecule Tracking
GLICKFELD, LINDSEY L	DUKE UNIVERSITY	Context-Dependent Changes in Local and Long-Range Cortical Circuits
GOODWIN, ANDREW P.	UNIVERSITY OF COLORADO	Rapid, Multiscale Sensing Using Acoustic Detection Mechanisms
HALLEM, ELISSA ANYON	UNIVERSITY OF CALIFORNIA LOS ANGELES	The Neural Basis of Odor-Driven Behavior in Skin-Penetrating Parasitic Nematodes
HENDON, CHRISTINE P	COLUMBIA UNIV NEW YORK MORNINGSIDE	High Resolution Imaging of the Myocardium
HUH, DONGEUN	UNIVERSITY OF PENNSYLVANIA	Probing the Physics of Chronic Lung Disease Using Microphysiological Biomimicry
INGOLIA, NICHOLAS T	UNIVERSITY OF CALIFORNIA BERKELEY	Molecular Basis and Cellular Roles of Translational Regulation
JANELSINS, MICHELLE C	UNIVERSITY OF ROCHESTER	Clinical and Translational Approaches to Cognitive Impairments in Cancer
KADOCH, CIGALL	DANA-FARBER CANCER INSTITUTE	Reversing Oncogenic BAF Complex Structure & Function: New Therapeutic Approaches
KOSURI, SRIRAM	UNIVERSITY OF CALIFORNIA LOS ANGELES	Reverse Genomics of Regulatory Elements Governing Splicing
KREEGER, PAMELA K	UNIVERSITY OF WISCONSIN-MADISON	Analysis of How Quantitative Cellular Network Variation Impacts Tumor Progression
LANDER, GABRIEL CEDRIC	THE SCRIPPS RESEARCH INSTITUTE	Molecular Basis of Axonal Transport Described by High-Resolution 3D Imaging
LIN, CHENXIANG	YALE UNIVERSITY	Cell-Free Membrane Remodeling Guided by DNA Nano-Templates
LIPOVICH, LEONARD	WAYNE STATE UNIVERSITY	Life, Death, and Function: The Primate-Specific Long Non-Coding RNA Transcriptome
MARTIN, BRENT RANDALL	UNIVERSITY OF MICHIGAN	Multiscale Chemical Approaches to Map Oxidative Stress
MCALPINE, MICHAEL	UNIVERSITY OF MINNESOTA	3D Printed Nano-Bionic Organs
MURTHY, MALA	PRINCETON UNIVERSITY	How Does the Brain Solve the Pattern Recognition Problem?
NEUERT, GREGOR	VANDERBILT UNIVERSITY	Decoding the Noncoding Genome: lncRNA Dynamics and Function in Single Cells
ROSENBLUM, MICHAEL DAVID	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Functional Manipulation of Memory Regulatory T cells in Skin
ROUND, JUNE LOUISE	UNIVERSITY OF UTAH	Developing Therapies to Target the Microbiota
SCHOGGINS, JOHN W.	UT SOUTHWESTERN MEDICAL CENTER	Discovery of Antiviral Mechanisms in Bats
SFEIR, AGNEL	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Telomere-Independent Strategies to Protect Chromosome Ends
SIMON, MATTHEW DAVID	YALE UNIVERSITY	Integrating RNAs into Signaling Pathways by Engineering Covalent RNA Modification
STABENFELDT, SARAH E	ARIZONA STATE UNIVERSITY-TEMPE CAMPUS	Detecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out
TAGA, MICHIKO E	UNIVERSITY OF CALIFORNIA BERKELEY	Targeted Killing of Bacteria in Communities
TIAN, LIN	UNIVERSITY OF CALIFORNIA AT DAVIS	Fluorescent Biosensors for Imaging Neurotransmitters: Observing Synapses in Action
WAN, LEO Q.	RENSSELAER POLYTECHNIC INSTITUTE	Cell Chirality Based In Vitro Models for Embryonic Development and Abnormalities
WESTREICH, DANIEL J	UNIV OF NORTH CAROLINA CHAPEL HILL	From Patients to Policy: Innovative Epidemiology for Implementation Science
XU, RONG	CASE WESTERN RESERVE UNIVERSITY	Rapid Reverse Translational Drug Repositioning
YANG, LEI	UNIVERSITY OF PITTSBURGH	Toward Regeneration of Whole Bioartificial Human Heart
YANG, LILI	UNIVERSITY OF CALIFORNIA LOS ANGELES	Stem Cell-Engineered Invariant Natural Killer T Cells for Cancer Therapy
ZHANG, LIJIE GRACE	GEORGE WASHINGTON UNIVERSITY	A Novel 3D Bioprinted Smart Vascularized Nano Tissue
ZHAO, WEIAN	UNIVERSITY OF CALIFORNIA IRVINE	Mechano-Sensing Stem Cells to Study, Detect and Treat Cancer Metastases
ZONCU, ROBERTO	UNIVERSITY OF CALIFORNIA BERKELEY	Engineering Organelle Function to Rewire Cancer Cell Metabolism
ZONG, CHENGHANG	BAYLOR COLLEGE OF MEDICINE	Detecting the Onset of Genome Heterogeneity in Tumor at Single Cell Resolution

2013 NIH Director's New Innovator Award (DP2)

RFA-RM-12-016

PI Name	Institution Name	Title
ADESNIK, HILLEL	UNIVERSITY OF CALIFORNIA BERKELEY	New Optical Strategies to Unlock the Neural Basis of Perception
AHERN, JENNIFER	UNIVERSITY OF CALIFORNIA BERKELEY	A Rigorous System to Determine the Health Impacts of Policies and Programs
ALDRIDGE, BREE BEARDSLEY	TUFTS UNIVERSITY BOSTON	Quantitative Design of Multi-Drug Regiments for Tuberculosis
ATON, SARA J	UNIVERSITY OF MICHIGAN	Linking Network Activity and Intracellular Plasticity Mechanisms During Sleep-Dependent Memory Consolidation
BLISH, CATHERINE A	STANFORD UNIVERSITY	Harnessing Natural Killer Cell Memory to Fight Viruses
CRAWFORD, JASON MICHAEL	YALE UNIVERSITY	Cryptic Gut Bacterial Metabolites that Regulate Colorectal Cancer Formation
DAR, ARVIN	MOUNT SINAI SCHOOL OF MEDICINE	Targeting Ras-Dependent Cancers with a Chemical Switch for an Inactive Kinase
DEO, RAHUL CHANDRAKANT	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	Resolving Incomplete Penetrance in the Cardiomyopathies and Channelopathies
DIEHN, MAXIMILIAN	STANFORD UNIVERSITY	Developing a Genomic Approach for Cancer Screening
DVORIN, JEFFREY D	CHILDREN'S HOSPITAL CORPORATION	Essential Gene Discovery in the Malaria Parasite Plasmodium falciparum
ESSER-KAHN, AARON PALMER	UNIVERSITY OF CALIFORNIA IRVINE	Directing the Immune System via Polymeric Combinations of Molecular Signals
EVANS, SCOTT E	UT MD ANDERSON CANCER CTR	Inducible Epithelial Antiviral Resistance to Prevent Asthma
FIEDLER, DOROTHEA	PRINCETON UNIVERSITY	Understanding Phosphate Metabolism in Cancer and Metastasis
FROST, ADAM	UNIVERSITY OF UTAH	Toward Atomic Resolution of Membranes and Membrane-Associated Machines
GANDHI, SUNIL	UNIVERSITY OF CALIFORNIA IRVINE	Rewiring Cortex Using Inhibitory Neuron Transplantation
GARTNER, ZEV JORDAN	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	Total Synthesis of the Human Mammary Gland
GRADINARU, VIVIANA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Neuromodulation and Neurodegeneration: The Missing Link and Mechanisms of Action
GREGG, ROBERT D	UNIVERSITY OF TEXAS DALLAS	Phase-Based Control of Locomotion for High-Performance Prostheses and Orthoses
HANSEN, SCOTT B	SCRIPPS FLORIDA	Molecular Mechanism of Mechanosensation
LAMB, TRACEY JANE	EMORY UNIVERSITY	The Development of Probiotic Yeast as an Inexpensive Vaccine Delivery Platform
LUCKS, JULIUS BEAU	CORNELL UNIVERSITY	A New High-Throughput Technology to Reveal the Dynamic Functional States of RNAs
MARR, LINSEY	VIRGINIA POLYTECHNIC INST AND ST UNIV	The Role of Pathogen-Environment Interactions in the Pandemic Potential of Influenza
MERRIKH, HOURA	UNIVERSITY OF WASHINGTON	Targeted Gene Evolution via Replication-Transcription Conflicts
MORTAZAVI, SEYED ALI	UNIVERSITY OF CALIFORNIA IRVINE	Comparative Analysis of the 4D Encoding of Regulatory Networks in Stem Cells
O'CONNELL, RYAN	UNIVERSITY OF UTAH	Utilizing TALEN Technology to Regulate Human microRNAs
ONNELA, JUKKA-PEKKA	HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)	Using Mobile Phones for Social and Behavioral Sensing of Mood Disorder Patients
PETERSEN, CHRISTIAN	NORTHWESTERN UNIVERSITY	Regulatory Circuits Controlling Regenerative Growth
PEYTON, SHELLY R	UNIVERSITY OF MASSACHUSETTS AMHERST	Tissue-Specific Stem Cells and Breast Cancer Tissue Tropism
RUTA, VANESSA	ROCKEFELLER UNIVERSITY	Connecting Neural Plasticity to Learning and Memory
SAHIN, OZGUR	COLUMBIA UNIV NEW YORK MORNINGSIDE	Novel Sub-Cellular Chemical and Mechanical Nanoimaging
SANJABI, SHOMYSEH	J. DAVID GLADSTONE INSTITUTES	Characterizing HIV Latent Reservoir In Vivo
SATTELY, ELIZABETH SUSAN	STANFORD UNIVERSITY	Liberation of Plant Nutrients by the Gut Microbiota
SAVAGE, DAVID FRANK	UNIVERSITY OF CALIFORNIA BERKELEY	Fluorescent Biosensors for Metabolite Imaging in Live Cells
SEANDEL, MARCO	WEILL MEDICAL COLL OF CORNELL UNIV	Clonal Competition in Stem Cells as a Driver of Paternal Age Effect Diseases
SIVARAMAKRISHNAN, SIVARAJ	UNIVERSITY OF MICHIGAN	The Kinase Toolbox: Mapping the Spatial and Temporal Regulation of Cell Signaling
TAYLOR, DEREK JAMES	CASE WESTERN RESERVE UNIVERSITY	Induction of Cancer Cell Death by Selective DNA Misincorporation
TISCHLER, ANNA DEGRAFF	UNIVERSITY OF MINNESOTA	High-Throughput Identification of Mycobacterium tuberculosis Persistence Mechanism
TYE, KAY MAXINE	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
WHITE, RICHARD MARK	SLOAN-KETTERING INST CAN RES	Evolutionary Dynamics of Melanoma Metastasis
WONG, WILSON	BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)	Synthetically Reengineered T Cells as the Next Generation of Smart Cancer Therapy
ZHENG, YING	UNIVERSITY OF WASHINGTON	A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis

2012 NIH Director's New Innovator Award (DP2)

RFA-RM-11-005

PI Name	Institution Name	Title
ALLEN, CHRISTOPHER DAVID	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Cellular Interactions in Asthma
AUGUSTE, DEBRA	HARVARD UNIVERSITY	Personalized Therapeutics for Inhibiting Breast Cancer Metastasis
BALSKUS, EMILY PATRICIA	HARVARD UNIVERSITY	Biocompatible Chemistry for In Vivo Metabolite Modification
BIVONA, TREVER G	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Discovery of Rational Companion Therapeutic Targets to Optimize Cancer Treatment
BONKOWSKY, JOSH LEITCH	UNIVERSITY OF UTAH	Trans-Cellular Activation of Transcription to Analyze Dopaminergic Axon Reorganization
BORENSTEIN, ELHANAN	UNIVERSITY OF WASHINGTON	A Computational Framework for Designing Microbiome Manipulation
BRANGWYNNE, CLIFFORD P	PRINCETON UNIVERSITY	Cell Growth Control by Cell and Organelle Size-Dependent Ribosome Biogenesis
CAMP, AMY HITCHCOCK	LEHIGH UNIVERSITY	A Feeding Tube Model for Bacterial Cell-Cell Communication
CARETTE, JAN EDUARD	STANFORD UNIVERSITY	Genetic Approaches to Discover Host Factors Critical to Dengue Virus Infection
CHEN, SHUIBING	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Studying the Progression and Regression of Beta Cell Dysfunction in Type 2 Diabetes Mellitus Using Humanized Mouse Models
CHI, PING	SLOAN-KETTERING INSTITUTE FOR CANCER RES	An Integrative Approach to Target Lineage-Specific Oncogenic Transcription Factor
CHURCHLAND, MARK	COLUMBIA UNIVERSITY HEALTH SCIENCES	A Dynamical Systems Approach to Fundamental Questions in Neuroscience
CUI, BIANXIAO	STANFORD UNIVERSITY	Engineering External Forces for Manipulating Cargo Transport in Live Neurons
DANTAS, GAUTAM	WASHINGTON UNIVERSITY	Metagenomic Engineering of Probiotic Bacteria to Improve Intestinal Colonization
DONG, P. DUC SI	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	Unlocking Regenerative Potential Through In Vivo Genetic Reprogramming
FALK, EMILY	UNIVERSITY OF PENNSYLVANIA	Can Neuroscience Dramatically Improve Our Ability to Design Health Communications
FEINBERG, ADAM WALTER	CARNEGIE-MELLON UNIVERSITY	Human Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds
GILL, HARVINDER SINGH	TEXAS TECH UNIVERSITY	Pollen Grains as Trojan Horses for Oral Vaccination
GOODMAN, ANDREW L	YALE UNIVERSITY	Defining the Contribution of Interpersonal Microbial Variation to Drug Metabolism
GORE, JEFF	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Early Warning Indicators of Tipping Points in Biological Systems
HAN, XUE	BOSTON UNIVERSITY	Light-Actuatable NanoRobots for Molecular Uncaging
HELLER, DANIEL ALAN	MEMORIAL SLOAN KETTERING CANCER CENTER	Transient Metabolite Detection for Single-Cell Metabolomics and Diagnostics
HIGGINS, JOHN MATTHEW	MASSACHUSETTS GENERAL HOSPITAL	Systems Biology of In Vivo Human Blood Cell Populations
JOHNSON, LAURA A	UNIVERSITY OF PENNSYLVANIA	Gene-Engineered Adoptive T Cell Immunotherapy of GBM
KOHLI, RAHUL MANU	UNIVERSITY OF PENNSYLVANIA	Combating Bacterial Drug Resistance by Targeting the Enzymes of Evolution
KRONAUER, DANIEL	ROCKEFELLER UNIVERSITY	Studying the Molecular Mechanisms of Social Life Using a Novel Ant Model System
LILLEMEIER, BJOERN F.	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Decipher Membrane Patterns In Situ with Super-Resolution and Dynamic Microscopy
LIU, ALLEN PO-CHIH	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Building Artificial Platelets
LIU, WENDY	UNIVERSITY OF CALIFORNIA IRVINE	Engineering Biomaterials to Exert Molecular Control of Immune Cell Function
MAIMON, GABY	ROCKEFELLER UNIVERSITY	Linking Genes to Higher Brain Function by Way of Cellular Electrophysiology
MARRAFFINI, LUCIANO A	ROCKEFELLER UNIVERSITY	Using CRISPR Immunity to Prevent the Spread of Virulence Traits Among Pathogens
MIN, WEI	COLUMBIA UNIV NEW YORK MORNINGSIDE	Label-Free Chemical Imaging for Biological Applications
MYONG, SUA	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Quantitative Stepwise Analysis of RNA Interference
NIELL, CRISTOPHER	UNIVERSITY OF OREGON	Connecting Developmental Mechanisms to Visual Function and Perception
NIMMERJAHN, AXEL	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Novel Approaches to Study Microglia Physiology and Pathology in the Intact Brain
PERMAR, SALLIE R.	DUKE UNIVERSITY	Maternal Immune Protection Against Congenital CMV Infection
PERTSINIDIS, ALEXANDROS	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Understanding Gene Transcription from First-Principles: A Single-Molecule Study
PRLIC, MARTIN	FRED HUTCHINSON CANCER RESEARCH CENTER	Paving the Way for a Novel Therapeutic Approach to Combat HIV
RODAL, AVITAL ADAH	BRANDEIS UNIVERSITY	Activity-Dependent Regulation of Membrane Traffic and Growth Signaling in Neurons
ROHATGI, RAJAT	STANFORD UNIVERSITY	Reconstructing Primary Cilia
SCHAEFER, ANNE	MOUNT SINAI SCHOOL OF MEDICINE	Cognate Microglia-Neuron Interaction and Its Role in Inflammation
SHU, XIAOKUN	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	New Principle-Based Technologies for Identifying Transient Protein Interactions
SOHAL, VIKAAS SINGH	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Reverse Engineering the Prefrontal Microcircuit
STOLTZ, DAVID A	UNIVERSITY OF IOWA	Airway Goblet Cells: Friend or Foe?
SU, MING	NORTHEASTERN UNIVERSITY	Enhanced Radiation Therapy with Nanoscale Frequency Modulators
URBAN, ALEXANDER ECKEHART	STANFORD UNIVERSITY	Genomic and Epigenomic Effects of Large CNV in Neurons from iPSC
WITTEN, ILANA	PRINCETON UNIVERSITY	Therapeutic Plasticity: A Novel Paradigm for Treating Addiction
WOODROW, KIM A.	UNIVERSITY OF WASHINGTON	Nanomaterials for Engineering Protection in the Genital Mucosa
YOO, ANDREW	WASHINGTON UNIVERSITY	MicroRNA and Neural Factor-Mediated Direct Reprogramming of Cell Fates
ZHENG, SIYANG	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	Integration of Flexible Micro Spring Array and High Throughput Microfluidics for Obtaining Clinical Relevant Information from Circulating Tumor Cells
ZOVEIN, ANN CAPELA	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Engineering Human Endothelium for Hematopoietic Stem Cell Production

2011 NIH Director's New Innovator Award (DP2)

RFA-RM-10-009

PI Name	Institution Name	Title
ALLER, STEPHEN G	UNIVERSITY OF ALABAMA AT BIRMINGHAM	Streamlined Structures of Human Integral Membrane Proteins at Atomic Resolution
BAKER, AARON BLAIR	UNIVERSITY OF TEXAS AUSTIN	Engineering Effective Revascularization Strategies for Ischemia in Disease States
BARNA, MARIA	STANFORD UNIVERSITY	Specialized Ribosomes in Control of Gene Expression and Embryonic Development
BASU, UTTIYA	COLUMBIA UNIVERSITY HEALTH SCIENCES	Non-Coding RNA Engineers Antibody Diversity
BUCHLER, NICOLAS EMILE	DUKE UNIVERSITY	Rewiring the Yeast Brain: Redundancy and Interference in Genetic Networks
CAI, LONG	CALIFORNIA INSTITUTE OF TECHNOLOGY	Systems Biology in Single Cells by Super-Resolution Barcoding
CANMAN, JULIE C	COLUMBIA UNIVERSITY HEALTH SCIENCES	IR-LAMP: Optigenetic Technology to Spatially Manipulate Protein Function In Vivo
CARLSON, ERIN ELIZABETH	UNIVERSITY OF MINNESOTA	Targeted Natural Product Diversification to Identify Novel Antibacterial Agents
CHANG, EDWARD	UNIVERSITY OF CALIFORNIA SAN DIEGO	Functional Architecture of Human Speech Motor Cortex
CHANG, JOHN T	UNIVERSITY OF CALIFORNIA SAN DIEGO	Understanding the Basis for Cellular Diversity During Adaptive Immunity
CHANG, MICHELLE C	UNIVERSITY OF CALIFORNIA BERKELEY	Discovery and Mechanistic Study of Fluorine Biochemistry
CHENG, WEI	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Single Cell with One Particle Entry (SCOPE) for Study of HIV Infection
CHRISTOFK, HEATHER RENEE	UNIVERSITY OF CALIFORNIA LOS ANGELES	Regulation of the Warburg Effect in Cancer
FRASER, HUNTER B	STANFORD UNIVERSITY	Systematic Functional Annotation of Human Cis-Regulatory Genetic Variation
GERSBACH, CHARLES A	DUKE UNIVERSITY	Engineering Morphogenetic Factors for Enhanced Genetic Reprogramming
GEURTS, ARON M	MEDICAL COLLEGE OF WISCONSIN	Advanced Genetic Engineering Technology Development
GIANNESCHI, NATHAN CLAUDE	UNIVERSITY OF CALIFORNIA SAN DIEGO	Programming Pharmacokinetics In Vivo via In Situ Switching of Nanoscale Particle Morphology
GOENTORO, LEA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Relative Perception in Wnt Signaling
HAMMOND, MING CHEN	UNIVERSITY OF CALIFORNIA BERKELEY	A Chemical Biology Approach to Tagging RNAs in Live Cells
HAN, SONGI	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Probing Early Protein Aggregation Mechanisms and Their Relationship to Disease Effects Through the Innovation of Highly Amplified and Time-Resolved Electron-Nuclear Spin Magnetic Resonance
HUANG, BO	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Solving Macromolecular Complex Architecture In Situ by Super-Resolution Microscopy
HUG, CHRISTOPHER	CHILDREN'S HOSPITAL BOSTON	Macrophage Integrated and Targeted Yeast Therapeutics
JIANG, HONGRUI	UNIVERSITY OF WISCONSIN MADISON	Accommodative Contact Lens for Presbyopic Correction
KALANTRY, SUNDEEP	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Initiation of Epigenetic Transcriptional Regulation
KASKO, ANDREA MARIE	UNIVERSITY OF CALIFORNIA LOS ANGELES	Phototunable Biomaterials to Engineer Complex 3D Cell Microenvironments
KING, MEGAN C	YALE UNIVERSITY	The Role of Nuclear Architecture in Adaptation
KOSAK, STEVEN TODD	NORTHWESTERN UNIVERSITY	Self-Organization of the Human Genome
LAMICHHANE, GYANU	JOHNS HOPKINS UNIVERSITY	New Drug for Treatment of Chronic Bacterial Infection
LEE, SEOK-YONG	DUKE UNIVERSITY	Pharmacology and Biophysics of the Voltage-Gated Sodium Channel Nav1.7: A Therapeutic Target for Pain
LEE, SHAUN W	UNIVERSITY OF NOTRE DAME	Design and Use of Novel Bacteriocins
LIEBERMAN AIDEN, EREZ	BROAD INSTITUTE, INC.	Exploring How the Genome Folds Through Proximity Ligation and Sequencing
LU, TIMOTHY	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-Throughput Nanoscale Approaches to Studying and Inhibiting Amyloid Toxicity
MAVERAKIS, EMANUAL M	UNIVERSITY OF CALIFORNIA DAVIS	Investigation and Development of New Therapeutic Avenues for Scleroderma
MITCHELL, DOUGLAS ALAN	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	A Common Denominator of Pathogenesis; A Rare Opportunity for Novel Therapeutic Development
OTT, HARALD C	MASSACHUSETTS GENERAL HOSPITAL	Organ Engineering Based on Perfusion Decellularized Matrix
PADERA, TIMOTHY P.	MASSACHUSETTS GENERAL HOSPITAL	Characterizing Lymphatic Micrometastases: Prognostic and Therapeutic Implications
PAEGEL, BRIAN M	SCRIPPS FLORIDA	Evolving and Engineering New Protease Tools for Mass Spectrometry Proteomics
PETRASCHECK, MICHAEL	SCRIPPS RESEARCH INSTITUTE	Modulation of Sensory Perception to Treat Age Related Disease
QUEITSCH, CHRISTINE	UNIVERSITY OF WASHINGTON	Does Organismal Robustness Explain the Missing Heritability in Complex Diseases?
RAJ, ARJUN	UNIVERSITY OF PENNSYLVANIA	Comprehensive Spatial Picture of Transcription in the Nucleus
SCHLIEKER, CHRISTIAN DIRK	YALE UNIVERSITY	Deciphering Novel Protein Quality Control Pathways in the Nuclear Periphery
TOBIN, DAVID M	DUKE UNIVERSITY	Modulating Eicosanoids to Treat Tuberculosis: Personalized, Host-Directed Therapy
WANG, CHIHHUNG JASON	BOSTON MEDICAL CENTER	Healthy Ideas Exchange
WEIBEL, DOUGLAS BENJAMIN	UNIVERSITY OF WISCONSIN MADISON	Revisiting the Bacterial Cell Wall as a Target for New Antibiotics
WINGERT, REBECCA ANN	UNIVERSITY OF NOTRE DAME	Identification of Kidney Regeneration Mechanisms Using the Zebrafish
WU, JOY Y	MASSACHUSETTS GENERAL HOSPITAL	In Vivo Reconstitution of the Hematopoietic Niche
XAVIER, JOAO	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Engineering Microbial Social Interactions: Towards New Anti-Biofilm Therapies
ZHANG, QI	VANDERBILT UNIVERSITY	Explore Fundamental Aspects of Neurotransmission with Multifunctional Nanosensor
ZHONG, HAINING	OREGON HEALTH AND SCIENCE UNIVERSITY	Examining the Architecture of Synapses in Brain Tissue at Nanometer Resolution

2010 NIH Director's New Innovator Award (DP2)

RFA-RM-09-011

PI Name	Institution Name	Title
AGAR, NATHALIE YR	BRIGHAM AND WOMEN'S HOSPITAL	Real-Time Stereotactic Mass Spectrometry Tissue Analysis for Intraoperative Neuro
AGARWAL, RITESH	UNIVERSITY OF PENNSYLVANIA	Optoelectronic Nanowire Probes for Investigation of Intra-Cellular Processes
AMARO, ROMMIE E	UNIVERSITY OF CALIFORNIA-IRVINE	A Structural Systems Biology Approach to Drug Discovery
ARAVIN, ALEXEI A	CALIFORNIA INSTITUTE OF TECHNOLOGY	Taming of Small RNA-based Epigenetic Mechanisms
ARMANI, ANDREA MARTIN	UNIVERSITY OF SOUTHERN CALIFORNIA	Ultrasensitive Nanolasers for Epigenetics Investigations
BAUTISTA, DIANA MICHELE	UNIVERSITY OF CALIFORNIA BERKELEY	New Approaches to Identify Molecular Mechanisms of Touch and Pain in Mammals
CEGELSKI, LYNETTE S	STANFORD UNIVERSITY	Structure, Function, and Disruption of Microbial Amyloid Assembly and Biofilm Formation
CHENG, JIANJUN	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates
CHI, NEIL C	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Directed Cardiac Cellular Programming: A New Paradigm for Cardiac Regeneration
COHEN, ADAM EZRA	HARVARD UNIVERSITY	Optical Sensing of Voltage, pH, and Small Molecules Using Microbial Rhodopsins
DAI, CHENGKAI	JACKSON LABORATORY	Role of a Novel Stress Response Mechanism-Genetic Buffering-in Tumor Evolution
DATTA, SANDEEP R	HARVARD MEDICAL SCHOOL	Revealing Fear: New Methods to Study Neural Circuits, Behavior and Disease
DI CARLO, DINO	UNIVERSITY OF CALIFORNIA LOS ANGELES	Engineering the Intracellular Micro- and Nanoenvironment
DUNN, ALEXANDER R	STANFORD UNIVERSITY	Uncovering New Roles for Mechanical Force in Tissue Development and Remodeling
EVANS, CONOR LEE	MASSACHUSETTS GENERAL HOSPITAL	Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer
FELDMAN, BRIAN J	STANFORD UNIVERSITY	Using Components of the Circadian Clock to Regulate Stem Cell Fate Decisions
FELIPPE, MARIA JULIA BEVILAQUA	CORNELL UNIVERSITY	Epigenetics: A Novel Approach in Primary Immunodeficiencies
FISCHBACH, MICHAEL ANDREW	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Identifying and Characterizing Small Molecules from the Human Microbiome
GARCIA, BENJAMIN A	PRINCETON UNIVERSITY	Novel Methodology for Quantitative High-Throughput Cancer Epigenetics
GUERRERO, THOMAS M	UNIVERSITY OF TX MD ANDERSON CAN CTR	Spatially Accurate Deformable Image Registration for Thoracic CT Application
GUZMAN, MONICA L	WEILL MEDICAL COLL OF CORNELL UNIV	Selection of Novel Therapies to Ablate Chemoresistant Myeloid Leukemia Stem Cell
HERR, AMY ELIZABETH	UNIVERSITY OF CALIFORNIA BERKELEY	Towards High Throughput Proteomics: A Micro/nanofluidic Framework for Blotless Western Technology
HOTOPP, JULIE	UNIVERSITY OF MARYLAND BALTIMORE	Impact of Bacterial-Animal Lateral Gene Transfer on Human Health
HUANG, TONY JUN	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	On-Chip Optofluidic Laser Scanning Confocal Microscope for Early Cancer Detection
HUANG, YU	UNIVERSITY OF CALIFORNIA LOS ANGELES	Graphene Nanostructures as a New Platform for Ultrasensitive Multiplexed Biologic
KHINE, MICHELLE	UNIVERSITY OF CALIFORNIA-IRVINE	Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
KLEIN, OPHIR D	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	An Evolutionary-Developmental Approach to Stem Cells Using Teeth as a Model
KRITZER, JOSHUA A	TUFTS UNIVERSITY MEDFORD	Drugging the Undruggable: Targeting Transcription Factors with Small Cyclic Pept
LAIRD, DIANA J	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Cell Competition in the Developing Mouse Germline
LAVIK, ERIN	CASE WESTERN RESERVE UNIVERSITY	Clinically Translatable Nanotechnology: Hemostasis and Neuroprotection
LEE, JIN HYUNG	UNIVERSITY OF CALIFORNIA LOS ANGELES	In Vivo Control and Functional Visualization of Stem Cell-Driven CNS Regeneration
LEVY, HARA	MEDICAL COLLEGE OF WISCONSIN	Integration of Genomics with Genetics - Molecular Phenotypes for CF Lung Disease
LEY, RUTH EMILY	CORNELL UNIVERSITY	Development of Immunization Strategies to Reshape Pathogenic Microbiomes
LUO, MINKUI	SLOAN-KETTERING INST CAN RESEARCH	Enzyme-Engineering Approaches to Dissect Protein Methylation Profiles
MAJOR, MICHAEL BENJAMIN	UNIV OF NORTH CAROLINA CHAPEL HILL	Exploitation of Near-Haploid Human Cells for Functional Gene Discovery
MARCH, JOHN C	CORNELL UNIVERSITY	Engineering Commensal Bacteria as Therapeutic Signal Mediators
NELSON, TIMOTHY JAMES	MAYO CLINIC ROCHESTER	Dysfunctional Regeneration in Cardiomyopathy: iPS-Based Diagnosis and Therapy
NICULESCU, ALEXANDER B	INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS	Developing Blood Tests for Mood Disorders
NILES, JACQUIN C	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Engineered Regulated RNA Localization and Transport in Biological Systems
NOLAN, ELIZABETH M	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Antibacterial Peptides and Zinc in Innate Immunity and Mammalian Physiology
PLATT, MANU O	GEORGIA INSTITUTE OF TECHNOLOGY	Multiscale, Mechanistic, and Predictive Models of Stroke in Sickle Cell Disease
SEALE, PATRICK	UNIVERSITY OF PENNSYLVANIA	Molecular Regulation of Brown Adipose Cell Fate in Somitic Stem Cells
SITHARAMAN, BALAJI	STATE UNIVERSITY NEW YORK STONY BROOK	Nanotechnology-Based Theranostic Technology for Bone Tissue Engineering
THEOGARAJAN, LUKE SATISH KUMAR	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Bio-Ionic Neural Interfaces
TUCKER, BUDD A	UNIVERSITY OF IOWA	Development of a Cell Replacement Therapy to Treat Retinal Degenerative Blindness
WADE, JOSEPH THOMAS	WADSWORTH CENTER	Pervasive Transcription in Bacterial Genomes
WEISS, LAUREN ANNE	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Dissecting Epistasis and Pleiotropy in Autism Towards Personalized Medicine
WONG, PAK KIN	UNIVERSITY OF ARIZONA	Mechanoregulation of Tissue Morphogenesis
YANG, CHANGHUEI	CALIFORNIA INSTITUTE OF TECHNOLOGY	Applications of Time-Reverse Tissue Turbidity Suppression to Improve Biophotonics
YIN, PENG	HARVARD MEDICAL SCHOOL	Engineering Bioimaging Probes Based on Triggered Molecular Geometry
ZHAO, XILIN	UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL	Anaerobic Shock as a Novel Treatment for Tuberculosis
ZHONG, SHENG	UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN	Evolutionary Models for Gene Regulatory Networks

2009 NIH Director's New Innovator Award (DP2)

RFA-RM-09-003

PI Name	Institution Name	Title
ALBERS, MARK W	MASSACHUSETTS GENERAL HOSPITAL	The Olfactory Neural Circuit as a Systems Level Model of Neurodegenerative Disease
ALMUTAIRI, ADAH	UNIVERSITY OF CALIFORNIA SAN DIEGO	Chemically Amplified Response Strategies for Medical Sciences; Concepts Borrowed from the Electronics Industry
ASHLEY, EUAN A	STANFORD UNIVERSITY	Nanoscale Approaches to Allelic Silencing in Myocardial Disease States
BAGNAT, MICHEL	DUKE UNIVERSITY	Discovering New Regulators of CFTR and Fluid Secretion in Zebrafish
BALAZSI, GABOR	UNIVERSITY OF TEXAS MD ANDERSON CAN CTR	Connecting the Selection of Noisy Gene Expression Deviants to Genetic Evolution
BANERJEE, IPSITA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Defining Mechanisms Controlling Stem Cell Fate during Differentiation
BROWN, EDWARD BERNARD	UNIVERSITY OF ROCHESTER	Exploiting Collagen Organization to Predict and Prevent Tumor Metastasis
CAMARGO, FERNANDO	CHILDREN'S HOSPITAL BOSTON	Analysis of Stem Cell Dynamics and Differentiation by Cellular Barcoding
CHRONIS, NIKOLAOS	UNIVERSITY OF MICHIGAN AT ANN ARBOR	A Biochip for Point-of-Care HIV/AIDS Diagnosis in the Developing World
COHEN THEODORE H	BRIGHAM AND WOMEN'S HOSPITAL	Prevalence, Risk Factors and Consequences of Complex M. tuberculosis Infections
DERIEMER, KATHRYN	UNIVERSITY OF CALIFORNIA DAVIS	Transmission and Virulence of Mycobacterium tuberculosis
DIAZ, ELVA D	UNIVERSITY OF CALIFORNIA DAVIS	Generation of Tumor Stem Cell Lines for Directed Therapeutics of Brain Cancer
ENGLER, ADAM JEFFREY	UNIVERSITY OF CALIFORNIA SAN DIEGO	"Smart" Materials to Engineer a More Complete Stem Cell Niche
GRISHOK, ALLA	COLUMBIA UNIVERSITY HEALTH SCIENCES	Investigating the Potential of Endogenous RNAi in Mediating Adaptation to Environment
HALL, IRA M	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Extent, Origin, and Control of Structural Variation in Mammalian Genomes
HEILSHORN, SARAH C	STANFORD UNIVERSITY	Engineering 3D In Vitro Niches to Reveal Fundamentals of Cellular Biomechanics
HUANG KERWYN CASEY	STANFORD UNIVERSITY	Engineering of Cell Shape and Intracellular Organization
JAIN, SANJAY	JOHNS HOPKINS UNIVERSITY	Novel Imaging Biomarkers to Address Fundamental Controversies in TB Pathogenesis
JANES, KEVIN A.	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 Oncoprotein
KEMP, MELISSA LAMBETH	GEORGIA INSTITUTE OF TECHNOLOGY	Redox Regulation of Cellular Information Processing
KREIMAN, GABRIEL	CHILDREN'S HOSPITAL BOSTON	Towards the Neuronal Correlates of Visual Awareness
KRISTICH, CHRISTOPHER J	MEDICAL COLLEGE OF WISCONSIN	Genetic Approaches to Protein-Protein Interactions Mediating Antibiotic Resistance
KURDISTANI, SIAVASH	UNIVERSITY OF CALIFORNIA LOS ANGELES	A Blueprint for Oncogenic Epigenetic Reprogramming
KWATE, NAA OYO A	COLUMBIA UNIVERSITY HEALTH SCIENCES	Immunologic Effects and a Structural "Countermarketing" Intervention: Racism, the HPA Axis, and African American Health
LEE, KIBUM	RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK	Combinatorial Approaches for Studying Multiple Cues Regulating Human Pluripotent Stem Cell (hPSC) Fate
LIM, DANIEL A	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Chromatin-Based Cellular Memory in Neural Stem Cells
LOMVARDAS, STAVROS	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Characterization of the Role of CpA Methylation in Neuronal Plasticity
MACHADO, ANDRE GUELMAN	CLEVELAND CLINIC LERNER COL/MED-CWRU	Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Modulation of the Affective Sphere of Chronic Neuropathic Pain
MASOPUST, DAVID	UNIVERSITY OF MINNESOTA TWIN CITIES	Maximizing CD8 T Cells for Protection
MORA, JORGE RODRIGO	MASSACHUSETTS GENERAL HOSPITAL	Reassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication
MUOTRI, ALYSSON R	UNIVERSITY OF CALIFORNIA SAN DIEGO	Modeling Autism with Human Pluripotent Cells
NAGRATH, SUNITHA	MASSACHUSETTS GENERAL HOSPITAL	Engineering Sensitive Microfluidic Multiplex Technology for Isolating Circulating
NANDA, VIKAS	UNIV OF MED/DENT NJ-R W JOHNSON MED SCH	Computational Design of a Synthetic Extracellular Matrix
ORDWAY, DIANE JOYCE.	COLORADO STATE UNIVERSITY-FORT COLLINS	Immune Modulation by Highly Virulent Clinical Isolates of M.Tuberculosis
OZCAN, AYDOGAN	UNIVERSITY OF CALIFORNIA LOS ANGELES	Towards Mega-Throughput, Label-Free Genomics and Proteomics: Revolutionizing Micro-Arrays
PAYNE, CHRISTINE K	GEORGIA INSTITUTE OF TECHNOLOGY	Intracellular Delivery and Targeting of Nanoparticles
PENN, ANNA A	STANFORD UNIVERSITY	Fetal Brain Damage: A Placental Disorder
PURDON, PATRICK L	MASSACHUSETTS GENERAL HOSPITAL	A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
QIAN, SHU-BING	CORNELL UNIVERSITY ITHACA	Engineering Ubiquitin Ligases to Investigate Protein Aggregation and Neurodegeneration
QIAN, WEI-JUN	BATTELLE PACIFIC NORTHWEST LABORATORIES	A Universal Multiplex Assay System for High-Throughput Clinical Applications
REIJMERS, LEON	TUFTS UNIVERSITY BOSTON	Molecular Analysis of Functional Neural Circuits
REINEKE, THERESA M	VIRGINIA POLYTECHNIC INST AND ST UNIV	Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery
RINN, JOHN LOUIS	BETH ISRAEL DEACONESS MEDICAL CENTER	RNA and Chromatin Formation: From Discovery to Mechanism
SABETI, PARDIS CHRISTINE	HARVARD UNIVERSITY	Host and Pathogen Evolution in Lassa Fever
SAINT-GENIEZ, MAGALI	SCHEPENS EYE RESEARCH INSTITUTE	Bioengineering of Bruch's Membrane for the Treatment of Age-Related Macular Degeneration
SHOU, WENYING	FRED HUTCHINSON CANCER RESEARCH CENTER	Cellular Cooperation and Cheating: An Experimental and Mathematical Analysis
SONNENBURG, JUSTIN	STANFORD UNIVERSITY	Discovery of Gut Microbiota-Targeted Small Molecules: New Tools and Therapeutics
TAVAZOIE, SOHAIL F	ROCKEFELLER UNIVERSITY	The Discovery of microRNAs That Predict Chemotherapeutic Responsiveness of Cancer
TIMLIN, JERILYN	SANDIA CORP-SANDIA NATIONAL LABORATORIES	Multiplexed Measurements of Protein Dynamics and Interactions at Extreme Resolution
TSO, CHO-LEA	UNIVERSITY OF CALIFORNIA LOS ANGELES	Cellular Quiescence and Brain Tumor Stem Cells
ULLIAN, ERIK M	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	The Role of Astrocytes in Plasticity and Disease
VEZYS, VAIVA D	UNIVERSITY OF MINNESOTA TWIN CITIES	Understanding the Persistence of Immune-Mediated Chronic Diseases
WEINBERGER, LEOR S	UNIVERSITY OF CALIFORNIA SAN DIEGO	Developing Transmissible Antivirals by Exploiting Gene-Expression Circuitry
ZHANG, CHUN-LI	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Neurogenesis De Novo in the Adult Central Nervous System

2008 NIH Director's New Innovator Award (DP2)

RFA-RM-08-014

PI Name	Institution Name	Title
BRYANT, ZEV	STANFORD UNIVERSITY	Engineering Molecular Motors
BUCKANOVICH, RONALD J	THE REGENTS OF THE UNIVERSITY OF MICHIGAN	Using Embryonic Stem Cells to Re-Create a Human Tumor Microenvironment to Develop Ovarian Cancer Therapeutic and Diagnostic Tools
CARDOZO, TIMOTHY J	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Chemical Biology Design for Malaria
CHRISTMAN, KAREN L	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Engineering a Dynamic Extracellular Matrix Microenvironment
COBB, BRIAN A	CASE WESTERN RESERVE UNIVERSITY	T Cell Dependent Immune Responses to Carbohydrate Antigens
COHN, RONALD D	JOHNS HOPKINS UNIVERSITY	Maintenance of Skeletal Muscle Mass: Lessons Learned from Hibernation
DUAN, XIANGFENG	UNIVERSITY OF CALIFORNIA, LOS ANGELES	Integrated Free-Standing Nanoprobes for Neuroscience and Beyond
FIELD, SETH J	UNIVERSITY OF CALIFORNIA, SAN DIEGO	Phosphoinositides Provide Unique Insights into Cell Biology and Pathophysiology
GITAI, ZEMER	PRINCETON UNIVERSITY	Discovering Antibiotic Drugs & Targets via High-Throughput Bacterial Cell Biology
GITLER, AARON D	UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE	Using Yeast Cells to Define Mechanisms of Human Neurodegenerative Diseases
GRACIAS, DAVID H	JOHNS HOPKINS UNIVERSITY	Minimally Invasive Micro-Nanoscale Tools and Devices for Medicine
HAYNES, CHRISTY L	UNIVERSITY OF MINNESOTA	Immune System-on-a-Chip for Quantitative Analysis of Cell Interactions during Allergy Response
KESLER, SHELLI R	STANFORD UNIVERSITY SCHOOL OF MEDICINE	Assessment and Treatment of Cognitive Deficits in Breast Cancer
KIRICHOK, YURIY	UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO	Molecular Biophysics of Mitochondrial Membranes: Defining Future Therapeutic Targets
KUMAR, SANJAY	UNIVERSITY OF CALIFORNIA, BERKELEY	Cellular Mechanobiology: Biophysics and Therapeutics
KUO, CHAY T	DUKE UNIVERSITY MEDICAL CENTER	Discovering Pathways Regulating Neurogenesis and Brain Remodeling after Injury
MAHAL, LARA K	UNIVERSITY OF TEXAS AT AUSTIN	An Integrated Systems Approach to Deconstructing Glycosylation
MURPHY, COLEEN TARA	PRINCETON UNIVERSITY LEWIS-SIGLER INSTITUTE	Slowing the Ticking Clock: C. elegans Screens for Reproductive Aging Regulators
NOMA, KENICHI	WISTAR INSTITUTE	A New Methodology to Decipher Three-Dimensional Genome Structure
OHI, MELANIE DIANE	VANDERBILT UNIVERSITY MEDICAL CENTER	Multifaceted Approaches for Studying the Structure and Function of Spliceosomes
PFENNIG, KARIN S	UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL	The Origins and Maintenance of Context-Dependent Behavior
RAMALHO-SANTOS, MIGUEL	UNIVERSTITY OF CALIFORNIA, SAN FRANCISCO	Role of Pluripotency in Development of the Germline
RECK-PETERSON, SAMARA L	HARVARD MEDICAL SCHOOL	Cellular Control of Microtubule-Based Transport: Unraveling Its Molecular Mechanism
SHAPIRO, ERIK	YALE UNIVERSITY SCHOOL OF MEDICINE	Single Cell MRI of Directed Cell Migration to Stroke
SHIH, WILLIAM M	DANA-FARBER CANCER INSTITUTE	NMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes
WAGERS, AMY JO	JOSLIN DIABETES CENTER	Aging and Rejuvenation of the Hematopoietic Stem Cell Niche
WANG, JUE D	BAYLOR COLLEGE OF MEDICINE	The Molecular Interface of Replication Elongation and the Cellular Environment
WANG, LEI	SALK INSTITUTE OF BIOLOGICAL STUDIES	Genetically Encoding Novel Amino Acids to Investigate Wnt Signaling in C. elegans
WU, JOSEPH C	STANFORD UNIVERSITY SCHOOL OF MEDICINE	Inducing Pluripotency with miRNAs: New Paradigm Shif in Cell Reprogramming
WU, SEAN M	MASSACHUSETTS GENERAL HOSPITAL	Generation of Functional Organs via Developmental Chimerism
ZEITLINGER, JULIA	STOWERS INSTITUTE FOR MEDICAL RESEARCH	Investigating Developmental Potential Based on Genome-Wide Chromatin Status

2007 NIH Director's New Innovator Award (DP2)

RFA-RM-07-009

PI Name	Institution Name	Title
AAGAARD-TILLERY, KJERSTI	BAYLOR COLLEGE OF MEDICINE	Characterization of the Fetal Primate Epigenome and Metabolome under In Utero Conditions of Maternal Obesity
BAILEY, RYAN	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
BOYDEN, EDWARD	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Novel Tools and Principles for Precisely Controlling Brain Activity
CHAMPAGNE, FRANCES	COLUMBIA UNIV NEW YORK MORNINGSIDE	Epigenetic Mechanisms Mediating the Inheritance of Reproductive Behavior
DAVIES, SEAN	VANDERBILT UNIVERSITY	Transformed Probiotic Bacteria for Treatment of Chronic Diseases
FERNANDEZ-FUNEZ, PEDRO	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	Mechanisms of Prion Misfolding
FORTUNE, SARAH	HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)	Variation in M. tuberculosis in Response to Host Selection
GARRAWAY, LEVI	DANA-FARBER CANCER INSTITUTE	Defining Melanoma Therapeutic Avenues by Integrative Functional Genomics
GUMBO, TAWANDA	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Efflux Pump Inhibitors to Reduce Duration of Antituberculosis Therapy
HACOHEN, NIR	MASSACHUSETTS GENERAL HOSPITAL	Revealing Pathogen-Sensing Pathways Using RNAi Libraries
HELDWEIN, EKATERINA	TUFTS UNIVERSITY BOSTON	Structural and Mechanistic Studies of Herpesvirus Entry into Host Cells
HOCHEDLINGER, KONRAD	MASSACHUSETTS GENERAL HOSPITAL	Reprogramming of Somatic Cells by Defined Factors
JACOBSON, KRISTEN	UNIVERSITY OF CHICAGO	From Neighborhoods to Neurons and Beyond
JANKOWSKY, JOANNA	CALIFORNIA INSTITUTE OF TECHNOLOGY	Selective Neuronal Silencing to Study Cognitive Decline in Alzheimer's Disease
JASANOFF, ALAN	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Genetically-Controlled MRI Contrast Agents for Functional Brain Imaging
JOHNSON, MARK	BRIGHAM AND WOMEN'S HOSPITAL	MicroRNA Biogenesis and the Cancer Proteome
LLINAS, MANUEL	PRINCETON UNIVERSITY	Novel Antimalarial Strategies Using Metabolomic Network Discovery
PAPA, FEROZ	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	New Tools to Measure and Correct Endoplasmic Reticulum Stress in Single Living Cells
PE'ER, DANA	COLUMBIA UNIV NEW YORK MORNINGSIDE	Genetic Variation and Regulatory Networks: Mechanisms and Complexity
PLATH, KATHRIN	UNIVERSITY OF CALIFORNIA LOS ANGELES	Chromatin and Epigenetic Inheritance
RAPE, MICHAEL	UNIVERSITY OF CALIFORNIA BERKELEY	Ubiquitin-Dependent Mechanisms of Tissue-Specific Cell Cycle Control
ROSENBLATT, JODY	UNIVERSITY OF UTAH	Identification of Signals that Extrude an Apoptotic Cell from an Epithelium
SAGHATELIAN, ALAN	HARVARD UNIVERSITY	Discovery Metabolite Profiling of the Prolyl Peptidases
SHORTER, JAMES	UNIVERSITY OF PENNSYLVANIA	Amyloid Elimination by Hsp104 and Substrate-Optimized Variants
SIPKINS, DOROTHY	UNIVERSITY OF CHICAGO	Stem Cell, Tumor and Bone Marrow Microenvironment Cross-Talk In Vivo
SPIEGEL, DAVID	YALE UNIVERSITY	Small-Molecule Antibody Recruiting Therapeutics for Treating Human Disease
SZIGETHY, EVA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
TOOMRE, DEREK	YALE UNIVERSITY	Novel TIRF Microscopy for Analyzing Trafficking and Signaling at the Cell Cortex
YANG, JING	UNIVERSITY OF CALIFORNIA SAN DIEGO	Epithelial-Mesenchymal Transition in Tumor Metastasis
YANIK, MEHMET	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Development of On-Chip Ultra High-Throughput Whole-Animal Assay Technologies

Funded Research

Funded Research

RFA-RM-22-019

RFA-RM-21-016

RFA-RM-20-012

RFA-RM-19-006

RFA-RM-18-008

RFA-RM-17-006

RFA-RM-16-004

RFA-RM-13-007

RFA-RM-13-007

RFA-RM-13-007

RFA-RM-12-016

RFA-RM-11-005

RFA-RM-10-009

RFA-RM-09-011

RFA-RM-09-003

RFA-RM-08-014

RFA-RM-07-009