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NIH Director's New Innovator  (NIA)

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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Author Journal Name PubMedID Journal Abbreviation Publication Date PubMedLink
Exploring Antibiotic Resistance in Diverse Homologs of the Dihydrofolate Reductase Protein Family through Broad Mutational Scanning. Romanowicz KJ, Resnick C, Hinton SR, Plesa C bioRxiv : the preprint server for biology 39896582 bioRxiv 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/39896582
Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 30290244 J Control Release 2018 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/30290244
Delivery technologies for cancer immunotherapy. Riley RS, June CH, Langer R, Mitchell MJ Nature reviews. Drug discovery 30622344 Nat Rev Drug Discov 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30622344
Biomaterials for vaccine-based cancer immunotherapy. Zhang R, Billingsley MM, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 30312721 J Control Release 2018 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/30312721
Nanotechnology-based strategies against SARS-CoV-2 variants. Huang X, Kon E, Han X, Zhang X, Kong N, Mitchell MJ, Peer D, Tao W Nature nanotechnology 35982317 Nat Nanotechnol 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35982317
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells. Patel SK, Billingsley MM, Frazee C, Han X, Swingle KL, Qin J, Alameh MG, Wang K, Weissman D, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 35569584 J Control Release 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35569584
Nanomaterial Interactions with Human Neutrophils. Bisso PW, Gaglione S, Guimarães PPG, Mitchell MJ, Langer R ACS biomaterials science & engineering 31497639 ACS Biomater Sci Eng 2018 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/31497639
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. Guimaraes PPG, Zhang R, Spektor R, Tan M, Chung A, Billingsley MM, El-Mayta R, Riley RS, Wang L, Wilson JM, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 31678653 J Control Release 2019 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/31678653
Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy. Mukalel AJ, Riley RS, Zhang R, Mitchell MJ Cancer letters 31100411 Cancer Lett 2019 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/31100411
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Han EL, Padilla MS, Palanki R, Kim D, Mrksich K, Li JJ, Tang S, Yoon IC, Mitchell MJ Nano letters 38259198 Nano Lett 2024 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/38259198
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines. Shepherd SJ, Han X, Mukalel AJ, El-Mayta R, Thatte AS, Wu J, Padilla MS, Alameh MG, Srikumar N, Lee D, Weissman D, Issadore D, Mitchell MJ Proceedings of the National Academy of Sciences of the United States of America 37556502 Proc Natl Acad Sci U S A 2023 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/37556502
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ Advanced materials (Deerfield Beach, Fla.) 38419362 Adv Mater 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38419362
Oxidized mRNA Lipid Nanoparticles for In Situ Chimeric Antigen Receptor Monocyte Engineering. Mukalel AJ, Hamilton AG, Billingsley MM, Li J, Thatte AS, Han X, Safford HC, Padilla MS, Papp T, Parhiz H, Weissman D, Mitchell MJ Advanced functional materials 39628840 Adv Funct Mater 2024 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/39628840
Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers. Sanati M, Figueroa-Espada CG, Han EL, Mitchell MJ, Yavari SA ACS nano 39666006 ACS Nano 2024 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/39666006
Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen. Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ Journal of the American Chemical Society 39742515 J Am Chem Soc 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39742515
Emerging strategies for nanomedicine in autoimmunity. Thatte AS, Billingsley MM, Weissman D, Melamed JR, Mitchell MJ Advanced drug delivery reviews 38342243 Adv Drug Deliv Rev 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38342243
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity. Zhong W, Lu Y, Han X, Yang J, Qin Z, Zhang W, Yu Z, Wu B, Liu S, Xu W, Zheng C, Schuchter LM, Karakousis GC, Mitchell TC, Amaravadi R, Flowers AJ, Gimotty PA, Xiao M, Mills G, Herlyn M, Dong H, Mitchell MJ, Kim J, Xu X, Guo W Cell reports 37805922 Cell Rep 2023 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/37805922
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Han X, Alameh MG, Butowska K, Knox JJ, Lundgreen K, Ghattas M, Gong N, Xue L, Xu Y, Lavertu M, Bates P, Xu J, Nie G, Zhong Y, Weissman D, Mitchell MJ Nature nanotechnology 37365276 Nat Nanotechnol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37365276
Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery. Patel SK, Billingsley MM, Mukalel AJ, Thatte AS, Hamilton AG, Gong N, El-Mayta R, Safford HC, Merolle M, Mitchell MJ Theranostics 38164140 Theranostics 2024 https://www.ncbi.nlm.nih.gov/pubmed/38164140
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering. Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ Nano letters 31951421 Nano Lett 2020 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/31951421
Nanoparticle protein corona: from structure and function to therapeutic targeting. Bashiri G, Padilla MS, Swingle KL, Shepherd SJ, Mitchell MJ, Wang K Lab on a chip 36655824 Lab Chip 2023 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/36655824
An ionizable lipid toolbox for RNA delivery. Han X, Zhang H, Butowska K, Swingle KL, Alameh MG, Weissman D, Mitchell MJ Nature communications 34903741 Nat Commun 2021 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/34903741
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. Swingle KL, Billingsley MM, Bose SK, White B, Palanki R, Dave A, Patel SK, Gong N, Hamilton AG, Alameh MG, Weissman D, Peranteau WH, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 34742747 J Control Release 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34742747
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver. Zhang R , El-Mayta R , Murdoch TJ , Warzecha CC , Billingsley MM , Shepherd SJ , Gong N , Wang L , Wilson JM , Lee D , Mitchell MJ Biomaterials science 33404020 Biomater Sci 2021 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/33404020
Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta. Safford HC, Shuler CF, Geisler HC, Thatte AS, Swingle KL, Han EL, Murray AM, Hamilton AG, Yamagata HM, Mitchell MJ Nano letters 40084657 Nano Lett 2025 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/40084657
Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ Nature communications 39856035 Nat Commun 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/39856035
Peptide-functionalized nanoparticles for brain-targeted therapeutics. Tang S, Han EL, Mitchell MJ Drug delivery and translational research 40164912 Drug Deliv Transl Res 2025 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/40164912
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. Mrksich K, Padilla MS, Joseph RA, Han EL, Kim D, Palanki R, Xu J, Mitchell MJ Journal of biomedical materials research. Part A 38487970 J Biomed Mater Res A 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38487970
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ Nature communications 38424061 Nat Commun 2024 Feb 29 https://www.ncbi.nlm.nih.gov/pubmed/38424061
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Gong N, Zhong W, Alameh MG, Han X, Xue L, El-Mayta R, Zhao G, Vaughan AE, Qin Z, Xu F, Hamilton AG, Kim D, Xu J, Kim J, Teng X, Li J, Liang XJ, Weissman D, Guo W, Mitchell MJ Nature materials 39223270 Nat Mater 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39223270
Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome. Mrksich K, Padilla MS, Mitchell MJ Advanced drug delivery reviews 39293650 Adv Drug Deliv Rev 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39293650
Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation. Atsavapranee E, Haley RM, Billingsley MM, Chan A, Ruan B, Figueroa-Espada CG, Gong N, Mukalel AJ, Bryan PN, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 38729436 J Control Release 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38729436
Enhancing in situ cancer vaccines using delivery technologies. Gong N, Alameh MG, El-Mayta R, Xue L, Weissman D, Mitchell MJ Nature reviews. Drug discovery 38951662 Nat Rev Drug Discov 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38951662
Cyclodextrins in drug delivery: applications in gene and combination therapy. Haley RM, Gottardi R, Langer R, Mitchell MJ Drug delivery and translational research 32077052 Drug Deliv Transl Res 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32077052
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition. Haley RM, Chan A, Billingsley MM, Gong N, Padilla MS, Kim EH, Wang H, Yin D, Wangensteen KJ, Tsourkas A, Mitchell MJ ACS applied materials & interfaces 37115558 ACS Appl Mater Interfaces 2023 May 10 https://www.ncbi.nlm.nih.gov/pubmed/37115558
Rational Design of Nanomedicine for Placental Disorders: Birthing a New Era in Women's Reproductive Health. Geisler HC, Safford HC, Mitchell MJ Small (Weinheim an der Bergstrasse, Germany) 37191231 Small 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/37191231
Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy. Swingle KL, Hamilton AG, Mitchell MJ Placenta 39181830 Placenta 2025 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/39181830
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ Nature nanotechnology 39354147 Nat Nanotechnol 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39354147
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE Science translational medicine 38295183 Sci Transl Med 2024 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/38295183
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Zhao G, Xue L, Geisler HC, Xu J, Li X, Mitchell MJ, Vaughan AE Proceedings of the National Academy of Sciences of the United States of America 38315853 Proc Natl Acad Sci U S A 2024 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/38315853
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ ACS nano 38861479 ACS Nano 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38861479
Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery. Zhang H, Han X, Alameh MG, Shepherd SJ, Padilla MS, Xue L, Butowska K, Weissman D, Mitchell MJ Journal of biomedical materials research. Part A 35076171 J Biomed Mater Res A 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35076171
Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain. Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva RY, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA ACS nano 37432926 ACS Nano 2023 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/37432926
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH Proceedings of the National Academy of Sciences of the United States of America 39078677 Proc Natl Acad Sci U S A 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39078677
Ionizable lipid nanoparticles for in utero mRNA delivery. Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH, Mitchell MJ Science advances 33523869 Sci Adv 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33523869
Nanomaterials for T-cell cancer immunotherapy. Gong N, Sheppard NC, Billingsley MM, June CH, Mitchell MJ Nature nanotechnology 33437036 Nat Nanotechnol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33437036
Microfluidic formulation of nanoparticles for biomedical applications. Shepherd SJ, Issadore D, Mitchell MJ Biomaterials 33965797 Biomaterials 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33965797
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device. Shepherd SJ, Warzecha CC, Yadavali S, El-Mayta R, Alameh MG, Wang L, Weissman D, Wilson JM, Issadore D, Mitchell MJ Nano letters 34189917 Nano Lett 2021 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/34189917
siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy. Figueroa-Espada CG, Guimarães PPG, Riley RS, Xue L, Wang K, Mitchell MJ Cellular and molecular bioengineering 37810998 Cell Mol Bioeng 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37810998
Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease. Palanki R, Bose SK, Dave A, White BM, Berkowitz C, Luks V, Yaqoob F, Han E, Swingle KL, Menon P, Hodgson E, Biswas A, Billingsley MM, Li L, Yiping F, Carpenter M, Trokhan A, Yeo J, Johana N, Wan TY, Alameh MG, Bennett FC, Storm PB, Jain R, Chan J, Weissman D, Mitchell MJ, Peranteau WH ACS nano 37458484 ACS Nano 2023 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/37458484
A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma. Palanki R, Swingle KL, Mitchell MJ Clinical cancer research : an official journal of the American Association for Cancer Research 36190329 Clin Cancer Res 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36190329
Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing. El-Mayta R, Padilla MS, Billingsley MM, Han X, Mitchell MJ Journal of visualized experiments : JoVE 36744791 J Vis Exp 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36744791
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy. Swingle KL, Safford HC, Geisler HC, Hamilton AG, Thatte AS, Billingsley MM, Joseph RA, Mrksich K, Padilla MS, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ Journal of the American Chemical Society 36789893 J Am Chem Soc 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36789893
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Han X, Xu Y, Ricciardi A, Xu J, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Weissman D, Mitchell MJ bioRxiv : the preprint server for biology 40060499 bioRxiv 2025 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/40060499
Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets. Haley RM, Padilla MS, El-Mayta RD, Joseph RA, Weber JA, Figueroa-Espada CG, Mukalel AJ, Ricciardi AS, Palanki R, Geisler HC, Jester MT, Davidson BL, Mitchell MJ ACS nano 40183470 ACS Nano 2025 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/40183470
Chiral Supraparticles for Controllable Nanomedicine. Yeom J, Guimaraes PPG, Ahn HM, Jung BK, Hu Q, McHugh K, Mitchell MJ, Yun CO, Langer R, Jaklenec A Advanced materials (Deerfield Beach, Fla.) 31686433 Adv Mater 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31686433
Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Huang M, Yang F, Zhang D, Lin M, Duan H, El-Mayta R, Zhang L, Qin L, Shewale SV, Pei L, Mitchell MJ, Rader DJ, Fan Y, Gong Y Nature cardiovascular research 35571674 Nat Cardiovasc Res 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35571674
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. Zhang D, Atochina-Vasserman EN, Maurya DS, Huang N, Xiao Q, Ona N, Liu M, Shahnawaz H, Ni H, Kim K, Billingsley MM, Pochan DJ, Mitchell MJ, Weissman D, Percec V Journal of the American Chemical Society 34324336 J Am Chem Soc 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34324336
Delivery technologies for in utero gene therapy. Palanki R, Peranteau WH, Mitchell MJ Advanced drug delivery reviews 33181188 Adv Drug Deliv Rev 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33181188
Peptide functionalized liposomes for receptor targeted cancer therapy. Aronson MR, Medina SH, Mitchell MJ APL bioengineering 33532673 APL Bioeng 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33532673
Engineering precision nanoparticles for drug delivery. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R Nature reviews. Drug discovery 33277608 Nat Rev Drug Discov 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33277608
Cytosolic Delivery of Small Protein Scaffolds Enables Efficient Inhibition of Ras and Myc. Chan A, Wang HH, Haley RM, Song C, Gonzalez-Martinez D, Bugaj L, Mitchell MJ, Tsourkas A Molecular pharmaceutics 35225618 Mol Pharm 2022 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/35225618
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Gong N, Han X, Xue L, Billingsley MM, Huang X, El-Mayta R, Qin J, Sheppard NC, June CH, Mitchell MJ Nature biomedical engineering 38378820 Nat Biomed Eng 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38378820
Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Hamilton AG, Swingle KL, Joseph RA, Mai D, Gong N, Billingsley MM, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ Advanced healthcare materials 37602495 Adv Healthc Mater 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37602495
Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta. Safford HC, Swingle KL, Geisler HC, Hamilton AG, Thatte AS, Ghalsasi AA, Billingsley MM, Alameh MG, Weissman D, Mitchell MJ Small (Weinheim an der Bergstrasse, Germany) 37537704 Small 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/37537704
In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism. Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ Small (Weinheim an der Bergstrasse, Germany) 38072809 Small 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38072809
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ Nature 39663452 Nature 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39663452
Solution biophysics identifies lipid nanoparticle non-sphericity, polydispersity, and dependence on internal ordering for efficacious mRNA delivery. Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Joseph RA, Yamagata HM, Ricciardi AS, Mrksich K, Issadore D, Gupta K, Mitchell MJ bioRxiv : the preprint server for biology 39763759 bioRxiv 2025 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/39763759
Lipid nanoparticle-mediated RNA delivery for immune cell modulation. Kim EH, Teerdhala SV, Padilla MS, Joseph RA, Li JJ, Haley RM, Mitchell MJ European journal of immunology 39279550 Eur J Immunol 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39279550
Piperazine-Derived Bisphosphonate-Based Ionizable Lipid Nanoparticles Enhance mRNA Delivery to the Bone Microenvironment. Yoon IC, Xue L, Chen Q, Liu J, Xu J, Siddiqui Z, Kim D, Chen B, Shi Q, Laura Han E, Cherry Ruiz M, Vining KH, Mitchell MJ Angewandte Chemie (International ed. in English) 39379320 Angew Chem Int Ed Engl 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39379320
EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 38789090 J Control Release 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38789090
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Han X, Alameh MG, Gong N, Xue L, Ghattas M, Bojja G, Xu J, Zhao G, Warzecha CC, Padilla MS, El-Mayta R, Dwivedi G, Xu Y, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ Nature chemistry 38982196 Nat Chem 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38982196
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Chan A, Haley RM, Najar MA, Gonzalez-Martinez D, Bugaj LJ, Burslem GM, Mitchell MJ, Tsourkas A Nature communications 38987546 Nat Commun 2024 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/38987546
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ Lab on a chip 39037068 Lab Chip 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39037068
In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Guimarães PPG, Figueroa-Espada CG, Riley RS, Gong N, Xue L, Sewastianik T, Dennis PS, Loebel C, Chung A, Shepherd SJ, Haley RM, Hamilton AG, El-Mayta R, Wang K, Langer R, Anderson DG, Carrasco RD, Mitchell MJ Proceedings of the National Academy of Sciences of the United States of America 37310997 Proc Natl Acad Sci U S A 2023 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/37310997
Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries. Hanna AR, Shepherd SJ, Datto GA, Navarro IB, Ricciardi AS, Padilla MS, Srikumar N, Zhang S, Yamagata HM, Meng NY, Buser JR, Mitchell MJ, Issadore DA bioRxiv : the preprint server for biology 40501993 bioRxiv 2025 May 29 https://www.ncbi.nlm.nih.gov/pubmed/40501993
Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP Science translational medicine 29343625 Sci Transl Med 2018 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/29343625
Reply to Davis: Nitric oxide regulates lymphatic contractions. Kunert C, Baish JW, Liao S, Padera TP, Munn LL Proceedings of the National Academy of Sciences of the United States of America 26719425 Proc Natl Acad Sci U S A 2016 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/26719425
Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells. Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP Angiogenesis 24201897 Angiogenesis 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24201897
The lymph node microenvironment and its role in the progression of metastatic cancer. Pereira ER, Jones D, Jung K, Padera TP Seminars in cell & developmental biology 25620792 Semin Cell Dev Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25620792
Solid stress impairs lymphocyte infiltration into lymph-node metastases. Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP Nature biomedical engineering 34282290 Nat Biomed Eng 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34282290
Inducible Nitric Oxide Synthase and CD11b(+)Gr1(+) Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP Lymphatic research and biology 30358484 Lymphat Res Biol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30358484
A retrospective analysis of commonly prescribed medications and the risk of developing breast cancer related lymphedema. Meijer EF, Bouta EM, Mendonca C, Skolny MN, Salama LW, Taghian AG, Padera TP Clinical research and trials 32864167 Clin Res Trials 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/32864167
In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ Scientific reports 27377852 Sci Rep 2016 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/27377852
Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP Journal of the National Cancer Institute 26063793 J Natl Cancer Inst 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26063793
Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK Journal of the National Cancer Institute 23899555 J Natl Cancer Inst 2013 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/23899555
Lymphatic vessels in health and disease. Kesler CT, Liao S, Munn LL, Padera TP Wiley interdisciplinary reviews. Systems biology and medicine 23209022 Wiley Interdiscip Rev Syst Biol Med 2013 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/23209022
Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25977256 FASEB J 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/25977256
Mechanobiological oscillators control lymph flow. Kunert C, Baish JW, Liao S, Padera TP, Munn LL Proceedings of the National Academy of Sciences of the United States of America 26283382 Proc Natl Acad Sci U S A 2015 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/26283382
The Lymphatic System in Disease Processes and Cancer Progression. Padera TP, Meijer EF, Munn LL Annual review of biomedical engineering 26863922 Annu Rev Biomed Eng 2016 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/26863922
Method for the quantitative measurement of collecting lymphatic vessel contraction in mice. Liao S, Jones D, Cheng G, Padera TP Journal of biological methods 25512945 J Biol Methods 2014 https://www.ncbi.nlm.nih.gov/pubmed/25512945
Measuring Vascular Permeability In Vivo. Meijer EF, Baish JW, Padera TP, Fukumura D Methods in molecular biology (Clifton, N.J.) 27581015 Methods Mol Biol 2016 https://www.ncbi.nlm.nih.gov/pubmed/27581015
Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer. Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D Proceedings of the National Academy of Sciences of the United States of America 28900008 Proc Natl Acad Sci U S A 2017 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/28900008
Murine chronic lymph node window for longitudinal intravital lymph node imaging. Meijer EFJ, Jeong HS, Pereira ER, Ruggieri TA, Blatter C, Vakoc BJ, Padera TP Nature protocols 28683064 Nat Protoc 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28683064
Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK Intravital 24353926 Intravital 2012 https://www.ncbi.nlm.nih.gov/pubmed/24353926
Novel molecular pathways in Gorham disease: implications for treatment. Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH Pediatric blood & cancer 24214028 Pediatr Blood Cancer 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24214028
Lymphatic function and immune regulation in health and disease. Liao S, Padera TP Lymphatic research and biology 24024577 Lymphat Res Biol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/24024577
Synchronization and Random Triggering of Lymphatic Vessel Contractions. Baish JW, Kunert C, Padera TP, Munn LL PLoS computational biology 27935958 PLoS Comput Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27935958
Solid stress and elastic energy as measures of tumour mechanopathology. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK Nature biomedical engineering 28966873 Nat Biomed Eng 2016 https://www.ncbi.nlm.nih.gov/pubmed/28966873
Lymph node effective vascular permeability and chemotherapy uptake. Meijer EFJ, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP Microcirculation (New York, N.Y. : 1994) 28510992 Microcirculation 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28510992
Imaging the lymphatic system. Munn LL, Padera TP Microvascular research 24956510 Microvasc Res 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/24956510
Growth and Immune Evasion of Lymph Node Metastasis. Jones D, Pereira ER, Padera TP Frontiers in oncology 29527513 Front Oncol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29527513
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK Nature biomedical engineering 30948807 Nat Biomed Eng 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30948807
Fate Mapping of Cancer Cells in Metastatic Lymph Nodes Using Photoconvertible Proteins. Pereira ER, Kedrin D, Padera TP Methods in molecular biology (Clifton, N.J.) 33704727 Methods Mol Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33704727
Lymphatic function measurements influenced by contrast agent volume and body position. Bouta EM, Blatter C, Ruggieri TA, Meijer EF, Munn LL, Vakoc BJ, Padera TP JCI insight 29367467 JCI Insight 2018 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/29367467
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK Cancer cell 25026209 Cancer Cell 2014 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/25026209
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP Science (New York, N.Y.) 29567713 Science 2018 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/29567713
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D The Journal of clinical investigation 28691930 J Clin Invest 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28691930
Local failure in parameningeal rhabdomyosarcoma correlates with poor response to induction chemotherapy. Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI International journal of radiation oncology, biology, physics 25864172 Int J Radiat Oncol Biol Phys 2015 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/25864172
Significance of lymph node metastasis in cancer dissemination of head and neck cancer. Cho JK, Hyun SH, Choi N, Kim MJ, Padera TP, Choi JY, Jeong HS Translational oncology 25926078 Transl Oncol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25926078
Editorial: rapid growth in the field of lymphatic biology. Padera TP Seminars in cell & developmental biology 25868083 Semin Cell Dev Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25868083
Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography. Blatter C, Meijer EFJ, Padera TP, Vakoc BJ Journal of biophotonics 28700145 J Biophotonics 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/28700145
Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation. Kuo AH, Ancukiewicz M, Kozak KR, Yock TI, Padera TP Radiation oncology (London, England) 25573181 Radiat Oncol 2015 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/25573181
Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing. Lacroix B, Letort G, Pitayu L, Sallé J, Stefanutti M, Maton G, Ladouceur AM, Canman JC, Maddox PS, Maddox AS, Minc N, Nédélec F, Dumont J Developmental cell 29787710 Dev Cell 2018 May 21 https://www.ncbi.nlm.nih.gov/pubmed/29787710
period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Allen VW, O'Connor RM, Ulgherait M, Zhou CG, Stone EF, Hill VM, Murphy KR, Canman JC, Ja WW, Shirasu-Hiza MM Current biology : CB 26748856 Curr Biol 2016 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/26748856
Stuck in the middle: Rac, adhesion, and cytokinesis. Davies T, Canman JC The Journal of cell biology 22945931 J Cell Biol 2012 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/22945931
High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis. Davies T, Jordan SN, Chand V, Sees JA, Laband K, Carvalho AX, Shirasu-Hiza M, Kovar DR, Dumont J, Canman JC Developmental cell 25073157 Dev Cell 2014 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/25073157
Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. Davies T, Kim HX, Romano Spica N, Lesea-Pringle BJ, Dumont J, Shirasu-Hiza M, Canman JC eLife 30028292 Elife 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/30028292
Low Efficiency Upconversion Nanoparticles for High-Resolution Coalignment of Near-Infrared and Visible Light Paths on a Light Microscope. Sundaramoorthy S, Garcia Badaracco A, Hirsch SM, Park JH, Davies T, Dumont J, Shirasu-Hiza M, Kummel AC, Canman JC ACS applied materials & interfaces 28221018 ACS Appl Mater Interfaces 2017 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/28221018
A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells. O'Connor RM, Stone EF, Wayne CR, Marcinkevicius EV, Ulgherait M, Delventhal R, Pantalia MM, Hill VM, Zhou CG, McAllister S, Chen A, Ziegenfuss JS, Grueber WB, Canman JC, Shirasu-Hiza MM The Journal of cell biology 28223318 J Cell Biol 2017 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/28223318
CYK-4 regulates Rac, but not Rho, during cytokinesis. Zhuravlev Y, Hirsch SM, Jordan SN, Dumont J, Shirasu-Hiza M, Canman JC Molecular biology of the cell 28298491 Mol Biol Cell 2017 May 1 https://www.ncbi.nlm.nih.gov/pubmed/28298491
Kinetochore components are required for central spindle assembly. Maton G, Edwards F, Lacroix B, Stefanutti M, Laband K, Lieury T, Kim T, Espeut J, Canman JC, Dumont J Nature cell biology 26123112 Nat Cell Biol 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26123112
FLIRT: fast local infrared thermogenetics for subcellular control of protein function. Hirsch SM, Sundaramoorthy S, Davies T, Zhuravlev Y, Waters JC, Shirasu-Hiza M, Dumont J, Canman JC Nature methods 30377360 Nat Methods 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30377360
Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans. Davies T, Sundaramoorthy S, Jordan SN, Shirasu-Hiza M, Dumont J, Canman JC Methods in cell biology 28065312 Methods Cell Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28065312
Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per. Ulgherait M, Chen A, Oliva MK, Kim HX, Canman JC, Ja WW, Shirasu-Hiza M Cell metabolism 27916531 Cell Metab 2016 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/27916531
Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Jordan SN, Canman JC Cytoskeleton (Hoboken, N.J.) 23047851 Cytoskeleton (Hoboken) 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/23047851
period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Allen VW, O'Connor RM, Ulgherait M, Zhou CG, Stone EF, Hill VM, Murphy KR, Canman JC, Ja WW, Shirasu-Hiza MM Current biology : CB 27218838 Curr Biol 2016 May 23 https://www.ncbi.nlm.nih.gov/pubmed/27218838
Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes. Gigant E, Stefanutti M, Laband K, Gluszek-Kustusz A, Edwards F, Lacroix B, Maton G, Canman JC, Welburn JPI, Dumont J Development (Cambridge, England) 28289130 Development 2017 May 1 https://www.ncbi.nlm.nih.gov/pubmed/28289130
Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division. Jordan SN, Davies T, Zhuravlev Y, Dumont J, Shirasu-Hiza M, Canman JC The Journal of cell biology 26728855 J Cell Biol 2016 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/26728855
Kinetochore components are required for central spindle assembly. Maton G, Edwards F, Lacroix B, Stefanutti M, Laband K, Lieury T, Kim T, Espeut J, Canman JC, Dumont J Nature cell biology 25866924 Nat Cell Biol 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25866924
Ammonium chloride alters neuronal excitability and synaptic vesicle release. Lazarenko RM, DelBove CE, Strothman CE, Zhang Q Scientific reports 28698583 Sci Rep 2017 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/28698583
Effect of Competitive Surface Functionalization on Dual-Modality Fluorescence and Magnetic Resonance Imaging of Single-Walled Carbon Nanotubes. Hong T, Lazarenko RM, Colvin DC, Flores RL, Zhang Q, Xu YQ The journal of physical chemistry. C, Nanomaterials and interfaces 26644813 J Phys Chem C Nanomater Interfaces 2012 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/26644813
Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging. DelBove CE, Strothman CE, Lazarenko RM, Huang H, Sanders CR, Zhang Q Neurobiology of disease 30885793 Neurobiol Dis 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30885793
A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Gu H, Lazarenko RM, Koktysh D, Iacovitti L, Zhang Q Stem cells translational medicine 26025981 Stem Cells Transl Med 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26025981
Fluorescent Measurement of Synaptic Activity Using FM Dyes in Dissociated Hippocampal Cultured Neurons. Lazarenko RM, DelBove CE, Zhang Q Bio-protocol 29552593 Bio Protoc 2018 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/29552593
Classic Ulcerative Pyoderma Gangrenosum Is a T Cell-Mediated Disease Targeting Follicular Adnexal Structures: A Hypothesis Based on Molecular and Clinicopathologic Studies. Wang EA, Steel A, Luxardi G, Mitra A, Patel F, Cheng MY, Wilken R, Kao J, de Ga K, Sultani H, Merleev AA, Marusina AI, Brassard A, Fung MA, Konia T, Shimoda M, Maverakis E Frontiers in immunology 29379508 Front Immunol 2017 https://www.ncbi.nlm.nih.gov/pubmed/29379508
A site-specific map of the human plasma glycome and its age and gender-associated alterations. Merleev AA, Park D, Xie Y, Kailemia MJ, Xu G, Ruhaak LR, Kim K, Hong Q, Li Q, Patel F, Wan YY, Marusina AI, Adamopoulos IE, Lal NN, Mitra A, Le ST, Shimoda M, Luxardi G, Lebrilla CB, Maverakis E Scientific reports 33060657 Sci Rep 2020 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/33060657
Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab. He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, Konia T, Grando SA, Zone JJ, Maverakis E JAMA dermatology 25901938 JAMA Dermatol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25901938
Characteristic Changes in Cell Surface Glycosylation Accompany Intestinal Epithelial Cell (IEC) Differentiation: High Mannose Structures Dominate the Cell Surface Glycome of Undifferentiated Enterocytes. Park D, Brune KA, Mitra A, Marusina AI, Maverakis E, Lebrilla CB Molecular & cellular proteomics : MCP 26355101 Mol Cell Proteomics 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26355101
Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. Park DD, Xu G, Wong M, Phoomak C, Liu M, Haigh NE, Wongkham S, Yang P, Maverakis E, Lebrilla CB Chemical science 30123482 Chem Sci 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/30123482
Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A. Merleev AA, Marusina AI, Ma C, Elder JT, Tsoi LC, Raychaudhuri SP, Weidinger S, Wang EA, Adamopoulos IE, Luxardi G, Gudjonsson JE, Shimoda M, Maverakis E JCI insight 29997305 JCI Insight 2018 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/29997305
Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans. Park DD, Phoomak C, Xu G, Olney LP, Tran KA, Park SS, Haigh NE, Luxardi G, Lert-Itthiporn W, Shimoda M, Li Q, Matoba N, Fierro F, Wongkham S, Maverakis E, Lebrilla CB Proceedings of the National Academy of Sciences of the United States of America 32213588 Proc Natl Acad Sci U S A 2020 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/32213588
NKG2C, HLA-E and their association with psoriasis. Patel F, Marusina AI, Duong C, Adamopoulos IE, Maverakis E Experimental dermatology 24279916 Exp Dermatol 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24279916
International consensus criteria for the diagnosis of Raynaud's phenomenon. Maverakis E, Patel F, Kronenberg DG, Chung L, Fiorentino D, Allanore Y, Guiducci S, Hesselstrand R, Hummers LK, Duong C, Kahaleh B, Macgregor A, Matucci-Cerinic M, Wollheim FA, Mayes MD, Gershwin ME Journal of autoimmunity 24491823 J Autoimmun 2014 Feb-Mar https://www.ncbi.nlm.nih.gov/pubmed/24491823
Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion. Park D, Arabyan N, Williams CC, Song T, Mitra A, Weimer BC, Maverakis E, Lebrilla CB Molecular & cellular proteomics : MCP 27754876 Mol Cell Proteomics 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27754876
A Phase I Study of the Combination of Rituximab and Ipilimumab in Patients with Relapsed/Refractory B-Cell Lymphoma. Tuscano JM, Maverakis E, Groshen S, Tsao-Wei D, Luxardi G, Merleev AA, Beaven A, DiPersio JF, Popplewell L, Chen R, Kirschbaum M, Schroeder MA, Newman EM Clinical cancer research : an official journal of the American Association for Cancer Research 31481504 Clin Cancer Res 2019 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/31481504
Trends in National Institutes of Health Funding of Principal Investigators in Dermatology Research by Academic Degree and Sex. Cheng MY, Sukhov A, Sultani H, Kim K, Maverakis E JAMA dermatology 27191545 JAMA Dermatol 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/27191545
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review. Sukhov A, Adamopoulos IE, Maverakis E Clinical reviews in allergy & immunology 26780035 Clin Rev Allergy Immunol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/26780035
Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review. Maverakis E, Kim K, Shimoda M, Gershwin ME, Patel F, Wilken R, Raychaudhuri S, Ruhaak LR, Lebrilla CB Journal of autoimmunity 25578468 J Autoimmun 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25578468
Clonal Vγ6(+)Vδ4(+) T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection. Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, Cai SS, Limjunyawong N, Dong X, Yeaman MR, Simon SI, Shen W, Durum SK, O'Brien RL, Maverakis E, Miller LS Proceedings of the National Academy of Sciences of the United States of America 31088972 Proc Natl Acad Sci U S A 2019 May 28 https://www.ncbi.nlm.nih.gov/pubmed/31088972
Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes. Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, Watkins SM, Patel F, Billi AC, Wiedemann J, Izumiya Y, Kumar A, Uppala R, Kahlenberg JM, Liu FT, Adamopoulos IE, Wang EA, Ma C, Cheng MY, Xiong H, Kirane A, Luxardi G, Andersen B, Tsoi LC, Lebrilla CB, Gudjonsson JE, Maverakis E JCI insight 35900871 JCI Insight 2022 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/35900871
Glycan biomarkers of autoimmunity and bile acid-associated alterations of the human glycome: Primary biliary cirrhosis and primary sclerosing cholangitis-specific glycans. Maverakis E, Merleev AA, Park D, Kailemia MJ, Xu G, Ruhaak LR, Kim K, Hong Q, Li Q, Leung P, Liakos W, Wan YY, Bowlus CL, Marusina AI, Lal NN, Xie Y, Luxardi G, Lebrilla CB Clinical immunology (Orlando, Fla.) 34403816 Clin Immunol 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34403816
Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma. Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri S, Fiorentino D, Raychaudhuri SP, Maverakis E The Journal of investigative dermatology 26134944 J Invest Dermatol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26134944
ITK inhibition for the targeted treatment of CTCL. Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E Journal of dermatological science 28434812 J Dermatol Sci 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28434812
Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection. Dillen CA, Pinsker BL, Marusina AI, Merleev AA, Farber ON, Liu H, Archer NK, Lee DB, Wang Y, Ortines RV, Lee SK, Marchitto MC, Cai SS, Ashbaugh AG, May LS, Holland SM, Freeman AF, Miller LG, Yeaman MR, Simon SI, Milner JD, Maverakis E, Miller LS The Journal of clinical investigation 29400698 J Clin Invest 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29400698
Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential. Kharkar PM, Scott RA, Olney LP, LeValley PJ, Maverakis E, Kiick KL, Kloxin AM Advanced healthcare materials 29024487 Adv Healthc Mater 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29024487
γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Nguyen CT, Maverakis E, Eberl M, Adamopoulos IE Seminars in immunopathology 31506867 Semin Immunopathol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31506867
Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission. Safra N, Hitchens PL, Maverakis E, Mitra A, Korff C, Johnson E, Kol A, Bannasch MJ, Pedersen NC, Bannasch DL Veterinary immunology and immunopathology 27590423 Vet Immunol Immunopathol 2016 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/27590423
Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages. Sun Y, Reid B, Ferreira F, Luxardi G, Ma L, Lokken KL, Zhu K, Xu G, Sun Y, Ryzhuk V, Guo BP, Lebrilla CB, Maverakis E, Mogilner A, Zhao M PLoS biology 30964858 PLoS Biol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30964858
T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1. Zhang W, Ono Y, Miyamura Y, Bowlus CL, Gershwin ME, Maverakis E Journal of autoimmunity 21636249 J Autoimmun 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21636249
CD4(+) virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity. Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, Kondo K, Olney L, Luxardi G, Miyamura Y, Yilma TD, Villalobos IB, Bergstrom JW, Kronenberg DG, Soulika AM, Adamopoulos IE, Maverakis E Journal of autoimmunity 27894837 J Autoimmun 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27894837
Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma. Zhou F, Shimoda M, Olney L, Lyu Y, Tran K, Jiang G, Nakano K, Davis RR, Tepper CG, Maverakis E, Campbell M, Li Y, Dandekar S, Izumiya Y Molecular cancer therapeutics 28847988 Mol Cancer Ther 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28847988
HDL Glycoprotein Composition and Site-Specific Glycosylation Differentiates Between Clinical Groups and Affects IL-6 Secretion in Lipopolysaccharide-Stimulated Monocytes. Krishnan S, Shimoda M, Sacchi R, Kailemia MJ, Luxardi G, Kaysen GA, Parikh AN, Ngassam VN, Johansen K, Chertow GM, Grimes B, Smilowitz JT, Maverakis E, Lebrilla CB, Zivkovic AM Scientific reports 28287093 Sci Rep 2017 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/28287093
Peristomal pyoderma gangrenosum: An exceedingly rare and overdiagnosed entity? Le ST, Wang JZ, Alexanian C, Ellis S, Martinez-Alvarado YC, Johng S, Sood A, Maverakis E Journal of the American Academy of Dermatology 30772334 J Am Acad Dermatol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30772334
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Bioengineering Human Myocardium on Native Extracellular Matrix. Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC Circulation research 26503464 Circ Res 2016 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/26503464
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Creation of a Bioengineered Skin Flap Scaffold with a Perfusable Vascular Pedicle. Jank BJ, Goverman J, Guyette JP, Charest JM, Randolph M, Gaudette GR, Gershlak JR, Purschke M, Javorsky E, Nazarian RM, Leonard DA, Cetrulo CL, Austen WG, Ott HC Tissue engineering. Part A 28323545 Tissue Eng Part A 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28323545
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DCAP: a broad-spectrum antibiotic that targets the cytoplasmic membrane of bacteria. Eun YJ, Foss MH, Kiekebusch D, Pauw DA, Westler WM, Thanbichler M, Weibel DB Journal of the American Chemical Society 22741745 J Am Chem Soc 2012 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/22741745
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Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase. Hurley KA, Santos TMA, Fensterwald MR, Rajendran M, Moore JT, Balmond EI, Blahnik BJ, Faulkner KC, Foss MH, Heinrich VA, Lammers MG, Moore LC, Reynolds GD, Shearn-Nance GP, Stearns BA, Yao ZW, Shaw JT, Weibel DB MedChemComm 30034678 Medchemcomm 2017 https://www.ncbi.nlm.nih.gov/pubmed/30034678
A chemist building paths to cell biology. Weibel DB Molecular biology of the cell 24174456 Mol Biol Cell 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24174456
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Draft Genome Sequences of Two Pairs of Human Intestinal Bifidobacterium longum subsp. longum Strains, 44B and 1-6B and 35B and 2-2B, Consecutively Isolated from Two Children after a 5-Year Time Period. Shkoporov AN, Efimov BA, Khokhlova EV, Chaplin AV, Kafarskaya LI, Durkin AS, McCorrison J, Torralba M, Gillis M, Sutton G, Weibel DB, Nelson KE, Smeianov VV Genome announcements 23682142 Genome Announc 2013 May 16 https://www.ncbi.nlm.nih.gov/pubmed/23682142
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Structure-activity studies of divin: an inhibitor of bacterial cell division. Zhou M, Eun YJ, Guzei IA, Weibel DB ACS medicinal chemistry letters 24044050 ACS Med Chem Lett 2013 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/24044050
Maspin binds to cardiolipin in mitochondria and triggers apoptosis. Mahajan N, Hoover B, Rajendram M, Shi HY, Kawasaki K, Weibel DB, Zhang M FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30786218 FASEB J 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30786218
Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria. Hurley KA, Heinrich VA, Hershfield JR, Demons ST, Weibel DB ACS medicinal chemistry letters 25941556 ACS Med Chem Lett 2015 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/25941556
Decoding the Chemical Language of Motile Bacteria by Using High-Throughput Microfluidic Assays. Crooks JA, Stilwell MD, Oliver PM, Zhong Z, Weibel DB Chembiochem : a European journal of chemical biology 26285783 Chembiochem 2015 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/26285783
Bacterial Swarming Reduces Proteus mirabilis and Vibrio parahaemolyticus Cell Stiffness and Increases β-Lactam Susceptibility. Auer GK, Oliver PM, Rajendram M, Lin TY, Yao Q, Jensen GJ, Weibel DB mBio 31594808 mBio 2019 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/31594808
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Microfluidics for High School Chemistry Students. Hemling M, Crooks JA, Oliver PM, Brenner K, Gilbertson J, Lisensky GC, Weibel DB Journal of chemical education 25584013 J Chem Educ 2014 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/25584013
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Nuclease-resistant DNA via high-density packing in polymeric micellar nanoparticle coronas. Rush AM, Thompson MP, Tatro ET, Gianneschi NC ACS nano 23379679 ACS Nano 2013 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/23379679
Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity. Blum AP, Kammeyer JK, Yin J, Crystal DT, Rush AM, Gilson MK, Gianneschi NC Journal of the American Chemical Society 25314576 J Am Chem Soc 2014 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/25314576
Polymerization of Protecting-Group-Free Peptides via ROMP. Kammeyer JK, Blum AP, Adamiak L, Hahn ME, Gianneschi NC Polymer chemistry 24015154 Polym Chem 2013 https://www.ncbi.nlm.nih.gov/pubmed/24015154
Fluorogenic Enzyme-Responsive Micellar Nanoparticles. Chien MP, Thompson MP, Lin EC, Gianneschi NC Chemical science 23585924 Chem Sci 2012 https://www.ncbi.nlm.nih.gov/pubmed/23585924
Cellular Delivery of Nanoparticles Revealed with Combined Optical and Isotopic Nanoscopy. Proetto MT, Anderton CR, Hu D, Szymanski CJ, Zhu Z, Patterson JP, Kammeyer JK, Nilewski LG, Rush AM, Bell NC, Evans JE, Orr G, Howell SB, Gianneschi NC ACS nano 27022832 ACS Nano 2016 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/27022832
Stimuli-responsive nanomaterials for biomedical applications. Blum AP, Kammeyer JK, Rush AM, Callmann CE, Hahn ME, Gianneschi NC Journal of the American Chemical Society 25474531 J Am Chem Soc 2015 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/25474531
Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents. Randolph LM, LeGuyader CLM, Hahn ME, Andolina CM, Patterson JP, Mattrey RF, Millstone JE, Botta M, Scadeng M, Gianneschi NC Chemical science 30155069 Chem Sci 2016 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/30155069
Polycatechol Nanoparticle MRI Contrast Agents. Li Y, Huang Y, Wang Z, Carniato F, Xie Y, Patterson JP, Thompson MP, Andolina CM, Ditri TB, Millstone JE, Figueroa JS, Rinehart JD, Scadeng M, Botta M, Gianneschi NC Small (Weinheim an der Bergstrasse, Germany) 26681255 Small 2016 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/26681255
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Enzyme-directed assembly of a nanoparticle probe in tumor tissue. Chien MP, Thompson MP, Barback CV, Ku TH, Hall DJ, Gianneschi NC Advanced materials (Deerfield Beach, Fla.) 23712821 Adv Mater 2013 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/23712821
Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water. Proetto MT, Rush AM, Chien MP, Abellan Baeza P, Patterson JP, Thompson MP, Olson NH, Moore CE, Rheingold AL, Andolina C, Millstone J, Howell SB, Browning ND, Evans JE, Gianneschi NC Journal of the American Chemical Society 24422495 J Am Chem Soc 2014 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/24422495
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Blending block copolymer micelles in solution; Obstacles of blending. Wright DB, Patterson JP, Gianneschi NC, Chassenieux C, Colombani O, O'Reilly RK Polymer chemistry 26918033 Polym Chem 2016 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/26918033
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Biosynthetic Polymers as Functional Materials. Carlini AS, Adamiak L, Gianneschi NC Macromolecules 27375299 Macromolecules 2016 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/27375299
Enzyme-directed assembly of nanoparticles in tumors monitored by in vivo whole animal imaging and ex vivo super-resolution fluorescence imaging. Chien MP, Carlini AS, Hu D, Barback CV, Rush AM, Hall DJ, Orr G, Gianneschi NC Journal of the American Chemical Society 24308273 J Am Chem Soc 2013 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/24308273
Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles. Randolph LM, Chien MP, Gianneschi NC Chemical science 24353895 Chem Sci 2012 May 1 https://www.ncbi.nlm.nih.gov/pubmed/24353895
Labelling Polymers and Micellar Nanoparticles via Initiation, Propagation and Termination with ROMP. Thompson MP, Randolph LM, James CR, Davalos AN, Hahn ME, Gianneschi NC Polymer chemistry 24855496 Polym Chem 2014 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/24855496
A beginning of the end: new insights into the functional organization of telomeres. Wood AM, Laster K, Rice EL, Kosak ST Nucleus (Austin, Tex.) 25961132 Nucleus 2015 https://www.ncbi.nlm.nih.gov/pubmed/25961132
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Varying levels of X chromosome coalescence in female somatic cells alters the balance of X-linked dosage compensation and is implicated in female-dominant systemic lupus erythematosus. Laskowski AI, Neems DS, Laster K, Strojny-Okyere C, Rice EL, Konieczna IM, Voss JH, Mathew JM, Leventhal JR, Ramsey-Goldman R, Smith ED, Kosak ST Scientific reports 31142749 Sci Rep 2019 May 29 https://www.ncbi.nlm.nih.gov/pubmed/31142749
A Crowdsourced nucleus: understanding nuclear organization in terms of dynamically networked protein function. Wood AM, Garza-Gongora AG, Kosak ST Biochimica et biophysica acta 24412853 Biochim Biophys Acta 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24412853
Syndecan-1 in mechanosensing of nanotopological cues in engineered materials. Le V, Lee J, Chaterji S, Spencer A, Liu YL, Kim P, Yeh HC, Kim DH, Baker AB Biomaterials 29156422 Biomaterials 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29156422
Murine model of femoral artery wire injury with implantation of a perivascular drug delivery patch. Le V, Johnson CG, Lee JD, Baker AB Journal of visualized experiments : JoVE 25742368 J Vis Exp 2015 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/25742368
A novel system for studying mechanical strain waveform-dependent responses in vascular smooth muscle cells. Lee J, Wong M, Smith Q, Baker AB Lab on a chip 24096612 Lab Chip 2013 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/24096612
Overcoming disease-induced growth factor resistance in therapeutic angiogenesis using recombinant co-receptors delivered by a liposomal system. Das S, Singh G, Baker AB Biomaterials 24138828 Biomaterials 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24138828
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Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing. Das S, Baker AB Frontiers in bioengineering and biotechnology 27843895 Front Bioeng Biotechnol 2016 https://www.ncbi.nlm.nih.gov/pubmed/27843895
Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle. Jang E, Albadawi H, Watkins MT, Edelman ER, Baker AB Proceedings of the National Academy of Sciences of the United States of America 22307630 Proc Natl Acad Sci U S A 2012 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/22307630
Analysis of a high-throughput cone-and-plate apparatus for the application of defined spatiotemporal flow to cultured cells. Spruell C, Baker AB Biotechnology and bioengineering 23280552 Biotechnol Bioeng 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23280552
Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance. Baker AB, Gibson WJ, Kolachalama VB, Golomb M, Indolfi L, Spruell C, Zcharia E, Vlodavsky I, Edelman ER Journal of the American College of Cardiology 22516446 J Am Coll Cardiol 2012 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/22516446
Computational analysis of fluid flow within a device for applying biaxial strain to cultured cells. Lee J, Baker AB Journal of biomechanical engineering 25611013 J Biomech Eng 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25611013
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High Throughput Label Free Measurement of Cancer Cell Adhesion Kinetics Under Hemodynamic Flow. Spencer A, Baker AB Scientific reports 26816215 Sci Rep 2016 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/26816215
Loss of syndecan-1 induces a pro-inflammatory phenotype in endothelial cells with a dysregulated response to atheroprotective flow. Voyvodic PL, Min D, Liu R, Williams E, Chitalia V, Dunn AK, Baker AB The Journal of biological chemistry 24554698 J Biol Chem 2014 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/24554698
Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs. Koskinas KC, Chatzizisis YS, Papafaklis MI, Coskun AU, Baker AB, Jarolim P, Antoniadis A, Edelman ER, Stone PH, Feldman CL International journal of cardiology 24148915 Int J Cardiol 2013 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/24148915
The role of scaffold microarchitecture in engineering endothelial cell immunomodulation. Indolfi L, Baker AB, Edelman ER Biomaterials 22796162 Biomaterials 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22796162
Syndesome Therapeutics for Enhancing Diabetic Wound Healing. Das S, Singh G, Majid M, Sherman MB, Mukhopadhyay S, Wright CS, Martin PE, Dunn AK, Baker AB Advanced healthcare materials 27385307 Adv Healthc Mater 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27385307
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A high-throughput mechanofluidic screening platform for investigating tumor cell adhesion during metastasis. Spencer A, Spruell C, Nandi S, Wong M, Creixell M, Baker AB Lab on a chip 26584160 Lab Chip 2016 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/26584160
Optimized design of a hyperflexible sieve electrode to enhance neurovascular regeneration for a peripheral neural interface. Veith A, Li X, Modi H, Abbaspour A, Luan L, Xie C, Baker AB Biomaterials 34147716 Biomaterials 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34147716
A multichannel dampened flow system for studies on shear stress-mediated mechanotransduction. Voyvodic PL, Min D, Baker AB Lab on a chip 22836694 Lab Chip 2012 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/22836694
Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Koskinas KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH Arteriosclerosis, thrombosis, and vascular biology 23640495 Arterioscler Thromb Vasc Biol 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23640495
Syndecan-4 enhances PDGF-BB activity in diabetic wound healing. Das S, Majid M, Baker AB Acta biomaterialia 27381525 Acta Biomater 2016 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/27381525
Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes. Das S, Monteforte AJ, Singh G, Majid M, Sherman MB, Dunn AK, Baker AB Advanced healthcare materials 26891081 Adv Healthc Mater 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26891081
Overhauser Dynamic Nuclear Polarization-Enhanced NMR Relaxometry. Franck JM, Kausik R, Han S Microporous and mesoporous materials : the official journal of the International Zeolite Association 23837010 Microporous Mesoporous Mater 2013 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/23837010
Quantitative analysis of molecular transport across liposomal bilayer by J-mediated 13C Overhauser dynamic nuclear polarization. Cheng CY, Goor OJ, Han S Analytical chemistry 23072518 Anal Chem 2012 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/23072518
Dynamic nuclear polarization methods in solids and solutions to explore membrane proteins and membrane systems. Cheng CY, Han S Annual review of physical chemistry 23331309 Annu Rev Phys Chem 2013 https://www.ncbi.nlm.nih.gov/pubmed/23331309
Nonlinear scaling of surface water diffusion with bulk water viscosity of crowded solutions. Franck JM, Scott JA, Han S Journal of the American Chemical Society 23347324 J Am Chem Soc 2013 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/23347324
Specific ions modulate diffusion dynamics of hydration water on lipid membrane surfaces. Song J, Franck J, Pincus P, Kim MW, Han S Journal of the American Chemical Society 24456096 J Am Chem Soc 2014 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/24456096
Cholesterol enhances surface water diffusion of phospholipid bilayers. Cheng CY, Olijve LL, Kausik R, Han S The Journal of chemical physics 25494784 J Chem Phys 2014 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/25494784
Nanometer-scale water- and proton-diffusion heterogeneities across water channels in polymer electrolyte membranes. Song J, Han OH, Han S Angewandte Chemie (International ed. in English) 25630609 Angew Chem Int Ed Engl 2015 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/25630609
Correlating steric hydration forces with water dynamics through surface force and diffusion NMR measurements in a lipid-DMSO-H2O system. Schrader AM, Donaldson SH Jr, Song J, Cheng CY, Lee DW, Han S, Israelachvili JN Proceedings of the National Academy of Sciences of the United States of America 26261313 Proc Natl Acad Sci U S A 2015 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/26261313
DMSO induces dehydration near lipid membrane surfaces. Cheng CY, Song J, Pas J, Meijer LH, Han S Biophysical journal 26200868 Biophys J 2015 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/26200868
Tau Aggregation Propensity Engrained in Its Solution State. Eschmann NA, Do TD, LaPointe NE, Shea JE, Feinstein SC, Bowers MT, Han S The journal of physical chemistry. B 26484390 J Phys Chem B 2015 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/26484390
Intrinsic surface-drying properties of bioadhesive proteins. Akdogan Y, Wei W, Huang KY, Kageyama Y, Danner EW, Miller DR, Martinez Rodriguez NR, Waite JH, Han S Angewandte Chemie (International ed. in English) 25168789 Angew Chem Int Ed Engl 2014 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/25168789
Functional consequences of the oligomeric assembly of proteorhodopsin. Hussain S, Kinnebrew M, Schonenbach NS, Aye E, Han S Journal of molecular biology 25597999 J Mol Biol 2015 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/25597999
Probing water density and dynamics in the chaperonin GroEL cavity. Franck JM, Sokolovski M, Kessler N, Matalon E, Gordon-Grossman M, Han SI, Goldfarb D, Horovitz A Journal of the American Chemical Society 24888581 J Am Chem Soc 2014 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/24888581
Asymmetric collapse in biomimetic complex coacervates revealed by local polymer and water dynamics. Ortony JH, Hwang DS, Franck JM, Waite JH, Han S Biomacromolecules 23540713 Biomacromolecules 2013 May 13 https://www.ncbi.nlm.nih.gov/pubmed/23540713
Anomalously Rapid Hydration Water Diffusion Dynamics Near DNA Surfaces. Franck JM, Ding Y, Stone K, Qin PZ, Han S Journal of the American Chemical Society 26256693 J Am Chem Soc 2015 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/26256693
Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Cheng CY, Varkey J, Ambroso MR, Langen R, Han S Proceedings of the National Academy of Sciences of the United States of America 24082088 Proc Natl Acad Sci U S A 2013 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/24082088
Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics. Franck JM, Pavlova A, Scott JA, Han S Progress in nuclear magnetic resonance spectroscopy 24083461 Prog Nucl Magn Reson Spectrosc 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/24083461
Ion specific effects: decoupling ion-ion and ion-water interactions. Song J, Kang TH, Kim MW, Han S Physical chemistry chemical physics : PCCP 25761273 Phys Chem Chem Phys 2015 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/25761273
Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Weeks AM, Coyle SM, Jinek M, Doudna JA, Chang MC Biochemistry 20836570 Biochemistry 2010 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/20836570
Catalytic control of enzymatic fluorine specificity. Weeks AM, Chang MC Proceedings of the National Academy of Sciences of the United States of America 23150553 Proc Natl Acad Sci U S A 2012 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/23150553
Constructing de novo biosynthetic pathways for chemical synthesis inside living cells. Weeks AM, Chang MC Biochemistry 21591680 Biochemistry 2011 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/21591680
Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK. Weeks AM, Keddie NS, Wadoux RD, O'Hagan D, Chang MC Biochemistry 24635371 Biochemistry 2014 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/24635371
Synthetic biology approaches to fluorinated polyketides. Thuronyi BW, Chang MC Accounts of chemical research 25719427 Acc Chem Res 2015 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/25719427
Natural and engineered biosynthesis of fluorinated natural products. Walker MC, Chang MC Chemical Society reviews 24776946 Chem Soc Rev 2014 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/24776946
Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides. Ad O, Thuronyi BW, Chang MC Proceedings of the National Academy of Sciences of the United States of America 28096394 Proc Natl Acad Sci U S A 2017 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/28096394
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Walker MC, Thuronyi BW, Charkoudian LK, Lowry B, Khosla C, Chang MC Science (New York, N.Y.) 24009388 Science 2013 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/24009388
Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis. Walker MC, Wen M, Weeks AM, Chang MC ACS chemical biology 22769062 ACS Chem Biol 2012 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/22769062
Editorial overview: Opportunities and challenges in synthetic biology. Chang MC, Zhao H Current opinion in chemical biology 26456417 Curr Opin Chem Biol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26456417
Mechanisms of carbon nanotube aggregation and the reversion of carbon nanotube aggregates in aqueous medium. Koh B, Cheng W Langmuir : the ACS journal of surfaces and colloids 25144606 Langmuir 2014 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/25144606
The Density Code for the Development of a Vaccine? Cheng W Journal of pharmaceutical sciences 27649885 J Pharm Sci 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27649885
Optimized Infectivity of the Cell-Free Single-Cycle Human Immunodeficiency Viruses Type 1 (HIV-1) and Its Restriction by Host Cells. Kim JH, Song H, Austin JL, Cheng W PloS one 23825637 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/23825637
Using optical trap to measure the refractive index of a single animal virus in culture fluid with high precision. Pang Y, Song H, Cheng W Biomedical optics express 27231613 Biomed Opt Express 2016 May 1 https://www.ncbi.nlm.nih.gov/pubmed/27231613
Mechanisms of HCV NS3 helicase monitored by optical tweezers. Cheng W Methods in molecular biology (Clifton, N.J.) 25579590 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25579590
Quantitation and Stability of Protein Conjugation on Liposomes for Controlled Density of Surface Epitopes. Chen Z, Moon JJ, Cheng W Bioconjugate chemistry 29528624 Bioconjug Chem 2018 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/29528624
Probability of Immobilization on Host Cell Surface Regulates Viral Infectivity. DeSantis MC, Tian C, Kim JH, Austin JL, Cheng W Physical review letters 33016741 Phys Rev Lett 2020 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/33016741
Step detection in single-molecule real time trajectories embedded in correlated noise. Arunajadai SG, Cheng W PloS one 23533612 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/23533612
Microfluidic-based high-throughput optical trapping of nanoparticles. Kotnala A, Zheng Y, Fu J, Cheng W Lab on a chip 28561826 Lab Chip 2017 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/28561826
The Single-Molecule Centroid Localization Algorithm Improves the Accuracy of Fluorescence Binding Assays. Hua B, Wang Y, Park S, Han KY, Singh D, Kim JH, Cheng W, Ha T Biochemistry 29457977 Biochemistry 2018 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/29457977
Reversible aggregation of HIV-1 Gag proteins mediated by nucleic acids. Chen Z, Cheng W Biochemical and biophysical research communications 27965093 Biochem Biophys Res Commun 2017 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/27965093
Dynasore inhibition on productive infection of HIV-1 in commonly used cell lines is independent of transferrin endocytosis. Song H, DeSantis M, Tian C, Cheng W Matters 31058179 Matters (Zur) 2018 https://www.ncbi.nlm.nih.gov/pubmed/31058179
Fluorophore and dye-assisted dispersion of carbon nanotubes in aqueous solution. Koh B, Kim G, Yoon HK, Park JB, Kopelman R, Cheng W Langmuir : the ACS journal of surfaces and colloids 22812904 Langmuir 2012 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/22812904
Detection of single fluorescent proteins inside eukaryotic cells using two-photon fluorescence. Hou X, Cheng W Biomedical optics express 22312586 Biomed Opt Express 2012 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/22312586
Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry. DeSantis MC, Kim JH, Song H, Klasse PJ, Cheng W The Journal of biological chemistry 27129237 J Biol Chem 2016 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/27129237
Optical manipulation of a single human virus for study of viral-cell interactions. Hou X, DeSantis MC, Tian C, Cheng W Proceedings of SPIE--the International Society for Optical Engineering 27746582 Proc SPIE Int Soc Opt Eng 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27746582
Label-free detection and manipulation of single biological nanoparticles. DeSantis MC, Cheng W Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 26846164 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/26846164
Optical trapping of individual human immunodeficiency viruses in culture fluid reveals heterogeneity with single-molecule resolution. Pang Y, Song H, Kim JH, Hou X, Cheng W Nature nanotechnology 25038779 Nat Nanotechnol 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/25038779
Recovering degraded quasi-solid-state dye-sensitized solar cells by applying electrical pulses. Zhang X, Huang X, Jiang H Physical chemistry chemical physics : PCCP 23545782 Phys Chem Chem Phys 2013 May 14 https://www.ncbi.nlm.nih.gov/pubmed/23545782
Liquid Tunable Microlenses based on MEMS techniques. Zeng X, Jiang H Journal of physics D: Applied physics 24163480 J Phys D Appl Phys 2013 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/24163480
Tunable dielectric liquid lens on flexible substrate. Lu YS, Tu H, Xu Y, Jiang H Applied physics letters 24493877 Appl Phys Lett 2013 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/24493877
Double Sided-Design of Electrodes Driving Tunable Dielectrophoretic Miniature Lens. Almoallem Y, Jiang H Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems 29606846 J Microelectromech Syst 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29606846
Energy Storage via Polyvinylidene Fluoride Dielectric on the Counterelectrode of Dye-Sensitized Solar Cells. Huang X, Zhang X, Jiang H Journal of power sources 24327797 J Power Sources 2014 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/24327797
Design and fabrication of an electrohydrodynamically actuated microlens with areal density modulated electrodes. Ashtiani AO, Jiang H Journal of micromechanics and microengineering : structures, devices, and systems 32773966 J Micromech Microeng 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/32773966
Lateral dye-sensitized microscale solar cells via femtosecond laser patterning. Zhang X, Huang Y, Hao B, Hewei L, Huang X, Jiang H Advanced materials technologies 31341947 Adv Mater Technol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/31341947
High Performance All-Solid-State Flexible Micro-Pseudocapacitor Based on Hierarchically Nanostructured Tungsten Trioxide Composite. Huang X, Liu H, Zhang X, Jiang H ACS applied materials & interfaces 26618406 ACS Appl Mater Interfaces 2015 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/26618406
Photovoltaically Self-Charging Cells with WO(3)·H(2)O/CNTs/PVDF Composite. Huang X, Zhang X, Jiang H RSC advances 27774146 RSC Adv 2016 https://www.ncbi.nlm.nih.gov/pubmed/27774146
Actuators based on liquid crystalline elastomer materials. Jiang H, Li C, Huang X Nanoscale 23648966 Nanoscale 2013 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/23648966
Dye-sensitized solar cell with energy storage function through PVDF/ZnO nanocomposite counter electrode. Zhang X, Huang X, Li C, Jiang H Advanced materials (Deerfield Beach, Fla.) 23740719 Adv Mater 2013 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/23740719
Electrowetting-driven variable-focus microlens on flexible surfaces. Li C, Jiang H Applied physics letters 22904571 Appl Phys Lett 2012 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/22904571
Artificial eye for scotopic vision with bioinspired all-optical photosensitivity enhancer. Liu H, Huang Y, Jiang H Proceedings of the National Academy of Sciences of the United States of America 26976565 Proc Natl Acad Sci U S A 2016 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/26976565
A Liquid Optical Phase Shifter with an Embedded Electrowetting Actuator. Ashtiani AO, Jiang H Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems 29038640 J Microelectromech Syst 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/29038640
Remote Axial Tuning in Microscopy Utilizing Hydrogel-Driven Tunable Liquid Lens. Kanhere A, Lin G, Jiang H Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems 31983867 J Microelectromech Syst 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/31983867
Scattering-layer-induced energy storage function in polymer-based quasi-solid-state dye-sensitized solar cells. Zhang X, Jiang H Applied physics letters 25829547 Appl Phys Lett 2015 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/25829547
One-step femtosecond laser patterning of light-trapping structure on dye-sensitized solar cell photoelectrodes†. Zhang X, Liu H, Huang X, Jiang H Journal of materials chemistry. C 26113977 J Mater Chem C Mater 2015 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/26113977
Fabrication and Characterization of Flexible Electrowetting on Dielectrics (EWOD) Microlens. Li C, Jiang H Micromachines 25360324 Micromachines (Basel) 2014 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/25360324
Chemiluminescent Biosensors for Detection of Second Messenger Cyclic di-GMP. Dippel AB, Anderson WA, Evans RS, Deutsch S, Hammond MC ACS chemical biology 29466657 ACS Chem Biol 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/29466657
In Vitro and In Vivo Enzyme Activity Screening via RNA-Based Fluorescent Biosensors for S-Adenosyl-l-homocysteine (SAH). Su Y, Hickey SF, Keyser SG, Hammond MC Journal of the American Chemical Society 27191512 J Am Chem Soc 2016 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/27191512
RNA-based fluorescent biosensors for live cell imaging of second messengers cyclic di-GMP and cyclic AMP-GMP. Kellenberger CA, Wilson SC, Sales-Lee J, Hammond MC Journal of the American Chemical Society 23488798 J Am Chem Soc 2013 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/23488798
An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway. Bose D, Su Y, Marcus A, Raulet DH, Hammond MC Cell chemical biology 27889408 Cell Chem Biol 2016 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/27889408
Microfluidic screening of electrophoretic mobility shifts elucidates riboswitch binding function. Karns K, Vogan JM, Qin Q, Hickey SF, Wilson SC, Hammond MC, Herr AE Journal of the American Chemical Society 23343213 J Am Chem Soc 2013 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/23343213
Next-generation RNA-based fluorescent biosensors enable anaerobic detection of cyclic di-GMP. Wang XC, Wilson SC, Hammond MC Nucleic acids research 27382070 Nucleic Acids Res 2016 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/27382070
Structural basis for molecular discrimination by a 3',3'-cGAMP sensing riboswitch. Ren A, Wang XC, Kellenberger CA, Rajashankar KR, Jones RA, Hammond MC, Patel DJ Cell reports 25818298 Cell Rep 2015 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/25818298
Tight regulation of plant immune responses by combining promoter and suicide exon elements. Gonzalez TL, Liang Y, Nguyen BN, Staskawicz BJ, Loqué D, Hammond MC Nucleic acids research 26138488 Nucleic Acids Res 2015 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/26138488
A neutral pH thermal hydrolysis method for quantification of structured RNAs. Wilson SC, Cohen DT, Wang XC, Hammond MC RNA (New York, N.Y.) 24860014 RNA 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24860014
Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs. Hickey SF, Hammond MC Chemistry & biology 24560607 Chem Biol 2014 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/24560607
In Vivo Biochemistry: Single-Cell Dynamics of Cyclic Di-GMP in Escherichia coli in Response to Zinc Overload. Yeo J, Dippel AB, Wang XC, Hammond MC Biochemistry 29052983 Biochemistry 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29052983
Designing fluorescent biosensors using circular permutations of riboswitches. Truong J, Hsieh YF, Truong L, Jia G, Hammond MC Methods (San Diego, Calif.) 29458090 Methods 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/29458090
Engineering and In Vivo Applications of Riboswitches. Hallberg ZF, Su Y, Kitto RZ, Hammond MC Annual review of biochemistry 28375743 Annu Rev Biochem 2017 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/28375743
A minimalist biosensor: Quantitation of cyclic di-GMP using the conformational change of a riboswitch aptamer. Kellenberger CA, Sales-Lee J, Pan Y, Gassaway MM, Herr AE, Hammond MC RNA biology 26114964 RNA Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26114964
RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP. Kellenberger CA, Chen C, Whiteley AT, Portnoy DA, Hammond MC Journal of the American Chemical Society 25965978 J Am Chem Soc 2015 May 27 https://www.ncbi.nlm.nih.gov/pubmed/25965978
Live Flow Cytometry Analysis of c-di-GMP Levels in Single Cell Populations. Yeo J, Wang XC, Hammond MC Methods in molecular biology (Clifton, N.J.) 28889290 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28889290
Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3', 3'-cGAMP). Hallberg ZF, Wang XC, Wright TA, Nan B, Ad O, Yeo J, Hammond MC Proceedings of the National Academy of Sciences of the United States of America 26839412 Proc Natl Acad Sci U S A 2016 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/26839412
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE Cell reports 23707065 Cell Rep 2013 May 30 https://www.ncbi.nlm.nih.gov/pubmed/23707065
High-throughput electrophoretic mobility shift assays for quantitative analysis of molecular binding reactions. Pan Y, Duncombe TA, Kellenberger CA, Hammond MC, Herr AE Analytical chemistry 25233437 Anal Chem 2014 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/25233437
Live Cell Imaging Using Riboswitch-Spinach tRNA Fusions as Metabolite-Sensing Fluorescent Biosensors. Kellenberger CA, Hallberg ZF, Hammond MC Methods in molecular biology (Clifton, N.J.) 25967055 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25967055
Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. Ousterout DG, Kabadi AM, Thakore PI, Perez-Pinera P, Brown MT, Majoros WH, Reddy TE, Gersbach CA Molecular therapy : the journal of the American Society of Gene Therapy 25492562 Mol Ther 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25492562
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Thakore PI, D'Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA Nature methods 26501517 Nat Methods 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26501517
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Housden BE, Muhar M, Gemberling M, Gersbach CA, Stainier DY, Seydoux G, Mohr SE, Zuber J, Perrimon N Nature reviews. Genetics 27795562 Nat Rev Genet 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27795562
Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases. Perez-Pinera P, Ousterout DG, Brown MT, Gersbach CA Nucleic acids research 22169954 Nucleic Acids Res 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22169954
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy. Nelson CE, Wu Y, Gemberling MP, Oliver ML, Waller MA, Bohning JD, Robinson-Hamm JN, Bulaklak K, Castellanos Rivera RM, Collier JH, Asokan A, Gersbach CA Nature medicine 30778238 Nat Med 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30778238
Increasing the specificity of CRISPR systems with engineered RNA secondary structures. Kocak DD, Josephs EA, Bhandarkar V, Adkar SS, Kwon JB, Gersbach CA Nature biotechnology 30988504 Nat Biotechnol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30988504
Genome Engineering for Personalized Arthritis Therapeutics. Adkar SS, Brunger JM, Willard VP, Wu CL, Gersbach CA, Guilak F Trends in molecular medicine 28887050 Trends Mol Med 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28887050
The role of single-cell analyses in understanding cell lineage commitment. Gibson TM, Gersbach CA Biotechnology journal 23520130 Biotechnol J 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23520130
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Gaj T, Gersbach CA, Barbas CF 3rd Trends in biotechnology 23664777 Trends Biotechnol 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23664777
Editing the epigenome: technologies for programmable transcription and epigenetic modulation. Thakore PI, Black JB, Hilton IB, Gersbach CA Nature methods 26820547 Nat Methods 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26820547
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. Polstein LR, Perez-Pinera P, Kocak DD, Vockley CM, Bledsoe P, Song L, Safi A, Crawford GE, Reddy TE, Gersbach CA Genome research 26025803 Genome Res 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26025803
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. Ousterout DG, Perez-Pinera P, Thakore PI, Kabadi AM, Brown MT, Qin X, Fedrigo O, Mouly V, Tremblay JP, Gersbach CA Molecular therapy : the journal of the American Society of Gene Therapy 23732986 Mol Ther 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23732986
RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Perez-Pinera P, Kocak DD, Vockley CM, Adler AF, Kabadi AM, Polstein LR, Thakore PI, Glass KA, Ousterout DG, Leong KW, Guilak F, Crawford GE, Reddy TE, Gersbach CA Nature methods 23892895 Nat Methods 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23892895
Highly active zinc-finger nucleases by extended modular assembly. Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ Genome research 23222846 Genome Res 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23222846
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage. Josephs EA, Kocak DD, Fitzgibbon CJ, McMenemy J, Gersbach CA, Marszalek PE Nucleic acids research 26384421 Nucleic Acids Res 2015 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/26384421
Genome-editing Technologies for Gene and Cell Therapy. Maeder ML, Gersbach CA Molecular therapy : the journal of the American Society of Gene Therapy 26755333 Mol Ther 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26755333
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, Wu X, Zhu J, Boyington JC, Chen X, Shi W, Yang ZY, Doria-Rose NA, McKee K, O'Dell S, Schmidt SD, Chuang GY, Druz A, Soto C, Yang Y, Zhang B, Zhou T, Todd JP, Lloyd KE, Eudailey J, Roberts KE, Donald BR, Bailer RT, Ledgerwood J, NISC Comparative Sequencing Program, Mullikin JC, Shapiro L, Koup RA, Graham BS, Nason MC, Connors M, Haynes BF, Rao SS, Roederer M, Kwong PD, Mascola JR, Nabel GJ Journal of virology 25142607 J Virol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25142607
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LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T Molecular cell 24857549 Mol Cell 2014 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/24857549
Visualization of lncRNA by single-molecule fluorescence in situ hybridization. Dunagin M, Cabili MN, Rinn J, Raj A Methods in molecular biology (Clifton, N.J.) 25555572 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25555572
Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature. Facciponte JG, Ugel S, De Sanctis F, Li C, Wang L, Nair G, Sehgal S, Raj A, Matthaiou E, Coukos G, Facciabene A The Journal of clinical investigation 24642465 J Clin Invest 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24642465
Targeting tumor vasculature: expanding the potential of DNA cancer vaccines. Ugel S, Facciponte JG, De Sanctis F, Facciabene A Cancer immunology, immunotherapy : CII 26267042 Cancer Immunol Immunother 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26267042
Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation. Nair G, Abranches E, Guedes AM, Henrique D, Raj A Scientific reports 26292941 Sci Rep 2015 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/26292941
Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue. Shah NA, Levesque MJ, Raj A, Sarkar CA Journal of cell science 26159733 J Cell Sci 2015 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/26159733
SAVER: gene expression recovery for single-cell RNA sequencing. Huang M, Wang J, Torre E, Dueck H, Shaffer S, Bonasio R, Murray JI, Raj A, Li M, Zhang NR Nature methods 29941873 Nat Methods 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29941873
A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition. Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA Genes & development 27340175 Genes Dev 2016 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/27340175
Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Padovan-Merhar O, Nair GP, Biaesch AG, Mayer A, Scarfone S, Foley SW, Wu AR, Churchman LS, Singh A, Raj A Molecular cell 25866248 Mol Cell 2015 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/25866248
Multiplexed detection of viral infections using rapid in situ RNA analysis on a chip. Shaffer SM, Joshi RP, Chambers BS, Sterken D, Biaesch AG, Gabrieli DJ, Li Y, Feemster KA, Hensley SE, Issadore D, Raj A Lab on a chip 26113495 Lab Chip 2015 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/26113495
The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development. Walton T, Preston E, Nair G, Zacharias AL, Raj A, Murray JI PLoS genetics 25738873 PLoS Genet 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25738873
The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries. Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA Molecular cell 28388437 Mol Cell 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28388437
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL Nature structural & molecular biology 24463464 Nat Struct Mol Biol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24463464
linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Maamar H, Cabili MN, Rinn J, Raj A Genes & development 23723417 Genes Dev 2013 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/23723417
Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S Proceedings of the National Academy of Sciences of the United States of America 25197089 Proc Natl Acad Sci U S A 2014 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/25197089
Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant. Ginart P, Kalish JM, Jiang CL, Yu AC, Bartolomei MS, Raj A Genes & development 26944681 Genes Dev 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26944681
Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I. Xu J, Mercado-López X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, López CB mBio 26443454 mBio 2015 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/26443454
What's Luck Got to Do with It: Single Cells, Multiple Fates, and Biological Nondeterminism. Symmons O, Raj A Molecular cell 27259209 Mol Cell 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27259209
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J Nature 27525555 Nature 2016 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/27525555
Control of somatic tissue differentiation by the long non-coding RNA TINCR. Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, Johnston D, Kim GE, Spitale RC, Flynn RA, Zheng GX, Aiyer S, Raj A, Rinn JL, Chang HY, Khavari PA Nature 23201690 Nature 2013 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/23201690
Visualizing SNVs to quantify allele-specific expression in single cells. Levesque MJ, Ginart P, Wei Y, Raj A Nature methods 23913259 Nat Methods 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23913259
Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency. Abranches E, Guedes AM, Moravec M, Maamar H, Svoboda P, Raj A, Henrique D Development (Cambridge, England) 25005472 Development 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/25005472
Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels. Dar RD, Shaffer SM, Singh A, Razooky BS, Simpson ML, Raj A, Weinberger LS PloS one 27467384 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27467384
Using variability in gene expression as a tool for studying gene regulation. Padovan-Merhar O, Raj A Wiley interdisciplinary reviews. Systems biology and medicine 23996796 Wiley Interdiscip Rev Syst Biol Med 2013 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/23996796
Visualizing adenosine-to-inosine RNA editing in single mammalian cells. Mellis IA, Gupte R, Raj A, Rouhanifard SH Nature methods 28604724 Nat Methods 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28604724
Single-cell differences in matrix gene expression do not predict matrix deposition. Cote AJ, McLeod CM, Farrell MJ, McClanahan PD, Dunagin MC, Raj A, Mauck RL Nature communications 26936319 Nat Commun 2016 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/26936319
Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting. Symmons O, Chang M, Mellis IA, Kalish JM, Park J, Suszták K, Bartolomei MS, Raj A PLoS genetics 30625149 PLoS Genet 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30625149
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Paralkar VR, Mishra T, Luan J, Yao Y, Kossenkov AV, Anderson SM, Dunagin M, Pimkin M, Gore M, Sun D, Konuthula N, Raj A, An X, Mohandas N, Bodine DM, Hardison RC, Weiss MJ Blood 24497530 Blood 2014 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/24497530
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a. Weis B, Schmidt J, Maamar H, Raj A, Lin H, Tóth C, Riedmann K, Raddatz G, Seitz HK, Ho AD, Lyko F, Linhart HG Oncogene 24837369 Oncogene 2015 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/24837369
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH Proceedings of the National Academy of Sciences of the United States of America 29078295 Proc Natl Acad Sci U S A 2017 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/29078295
Specialized ribosomes: a new frontier in gene regulation and organismal biology. Xue S, Barna M Nature reviews. Molecular cell biology 22617470 Nat Rev Mol Cell Biol 2012 May 23 https://www.ncbi.nlm.nih.gov/pubmed/22617470
Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Kondrashov N, Pusic A, Stumpf CR, Shimizu K, Hsieh AC, Ishijima J, Shiroishi T, Barna M Cell 21529712 Cell 2011 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/21529712
Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins. Shi Z, Barna M Annual review of cell and developmental biology 26443190 Annu Rev Cell Dev Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26443190
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M Cell 28575669 Cell 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28575669
Cis-regulatory RNA elements that regulate specialized ribosome activity. Xue S, Barna M RNA biology 26327194 RNA Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26327194
RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation. Xue S, Tian S, Fujii K, Kladwang W, Das R, Barna M Nature 25409156 Nature 2015 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/25409156
Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide. Shi Z, Fujii K, Kovary KM, Genuth NR, Röst HL, Teruel MN, Barna M Molecular cell 28625553 Mol Cell 2017 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/28625553
Differential Requirements for eIF4E Dose in Normal Development and Cancer. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D Cell 26095252 Cell 2015 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/26095252
Ribosomes take control. Barna M Proceedings of the National Academy of Sciences of the United States of America 23243144 Proc Natl Acad Sci U S A 2013 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/23243144
Tailor made protein synthesis for HSCs. Barna M, Ruggero D Cell stem cell 24702992 Cell Stem Cell 2014 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/24702992
Covalent Protein Labeling by SpyTag-SpyCatcher in Fixed Cells for Super-Resolution Microscopy. Pessino V, Citron YR, Feng S, Huang B Chembiochem : a European journal of chemical biology 28514494 Chembiochem 2017 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/28514494
EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms. van Lengerich B, Agnew C, Puchner EM, Huang B, Jura N Proceedings of the National Academy of Sciences of the United States of America 28320942 Proc Natl Acad Sci U S A 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28320942
2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas. Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM Cancer research 29358170 Cancer Res 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29358170
The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles. Citron YR, Fagerstrom CJ, Keszthelyi B, Huang B, Rusan NM, Kelly MJS, Agard DA PloS one 29315319 PLoS One 2018 https://www.ncbi.nlm.nih.gov/pubmed/29315319
Correction of depth-dependent aberrations in 3D single-molecule localization and super-resolution microscopy. McGorty R, Schnitzbauer J, Zhang W, Huang B Optics letters 24562125 Opt Lett 2014 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/24562125
Little fish, big catch: zebrafish as a model for kidney disease. Poureetezadi SJ, Wingert RA Kidney international 27165832 Kidney Int 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27165832
Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling. Li Y, Cheng CN, Verdun VA, Wingert RA Developmental biology 24309209 Dev Biol 2014 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/24309209
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. Gerlach GF, Wingert RA Developmental biology 25446529 Dev Biol 2014 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/25446529
Microbead Implantation in the Zebrafish Embryo. Gerlach GF, Morales EE, Wingert RA Journal of visualized experiments : JoVE 26274386 J Vis Exp 2015 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/26274386
Cutting edge: Asymmetric memory T cell division in response to rechallenge. Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL Journal of immunology (Baltimore, Md. : 1950) 22467651 J Immunol 2012 May 1 https://www.ncbi.nlm.nih.gov/pubmed/22467651
Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, Chang JT Oncotarget 26930717 Oncotarget 2016 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/26930717
Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT Journal of immunology (Baltimore, Md. : 1950) 29703862 J Immunol 2018 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/29703862
USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis. Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT Molecular cancer research : MCR 29724812 Mol Cancer Res 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29724812
Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT Inflammatory bowel diseases 25545378 Inflamm Bowel Dis 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25545378
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang JT, Gonzalez DJ, Nizet V Nature communications 26458291 Nat Commun 2015 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/26458291
Ubiquitylation of CD98 limits cell proliferation and clonal expansion. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH Journal of cell science 26493331 J Cell Sci 2015 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/26493331
Reply to: "CD8(+) T cell diversification by asymmetric cell division". Arsenio J, Kakaradov B, Metz PJ, Yeo GW, Chang JT Nature immunology 26287585 Nat Immunol 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26287585
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT The Journal of clinical investigation 28846070 J Clin Invest 2017 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/28846070
Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. Jung HR, Song KH, Chang JT, Doh J PloS one 24632942 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24632942
Asymmetric Cell Division in T Lymphocyte Fate Diversification. Arsenio J, Metz PJ, Chang JT Trends in immunology 26474675 Trends Immunol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26474675
A gp130-Src-YAP module links inflammation to epithelial regeneration. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M Nature 25731159 Nature 2015 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/25731159
Molecular regulation of effector and memory T cell differentiation. Chang JT, Wherry EJ, Goldrath AW Nature immunology 25396352 Nat Immunol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25396352
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Metz PJ, Lopez J, Kim SH, Akimoto K, Ohno S, Chang JT Scientific reports 26765121 Sci Rep 2016 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/26765121
Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι. Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley K, Akimoto K, Ohno S, Yeo GW, Chang JT Journal of immunology (Baltimore, Md. : 1950) 25617472 J Immunol 2015 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/25617472
The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. Ngoi SM, Lopez JM, Chang JT Journal of immunology (Baltimore, Md. : 1950) 27029586 J Immunol 2016 May 15 https://www.ncbi.nlm.nih.gov/pubmed/27029586
Early transcriptional and epigenetic regulation of CD8(+) T cell differentiation revealed by single-cell RNA sequencing. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW Nature immunology 28218746 Nat Immunol 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28218746
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT Journal of immunology (Baltimore, Md. : 1950) 28515282 J Immunol 2017 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/28515282
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Arsenio J, Kakaradov B, Metz PJ, Kim SH, Yeo GW, Chang JT Nature immunology 24584088 Nat Immunol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24584088
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe SE, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang JT Journal of immunology (Baltimore, Md. : 1950) 25667416 J Immunol 2015 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/25667416
Polarity and lymphocyte fate determination. Chang JT Current opinion in cell biology 22658837 Curr Opin Cell Biol 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22658837
Update on Janus kinase antagonists in inflammatory bowel disease. Boland BS, Sandborn WJ, Chang JT Gastroenterology clinics of North America 25110261 Gastroenterol Clin North Am 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25110261
Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT Alimentary pharmacology & therapeutics 25041724 Aliment Pharmacol Ther 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25041724
A multiparametric computational algorithm for comprehensive assessment of genetic mutations in mucopolysaccharidosis type IIIA (Sanfilippo syndrome). Ugrinov KG, Freed SD, Thomas CL, Lee SW PloS one 25807448 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/25807448
The wide world of ribosomally encoded bacterial peptides. Flaherty RA, Freed SD, Lee SW PLoS pathogens 25079075 PLoS Pathog 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/25079075
CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants. Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ Journal of bacteriology 26216843 J Bacteriol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26216843
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains. Fields FR, Freed SD, Carothers KE, Hamid MN, Hammers DE, Ross JN, Kalwajtys VR, Gonzalez AJ, Hildreth AD, Friedberg I, Lee SW Drug development research 31483516 Drug Dev Res 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31483516
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors. Tokalı FS, Demir Y, Demircioğlu İH, Türkeş C, Kalay E, Şendil K, Beydemir Ş Drug development research 34585414 Drug Dev Res 2022 May https://www.ncbi.nlm.nih.gov/pubmed/34585414
Using bacterial genomes and essential genes for the development of new antibiotics. Fields FR, Lee SW, McConnell MJ Biochemical pharmacology 27940263 Biochem Pharmacol 2017 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/27940263
HIV protease inhibitors block streptolysin S production. Maxson T, Deane CD, Molloy EM, Cox CL, Markley AL, Lee SW, Mitchell DA ACS chemical biology 25668590 ACS Chem Biol 2015 May 15 https://www.ncbi.nlm.nih.gov/pubmed/25668590
Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties. Corman HN, Ross JN, Fields FR, Shoue DA, McDowell MA, Lee SW Microbiology spectrum 36342284 Microbiol Spectr 2022 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/36342284
Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells. Flaherty RA, Lee SW Journal of visualized experiments : JoVE 27585035 J Vis Exp 2016 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/27585035
Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics. Kane TL, Carothers KE, Lee SW Current drug targets 27894236 Curr Drug Targets 2018 https://www.ncbi.nlm.nih.gov/pubmed/27894236
A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins. Morton JT, Freed SD, Lee SW, Friedberg I BMC bioinformatics 26558535 BMC Bioinformatics 2015 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/26558535
Design and evaluation of a peptide-based immunotoxin for breast cancer therapeutics. Weigel KJ, Shen L, Thomas CL, Alber D, Drapalik L, Schafer ZT, Lee SW FEBS open bio 25853036 FEBS Open Bio 2015 https://www.ncbi.nlm.nih.gov/pubmed/25853036
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. Ross JN, Fields FR, Kalwajtys VR, Gonzalez AJ, O'Connor S, Zhang A, Moran TE, Hammers DE, Carothers KE, Lee SW Frontiers in microbiology 33281785 Front Microbiol 2020 https://www.ncbi.nlm.nih.gov/pubmed/33281785
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW The Journal of antibiotics 29463889 J Antibiot (Tokyo) 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29463889
Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection. Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW Frontiers in cellular and infection microbiology 30018884 Front Cell Infect Microbiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30018884
Knowing is half the battle: targeting virulence factors of group A Streptococcus for vaccine and therapeutics. Thomas CL, Lee SW Current drug targets 22206254 Curr Drug Targets 2012 Mar https://www.ncbi.nlm.nih.gov/pubmed/22206254
Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection. Flaherty RA, Puricelli JM, Higashi DL, Park CJ, Lee SW Infection and immunity 26238711 Infect Immun 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26238711
Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution. Vu HM, Hammers DE, Liang Z, Nguyen GL, Benz ME, Moran TE, Higashi DL, Park CJ, Ayinuola YA, Donahue DL, Flores-Mireles AL, Ploplis VA, Castellino FJ, Lee SW Frontiers in cardiovascular medicine 34179133 Front Cardiovasc Med 2021 https://www.ncbi.nlm.nih.gov/pubmed/34179133
In Vivo Rescue of the Hematopoietic Niche By Pluripotent Stem Cell Complementation of Defective Osteoblast Compartments. Chubb R, Oh J, Riley AK, Kimura T, Wu SM, Wu JY Stem cells (Dayton, Ohio) 28741855 Stem Cells 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28741855
Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the DATA-HRpQCT Study. Tsai JN, Uihlein AV, Burnett-Bowie SA, Neer RM, Zhu Y, Derrico N, Lee H, Bouxsein ML, Leder BZ Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 25043459 J Bone Miner Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25043459
PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization. Panaroni C, Fulzele K, Saini V, Chubb R, Pajevic PD, Wu JY Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 26191777 J Bone Miner Res 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26191777
Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts. Zhu H, Swami S, Yang P, Shapiro F, Wu JY Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 31793059 J Bone Miner Res 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/31793059
Teriparatide (PTH 1-34) treatment increases peripheral hematopoietic stem cells in postmenopausal women. Yu EW, Kumbhani R, Siwila-Sackman E, DeLelys M, Preffer FI, Leder BZ, Wu JY Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 24420643 J Bone Miner Res 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24420643
Engineering genetic circuits that compute and remember. Siuti P, Yazbek J, Lu TK Nature protocols 24810038 Nat Protoc 2014 https://www.ncbi.nlm.nih.gov/pubmed/24810038
Complete Genome Sequence of Pseudomonas aeruginosa Phage vB_PaeM_CEB_DP1. Pires DP, Sillankorva S, Kropinski AM, Lu TK, Azeredo J Genome announcements 26404589 Genome Announc 2015 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/26404589
Synthetic biology. Genomically encoded analog memory with precise in vivo DNA writing in living cell populations. Farzadfard F, Lu TK Science (New York, N.Y.) 25395541 Science 2014 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/25395541
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Citorik RJ, Mimee M, Lu TK Nature biotechnology 25240928 Nat Biotechnol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25240928
DNA nanotechnology: new adventures for an old warhorse. Zakeri B, Lu TK Current opinion in chemical biology 26056949 Curr Opin Chem Biol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26056949
Advancing bacteriophage-based microbial diagnostics with synthetic biology. Lu TK, Bowers J, Koeris MS Trends in biotechnology 23608522 Trends Biotechnol 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23608522
Foundations and Emerging Paradigms for Computing in Living Cells. Ma KC, Perli SD, Lu TK Journal of molecular biology 26908220 J Mol Biol 2016 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/26908220
Strong underwater adhesives made by self-assembling multi-protein nanofibres. Zhong C, Gurry T, Cheng AA, Downey J, Deng Z, Stultz CM, Lu TK Nature nanotechnology 25240674 Nat Nanotechnol 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25240674
Enhancing phage therapy through synthetic biology and genome engineering. Lenneman BR, Fernbach J, Loessner MJ, Lu TK, Kilcher S Current opinion in biotechnology 33310655 Curr Opin Biotechnol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33310655
Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis. Yehl K, Lemire S, Yang AC, Ando H, Mimee M, Torres MT, de la Fuente-Nunez C, Lu TK Cell 31585083 Cell 2019 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/31585083
A synthetic biology framework for programming eukaryotic transcription functions. Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, Joung JK, Collins JJ Cell 22863014 Cell 2012 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/22863014
Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. Radovic-Moreno AF, Lu TK, Puscasu VA, Yoon CJ, Langer R, Farokhzad OC ACS nano 22471841 ACS Nano 2012 May 22 https://www.ncbi.nlm.nih.gov/pubmed/22471841
Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics. Cheng AA, Ding H, Lu TK Proceedings of the National Academy of Sciences of the United States of America 25114216 Proc Natl Acad Sci U S A 2014 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/25114216
Bacteriophage-based synthetic biology for the study of infectious diseases. Citorik RJ, Mimee M, Lu TK Current opinion in microbiology 24997401 Curr Opin Microbiol 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24997401
Synthetic Biogenesis of Bacterial Amyloid Nanomaterials with Tunable Inorganic-Organic Interfaces and Electrical Conductivity. Seker UO, Chen AY, Citorik RJ, Lu TK ACS synthetic biology 27794590 ACS Synth Biol 2017 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/27794590
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. Wong AS, Choi GC, Cui CH, Pregernig G, Milani P, Adam M, Perli SD, Kazer SW, Gaillard A, Hermann M, Shalek AK, Fraenkel E, Lu TK Proceedings of the National Academy of Sciences of the United States of America 26864203 Proc Natl Acad Sci U S A 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26864203
Rule-based design of synthetic transcription factors in eukaryotes. Purcell O, Peccoud J, Lu TK ACS synthetic biology 24933274 ACS Synth Biol 2014 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/24933274
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. Farzadfard F, Perli SD, Lu TK ACS synthetic biology 23977949 ACS Synth Biol 2013 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/23977949
Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica. Cleto S, Haslinger K, Prather KLJ, Lu TK BMC biology 33722216 BMC Biol 2021 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/33722216
Multiplexed Sequence Encoding: A Framework for DNA Communication. Zakeri B, Carr PA, Lu TK PloS one 27050646 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27050646
Towards a whole-cell modeling approach for synthetic biology. Purcell O, Jain B, Karr JR, Covert MW, Lu TK Chaos (Woodbury, N.Y.) 23822510 Chaos 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23822510
Synthetic biology: an emerging engineering discipline. Cheng AA, Lu TK Annual review of biomedical engineering 22577777 Annu Rev Biomed Eng 2012 https://www.ncbi.nlm.nih.gov/pubmed/22577777
Synthetic biology of antimicrobial discovery. Zakeri B, Lu TK ACS synthetic biology 23654251 ACS Synth Biol 2013 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/23654251
Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells. Nissim L, Perli SD, Fridkin A, Perez-Pinera P, Lu TK Molecular cell 24837679 Mol Cell 2014 May 22 https://www.ncbi.nlm.nih.gov/pubmed/24837679
Massively parallel high-order combinatorial genetics in human cells. Wong AS, Choi GC, Cheng AA, Purcell O, Lu TK Nature biotechnology 26280411 Nat Biotechnol 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26280411
Gene networks that compensate for crosstalk with crosstalk. Müller IE, Rubens JR, Jun T, Graham D, Xavier R, Lu TK Nature communications 31492904 Nat Commun 2019 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/31492904
A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity. King MC, Lusk CP Current opinion in cell biology 27031045 Curr Opin Cell Biol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27031045
A role for nuclear envelope-bridging complexes in homology-directed repair. Swartz RK, Rodriguez EC, King MC Molecular biology of the cell 24943839 Mol Biol Cell 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24943839
A quality control mechanism linking meiotic success to release of ascospores. Guo H, King MC PloS one 24312672 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24312672
Forces, fluctuations, and self-organization in the nucleus. Pederson T, King MC, Marko JF Molecular biology of the cell 26543199 Mol Biol Cell 2015 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/26543199
TeloPCR-seq: a high-throughput sequencing approach for telomeres. Bennett HW, Liu N, Hu Y, King MC FEBS letters 27714790 FEBS Lett 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27714790
RNA-DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast. Hu Y, Bennett HW, Liu N, Moravec M, Williams JF, Azzalin CM, King MC Genetics 31405990 Genetics 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31405990
The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. Wälde S, King MC Journal of cell science 24963130 J Cell Sci 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24963130
Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks. Leland BA, Chen AC, Zhao AY, Wharton RC, King MC eLife 29697047 Elife 2018 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/29697047
Improved Determination of Subnuclear Position Enabled by Three-Dimensional Membrane Reconstruction. Zhao Y, Schreiner SM, Koo PK, Colombi P, King MC, Mochrie SG Biophysical journal 27410730 Biophys J 2016 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/27410730
TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe. Moravec M, Wischnewski H, Bah A, Hu Y, Liu N, Lafranchi L, King MC, Azzalin CM EMBO reports 27154402 EMBO Rep 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27154402
A comprehensive thalamocortical projection map at the mesoscopic level. Hunnicutt BJ, Long BR, Kusefoglu D, Gertz KJ, Zhong H, Mao T Nature neuroscience 25086607 Nat Neurosci 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25086607
Applying superresolution localization-based microscopy to neurons. Zhong H Synapse (New York, N.Y.) 25648102 Synapse 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25648102
Subdiffractive microscopy: techniques, applications, and challenges. Long BR, Robinson DC, Zhong H Wiley interdisciplinary reviews. Systems biology and medicine 24443323 Wiley Interdiscip Rev Syst Biol Med 2014 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/24443323
Live imaging of endogenous PSD-95 using ENABLED: a conditional strategy to fluorescently label endogenous proteins. Fortin DA, Tillo SE, Yang G, Rah JC, Melander JB, Bai S, Soler-Cedeño O, Qin M, Zemelman BV, Guo C, Mao T, Zhong H The Journal of neuroscience : the official journal of the Society for Neuroscience 25505322 J Neurosci 2014 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/25505322
A comprehensive excitatory input map of the striatum reveals novel functional organization. Hunnicutt BJ, Jongbloets BC, Birdsong WT, Gertz KJ, Zhong H, Mao T eLife 27892854 Elife 2016 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/27892854
Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates. Tillo SE, Xiong WH, Takahashi M, Miao S, Andrade AL, Fortin DA, Yang G, Qin M, Smoody BF, Stork PJS, Zhong H Cell reports 28423323 Cell Rep 2017 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/28423323
Measuring Caenorhabditis elegans life span in 96 well microtiter plates. Solis GM, Petrascheck M Journal of visualized experiments : JoVE 21445049 J Vis Exp 2011 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/21445049
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB 3rd, Salomon DR, Petrascheck M eLife 26623667 Elife 2015 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/26623667
Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. Solis GM, Kardakaris R, Valentine ER, Bar-Peled L, Chen AL, Blewett MM, McCormick MA, Williamson JR, Kennedy B, Cravatt BF, Petrascheck M eLife 30479271 Elife 2018 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/30479271
A pharmacological network for lifespan extension in Caenorhabditis elegans. Ye X, Linton JM, Schork NJ, Buck LB, Petrascheck M Aging cell 24134630 Aging Cell 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24134630
Pharmacological classes that extend lifespan of Caenorhabditis elegans. Carretero M, Gomez-Amaro RL, Petrascheck M Frontiers in genetics 25784926 Front Genet 2015 https://www.ncbi.nlm.nih.gov/pubmed/25784926
Proteostasis is differentially modulated by inhibition of translation initiation or elongation. Clay KJ, Yang Y, Clark C, Petrascheck M eLife 37795690 Elife 2023 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/37795690
Mood, stress and longevity: convergence on ANK3. Rangaraju S, Levey DF, Nho K, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, Niculescu AB Molecular psychiatry 27217151 Mol Psychiatry 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27217151
Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans. Gomez-Amaro RL, Valentine ER, Carretero M, LeBoeuf SE, Rangaraju S, Broaddus CD, Solis GM, Williamson JR, Petrascheck M Genetics 25903497 Genetics 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25903497
Computational Analysis of Lifespan Experiment Reproducibility. Petrascheck M, Miller DL Frontiers in genetics 28713422 Front Genet 2017 https://www.ncbi.nlm.nih.gov/pubmed/28713422
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J Nature 24828042 Nature 2014 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/24828042
High-throughput small-molecule screening in Caenorhabditis elegans. Rangaraju S, Solis GM, Petrascheck M Methods in molecular biology (Clifton, N.J.) 25618342 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25618342
The aging transcriptome: read between the lines. Perez-Gomez A, Buxbaum JN, Petrascheck M Current opinion in neurobiology 32563038 Curr Opin Neurobiol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32563038
A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Perez-Gomez A, Carretero M, Weber N, Peterka V, To A, Titova V, Solis G, Osborn O, Petrascheck M Nature communications 30532051 Nat Commun 2018 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/30532051
Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Rangaraju S, Solis GM, Andersson SI, Gomez-Amaro RL, Kardakaris R, Broaddus CD, Niculescu AB 3rd, Petrascheck M Aging cell 26255886 Aging Cell 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26255886
Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC Transgenic research 20352328 Transgenic Res 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/20352328
Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ PloS one 25397684 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25397684
Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR Journal of applied physiology (Bethesda, Md. : 1985) 26869713 J Appl Physiol (1985) 2016 May 1 https://www.ncbi.nlm.nih.gov/pubmed/26869713
Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A JCI insight 28931751 JCI Insight 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28931751
Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM Stem cell reports 28238794 Stem Cell Reports 2017 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/28238794
Nitric oxide production by glomerular podocytes. Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A Nitric oxide : biology and chemistry 29128399 Nitric Oxide 2018 Jan 30 https://www.ncbi.nlm.nih.gov/pubmed/29128399
Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats. Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr Hypertension (Dallas, Tex. : 1979) 25452472 Hypertension 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25452472
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23195032 FASEB J 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23195032
Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM American journal of physiology. Renal physiology 27465994 Am J Physiol Renal Physiol 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27465994
2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee Journal of cardiovascular translational research 25920443 J Cardiovasc Transl Res 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25920443
Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA Purinergic signalling 26385692 Purinergic Signal 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26385692
Rab38 modulates proteinuria in model of hypertension-associated renal disease. Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ Journal of the American Society of Nephrology : JASN 23291471 J Am Soc Nephrol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23291471
p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A The Journal of clinical investigation 27270176 J Clin Invest 2016 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/27270176
Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M Journal of the American Heart Association 26888427 J Am Heart Assoc 2016 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/26888427
Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O American journal of physiology. Renal physiology 28404591 Am J Physiol Renal Physiol 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28404591
Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons. Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z Nature protocols 24625778 Nat Protoc 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24625778
Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ American journal of physiology. Regulatory, integrative and comparative physiology 25540098 Am J Physiol Regul Integr Comp Physiol 2015 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/25540098
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ The Journal of biological chemistry 27226619 J Biol Chem 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27226619
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E Scientific reports 26915950 Sci Rep 2016 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/26915950
The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH American journal of physiology. Heart and circulatory physiology 26637559 Am J Physiol Heart Circ Physiol 2016 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/26637559
CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ Cancer research 25172839 Cancer Res 2014 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/25172839
Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM Proceedings of the National Academy of Sciences of the United States of America 25136115 Proc Natl Acad Sci U S A 2014 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/25136115
Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. Hegan PS, Ostertag E, Geurts AM, Mooseker MS Cytoskeleton (Hoboken, N.J.) 26446290 Cytoskeleton (Hoboken) 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26446290
A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A Journal of the American Society of Nephrology : JASN 29793963 J Am Soc Nephrol 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29793963
Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA Neuropharmacology 23791960 Neuropharmacology 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23791960
Identifying multiple causative genes at a single GWAS locus. Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C Genome research 24006081 Genome Res 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24006081
Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta. Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O Journal of visualized experiments : JoVE 26132549 J Vis Exp 2015 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/26132549
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. Wang C, Chung BC, Yan H, Wang HG, Lee SY, Pitt GS Nature communications 25232683 Nat Commun 2014 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/25232683
Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Wang C, Chung BC, Yan H, Lee SY, Pitt GS Structure (London, England : 1993) 22705208 Structure 2012 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/22705208
Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins. Pitt GS, Lee SY Protein science : a publication of the Protein Society 27262167 Protein Sci 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27262167
Cryo-electron microscopy structure of the TRPV2 ion channel. Zubcevic L, Herzik MA Jr, Chung BC, Liu Z, Lander GC, Lee SY Nature structural & molecular biology 26779611 Nat Struct Mol Biol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26779611
Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. Johnson ZL, Cheong CG, Lee SY Nature 22407322 Nature 2012 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/22407322
A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. Lee JH, Park CK, Chen G, Han Q, Xie RG, Liu T, Ji RR, Lee SY Cell 24856969 Cell 2014 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/24856969
Molecular mechanisms of robustness in plants. Lempe J, Lachowiec J, Sullivan AM, Queitsch C Current opinion in plant biology 23279801 Curr Opin Plant Biol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23279801
Corrigendum: MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals. Carlson KD, Sudmant PH, Press MO, Eichler EE, Shendure J, Queitsch C Genome research 26240161 Genome Res 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26240161
Variability in a Short Tandem Repeat Mediates Complex Epistatic Interactions in Arabidopsis thaliana. Press MO, Queitsch C Genetics 27866166 Genetics 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27866166
Massive variation of short tandem repeats with functional consequences across strains of Arabidopsis thaliana. Press MO, McCoy RC, Hall AN, Akey JM, Queitsch C Genome research 29970452 Genome Res 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29970452
Redundancy, Feedback, and Robustness in the Arabidopsis thaliana BZR/BEH Gene Family. Lachowiec J, Mason GA, Schultz K, Queitsch C Frontiers in genetics 30542366 Front Genet 2018 https://www.ncbi.nlm.nih.gov/pubmed/30542366
HSP90 Contributes to Entrainment of the Arabidopsis Circadian Clock via the Morning Loop. Davis AM, Ronald J, Ma Z, Wilkinson AJ, Philippou K, Shindo T, Queitsch C, Davis SJ Genetics 30337341 Genetics 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30337341
PIF4 and ELF3 Act Independently in Arabidopsis thaliana Thermoresponsive Flowering. Press MO, Lanctot A, Queitsch C PloS one 27564448 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27564448
The protein chaperone HSP90 can facilitate the divergence of gene duplicates. Lachowiec J, Lemus T, Thomas JH, Murphy PJ, Nemhauser JL, Queitsch C Genetics 23410833 Genetics 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23410833
Molecular mechanisms governing differential robustness of development and environmental responses in plants. Lachowiec J, Queitsch C, Kliebenstein DJ Annals of botany 26473020 Ann Bot 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26473020
Medicine. Combating evolution to fight disease. Rosenberg SM, Queitsch C Science (New York, N.Y.) 24604189 Science 2014 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/24604189
Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. Xia J, Chiu LY, Nehring RB, Bravo Núñez MA, Mei Q, Perez M, Zhai Y, Fitzgerald DM, Pribis JP, Wang Y, Hu CW, Powell RT, LaBonte SA, Jalali A, Matadamas Guzmán ML, Lentzsch AM, Szafran AT, Joshi MC, Richters M, Gibson JL, Frisch RL, Hastings PJ, Bates D, Queitsch C, Hilsenbeck SG, Coarfa C, Hu JC, Siegele DA, Scott KL, Liang H, Mancini MA, Herman C, Miller KM, Rosenberg SM Cell 30633903 Cell 2019 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/30633903
It's not magic - Hsp90 and its effects on genetic and epigenetic variation. Zabinsky RA, Mason GA, Queitsch C, Jarosz DF Seminars in cell & developmental biology 29807130 Semin Cell Dev Biol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/29807130
AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana. Lemus T, Mason GA, Bubb KL, Alexandre CM, Queitsch C, Cuperus JT Genetics 36303325 Genetics 2023 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/36303325
Lessons from model organisms: phenotypic robustness and missing heritability in complex disease. Queitsch C, Carlson KD, Girirajan S PLoS genetics 23166511 PLoS Genet 2012 https://www.ncbi.nlm.nih.gov/pubmed/23166511
Evolutionary assembly patterns of prokaryotic genomes. Press MO, Queitsch C, Borenstein E Genome research 27197212 Genome Res 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27197212
MIPSTR: a method for multiplex genotyping of germline and somatic STR variation across many individuals. Carlson KD, Sudmant PH, Press MO, Eichler EE, Shendure J, Queitsch C Genome research 25659649 Genome Res 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25659649
The conserved PFT1 tandem repeat is crucial for proper flowering in Arabidopsis thaliana. Rival P, Press MO, Bale J, Grancharova T, Undurraga SF, Queitsch C Genetics 25116137 Genetics 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25116137
The overdue promise of short tandem repeat variation for heritability. Press MO, Carlson KD, Queitsch C Trends in genetics : TIG 25182195 Trends Genet 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25182195
A Genome-Wide Association Analysis Reveals Epistatic Cancellation of Additive Genetic Variance for Root Length in Arabidopsis thaliana. Lachowiec J, Shen X, Queitsch C, Carlborg Ö PLoS genetics 26397943 PLoS Genet 2015 https://www.ncbi.nlm.nih.gov/pubmed/26397943
Hsp90 promotes kinase evolution. Lachowiec J, Lemus T, Borenstein E, Queitsch C Molecular biology and evolution 25246701 Mol Biol Evol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25246701
The Mechanistic Underpinnings of an ago1-Mediated, Environmentally Dependent, and Stochastic Phenotype. Mason GA, Lemus T, Queitsch C Plant physiology 26872948 Plant Physiol 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26872948
Genome-scale co-evolutionary inference identifies functions and clients of bacterial Hsp90. Press MO, Li H, Creanza N, Kramer G, Queitsch C, Sourjik V, Borenstein E PLoS genetics 23874229 PLoS Genet 2013 https://www.ncbi.nlm.nih.gov/pubmed/23874229
Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3. Undurraga SF, Press MO, Legendre M, Bujdoso N, Bale J, Wang H, Davis SJ, Verstrepen KJ, Queitsch C Proceedings of the National Academy of Sciences of the United States of America 23129635 Proc Natl Acad Sci U S A 2012 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/23129635
GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris. Liachko I, Youngblood RA, Tsui K, Bubb KL, Queitsch C, Raghuraman MK, Nislow C, Brewer BJ, Dunham MJ PLoS genetics 24603708 PLoS Genet 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24603708
Bacterial cell wall composition and the influence of antibiotics by cell-wall and whole-cell NMR. Romaniuk JA, Cegelski L Philosophical transactions of the Royal Society of London. Series B, Biological sciences 26370936 Philos Trans R Soc Lond B Biol Sci 2015 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/26370936
Spectral snapshots of bacterial cell-wall composition and the influence of antibiotics by whole-cell NMR. Nygaard R, Romaniuk JAH, Rice DM, Cegelski L Biophysical journal 25809251 Biophys J 2015 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/25809251
Molecular determinants of mechanical properties of V. cholerae biofilms at the air-liquid interface. Hollenbeck EC, Fong JC, Lim JY, Yildiz FH, Fuller GG, Cegelski L Biophysical journal 25418293 Biophys J 2014 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/25418293
Bottom-up and top-down solid-state NMR approaches for bacterial biofilm matrix composition. Cegelski L Journal of magnetic resonance (San Diego, Calif. : 1997) 25797008 J Magn Reson 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25797008
Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy. Loy BA, Lesser AB, Staveness D, Billingsley KL, Cegelski L, Wender PA Journal of the American Chemical Society 25710634 J Am Chem Soc 2015 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/25710634
Analysis of the Aspergillus fumigatus Biofilm Extracellular Matrix by Solid-State Nuclear Magnetic Resonance Spectroscopy. Reichhardt C, Ferreira JA, Joubert LM, Clemons KV, Stevens DA, Cegelski L Eukaryotic cell 26163318 Eukaryot Cell 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26163318
Curcumin as an amyloid-indicator dye in E. coli. McCrate OA, Zhou X, Cegelski L Chemical communications (Cambridge, England) 23287899 Chem Commun (Camb) 2013 May 14 https://www.ncbi.nlm.nih.gov/pubmed/23287899
Dimethyl sulfoxide and ethanol elicit increased amyloid biogenesis and amyloid-integrated biofilm formation in Escherichia coli. Lim JY, May JM, Cegelski L Applied and environmental microbiology 22389366 Appl Environ Microbiol 2012 May https://www.ncbi.nlm.nih.gov/pubmed/22389366
Nutrient-dependent structural changes in S. aureus peptidoglycan revealed by solid-state NMR spectroscopy. Zhou X, Cegelski L Biochemistry 22974326 Biochemistry 2012 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/22974326
Quantitative analysis of amyloid-integrated biofilms formed by uropathogenic Escherichia coli at the air-liquid interface. Wu C, Lim JY, Fuller GG, Cegelski L Biophysical journal 22947862 Biophys J 2012 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/22947862
REDOR NMR for drug discovery. Cegelski L Bioorganic & medicinal chemistry letters 24035486 Bioorg Med Chem Lett 2013 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/24035486
Sum of the parts: composition and architecture of the bacterial extracellular matrix. McCrate OA, Zhou X, Reichhardt C, Cegelski L Journal of molecular biology 23827139 J Mol Biol 2013 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/23827139
Disruption of Escherichia coli amyloid-integrated biofilm formation at the air-liquid interface by a polysorbate surfactant. Wu C, Lim JY, Fuller GG, Cegelski L Langmuir : the ACS journal of surfaces and colloids 23259693 Langmuir 2013 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/23259693
Solid-State NMR for Bacterial Biofilms. Reichhardt C, Cegelski L Molecular physics 24976646 Mol Phys 2014 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/24976646
Characterization of the Vibrio cholerae extracellular matrix: a top-down solid-state NMR approach. Reichhardt C, Fong JC, Yildiz F, Cegelski L Biochimica et biophysica acta 24911407 Biochim Biophys Acta 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/24911407
Cell-Based High-Throughput Screening Identifies Rifapentine as an Inhibitor of Amyloid and Biofilm Formation in Escherichia coli. Maher MC, Lim JY, Gunawan C, Cegelski L ACS infectious diseases 27623312 ACS Infect Dis 2015 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/27623312
Putative hydrogen bond to tyrosine M208 in photosynthetic reaction centers from Rhodobacter capsulatus significantly slows primary charge separation. Saggu M, Carter B, Zhou X, Faries K, Cegelski L, Holten D, Boxer SG, Kirmaier C The journal of physical chemistry. B 24902471 J Phys Chem B 2014 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/24902471
Frequency-selective REDOR and spin-diffusion relays in uniformly labeled whole cells. Rice DM, Romaniuk JA, Cegelski L Solid state nuclear magnetic resonance 26493462 Solid State Nucl Magn Reson 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26493462
Community behavior and amyloid-associated phenotypes among a panel of uropathogenic E. coli. Lim JY, Pinkner JS, Cegelski L Biochemical and biophysical research communications 24239885 Biochem Biophys Res Commun 2014 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/24239885
Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease. Braun TA, Mullins RF, Wagner AH, Andorf JL, Johnston RM, Bakall BB, Deluca AP, Fishman GA, Lam BL, Weleber RG, Cideciyan AV, Jacobson SG, Sheffield VC, Tucker BA, Stone EM Human molecular genetics 23918662 Hum Mol Genet 2013 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/23918662
Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis. Drivas TG, Wojno AP, Tucker BA, Stone EM, Bennett J Science translational medicine 26062849 Sci Transl Med 2015 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/26062849
Intravesical and alternative bladder-preservation therapies in the management of non-muscle-invasive bladder cancer unresponsive to bacillus Calmette-Guérin. Steinberg RL, Thomas LJ, Nepple KG Urologic oncology 26777259 Urol Oncol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26777259
Perception of patient appearance following various methods of reconstruction after orbital exenteration. Kuiper JJ, Zimmerman MB, Pagedar NA, Carter KD, Allen RC, Shriver EM Orbit (Amsterdam, Netherlands) 27341072 Orbit 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27341072
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells. Ozden O, Park SH, Wagner BA, Song HY, Zhu Y, Vassilopoulos A, Jung B, Buettner GR, Gius D Free radical biology & medicine 25152236 Free Radic Biol Med 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25152236
Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma. Tucker BA, Solivan-Timpe F, Roos BR, Anfinson KR, Robin AL, Wiley LA, Mullins RF, Fingert JH Journal of stem cell research & therapy 24883232 J Stem Cell Res Ther 2014 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/24883232
ABCB5 is a limbal stem cell gene required for corneal development and repair. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY Nature 25030174 Nature 2014 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/25030174
Loss of CD34 expression in aging human choriocapillaris endothelial cells. Sohn EH, Flamme-Wiese MJ, Whitmore SS, Wang K, Tucker BA, Mullins RF PloS one 24466138 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24466138
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Whitmore SS, Sohn EH, Chirco KR, Drack AV, Stone EM, Tucker BA, Mullins RF Progress in retinal and eye research 25486088 Prog Retin Eye Res 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25486088
Use of the Teres Major Muscle in Chimeric Subscapular System Free Flaps for Head and Neck Reconstruction. Tomlinson AR, Jameson MJ, Pagedar NA, Schoeff SS, Shearer AE, Boyd NH JAMA otolaryngology-- head & neck surgery 26312435 JAMA Otolaryngol Head Neck Surg 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26312435
Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration. Zeng S, Whitmore SS, Sohn EH, Riker MJ, Wiley LA, Scheetz TE, Stone EM, Tucker BA, Mullins RF The Journal of pathology 26564985 J Pathol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26564985
Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa. Tucker BA, Mullins RF, Streb LM, Anfinson K, Eyestone ME, Kaalberg E, Riker MJ, Drack AV, Braun TA, Stone EM eLife 23991284 Elife 2013 Aug 27 https://www.ncbi.nlm.nih.gov/pubmed/23991284
Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study. Sohn EH, Jiao C, Kaalberg E, Cranston C, Mullins RF, Stone EM, Tucker BA Scientific reports 26138532 Sci Rep 2015 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/26138532
Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Tucker BA, Scheetz TE, Mullins RF, DeLuca AP, Hoffmann JM, Johnston RM, Jacobson SG, Sheffield VC, Stone EM Proceedings of the National Academy of Sciences of the United States of America 21825139 Proc Natl Acad Sci U S A 2011 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/21825139
Weight loss after head and neck cancer: A dynamic relationship with depressive symptoms. Van Liew JR, Brock RL, Christensen AJ, Karnell LH, Pagedar NA, Funk GF Head & neck 27704695 Head Neck 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27704695
Sources of bias in peoples' social-comparative estimates of food consumption. Scherer AM, Bruchmann K, Windschitl PD, Rose JP, Smith AR, Koestner B, Snetselaar L, Suls J Journal of experimental psychology. Applied 27054551 J Exp Psychol Appl 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27054551
Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database. Duchman KR, Gao Y, Miller BJ Cancer epidemiology 26002013 Cancer Epidemiol 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26002013
A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids. Wiley LA, Beebe DC, Mullins RF, Stone EM, Tucker BA Current protocols in stem cell biology 27171793 Curr Protoc Stem Cell Biol 2016 May 12 https://www.ncbi.nlm.nih.gov/pubmed/27171793
Photoreceptor cells with profound structural deficits can support useful vision in mice. Thompson S, Blodi FR, Lee S, Welder CR, Mullins RF, Tucker BA, Stasheff SF, Stone EM Investigative ophthalmology & visual science 24569582 Invest Ophthalmol Vis Sci 2014 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/24569582
Stem cells as tools for studying the genetics of inherited retinal degenerations. Wiley LA, Burnight ER, Mullins RF, Stone EM, Tucker BA Cold Spring Harbor perspectives in medicine 25502747 Cold Spring Harb Perspect Med 2014 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/25502747
CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype. Burnight ER, Wiley LA, Drack AV, Braun TA, Anfinson KR, Kaalberg EE, Halder JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA Gene therapy 24807808 Gene Ther 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24807808
Prevascularized silicon membranes for the enhancement of transport to implanted medical devices. Worthington KS, Wiley LA, Mullins RF, Tucker BA, Nuxoll E Journal of biomedical materials research. Part B, Applied biomaterials 26316050 J Biomed Mater Res B Appl Biomater 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/26316050
Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012. Khaja SF, Hoffman HT, Pagedar NA The Annals of otology, rhinology, and laryngology 26481178 Ann Otol Rhinol Laryngol 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26481178
Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC Human molecular genetics 26494905 Hum Mol Genet 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26494905
Influence of a loop electrosurgical excision procedure (LEEP) on levels of cytokines in cervical secretions. Saftlas AF, Spracklen CN, Ryckman KK, Stockdale CK, Penrose K, Ault K, Rubenstein LM, Pinto LA Journal of reproductive immunology 25721621 J Reprod Immunol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25721621
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease. Giacalone JC, Wiley LA, Burnight ER, Songstad AE, Mullins RF, Stone EM, Tucker BA Stem cells translational medicine 26683869 Stem Cells Transl Med 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26683869
Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq. Whitmore SS, Wagner AH, DeLuca AP, Drack AV, Stone EM, Tucker BA, Zeng S, Braun TA, Mullins RF, Scheetz TE Experimental eye research 25446321 Exp Eye Res 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25446321
The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. Mullins RF, Schoo DP, Sohn EH, Flamme-Wiese MJ, Workamelahu G, Johnston RM, Wang K, Tucker BA, Stone EM The American journal of pathology 25204844 Am J Pathol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25204844
Gene therapy using stem cells. Burnight ER, Wiley LA, Mullins RF, Stone EM, Tucker BA Cold Spring Harbor perspectives in medicine 25395375 Cold Spring Harb Perspect Med 2014 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/25395375
Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial. Tucker BA, Cranston CM, Anfinson KA, Shrestha S, Streb LM, Leon A, Mullins RF, Stone EM Translational research : the journal of laboratory and clinical medicine 26364624 Transl Res 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26364624
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration. Songstad AE, Wiley LA, Duong K, Kaalberg E, Flamme-Wiese MJ, Cranston CM, Riker MJ, Levasseur D, Stone EM, Mullins RF, Tucker BA Investigative ophthalmology & visual science 26720480 Invest Ophthalmol Vis Sci 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26720480
Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds. Worthington KS, Wiley LA, Guymon CA, Salem AK, Tucker BA Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 26692377 J Ocul Pharmacol Ther 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26692377
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness. Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, Penticoff JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA Scientific reports 27471043 Sci Rep 2016 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/27471043
Risk of recurrent preterm birth among women according to change in partner. Baer RJ, Yang J, Chambers CD, Ryckman KK, Saftlas AF, Berghella V, Schetter CD, Shaw GM, Stevenson DK, Jelliffe-Pawlowski LL Journal of perinatal medicine 27718495 J Perinat Med 2017 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/27718495
Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Tucker BA, Anfinson KR, Mullins RF, Stone EM, Young MJ Stem cells translational medicine 23283489 Stem Cells Transl Med 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23283489
Is age-related macular degeneration a microvascular disease? Mullins RF, Khanna A, Schoo DP, Tucker BA, Sohn EH, Drack AV, Stone EM Advances in experimental medicine and biology 24664709 Adv Exp Med Biol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24664709
Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy. Boye SE, Huang WC, Roman AJ, Sumaroka A, Boye SL, Ryals RC, Olivares MB, Ruan Q, Tucker BA, Stone EM, Swaroop A, Cideciyan AV, Hauswirth WW, Jacobson SG PloS one 24671090 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24671090
Stem cells for investigation and treatment of inherited retinal disease. Tucker BA, Mullins RF, Stone EM Human molecular genetics 24647603 Hum Mol Genet 2014 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/24647603
Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Baranov PY, Tucker BA, Young MJ Tissue engineering. Part A 24320879 Tissue Eng Part A 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24320879
Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices. Do AV, Worthington KS, Tucker BA, Salem AK International journal of pharmaceutics 30268853 Int J Pharm 2018 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/30268853
Structural and biochemical analyses of choroidal thickness in human donor eyes. Sohn EH, Khanna A, Tucker BA, Abràmoff MD, Stone EM, Mullins RF Investigative ophthalmology & visual science 24519422 Invest Ophthalmol Vis Sci 2014 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/24519422
Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases. Wiley LA, Burnight ER, Songstad AE, Drack AV, Mullins RF, Stone EM, Tucker BA Progress in retinal and eye research 25448922 Prog Retin Eye Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25448922
Mechanical properties of murine and porcine ocular tissues in compression. Worthington KS, Wiley LA, Bartlett AM, Stone EM, Mullins RF, Salem AK, Guymon CA, Tucker BA Experimental eye research 24613781 Exp Eye Res 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24613781
Vending Assessment and Program Implementation in Four Iowa Worksites. Lillehoj CJ, Nothwehr F, Shipley K, Voss C Health promotion practice 26220278 Health Promot Pract 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26220278
Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate. Worthington KS, Do AV, Smith R, Tucker BA, Salem AK Macromolecular bioscience 30430755 Macromol Biosci 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30430755
Integration of solid-state nanopores in a 0.5 μm CMOS foundry process. Uddin A, Yemenicioglu S, Chen CH, Corigliano E, Milaninia K, Theogarajan L Nanotechnology 23519330 Nanotechnology 2013 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/23519330
Velocity profiles in pores with undulating opening diameter and their importance for resistive-pulse experiments. Innes LM, Chen CH, Schiel M, Pevarnik M, Haurais F, Toimil-Molares ME, Vlassiouk I, Theogarajan L, Siwy ZS Analytical chemistry 25245282 Anal Chem 2014 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/25245282
Clickable Amphiphilic Triblock Copolymers. Isaacman MJ, Barron KA, Theogarajan LS Journal of polymer science. Part A, Polymer chemistry 23100856 J Polym Sci A Polym Chem 2012 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/23100856
Stealth polymeric vesicles via metal-free click coupling. Isaacman MJ, Corigliano EM, Theogarajan LS Biomacromolecules 23952743 Biomacromolecules 2013 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/23952743
Solid-state nanopore based biomimetic voltage gated ion channels. Pevarnik M, Cui W, Yemenicioglu S, Rofeh J, Theogarajan L Bioinspiration & biomimetics 28726670 Bioinspir Biomim 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/28726670
Tailored Polymeric Membranes for Mycobacterium Smegmatis Porin A (MspA) Based Biosensors. Morton D, Mortezaei S, Yemenicioglu S, Isaacman MJ, Nova IC, Gundlach JH, Theogarajan L Journal of materials chemistry. B 26413301 J Mater Chem B 2015 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/26413301
Rapid Metal -free Macromolecular Coupling via in situ Nitrile Oxide-Activated Alkene Cycloaddition. Isaacman MJ, Cui W, Theogarajan LS Journal of polymer science. Part A, Polymer chemistry 26811566 J Polym Sci A Polym Chem 2014 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/26811566
Wafer Scale Integration of CMOS Chips for Biomedical Applications via Self-Aligned Masking. Uddin A, Milaninia K, Chen CH, Theogarajan L IEEE transactions on components, packaging, and manufacturing technology 22400126 IEEE Trans Compon Packaging Manuf Technol 2011 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/22400126
A CMOS enhanced solid-state nanopore based single molecule detection platform. Chen C, Yemenicioglu S, Uddin A, Corgliano E, Theogarajan L Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 24109650 Annu Int Conf IEEE Eng Med Biol Soc 2013 https://www.ncbi.nlm.nih.gov/pubmed/24109650
In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC Nature 23783515 Nature 2013 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/23783515
Zebrafish cardiac injury and regeneration models: a noninvasive and invasive in vivo model of cardiac regeneration. Dickover MS, Zhang R, Han P, Chi NC Methods in molecular biology (Clifton, N.J.) 24029953 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/24029953
The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dickover M, Hegarty JM, Ly K, Lopez D, Yang H, Zhang R, Tedeschi N, Hsiai TK, Chi NC Developmental biology 24607366 Dev Biol 2014 May 15 https://www.ncbi.nlm.nih.gov/pubmed/24607366
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Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss LA, Tidyman WE, Klein OD, Rauen KA Clinical genetics 22946697 Clin Genet 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/22946697
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Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD Stem cell reports 27569062 Stem Cell Reports 2016 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/27569062
Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM The Journal of neuroscience : the official journal of the Society for Neuroscience 26740656 J Neurosci 2016 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/26740656
Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT). Morris SM, Acosta MT, Garg S, Green J, Huson S, Legius E, North KN, Payne JM, Plasschaert E, Frazier TW, Weiss LA, Zhang Y, Gutmann DH, Constantino JN JAMA psychiatry 27760236 JAMA Psychiatry 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27760236
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Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA Cell reports 29212016 Cell Rep 2017 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/29212016
Dysregulation of astrocyte extracellular signaling in Costello syndrome. Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM Science translational medicine 25947161 Sci Transl Med 2015 May 6 https://www.ncbi.nlm.nih.gov/pubmed/25947161
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. Yeh E, Dao DQ, Wu ZY, Kandalam SM, Camacho FM, Tom C, Zhang W, Krencik R, Rauen KA, Ullian EM, Weiss LA Molecular psychiatry 29158583 Mol Psychiatry 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29158583
Origins and formation of histone methylation across the human cell cycle. Zee BM, Britton LM, Wolle D, Haberman DM, Garcia BA Molecular and cellular biology 22547680 Mol Cell Biol 2012 Jul https://www.ncbi.nlm.nih.gov/pubmed/22547680
Large-scale global identification of protein lysine methylation in vivo. Cao XJ, Arnaudo AM, Garcia BA Epigenetics 23644510 Epigenetics 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23644510
Combining genomic and proteomic approaches for epigenetics research. Han Y, Garcia BA Epigenomics 23895656 Epigenomics 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23895656
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Sridharan R, Gonzales-Cope M, Chronis C, Bonora G, McKee R, Huang C, Patel S, Lopez D, Mishra N, Pellegrini M, Carey M, Garcia BA, Plath K Nature cell biology 23748610 Nat Cell Biol 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23748610
Comprehending dynamic protein methylation with mass spectrometry. Afjehi-Sadat L, Garcia BA Current opinion in chemical biology 23333572 Curr Opin Chem Biol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23333572
Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI Nature structural & molecular biology 23295261 Nat Struct Mol Biol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23295261
Examining histone posttranslational modification patterns by high-resolution mass spectrometry. Lin S, Garcia BA Methods in enzymology 22910200 Methods Enzymol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22910200
Asymmetrically modified nucleosomes. Voigt P, LeRoy G, Drury WJ 3rd, Zee BM, Son J, Beck DB, Young NL, Garcia BA, Reinberg D Cell 23021224 Cell 2012 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/23021224
Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Rothbart SB, Lin S, Britton LM, Krajewski K, Keogh MC, Garcia BA, Strahl BD Scientific reports 22761995 Sci Rep 2012 https://www.ncbi.nlm.nih.gov/pubmed/22761995
Global turnover of histone post-translational modifications and variants in human cells. Zee BM, Levin RS, DiMaggio PA, Garcia BA Epigenetics & chromatin 21134274 Epigenetics Chromatin 2010 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/21134274
Revealing histone variant induced changes via quantitative proteomics. Arnaudo AM, Molden RC, Garcia BA Critical reviews in biochemistry and molecular biology 21526979 Crit Rev Biochem Mol Biol 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21526979
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, Kruger RG Epigenetics 22419068 Epigenetics 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22419068
Proteomic interrogation of human chromatin. Torrente MP, Zee BM, Young NL, Baliban RC, LeRoy G, Floudas CA, Hake SB, Garcia BA PloS one 21935452 PLoS One 2011 https://www.ncbi.nlm.nih.gov/pubmed/21935452
Low Resolution Data-Independent Acquisition in an LTQ-Orbitrap Allows for Simplified and Fully Untargeted Analysis of Histone Modifications. Sidoli S, Simithy J, Karch KR, Kulej K, Garcia BA Analytical chemistry 26505526 Anal Chem 2015 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/26505526
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG Nature medicine 26366710 Nat Med 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26366710
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG Blood 25395428 Blood 2015 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/25395428
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW Science (New York, N.Y.) 27174990 Science 2016 May 13 https://www.ncbi.nlm.nih.gov/pubmed/27174990
Complete Workflow for Analysis of Histone Post-translational Modifications Using Bottom-up Mass Spectrometry: From Histone Extraction to Data Analysis. Sidoli S, Bhanu NV, Karch KR, Wang X, Garcia BA Journal of visualized experiments : JoVE 27286567 J Vis Exp 2016 May 17 https://www.ncbi.nlm.nih.gov/pubmed/27286567
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW Nature communications 31086175 Nat Commun 2019 May 13 https://www.ncbi.nlm.nih.gov/pubmed/31086175
High resolution is not a strict requirement for characterization and quantification of histone post-translational modifications. Karch KR, Zee BM, Garcia BA Journal of proteome research 25325711 J Proteome Res 2014 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/25325711
Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry. Lin S, Wein S, Gonzales-Cope M, Otte GL, Yuan ZF, Afjehi-Sadat L, Maile T, Berger SL, Rush J, Lill JR, Arnott D, Garcia BA Molecular & cellular proteomics : MCP 25000943 Mol Cell Proteomics 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25000943
Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications. Molden RC, Bhanu NV, LeRoy G, Arnaudo AM, Garcia BA Epigenetics & chromatin 25922622 Epigenetics Chromatin 2015 https://www.ncbi.nlm.nih.gov/pubmed/25922622
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2. Garrigues JM, Sidoli S, Garcia BA, Strome S Genome research 25467431 Genome Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25467431
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Kang S, Tsai LT, Zhou Y, Evertts A, Xu S, Griffin MJ, Issner R, Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, Rosen ED Nature cell biology 25503565 Nat Cell Biol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25503565
Quantitative proteomic analysis of histone modifications. Huang H, Lin S, Garcia BA, Zhao Y Chemical reviews 25688442 Chem Rev 2015 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/25688442
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF Nature 22722849 Nature 2012 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/22722849
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Chicas A, Kapoor A, Wang X, Aksoy O, Evertts AG, Zhang MQ, Garcia BA, Bernstein E, Lowe SW Proceedings of the National Academy of Sciences of the United States of America 22615382 Proc Natl Acad Sci U S A 2012 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/22615382
Global secretome analysis identifies novel mediators of bone metastasis. Blanco MA, LeRoy G, Khan Z, Alečković M, Zee BM, Garcia BA, Kang Y Cell research 22688892 Cell Res 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22688892
A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics. Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA Molecular & cellular proteomics : MCP 27114449 Mol Cell Proteomics 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27114449
Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation. Cao XJ, Zee BM, Garcia BA Methods in molecular biology (Clifton, N.J.) 23436372 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23436372
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Gaspar-Maia A, Qadeer ZA, Hasson D, Ratnakumar K, Leu NA, Leroy G, Liu S, Costanzi C, Valle-Garcia D, Schaniel C, Lemischka I, Garcia B, Pehrson JR, Bernstein E Nature communications 23463008 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23463008
Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins. LeRoy G, Chepelev I, DiMaggio PA, Blanco MA, Zee BM, Zhao K, Garcia BA Genome biology 22897906 Genome Biol 2012 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/22897906
Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression. Peixoto LL, Wimmer ME, Poplawski SG, Tudor JC, Kenworthy CA, Liu S, Mizuno K, Garcia BA, Zhang NR, Giese K, Abel T BMC genomics 26040834 BMC Genomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26040834
H3R42me2a is a histone modification with positive transcriptional effects. Casadio F, Lu X, Pollock SB, LeRoy G, Garcia BA, Muir TW, Roeder RG, Allis CD Proceedings of the National Academy of Sciences of the United States of America 23980157 Proc Natl Acad Sci U S A 2013 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/23980157
SnapShot: histone modifications. Huang H, Sabari BR, Garcia BA, Allis CD, Zhao Y Cell 25303536 Cell 2014 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/25303536
Middle-Down and Top-Down Mass Spectrometric Analysis of Co-occurring Histone Modifications. Molden RC, Garcia BA Current protocols in protein science 25081742 Curr Protoc Protein Sci 2014 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/25081742
A proteomic glimpse into the initial global epigenetic changes during HIV infection. Britton LM, Sova P, Belisle S, Liu S, Chan EY, Katze MG, Garcia BA Proteomics 25116026 Proteomics 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25116026
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression. Jain SU, Khazaei S, Marchione DM, Lundgren SM, Wang X, Weinberg DN, Deshmukh S, Juretic N, Lu C, Allis CD, Garcia BA, Jabado N, Lewis PW Proceedings of the National Academy of Sciences of the United States of America 33067396 Proc Natl Acad Sci U S A 2020 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/33067396
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O Nature 24847881 Nature 2014 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/24847881
Quantitative proteomic discovery of dynamic epigenome changes that control human cytomegalovirus (HCMV) infection. O'Connor CM, DiMaggio PA Jr, Shenk T, Garcia BA Molecular & cellular proteomics : MCP 24987098 Mol Cell Proteomics 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/24987098
In vivo proximity labeling for the detection of protein-protein and protein-RNA interactions. Beck DB, Narendra V, Drury WJ 3rd, Casey R, Jansen PW, Yuan ZF, Garcia BA, Vermeulen M, Bonasio R Journal of proteome research 25311790 J Proteome Res 2014 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/25311790
Evaluation of proteomic search engines for the analysis of histone modifications. Yuan ZF, Lin S, Molden RC, Garcia BA Journal of proteome research 25167464 J Proteome Res 2014 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/25167464
Quantitative dynamics of the link between cellular metabolism and histone acetylation. Evertts AG, Zee BM, Dimaggio PA, Gonzales-Cope M, Coller HA, Garcia BA The Journal of biological chemistry 23482559 J Biol Chem 2013 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/23482559
Validation of protein acetylation by mass spectrometry. Zee BM, Garcia BA Methods in molecular biology (Clifton, N.J.) 23381849 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23381849
SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Binda O, Sevilla A, LeRoy G, Lemischka IR, Garcia BA, Richard S Epigenetics 23324626 Epigenetics 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23324626
Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. Wu Y, DiMaggio PA Jr, Perlman DH, Zakian VA, Garcia BA Journal of proteome research 23181431 J Proteome Res 2013 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/23181431
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD Science (New York, N.Y.) 23539183 Science 2013 May 17 https://www.ncbi.nlm.nih.gov/pubmed/23539183
Discovery of lysine post-translational modifications through mass spectrometric detection. Zee BM, Garcia BA Essays in biochemistry 22708569 Essays Biochem 2012 https://www.ncbi.nlm.nih.gov/pubmed/22708569
Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Green EM, Mas G, Young NL, Garcia BA, Gozani O Nature structural & molecular biology 22343720 Nat Struct Mol Biol 2012 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/22343720
Quantitative proteomic approaches to studying histone modifications. Zee BM, Young NL, Garcia BA Current chemical genomics 21966350 Curr Chem Genomics 2011 https://www.ncbi.nlm.nih.gov/pubmed/21966350
H4K20 methylation regulates quiescence and chromatin compaction. Evertts AG, Manning AL, Wang X, Dyson NJ, Garcia BA, Coller HA Molecular biology of the cell 23924899 Mol Biol Cell 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23924899
Initial characterization of histone H3 serine 10 O-acetylation. Britton LM, Newhart A, Bhanu NV, Sridharan R, Gonzales-Cope M, Plath K, Janicki SM, Garcia BA Epigenetics 23949383 Epigenetics 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23949383
Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications. Vasudevan D, Hickok JR, Bovee RC, Pham V, Mantell LL, Bahroos N, Kanabar P, Cao XJ, Maienschein-Cline M, Garcia BA, Thomas DD Cancer research 26542213 Cancer Res 2015 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/26542213
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE Cell metabolism 24998913 Cell Metab 2014 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/24998913
EpiProfile Quantifies Histone Peptides With Modifications by Extracting Retention Time and Intensity in High-resolution Mass Spectra. Yuan ZF, Lin S, Molden RC, Cao XJ, Bhanu NV, Wang X, Sidoli S, Liu S, Garcia BA Molecular & cellular proteomics : MCP 25805797 Mol Cell Proteomics 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25805797
The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Wu L, Zee BM, Wang Y, Garcia BA, Dou Y Molecular cell 21726816 Mol Cell 2011 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/21726816
Breaking the histone code with quantitative mass spectrometry. Britton LM, Gonzales-Cope M, Zee BM, Garcia BA Expert review of proteomics 21999833 Expert Rev Proteomics 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21999833
Post-Translational Modification Profiling--a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Merbl Y, Kirschner MW Current protocols in protein science 25081743 Curr Protoc Protein Sci 2014 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/25081743
Proteomic characterization of novel histone post-translational modifications. Arnaudo AM, Garcia BA Epigenetics & chromatin 23916056 Epigenetics Chromatin 2013 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/23916056
Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells. Gonzales-Cope M, Sidoli S, Bhanu NV, Won KJ, Garcia BA BMC genomics 26847871 BMC Genomics 2016 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/26847871
Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations. Önder Ö, Sidoli S, Carroll M, Garcia BA Expert review of proteomics 26400466 Expert Rev Proteomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26400466
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O Molecular cell 22099308 Mol Cell 2011 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/22099308
BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K Nature structural & molecular biology 25383670 Nat Struct Mol Biol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25383670
Mass spectrometric analysis of histone proteoforms. Yuan ZF, Arnaudo AM, Garcia BA Annual review of analytical chemistry (Palo Alto, Calif.) 24896311 Annu Rev Anal Chem (Palo Alto Calif) 2014 https://www.ncbi.nlm.nih.gov/pubmed/24896311
Drawbacks in the use of unconventional hydrophobic anhydrides for histone derivatization in bottom-up proteomics PTM analysis. Sidoli S, Yuan ZF, Lin S, Karch K, Wang X, Bhanu N, Arnaudo AM, Britton LM, Cao XJ, Gonzales-Cope M, Han Y, Liu S, Molden RC, Wein S, Afjehi-Sadat L, Garcia BA Proteomics 25641854 Proteomics 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25641854
Characterization of BRD4 during mammalian postmeiotic sperm development. Bryant JM, Donahue G, Wang X, Meyer-Ficca M, Luense LJ, Weller AH, Bartolomei MS, Blobel GA, Meyer RG, Garcia BA, Berger SL Molecular and cellular biology 25691659 Mol Cell Biol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25691659
De novo peptide design and experimental validation of histone methyltransferase inhibitors. Smadbeck J, Peterson MB, Zee BM, Garapaty S, Mago A, Lee C, Giannis A, Trojer P, Garcia BA, Floudas CA PloS one 24587223 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24587223
An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma'ayan A, Lemischka IR Frontiers in cell and developmental biology 33816475 Front Cell Dev Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33816475
ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression. Ratnakumar K, Duarte LF, LeRoy G, Hasson D, Smeets D, Vardabasso C, Bönisch C, Zeng T, Xiang B, Zhang DY, Li H, Wang X, Hake SB, Schermelleh L, Garcia BA, Bernstein E Genes & development 22391447 Genes Dev 2012 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/22391447
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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J Nature chemical biology 21743462 Nat Chem Biol 2011 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/21743462
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Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA MedChemComm 26257861 Medchemcomm 2015 May 1 https://www.ncbi.nlm.nih.gov/pubmed/26257861
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Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy. Taldone T, Gomes-DaGama EM, Zong H, Sen S, Alpaugh ML, Zatorska D, Alonso-Sabadell R, Guzman ML, Chiosis G Bioorganic & medicinal chemistry letters 21802945 Bioorg Med Chem Lett 2011 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/21802945
Multiscale photoacoustic microscopy of single-walled carbon nanotube-incorporated tissue engineering scaffolds. Cai X, Paratala BS, Hu S, Sitharaman B, Wang LV Tissue engineering. Part C, Methods 22082018 Tissue Eng Part C Methods 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22082018
Cell specific cytotoxicity and uptake of graphene nanoribbons. Mullick Chowdhury S, Lalwani G, Zhang K, Yang JY, Neville K, Sitharaman B Biomaterials 23072942 Biomaterials 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23072942
Physicochemical characterization, and relaxometry studies of micro-graphite oxide, graphene nanoplatelets, and nanoribbons. Paratala BS, Jacobson BD, Kanakia S, Francis LD, Sitharaman B PloS one 22685555 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22685555
Fabrication and cytocompatibility of in situ crosslinked carbon nanomaterial films. Patel SC, Lalwani G, Grover K, Qin YX, Sitharaman B Scientific reports 26018775 Sci Rep 2015 May 28 https://www.ncbi.nlm.nih.gov/pubmed/26018775
Nanofilm generated non-pharmacological anabolic bone stimulus. Talukdar Y, Rashkow JT, Patel S, Lalwani G, Bastidas J, Khan S, Sitharaman B Journal of biomedical materials research. Part A 31581364 J Biomed Mater Res A 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31581364
Enzymatic Degradation of Oxidized and Reduced Graphene Nanoribbons by Lignin Peroxidase. Lalwani G, Xing W, Sitharaman B Journal of materials chemistry. B 25215188 J Mater Chem B 2014 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/25215188
Structural disruption increases toxicity of graphene nanoribbons. Mullick Chowdhury S, Dasgupta S, McElroy AE, Sitharaman B Journal of applied toxicology : JAT 25224919 J Appl Toxicol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25224919
Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Chowdhury SM, Surhland C, Sanchez Z, Chaudhary P, Suresh Kumar MA, Lee S, Peña LA, Waring M, Sitharaman B, Naidu M Nanomedicine : nanotechnology, biology, and medicine 25131339 Nanomedicine 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25131339
Graphene-based contrast agents for photoacoustic and thermoacoustic tomography. Lalwani G, Cai X, Nie L, Wang LV, Sitharaman B Photoacoustics 24490141 Photoacoustics 2013 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/24490141
Porous three-dimensional carbon nanotube scaffolds for tissue engineering. Lalwani G, Gopalan A, D'Agati M, Sankaran JS, Judex S, Qin YX, Sitharaman B Journal of biomedical materials research. Part A 25788440 J Biomed Mater Res A 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25788440
Toxicology of graphene-based nanomaterials. Lalwani G, D'Agati M, Khan AM, Sitharaman B Advanced drug delivery reviews 27154267 Adv Drug Deliv Rev 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27154267
Three-dimensional carbon nanotube scaffolds for long-term maintenance and expansion of human mesenchymal stem cells. Lalwani G, D'agati M, Gopalan A, Patel SC, Talukdar Y, Sitharaman B Journal of biomedical materials research. Part A 28295953 J Biomed Mater Res A 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28295953
The magnetic, relaxometric, and optical properties of gadolinium-catalyzed single walled carbon nanotubes. Sitharaman B, Jacobson BD, Wadghiri YZ, Bryant H, Frank J Journal of applied physics 23653487 J Appl Phys 2013 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/23653487
Fabrication and Characterization of Three-Dimensional Macroscopic All-Carbon Scaffolds. Lalwani G, Kwaczala AT, Kanakia S, Patel SC, Judex S, Sitharaman B Carbon 23436939 Carbon N Y 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23436939
Delivery of long chain C(16) and C(24) ceramide in HeLa cells using oxidized graphene nanoribbons. Suhrland C, Truman JP, Obeid LM, Sitharaman B Journal of biomedical materials research. Part B, Applied biomaterials 31444959 J Biomed Mater Res B Appl Biomater 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/31444959
Quantification of single-cell nanoparticle concentrations and the distribution of these concentrations in cell population. Rashkow JT, Patel SC, Tappero R, Sitharaman B Journal of the Royal Society, Interface 24554576 J R Soc Interface 2014 May 6 https://www.ncbi.nlm.nih.gov/pubmed/24554576
Two-dimensional nanostructure-reinforced biodegradable polymeric nanocomposites for bone tissue engineering. Lalwani G, Henslee AM, Farshid B, Lin L, Kasper FK, Qin YX, Mikos AG, Sitharaman B Biomacromolecules 23405887 Biomacromolecules 2013 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/23405887
Graphene-based platforms for cancer therapeutics. Patel SC, Lee S, Lalwani G, Suhrland C, Chowdhury SM, Sitharaman B Therapeutic delivery 26769305 Ther Deliv 2016 https://www.ncbi.nlm.nih.gov/pubmed/26769305
Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. Mullick Chowdhury S, Manepalli P, Sitharaman B Acta biomaterialia 24980059 Acta Biomater 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24980059
Synthesis, Characterization, In Vitro Phantom Imaging, and Cytotoxicity of A Novel Graphene-Based Multimodal Magnetic Resonance Imaging - X-Ray Computed Tomography Contrast Agent. Lalwani G, Sundararaj JL, Schaefer K, Button T, Sitharaman B Journal of materials chemistry. B 24999431 J Mater Chem B 2014 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/24999431
Cytotoxicity, cytocompatibility, cell-labeling efficiency, and in vitro cellular magnetic resonance imaging of gadolinium-catalyzed single-walled carbon nanotubes. Avti PK, Caparelli ED, Sitharaman B Journal of biomedical materials research. Part A 23686792 J Biomed Mater Res A 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23686792
Interaction of graphene nanoribbons with components of the blood vascular system. Chowdhury SM, Fang J, Sitharaman B Future science OA 26925250 Future Sci OA 2015 https://www.ncbi.nlm.nih.gov/pubmed/26925250
Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells. Rashkow JT, Talukdar Y, Lalwani G, Sitharaman B Nanomedicine (London, England) 26080694 Nanomedicine (Lond) 2015 https://www.ncbi.nlm.nih.gov/pubmed/26080694
Boron nitride nanotubes and nanoplatelets as reinforcing agents of polymeric matrices for bone tissue engineering. Farshid B, Lalwani G, Shir Mohammadi M, Simonsen J, Sitharaman B Journal of biomedical materials research. Part B, Applied biomaterials 26526153 J Biomed Mater Res B Appl Biomater 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/26526153
In Vitro Bioactivity of One- and Two-Dimensional Nanoparticle-Incorporated Bone Tissue Engineering Scaffolds. Rashkow JT, Lalwani G, Sitharaman B Tissue engineering. Part A 28762866 Tissue Eng Part A 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/28762866
Multimodal ultrasound-photoacoustic imaging of tissue engineering scaffolds and blood oxygen saturation in and around the scaffolds. Talukdar Y, Avti P, Sun J, Sitharaman B Tissue engineering. Part C, Methods 24107069 Tissue Eng Part C Methods 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24107069
Tungsten disulfide nanotubes reinforced biodegradable polymers for bone tissue engineering. Lalwani G, Henslee AM, Farshid B, Parmar P, Lin L, Qin YX, Kasper FK, Mikos AG, Sitharaman B Acta biomaterialia 23727293 Acta Biomater 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23727293
Detection, mapping, and quantification of single walled carbon nanotubes in histological specimens with photoacoustic microscopy. Avti PK, Hu S, Favazza C, Mikos AG, Jansen JA, Shroyer KR, Wang LV, Sitharaman B PloS one 22496892 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22496892
The effects of graphene nanostructures on mesenchymal stem cells. Talukdar Y, Rashkow J, Lalwani G, Kanakia S, Sitharaman B Biomaterials 24674462 Biomaterials 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24674462
In vitro cytocompatibility of one-dimensional and two-dimensional nanostructure-reinforced biodegradable polymeric nanocomposites. Farshid B, Lalwani G, Sitharaman B Journal of biomedical materials research. Part A 25367032 J Biomed Mater Res A 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25367032
Vasoactive effects of stable aqueous suspensions of single walled carbon nanotubes in hamsters and mice. Frame MD, Dewar AM, Mullick Chowdhury S, Sitharaman B Nanotoxicology 23992463 Nanotoxicology 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/23992463
Toward single-walled carbon nanotube-gadolinium complex as advanced MRI contrast agents: pharmacodynamics and global genomic response in small animals. Avti PK, Talukdar Y, Sirotkin MV, Shroyer KR, Sitharaman B Journal of biomedical materials research. Part B, Applied biomaterials 23559429 J Biomed Mater Res B Appl Biomater 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23559429
A novel nanoparticle-enhanced photoacoustic stimulus for bone tissue engineering. Sitharaman B, Avti PK, Schaefer K, Talukdar Y, Longtin JP Tissue engineering. Part A 21395444 Tissue Eng Part A 2011 Jul https://www.ncbi.nlm.nih.gov/pubmed/21395444
Recycling microcavity optical biosensors. Hunt HK, Armani AM Optics letters 21478993 Opt Lett 2011 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/21478993
Monitoring DNA hybridization using optical microcavities. Hawk RM, Chistiakova MV, Armani AM Optics letters 24322107 Opt Lett 2013 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/24322107
Titanium-enhanced Raman microcavity laser. Deka N, Maker AJ, Armani AM Optics letters 24690786 Opt Lett 2014 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/24690786
Real-time detection of lipid bilayer assembly and detergent-initiated solubilization using optical cavities. Sun V, Armani AM Applied physics letters 25759510 Appl Phys Lett 2015 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/25759510
Label free detection of 5'hydroxymethylcytosine within CpG islands using optical sensors. Hawk RM, Armani AM Biosensors & bioelectronics 25461158 Biosens Bioelectron 2015 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/25461158
Nanowatt threshold, alumina sensitized neodymium laser integrated on silicon. Maker AJ, Armani AM Optics express 24216946 Opt Express 2013 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/24216946
Attaching biological probes to silica optical biosensors using silane coupling agents. Soteropulos CE, Hunt HK Journal of visualized experiments : JoVE 22588224 J Vis Exp 2012 May 1 https://www.ncbi.nlm.nih.gov/pubmed/22588224
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Temperature sensor based on a hybrid ITO-silica resonant cavity. Socorro AB, Soltani S, Del Villar I, Corres JM, Armani AM Optics express 25836065 Opt Express 2015 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/25836065
A compressive sensing approach for glioma margin delineation using mass spectrometry. Gholami B, Agar NY, Jolesz FA, Haddad WM, Tannenbaum AR Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22255629 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22255629
First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, Sengupta S Journal of biomedical nanotechnology 27319222 J Biomed Nanotechnol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27319222
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Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis. Calligaris D, Caragacianu D, Liu X, Norton I, Thompson CJ, Richardson AL, Golshan M, Easterling ML, Santagata S, Dillon DA, Jolesz FA, Agar NY Proceedings of the National Academy of Sciences of the United States of America 25246570 Proc Natl Acad Sci U S A 2014 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/25246570
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Santagata S, Eberlin LS, Norton I, Calligaris D, Feldman DR, Ide JL, Liu X, Wiley JS, Vestal ML, Ramkissoon SH, Orringer DA, Gill KK, Dunn IF, Dias-Santagata D, Ligon KL, Jolesz FA, Golby AJ, Cooks RG, Agar NY Proceedings of the National Academy of Sciences of the United States of America 24982150 Proc Natl Acad Sci U S A 2014 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/24982150
Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System. Parrish KE, Cen L, Murray J, Calligaris D, Kizilbash S, Mittapalli RK, Carlson BL, Schroeder MA, Sludden J, Boddy AV, Agar NY, Curtin NJ, Elmquist WF, Sarkaria JN Molecular cancer therapeutics 26438157 Mol Cancer Ther 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26438157
Classifying human brain tumors by lipid imaging with mass spectrometry. Eberlin LS, Norton I, Dill AL, Golby AJ, Ligon KL, Santagata S, Cooks RG, Agar NY Cancer research 22139378 Cancer Res 2012 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/22139378
Classification of astrocytomas and oligodendrogliomas from mass spectrometry data using sparse kernel machines. Huang J, Gholami B, Agar NY, Norton I, Haddad WM, Tannenbaum AR Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22256188 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22256188
Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG Proceedings of the National Academy of Sciences of the United States of America 23300285 Proc Natl Acad Sci U S A 2013 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/23300285
Recursive feature elimination for brain tumor classification using desorption electrospray ionization mass spectrometry imaging. Gholami B, Norton I, Tannenbaum AR, Agar NY Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 23367115 Annu Int Conf IEEE Eng Med Biol Soc 2012 https://www.ncbi.nlm.nih.gov/pubmed/23367115
Label-Free Neurosurgical Pathology with Stimulated Raman Imaging. Lu FK, Calligaris D, Olubiyi OI, Norton I, Yang W, Santagata S, Xie XS, Golby AJ, Agar NY Cancer research 27197198 Cancer Res 2016 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/27197198
Profiling of adrenocorticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC-ESI-MS-MS. Kertesz V, Calligaris D, Feldman DR, Changelian A, Laws ER, Santagata S, Agar NY, Van Berkel GJ Analytical and bioanalytical chemistry 26084546 Anal Bioanal Chem 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26084546
The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma. Pokorny JL, Calligaris D, Gupta SK, Iyekegbe DO Jr, Mueller D, Bakken KK, Carlson BL, Schroeder MA, Evans DL, Lou Z, Decker PA, Eckel-Passow JE, Pucci V, Ma B, Shumway SD, Elmquist WF, Agar NY, Sarkaria JN Clinical cancer research : an official journal of the American Association for Cancer Research 25609063 Clin Cancer Res 2015 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/25609063
Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY Scientific reports 24091529 Sci Rep 2013 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/24091529
Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS Science translational medicine 24005159 Sci Transl Med 2013 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/24005159
Reconstruction and Feature Selection for Desorption Electrospray Ionization Mass Spectroscopy Imagery. Gao Y, Zhu L, Norton I, Agar NY, Tannenbaum A Proceedings of SPIE--the International Society for Optical Engineering 25302009 Proc SPIE Int Soc Opt Eng 2014 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/25302009
A statistical modeling approach for tumor-type identification in surgical neuropathology using tissue mass spectrometry imaging. Gholami B, Norton I, Eberlin LS, Agar NY IEEE journal of biomedical and health informatics 24592474 IEEE J Biomed Health Inform 2013 May https://www.ncbi.nlm.nih.gov/pubmed/24592474
Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections. Eberlin LS, Liu X, Ferreira CR, Santagata S, Agar NY, Cooks RG Analytical chemistry 21975048 Anal Chem 2011 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/21975048
Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making. Calligaris D, Feldman DR, Norton I, Brastianos PK, Dunn IF, Santagata S, Agar NY International journal of mass spectrometry 25844057 Int J Mass Spectrom 2015 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/25844057
MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation. Calligaris D, Feldman DR, Norton I, Olubiyi O, Changelian AN, Machaidze R, Vestal ML, Laws ER, Dunn IF, Santagata S, Agar NY Proceedings of the National Academy of Sciences of the United States of America 26216958 Proc Natl Acad Sci U S A 2015 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/26216958
A review of bacteria-animal lateral gene transfer may inform our understanding of diseases like cancer. Robinson KM, Sieber KB, Dunning Hotopp JC PLoS genetics 24146634 PLoS Genet 2013 https://www.ncbi.nlm.nih.gov/pubmed/24146634
Horizontal gene transfer between bacteria and animals. Dunning Hotopp JC Trends in genetics : TIG 21334091 Trends Genet 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21334091
Targeted Enrichment and Sequencing of Recent Endosymbiont-Host Lateral Gene Transfers. Dunning Hotopp JC, Slatko BE, Foster JM Scientific reports 28405008 Sci Rep 2017 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/28405008
Lateral gene transfer between prokaryotes and eukaryotes. Sieber KB, Bromley RE, Dunning Hotopp JC Experimental cell research 28189637 Exp Cell Res 2017 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/28189637
Distinguishing potential bacteria-tumor associations from contamination in a secondary data analysis of public cancer genome sequence data. Robinson KM, Crabtree J, Mattick JS, Anderson KE, Dunning Hotopp JC Microbiome 28118849 Microbiome 2017 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/28118849
Single molecule sequencing and genome assembly of a clinical specimen of Loa loa, the causative agent of loiasis. Tallon LJ, Liu X, Bennuru S, Chibucos MC, Godinez A, Ott S, Zhao X, Sadzewicz L, Fraser CM, Nutman TB, Dunning Hotopp JC BMC genomics 25217238 BMC Genomics 2014 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/25217238
Extensive duplication of the Wolbachia DNA in chromosome four of Drosophila ananassae. Klasson L, Kumar N, Bromley R, Sieber K, Flowers M, Ott SH, Tallon LJ, Andersson SG, Dunning Hotopp JC BMC genomics 25496002 BMC Genomics 2014 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/25496002
Genomics of Loa loa, a Wolbachia-free filarial parasite of humans. Desjardins CA, Cerqueira GC, Goldberg JM, Dunning Hotopp JC, Haas BJ, Zucker J, Ribeiro JM, Saif S, Levin JZ, Fan L, Zeng Q, Russ C, Wortman JR, Fink DL, Birren BW, Nutman TB Nature genetics 23525074 Nat Genet 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23525074
Biology wars: the eukaryotes strike back. Dunning Hotopp JC, Estes AM Cell host & microbe 25498339 Cell Host Microbe 2014 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/25498339
Efficient Enrichment of Bacterial mRNA from Host-Bacteria Total RNA Samples. Kumar N, Lin M, Zhao X, Ott S, Santana-Cruz I, Daugherty S, Rikihisa Y, Sadzewicz L, Tallon LJ, Fraser CM, Dunning Hotopp JC Scientific reports 27713560 Sci Rep 2016 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/27713560
The genome of Onchocerca volvulus, agent of river blindness. Cotton JA, Bennuru S, Grote A, Harsha B, Tracey A, Beech R, Doyle SR, Dunn M, Hotopp JC, Holroyd N, Kikuchi T, Lambert O, Mhashilkar A, Mutowo P, Nursimulu N, Ribeiro JM, Rogers MB, Stanley E, Swapna LS, Tsai IJ, Unnasch TR, Voronin D, Parkinson J, Nutman TB, Ghedin E, Berriman M, Lustigman S Nature microbiology 27869790 Nat Microbiol 2016 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/27869790
Modeling the integration of bacterial rRNA fragments into the human cancer genome. Sieber KB, Gajer P, Dunning Hotopp JC BMC bioinformatics 27001685 BMC Bioinformatics 2016 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/27001685
Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen. Robinson KM, Dunning Hotopp JC Cancer letters 24956175 Cancer Lett 2014 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/24956175
Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. Riley DR, Sieber KB, Robinson KM, White JR, Ganesan A, Nourbakhsh S, Dunning Hotopp JC PLoS computational biology 23840181 PLoS Comput Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23840181
Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi. Ioannidis P, Johnston KL, Riley DR, Kumar N, White JR, Olarte KT, Ott S, Tallon LJ, Foster JM, Taylor MJ, Dunning Hotopp JC BMC genomics 24053607 BMC Genomics 2013 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/24053607
MIWI2 and MILI Have Differential Effects on piRNA Biogenesis and DNA Methylation. Manakov SA, Pezic D, Marinov GK, Pastor WA, Sachidanandam R, Aravin AA Cell reports 26279574 Cell Rep 2015 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/26279574
Small but sturdy: small RNAs in cellular memory and epigenetics. Stuwe E, Tóth KF, Aravin AA Genes & development 24589774 Genes Dev 2014 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24589774
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells. Pezic D, Manakov SA, Sachidanandam R, Aravin AA Genes & development 24939875 Genes Dev 2014 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/24939875
MORC1 represses transposable elements in the mouse male germline. Pastor WA, Stroud H, Nee K, Liu W, Pezic D, Manakov S, Lee SA, Moissiard G, Zamudio N, Bourc'his D, Aravin AA, Clark AT, Jacobsen SE Nature communications 25503965 Nat Commun 2014 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/25503965
Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors. Chen YA, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Toth KF, Aravin AA Molecular cell 27292797 Mol Cell 2016 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/27292797
Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA. Liu Y, Esyunina D, Olovnikov I, Teplova M, Kulbachinskiy A, Aravin AA, Patel DJ Cell reports 29996105 Cell Rep 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29996105
A transgenerational process defines piRNA biogenesis in Drosophila virilis. Le Thomas A, Marinov GK, Aravin AA Cell reports 25199836 Cell Rep 2014 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/25199836
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, Rogers AK, Webster A, Marinov GK, Liao SE, Perkins EM, Hur JK, Aravin AA, Tóth KF Genes & development 23392610 Genes Dev 2013 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/23392610
Small RNA in the nucleus: the RNA-chromatin ping-pong. Olovnikov I, Aravin AA, Fejes Toth K Current opinion in genetics & development 22349141 Curr Opin Genet Dev 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22349141
To be or not to be a piRNA: genomic origin and processing of piRNAs. Le Thomas A, Tóth KF, Aravin AA Genome biology 24467990 Genome Biol 2014 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/24467990
Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Le Thomas A, Stuwe E, Li S, Du J, Marinov G, Rozhkov N, Chen YC, Luo Y, Sachidanandam R, Toth KF, Patel D, Aravin AA Genes & development 25085419 Genes Dev 2014 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/25085419
A framework for piRNA cluster manipulation. Olovnikov I, Le Thomas A, Aravin AA Methods in molecular biology (Clifton, N.J.) 24178556 Methods Mol Biol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24178556
Production of artificial piRNAs in flies and mice. Muerdter F, Olovnikov I, Molaro A, Rozhkov NV, Czech B, Gordon A, Hannon GJ, Aravin AA RNA (New York, N.Y.) 22096018 RNA 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22096018
Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Hur JK, Luo Y, Moon S, Ninova M, Marinov GK, Chung YD, Aravin AA Genes & development 27036967 Genes Dev 2016 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/27036967
Bacterial argonaute samples the transcriptome to identify foreign DNA. Olovnikov I, Chan K, Sachidanandam R, Newman DK, Aravin AA Molecular cell 24034694 Mol Cell 2013 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/24034694
Non-Coding RNAs in Transcriptional Regulation: The review for Current Molecular Biology Reports. Chen YA, Aravin AA Current molecular biology reports 26120554 Curr Mol Biol Rep 2015 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26120554
Prokaryotic Argonautes defend genomes against invasive DNA. Hur JK, Olovnikov I, Aravin AA Trends in biochemical sciences 24836995 Trends Biochem Sci 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24836995
Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Webster A, Li S, Hur JK, Wachsmuth M, Bois JS, Perkins EM, Patel DJ, Aravin AA Molecular cell 26295961 Mol Cell 2015 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/26295961
Precision medicine for suicidality: from universality to subtypes and personalization. Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR Molecular psychiatry 28809398 Mol Psychiatry 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28809398
Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD, Bowker D, Gupta J, Bell R, Edenberg HJ, Tsuang MT, Kuczenski R, Geyer MA, Rodd ZA, Niculescu AB Translational psychiatry 22832392 Transl Psychiatry 2011 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/22832392
Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB Molecular psychiatry 27046645 Mol Psychiatry 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27046645
Discovery and validation of blood biomarkers for suicidality. Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB 3rd Molecular psychiatry 23958961 Mol Psychiatry 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23958961
Convergent functional genomics of psychiatric disorders. Niculescu AB American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 23728881 Am J Med Genet B Neuropsychiatr Genet 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23728881
Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Niculescu AB, Levey D, Le-Niculescu H, Niculescu E, Kurian SM, Salomon D Molecular psychiatry 25582618 Mol Psychiatry 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25582618
Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, Williams A, Bhairo S, Voegtline T, Davis H, Shekhar A, Kurian SM, Niculescu AB Molecular psychiatry 33828235 Mol Psychiatry 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33828235
Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs. Le-Niculescu H, Roseberry K, Levey DF, Rogers J, Kosary K, Prabha S, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Phalen PL, Mamdani F, Sequeira A, Kurian SM, Niculescu AB Molecular psychiatry 30862937 Mol Psychiatry 2020 May https://www.ncbi.nlm.nih.gov/pubmed/30862937
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Ayalew M, Le-Niculescu H, Levey DF, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon D, Schork NJ, Fanous AH, O'Donovan MC, Niculescu AB Molecular psychiatry 22584867 Mol Psychiatry 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22584867
Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR Molecular psychiatry 26283638 Mol Psychiatry 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26283638
Dissecting Suicidality Using a Combined Genomic and Clinical Approach. Niculescu AB, Le-Niculescu H Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 27909331 Neuropsychopharmacology 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27909331
A brief proposal for improving clinical trials. Niculescu AB Molecular psychiatry 27021813 Mol Psychiatry 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27021813
Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs. Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A, Robertson H, Jones T, Strasburger A, Williams A, Kurian SM, Lamb B, Shekhar A, Lahiri DK, Saykin AJ Molecular psychiatry 31792364 Mol Psychiatry 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/31792364
Genetic risk prediction and neurobiological understanding of alcoholism. Levey DF, Le-Niculescu H, Frank J, Ayalew M, Jain N, Kirlin B, Learman R, Winiger E, Rodd Z, Shekhar A, Schork N, Kiefer F, Wodarz N, Müller-Myhsok B, Dahmen N, GESGA Consortium, Nöthen M, Sherva R, Farrer L, Smith AH, Kranzler HR, Rietschel M, Gelernter J, Niculescu AB Translational psychiatry 24844177 Transl Psychiatry 2014 May 20 https://www.ncbi.nlm.nih.gov/pubmed/24844177
Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M, Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA, Niculescu AB Translational psychiatry 22832404 Transl Psychiatry 2011 May 24 https://www.ncbi.nlm.nih.gov/pubmed/22832404
Convergent functional genomics of stem cell-derived cells. Niculescu AB Translational psychiatry 24022510 Transl Psychiatry 2013 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/24022510
Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. Niculescu AB, Le-Niculescu H, Levey DF, Roseberry K, Soe KC, Rogers J, Khan F, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Kurian SM, White FA Molecular psychiatry 30755720 Mol Psychiatry 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30755720
A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Tsuneki M, Hardee S, Michaud M, Morotti R, Lavik E, Madri JA Laboratory investigation; a journal of technical methods and pathology 25961170 Lab Invest 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25961170
Materials design at the interface of nanoparticles and innate immunity. Szeto GL, Lavik EB Journal of materials chemistry. B 27453783 J Mater Chem B 2016 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/27453783
Intravenously administered nanoparticles increase survival following blast trauma. Lashof-Sullivan MM, Shoffstall E, Atkins KT, Keane N, Bir C, VandeVord P, Lavik EB Proceedings of the National Academy of Sciences of the United States of America 24982180 Proc Natl Acad Sci U S A 2014 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/24982180
Controlled release of photoswitch drugs by degradable polymer microspheres. Groynom R, Shoffstall E, Wu LS, Kramer RH, Lavik EB Journal of drug targeting 26453166 J Drug Target 2015 https://www.ncbi.nlm.nih.gov/pubmed/26453166
Novel drug delivery systems for glaucoma. Lavik E, Kuehn MH, Kwon YH Eye (London, England) 21475311 Eye (Lond) 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21475311
The role of nanomaterials in translational medicine. Lavik E, von Recum H ACS nano 21604811 ACS Nano 2011 May 24 https://www.ncbi.nlm.nih.gov/pubmed/21604811
Steroid-Loaded Hemostatic Nanoparticles Combat Lung Injury after Blast Trauma. Hubbard WB, Lashof-Sullivan MM, Lavik EB, VandeVord PJ ACS macro letters 27668129 ACS Macro Lett 2015 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/27668129
Intravenous hemostatic nanoparticles increase survival following blunt trauma injury. Shoffstall AJ, Atkins KT, Groynom RE, Varley ME, Everhart LM, Lashof-Sullivan MM, Martyn-Dow B, Butler RS, Ustin JS, Lavik EB Biomacromolecules 22998772 Biomacromolecules 2012 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/22998772
Intravenous hemostats: challenges in translation to patients. Lashof-Sullivan M, Shoffstall A, Lavik E Nanoscale 24088870 Nanoscale 2013 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/24088870
Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma. Onwukwe C, Maisha N, Holland M, Varley M, Groynom R, Hickman D, Uppal N, Shoffstall A, Ustin J, Lavik E Bioconjugate chemistry 29965731 Bioconjug Chem 2018 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/29965731
Short term interactions with long term consequences: modulation of chimeric vessels by neural progenitors. Williams C, Rauch MF, Michaud M, Robinson R, Xu H, Madri J, Lavik E PloS one 23300890 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/23300890
Sustained Delivery of Timolol Maleate for Over 90 Days by Subconjunctival Injection. Lavik E, Kuehn MH, Shoffstall AJ, Atkins K, Dumitrescu AV, Kwon YH Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 27835065 J Ocul Pharmacol Ther 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27835065
Olfactory ensheathing cells promote differentiation of neural stem cells and robust neurite extension. Sethi R, Sethi R, Redmond A, Lavik E Stem cell reviews and reports 24996386 Stem Cell Rev Rep 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/24996386
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In Vivo Targeting of Metabolically Labeled Cancers with Ultra-Small Silica Nanoconjugates. Wang H, Tang L, Liu Y, Dobrucka IT, Dobrucki LW, Yin L, Cheng J Theranostics 27375793 Theranostics 2016 https://www.ncbi.nlm.nih.gov/pubmed/27375793
Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis. Yin Q, Tang L, Cai K, Tong R, Sternberg R, Yang X, Dobrucki LW, Borst LB, Kamstock D, Song Z, Helferich WG, Cheng J, Fan TM Proceedings of the National Academy of Sciences of the United States of America 27457945 Proc Natl Acad Sci U S A 2016 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/27457945
Dynamic urea bond for the design of reversible and self-healing polymers. Ying H, Zhang Y, Cheng J Nature communications 24492620 Nat Commun 2014 https://www.ncbi.nlm.nih.gov/pubmed/24492620
Helical antimicrobial polypeptides with radial amphiphilicity. Xiong M, Lee MW, Mansbach RA, Song Z, Bao Y, Peek RM Jr, Yao C, Chen LF, Ferguson AL, Wong GC, Cheng J Proceedings of the National Academy of Sciences of the United States of America 26460016 Proc Natl Acad Sci U S A 2015 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/26460016
The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides. Zhang R, Zheng N, Song Z, Yin L, Cheng J Biomaterials 24439403 Biomaterials 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24439403
Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates. Tang L, Gabrielson NP, Uckun FM, Fan TM, Cheng J Molecular pharmaceutics 23301497 Mol Pharm 2013 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/23301497
Synthesis of water-soluble poly(α-hydroxy acids) from living ring-opening polymerization of O-benzyl-L-serine carboxyanhydrides. Lu Y, Yin L, Zhang Y, Zhonghai Z, Xu Y, Tong R, Cheng J ACS macro letters 23359651 ACS Macro Lett 2012 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/23359651
Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates. Tang L, Fan TM, Borst LB, Cheng J ACS nano 22494403 ACS Nano 2012 May 22 https://www.ncbi.nlm.nih.gov/pubmed/22494403
Water-soluble poly(L-serine)s with elongated and charged side-chains: synthesis, conformations, and cell-penetrating properties. Tang H, Yin L, Lu H, Cheng J Biomacromolecules 22853191 Biomacromolecules 2012 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/22853191
A cell-penetrating helical polymer for siRNA delivery to mammalian cells. Gabrielson NP, Lu H, Yin L, Kim KH, Cheng J Molecular therapy : the journal of the American Society of Gene Therapy 22643866 Mol Ther 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22643866
Targeted Ultrasound-Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging using Click Chemistry. Wang H, Gauthier M, Kelly JR, Miller RJ, Xu M, O'Brien WD Jr, Cheng J Angewandte Chemie (International ed. in English) 27010510 Angew Chem Int Ed Engl 2016 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/27010510
Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker. Yin Q, Tong R, Yin L, Fan TM, Cheng J Polymer chemistry 26005498 Polym Chem 2014 https://www.ncbi.nlm.nih.gov/pubmed/26005498
Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release. Lee JS, Deng X, Han P, Cheng J Macromolecular bioscience 26036966 Macromol Biosci 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26036966
Non-invasive, real-time reporting drug release in vitro and in vivo. Zhang Y, Yin Q, Yen J, Li J, Ying H, Wang H, Hua Y, Chaney EJ, Boppart SA, Cheng J Chemical communications (Cambridge, England) 25798457 Chem Commun (Camb) 2015 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/25798457
Hydrolyzable polyureas bearing hindered urea bonds. Ying H, Cheng J Journal of the American Chemical Society 25406025 J Am Chem Soc 2014 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/25406025
CD22ΔE12 as a molecular target for RNAi therapy. Uckun FM, Ma H, Cheng J, Myers DE, Qazi S British journal of haematology 25659406 Br J Haematol 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25659406
Investigating the optimal size of anticancer nanomedicine. Tang L, Yang X, Yin Q, Cai K, Wang H, Chaudhury I, Yao C, Zhou Q, Kwon M, Hartman JA, Dobrucki IT, Dobrucki LW, Borst LB, Lezmi S, Helferich WG, Ferguson AL, Fan TM, Cheng J Proceedings of the National Academy of Sciences of the United States of America 25316794 Proc Natl Acad Sci U S A 2014 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/25316794
Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery. Gabrielson NP, Lu H, Yin L, Li D, Wang F, Cheng J Angewandte Chemie (International ed. in English) 22162307 Angew Chem Int Ed Engl 2012 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/22162307
Synthesis of hybrid block copolymers via integrated ring-opening metathesis polymerization and polymerization of NCA. Bai Y, Lu H, Ponnusamy E, Cheng J Chemical communications (Cambridge, England) 21869956 Chem Commun (Camb) 2011 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/21869956
Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity. Deng X, Zheng N, Song Z, Yin L, Cheng J Biomaterials 24674461 Biomaterials 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24674461
Redox-Responsive, Core Cross-Linked Polyester Micelles. Zhang Z, Yin L, Tu C, Song Z, Zhang Y, Xu Y, Tong R, Zhou Q, Ren J, Cheng J ACS macro letters 23536920 ACS Macro Lett 2013 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/23536920
In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction. Wang H, Bo Y, Liu Y, Xu M, Cai K, Wang R, Cheng J Biomaterials 31323538 Biomaterials 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31323538
Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery. Zheng N, Song Z, Yang J, Liu Y, Li F, Cheng J, Yin L Acta biomaterialia 28476586 Acta Biomater 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28476586
Ionic α-helical polypeptides toward nonviral gene delivery. Zhang R, Song Z, Yin L, Zheng N, Tang H, Lu H, Gabrielson NP, Lin Y, Kim K, Cheng J Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 25377262 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2015 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/25377262
Bioorthogonal Oxime Ligation Mediated In Vivo Cancer Targeting. Tang L, Yin Q, Xu Y, Zhou Q, Cai K, Yen J, Dobrucki LW, Cheng J Chemical science 26146536 Chem Sci 2015 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/26146536
Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics. Cai K, Yen J, Yin Q, Liu Y, Song Z, Lezmi S, Zhang Y, Yang X, Helferich WG, Cheng J Biomaterials science 26146551 Biomater Sci 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26146551
Enhanced Non-Viral Gene Delivery to Human Embryonic Stem Cells via Small Molecule-Mediated Transient Alteration of Cell Structure. Yen J, Yin L, Cheng J Journal of materials chemistry. B 26005572 J Mater Chem B 2014 https://www.ncbi.nlm.nih.gov/pubmed/26005572
Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates. Yin Q, Tong R, Xu Y, Baek K, Dobrucki LW, Fan TM, Cheng J Biomacromolecules 23445497 Biomacromolecules 2013 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/23445497
Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo. Xing H, Tang L, Yang X, Hwang K, Wang W, Yin Q, Wong NY, Dobrucki LW, Yasui N, Katzenellenbogen JA, Helferich WG, Cheng J, Lu Y Journal of materials chemistry. B 24159374 J Mater Chem B 2013 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/24159374
Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging. Yin Q, Yap FY, Yin L, Ma L, Zhou Q, Dobrucki LW, Fan TM, Gaba RC, Cheng J Journal of the American Chemical Society 23987119 J Am Chem Soc 2013 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/23987119
Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A. Tang L, Azzi J, Kwon M, Mounayar M, Tong R, Yin Q, Moore R, Skartsis N, Fan TM, Abdi R, Cheng J Journal of transplantation 22545201 J Transplant 2012 https://www.ncbi.nlm.nih.gov/pubmed/22545201
Selective in vivo metabolic cell-labeling-mediated cancer targeting. Wang H, Wang R, Cai K, He H, Liu Y, Yen J, Wang Z, Xu M, Sun Y, Zhou X, Yin Q, Tang L, Dobrucki IT, Dobrucki LW, Chaney EJ, Boppart SA, Fan TM, Lezmi S, Chen X, Yin L, Cheng J Nature chemical biology 28192414 Nat Chem Biol 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28192414
Drug-Initiated, Controlled Ring-Opening Polymerization for the Synthesis of Polymer-Drug Conjugates. Tong R, Cheng J Macromolecules 23357880 Macromolecules 2012 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/23357880
Non-viral gene delivery via membrane-penetrating, mannose-targeting supramolecular self-assembled nanocomplexes. Yin L, Song Z, Kim KH, Zheng N, Gabrielson NP, Cheng J Advanced materials (Deerfield Beach, Fla.) 23417835 Adv Mater 2013 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/23417835
Facile functionalization of polyesters through thiol-yne chemistry for the design of degradable, cell-penetrating and gene delivery dual-functional agents. Zhang Z, Yin L, Xu Y, Tong R, Lu Y, Ren J, Cheng J Biomacromolecules 23098261 Biomacromolecules 2012 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/23098261
Chain-shattering polymeric therapeutics with on-demand drug-release capability. Zhang Y, Yin Q, Yin L, Ma L, Tang L, Cheng J Angewandte Chemie (International ed. in English) 23650111 Angew Chem Int Ed Engl 2013 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/23650111
Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice. Uckun FM, Myers DE, Cheng J, Qazi S EBioMedicine 26285772 EBioMedicine 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/26285772
Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery. Yin L, Song Z, Kim KH, Zheng N, Tang H, Lu H, Gabrielson N, Cheng J Biomaterials 23283350 Biomaterials 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23283350
Ionic polypeptides with unusual helical stability. Lu H, Wang J, Bai Y, Lang JW, Liu S, Lin Y, Cheng J Nature communications 21343924 Nat Commun 2011 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/21343924
Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation. Yin L, Song Z, Qu Q, Kim KH, Zheng N, Yao C, Chaudhury I, Tang H, Gabrielson NP, Uckun FM, Cheng J Angewandte Chemie (International ed. in English) 23610013 Angew Chem Int Ed Engl 2013 May 27 https://www.ncbi.nlm.nih.gov/pubmed/23610013
Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles. Cely I, Yiv S, Yin Q, Shahidzadeh A, Tang L, Cheng J, Uckun FM Journal of analytical oncology 23730399 J Anal Oncol 2012 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/23730399
Polymeric Nanomedicines Based on Poly(lactide) and Poly(lactide-co-glycolide). Tong R, Gabrielson NP, Fan TM, Cheng J Current opinion in solid state & materials science 23914135 Curr Opin Solid State Mater Sci 2012 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/23914135
Light-responsive helical polypeptides capable of reducing toxicity and unpacking DNA: toward nonviral gene delivery. Yin L, Tang H, Kim KH, Zheng N, Song Z, Gabrielson NP, Lu H, Cheng J Angewandte Chemie (International ed. in English) 23832670 Angew Chem Int Ed Engl 2013 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/23832670
Polyvalent mesoporous silica nanoparticle-aptamer bioconjugates target breast cancer cells. Li LL, Yin Q, Cheng J, Lu Y Advanced healthcare materials 23184791 Adv Healthc Mater 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/23184791
Maximizing gene delivery efficiencies of cationic helical polypeptides via balanced membrane penetration and cellular targeting. Zheng N, Yin L, Song Z, Ma L, Tang H, Gabrielson NP, Lu H, Cheng J Biomaterials 24211080 Biomaterials 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24211080
Mechanisms for Benzene Dissociation through the Excited State of T4 Lysozyme L99A Mutant. Feher VA, Schiffer JM, Mermelstein DJ, Mih N, Pierce LCT, McCammon JA, Amaro RE Biophysical journal 30606449 Biophys J 2019 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/30606449
The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release. Bohl HO, Ieong P, Lee JK, Lee T, Kankanala J, Shi K, Demir Ö, Kurahashi K, Amaro RE, Wang Z, Aihara H The Journal of biological chemistry 29626094 J Biol Chem 2018 May 25 https://www.ncbi.nlm.nih.gov/pubmed/29626094
Capturing Invisible Motions in the Transition from Ground to Rare Excited States of T4 Lysozyme L99A. Schiffer JM, Feher VA, Malmstrom RD, Sida R, Amaro RE Biophysical journal 27760351 Biophys J 2016 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/27760351
Progress towards automated Kepler scientific workflows for computer-aided drug discovery and molecular simulations. Ieong PU, Sørensen J, Vemu PL, Wong CW, Demir Ö, Williams NP, Wang J, Crawl D, Swift RV, Malmstrom RD, Altintas I, Amaro RE Procedia computer science 29399238 Procedia Comput Sci 2014 https://www.ncbi.nlm.nih.gov/pubmed/29399238
Two Relations to Estimate Membrane Permeability Using Milestoning. Votapka LW, Lee CT, Amaro RE The journal of physical chemistry. B 27154639 J Phys Chem B 2016 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/27154639
Emerging Computational Methods for the Rational Discovery of Allosteric Drugs. Wagner JR, Lee CT, Durrant JD, Malmstrom RD, Feher VA, Amaro RE Chemical reviews 27074285 Chem Rev 2016 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/27074285
The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches. Richards C, Albin JS, Demir Ö, Shaban NM, Luengas EM, Land AM, Anderson BD, Holten JR, Anderson JS, Harki DA, Amaro RE, Harris RS Cell reports 26628363 Cell Rep 2015 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/26628363
Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis. Van Wart AT, Durrant J, Votapka L, Amaro RE Journal of chemical theory and computation 24803851 J Chem Theory Comput 2014 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/24803851
Dynamics and Molecular Mechanisms of p53 Transcriptional Activation. Offutt TL, Ieong PU, Demir Ö, Amaro RE Biochemistry 30388364 Biochemistry 2018 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/30388364
Determinants of Oligonucleotide Selectivity of APOBEC3B. Wagner JR, Demir Ö, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE Journal of chemical information and modeling 30130104 J Chem Inf Model 2019 May 28 https://www.ncbi.nlm.nih.gov/pubmed/30130104
Quantitative Ranking of Ligand Binding Kinetics with a Multiscale Milestoning Simulation Approach. Jagger BR, Lee CT, Amaro RE The journal of physical chemistry letters 30070844 J Phys Chem Lett 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/30070844
Elements of nucleotide specificity in the Trypanosoma brucei mitochondrial RNA editing enzyme RET2. Demir Ö, Amaro RE Journal of chemical information and modeling 22512810 J Chem Inf Model 2012 May 25 https://www.ncbi.nlm.nih.gov/pubmed/22512810
Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases. Prabhu L, Chen L, Wei H, Demir Ö, Safa A, Zeng L, Amaro RE, O'Neil BH, Zhang ZY, Lu T Molecular bioSystems 29099132 Mol Biosyst 2017 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/29099132
Efficient Calculation of Accurate Reaction Energies-Assessment of Different Models in Electronic Structure Theory. Friedrich J Journal of chemical theory and computation 26574443 J Chem Theory Comput 2015 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/26574443
Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer. Schiffer JM, Malmstrom RD, Parnell J, Ramirez-Sarmiento C, Reyes J, Amaro RE, Komives EA Structure (London, England : 1993) 27396830 Structure 2016 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/27396830
WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets. Durrant JD, Amaro RE BMC bioinformatics 24886360 BMC Bioinformatics 2014 May 23 https://www.ncbi.nlm.nih.gov/pubmed/24886360
Magnesium-induced nucleophile activation in the guanylyltransferase mRNA capping enzyme. Swift RV, Ong CD, Amaro RE Biochemistry 23205906 Biochemistry 2012 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/23205906
Multiscale Methods in Drug Design Bridge Chemical and Biological Complexity in the Search for Cures. Amaro RE, Mulholland AJ Nature reviews. Chemistry 30949587 Nat Rev Chem 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/30949587
Designing novel inhibitors of Trypanosoma brucei. Demir O, Amaro RE Methods in molecular biology (Clifton, N.J.) 23568474 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23568474
Modeling the pharmacodynamics of passive membrane permeability. Swift RV, Amaro RE Journal of computer-aided molecular design 22042376 J Comput Aided Mol Des 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/22042376
Mechanism of 150-cavity formation in influenza neuraminidase. Amaro RE, Swift RV, Votapka L, Li WW, Walker RC, Bush RM Nature communications 21750542 Nat Commun 2011 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/21750542
Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants. Demir Ö, Baronio R, Salehi F, Wassman CD, Hall L, Hatfield GW, Chamberlin R, Kaiser P, Lathrop RH, Amaro RE PLoS computational biology 22028641 PLoS Comput Biol 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/22028641
Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53. Wassman CD, Baronio R, Demir Ö, Wallentine BD, Chen CK, Hall LV, Salehi F, Lin DW, Chung BP, Hatfield GW, Richard Chamberlin A, Luecke H, Lathrop RH, Kaiser P, Amaro RE Nature communications 23360998 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23360998
Computational chemistry and drug discovery: a call to action. Jansen JM, Amaro RE, Cornell W, Tseng YJ, Walters WP Future medicinal chemistry 23088271 Future Med Chem 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/23088271
Exploring residue component contributions to dynamical network models of allostery. Vanwart AT, Eargle J, Luthey-Schulten Z, Amaro RE Journal of chemical theory and computation 23139645 J Chem Theory Comput 2012 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/23139645
Knowledge-Based Methods To Train and Optimize Virtual Screening Ensembles. Swift RV, Jusoh SA, Offutt TL, Li ES, Amaro RE Journal of chemical information and modeling 27097522 J Chem Inf Model 2016 May 23 https://www.ncbi.nlm.nih.gov/pubmed/27097522
LipidWrapper: an algorithm for generating large-scale membrane models of arbitrary geometry. Durrant JD, Amaro RE PLoS computational biology 25032790 PLoS Comput Biol 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/25032790
A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases. Zimmermann S, Hall L, Riley S, Sørensen J, Amaro RE, Schnaufer A Nucleic acids research 26400159 Nucleic Acids Res 2016 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/26400159
Computational approaches to mapping allosteric pathways. Feher VA, Durrant JD, Van Wart AT, Amaro RE Current opinion in structural biology 24667124 Curr Opin Struct Biol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24667124
Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE Biochemistry 28221775 Biochemistry 2017 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/28221775
Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Shi K, Demir Ö, Carpenter MA, Wagner J, Kurahashi K, Harris RS, Amaro RE, Aihara H Scientific reports 29234087 Sci Rep 2017 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/29234087
Molecular Simulations Reveal an Unresolved Conformation of the Type IA Protein Kinase A Regulatory Subunit and Suggest Its Role in the cAMP Regulatory Mechanism. Hirakis SP, Malmstrom RD, Amaro RE Biochemistry 28661131 Biochemistry 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28661131
Structural basis for ligand modulation of the CCR2 conformational landscape. Taylor BC, Lee CT, Amaro RE Proceedings of the National Academy of Sciences of the United States of America 30975755 Proc Natl Acad Sci U S A 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/30975755
A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target. Amaro RE, Ieong PU, Huber G, Dommer A, Steven AC, Bush RM, Durrant JD, Votapka LW ACS central science 30555910 ACS Cent Sci 2018 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/30555910
Multiscale Estimation of Binding Kinetics Using Brownian Dynamics, Molecular Dynamics and Milestoning. Votapka LW, Amaro RE PLoS computational biology 26505480 PLoS Comput Biol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26505480
A Kepler Workflow Tool for Reproducible AMBER GPU Molecular Dynamics. Purawat S, Ieong PU, Malmstrom RD, Chan GJ, Yeung AK, Walker RC, Altintas I, Amaro RE Biophysical journal 28636905 Biophys J 2017 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/28636905
Diversity of immunoglobulin lambda light chain gene usage over developmental stages in the horse. Tallmadge RL, Tseng CT, Felippe MJ Developmental and comparative immunology 24726757 Dev Comp Immunol 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24726757
Effects of autologous stromal cells and cytokines on differentiation of equine bone marrow-derived progenitor cells. Schwab UE, Tallmadge RL, Matychak MB, Felippe MJB American journal of veterinary research 28945121 Am J Vet Res 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28945121
The Horse with Recurrent Fevers and Infections: Approach to Common Variable Immunodeficiency. Mullen KR, Felippe MJB The Veterinary clinics of North America. Equine practice 38789347 Vet Clin North Am Equine Pract 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38789347
Developmental expression of B cell molecules in equine lymphoid tissues. Prieto JMB, Tallmadge RL, Felippe MJB Veterinary immunology and immunopathology 28063478 Vet Immunol Immunopathol 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/28063478
Expression of essential B cell development genes in horses with common variable immunodeficiency. Tallmadge RL, Such KA, Miller KC, Matychak MB, Felippe MJ Molecular immunology 22464097 Mol Immunol 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22464097
Developmental progression of equine immunoglobulin heavy chain variable region diversity. Tallmadge RL, Tseng CT, King RA, Felippe MJ Developmental and comparative immunology 23567345 Dev Comp Immunol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23567345
Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation. Tallmadge RL, Shen L, Tseng CT, Miller SC, Barry J, Felippe MJ Clinical immunology (Orlando, Fla.) 25988861 Clin Immunol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25988861
Hematopoiesis in the equine fetal liver suggests immune preparedness. Battista JM, Tallmadge RL, Stokol T, Felippe MJ Immunogenetics 25179685 Immunogenetics 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25179685
Equine common variable immunodeficiency: lessons from 100 clinical cases. Julia M, Felippe B Equine veterinary education 39555145 Equine Vet Educ 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39555145
Microfluidic diagnostics for the developing world. Mao X, Huang TJ Lab on a chip 22406768 Lab Chip 2012 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/22406768
Surface acoustic wave microfluidics. Ding X, Li P, Lin SC, Stratton ZS, Nama N, Guo F, Slotcavage D, Mao X, Shi J, Costanzo F, Huang TJ Lab on a chip 23900527 Lab Chip 2013 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/23900527
Probing cell-cell communication with microfluidic devices. Guo F, French JB, Li P, Zhao H, Chan CY, Fick JR, Benkovic SJ, Huang TJ Lab on a chip 23843092 Lab Chip 2013 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/23843092
Multifunctional porous silicon nanopillar arrays: antireflection, superhydrophobicity, photoluminescence, and surface-enhanced Raman scattering. Kiraly B, Yang S, Huang TJ Nanotechnology 23703091 Nanotechnology 2013 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/23703091
Accelerating drug discovery via organs-on-chips. Chan CY, Huang PH, Guo F, Ding X, Kapur V, Mai JD, Yuen PK, Huang TJ Lab on a chip 24193241 Lab Chip 2013 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/24193241
A droplet-based, optofluidic device for high-throughput, quantitative bioanalysis. Guo F, Lapsley MI, Nawaz AA, Zhao Y, Lin SC, Chen Y, Yang S, Zhao XZ, Huang TJ Analytical chemistry 23140515 Anal Chem 2012 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/23140515
Microfluidic synthesis of multifunctional Janus particles for biomedical applications. Yang S, Guo F, Kiraly B, Mao X, Lu M, Leong KW, Huang TJ Lab on a chip 22584998 Lab Chip 2012 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/22584998
Three-dimensional hydrodynamic focusing method for polyplex synthesis. Lu M, Ho YP, Grigsby CL, Nawaz AA, Leong KW, Huang TJ ACS nano 24341632 ACS Nano 2014 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/24341632
Continuous enrichment of low-abundance cell samples using standing surface acoustic waves (SSAW). Chen Y, Li S, Gu Y, Li P, Ding X, Wang L, McCoy JP, Levine SJ, Huang TJ Lab on a chip 24413889 Lab Chip 2014 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/24413889
Shape-controlled synthesis of hybrid nanomaterials via three-dimensional hydrodynamic focusing. Lu M, Yang S, Ho YP, Grigsby CL, Leong KW, Huang TJ ACS nano 25268035 ACS Nano 2014 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/25268035
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Surface-Enhanced Raman Scattering Study on Graphene-Coated Metallic Nanostructure Substrates. Hao Q, Wang B, Bossard JA, Kiraly B, Zeng Y, Chiang IK, Jensen L, Werner DH, Huang TJ The journal of physical chemistry. C, Nanomaterials and interfaces 24772200 J Phys Chem C Nanomater Interfaces 2012 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/24772200
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Coordinated regulation of acid resistance in Escherichia coli. Aquino P, Honda B, Jaini S, Lyubetskaya A, Hosur K, Chiu JG, Ekladious I, Hu D, Jin L, Sayeg MK, Stettner AI, Wang J, Wong BG, Wong WS, Alexander SL, Ba C, Bensussen SI, Bernstein DB, Braff D, Cha S, Cheng DI, Cho JH, Chou K, Chuang J, Gastler DE, Grasso DJ, Greifenberger JS, Guo C, Hawes AK, Israni DV, Jain SR, Kim J, Lei J, Li H, Li D, Li Q, Mancuso CP, Mao N, Masud SF, Meisel CL, Mi J, Nykyforchyn CS, Park M, Peterson HM, Ramirez AK, Reynolds DS, Rim NG, Saffie JC, Su H, Su WR, Su Y, Sun M, Thommes MM, Tu T, Varongchayakul N, Wagner TE, Weinberg BH, Yang R, Yaroslavsky A, Yoon C, Zhao Y, Zollinger AJ, Stringer AM, Foster JW, Wade J, Raman S, Broude N, Wong WW, Galagan JE BMC systems biology 28061857 BMC Syst Biol 2017 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/28061857
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Determining the Specificity of Cascade Binding, Interference, and Primed Adaptation In Vivo in the Escherichia coli Type I-E CRISPR-Cas System. Cooper LA, Stringer AM, Wade JT mBio 29666291 mBio 2018 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/29666291
Genome-Wide Mapping of the Escherichia coli PhoB Regulon Reveals Many Transcriptionally Inert, Intragenic Binding Sites. Fitzgerald DM, Stringer AM, Smith C, Lapierre P, Wade JT mBio 37067422 mBio 2023 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/37067422
Genome-scale analyses of Escherichia coli and Salmonella enterica AraC reveal noncanonical targets and an expanded core regulon. Stringer AM, Currenti S, Bonocora RP, Baranowski C, Petrone BL, Palumbo MJ, Reilly AA, Zhang Z, Erill I, Wade JT Journal of bacteriology 24272778 J Bacteriol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24272778
FRUIT, a scar-free system for targeted chromosomal mutagenesis, epitope tagging, and promoter replacement in Escherichia coli and Salmonella enterica. Stringer AM, Singh N, Yermakova A, Petrone BL, Amarasinghe JJ, Reyes-Diaz L, Mantis NJ, Wade JT PloS one 23028641 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/23028641
Identification of novel sRNAs in mycobacterial species. Tsai CH, Baranowski C, Livny J, McDonough KA, Wade JT, Contreras LM PloS one 24244498 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24244498
Non-canonical protein-DNA interactions identified by ChIP are not artifacts. Bonocora RP, Fitzgerald DM, Stringer AM, Wade JT BMC genomics 23586855 BMC Genomics 2013 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/23586855
Genome-Scale Mapping of Escherichia coli σ54 Reveals Widespread, Conserved Intragenic Binding. Bonocora RP, Smith C, Lapierre P, Wade JT PLoS genetics 26425847 PLoS Genet 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26425847
SuhB Associates with Nus Factors To Facilitate 30S Ribosome Biogenesis in Escherichia coli. Singh N, Bubunenko M, Smith C, Abbott DM, Stringer AM, Shi R, Court DL, Wade JT mBio 26980831 mBio 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26980831
Pervasive transcription: illuminating the dark matter of bacterial transcriptomes. Wade JT, Grainger DC Nature reviews. Microbiology 25069631 Nat Rev Microbiol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25069631
MrpJ Directly Regulates Proteus mirabilis Virulence Factors, Including Fimbriae and Type VI Secretion, during Urinary Tract Infection. Debnath I, Stringer AM, Smith SN, Bae E, Mobley HLT, Wade JT, Pearson MM Infection and immunity 30082479 Infect Immun 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30082479
Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping. Adams PP, Baniulyte G, Esnault C, Chegireddy K, Singh N, Monge M, Dale RK, Storz G, Wade JT eLife 33460557 Elife 2021 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/33460557
The BvgAS Regulon of Bordetella pertussis. Moon K, Bonocora RP, Kim DD, Chen Q, Wade JT, Stibitz S, Hinton DM mBio 29018122 mBio 2017 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/29018122
Maestro of regulation: Riboswitches orchestrate gene expression at the levels of translation, transcription and mRNA decay. Bastet L, Turcotte P, Wade JT, Lafontaine DA RNA biology 29537923 RNA Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29537923
Chemical Inhibition of Kynureninase Reduces Pseudomonas aeruginosa Quorum Sensing and Virulence Factor Expression. Kasper SH, Bonocora RP, Wade JT, Musah RA, Cady NC ACS chemical biology 26785289 ACS Chem Biol 2016 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/26785289
ChIP-seq for genome-scale analysis of bacterial DNA-binding proteins. Bonocora RP, Wade JT Methods in molecular biology (Clifton, N.J.) 25665574 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25665574
Identification of regulatory targets for the bacterial Nus factor complex. Baniulyte G, Singh N, Benoit C, Johnson R, Ferguson R, Paramo M, Stringer AM, Scott A, Lapierre P, Wade JT Nature communications 29229908 Nat Commun 2017 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/29229908
Translational control and Rho-dependent transcription termination are intimately linked in riboswitch regulation. Bastet L, Chauvier A, Singh N, Lussier A, Lamontagne AM, Prévost K, Massé E, Wade JT, Lafontaine DA Nucleic acids research 28520932 Nucleic Acids Res 2017 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/28520932
Identification of HilD-regulated genes in Salmonella enterica serovar Typhimurium. Petrone BL, Stringer AM, Wade JT Journal of bacteriology 24375101 J Bacteriol 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24375101
Mapping the Regulatory Network for Salmonella enterica Serovar Typhimurium Invasion. Smith C, Stringer AM, Mao C, Palumbo MJ, Wade JT mBio 27601571 mBio 2016 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/27601571
A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics. Baniulyte G, Wade JT eLife 40439554 Elife 2025 May 29 https://www.ncbi.nlm.nih.gov/pubmed/40439554
Identification and characterization of small RNAs in Yersinia pestis. Beauregard A, Smith EA, Petrone BL, Singh N, Karch C, McDonough KA, Wade JT RNA biology 23324607 RNA Biol 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23324607
Genome-Wide Transcriptional Response to Varying RpoS Levels in Escherichia coli K-12. Wong GT, Bonocora RP, Schep AN, Beeler SM, Lee Fong AJ, Shull LM, Batachari LE, Dillon M, Evans C, Becker CJ, Bush EC, Hardin J, Wade JT, Stoebel DM Journal of bacteriology 28115545 J Bacteriol 2017 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/28115545
The evolutionary impact of intragenic FliA promoters in proteobacteria. Fitzgerald DM, Smith C, Lapierre P, Wade JT Molecular microbiology 29476659 Mol Microbiol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29476659
Identification of bacterial sRNA regulatory targets using ribosome profiling. Wang J, Rennie W, Liu C, Carmack CS, Prévost K, Caron MP, Massé E, Ding Y, Wade JT Nucleic acids research 26546513 Nucleic Acids Res 2015 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/26546513
Genome-wide mapping of the Escherichia coli PhoB regulon reveals many transcriptionally inert, intragenic binding sites. Fitzgerald D, Stringer A, Smith C, Lapierre P, Wade JT bioRxiv : the preprint server for biology 36798257 bioRxiv 2023 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/36798257
Mapping the Escherichia coli DnaA-binding landscape reveals a preference for binding pairs of closely spaced DNA sites. Stringer AM, Fitzgerald DM, Wade JT Microbiology (Reading, England) 39012340 Microbiology (Reading) 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/39012340
Biosensor diagnosis of urinary tract infections: a path to better treatment? Mach KE, Wong PK, Liao JC Trends in pharmacological sciences 21458868 Trends Pharmacol Sci 2011 Jun https://www.ncbi.nlm.nih.gov/pubmed/21458868
Cellular self-organization by autocatalytic alignment feedback. Junkin M, Leung SL, Whitman S, Gregorio CC, Wong PK Journal of cell science 22193956 J Cell Sci 2011 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/22193956
Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1. Chu M, Novak SM, Cover C, Wang AA, Chinyere IR, Juneman EB, Zarnescu DC, Wong PK, Gregorio CC Circulation 29101288 Circulation 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29101288
Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration. Riahi R, Sun J, Wang S, Long M, Zhang DD, Wong PK Nature communications 25766473 Nat Commun 2015 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/25766473
Electrokinetic focusing and separation of mammalian cells in conductive biological fluids. Gao J, Riahi R, Sin ML, Zhang S, Wong PK The Analyst 22937529 Analyst 2012 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/22937529
Advances in techniques for probing mechanoregulation of tissue morphogenesis. Sun J, Xiao Y, Wang S, Slepian MJ, Wong PK Journal of laboratory automation 25331491 J Lab Autom 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25331491
Mapping photothermally induced gene expression in living cells and tissues by nanorod-locked nucleic acid complexes. Riahi R, Wang S, Long M, Li N, Chiou PY, Zhang DD, Wong PK ACS nano 24645754 ACS Nano 2014 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/24645754
A nanobiosensor for dynamic single cell analysis during microvascular self-organization. Wang S, Sun J, Zhang DD, Wong PK Nanoscale 27547924 Nanoscale 2016 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/27547924
Geometric control of capillary architecture via cell-matrix mechanical interactions. Sun J, Jamilpour N, Wang FY, Wong PK Biomaterials 24439400 Biomaterials 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24439400
Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading. Lu Y, Gao J, Zhang DD, Gau V, Liao JC, Wong PK Analytical chemistry 23445209 Anal Chem 2013 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/23445209
A Microfiltration Device for Urogenital Schistosomiasis Diagnostics. Xiao Y, Lu Y, Hsieh M, Liao J, Wong PK PloS one 27124499 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27124499
Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling. Wang S, Sun J, Xiao Y, Lu Y, Zhang DD, Wong PK Advanced biosystems 30662935 Adv Biosyst 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/30662935
Probing cell migration in confined environments by plasma lithography. Junkin M, Wong PK Biomaterials 21134692 Biomaterials 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21134692
Electrokinetic stringency control in self-assembled monolayer-based biosensors for multiplex urinary tract infection diagnosis. Liu T, Sin ML, Pyne JD, Gau V, Liao JC, Wong PK Nanomedicine : nanotechnology, biology, and medicine 23891989 Nanomedicine 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23891989
In situ electrokinetic enhancement for self-assembled-monolayer-based electrochemical biosensing. Sin ML, Liu T, Pyne JD, Gau V, Liao JC, Wong PK Analytical chemistry 22397486 Anal Chem 2012 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/22397486
Calcium wave propagation in networks of endothelial cells: model-based theoretical and experimental study. Long J, Junkin M, Wong PK, Hoying J, Deymier P PLoS computational biology 23300426 PLoS Comput Biol 2012 https://www.ncbi.nlm.nih.gov/pubmed/23300426
A Universal Electrode Approach for Automated Electrochemical Molecular Analyses. Sin ML, Gau V, Liao JC, Wong PK Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems 24860248 J Microelectromech Syst 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/24860248
Plasma lithography surface patterning for creation of cell networks. Junkin M, Leung SL, Yang Y, Lu Y, Volmering J, Wong PK Journal of visualized experiments : JoVE 21694697 J Vis Exp 2011 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/21694697
A microfluidic model for organ-specific extravasation of circulating tumor cells. Riahi R, Yang YL, Kim H, Jiang L, Wong PK, Zohar Y Biomicrofluidics 24803959 Biomicrofluidics 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24803959
A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells. Wang S, Xiao Y, Zhang DD, Wong PK Biomaterials 29190498 Biomaterials 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29190498
Collective Cell Migration in 3D Epithelial Wound Healing. Xiao Y, Riahi R, Torab P, Zhang DD, Wong PK ACS nano 30758172 ACS Nano 2019 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/30758172
Molecular detection of bacterial pathogens using microparticle enhanced double-stranded DNA probes. Riahi R, Mach KE, Mohan R, Liao JC, Wong PK Analytical chemistry 21718053 Anal Chem 2011 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/21718053
Hybrid electrokinetic manipulation in high-conductivity media. Gao J, Sin ML, Liu T, Gau V, Liao JC, Wong PK Lab on a chip 21487576 Lab Chip 2011 May 21 https://www.ncbi.nlm.nih.gov/pubmed/21487576
Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates. Nam KH, Jamilpour N, Mfoumou E, Wang FY, Zhang DD, Wong PK Scientific reports 25376886 Sci Rep 2014 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/25376886
Spatiotemporal dynamics of microRNA during epithelial collective cell migration. Dean ZS, Riahi R, Wong PK Biomaterials 25453946 Biomaterials 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25453946
Single cell nanobiosensors for dynamic gene expression profiling in native tissue microenvironments. Wang S, Riahi R, Li N, Zhang DD, Wong PK Advanced materials (Deerfield Beach, Fla.) 26314800 Adv Mater 2015 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/26314800
Long-range electrothermal fluid motion in microfluidic systems. Lu Y, Ren Q, Liu T, Leung SL, Gau V, Liao JC, Chan CL, Wong PK International journal of heat and mass transfer 27127306 Int J Heat Mass Transf 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27127306
Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility. Sun J, Hoying JB, Deymier PA, Zhang DD, Wong PK PLoS computational biology 27196735 PLoS Comput Biol 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27196735
Single cell gene expression analysis in injury-induced collective cell migration. Riahi R, Long M, Yang Y, Dean Z, Zhang DD, Slepian MJ, Wong PK Integrative biology : quantitative biosciences from nano to macro 24336811 Integr Biol (Camb) 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24336811
Intelligent Systems and Technology for Integrative and Predictive Medicine: An ACP Approach. Wang FY, Wong PK ACM transactions on intelligent systems and technology 24883228 ACM Trans Intell Syst Technol 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24883228
Detection of mRNA in living cells by double-stranded locked nucleic acid probes. Riahi R, Dean Z, Wu TH, Teitell MA, Chiou PY, Zhang DD, Wong PK The Analyst 23772441 Analyst 2013 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/23772441
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC Proceedings of the National Academy of Sciences of the United States of America 26487682 Proc Natl Acad Sci U S A 2015 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/26487682
An AC electrokinetics facilitated biosensor cassette for rapid pathogen identification. Ouyang M, Mohan R, Lu Y, Liu T, Mach KE, Sin ML, McComb M, Joshi J, Gau V, Wong PK, Liao JC The Analyst 23626988 Analyst 2013 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/23626988
Mechanically induced intercellular calcium communication in confined endothelial structures. Junkin M, Lu Y, Long J, Deymier PA, Hoying JB, Wong PK Biomaterials 23267827 Biomaterials 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23267827
Advances in wound-healing assays for probing collective cell migration. Riahi R, Yang Y, Zhang DD, Wong PK Journal of laboratory automation 22357609 J Lab Autom 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22357609
Statistical metamodeling for revealing synergistic antimicrobial interactions. Chen HC, Gau V, Zhang DD, Liao JC, Wang FY, Wong PK PloS one 21124958 PLoS One 2010 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/21124958
Rapid antimicrobial susceptibility testing with electrokinetics enhanced biosensors for diagnosis of acute bacterial infections. Liu T, Lu Y, Gau V, Liao JC, Wong PK Annals of biomedical engineering 24889716 Ann Biomed Eng 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/24889716
Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement. Yang Y, Jamilpour N, Yao B, Dean ZS, Riahi R, Wong PK Scientific reports 26936382 Sci Rep 2016 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/26936382
A UAV-Mounted Whole Cell Biosensor System for Environmental Monitoring Applications. Lu Y, Macias D, Dean ZS, Kreger NR, Wong PK IEEE transactions on nanobioscience 26584498 IEEE Trans Nanobioscience 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26584498
Oncogenic KRAS confers chemoresistance by upregulating NRF2. Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD Cancer research 25339352 Cancer Res 2014 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/25339352
AC Electrokinetics of Physiological Fluids for Biomedical Applications. Lu Y, Liu T, Lamanda AC, Sin ML, Gau V, Liao JC, Wong PK Journal of laboratory automation 25487557 J Lab Autom 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/25487557
Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes. Duan F, Curtis KL, March JC Applied and environmental microbiology 18836005 Appl Environ Microbiol 2008 Dec https://www.ncbi.nlm.nih.gov/pubmed/18836005
Synthetic small intestinal scaffolds for improved studies of intestinal differentiation. Costello CM, Hongpeng J, Shaffiey S, Yu J, Jain NK, Hackam D, March JC Biotechnology and bioengineering 24390638 Biotechnol Bioeng 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24390638
A universal DNA-based protein detection system. Tran TN, Cui J, Hartman MR, Peng S, Funabashi H, Duan F, Yang D, March JC, Lis JT, Cui H, Luo D Journal of the American Chemical Society 23978265 J Am Chem Soc 2013 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/23978265
Salmonella enterica Serovar Typhimurium Increases Functional PD-L1 Synergistically with Gamma Interferon in Intestinal Epithelial Cells via Salmonella Pathogenicity Island 2. Sahler JM, Eade CR, Altier C, March JC Infection and immunity 29440366 Infect Immun 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29440366
Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes. Duan FF, Liu JH, March JC Diabetes.. 25626737 Diabetes 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25626737
Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals. Shaffiey SA, Jia H, Keane T, Costello C, Wasserman D, Quidgley M, Dziki J, Badylak S, Sodhi CP, March JC, Hackam DJ Regenerative medicine 26395928 Regen Med 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26395928
3-D intestinal scaffolds for evaluating the therapeutic potential of probiotics. Costello CM, Sorna RM, Goh YL, Cengic I, Jain NK, March JC Molecular pharmaceutics 24798584 Mol Pharm 2014 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/24798584
Engineering commensal bacteria for prophylaxis against infection. Goh YL, He H, March JC Current opinion in biotechnology 22459613 Curr Opin Biotechnol 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/22459613
Generation of an artificial intestine for the management of short bowel syndrome. Ladd MR, Niño DF, March JC, Sodhi CP, Hackam DJ Current opinion in organ transplantation 26867049 Curr Opin Organ Transplant 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26867049
FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L, Major MB Science signaling 22949735 Sci Signal 2012 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/22949735
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization. Orvis T, Hepperla A, Walter V, Song S, Simon J, Parker J, Wilkerson MD, Desai N, Major MB, Hayes DN, Davis IJ, Weissman B Cancer research 25115300 Cancer Res 2014 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/25115300
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB Cancer research 24322982 Cancer Res 2014 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/24322982
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB Cancer research 23382044 Cancer Res 2013 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/23382044
SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development. Wei D, Goldfarb D, Song S, Cannon C, Yan F, Sakellariou-Thompson D, Emanuele M, Major MB, Weissman BE, Kuwahara Y Molecular cancer research : MCR 25009291 Mol Cancer Res 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25009291
FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Walker MP, Stopford CM, Cederlund M, Fang F, Jahn C, Rabinowitz AD, Goldfarb D, Graham DM, Yan F, Deal AM, Fedoriw Y, Richards KL, Davis IJ, Weidinger G, Damania B, Major MB Science signaling 25650440 Sci Signal 2015 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/25650440
Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1. Giffin L, Yan F, Ben Major M, Damania B Journal of virology 24920810 J Virol 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24920810
The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase. Onyenwoke RU, Sexton JZ, Yan F, Díaz MC, Forsberg LJ, Major MB, Brenman JE The Biochemical journal 26195823 Biochem J 2015 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/26195823
Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB Molecular and cellular biology 25332235 Mol Cell Biol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25332235
Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening. Shah PK, Walker MP, Sims CE, Major MB, Allbritton NL Integrative biology : quantitative biosciences from nano to macro 24871928 Integr Biol (Camb) 2014 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/24871928
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, Virshup DM, Chou MM, Major MB Proceedings of the National Academy of Sciences of the United States of America 27162353 Proc Natl Acad Sci U S A 2016 May 24 https://www.ncbi.nlm.nih.gov/pubmed/27162353
An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum. Nasamu AS, Falla A, Pasaje CFA, Wall BA, Wagner JC, Ganesan SM, Goldfless SJ, Niles JC Scientific reports 33431920 Sci Rep 2021 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/33431920
Quantification of labile heme in live malaria parasites using a genetically encoded biosensor. Abshire JR, Rowlands CJ, Ganesan SM, So PT, Niles JC Proceedings of the National Academy of Sciences of the United States of America 28242687 Proc Natl Acad Sci U S A 2017 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/28242687
An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum. Wagner JC, Goldfless SJ, Ganesan SM, Lee MC, Fidock DA, Niles JC Malaria journal 24160265 Malar J 2013 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/24160265
Synthetic RNA-protein modules integrated with native translation mechanisms to control gene expression in malaria parasites. Ganesan SM, Falla A, Goldfless SJ, Nasamu AS, Niles JC Nature communications 26925876 Nat Commun 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26925876
Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite. Dankwa S, Lim C, Bei AK, Jiang RH, Abshire JR, Patel SD, Goldberg JM, Moreno Y, Kono M, Niles JC, Duraisingh MT Nature communications 27041489 Nat Commun 2016 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/27041489
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum. Wagner JC, Platt RJ, Goldfless SJ, Zhang F, Niles JC Nature methods 25108687 Nat Methods 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25108687
Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE eLife 30888318 Elife 2019 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/30888318
Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens. Amberg-Johnson K, Hari SB, Ganesan SM, Lorenzi HA, Sauer RT, Niles JC, Yeh E eLife 28826494 Elife 2017 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/28826494
Identification of malaria parasite-infected red blood cell surface aptamers by inertial microfluidic SELEX (I-SELEX). Birch CM, Hou HW, Han J, Niles JC Scientific reports 26126714 Sci Rep 2015 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/26126714
Direct and specific chemical control of eukaryotic translation with a synthetic RNA-protein interaction. Goldfless SJ, Belmont BJ, de Paz AM, Liu JF, Niles JC Nucleic acids research 22275521 Nucleic Acids Res 2012 May https://www.ncbi.nlm.nih.gov/pubmed/22275521
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JPJ, Carruthers VB, Niles JC, Lourido S Cell 27594426 Cell 2016 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/27594426
Inducible control of subcellular RNA localization using a synthetic protein-RNA aptamer interaction. Belmont BJ, Niles JC PloS one 23056498 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/23056498
ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites. Walczak M, Ganesan SM, Niles JC, Yeh E mBio 29295911 mBio 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29295911
Versatile control of Plasmodium falciparum gene expression with an inducible protein-RNA interaction. Goldfless SJ, Wagner JC, Niles JC Nature communications 25370483 Nat Commun 2014 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/25370483
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Wilson SR, Thé L, Batia LM, Beattie K, Katibah GE, McClain SP, Pellegrino M, Estandian DM, Bautista DM Cell 24094650 Cell 2013 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/24094650
The ion channel TRPA1 is required for chronic itch. Wilson SR, Nelson AM, Batia L, Morita T, Estandian D, Owens DM, Lumpkin EA, Bautista DM The Journal of neuroscience : the official journal of the Society for Neuroscience 23719797 J Neurosci 2013 May 29 https://www.ncbi.nlm.nih.gov/pubmed/23719797
TRPA1: A gatekeeper for inflammation. Bautista DM, Pellegrino M, Tsunozaki M Annual review of physiology 23020579 Annu Rev Physiol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23020579
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, Bautista DM Nature neuroscience 21460831 Nat Neurosci 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21460831
The star-nosed mole reveals clues to the molecular basis of mammalian touch. Gerhold KA, Pellegrino M, Tsunozaki M, Morita T, Leitch DB, Tsuruda PR, Brem RB, Catania KC, Bautista DM PloS one 23383028 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/23383028
Mammalian touch catches up. Walsh CM, Bautista DM, Lumpkin EA Current opinion in neurobiology 26100741 Curr Opin Neurobiol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26100741
Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Tseng P, Judy JW, Di Carlo D Nature methods 23064517 Nat Methods 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/23064517
Advances in high-throughput single-cell microtechnologies. Weaver WM, Tseng P, Kunze A, Masaeli M, Chung AJ, Dudani JS, Kittur H, Kulkarni RP, Di Carlo D Current opinion in biotechnology 24484889 Curr Opin Biotechnol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24484889
The Age of Cortical Neural Networks Affects Their Interactions with Magnetic Nanoparticles. Tay A, Kunze A, Jun D, Hoek E, Di Carlo D Small (Weinheim an der Bergstrasse, Germany) 27228954 Small 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27228954
Metallization and biopatterning on ultra-flexible substrates via dextran sacrificial layers. Tseng P, Pushkarsky I, Di Carlo D PloS one 25153326 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25153326
Modulating motility of intracellular vesicles in cortical neurons with nanomagnetic forces on-chip. Kunze A, Murray CT, Godzich C, Lin J, Owsley K, Tay A, Di Carlo D Lab on a chip 28164203 Lab Chip 2017 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/28164203
Quantitative Magnetic Separation of Particles and Cells Using Gradient Magnetic Ratcheting. Murray C, Pao E, Tseng P, Aftab S, Kulkarni R, Rettig M, Di Carlo D Small (Weinheim an der Bergstrasse, Germany) 26890496 Small 2016 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/26890496
Induction of Calcium Influx in Cortical Neural Networks by Nanomagnetic Forces. Tay A, Kunze A, Murray C, Di Carlo D ACS nano 26805612 ACS Nano 2016 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/26805612
Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner. Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA Jr British journal of pharmacology 27352269 Br J Pharmacol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27352269
Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Griffin DR, Weaver WM, Scumpia PO, Di Carlo D, Segura T Nature materials 26030305 Nat Mater 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26030305
Elastomeric sensor surfaces for high-throughput single-cell force cytometry. Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF Jr, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA Jr, Damoiseaux R, Di Carlo D Nature biomedical engineering 31015629 Nat Biomed Eng 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/31015629
Publisher Correction: Elastomeric sensor surfaces for high-throughput single-cell force cytometry. Pushkarsky I, Tseng P, Black D, France B, Warfe L, Koziol-White CJ, Jester WF Jr, Trinh RK, Lin J, Scumpia PO, Morrison SL, Panettieri RA Jr, Damoiseaux R, Di Carlo D Nature biomedical engineering 31015734 Nat Biomed Eng 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/31015734
Substrates with patterned extracellular matrix and subcellular stiffness gradients reveal local biomechanical responses. Tseng P, Di Carlo D Advanced materials (Deerfield Beach, Fla.) 24323894 Adv Mater 2014 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/24323894
Engineering cortical neuron polarity with nanomagnets on a chip. Kunze A, Tseng P, Godzich C, Murray C, Caputo A, Schweizer FE, Di Carlo D ACS nano 25801533 ACS Nano 2015 https://www.ncbi.nlm.nih.gov/pubmed/25801533
High-Throughput Microfluidic Sorting of Live Magnetotactic Bacteria. Tay A, Pfeiffer D, Rowe K, Tannenbaum A, Popp F, Strangeway R, Schüler D, Di Carlo D Applied and environmental microbiology 29959254 Appl Environ Microbiol 2018 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/29959254
Probing Cell Adhesion Profiles with a Microscale Adhesive Choice Assay. Kittur H, Tay A, Hua A, Yu M, Di Carlo D Biophysical journal 29045879 Biophys J 2017 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/29045879
Flexible and stretchable micromagnet arrays for tunable biointerfacing. Tseng P, Lin J, Owsley K, Kong J, Kunze A, Murray C, Di Carlo D Advanced materials (Deerfield Beach, Fla.) 25537971 Adv Mater 2015 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/25537971
Mapping Sub-Second Structure in Mouse Behavior. Wiltschko AB, Johnson MJ, Iurilli G, Peterson RE, Katon JM, Pashkovski SL, Abraira VE, Adams RP, Datta SR Neuron 26687221 Neuron 2015 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/26687221
A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. Greer PL, Bear DM, Lassance JM, Bloom ML, Tsukahara T, Pashkovski SL, Masuda FK, Nowlan AC, Kirchner R, Hoekstra HE, Datta SR Cell 27238024 Cell 2016 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/27238024
Optical highlighter molecules in neurobiology. Datta SR, Patterson GH Current opinion in neurobiology 22129781 Curr Opin Neurobiol 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22129781
Detection and avoidance of a carnivore odor by prey. Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD Proceedings of the National Academy of Sciences of the United States of America 21690383 Proc Natl Acad Sci U S A 2011 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/21690383
Distinct representations of olfactory information in different cortical centres. Sosulski DL, Bloom ML, Cutforth T, Axel R, Datta SR Nature 21451525 Nature 2011 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/21451525
Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry. Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA Developmental neurobiology 24913191 Dev Neurobiol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/24913191
Olfactory maps, circuits and computations. Giessel AJ, Datta SR Current opinion in neurobiology 24492088 Curr Opin Neurobiol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24492088
Click-assembled, oxygen-sensing nanoconjugates for depth-resolved, near-infrared imaging in a 3D cancer model. Nichols AJ, Roussakis E, Klein OJ, Evans CL Angewandte Chemie (International ed. in English) 24590700 Angew Chem Int Ed Engl 2014 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/24590700
An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy. Klein OJ, Yuan H, Nowell NH, Kaittanis C, Josephson L, Evans CL Scientific reports 29042620 Sci Rep 2017 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/29042620
Bright, "Clickable" Porphyrins for the Visualization of Oxygenation under Ambient Light. Roussakis E, Li Z, Nowell NH, Nichols AJ, Evans CL Angewandte Chemie (International ed. in English) 26510549 Angew Chem Int Ed Engl 2015 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/26510549
Promotion of Proapoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy. Kessel D, Evans CL Photochemistry and photobiology 27096545 Photochem Photobiol 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27096545
Longitudinal, quantitative monitoring of therapeutic response in 3D in vitro tumor models with OCT for high-content therapeutic screening. Klein OJ, Jung YK, Evans CL Methods (San Diego, Calif.) 24013042 Methods 2014 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/24013042
In vitro optimization of EtNBS-PDT against hypoxic tumor environments with a tiered, high-content, 3D model optical screening platform. Klein OJ, Bhayana B, Park YJ, Evans CL Molecular pharmaceutics 22946843 Mol Pharm 2012 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/22946843
Longitudinal, label-free, quantitative tracking of cell death and viability in a 3D tumor model with OCT. Jung Y, Klein OJ, Wang H, Evans CL Scientific reports 27248849 Sci Rep 2016 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/27248849
Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage. Li Z, Roussakis E, Koolen PG, Ibrahim AM, Kim K, Rose LF, Wu J, Nichols AJ, Baek Y, Birngruber R, Apiou-Sbirlea G, Matyal R, Huang T, Chan R, Lin SJ, Evans CL Biomedical optics express 25426308 Biomed Opt Express 2014 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/25426308
Killing hypoxic cell populations in a 3D tumor model with EtNBS-PDT. Evans CL, Abu-Yousif AO, Park YJ, Klein OJ, Celli JP, Rizvi I, Zheng X, Hasan T PloS one 21876751 PLoS One 2011 https://www.ncbi.nlm.nih.gov/pubmed/21876751
Longitudinal, 3D in vivo imaging of sebaceous glands by coherent anti-stokes Raman scattering microscopy: normal function and response to cryotherapy. Jung Y, Tam J, Ray Jalian H, Rox Anderson R, Evans CL The Journal of investigative dermatology 25026458 J Invest Dermatol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25026458
Structure-function relationships of Nile blue (EtNBS) derivatives as antimicrobial photosensitizers. Vecchio D, Bhayana B, Huang L, Carrasco E, Evans CL, Hamblin MR European journal of medicinal chemistry 24561676 Eur J Med Chem 2014 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/24561676
Video-rate scanning confocal microscopy and microendoscopy. Nichols AJ, Evans CL Journal of visualized experiments : JoVE 22042305 J Vis Exp 2011 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/22042305
Label-Free, Longitudinal Visualization of PDT Response In Vitro with Optical Coherence Tomography. Jung Y, Nichols AJ, Klein OJ, Roussakis E, Evans CL Israel journal of chemistry 23316088 Isr J Chem 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/23316088
PLGA nanoparticle encapsulation reduces toxicity while retaining the therapeutic efficacy of EtNBS-PDT in vitro. Hung HI, Klein OJ, Peterson SW, Rokosh SR, Osseiran S, Nowell NH, Evans CL Scientific reports 27686626 Sci Rep 2016 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/27686626
Comprehensive evaluation of peripheral nerve regeneration in the acute healing phase using tissue clearing and optical microscopy in a rodent model. Jung Y, Ng JH, Keating CP, Senthil-Kumar P, Zhao J, Randolph MA, Winograd JM, Evans CL PloS one 24714405 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24714405
3D-resolved targeting of photodynamic therapy using temporal focusing. Rowlands CJ, Wu J, Uzel SG, Klein O, Evans CL, So PT Laser physics letters 25620902 Laser Phys Lett 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25620902
Strain tunes proteolytic degradation and diffusive transport in fibrin networks. Adhikari AS, Mekhdjian AH, Dunn AR Biomacromolecules 22185486 Biomacromolecules 2012 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/22185486
Spatial distribution of cell-cell and cell-ECM adhesions regulates force balance while main-taining E-cadherin molecular tension in cell pairs. Sim JY, Moeller J, Hart KC, Ramallo D, Vogel V, Dunn AR, Nelson WJ, Pruitt BL Molecular biology of the cell 25971797 Mol Biol Cell 2015 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/25971797
The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination. Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G Developmental cell 25203208 Dev Cell 2014 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/25203208
Quantification of nanowire penetration into living cells. Xu AM, Aalipour A, Leal-Ortiz S, Mekhdjian AH, Xie X, Dunn AR, Garner CC, Melosh NA Nature communications 24710350 Nat Commun 2014 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/24710350
A force balance can explain local and global cell movements during early zebrafish development. Chai J, Hamilton AL, Krieg M, Buckley CD, Riedel-Kruse IH, Dunn AR Biophysical journal 26200877 Biophys J 2015 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/26200877
E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Borghi N, Sorokina M, Shcherbakova OG, Weis WI, Pruitt BL, Nelson WJ, Dunn AR Proceedings of the National Academy of Sciences of the United States of America 22802638 Proc Natl Acad Sci U S A 2012 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/22802638
Molecular tension sensors report forces generated by single integrin molecules in living cells. Morimatsu M, Mekhdjian AH, Adhikari AS, Dunn AR Nano letters 23859772 Nano Lett 2013 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/23859772
Mechanical systems biology of C. elegans touch sensation. Krieg M, Dunn AR, Goodman MB BioEssays : news and reviews in molecular, cellular and developmental biology 25597279 Bioessays 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25597279
Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1. Adhikari AS, Chai J, Dunn AR Journal of the American Chemical Society 21247159 J Am Chem Soc 2011 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/21247159
Single Molecule Force Measurements in Living Cells Reveal a Minimally Tensioned Integrin State. Chang AC, Mekhdjian AH, Morimatsu M, Denisin AK, Pruitt BL, Dunn AR ACS nano 27779848 ACS Nano 2016 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/27779848
Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. Surya VN, Michalaki E, Huang EY, Fuller GG, Dunn AR Journal of the Royal Society, Interface 27974574 J R Soc Interface 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27974574
How Hydra Eats. Dunn AR Biophysical journal 27074672 Biophys J 2016 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/27074672
Visualizing the interior architecture of focal adhesions with high-resolution traction maps. Morimatsu M, Mekhdjian AH, Chang AC, Tan SJ, Dunn AR Nano letters 25730141 Nano Lett 2015 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/25730141
Multiplexed Fluid Flow Device to Study Cellular Response to Tunable Shear Stress Gradients. Ostrowski MA, Huang EY, Surya VN, Poplawski C, Barakat JM, Lin GL, Fuller GG, Dunn AR Annals of biomedical engineering 26589597 Ann Biomed Eng 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/26589597
Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases. Adhikari AS, Glassey E, Dunn AR Journal of the American Chemical Society 22720833 J Am Chem Soc 2012 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/22720833
Multiplexed single-molecule force proteolysis measurements using magnetic tweezers. Adhikari AS, Chai J, Dunn AR Journal of visualized experiments : JoVE 22871786 J Vis Exp 2012 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/22871786
Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force. Buckley CD, Tan J, Anderson KL, Hanein D, Volkmann N, Weis WI, Nelson WJ, Dunn AR Science (New York, N.Y.) 25359979 Science 2014 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/25359979
Mechanical control of the sense of touch by β-spectrin. Krieg M, Dunn AR, Goodman MB Nature cell biology 24561618 Nat Cell Biol 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24561618
Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow. Ostrowski MA, Huang NF, Walker TW, Verwijlen T, Poplawski C, Khoo AS, Cooke JP, Fuller GG, Dunn AR Biophysical journal 24461011 Biophys J 2014 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/24461011
HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection. Tang Z, Su KH, Xu M, Dai C Science advances 33177089 Sci Adv 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33177089
Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK. Dai S, Tang Z, Cao J, Zhou W, Li H, Sampson S, Dai C The EMBO journal 25425574 EMBO J 2015 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/25425574
HSF1: Guardian of Proteostasis in Cancer. Dai C, Sampson SB Trends in cell biology 26597576 Trends Cell Biol 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26597576
Iron addiction: a novel therapeutic target in ovarian cancer. Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV Oncogene 28319068 Oncogene 2017 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/28319068
Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response. Xu M, Lin L, Ram BM, Shriwas O, Chuang KH, Dai S, Su KH, Tang Z, Dai C Cell reports 37224019 Cell Rep 2023 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/37224019
Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders. Su KH, Dai C Cellular and molecular life sciences : CMLS 27289378 Cell Mol Life Sci 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27289378
Visualization of RAS/MAPK Signaling In Situ by the Proximity Ligation Assay (PLA). Tang Z, Dai C Methods in molecular biology (Clifton, N.J.) 27924568 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/27924568
MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1. Tang Z, Dai S, He Y, Doty RA, Shultz LD, Sampson SB, Dai C Cell 25679764 Cell 2015 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/25679764
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Stem cells and modeling of autism spectrum disorders. Freitas BC, Trujillo CA, Carromeu C, Yusupova M, Herai RH, Muotri AR Experimental neurology 23036599 Exp Neurol 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/23036599
Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus. Lovatel GA, Elsner VR, Bertoldi K, Vanzella C, Moysés Fdos S, Vizuete A, Spindler C, Cechinel LR, Netto CA, Muotri AR, Siqueira IR Neurobiology of learning and memory 23357282 Neurobiol Learn Mem 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23357282
Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. Trujillo CA, Negraes PD, Schwindt TT, Lameu C, Carromeu C, Muotri AR, Pesquero JB, Cerqueira DM, Pillat MM, de Souza HD, Turaça LT, Abreu JG, Ulrich H The Journal of biological chemistry 23132855 J Biol Chem 2012 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/23132855
Modeling autism spectrum disorders with human neurons. Beltrão-Braga PC, Muotri AR Brain research 26854137 Brain Res 2017 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/26854137
The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. Acab A, Muotri AR Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 25851569 Neurotherapeutics 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25851569
Systematic optimization of human pluripotent stem cells media using Design of Experiments. Marinho PA, Chailangkarn T, Muotri AR Scientific reports 25940691 Sci Rep 2015 May 5 https://www.ncbi.nlm.nih.gov/pubmed/25940691
Brains, genes, and primates. Izpisua Belmonte JC, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F Neuron 25950631 Neuron 2015 May 6 https://www.ncbi.nlm.nih.gov/pubmed/25950631
LINE-1: creators of neuronal diversity. Thomas CA, Muotri AR Frontiers in bioscience (Elite edition) 22201983 Front Biosci (Elite Ed) 2012 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/22201983
Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids. Trujillo CA, Adams JW, Negraes PD, Carromeu C, Tejwani L, Acab A, Tsuda B, Thomas CA, Sodhi N, Fichter KM, Romero S, Zanella F, Sejnowski TJ, Ulrich H, Muotri AR EMBO molecular medicine 33501759 EMBO Mol Med 2021 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/33501759
Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment. Adams JW, Vinokur A, de Souza JS, Austria C, Guerra BS, Herai RH, Wahlin KJ, Muotri AR Cell reports 38416640 Cell Rep 2024 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/38416640
L1 Retrotransposition in Neural Progenitor Cells. Muotri AR Methods in molecular biology (Clifton, N.J.) 26895053 Methods Mol Biol 2016 https://www.ncbi.nlm.nih.gov/pubmed/26895053
A human neurodevelopmental model for Williams syndrome. Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR Nature 27509850 Nature 2016 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/27509850
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR Molecular psychiatry 27378147 Mol Psychiatry 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/27378147
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR Nature neuroscience 25108912 Nat Neurosci 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25108912
KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G Proceedings of the National Academy of Sciences of the United States of America 26733678 Proc Natl Acad Sci U S A 2016 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/26733678
Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony. Vessoni AT, Herai RH, Karpiak JV, Leal AM, Trujillo CA, Quinet A, Agnez Lima LF, Menck CF, Muotri AR Human molecular genetics 26755826 Hum Mol Genet 2016 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/26755826
Altered neuronal network and rescue in a human MECP2 duplication model. Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri AR Molecular psychiatry 26347316 Mol Psychiatry 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26347316
Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG Journal of neurology research 24348887 J Neurol Res 2011 https://www.ncbi.nlm.nih.gov/pubmed/24348887
Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Hrvoj-Mihic B, Marchetto MC, Gage FH, Semendeferi K, Muotri AR Biological psychiatry 24041506 Biol Psychiatry 2014 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/24041506
Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri AR, Haddad GG Neuroscience 25559931 Neuroscience 2015 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/25559931
Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. Kim JJ, Savas JN, Miller MT, Hu X, Carromeu C, Lavallée-Adam M, Freitas BCG, Muotri AR, Yates JR 3rd, Ghosh A PloS one 30789962 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/30789962
L1 retrotransposition in neurons is modulated by MeCP2. Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH Nature 21085180 Nature 2010 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/21085180
Characterizing complex structural variation in germline and somatic genomes. Quinlan AR, Hall IM Trends in genetics : TIG 22094265 Trends Genet 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22094265
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Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogramming. Quinlan AR, Boland MJ, Leibowitz ML, Shumilina S, Pehrson SM, Baldwin KK, Hall IM Cell stem cell 21982236 Cell Stem Cell 2011 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/21982236
Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome. Quinlan AR, Clark RA, Sokolova S, Leibowitz ML, Zhang Y, Hurles ME, Mell JC, Hall IM Genome research 20308636 Genome Res 2010 May https://www.ncbi.nlm.nih.gov/pubmed/20308636
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Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations. Malhotra A, Wang Y, Waters J, Chen K, Meric-Bernstam F, Hall IM, Navin NE Genome medicine 25729435 Genome Med 2015 https://www.ncbi.nlm.nih.gov/pubmed/25729435
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Mosaic copy number variation in human neurons. McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH Science (New York, N.Y.) 24179226 Science 2013 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/24179226
Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms. Malhotra A, Lindberg M, Faust GG, Leibowitz ML, Clark RA, Layer RM, Quinlan AR, Hall IM Genome research 23410887 Genome Res 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23410887
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Noninvasive molecular imaging of tuberculosis-associated inflammation with radioiodinated DPA-713. Foss CA, Harper JS, Wang H, Pomper MG, Jain SK The Journal of infectious diseases 23901092 J Infect Dis 2013 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/23901092
Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas. Skerry C, Harper J, Klunk M, Bishai WR, Jain SK PloS one 22761866 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22761866
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The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography. Zhang Z, Ordonez AA, Smith-Jones P, Wang H, Gogarty KR, Daryaee F, Bambarger LE, Chang YS, Jain SK, Tonge PJ PloS one 28151985 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/28151985
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Cross-talk between KLF4 and STAT3 regulates axon regeneration. Qin S, Zou Y, Zhang CL Nature communications 24129709 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/24129709
Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain. Niu W, Zang T, Wang LL, Zou Y, Zhang CL Stem cell reports 30318292 Stem Cell Reports 2018 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/30318292
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis. Beckervordersandforth R, Zhang CL, Lie DC Cold Spring Harbor perspectives in biology 26430216 Cold Spring Harb Perspect Biol 2015 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/26430216
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Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons. Tang Y, Liu ML, Zang T, Zhang CL Frontiers in molecular neuroscience 29163034 Front Mol Neurosci 2017 https://www.ncbi.nlm.nih.gov/pubmed/29163034
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Liu ML, Zang T, Zou Y, Chang JC, Gibson JR, Huber KM, Zhang CL Nature communications 23873306 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23873306
Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming. Smith DK, Yang J, Liu ML, Zhang CL Stem cell reports 28157484 Stem Cell Reports 2016 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/28157484
The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Zou Y, Niu W, Qin S, Downes M, Burns DK, Zhang CL Molecular and cellular biology 23028043 Mol Cell Biol 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/23028043
TLX: A master regulator for neural stem cell maintenance and neurogenesis. Islam MM, Zhang CL Biochimica et biophysica acta 24930777 Biochim Biophys Acta 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/24930777
In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R, Zhang CL Nature cell biology 24056302 Nat Cell Biol 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/24056302
In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Su Z, Niu W, Liu ML, Zou Y, Zhang CL Nature communications 24569435 Nat Commun 2014 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/24569435
The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord. Wang LL, Su Z, Tai W, Zou Y, Xu XM, Zhang CL Cell reports 27732862 Cell Rep 2016 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/27732862
Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming. Islam MM, Smith DK, Niu W, Fang S, Iqbal N, Sun G, Shi Y, Zhang CL Stem cell reports 26607952 Stem Cell Reports 2015 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/26607952
Orphan nuclear receptor TLX regulates astrogenesis by modulating BMP signaling. Qin S, Niu W, Iqbal N, Smith DK, Zhang CL Frontiers in neuroscience 24782704 Front Neurosci 2014 https://www.ncbi.nlm.nih.gov/pubmed/24782704
A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses. Adimora NJ, Jones DP, Kemp ML Antioxidants & redox signaling 20121341 Antioxid Redox Signal 2010 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/20121341
Systemic redox regulation of cellular information processing. Dwivedi G, Kemp ML Antioxidants & redox signaling 21939387 Antioxid Redox Signal 2012 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/21939387
Redox processes inform multivariate transdifferentiation trajectories associated with TGFβ-induced epithelial-mesenchymal transition. Prasanphanich AF, Arencibia CA, Kemp ML Free radical biology & medicine 25088330 Free Radic Biol Med 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25088330
Quantification of degeneracy in biological systems for characterization of functional interactions between modules. Li Y, Dwivedi G, Huang W, Kemp ML, Yi Y Journal of theoretical biology 22619750 J Theor Biol 2012 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/22619750
Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism. Rivet CA, Kniss-James AS, Gran MA, Potnis A, Hill A, Lu H, Kemp ML PloS one 27526200 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27526200
Dynamic Redox Regulation of IL-4 Signaling. Dwivedi G, Gran MA, Bagchi P, Kemp ML PLoS computational biology 26562652 PLoS Comput Biol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26562652
Spatially-resolved intracellular sensing of hydrogen peroxide in living cells. Warren EA, Netterfield TS, Sarkar S, Kemp ML, Payne CK Scientific reports 26585385 Sci Rep 2015 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/26585385
Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase. Kippner LE, Finn NA, Shukla S, Kemp ML BMC systems biology 21995976 BMC Syst Biol 2011 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/21995976
Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay. Prasanphanich AF, White DE, Gran MA, Kemp ML PLoS computational biology 27851764 PLoS Comput Biol 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27851764
TiO(2) Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona. Runa S, Lakadamyali M, Kemp ML, Payne CK The journal of physical chemistry. B 28844138 J Phys Chem B 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28844138
A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity. Finn NA, Findley HW, Kemp ML PLoS computational biology 21935349 PLoS Comput Biol 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21935349
Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells. Finn NA, Kemp ML Molecular bioSystems 22134636 Mol Biosyst 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22134636
Single cell transcriptional analysis reveals novel innate immune cell types. Kippner LE, Kim J, Gibson G, Kemp ML PeerJ 25024920 PeerJ 2014 https://www.ncbi.nlm.nih.gov/pubmed/25024920
Tuning and controlling gene expression noise in synthetic gene networks. Murphy KF, Adams RM, Wang X, Balázsi G, Collins JJ Nucleic acids research 20211838 Nucleic Acids Res 2010 May https://www.ncbi.nlm.nih.gov/pubmed/20211838
Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli. Quan S, Ray JC, Kwota Z, Duong T, Balázsi G, Cooper TF, Monds RD PLoS genetics 22253602 PLoS Genet 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22253602
The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response. Tiwari A, Balázsi G, Gennaro ML, Igoshin OA Physical biology 20733247 Phys Biol 2010 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/20733247
Phenotypic heterogeneity promotes adaptive evolution. Bódi Z, Farkas Z, Nevozhay D, Kalapis D, Lázár V, Csörgő B, Nyerges Á, Szamecz B, Fekete G, Papp B, Araújo H, Oliveira JL, Moura G, Santos MAS, Székely T Jr, Balázsi G, Pál C PLoS biology 28486496 PLoS Biol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28486496
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. Lee J, Lee J, Farquhar KS, Yun J, Frankenberger CA, Bevilacqua E, Yeung K, Kim EJ, Balázsi G, Rosner MR Proceedings of the National Academy of Sciences of the United States of America 24395801 Proc Natl Acad Sci U S A 2014 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/24395801
Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection. Rohde KH, Veiga DF, Caldwell S, Balázsi G, Russell DG PLoS pathogens 22737072 PLoS Pathog 2012 https://www.ncbi.nlm.nih.gov/pubmed/22737072
Role of network-mediated stochasticity in mammalian drug resistance. Farquhar KS, Charlebois DA, Szenk M, Cohen J, Nevozhay D, Balázsi G Nature communications 31235692 Nat Commun 2019 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/31235692
Disadvantages and benefits of evolved unicellularity versus multicellularity in budding yeast. Kuzdzal-Fick JJ, Chen L, Balázsi G Ecology and evolution 31410258 Ecol Evol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31410258
Network inference and network response identification: moving genome-scale data to the next level of biological discovery. Veiga DF, Dutta B, Balázsi G Molecular bioSystems 20174676 Mol Biosyst 2010 Mar https://www.ncbi.nlm.nih.gov/pubmed/20174676
Efflux Pump Control Alters Synthetic Gene Circuit Function. Diao J, Charlebois DA, Nevozhay D, Bódi Z, Pál C, Balázsi G ACS synthetic biology 27111147 ACS Synth Biol 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27111147
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Stress-response balance drives the evolution of a network module and its host genome. González C, Ray JC, Manhart M, Adams RM, Nevozhay D, Morozov AV, Balázsi G Molecular systems biology 26324468 Mol Syst Biol 2015 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/26324468
Transferring a synthetic gene circuit from yeast to mammalian cells. Nevozhay D, Zal T, Balázsi G Nature communications 23385595 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23385595
Mapping the environmental fitness landscape of a synthetic gene circuit. Nevozhay D, Adams RM, Van Itallie E, Bennett MR, Balázsi G PLoS computational biology 22511863 PLoS Comput Biol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22511863
Cellular decision making and biological noise: from microbes to mammals. Balázsi G, van Oudenaarden A, Collins JJ Cell 21414483 Cell 2011 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/21414483
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Negative Regulation Gene Circuits for Efflux Pump Control. Charlebois DA, Diao J, Nevozhay D, Balázsi G Methods in molecular biology (Clifton, N.J.) 29754221 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29754221
Two-dimensionality of yeast colony expansion accompanied by pattern formation. Chen L, Noorbakhsh J, Adams RM, Samaniego-Evans J, Agollah G, Nevozhay D, Kuzdzal-Fick J, Mehta P, Balázsi G PLoS computational biology 25504059 PLoS Comput Biol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25504059
Cellular Growth Arrest and Persistence from Enzyme Saturation. Ray JC, Wickersheim ML, Jalihal AP, Adeshina YO, Cooper TF, Balázsi G PLoS computational biology 27010473 PLoS Comput Biol 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27010473
Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia. Satake N, Duong C, Chen C, Barisone GA, Diaz E, Tuscano J, Rocke DM, Nolta J, Nitin N British journal of haematology 25196579 Br J Haematol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25196579
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Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma. Ngo T, Corrales A, Bourne T, Elmojahid S, Lam KS, Díaz E Frontiers in molecular biosciences 30838212 Front Mol Biosci 2019 https://www.ncbi.nlm.nih.gov/pubmed/30838212
Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. Kaur I, Yarov-Yarovoy V, Kirk LM, Plambeck KE, Barragan EV, Ontiveros ES, Díaz E The Journal of neuroscience : the official journal of the Society for Neuroscience 27445135 J Neurosci 2016 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/27445135
Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain. Kirk LM, Ti SW, Bishop HI, Orozco-Llamas M, Pham M, Trimmer JS, Díaz E The Journal of comparative neurology 26660156 J Comp Neurol 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/26660156
Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Speca DJ, Trimmer JS, Peterson AS, Díaz E Mammalian genome : official journal of the International Mammalian Genome Society 28894906 Mamm Genome 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28894906
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How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos? Gelens L, Huang KC, Ferrell JE Jr Cell reports 26212326 Cell Rep 2015 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/26212326
Interplay between the localization and kinetics of phosphorylation in flagellar pole development of the bacterium Caulobacter crescentus. Tropini C, Huang KC PLoS computational biology 22876167 PLoS Comput Biol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22876167
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Chiral twisting in a bacterial cytoskeletal polymer affects filament size and orientation. Shi H, Quint DA, Grason GM, Gopinathan A, Huang KC Nature communications 32179732 Nat Commun 2020 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/32179732
Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance. Aranda-Díaz A, Obadia B, Dodge R, Thomsen T, Hallberg ZF, Güvener ZT, Ludington WB, Huang KC eLife 31995029 Elife 2020 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/31995029
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Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs. Ng KM, Aranda-Díaz A, Tropini C, Frankel MR, Van Treuren W, O'Loughlin CT, Merrill BD, Yu FB, Pruss KM, Oliveira RA, Higginbottom SK, Neff NF, Fischbach MA, Xavier KB, Sonnenburg JL, Huang KC Cell host & microbe 31726029 Cell Host Microbe 2019 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/31726029
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Dimer dynamics and filament organization of the bacterial cell division protein FtsA. Hsin J, Fu R, Huang KC Journal of molecular biology 23871894 J Mol Biol 2013 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/23871894
The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction. Sundararajan K, Miguel A, Desmarais SM, Meier EL, Casey Huang K, Goley ED Nature communications 26099469 Nat Commun 2015 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/26099469
How and why cells grow as rods. Chang F, Huang KC BMC biology 25185019 BMC Biol 2014 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/25185019
The bacterial actin MreB rotates, and rotation depends on cell-wall assembly. van Teeffelen S, Wang S, Furchtgott L, Huang KC, Wingreen NS, Shaevitz JW, Gitai Z Proceedings of the National Academy of Sciences of the United States of America 21903929 Proc Natl Acad Sci U S A 2011 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/21903929
Response of Escherichia coli growth rate to osmotic shock. Rojas E, Theriot JA, Huang KC Proceedings of the National Academy of Sciences of the United States of America 24821776 Proc Natl Acad Sci U S A 2014 May 27 https://www.ncbi.nlm.nih.gov/pubmed/24821776
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How to Build a Bacterial Cell: MreB as the Foreman of E. coli Construction. Shi H, Bratton BP, Gitai Z, Huang KC Cell 29522748 Cell 2018 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/29522748
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Bacterial division. Mechanical crack propagation drives millisecond daughter cell separation in Staphylococcus aureus. Zhou X, Halladin DK, Rojas ER, Koslover EF, Lee TK, Huang KC, Theriot JA Science (New York, N.Y.) 25931560 Science 2015 May 1 https://www.ncbi.nlm.nih.gov/pubmed/25931560
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The role of hydrolases in bacterial cell-wall growth. Lee TK, Huang KC Current opinion in microbiology 24035761 Curr Opin Microbiol 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24035761
Optimal dynamics for quality control in spatially distributed mitochondrial networks. Patel PK, Shirihai O, Huang KC PLoS computational biology 23874166 PLoS Comput Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23874166
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Strain Library Imaging Protocol for high-throughput, automated single-cell microscopy of large bacterial collections arrayed on multiwell plates. Shi H, Colavin A, Lee TK, Huang KC Nature protocols 28125106 Nat Protoc 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/28125106
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA Cell 27238023 Cell 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27238023
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Single-molecule imaging reveals modulation of cell wall synthesis dynamics in live bacterial cells. Lee TK, Meng K, Shi H, Huang KC Nature communications 27774981 Nat Commun 2016 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/27774981
Posttranslational acetylation of α-tubulin constrains protofilament number in native microtubules. Cueva JG, Hsin J, Huang KC, Goodman MB Current biology : CB 22658592 Curr Biol 2012 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/22658592
Peptidoglycan at its peaks: how chromatographic analyses can reveal bacterial cell wall structure and assembly. Desmarais SM, De Pedro MA, Cava F, Huang KC Molecular microbiology 23679048 Mol Microbiol 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23679048
Macromolecules that prefer their membranes curvy. Huang KC, Ramamurthi KS Molecular microbiology 20444099 Mol Microbiol 2010 May https://www.ncbi.nlm.nih.gov/pubmed/20444099
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A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis. Bartlett TM, Bratton BP, Duvshani A, Miguel A, Sheng Y, Martin NR, Nguyen JP, Persat A, Desmarais SM, VanNieuwenhze MS, Huang KC, Zhu J, Shaevitz JW, Gitai Z Cell 28086090 Cell 2017 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/28086090
Rapid, precise quantification of bacterial cellular dimensions across a genomic-scale knockout library. Ursell T, Lee TK, Shiomi D, Shi H, Tropini C, Monds RD, Colavin A, Billings G, Bhaya-Grossman I, Broxton M, Huang BE, Niki H, Huang KC BMC biology 28222723 BMC Biol 2017 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/28222723
Homeostatic Cell Growth Is Accomplished Mechanically through Membrane Tension Inhibition of Cell-Wall Synthesis. Rojas ER, Huang KC, Theriot JA Cell systems 29203279 Cell Syst 2017 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/29203279
Precise regulation of the relative rates of surface area and volume synthesis in bacterial cells growing in dynamic environments. Shi H, Hu Y, Odermatt PD, Gonzalez CG, Zhang L, Elias JE, Chang F, Huang KC Nature communications 33785742 Nat Commun 2021 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/33785742
Variations in the binding pocket of an inhibitor of the bacterial division protein FtsZ across genotypes and species. Miguel A, Hsin J, Liu T, Tang G, Altman RB, Huang KC PLoS computational biology 25811761 PLoS Comput Biol 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25811761
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A dynamically assembled cell wall synthesis machinery buffers cell growth. Lee TK, Tropini C, Hsin J, Desmarais SM, Ursell TS, Gong E, Gitai Z, Monds RD, Huang KC Proceedings of the National Academy of Sciences of the United States of America 24550500 Proc Natl Acad Sci U S A 2014 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/24550500
Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wang CC, Jamal L, Janes KA Wiley interdisciplinary reviews. Systems biology and medicine 21898857 Wiley Interdiscip Rev Syst Biol Med 2012 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/21898857
An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Jensen KJ, Garmaroudi FS, Zhang J, Lin J, Boroomand S, Zhang M, Luo Z, Yang D, Luo H, McManus BM, Janes KA Cell host & microbe 23332156 Cell Host Microbe 2013 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/23332156
Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles. Bajikar SS, Fuchs C, Roller A, Theis FJ, Janes KA Proceedings of the National Academy of Sciences of the United States of America 24449900 Proc Natl Acad Sci U S A 2014 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/24449900
Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state. Wang L, Paudel BB, McKnight RA, Janes KA Nature communications 37055441 Nat Commun 2023 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/37055441
Identifying single-cell molecular programs by stochastic profiling. Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS Nature methods 20228812 Nat Methods 2010 Apr https://www.ncbi.nlm.nih.gov/pubmed/20228812
Multiscale models of cell signaling. Bajikar SS, Janes KA Annals of biomedical engineering 22476894 Ann Biomed Eng 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22476894
TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA Science signaling 27273097 Sci Signal 2016 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/27273097
RUNX1 and its understudied role in breast cancer. Janes KA Cell cycle (Georgetown, Tex.) 22024923 Cell Cycle 2011 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/22024923
Paring down signaling complexity. Janes KA Nature biotechnology 20622836 Nat Biotechnol 2010 Jul https://www.ncbi.nlm.nih.gov/pubmed/20622836
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Bajikar SS, Wang CC, Borten MA, Pereira EJ, Atkins KA, Janes KA Developmental cell 29161592 Dev Cell 2017 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/29161592
Simultaneous profiling of 194 distinct receptor transcripts in human cells. Kang BH, Jensen KJ, Hatch JA, Janes KA Science signaling 23921087 Sci Signal 2013 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/23921087
Models of signalling networks - what cell biologists can gain from them and give to them. Janes KA, Lauffenburger DA Journal of cell science 23720376 J Cell Sci 2013 May 1 https://www.ncbi.nlm.nih.gov/pubmed/23720376
Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cells. Wang L, Janes KA Nature protocols 23306461 Nat Protoc 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23306461
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA Nature cell biology 24658685 Nat Cell Biol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24658685
Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection. Garmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM Proceedings of the National Academy of Sciences of the United States of America 20833815 Proc Natl Acad Sci U S A 2010 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/20833815
Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Wang L, Brugge JS, Janes KA Proceedings of the National Academy of Sciences of the United States of America 21873240 Proc Natl Acad Sci U S A 2011 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/21873240
Modeling the latent dimensions of multivariate signaling datasets. Jensen KJ, Janes KA Physical biology 22871687 Phys Biol 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22871687
A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. Bose AK, Janes KA Molecular & cellular proteomics : MCP 23233447 Mol Cell Proteomics 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23233447
Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting. Jensen KJ, Moyer CB, Janes KA Cell systems 26942229 Cell Syst 2016 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/26942229
A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR Cancer research 20631065 Cancer Res 2010 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/20631065
Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer. Yin PT, Shah S, Pasquale NJ, Garbuzenko OB, Minko T, Lee KB Biomaterials 26720500 Biomaterials 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26720500
Controlling differentiation of adipose-derived stem cells using combinatorial graphene hybrid-pattern arrays. Kim TH, Shah S, Yang L, Yin PT, Hossain MK, Conley B, Choi JW, Lee KB ACS nano 25840606 ACS Nano 2015 https://www.ncbi.nlm.nih.gov/pubmed/25840606
Engineering Stem Cells for Biomedical Applications. Yin PT, Han E, Lee KB Advanced healthcare materials 25772134 Adv Healthc Mater 2016 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/25772134
An upconversion nanoparticle with orthogonal emissions using dual NIR excitations for controlled two-way photoswitching. Lai J, Zhang Y, Pasquale N, Lee KB Angewandte Chemie (International ed. in English) 25349100 Angew Chem Int Ed Engl 2014 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/25349100
A step closer to complete chemical reprogramming for generating iPS cells. Solanki A, Lee KB Chembiochem : a European journal of chemical biology 20183843 Chembiochem 2010 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/20183843
Multimodal magnetic core-shell nanoparticles for effective stem-cell differentiation and imaging. Shah B, Yin PT, Ghoshal S, Lee KB Angewandte Chemie (International ed. in English) 23650180 Angew Chem Int Ed Engl 2013 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/23650180
Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release. Lai J, Shah BP, Garfunkel E, Lee KB ACS nano 23445171 ACS Nano 2013 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/23445171
Hybrid upconversion nanomaterials for optogenetic neuronal control. Shah S, Liu JJ, Pasquale N, Lai J, McGowan H, Pang ZP, Lee KB Nanoscale 26415758 Nanoscale 2015 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/26415758
Large-Scale Nanoelectrode Arrays to Monitor the Dopaminergic Differentiation of Human Neural Stem Cells. Kim TH, Yea CH, Chueng ST, Yin PT, Conley B, Dardir K, Pak Y, Jung GY, Choi JW, Lee KB Advanced materials (Deerfield Beach, Fla.) 26390254 Adv Mater 2015 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/26390254
Incorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells. Jung D, Minami I, Patel S, Lee J, Jiang B, Yuan Q, Li L, Kobayashi S, Chen Y, Lee KB, Nakatsuji N Journal of nanobiotechnology 22686683 J Nanobiotechnology 2012 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/22686683
Generation of a library of non-toxic quantum dots for cellular imaging and siRNA delivery. Subramaniam P, Lee SJ, Shah S, Patel S, Starovoytov V, Lee KB Advanced materials (Deerfield Beach, Fla.) 22744954 Adv Mater 2012 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/22744954
Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells. Yin PT, Shah BP, Lee KB Small (Weinheim an der Bergstrasse, Germany) 24947843 Small 2014 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/24947843
Core-shell nanoparticle-based peptide therapeutics and combined hyperthermia for enhanced cancer cell apoptosis. Shah BP, Pasquale N, De G, Tan T, Ma J, Lee KB ACS nano 25133971 ACS Nano 2014 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/25133971
Graphene-encapsulated nanoparticle-based biosensor for the selective detection of cancer biomarkers. Myung S, Solanki A, Kim C, Park J, Kim KS, Lee KB Advanced materials (Deerfield Beach, Fla.) 21469221 Adv Mater 2011 May 17 https://www.ncbi.nlm.nih.gov/pubmed/21469221
Synergistic induction of apoptosis in brain cancer cells by targeted codelivery of siRNA and anticancer drugs. Kim C, Shah BP, Subramaniam P, Lee KB Molecular pharmaceutics 21793576 Mol Pharm 2011 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/21793576
Guiding stem cell differentiation into oligodendrocytes using graphene-nanofiber hybrid scaffolds. Shah S, Yin PT, Uehara TM, Chueng ST, Yang L, Lee KB Advanced materials (Deerfield Beach, Fla.) 24668911 Adv Mater 2014 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/24668911
Label-free polypeptide-based enzyme detection using a graphene-nanoparticle hybrid sensor. Myung S, Yin PT, Kim C, Park J, Solanki A, Reyes PI, Lu Y, Kim KS, Lee KB Advanced materials (Deerfield Beach, Fla.) 22961629 Adv Mater 2012 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/22961629
Polarization-controlled differentiation of human neural stem cells using synergistic cues from the patterns of carbon nanotube monolayer coating. Park SY, Choi DS, Jin HJ, Park J, Byun KE, Lee KB, Hong S ACS nano 21568294 ACS Nano 2011 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/21568294
Carbon nanotube monolayer cues for osteogenesis of mesenchymal stem cells. Baik KY, Park SY, Heo K, Lee KB, Hong S Small (Weinheim an der Bergstrasse, Germany) 21425459 Small 2011 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/21425459
Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Kamei K, Ohashi M, Gschweng E, Ho Q, Suh J, Tang J, For Yu ZT, Clark AT, Pyle AD, Teitell MA, Lee KB, Witte ON, Tseng HR Lab on a chip 20390128 Lab Chip 2010 May 7 https://www.ncbi.nlm.nih.gov/pubmed/20390128
Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bioapplications. Yin PT, Shah S, Chhowalla M, Lee KB Chemical reviews 25692385 Chem Rev 2015 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/25692385
Nanotechnology-Based Approaches for Guiding Neural Regeneration. Shah S, Solanki A, Lee KB Accounts of chemical research 26653885 Acc Chem Res 2016 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/26653885
3D graphene oxide-encapsulated gold nanoparticles to detect neural stem cell differentiation. Kim TH, Lee KB, Choi JW Biomaterials 23937915 Biomaterials 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/23937915
Multidimensional nanomaterials for the control of stem cell fate. Chueng SD, Yang L, Zhang Y, Lee KB Nano convergence 28191433 Nano Converg 2016 https://www.ncbi.nlm.nih.gov/pubmed/28191433
Advanced Gene Manipulation Methods for Stem Cell Theranostics. Rathnam C, Chueng SD, Yang L, Lee KB Theranostics 28824715 Theranostics 2017 https://www.ncbi.nlm.nih.gov/pubmed/28824715
Development of Photoactivated Fluorescent N-Hydroxyoxindoles and Their Application for Cell-Selective Imaging. Lai J, Yu A, Yang L, Zhang Y, Shah BP, Lee KB Chemistry (Weinheim an der Bergstrasse, Germany) 27004772 Chemistry 2016 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/27004772
NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation. Patel S, Jung D, Yin PT, Carlton P, Yamamoto M, Bando T, Sugiyama H, Lee KB ACS nano 25133310 ACS Nano 2014 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/25133310
Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery. Jung J, Solanki A, Memoli KA, Kamei K, Kim H, Drahl MA, Williams LJ, Tseng HR, Lee K Angewandte Chemie (International ed. in English) 19950159 Angew Chem Int Ed Engl 2010 https://www.ncbi.nlm.nih.gov/pubmed/19950159
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Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice. Kittelberger KA, Piazza F, Tesco G, Reijmers LG PloS one 22238679 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22238679
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Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients. Yong WH, Shabihkhani M, Telesca D, Yang S, Tso JL, Menjivar JC, Wei B, Lucey GM, Mareninov S, Chen Z, Liau LM, Lai A, Nelson SF, Cloughesy TF, Tso CL PloS one 26506620 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/26506620
Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications. Mudanyali O, Tseng D, Oh C, Isikman SO, Sencan I, Bishara W, Oztoprak C, Seo S, Khademhosseini B, Ozcan A Lab on a chip 20401422 Lab Chip 2010 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/20401422
Lensfree microscopy on a cellphone. Tseng D, Mudanyali O, Oztoprak C, Isikman SO, Sencan I, Yaglidere O, Ozcan A Lab on a chip 20445943 Lab Chip 2010 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/20445943
High-throughput lens-free blood analysis on a chip. Seo S, Isikman SO, Sencan I, Mudanyali O, Su TW, Bishara W, Erlinger A, Ozcan A Analytical chemistry 20450181 Anal Chem 2010 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/20450181
On-chip differential interference contrast microscopy using lensless digital holography. Oh C, Isikman SO, Khademhosseinieh B, Ozcan A Optics express 20389485 Opt Express 2010 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/20389485
Lens-free optical tomographic microscope with a large imaging volume on a chip. Isikman SO, Bishara W, Mavandadi S, Yu FW, Feng S, Lau R, Ozcan A Proceedings of the National Academy of Sciences of the United States of America 21504943 Proc Natl Acad Sci U S A 2011 May 3 https://www.ncbi.nlm.nih.gov/pubmed/21504943
Combined reflection and transmission microscope for telemedicine applications in field settings. Biener G, Greenbaum A, Isikman SO, Lee K, Tseng D, Ozcan A Lab on a chip 21709875 Lab Chip 2011 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/21709875
Lensless fluorescent microscopy on a chip. Coskun AF, Su TW, Sencan I, Ozcan A Journal of visualized experiments : JoVE 21876522 J Vis Exp 2011 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/21876522
Partially coherent lensfree tomographic microscopy [Invited]. Isikman SO, Bishara W, Ozcan A Applied optics 22193016 Appl Opt 2011 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/22193016
Optofluidic Tomography on a Chip. Isikman SO, Bishara W, Zhu H, Ozcan A Applied physics letters 21580801 Appl Phys Lett 2011 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/21580801
Portable and cost-effective pixel super-resolution on-chip microscope for telemedicine applications. Bishara W, Sikora U, Mudanyali O, Su TW, Yaglidere O, Luckhart S, Ozcan A Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22256247 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22256247
Holographic opto-fluidic microscopy. Bishara W, Zhu H, Ozcan A Optics express 21197025 Opt Express 2010 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/21197025
Lensfree fluorescent on-chip imaging of transgenic Caenorhabditis elegans over an ultra-wide field-of-view. Coskun AF, Sencan I, Su TW, Ozcan A PloS one 21253611 PLoS One 2011 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/21253611
Quantification of plant chlorophyll content using Google Glass. Cortazar B, Koydemir HC, Tseng D, Feng S, Ozcan A Lab on a chip 25669673 Lab Chip 2015 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/25669673
High-throughput and label-free single nanoparticle sizing based on time-resolved on-chip microscopy. McLeod E, Dincer TU, Veli M, Ertas YN, Nguyen C, Luo W, Greenbaum A, Feizi A, Ozcan A ACS nano 25688665 ACS Nano 2015 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/25688665
Wide-field computational color imaging using pixel super-resolved on-chip microscopy. Greenbaum A, Feizi A, Akbari N, Ozcan A Optics express 23736466 Opt Express 2013 May 20 https://www.ncbi.nlm.nih.gov/pubmed/23736466
Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array. Navruz I, Coskun AF, Wong J, Mohammad S, Tseng D, Nagi R, Phillips S, Ozcan A Lab on a chip 23939637 Lab Chip 2013 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/23939637
High-throughput lensfree 3D tracking of human sperms reveals rare statistics of helical trajectories. Su TW, Xue L, Ozcan A Proceedings of the National Academy of Sciences of the United States of America 22988076 Proc Natl Acad Sci U S A 2012 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/22988076
Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy. Greenbaum A, Luo W, Su TW, Göröcs Z, Xue L, Isikman SO, Coskun AF, Mudanyali O, Ozcan A Nature methods 22936170 Nat Methods 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22936170
Giga-pixel lensfree holographic microscopy and tomography using color image sensors. Isikman SO, Greenbaum A, Luo W, Coskun AF, Ozcan A PloS one 22984606 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22984606
Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view. Coskun AF, Cetin AE, Galarreta BC, Alvarez DA, Altug H, Ozcan A Scientific reports 25346102 Sci Rep 2014 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/25346102
Biomedical imaging and sensing using flatbed scanners. Göröcs Z, Ozcan A Lab on a chip 24965011 Lab Chip 2014 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/24965011
Lensfree On-Chip Microscopy and Tomography for Bio-Medical Applications. Isikman SO, Bishara W, Mudanyali O, Sencan I, Su TW, Tseng D, Yaglidere O, Sikora U, Ozcan A IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society 24478572 IEEE J Sel Top Quantum Electron 2011 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/24478572
Analysis of Diffractive Optical Neural Networks and Their Integration with Electronic Neural Networks. Mengu D, Luo Y, Rivenson Y, Ozcan A IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society 33223801 IEEE J Sel Top Quantum Electron 2020 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/33223801
Nanofabrication using near-field optical probes. McLeod E, Ozcan A Journal of laboratory automation 22713756 J Lab Autom 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22713756
Lensfree holographic imaging of antibody microarrays for high-throughput detection of leukocyte numbers and function. Stybayeva G, Mudanyali O, Seo S, Silangcruz J, Macal M, Ramanculov E, Dandekar S, Erlinger A, Ozcan A, Revzin A Analytical chemistry 20359168 Anal Chem 2010 May 1 https://www.ncbi.nlm.nih.gov/pubmed/20359168
Giga-pixel fluorescent imaging over an ultra-large field-of-view using a flatbed scanner. Göröcs Z, Ling Y, Yu MD, Karahalios D, Mogharabi K, Lu K, Wei Q, Ozcan A Lab on a chip 24080766 Lab Chip 2013 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/24080766
Field-portable pixel super-resolution colour microscope. Greenbaum A, Akbari N, Feizi A, Luo W, Ozcan A PloS one 24086742 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24086742
On-chip cytometry using plasmonic nanoparticle enhanced lensfree holography. Wei Q, McLeod E, Qi H, Wan Z, Sun R, Ozcan A Scientific reports 23608952 Sci Rep 2013 https://www.ncbi.nlm.nih.gov/pubmed/23608952
Wide-field optical detection of nanoparticles using on-chip microscopy and self-assembled nanolenses. Mudanyali O, McLeod E, Luo W, Greenbaum A, Coskun AF, Hennequin Y, Allier CP, Ozcan A Nature photonics 24358054 Nat Photonics 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24358054
Computational imaging, sensing and diagnostics for global health applications. Coskun AF, Ozcan A Current opinion in biotechnology 24484875 Curr Opin Biotechnol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24484875
Albumin testing in urine using a smart-phone. Coskun AF, Nagi R, Sadeghi K, Phillips S, Ozcan A Lab on a chip 23995895 Lab Chip 2013 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/23995895
Lensfree computational microscopy tools for cell and tissue imaging at the point-of-care and in low-resource settings. Isikman SO, Greenbaum A, Lee M, Bishara W, Mudanyali O, Su TW, Ozcan A Analytical cellular pathology (Amsterdam) 22433451 Anal Cell Pathol (Amst) 2012 https://www.ncbi.nlm.nih.gov/pubmed/22433451
Maskless imaging of dense samples using pixel super-resolution based multi-height lensfree on-chip microscopy. Greenbaum A, Ozcan A Optics express 22330550 Opt Express 2012 Jan 30 https://www.ncbi.nlm.nih.gov/pubmed/22330550
Sperm trajectories form chiral ribbons. Su TW, Choi I, Feng J, Huang K, McLeod E, Ozcan A Scientific reports 23588811 Sci Rep 2013 https://www.ncbi.nlm.nih.gov/pubmed/23588811
Cost-effective and rapid blood analysis on a cell-phone. Zhu H, Sencan I, Wong J, Dimitrov S, Tseng D, Nagashima K, Ozcan A Lab on a chip 23392286 Lab Chip 2013 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/23392286
Flexible Plasmonic Sensors. Shir D, Ballard ZS, Ozcan A IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society 27547023 IEEE J Sel Top Quantum Electron 2016 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/27547023
Democratization of Nanoscale Imaging and Sensing Tools Using Photonics. McLeod E, Wei Q, Ozcan A Analytical chemistry 26068279 Anal Chem 2015 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/26068279
Tunable vapor-condensed nanolenses. McLeod E, Nguyen C, Huang P, Luo W, Veli M, Ozcan A ACS nano 24979060 ACS Nano 2014 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/24979060
Automated single-cell motility analysis on a chip using lensfree microscopy. Pushkarsky I, Liu Y, Weaver W, Su TW, Mudanyali O, Ozcan A, Di Carlo D Scientific reports 24739819 Sci Rep 2014 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/24739819
Crowd-sourced BioGames: managing the big data problem for next-generation lab-on-a-chip platforms. Mavandadi S, Dimitrov S, Feng S, Yu F, Yu R, Sikora U, Ozcan A Lab on a chip 22918378 Lab Chip 2012 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/22918378
On-chip biomedical imaging. Göröcs Z, Ozcan A IEEE reviews in biomedical engineering 23558399 IEEE Rev Biomed Eng 2013 https://www.ncbi.nlm.nih.gov/pubmed/23558399
Wide field-of-view lens-free fluorescent imaging on a chip. Coskun AF, Su TW, Ozcan A Lab on a chip 20379564 Lab Chip 2010 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/20379564
Compact and light-weight automated semen analysis platform using lensfree on-chip microscopy. Su TW, Erlinger A, Tseng D, Ozcan A Analytical chemistry 20836503 Anal Chem 2010 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/20836503
Smart technology for global access to healthcare. Ozcan A SPIE newsroom 20582244 SPIE Newsroom 2010 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/20582244
Multi-angle lensless digital holography for depth resolved imaging on a chip. Su TW, Isikman SO, Bishara W, Tseng D, Erlinger A, Ozcan A Optics express 20588819 Opt Express 2010 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/20588819
Lensless wide-field fluorescent imaging on a chip using compressive decoding of sparse objects. Coskun AF, Sencan I, Su TW, Ozcan A Optics express 20588904 Opt Express 2010 May 10 https://www.ncbi.nlm.nih.gov/pubmed/20588904
Lensfree on-chip microscopy over a wide field-of-view using pixel super-resolution. Bishara W, Su TW, Coskun AF, Ozcan A Optics express 20588977 Opt Express 2010 May 24 https://www.ncbi.nlm.nih.gov/pubmed/20588977
Optofluidic on-chip tomography. Isikman SO, Bishara W, Zhu H, Ozcan A Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22256312 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22256312
Toward giga-pixel nanoscopy on a chip: a computational wide-field look at the nano-scale without the use of lenses. McLeod E, Luo W, Mudanyali O, Greenbaum A, Ozcan A Lab on a chip 23592185 Lab Chip 2013 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/23592185
Wide-field fluorescent microscopy on a cell-phone. Zhu H, Yaglidere O, Su TW, Tseng D, Ozcan A Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22255900 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22255900
Optical detection and sizing of single nanoparticles using continuous wetting films. Hennequin Y, Allier CP, McLeod E, Mudanyali O, Migliozzi D, Ozcan A, Dinten JM ACS nano 23889001 ACS Nano 2013 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/23889001
Integrated rapid-diagnostic-test reader platform on a cellphone. Mudanyali O, Dimitrov S, Sikora U, Padmanabhan S, Navruz I, Ozcan A Lab on a chip 22596243 Lab Chip 2012 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/22596243
A personalized food allergen testing platform on a cellphone. Coskun AF, Wong J, Khodadadi D, Nagi R, Tey A, Ozcan A Lab on a chip 23254910 Lab Chip 2013 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/23254910
High-throughput screening of large volumes of whole blood using structured illumination and fluorescent on-chip imaging. Arpali SA, Arpali C, Coskun AF, Chiang HH, Ozcan A Lab on a chip 23047492 Lab Chip 2012 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/23047492
Spectral demultiplexing in holographic and fluorescent on-chip microscopy. Sencan I, Coskun AF, Sikora U, Ozcan A Scientific reports 24441627 Sci Rep 2014 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/24441627
Optoelectronic tweezers integrated with lensfree holographic microscopy for wide-field interactive cell and particle manipulation on a chip. Huang KW, Su TW, Ozcan A, Chiou PY Lab on a chip 23661233 Lab Chip 2013 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/23661233
Cellphone-based detection platform for rbST biomarker analysis in milk extracts using a microsphere fluorescence immunoassay. Ludwig SK, Zhu H, Phillips S, Shiledar A, Feng S, Tseng D, van Ginkel LA, Nielen MW, Ozcan A Analytical and bioanalytical chemistry 24972876 Anal Bioanal Chem 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/24972876
Lens-free computational imaging of capillary morphogenesis within three-dimensional substrates. Weidling J, Isikman SO, Greenbaum A, Ozcan A, Botvinick E Journal of biomedical optics 23235893 J Biomed Opt 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/23235893
Killing of targets by CD8 T cells in the mouse spleen follows the law of mass action. Ganusov VV, Barber DL, De Boer RJ PloS one 21283669 PLoS One 2011 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/21283669
Wide-field lensless fluorescent microscopy using a tapered fiber-optic faceplate on a chip. Coskun AF, Sencan I, Su TW, Ozcan A The Analyst 21283900 Analyst 2011 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/21283900
Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array. Bishara W, Sikora U, Mudanyali O, Su TW, Yaglidere O, Luckhart S, Ozcan A Lab on a chip 21365087 Lab Chip 2011 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/21365087
Quantum dot enabled detection of Escherichia coli using a cell-phone. Zhu H, Sikora U, Ozcan A The Analyst 22396952 Analyst 2012 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/22396952
Wide-field fluorescent microscopy and fluorescent imaging flow cytometry on a cell-phone. Zhu H, Ozcan A Journal of visualized experiments : JoVE 23603893 J Vis Exp 2013 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/23603893
BioGames: A Platform for Crowd-Sourced Biomedical Image Analysis and Telediagnosis. Mavandadi S, Feng S, Yu F, Dimitrov S, Yu R, Ozcan A Games for health journal 23724363 Games Health J 2012 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/23724363
Detection of waterborne parasites using field-portable and cost-effective lensfree microscopy. Mudanyali O, Oztoprak C, Tseng D, Erlinger A, Ozcan A Lab on a chip 20694255 Lab Chip 2010 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/20694255
Color and monochrome lensless on-chip imaging of Caenorhabditis elegans over a wide field-of-view. Isikman SO, Sencan I, Mudanyali O, Bishara W, Oztoprak C, Ozcan A Lab on a chip 20390127 Lab Chip 2010 May 7 https://www.ncbi.nlm.nih.gov/pubmed/20390127
Lensless fluorescent on-chip microscopy using a fiber-optic taper. Coskun AF, Sencan I, Su TW, Ozcan A Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 22255702 Annu Int Conf IEEE Eng Med Biol Soc 2011 https://www.ncbi.nlm.nih.gov/pubmed/22255702
Lensfree on-chip holography facilitates novel microscopy applications. Ozcan A, Isikman S, Mudanyali O, Tseng D, Sencan I SPIE newsroom 21643449 SPIE Newsroom 2010 May 19 https://www.ncbi.nlm.nih.gov/pubmed/21643449
Lensfree Fluorescent On-Chip Imaging using Compressive Sampling. Coskun AF, Su TW, Sencan I, Ozcan A Optics and photonics news 21546979 Opt Photonics News 2010 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/21546979
Field-portable lensfree tomographic microscope. Isikman SO, Bishara W, Sikora U, Yaglidere O, Yeah J, Ozcan A Lab on a chip 21573311 Lab Chip 2011 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/21573311
Optofluidic fluorescent imaging cytometry on a cell phone. Zhu H, Mavandadi S, Coskun AF, Yaglidere O, Ozcan A Analytical chemistry 21774454 Anal Chem 2011 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/21774454
Lensfree super-resolution holographic microscopy using wetting films on a chip. Mudanyali O, Bishara W, Ozcan A Optics express 21935102 Opt Express 2011 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/21935102
Field-portable reflection and transmission microscopy based on lensless holography. Lee M, Yaglidere O, Ozcan A Biomedical optics express 21991559 Biomed Opt Express 2011 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/21991559
Optical imaging techniques for point-of-care diagnostics. Zhu H, Isikman SO, Mudanyali O, Greenbaum A, Ozcan A Lab on a chip 23044793 Lab Chip 2013 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/23044793
A mathematical framework for combining decisions of multiple experts toward accurate and remote diagnosis of malaria using tele-microscopy. Mavandadi S, Feng S, Yu F, Dimitrov S, Nielsen-Saines K, Prescott WR, Ozcan A PloS one 23071544 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/23071544
Cellphone-based devices for bioanalytical sciences. Vashist SK, Mudanyali O, Schneider EM, Zengerle R, Ozcan A Analytical and bioanalytical chemistry 24287630 Anal Bioanal Chem 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24287630
Detection and spatial mapping of mercury contamination in water samples using a smart-phone. Wei Q, Nagi R, Sadeghi K, Feng S, Yan E, Ki SJ, Caire R, Tseng D, Ozcan A ACS nano 24437470 ACS Nano 2014 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/24437470
Fluorescent imaging of single nanoparticles and viruses on a smart phone. Wei Q, Qi H, Luo W, Tseng D, Ki SJ, Wan Z, Göröcs Z, Bentolila LA, Wu TT, Sun R, Ozcan A ACS nano 24016065 ACS Nano 2013 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/24016065
Cost-effective and compact wide-field fluorescent imaging on a cell-phone. Zhu H, Yaglidere O, Su TW, Tseng D, Ozcan A Lab on a chip 21063582 Lab Chip 2011 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/21063582
Immunochromatographic diagnostic test analysis using Google Glass. Feng S, Caire R, Cortazar B, Turan M, Wong A, Ozcan A ACS nano 24571349 ACS Nano 2014 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/24571349
Mobile phones democratize and cultivate next-generation imaging, diagnostics and measurement tools. Ozcan A Lab on a chip 24647550 Lab Chip 2014 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/24647550
Nano-imaging enabled via self-assembly. McLeod E, Ozcan A Nano today 25506387 Nano Today 2014 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/25506387
Organohalogen and organophosphorous pesticide method for ginseng root--a comparison of gas chromatography-single quadrupole mass spectrometry with high resolution time-of-flight mass spectrometry. Hayward DG, Wong JW Analytical chemistry 19548696 Anal Chem 2009 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/19548696
Multiresidue pesticide analysis in ginseng and spinach by nontargeted and targeted screening procedures. Hayward DG, Wong JW, Zhang K, Chang J, Shi F, Banerjee K, Yang P Journal of AOAC International 22320080 J AOAC Int 2011 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/22320080
RNA Chromatin Immunoprecipitation (RNA-ChIP) in Caenorhabditis elegans. Cecere G, Grishok A Bio-protocol 29170745 Bio Protoc 2014 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/29170745
The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A Molecular cell 23806335 Mol Cell 2013 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/23806335
CSR-1 RNAi pathway positively regulates histone expression in C. elegans. Avgousti DC, Palani S, Sherman Y, Grishok A The EMBO journal 22863779 EMBO J 2012 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/22863779
Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A Molecular cell 22819322 Mol Cell 2012 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/22819322
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Rational design and synthesis of freestanding photoelectric nanodevices as highly efficient photocatalysts. Qu Y, Liao L, Cheng R, Wang Y, Lin YC, Huang Y, Duan X Nano letters 20373781 Nano Lett 2010 May 12 https://www.ncbi.nlm.nih.gov/pubmed/20373781
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High-speed graphene transistors with a self-aligned nanowire gate. Liao L, Lin YC, Bao M, Cheng R, Bai J, Liu Y, Qu Y, Wang KL, Huang Y, Duan X Nature 20811365 Nature 2010 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/20811365
Sub-100 nm channel length graphene transistors. Liao L, Bai J, Cheng R, Lin YC, Jiang S, Qu Y, Huang Y, Duan X Nano letters 20815334 Nano Lett 2010 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/20815334
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Microfluidic-SERS devices for one shot limit-of-detection. Kim D, Campos AR, Datt A, Gao Z, Rycenga M, Burrows ND, Greeneltch NG, Mirkin CA, Murphy CJ, Van Duyne RP, Haynes CL The Analyst 24756225 Analyst 2014 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/24756225
Analytical characterization of the role of phospholipids in platelet adhesion and secretion. Koseoglu S, Meyer AF, Kim D, Meyer BM, Wang Y, Dalluge JJ, Haynes CL Analytical chemistry 25439269 Anal Chem 2015 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/25439269
Checkpoints for Preliminary Identification of Small Molecules found Enriched in Autophagosomes and Activated Mast Cell Secretions Analyzed by Comparative UPLC/MS(e). Satori CP, Ramezani M, Koopmeiners JS, Meyer AF, Rodriguez-Navarro JA, Kuhns MM, Taylor TH, Haynes CL, Dalluge JJ, Arriaga EA Analytical methods : advancing methods and applications 28194233 Anal Methods 2017 https://www.ncbi.nlm.nih.gov/pubmed/28194233
Cytoskeletal F-actin, not the circumferential coil of microtubules, regulates platelet dense-body granule secretion. Ge S, White JG, Haynes CL Platelets 21988315 Platelets 2012 https://www.ncbi.nlm.nih.gov/pubmed/21988315
Electroanalytical eavesdropping on single cell communication. Kim D, Koseoglu S, Manning BM, Meyer AF, Haynes CL Analytical chemistry 21766792 Anal Chem 2011 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/21766792
Neuropeptide-Induced Mast Cell Degranulation and Characterization of Signaling Modulation in Response to IgE Conditioning. Manning BM, Gruba SM, Meyer AF, Haynes CL ACS chemical biology 27580075 ACS Chem Biol 2016 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/27580075
Platelet membrane variations and their effects on δ-granule secretion kinetics and aggregation spreading among different species. Gruba SM, Koseoglu S, Meyer AF, Meyer BM, Maurer-Jones MA, Haynes CL Biochimica et biophysica acta 25906946 Biochim Biophys Acta 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25906946
Microfluidics-based in vivo mimetic systems for the study of cellular biology. Kim D, Wu X, Young AT, Haynes CL Accounts of chemical research 24555566 Acc Chem Res 2014 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/24555566
On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles. Kim D, Finkenstaedt-Quinn S, Hurley KR, Buchman JT, Haynes CL The Analyst 24300894 Analyst 2014 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/24300894
Critical role of membrane cholesterol in exocytosis revealed by single platelet study. Ge S, White JG, Haynes CL ACS chemical biology 20590163 ACS Chem Biol 2010 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/20590163
The role of p38 MAPK in neutrophil functions: single cell chemotaxis and surface marker expression. Kim D, Haynes CL The Analyst 24061073 Analyst 2013 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/24061073
Exploring inflammatory disease drug effects on neutrophil function. Wu X, Kim D, Young AT, Haynes CL The Analyst 24946254 Analyst 2014 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/24946254
Cytoskeleton dynamics in drug-treated platelets. Finkenstaedt-Quinn SA, Ge S, Haynes CL Analytical and bioanalytical chemistry 25701419 Anal Bioanal Chem 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25701419
Variations in Fusion Pore Formation in Cholesterol-Treated Platelets. Finkenstaedt-Quinn SA, Gruba SM, Haynes CL Biophysical journal 26910428 Biophys J 2016 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/26910428
Platelet Response to Allergens, CXCL10, and CXCL5 in the Context of Asthma. Gruba S, Wu X, Spanolios E, He J, Xiong-Hang K, Haynes CL ACS bio & med chem Au 36820311 ACS Bio Med Chem Au 2023 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/36820311
Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis. Koseoglu S, Dilks JR, Peters CG, Fitch-Tewfik JL, Fadel NA, Jasuja R, Italiano JE Jr, Haynes CL, Flaumenhaft R Arteriosclerosis, thrombosis, and vascular biology 23288151 Arterioscler Thromb Vasc Biol 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23288151
On-chip evaluation of shear stress effect on cytotoxicity of mesoporous silica nanoparticles. Kim D, Lin YS, Haynes CL Analytical chemistry 22032307 Anal Chem 2011 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/22032307
Neutrophil chemotaxis within a competing gradient of chemoattractants. Kim D, Haynes CL Analytical chemistry 22816782 Anal Chem 2012 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/22816782
On-chip evaluation of neutrophil activation and neutrophil-endothelial cell interaction during neutrophil chemotaxis. Kim D, Haynes CL Analytical chemistry 24127752 Anal Chem 2013 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/24127752
Time- and concentration-dependent effects of exogenous serotonin and inflammatory cytokines on mast cell function. Gruba SM, Meyer AF, Manning BM, Wang Y, Thompson JW, Dalluge JJ, Haynes CL ACS chemical biology 24304209 ACS Chem Biol 2014 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/24304209
Electrochemical measurement of endogenous serotonin release from human blood platelets. Ge S, Woo E, White JG, Haynes CL Analytical chemistry 21384903 Anal Chem 2011 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/21384903
Recent progress in SERS biosensing. Bantz KC, Meyer AF, Wittenberg NJ, Im H, Kurtuluş O, Lee SH, Lindquist NC, Oh SH, Haynes CL Physical chemistry chemical physics : PCCP 21509385 Phys Chem Chem Phys 2011 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/21509385
Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation. Ryan SO, Johnson JL, Cobb BA Journal of immunology (Baltimore, Md. : 1950) 23576679 J Immunol 2013 May 15 https://www.ncbi.nlm.nih.gov/pubmed/23576679
Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling. Lewis CJ, Cobb BA Journal of immunology (Baltimore, Md. : 1950) 20200279 J Immunol 2010 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/20200279
Glycobiology of immune responses. Rabinovich GA, van Kooyk Y, Cobb BA Annals of the New York Academy of Sciences 22524422 Ann N Y Acad Sci 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22524422
Myeloid glycosylation defects lead to a spontaneous common variable immunodeficiency-like condition with associated hemolytic anemia and antilymphocyte autoimmunity. Ryan SO, Abbott DW, Cobb BA Journal of immunology (Baltimore, Md. : 1950) 24795453 J Immunol 2014 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/24795453
Host glycans and antigen presentation. Ryan SO, Cobb BA Microbes and infection 22580092 Microbes Infect 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22580092
Glycoantigens induce human peripheral Tr1 cell differentiation with gut-homing specialization. Kreisman LS, Cobb BA The Journal of biological chemistry 21228275 J Biol Chem 2011 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/21228275
Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii. Young NM, Kreisman LS, Stupak J, MacLean LL, Cobb BA, Richards JC Glycobiology 21321054 Glycobiology 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21321054
Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation. Ramachandra L, Qu Y, Wang Y, Lewis CJ, Cobb BA, Takatsu K, Boom WH, Dubyak GR, Harding CV Infection and immunity 20837713 Infect Immun 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/20837713
B-cell-independent sialylation of IgG. Jones MB, Oswald DM, Joshi S, Whiteheart SW, Orlando R, Cobb BA Proceedings of the National Academy of Sciences of the United States of America 27303031 Proc Natl Acad Sci U S A 2016 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/27303031
Roles for major histocompatibility complex glycosylation in immune function. Ryan SO, Cobb BA Seminars in immunopathology 22461020 Semin Immunopathol 2012 May https://www.ncbi.nlm.nih.gov/pubmed/22461020
The regulatory power of glycans and their binding partners in immunity. Johnson JL, Jones MB, Ryan SO, Cobb BA Trends in immunology 23485517 Trends Immunol 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23485517
Interaction of the Capsular Polysaccharide A from Bacteroides fragilis with DC-SIGN on Human Dendritic Cells is Necessary for Its Processing and Presentation to T Cells. Bloem K, García-Vallejo JJ, Vuist IM, Cobb BA, van Vliet SJ, van Kooyk Y Frontiers in immunology 23653626 Front Immunol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23653626
Polysaccharide A from the capsule of Bacteroides fragilis induces clonal CD4+ T cell expansion. Johnson JL, Jones MB, Cobb BA The Journal of biological chemistry 25540199 J Biol Chem 2015 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/25540199
Infection, inflammation and host carbohydrates: a Glyco-Evasion Hypothesis. Kreisman LS, Cobb BA Glycobiology 22492234 Glycobiology 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22492234
Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation. Johnson JL, Jones MB, Cobb BA Glycobiology 25347992 Glycobiology 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25347992
Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation. Velez CD, Lewis CJ, Kasper DL, Cobb BA Immunology 18778282 Immunology 2009 May https://www.ncbi.nlm.nih.gov/pubmed/18778282
Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses. Ryan SO, Leal SM Jr, Abbott DW, Pearlman E, Cobb BA Glycobiology 24310166 Glycobiology 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24310166
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production. Lewis CJ, Cobb BA European journal of immunology 21630251 Eur J Immunol 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21630251
MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation. Ryan SO, Bonomo JA, Zhao F, Cobb BA The Journal of experimental medicine 21502329 J Exp Med 2011 May 9 https://www.ncbi.nlm.nih.gov/pubmed/21502329
Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive. Keung AJ, Dong M, Schaffer DV, Kumar S Scientific reports 23660869 Sci Rep 2013 https://www.ncbi.nlm.nih.gov/pubmed/23660869
Vinculin tension distributions of individual stress fibers within cell-matrix adhesions. Chang CW, Kumar S Journal of cell science 23687380 J Cell Sci 2013 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/23687380
Combining mechanical and optical approaches to dissect cellular mechanobiology. Sen S, Kumar S Journal of biomechanics 19819457 J Biomech 2010 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/19819457
Independent regulation of tumor cell migration by matrix stiffness and confinement. Pathak A, Kumar S Proceedings of the National Academy of Sciences of the United States of America 22689955 Proc Natl Acad Sci U S A 2012 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/22689955
Cell-matrix mechanobiology: applications to brain tumors and design of tissue engineering scaffolds. Kumar S Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 19964076 Annu Int Conf IEEE Eng Med Biol Soc 2009 https://www.ncbi.nlm.nih.gov/pubmed/19964076
Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues. Keung AJ, Kumar S, Schaffer DV Annual review of cell and developmental biology 20590452 Annu Rev Cell Dev Biol 2010 https://www.ncbi.nlm.nih.gov/pubmed/20590452
Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. Keung AJ, Asuri P, Kumar S, Schaffer DV Integrative biology : quantitative biosciences from nano to macro 22854634 Integr Biol (Camb) 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22854634
Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness. Pathak A, Kumar S Integrative biology : quantitative biosciences from nano to macro 21210057 Integr Biol (Camb) 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21210057
Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Tanner K, Boudreau A, Bissell MJ, Kumar S Biophysical journal 21044574 Biophys J 2010 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/21044574
Microtopographical assembly of cardiomyocytes. Patel AA, Desai TA, Kumar S Integrative biology : quantitative biosciences from nano to macro 21863181 Integr Biol (Camb) 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21863181
Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cells. Keung AJ, de Juan-Pardo EM, Schaffer DV, Kumar S Stem cells (Dayton, Ohio) 21956892 Stem Cells 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21956892
A genetic strategy for the dynamic and graded control of cell mechanics, motility, and matrix remodeling. MacKay JL, Keung AJ, Kumar S Biophysical journal 22325265 Biophys J 2012 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/22325265
A fluorescent peroxidase probe increases the sensitivity of commercial ELISAs by two orders of magnitude. Acharya AP, Nafisi PM, Gardner A, Mackay JL, Kundu K, Kumar S, Murthy N Chemical communications (Cambridge, England) 24071916 Chem Commun (Camb) 2013 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/24071916
Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling. Umesh V, Rape AD, Ulrich TA, Kumar S PloS one 25000176 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/25000176
Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion. Wong SY, Ulrich TA, Deleyrolle LP, MacKay JL, Lin JM, Martuscello RT, Jundi MA, Reynolds BA, Kumar S Cancer research 25634210 Cancer Res 2015 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/25634210
Cell-Matrix De-Adhesion Dynamics Reflect Contractile Mechanics. Sen S, Kumar S Cellular and molecular bioengineering 21297858 Cell Mol Bioeng 2009 Jun https://www.ncbi.nlm.nih.gov/pubmed/21297858
Measuring the elastic properties of living cells with atomic force microscopy indentation. Mackay JL, Kumar S Methods in molecular biology (Clifton, N.J.) 23027009 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23027009
Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Kumar S, Weaver VM Cancer metastasis reviews 19153673 Cancer Metastasis Rev 2009 Jun https://www.ncbi.nlm.nih.gov/pubmed/19153673
Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics. Chang CW, Kumar S Scientific reports 26336830 Sci Rep 2015 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/26336830
CD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motility. Kim Y, Kumar S Molecular cancer research : MCR 24962319 Mol Cancer Res 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24962319
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Ulrich TA, de Juan Pardo EM, Kumar S Cancer research 19435897 Cancer Res 2009 May 15 https://www.ncbi.nlm.nih.gov/pubmed/19435897
Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform. Ananthanarayanan B, Kim Y, Kumar S Biomaterials 21820737 Biomaterials 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21820737
From molecular signal activation to locomotion: an integrated, multiscale analysis of cell motility on defined matrices. Pathak A, Kumar S PloS one 21483802 PLoS One 2011 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/21483802
Microscale mechanisms of agarose-induced disruption of collagen remodeling. Ulrich TA, Lee TG, Shon HK, Moon DW, Kumar S Biomaterials 21575987 Biomaterials 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21575987
Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters. MacKay JL, Kumar S Integrative biology : quantitative biosciences from nano to macro 25044255 Integr Biol (Camb) 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25044255
A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces. Rape AD, Kumar S Biomaterials 25047626 Biomaterials 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25047626
Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices. Ulrich TA, Jain A, Tanner K, MacKay JL, Kumar S Biomaterials 19926126 Biomaterials 2010 Mar https://www.ncbi.nlm.nih.gov/pubmed/19926126
Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve. Gould RA, Yalcin HC, MacKay JL, Sauls K, Norris R, Kumar S, Butcher JT Current biology : CB 26725196 Curr Biol 2016 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/26725196
Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Pathak A, Kumar S Integrative biology : quantitative biosciences from nano to macro 23832051 Integr Biol (Camb) 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23832051
Contractility dominates adhesive ligand density in regulating cellular de-adhesion and retraction kinetics. Sen S, Ng WP, Kumar S Annals of biomedical engineering 21046466 Ann Biomed Eng 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21046466
Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression. Lam WA, Cao L, Umesh V, Keung AJ, Sen S, Kumar S Molecular cancer 20144241 Mol Cancer 2010 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/20144241
Contributions of talin-1 to glioma cell-matrix tensional homeostasis. Sen S, Ng WP, Kumar S Journal of the Royal Society, Interface 22158841 J R Soc Interface 2012 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/22158841
Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility. MacKay JL, Sood A, Kumar S Soft matter 24622945 Soft Matter 2014 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/24622945
Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces. Lee J, Chu BH, Sen S, Gupte A, Chancellor TJ, Chang CY, Ren F, Kumar S, Lele TP Biomedical microdevices 20830527 Biomed Microdevices 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/20830527
Biophysics and dynamics of natural and engineered stem cell microenvironments. Keung AJ, Healy KE, Kumar S, Schaffer DV Wiley interdisciplinary reviews. Systems biology and medicine 20836010 Wiley Interdiscip Rev Syst Biol Med 2010 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/20836010
Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. Sen S, Dong M, Kumar S PloS one 20037648 PLoS One 2009 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/20037648
Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Silva IA, Bai S, McLean K, Yang K, Griffith K, Thomas D, Ginestier C, Johnston C, Kueck A, Reynolds RK, Wicha MS, Buckanovich RJ Cancer research 21498635 Cancer Res 2011 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/21498635
EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Bai S, Ingram P, Chen YC, Deng N, Pearson A, Niknafs YS, O'Hayer P, Wang Y, Zhang ZY, Boscolo E, Bischoff J, Yoon E, Buckanovich RJ Cancer research 27803106 Cancer Res 2016 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/27803106
Metformin targets ovarian cancer stem cells in vitro and in vivo. Shank JJ, Yang K, Ghannam J, Cabrera L, Johnston CJ, Reynolds RK, Buckanovich RJ Gynecologic oncology 22864111 Gynecol Oncol 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22864111
A novel model for evaluating therapies targeting human tumor vasculature and human cancer stem-like cells. Burgos-Ojeda D, McLean K, Bai S, Pulaski H, Gong Y, Silva I, Skorecki K, Tzukerman M, Buckanovich RJ Cancer research 23576551 Cancer Res 2013 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/23576551
Ovarian cancer stem cell markers: prognostic and therapeutic implications. Burgos-Ojeda D, Rueda BR, Buckanovich RJ Cancer letters 22334034 Cancer Lett 2012 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/22334034
F3-targeted cisplatin-hydrogel nanoparticles as an effective therapeutic that targets both murine and human ovarian tumor endothelial cells in vivo. Winer I, Wang S, Lee YE, Fan W, Gong Y, Burgos-Ojeda D, Spahlinger G, Kopelman R, Buckanovich RJ Cancer research 20959470 Cancer Res 2010 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/20959470
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Apostolou E, Ferrari F, Walsh RM, Bar-Nur O, Stadtfeld M, Cheloufi S, Stuart HT, Polo JM, Ohsumi TK, Borowsky ML, Kharchenko PV, Park PJ, Hochedlinger K Cell stem cell 23665121 Cell Stem Cell 2013 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/23665121
A high-efficiency system for the generation and study of human induced pluripotent stem cells. Maherali N, Ahfeldt T, Rigamonti A, Utikal J, Cowan C, Hochedlinger K Cell stem cell 18786420 Cell Stem Cell 2008 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/18786420
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Maherali N, Sridharan R, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld M, Yachechko R, Tchieu J, Jaenisch R, Plath K, Hochedlinger K Cell stem cell 18371336 Cell Stem Cell 2007 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/18371336
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K Nature 19668190 Nature 2009 Aug 27 https://www.ncbi.nlm.nih.gov/pubmed/19668190
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Hirata A, Utikal J, Yamashita S, Aoki H, Watanabe A, Yamamoto T, Okano H, Bardeesy N, Kunisada T, Ushijima T, Hara A, Jaenisch R, Hochedlinger K, Yamada Y Development (Cambridge, England) 23222438 Development 2013 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/23222438
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Stadtfeld M, Brennand K, Hochedlinger K Current biology : CB 18501604 Curr Biol 2008 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/18501604
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G Stem cells (Dayton, Ohio) 19096035 Stem Cells 2009 Mar https://www.ncbi.nlm.nih.gov/pubmed/19096035
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K Cell stem cell 21982232 Cell Stem Cell 2011 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/21982232
Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Maherali N, Hochedlinger K Current biology : CB 19765992 Curr Biol 2009 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/19765992
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K Nature genetics 19668214 Nat Genet 2009 Sep https://www.ncbi.nlm.nih.gov/pubmed/19668214
Anti-DNA:RNA antibodies and silicon photonic microring resonators: increased sensitivity for multiplexed microRNA detection. Qavi AJ, Kindt JT, Gleeson MA, Bailey RC Analytical chemistry 21711056 Anal Chem 2011 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/21711056
Research Spotlight: New multiparameter bioanalytical technologies for applications in personalized medicine, drug discovery and fundamental biology. Bailey RC Bioanalysis 21083072 Bioanalysis 2009 Sep https://www.ncbi.nlm.nih.gov/pubmed/21083072
Multiplexed evaluation of capture agent binding kinetics using arrays of silicon photonic microring resonators. Byeon JY, Bailey RC The Analyst 21085731 Analyst 2011 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/21085731
Magnetically-actuated, bead-enhanced silicon photonic immunosensor. Valera E, McClellan MS, Bailey RC Analytical methods : advancing methods and applications 26528374 Anal Methods 2015 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/26528374
Subpicogram per milliliter detection of interleukins using silicon photonic microring resonators and an enzymatic signal enhancement strategy. Kindt JT, Luchansky MS, Qavi AJ, Lee SH, Bailey RC Analytical chemistry 24171505 Anal Chem 2013 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/24171505
Label-free virus detection using silicon photonic microring resonators. McClellan MS, Domier LL, Bailey RC Biosensors & bioelectronics 22138465 Biosens Bioelectron 2012 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/22138465
Label-free technologies for quantitative multiparameter biological analysis. Qavi AJ, Washburn AL, Byeon JY, Bailey RC Analytical and bioanalytical chemistry 19221722 Anal Bioanal Chem 2009 May https://www.ncbi.nlm.nih.gov/pubmed/19221722
Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators. Washburn AL, Gunn LC, Bailey RC Analytical chemistry 19848413 Anal Chem 2009 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/19848413
Efficient bioconjugation of protein capture agents to biosensor surfaces using aniline-catalyzed hydrazone ligation. Byeon JY, Limpoco FT, Bailey RC Langmuir : the ACS journal of surfaces and colloids 20809595 Langmuir 2010 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/20809595
Characterization of the evanescent field profile and bound mass sensitivity of a label-free silicon photonic microring resonator biosensing platform. Luchansky MS, Washburn AL, Martin TA, Iqbal M, Gunn LC, Bailey RC Biosensors & bioelectronics 20708399 Biosens Bioelectron 2010 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/20708399
Isothermal discrimination of single-nucleotide polymorphisms via real-time kinetic desorption and label-free detection of DNA using silicon photonic microring resonator arrays. Qavi AJ, Mysz TM, Bailey RC Analytical chemistry 21834517 Anal Chem 2011 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/21834517
Grand challenge commentary: Informative diagnostics for personalized medicine. Bailey RC Nature chemical biology 21079587 Nat Chem Biol 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/21079587
Photonics-on-a-chip: recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications. Washburn AL, Bailey RC The Analyst 20957245 Analyst 2011 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/20957245
Nonlinear analyte concentration gradients for one-step kinetic analysis employing optical microring resonators. Marty MT, Sloan CD, Bailey RC, Sligar SG Analytical chemistry 22686186 Anal Chem 2012 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/22686186
Multiplexed detection and label-free quantitation of microRNAs using arrays of silicon photonic microring resonators. Qavi AJ, Bailey RC Angewandte Chemie (International ed. in English) 20491114 Angew Chem Int Ed Engl 2010 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/20491114
Silicon photonic microring resonators for quantitative cytokine detection and T-cell secretion analysis. Luchansky MS, Bailey RC Analytical chemistry 20143780 Anal Chem 2010 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/20143780
Quantitative, label-free detection of five protein biomarkers using multiplexed arrays of silicon photonic microring resonators. Washburn AL, Luchansky MS, Bowman AL, Bailey RC Analytical chemistry 20000326 Anal Chem 2010 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/20000326
Multiplexed cancer biomarker detection using chip-integrated silicon photonic sensor arrays. Washburn AL, Shia WW, Lenkeit KA, Lee SH, Bailey RC The Analyst 27400767 Analyst 2016 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/27400767
Single domain antibodies for the detection of ricin using silicon photonic microring resonator arrays. Shia WW, Bailey RC Analytical chemistry 23268548 Anal Chem 2013 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/23268548
High-Q optical sensors for chemical and biological analysis. Luchansky MS, Bailey RC Analytical chemistry 22111937 Anal Chem 2012 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/22111937
Real-time monitoring of surface-initiated atom transfer radical polymerization using silicon photonic microring resonators: implications for combinatorial screening of polymer brush growth conditions. Limpoco FT, Bailey RC Journal of the American Chemical Society 21899288 J Am Chem Soc 2011 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/21899288
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Associations Between Brain Metabolites Measured With MR Spectroscopy and Head Impacts in High School American Football Athletes. Liu Z, Dudley JA, Diekfuss JA, Ahmed N, Edmondson AD, Cecil KM, Yuan W, Zuleger TM, Slutsky-Ganesh AB, Barber Foss KD, Myer GD, Fleischer CC Journal of magnetic resonance imaging : JMRI 39177233 J Magn Reson Imaging 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/39177233
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Estimating muscle activation from EMG using deep learning-based dynamical systems models. Wimalasena LN, Braun JF, Keshtkaran MR, Hofmann D, Gallego JÁ, Alessandro C, Tresch MC, Miller LE, Pandarinath C Journal of neural engineering 35366649 J Neural Eng 2022 May 19 https://www.ncbi.nlm.nih.gov/pubmed/35366649
Reducing power requirements for high-accuracy decoding in iBCIs. Karpowicz BM, Bhaduri B, Nason-Tomaszewski SR, Jacques BG, Ali YH, Flint RD, Bechefsky PH, Hochberg LR, AuYong N, Slutzky MW, Pandarinath C Journal of neural engineering 39423832 J Neural Eng 2024 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/39423832
Pseudo-linear summation explains neural geometry of multi-finger movements in human premotor cortex. Shah NP, Avansino D, Kamdar F, Nicolas C, Kapitonava A, Vargas-Irwin C, Hochberg LR, Pandarinath C, Shenoy KV, Willett FR, Henderson JM Nature communications 40442062 Nat Commun 2025 May 30 https://www.ncbi.nlm.nih.gov/pubmed/40442062
A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution. Zhu F, Grier HA, Tandon R, Cai C, Agarwal A, Giovannucci A, Kaufman MT, Pandarinath C Nature neuroscience 36424431 Nat Neurosci 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36424431
Expressive dynamics models with nonlinear injective readouts enable reliable recovery of latent features from neural activity. Versteeg C, Sedler AR, McCart JD, Pandarinath C ArXiv 37744459 ArXiv 2023 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/37744459
Computation-through-Dynamics Benchmark: Simulated datasets and quality metrics for dynamical models of neural activity. Versteeg C, McCart JD, Ostrow M, Zoltowski DM, Washington CB, Driscoll L, Codol O, Michaels JA, Linderman SW, Sussillo D, Pandarinath C bioRxiv : the preprint server for biology 39975240 bioRxiv 2025 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/39975240
Expressive architectures enhance interpretability of dynamics-based neural population models. Sedler AR, Versteeg C, Pandarinath C Neurons, behavior, data analysis, and theory 38699512 Neuron Behav Data Anal Theory 2023 https://www.ncbi.nlm.nih.gov/pubmed/38699512
Identifying Distinct Neural Features between the Initial and Corrective Phases of Precise Reaching Using AutoLFADS. Lee WH, Karpowicz BM, Pandarinath C, Rouse AG The Journal of neuroscience : the official journal of the Society for Neuroscience 38538142 J Neurosci 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/38538142
Spinal interneuron population dynamics underlying flexible pattern generation. Wimalasena LN, Pandarinath C, Yong NA bioRxiv : the preprint server for biology 38948833 bioRxiv 2024 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/38948833
Myomatrix arrays for high-definition muscle recording. Chung B, Zia M, Thomas KA, Michaels JA, Jacob A, Pack A, Williams MJ, Nagapudi K, Teng LH, Arrambide E, Ouellette L, Oey N, Gibbs R, Anschutz P, Lu J, Wu Y, Kashefi M, Oya T, Kersten R, Mosberger AC, O'Connell S, Wang R, Marques H, Mendes AR, Lenschow C, Kondakath G, Kim JJ, Olson W, Quinn KN, Perkins P, Gatto G, Thanawalla A, Coltman S, Kim T, Smith T, Binder-Markey B, Zaback M, Thompson CK, Giszter S, Person A, Goulding M, Azim E, Thakor N, O'Connor D, Trimmer B, Lima SQ, Carey MR, Pandarinath C, Costa RM, Pruszynski JA, Bakir M, Sober SJ eLife 38113081 Elife 2023 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/38113081
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Stabilizing brain-computer interfaces through alignment of latent dynamics. Karpowicz BM, Ali YH, Wimalasena LN, Sedler AR, Keshtkaran MR, Bodkin K, Ma X, Rubin DB, Williams ZM, Cash SS, Hochberg LR, Miller LE, Pandarinath C Nature communications 40389429 Nat Commun 2025 May 19 https://www.ncbi.nlm.nih.gov/pubmed/40389429
Diffusion-Based Generation of Neural Activity from Disentangled Latent Codes. McCart JD, Sedler AR, Versteeg C, Mifsud D, Rigotti-Thompson M, Pandarinath C ArXiv 39130199 ArXiv 2024 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/39130199
A large-scale neural network training framework for generalized estimation of single-trial population dynamics. Keshtkaran MR, Sedler AR, Chowdhury RH, Tandon R, Basrai D, Nguyen SL, Sohn H, Jazayeri M, Miller LE, Pandarinath C Nature methods 36443486 Nat Methods 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36443486
High-performance neural population dynamics modeling enabled by scalable computational infrastructure. Patel AN, Sedler AR, Huang J, Pandarinath C, Gilja V Journal of open source software 37520691 J Open Source Softw 2023 https://www.ncbi.nlm.nih.gov/pubmed/37520691
A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes. Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo VK, Chiu I, Ginty DD, Sharma N bioRxiv : the preprint server for biology 37131664 bioRxiv 2023 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/37131664
Activity-dependent development of the body's touch receptors. Santiago C, Siegrist J, Africawala N, Handler A, Tasnim A, Anjum R, Turecek J, Lehnert BP, Renauld S, Choi J, Nolan-Tamariz M, Iskols M, Magee AR, Paradis S, Sharma N, Ginty DD Neuron 40381613 Neuron 2025 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/40381613
A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo VK, Chiu IM, Ginty DD, Sharma N Cell 38442711 Cell 2024 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/38442711
DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi S, Sharma N, Ginty DD Cell 37541195 Cell 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37541195
Activity-dependent development of the body's touch receptors. Santiago C, Sharma N, Africawala N, Siegrist J, Handler A, Tasnim A, Anjum R, Turecek J, Lehnert BP, Renauld S, Nolan-Tamariz M, Iskols M, Magee AR, Paradis S, Ginty DD bioRxiv : the preprint server for biology 37790437 bioRxiv 2023 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/37790437
Zebrafish: an underutilized tool for discovery in host-microbe interactions. Stream A, Madigan CA Trends in immunology 35527182 Trends Immunol 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35527182
Magnetic Detection of Neural Activity by Nanocoil Transducers. Bok I, Phillips J, Zhu T, Lu J, Detienne E, Lima EA, Weiss BP, Jasanoff A, Hai A Nano letters 39319575 Nano Lett 2024 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/39319575
Wireless in vivo Recording of Cortical Activity by an Ion-Sensitive Field Effect Transistor. Bhatt S, Masterson E, Zhu T, Eizadi J, George J, Graupe N, Vareberg A, Phillips J, Bok I, Dwyer M, Ashtiani A, Hai A Sensors and actuators. B, Chemical 36970106 Sens Actuators B Chem 2023 May 1 https://www.ncbi.nlm.nih.gov/pubmed/36970106
Stimulation-mediated reverse engineering of silent neural networks. Ren X, Bok I, Vareberg A, Hai A Journal of neurophysiology 37222450 J Neurophysiol 2023 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/37222450
Inference of network connectivity from temporally binned spike trains. Vareberg AD, Bok I, Eizadi J, Ren X, Hai A Journal of neuroscience methods 38309313 J Neurosci Methods 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38309313
In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles. Bok I, Haber I, Qu X, Hai A Scientific reports 35589877 Sci Rep 2022 May 19 https://www.ncbi.nlm.nih.gov/pubmed/35589877
Enhanced magnetic transduction of neuronal activity by nanofabricated inductors quantified via finite element analysis. Phillips J, Glodowski M, Gokhale Y, Dwyer M, Ashtiani A, Hai A Journal of neural engineering 35705065 J Neural Eng 2022 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/35705065
Self-Aligned Multilayered Nitrogen Vacancy Diamond Nanoparticles for High Spatial Resolution Magnetometry of Microelectronic Currents. Gokhale Y, Coventry BS, Rogers T, Lines M, Vena A, Phillips J, Zhu T, Bok I, Troche D, Glodowski M, Vareberg A, Bhatt S, Ashtiani AO, Eliceiri KW, Hai A Nano letters 40387807 Nano Lett 2025 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/40387807
Direct observation of NMR transverse relaxation in nanopatterned clusters of iron oxide particles. Bok I, Rauch B, Ashtiani A, Hai A Magnetic resonance in medicine 37867452 Magn Reson Med 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37867452
Wireless in vivo Recording of Cortical Activity by an Ion-Sensitive Field Effect Transistor. Bhatt S, Masterson E, Zhu T, Eizadi J, George J, Graupe N, Vareberg A, Phillips J, Bok I, Dwyer M, Ashtiani A, Hai A bioRxiv : the preprint server for biology 36711824 bioRxiv 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36711824
Wireless agents for brain recording and stimulation modalities. Bok I, Vareberg A, Gokhale Y, Bhatt S, Masterson E, Phillips J, Zhu T, Ren X, Hai A Bioelectronic medicine 37726851 Bioelectron Med 2023 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/37726851
Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence. Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC The Journal of neuroscience : the official journal of the Society for Neuroscience 33637558 J Neurosci 2021 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/33637558
Implications of Extended Inhibitory Neuron Development. Kim JY, Paredes MF International journal of molecular sciences 34066025 Int J Mol Sci 2021 May 12 https://www.ncbi.nlm.nih.gov/pubmed/34066025
Amplification of human interneuron progenitors promotes brain tumors and neurological defects. Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA Science (New York, N.Y.) 35084981 Science 2022 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/35084981
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Nicotinic acetylcholine signaling is required for motor learning but not for rehabilitation from spinal cord injury. Li Y, Hollis Ii ER Neural regeneration research 35900431 Neural Regen Res 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/35900431
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Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Ren W, Medeiros N, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K Nature communications 32376827 Nat Commun 2020 May 6 https://www.ncbi.nlm.nih.gov/pubmed/32376827
Targeted Nuclease Approaches for Mapping Native R-Loops. Wulfridge P, Yan Q, Sarma K Methods in molecular biology (Clifton, N.J.) 35704205 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35704205
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R Nature communications 34493732 Nat Commun 2021 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/34493732
Targeted Enhancer Activation by a Subunit of the Integrator Complex. Barbieri E, Trizzino M, Welsh SA, Owens TA, Calabretta B, Carroll M, Sarma K, Gardini A Molecular cell 30008316 Mol Cell 2018 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/30008316
Proximity labeling identifies a repertoire of site-specific R-loop modulators. Yan Q, Wulfridge P, Doherty J, Fernandez-Luna JL, Real PJ, Tang HY, Sarma K Nature communications 35013239 Nat Commun 2022 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/35013239
SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia. Han C, Khodadadi-Jamayran A, Lorch AH, Jin Q, Serafin V, Zhu P, Politanska Y, Sun L, Gutierrez-Diaz BT, Pryzhkova MV, Abdala-Valencia H, Bartom ET, Buldini B, Basso G, Velu SE, Sarma K, Mattamana BB, Cho BK, Obeng RC, Goo YA, Jordan PW, Tsirigos A, Zhou Y, Ntziachristos P Science advances 35061527 Sci Adv 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/35061527
ATRX histone binding and helicase activities have distinct roles in neuronal differentiation. Bieluszewska A, Wulfridge P, Doherty J, Ren W, Sarma K Nucleic acids research 35998910 Nucleic Acids Res 2022 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/35998910
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures. Shukla V, Samaniego-Castruita D, Dong Z, González-Avalos E, Yan Q, Sarma K, Rao A Nature immunology 34937926 Nat Immunol 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34937926
A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide. Wulfridge P, Sarma K eLife 33620319 Elife 2021 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/33620319
MapR: A Method for Identifying Native R-Loops Genome Wide. Yan Q, Sarma K Current protocols in molecular biology 31943854 Curr Protoc Mol Biol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31943854
Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach. Yan Q, Shields EJ, Bonasio R, Sarma K Cell reports 31665646 Cell Rep 2019 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/31665646
G-quadruplexes associated with R-loops promote CTCF binding. Wulfridge P, Yan Q, Rell N, Doherty J, Jacobson S, Offley S, Deliard S, Feng K, Phillips-Cremins JE, Gardini A, Sarma K Molecular cell 37552993 Mol Cell 2023 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/37552993
Modulation of tactile feedback for the execution of dexterous movement. Conner JM, Bohannon A, Igarashi M, Taniguchi J, Baltar N, Azim E Science (New York, N.Y.) 34648327 Science 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34648327
Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity. Lustig J, Lammers A, Kaiser J, Patel P, Raghu A, Conner JM, Nguyen P, Azim E, Sahni V bioRxiv : the preprint server for biology 39713479 bioRxiv 2024 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/39713479
Gain control in the sensorimotor system. Azim E, Seki K Current opinion in physiology 31403088 Curr Opin Physiol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/31403088
Anipose: A toolkit for robust markerless 3D pose estimation. Karashchuk P, Rupp KL, Dickinson ES, Walling-Bell S, Sanders E, Azim E, Brunton BW, Tuthill JC Cell reports 34592148 Cell Rep 2021 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/34592148
Reverse-translational identification of a cerebellar satiation network. Low AYT, Goldstein N, Gaunt JR, Huang KP, Zainolabidin N, Yip AKK, Carty JRE, Choi JY, Miller AM, Ho HST, Lenherr C, Baltar N, Azim E, Sessions OM, Ch'ng TH, Bruce AS, Martin LE, Halko MA, Brady RO Jr, Holsen LM, Alhadeff AL, Chen AI, Betley JN Nature 34789878 Nature 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34789878
The Cerebellar Nuclei and Dexterous Limb Movements. Thanawalla AR, Chen AI, Azim E Neuroscience 32652173 Neuroscience 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/32652173
Proprioception. Tuthill JC, Azim E Current biology : CB 29510103 Curr Biol 2018 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/29510103
Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models. Butler DJ, Keim AP, Ray S, Azim E Nature communications 37752123 Nat Commun 2023 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/37752123
The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states. Upadhyay A, Gradwell MA, Vajtay TJ, Conner J, Sanyal AA, Azadegan C, Patel KR, Thackray JK, Bohic M, Imai F, Ogundare SO, Yoshida Y, Abdus-Saboor I, Azim E, Abraira VE Cell reports 40202848 Cell Rep 2025 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/40202848
Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice. Kim J, Erskine A, Cheung JA, Hires SA Neuron 33002411 Neuron 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33002411
Dynamic cues for whisker-based object localization: An analytical solution to vibration during active whisker touch. Vaxenburg R, Wyche I, Svoboda K, Efros AL, Hires SA PLoS computational biology 29584719 PLoS Comput Biol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29584719
The Sensorimotor Basis of Whisker-Guided Anteroposterior Object Localization in Head-Fixed Mice. Cheung J, Maire P, Kim J, Sy J, Hires SA Current biology : CB 31474537 Curr Biol 2019 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/31474537
Posterior amygdala regulates sexual and aggressive behaviors in male mice. Yamaguchi T, Wei D, Song SC, Lim B, Tritsch NX, Lin D Nature neuroscience 32719562 Nat Neurosci 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32719562
Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake. Melani R, Tritsch NX Cell reports 35443174 Cell Rep 2022 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/35443174
Unraveling the dynamics of dopamine release and its actions on target cells. Sippy T, Tritsch NX Trends in neurosciences 36635111 Trends Neurosci 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36635111
GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABA(A) receptors. Patel JC, Sherpa AD, Melani R, Witkovsky P, Wiseman MR, O'Neill B, Aoki C, Tritsch NX, Rice ME Cell reports 38431842 Cell Rep 2024 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/38431842
A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors. Fang YY, Yamaguchi T, Song SC, Tritsch NX, Lin D Neuron 29621487 Neuron 2018 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/29621487
Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice. Longo F, Aryal S, Anastasiades PG, Maltese M, Baimel C, Albanese F, Tabor J, Zhu JD, Oliveira MM, Gastaldo D, Bagni C, Santini E, Tritsch NX, Carter AG, Klann E Cell reports 37505982 Cell Rep 2023 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/37505982
Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum. Maltese M, March JR, Bashaw AG, Tritsch NX eLife 33983121 Elife 2021 May 13 https://www.ncbi.nlm.nih.gov/pubmed/33983121
Intrinsic dopamine and acetylcholine dynamics in the striatum of mice. Krok AC, Maltese M, Mistry P, Miao X, Li Y, Tritsch NX Nature 37558873 Nature 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37558873
Acetylcholine waves and dopamine release in the striatum. Matityahu L, Gilin N, Sarpong GA, Atamna Y, Tiroshi L, Tritsch NX, Wickens JR, Goldberg JA Nature communications 37891198 Nat Commun 2023 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/37891198
G protein-coupled receptors cooperate to silence dopamine neurons. Liu H, Tritsch NX The Journal of physiology 36214545 J Physiol 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36214545
Nongenetic Optical Methods for Measuring and Modulating Neuronal Response. Zimmerman JF, Tian B ACS nano 29727159 ACS Nano 2018 May 22 https://www.ncbi.nlm.nih.gov/pubmed/29727159
Texturing Silicon Nanowires for Highly Localized Optical Modulation of Cellular Dynamics. Fang Y, Jiang Y, Acaron Ledesma H, Yi J, Gao X, Weiss DE, Shi F, Tian B Nano letters 29894630 Nano Lett 2018 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/29894630
Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires. Parameswaran R, Carvalho-de-Souza JL, Jiang Y, Burke MJ, Zimmerman JF, Koehler K, Phillips AW, Yi J, Adams EJ, Bezanilla F, Tian B Nature nanotechnology 29459654 Nat Nanotechnol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29459654
Alloy-assisted deposition of three-dimensional arrays of atomic gold catalyst for crystal growth studies. Fang Y, Jiang Y, Cherukara MJ, Shi F, Koehler K, Freyermuth G, Isheim D, Narayanan B, Nicholls AW, Seidman DN, Sankaranarayanan SKRS, Tian B Nature communications 29222439 Nat Commun 2017 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/29222439
Silicon Nanowires for Intracellular Optical Interrogation with Subcellular Resolution. Rotenberg MY, Elbaz B, Nair V, Schaumann EN, Yamamoto N, Sarma N, Matino L, Santoro F, Tian B Nano letters 31904975 Nano Lett 2020 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/31904975
Nanowired Bioelectric Interfaces. Tian B, Lieber CM Chemical reviews 30995019 Chem Rev 2019 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/30995019
Soft-Hard Composites for Bioelectric Interfaces. Lin Y, Fang Y, Yue J, Tian B Trends in chemistry 34296076 Trends Chem 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/34296076
Biological Interfaces, Modulation, and Sensing with Inorganic Nano-Bioelectronic Materials. Schaumann EN, Tian B Small methods 34295965 Small Methods 2020 May 11 https://www.ncbi.nlm.nih.gov/pubmed/34295965
Talking to cells: semiconductor nanomaterials at the cellular interface. Rotenberg MY, Tian B Advanced biosystems 30906852 Adv Biosyst 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/30906852
Inorganic semiconductor biointerfaces. Jiang Y, Tian B Nature reviews. Materials 31656635 Nat Rev Mater 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/31656635
Recent advances in bioelectronics chemistry. Fang Y , Meng L , Prominski A , Schaumann EN , Seebald M , Tian B Chemical Society reviews 32672777 Chem Soc Rev 2020 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/32672777
Laser writing of nitrogen-doped silicon carbide for biological modulation. Nair V, Yi J, Isheim D, Rotenberg M, Meng L, Shi F, Chen X, Gao X, Prominski A, Jiang Y, Yue J, Gallagher CT, Seidman DN, Tian B Science advances 32937377 Sci Adv 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32937377
Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix. Parameswaran R, Koehler K, Rotenberg MY, Burke MJ, Kim J, Jeong KY, Hissa B, Paul MD, Moreno K, Sarma N, Hayes T, Sudzilovsky E, Park HG, Tian B Proceedings of the National Academy of Sciences of the United States of America 30538202 Proc Natl Acad Sci U S A 2019 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/30538202
An atlas of nano-enabled neural interfaces. Acarón Ledesma H, Li X, Carvalho-de-Souza JL, Wei W, Bezanilla F, Tian B Nature nanotechnology 31270446 Nat Nanotechnol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31270446
Rational design of silicon structures for optically controlled multiscale biointerfaces. Jiang Y, Li X, Liu B, Yi J, Fang Y, Shi F, Gao X, Sudzilovsky E, Parameswaran R, Koehler K, Nair V, Yue J, Guo K, Fang Y, Tsai HM, Freyermuth G, Wong RCS, Kao CM, Chen CT, Nicholls AW, Wu X, Shepherd GMG, Tian B Nature biomedical engineering 30906646 Nat Biomed Eng 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/30906646
Nongenetic optical neuromodulation with silicon-based materials. Jiang Y, Parameswaran R, Li X, Carvalho-de-Souza JL, Gao X, Meng L, Bezanilla F, Shepherd GMG, Tian B Nature protocols 30980031 Nat Protoc 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30980031
Dissecting Biological and Synthetic Soft-Hard Interfaces for Tissue-Like Systems. Fang Y, Yang X, Lin Y, Shi J, Prominski A, Clayton C, Ostroff E, Tian B Chemical reviews 34677943 Chem Rev 2022 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/34677943
Nano-enabled cellular engineering for bioelectric studies. Shi J, Clayton C, Tian B Nano research 34295455 Nano Res 2020 May https://www.ncbi.nlm.nih.gov/pubmed/34295455
Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. Lee YV, Wu D, Fang Y, Peng Y, Tian B Nano letters 32208712 Nano Lett 2020 May 13 https://www.ncbi.nlm.nih.gov/pubmed/32208712
Living myofibroblast-silicon composites for probing electrical coupling in cardiac systems. Rotenberg MY, Yamamoto N, Schaumann EN, Matino L, Santoro F, Tian B Proceedings of the National Academy of Sciences of the United States of America 31624124 Proc Natl Acad Sci U S A 2019 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/31624124
Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces. Fang Y, Prominski A, Rotenberg MY, Meng L, Acarón Ledesma H, Lv Y, Yue J, Schaumann E, Jeong J, Yamamoto N, Jiang Y, Elbaz B, Wei W, Tian B Nature nanotechnology 33288948 Nat Nanotechnol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33288948
Biomimetic Approaches Toward Smart Bio-hybrid Systems. Luo Z, Weiss DE, Liu Q, Tian B Nano research 30906509 Nano Res 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/30906509
Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation. Lee YV, Tian B Nano letters 30888185 Nano Lett 2019 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/30888185
Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons. Campbell EP, Abushawish AA, Valdez LA, Bell MK, Haryono M, Rangamani P, Bloodgood BL Cell reports 36640310 Cell Rep 2023 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/36640310
Sensorimotor Transformations Underlying Variability in Song Intensity during Drosophila Courtship. Coen P, Xie M, Clemens J, Murthy M Neuron 26844835 Neuron 2016 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/26844835
Neural network organization for courtship-song feature detection in Drosophila. Baker CA, McKellar C, Pang R, Nern A, Dorkenwald S, Pacheco DA, Eckstein N, Funke J, Dickson BJ, Murthy M Current biology : CB 35793679 Curr Biol 2022 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/35793679
Fast intensity adaptation enhances the encoding of sound in Drosophila. Clemens J, Ozeri-Engelhard N, Murthy M Nature communications 29317624 Nat Commun 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29317624
Acoustic Pattern Recognition and Courtship Songs: Insights from Insects. Baker CA, Clemens J, Murthy M Annual review of neuroscience 30786225 Annu Rev Neurosci 2019 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/30786225
Quantifying behavior to solve sensorimotor transformations: advances from worms and flies. Calhoun AJ, Murthy M Current opinion in neurobiology 28850885 Curr Opin Neurobiol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28850885
Experimental and statistical reevaluation provides no evidence for Drosophila courtship song rhythms. Stern DL, Clemens J, Coen P, Calhoun AJ, Hogenesch JB, Arthur BJ, Murthy M Proceedings of the National Academy of Sciences of the United States of America 28851830 Proc Natl Acad Sci U S A 2017 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/28851830
Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors. Deutsch D, Clemens J, Thiberge SY, Guan G, Murthy M Current biology : CB 31564492 Curr Biol 2019 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/31564492
Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Crocker A, Guan XJ, Murphy CT, Murthy M Cell reports 27160913 Cell Rep 2016 May 17 https://www.ncbi.nlm.nih.gov/pubmed/27160913
Connecting Neural Codes with Behavior in the Auditory System of Drosophila. Clemens J, Girardin CC, Coen P, Guan XJ, Dickson BJ, Murthy M Neuron 26365767 Neuron 2015 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/26365767
Discovery of a New Song Mode in Drosophila Reveals Hidden Structure in the Sensory and Neural Drivers of Behavior. Clemens J, Coen P, Roemschied FA, Pereira TD, Mazumder D, Aldarondo DE, Pacheco DA, Murthy M Current biology : CB 30057309 Curr Biol 2018 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/30057309
Singing on the fly: sensorimotor integration and acoustic communication in Drosophila. Coen P, Murthy M Current opinion in neurobiology 26874218 Curr Opin Neurobiol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26874218
Auditory activity is diverse and widespread throughout the central brain of Drosophila. Pacheco DA, Thiberge SY, Pnevmatikakis E, Murthy M Nature neuroscience 33230320 Nat Neurosci 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33230320
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V Nature biotechnology 26829320 Nat Biotechnol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26829320
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons. Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V Nature communications 25222271 Nat Commun 2014 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/25222271
Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping. Treweek JB, Chan KY, Flytzanis NC, Yang B, Deverman BE, Greenbaum A, Lignell A, Xiao C, Cai L, Ladinsky MS, Bjorkman PJ, Fowlkes CC, Gradinaru V Nature protocols 26492141 Nat Protoc 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26492141
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset. Goertsen D, Flytzanis NC, Goeden N, Chuapoco MR, Cummins A, Chen Y, Fan Y, Zhang Q, Sharma J, Duan Y, Wang L, Feng G, Chen Y, Ip NY, Pickel J, Gradinaru V Nature neuroscience 34887588 Nat Neurosci 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34887588
Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology? Greenbaum A, Jang MJ, Challis C, Gradinaru V BMC biology 28946882 BMC Biol 2017 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/28946882
Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research. Robinson JE, Gradinaru V Current opinion in neurobiology 28850815 Curr Opin Neurobiol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/28850815
Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways. Xiao C, Cho JR, Zhou C, Treweek JB, Chan K, McKinney SL, Yang B, Gradinaru V Neuron 27100197 Neuron 2016 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/27100197
The Jellyfish Cassiopea Exhibits a Sleep-like State. Nath RD, Bedbrook CN, Abrams MJ, Basinger T, Bois JS, Prober DA, Sternberg PW, Gradinaru V, Goentoro L Current biology : CB 28943083 Curr Biol 2017 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/28943083
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V Nature neuroscience 28671695 Nat Neurosci 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28671695
Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, Deverman BE, Münzberg H, Ardell JL, Salama G, Gradinaru V, Shivkumar K Nature communications 31028266 Nat Commun 2019 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/31028266
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types. Ravindra Kumar S, Miles TF, Chen X, Brown D, Dobreva T, Huang Q, Ding X, Luo Y, Einarsson PH, Greenbaum A, Jang MJ, Deverman BE, Gradinaru V Nature methods 32313222 Nat Methods 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32313222
Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery. Smith EJ, Farshim PP, Flomen R, Jones ST, McAteer SJ, Deverman BE, Gradinaru V, Bates GP Brain communications 34131644 Brain Commun 2021 https://www.ncbi.nlm.nih.gov/pubmed/34131644
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics. Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH Nature methods 31611694 Nat Methods 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31611694
Directed evolution of a far-red fluorescent rhodopsin. McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH Proceedings of the National Academy of Sciences of the United States of America 25157169 Proc Natl Acad Sci U S A 2014 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/25157169
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Challis C, Hori A, Sampson TR, Yoo BB, Challis RC, Hamilton AM, Mazmanian SK, Volpicelli-Daley LA, Gradinaru V Nature neuroscience 32066981 Nat Neurosci 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32066981
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan E, Huang SF, Kumar SR, Arokiaraj CM, Plattner V, Campos LJ, Mich J, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore B, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V bioRxiv : the preprint server for biology 36711773 bioRxiv 2023 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/36711773
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V Nature communications 37291094 Nat Commun 2023 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/37291094
Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V Chemistry & biology 26211362 Chem Biol 2015 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/26211362
Single-cell phenotyping within transparent intact tissue through whole-body clearing. Yang B, Treweek JB, Kulkarni RP, Deverman BE, Chen CK, Lubeck E, Shah S, Cai L, Gradinaru V Cell 25088144 Cell 2014 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/25088144
Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors. Treweek JB, Gradinaru V Current opinion in biotechnology 27393829 Curr Opin Biotechnol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27393829
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses. Kahan A, Greenbaum A, Jang MJ, Robinson JE, Cho JR, Chen X, Kassraian P, Wagenaar DA, Gradinaru V Cell reports 34592157 Cell Rep 2021 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/34592157
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Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. Zhang K, Duan L, Ong Q, Lin Z, Varman PM, Sung K, Cui B PloS one 24667437 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24667437
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Control of cerebral ischemia with magnetic nanoparticles. Jia JM, Chowdary PD, Gao X, Ci B, Li W, Mulgaonkar A, Plautz EJ, Hassan G, Kumar A, Stowe AM, Yang SH, Zhou W, Sun X, Cui B, Ge WP Nature methods 27941784 Nat Methods 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27941784
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Visualizing directional Rab7 and TrkA cotrafficking in axons by pTIRF microscopy. Zhang K, Chowdary PD, Cui B Methods in molecular biology (Clifton, N.J.) 25800854 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25800854
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The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. Che DL, Duan L, Zhang K, Cui B ACS synthetic biology 25985220 ACS Synth Biol 2015 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/25985220
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Circuit-Based Understanding of Fine Spatial Scale Clustering of Orientation Tuning in Mouse Visual Cortex. Yu P, Yang Y, Gozel O, Oldenburg I, Dipoppa M, Rossi LF, Miller K, Adesnik H, Ji N, Doiron B bioRxiv : the preprint server for biology 39990306 bioRxiv 2025 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/39990306
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Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo. Muir J, Anguiano M, Kim CK Science (New York, N.Y.) 39325905 Science 2024 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/39325905
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A hippocampal circuit mechanism to balance memory reactivation during sleep. Karaba LA, Robinson HL, Harvey RE, Chen W, Fernandez-Ruiz A, Oliva A Science (New York, N.Y.) 39146421 Science 2024 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/39146421
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The molecular landscape of vascular cells in the human brain. Crouch EE Nature reviews. Cardiology 39304749 Nat Rev Cardiol 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39304749
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The performance of 11 fingertip pulse oximeters during hypoxemia in healthy human participants with varied, quantified skin pigment. Leeb G, Auchus I, Law T, Bickler P, Feiner J, Hashi S, Monk E, Igaga E, Bernstein M, Chou YC, Hughes C, Schornack D, Lester J, Moore K Jr, Okunlola O, Fernandez J, Shmuylovich L, Lipnick M EBioMedicine 38458110 EBioMedicine 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38458110
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Protein-Based Tools for Studying Neuromodulation. Wang W ACS chemical biology 38581649 ACS Chem Biol 2024 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/38581649
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Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. Pan L, Trimarco A, Zhang AJ, Fujimori K, Urade Y, Sun LO, Taveggia C, Zhang Y eLife 36779701 Elife 2023 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/36779701
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Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity. Bhambri A, Thai P, Wei S, Bae HG, Barbosa D, Sharma T, Yu Z, Xing C, Kim JH, Yu G, Sun LO bioRxiv : the preprint server for biology 39763780 bioRxiv 2024 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/39763780
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sciLaMA: A Single-Cell Representation Learning Framework to Leverage Prior Knowledge from Large Language Models. Hu H, Zhang S, Choi Y, Malladi VS, Quon G bioRxiv : the preprint server for biology 40501921 bioRxiv 2025 May 29 https://www.ncbi.nlm.nih.gov/pubmed/40501921
MiniXL: An open-source, large field-of-view epifluorescence miniature microscope for mice capable of single-cell resolution and multi-brain region imaging. Zhao P, Guo C, Xie M, Chen L, Golshani P, Aharoni D bioRxiv : the preprint server for biology 39229051 bioRxiv 2024 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/39229051
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A nociceptive amygdala-striatal pathway for chronic pain aversion. Wojick JA, Paranjapye A, Chiu JK, Mahmood M, Oswell C, Kimmey BA, Wooldridge LM, McCall NM, Han A, Ejoh LL, Chehimi SN, Crist RC, Reiner BC, Korb E, Corder G bioRxiv : the preprint server for biology 38405972 bioRxiv 2024 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/38405972
Loss of DOT1L disrupts neuronal transcription, behavior, and leads to a neurodevelopmental disorder. Maroni MJ, Barton M, Lynch K, Deshwar AR, Campbell PD, Millard J, Lee R, Cohen A, Ahmad R, Paranjapye A, Faundes V, Repetto GM, McKenna C, Shillington AL, Phornphutkul C, Hove HB, Mancini GMS, Schot R, Barakat TS, Richmond CM, Lauzon J, Ibrahim AIE, Nava C, Héron D, van Aalst MMA, Atemin S, Sleptsova M, Aleksandrova I, Todorova A, Watkins DL, Kozenko MA, Natera-de Benito D, Ortez C, Estevez-Arias B, Lecoquierre F, Cassinari K, Guerrot AM, Levy J, Latypova X, Verloes A, Innes AM, Yang XR, Banka S, Vill K, Jacob M, Kruer M, Skidmore P, Galaz-Montoya CI, Bakhtiari S, Mester JL, Granato M, Armache KJ, Costain G, Korb E medRxiv : the preprint server for health sciences 39574879 medRxiv 2025 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/39574879
Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory. Feierman ER, Louzon S, Prescott NA, Biaco T, Gao Q, Qiu Q, Choi K, Palozola KC, Voss AJ, Mehta SD, Quaye CN, Lynch KT, Fuccillo MV, Wu H, David Y, Korb E Molecular cell 40049161 Mol Cell 2025 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/40049161
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Interpersonal and self-directed violence among sexual and gender minority populations: Moving research from prevalence to prevention. Blosnich JR Current epidemiology reports 36845319 Curr Epidemiol Rep 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36845319
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Concept Analysis: Challenge Coins as a Caring Support Tool to Prevent Farmer Suicide. Ward JM, Blosnich JR, Dean-Witt C Journal of agromedicine 39440398 J Agromedicine 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39440398
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A novel rhodopsin-based voltage indicator for simultaneous two-photon optical recording with GCaMP in vivo. Villette V, Yang S, Valenti R, Macklin JJ, Bradley J, Mathieu B, Lombardini A, Podgorski K, Dieudonné S, Schreiter ER, Abdelfattah AS bioRxiv : the preprint server for biology 39605646 bioRxiv 2024 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/39605646
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Tuning cohesin trajectories enables differential readout of the Pcdhα cluster across neurons. Kiefer L, Gaudin S, Rajkumar SM, Servito GIF, Langen J, Mui MH, Nawsheen S, Canzio D Science (New York, N.Y.) 39052779 Science 2024 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/39052779
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Dissociative and prioritized modeling of behaviorally relevant neural dynamics using recurrent neural networks. Sani OG, Pesaran B, Shanechi MM Nature neuroscience 39242944 Nat Neurosci 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39242944
Modeling multiscale causal interactions between spiking and field potential signals during behavior. Wang C, Pesaran B, Shanechi MM Journal of neural engineering 35073530 J Neural Eng 2022 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/35073530
Multimodal subspace identification for modeling discrete-continuous spiking and field potential population activity. Ahmadipour P, Sani OG, Pesaran B, Shanechi MM Journal of neural engineering 38016450 J Neural Eng 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/38016450
Dynamical flexible inference of nonlinear latent factors and structures in neural population activity. Abbaspourazad H, Erturk E, Pesaran B, Shanechi MM Nature biomedical engineering 38082181 Nat Biomed Eng 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38082181
Unsupervised learning of stationary and switching dynamical system models from Poisson observations. Song CY, Shanechi MM Journal of neural engineering 38083862 J Neural Eng 2023 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/38083862
Single Cell Transcriptome of Stress Vulnerability Network in mouse Prefrontal Cortex. Hing B, Mitchell SB, Eberle M, Filali Y, Hultman I, Matkovich M, Kasturirangan M, Wyche W, Jimenez A, Velamuri R, Johnson M, Srivastava S, Hultman R bioRxiv : the preprint server for biology 37662266 bioRxiv 2023 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/37662266
Transcriptomic Evaluation of a Stress Vulnerability Network Using Single-Cell RNA Sequencing in Mouse Prefrontal Cortex. Hing B, Mitchell SB, Filali Y, Eberle M, Hultman I, Matkovich M, Kasturirangan M, Johnson M, Wyche W, Jimenez A, Velamuri R, Ghumman M, Wickramasinghe H, Christian O, Srivastava S, Hultman R Biological psychiatry 38866174 Biol Psychiatry 2024 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/38866174
An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies. McCutcheon N, Johnson MS, Rea B, Ghumman M, Sowers L, Hultman R Journal of visualized experiments : JoVE 39555788 J Vis Exp 2024 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/39555788
Acetylcholine demixes heterogeneous dopamine signals for learning and moving. Jang HJ, Ward RM, Golden CEM, Constantinople CM bioRxiv : the preprint server for biology 38746300 bioRxiv 2024 May 4 https://www.ncbi.nlm.nih.gov/pubmed/38746300
Neural dynamics in the orbitofrontal cortex reveal cognitive strategies. Schiereck SS, Pérez-Rivera DT, Mah A, DeMaegd ML, Ward RM, Hocker D, Savin C, Constantinople CM bioRxiv : the preprint server for biology 39554155 bioRxiv 2024 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/39554155
Dopamine transients encode reward prediction errors independent of learning rates. Mah A, Golden CEM, Constantinople CM Cell reports 39395170 Cell Rep 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/39395170
Dopamine transients encode reward prediction errors independent of learning rates. Mah A, Golden CEM, Constantinople CM bioRxiv : the preprint server for biology 38659861 bioRxiv 2024 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/38659861
Distinct value computations support rapid sequential decisions. Mah A, Schiereck SS, Bossio V, Constantinople CM bioRxiv : the preprint server for biology 36993514 bioRxiv 2023 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/36993514
Distinct value computations support rapid sequential decisions. Mah A, Schiereck SS, Bossio V, Constantinople CM Nature communications 37989741 Nat Commun 2023 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/37989741
Independent inhibitory control mechanisms for aggressive motivation and action. Minakuchi T, Guthman EM, Acharya P, Hinson J, Fleming W, Witten IB, Oline SN, Falkner AL Nature neuroscience 38347201 Nat Neurosci 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38347201
Aggression experience and observation promote shared behavioral and neural changes. Iravedra-Garcia JM, Guthman EM, Cuturela L, Ocasio-Arce EJ, Pillow JW, Falkner AL bioRxiv : the preprint server for biology 39763843 bioRxiv 2024 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/39763843
Behavioural and dopaminergic signatures of resilience. Willmore L, Cameron C, Yang J, Witten IB, Falkner AL Nature 36261520 Nature 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36261520
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SLEAP: A deep learning system for multi-animal pose tracking. Pereira TD, Tabris N, Matsliah A, Turner DM, Li J, Ravindranath S, Papadoyannis ES, Normand E, Deutsch DS, Wang ZY, McKenzie-Smith GC, Mitelut CC, Castro MD, D'Uva J, Kislin M, Sanes DH, Kocher SD, Wang SS, Falkner AL, Shaevitz JW, Murthy M Nature methods 35379947 Nat Methods 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35379947
Toward a neurobiological model of human performance under pressure. Saikley A, Haroush K Proceedings of the National Academy of Sciences of the United States of America 34470823 Proc Natl Acad Sci U S A 2021 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/34470823
The synaptic basis of activity-dependent eye-specific competition. Zhang C, Yadav S, Speer CM Cell reports 36753422 Cell Rep 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/36753422
Activity-dependent synapse clustering underlies eye-specific competition in the developing retinogeniculate system. Zhang C, Vatan T, Speer CM bioRxiv : the preprint server for biology 39484601 bioRxiv 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/39484601
Volumetric super-resolution imaging by serial ultrasectioning and stochastic optical reconstruction microscopy in mouse neural tissue. Vatan T, Minehart JA, Zhang C, Agarwal V, Yang J, Speer CM STAR protocols 34901889 STAR Protoc 2021 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/34901889
Microanalytical Mass Spectrometry with Super-Resolution Microscopy Reveals a Proteome Transition During Development of the Brain's Circadian Pacemaker. Choi SB, Vatan T, Alexander TA, Zhang C, Mitchell SM, Speer CM, Nemes P Analytical chemistry 37792996 Anal Chem 2023 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/37792996
A Picture Worth a Thousand Molecules-Integrative Technologies for Mapping Subcellular Molecular Organization and Plasticity in Developing Circuits. Minehart JA, Speer CM Frontiers in synaptic neuroscience 33469427 Front Synaptic Neurosci 2020 https://www.ncbi.nlm.nih.gov/pubmed/33469427
Rapid 3D-STORM imaging of diverse molecular targets in tissue. Albrecht NE, Jiang D, Akhanov V, Hobson R, Speer CM, Robichaux MA, Samuel MA Cell reports methods 35880013 Cell Rep Methods 2022 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/35880013
A pheromone receptor in cichlid fish mediates attraction to females but inhibits male parental care. Li CY, Bowers JM, Alexander TA, Behrens KA, Jackson P, Amini CJ, Juntti SA Current biology : CB 39094572 Curr Biol 2024 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/39094572
Methods for correcting inference based on outcomes predicted by machine learning. Wang S, McCormick TH, Leek JT Proceedings of the National Academy of Sciences of the United States of America 33208538 Proc Natl Acad Sci U S A 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/33208538
Using Aggregated Relational Data to Feasibly Identify Network Structure without Network Data. Breza E, Chandrasekhar AG, McCormick TH, Pan M The American economic review 34526729 Am Econ Rev 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/34526729
Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission. Markwalter CF, Lapp Z, Abel L, Kimachas E, Omollo E, Freedman E, Chepkwony T, Amunga M, McCormick T, Bérubé S, Mangeni JN, Wesolowski A, Obala AA, Taylor SM, Prudhomme O'Meara W Nature communications 38816383 Nat Commun 2024 May 30 https://www.ncbi.nlm.nih.gov/pubmed/38816383
Consistently estimating network statistics using aggregated relational data. Breza E, Chandrasekhar AG, Lubold S, McCormick TH, Pan M Proceedings of the National Academy of Sciences of the United States of America 37192169 Proc Natl Acad Sci U S A 2023 May 23 https://www.ncbi.nlm.nih.gov/pubmed/37192169
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Using Bayesian Latent Gaussian Graphical Models to Infer Symptom Associations in Verbal Autopsies. Li ZR, McComick TH, Clark SJ Bayesian analysis 33273996 Bayesian Anal 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/33273996
Quantifying heterogeneity in SARS-CoV-2 transmission during the lockdown in India. Arinaminpathy N, Das J, McCormick TH, Mukhopadhyay P, Sircar N Epidemics 34171509 Epidemics 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34171509
Quantifying heterogeneity in SARS-CoV-2 transmission during the lockdown in India. Arinaminpathy N, Das J, McCormick TH, Mukhopadhyay P, Sircar N medRxiv : the preprint server for health sciences 32995809 medRxiv 2020 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/32995809
A FLEXIBLE BAYESIAN FRAMEWORK TO ESTIMATE AGE- AND CAUSE-SPECIFIC CHILD MORTALITY OVER TIME FROM SAMPLE REGISTRATION DATA. Schumacher AE, McCormick TH, Wakefield J, Chu Y, Perin J, Villavicencio F, Simon N, Liu L The annals of applied statistics 37621750 Ann Appl Stat 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/37621750
Comparing the Robustness of Simple Network Scale-Up Method Estimators. Kunke JP, Laga I, Niu X, McCormick TH Sociological methodology 39391075 Sociol Methodol 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/39391075
Simultaneous interneuron labeling reveals population-level interactions among parvalbumin, somatostatin, and pyramidal neurons in cortex. Potter C, Bassi C, Runyan CA bioRxiv : the preprint server for biology 36711788 bioRxiv 2024 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/36711788
The spatial scale of somatostatin subnetworks increases from sensory to association cortex. Khoury CF, Fala NG, Runyan CA Cell reports 36070697 Cell Rep 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/36070697
Local Differences in Network Organization in the Auditory and Parietal Cortex, Revealed with Single Neuron Activation. Khoury CF, Ferrone M, Runyan CA The Journal of neuroscience : the official journal of the Society for Neuroscience 39890466 J Neurosci 2025 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/39890466
Different state-dependence of population codes across cortex. Bandi AC, Runyan CA bioRxiv : the preprint server for biology 38826351 bioRxiv 2024 May 26 https://www.ncbi.nlm.nih.gov/pubmed/38826351
Arousal and Locomotion Differently Modulate Activity of Somatostatin Neurons across Cortex. Khoury CF, Fala NG, Runyan CA eNeuro 37169583 eNeuro 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37169583
Simultaneous interneuron labeling reveals cell type-specific, population-level interactions in cortex. Potter CT, Bassi CD, Runyan CA iScience 39280622 iScience 2024 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/39280622
Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Ramaswami G, Won H, Gandal MJ, Haney J, Wang JC, Wong CCY, Sun W, Prabhakar S, Mill J, Geschwind DH Nature communications 32978376 Nat Commun 2020 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/32978376
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Sey NYA, Hu B, Mah W, Fauni H, McAfee JC, Rajarajan P, Brennand KJ, Akbarian S, Won H Nature neuroscience 32152537 Nat Neurosci 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32152537
Regulatory landscape in brain development and disease. Spiess K, Won H Current opinion in genetics & development 32563855 Curr Opin Genet Dev 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32563855
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants. McAfee JC, Lee S, Lee J, Bell JL, Krupa O, Davis J, Insigne K, Bond ML, Zhao N, Boyle AP, Phanstiel DH, Love MI, Stein JL, Ruzicka WB, Davila-Velderrain J, Kosuri S, Won H Cell genomics 37868037 Cell Genom 2023 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/37868037
Focus on your locus with a massively parallel reporter assay. McAfee JC, Bell JL, Krupa O, Matoba N, Stein JL, Won H Journal of neurodevelopmental disorders 36085003 J Neurodev Disord 2022 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/36085003
Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review. Raznahan A, Won H, Glahn DC, Jacquemont S JAMA psychiatry 35767289 JAMA Psychiatry 2022 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/35767289
Advances in profiling chromatin architecture shed light on the regulatory dynamics underlying brain disorders. Pratt BM, Won H Seminars in cell & developmental biology 34483043 Semin Cell Dev Biol 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34483043
Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Sey NYA, Hu B, Iskhakova M, Lee S, Sun H, Shokrian N, Ben Hutta G, Marks JA, Quach BC, Johnson EO, Hancock DB, Akbarian S, Won H Molecular psychiatry 35422469 Mol Psychiatry 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35422469
Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons. Plooster M, Rossi G, Farrell MS, McAfee JC, Bell JL, Ye M, Diering GH, Won H, Gupton SL, Brennwald P The Journal of neuroscience : the official journal of the Society for Neuroscience 34642214 J Neurosci 2021 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/34642214
Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism. Matoba N, Liang D, Sun H, Aygün N, McAfee JC, Davis JE, Raffield LM, Qian H, Piven J, Li Y, Kosuri S, Won H, Stein JL Translational psychiatry 32747698 Transl Psychiatry 2020 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/32747698
Chromatin architecture provides a roadmap to improve our understanding of psychiatric disorders. Hu B, Won H Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 32859998 Neuropsychopharmacology 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32859998
Annotating genetic variants to target genes using H-MAGMA. Sey NYA, Pratt BM, Won H Nature protocols 36289406 Nat Protoc 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36289406
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders. Lee S, McAfee JC, Lee J, Gomez A, Ledford AT, Clarke D, Min H, Gerstein MB, Boyle AP, Sullivan PF, Beltran AS, Won H Cell 39848247 Cell 2025 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/39848247
Limited Association between Schizophrenia Genetic Risk Factors and Transcriptomic Features. Yu AW, Peery JD, Won H Genes 34356078 Genes (Basel) 2021 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/34356078
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Hu B, Won H, Mah W, Park RB, Kassim B, Spiess K, Kozlenkov A, Crowley CA, Pochareddy S, PsychENCODE Consortium, Li Y, Dracheva S, Sestan N, Akbarian S, Geschwind DH Nature communications 34172755 Nat Commun 2021 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/34172755
Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex. Liu S, Won H, Clarke D, Matoba N, Khullar S, Mu Y, Wang D, Gerstein M Genome medicine 36424644 Genome Med 2022 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/36424644
HIV integration in the human brain is linked to microglial activation and 3D genome remodeling. Plaza-Jennings AL, Valada A, O'Shea C, Iskhakova M, Hu B, Javidfar B, Ben Hutta G, Lambert TY, Murray J, Kassim B, Chandrasekaran S, Chen BK, Morgello S, Won H, Akbarian S Molecular cell 36525955 Mol Cell 2022 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/36525955
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB Nature communications 33144568 Nat Commun 2020 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/33144568
Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features. Bond ML, Davis ES, Quiroga IY, Dey A, Kiran M, Love MI, Won H, Phanstiel DH Genome research 37699658 Genome Res 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37699658
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development. Liu D, Zinski A, Mishra A, Noh H, Park GH, Qin Y, Olorife O, Park JM, Abani CP, Park JS, Fung J, Sawaqed F, Coyle JT, Stahl E, Bendl J, Fullard JF, Roussos P, Zhang X, Stanton PK, Yin C, Huang W, Kim HY, Won H, Cho JH, Chung S Molecular psychiatry 35701597 Mol Psychiatry 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35701597
Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia. Wen J, Trost B, Engchuan W, Halvorsen M, Pallotto LM, Mitina A, Ancalade N, Farrell M, Backstrom I, Guo K, Pellecchia G, Thiruvahindrapuram B, Giusti-Rodriguez P, Rosen JD, Li Y, Won H, Magnusson PKE, Gyllensten U, Bassett AS, Hultman CM, Sullivan PF, Yuen RKC, Szatkiewicz JP Molecular psychiatry 36380236 Mol Psychiatry 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36380236
Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction. Kaelberer MM, Rupprecht LE, Liu WW, Weng P, Bohórquez DV Annual review of neuroscience 32101483 Annu Rev Neurosci 2020 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/32101483
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind. Alway E, Reicher N, Bohórquez DV Genes & development 39362782 Genes Dev 2024 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/39362782
The nerve not taken. Rupprecht LE, Bohórquez DV Cell metabolism 33657390 Cell Metab 2021 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/33657390
Viscera affectum anno: the gut beyond eating behaviours. Bohórquez DV Nature reviews. Gastroenterology & hepatology 33262502 Nat Rev Gastroenterol Hepatol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33262502
Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits. Sahasrabudhe A, Rupprecht LE, Orguc S, Khudiyev T, Tanaka T, Sands J, Zhu W, Tabet A, Manthey M, Allen H, Loke G, Antonini MJ, Rosenfeld D, Park J, Garwood IC, Yan W, Niroui F, Fink Y, Chandrakasan A, Bohórquez DV, Anikeeva P Nature biotechnology 37349522 Nat Biotechnol 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/37349522
The preference for sugar over sweetener depends on a gut sensor cell. Buchanan KL, Rupprecht LE, Kaelberer MM, Sahasrabudhe A, Klein ME, Villalobos JA, Liu WW, Yang A, Gelman J, Park S, Anikeeva P, Bohórquez DV Nature neuroscience 35027761 Nat Neurosci 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35027761
The neural basis of sugar preference. Liu WW, Bohórquez DV Nature reviews. Neuroscience 35879409 Nat Rev Neurosci 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35879409
Interfacing behavioral and neural circuit models for habit formation. Lerner TN Journal of neuroscience research 31916623 J Neurosci Res 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/31916623
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Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres. Poulopoulos A, Davis P, Brandenburg C, Itoh Y, Galazo MJ, Greig LC, Romanowski AJ, Budnik B, Macklis JD bioRxiv : the preprint server for biology 38585721 bioRxiv 2024 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/38585721
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Neuronal mTOR Outposts: Implications for Translation, Signaling, and Plasticity. Altas B, Romanowski AJ, Bunce GW, Poulopoulos A Frontiers in cellular neuroscience 35465614 Front Cell Neurosci 2022 https://www.ncbi.nlm.nih.gov/pubmed/35465614
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Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder. Pasquini L, Fryer SL, Eisendrath SJ, Segal ZV, Lee AJ, Brown JA, Saggar M, Mathalon DH Biological psychiatry. Cognitive neuroscience and neuroimaging 36754677 Biol Psychiatry Cogn Neurosci Neuroimaging 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/36754677
NeuMapper: A scalable computational framework for multiscale exploration of the brain's dynamical organization. Geniesse C, Chowdhury S, Saggar M Network neuroscience (Cambridge, Mass.) 35733428 Netw Neurosci 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35733428
Spontaneous and deliberate modes of creativity: Multitask eigen-connectivity analysis captures latent cognitive modes during creative thinking. Xie H, Beaty RE, Jahanikia S, Geniesse C, Sonalkar NS, Saggar M NeuroImage 34469816 Neuroimage 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34469816
Altered canonical and striatal-frontal resting state functional connectivity in children with pathogenic variants in the Ras/mitogen-activated protein kinase pathway. Bruno JL, Shrestha SB, Reiss AL, Saggar M, Green T Molecular psychiatry 35087195 Mol Psychiatry 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35087195
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Deconstructing the Mapper algorithm to extract richer topological and temporal features from functional neuroimaging data. Haşegan D, Geniesse C, Chowdhury S, Saggar M bioRxiv : the preprint server for biology 37904918 bioRxiv 2023 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/37904918
Neural resources shift under Methylphenidate: A computational approach to examine anxiety-cognition interplay. Saggar M, Bruno J, Gaillard C, Claudino L, Ernst M NeuroImage 36273770 Neuroimage 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36273770
Development of top-down cortical propagations in youth. Pines A, Keller AS, Larsen B, Bertolero M, Ashourvan A, Bassett DS, Cieslak M, Covitz S, Fan Y, Feczko E, Houghton A, Rueter AR, Saggar M, Shafiei G, Tapera TM, Vogel J, Weinstein SM, Shinohara RT, Williams LM, Fair DA, Satterthwaite TD Neuron 36803653 Neuron 2023 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/36803653
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice. Rosenberg AM, Saggar M, Monzel AS, Devine J, Rogu P, Limoges A, Junker A, Sandi C, Mosharov EV, Dumitriu D, Anacker C, Picard M Nature communications 37563104 Nat Commun 2023 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/37563104
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Densely sampled stimulus-response map of human cortex with single pulse TMS-EEG and its relation to whole brain neuroimaging measures. Sun Y, Lucas MV, Cline CC, Menezes MC, Kim S, Badami FS, Narayan M, Wu W, Daskalakis ZJ, Etkin A, Saggar M bioRxiv : the preprint server for biology 38948696 bioRxiv 2024 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/38948696
Cross-attractor repertoire provides new perspective on structure-function relationship in the brain. Zhang M, Sun Y, Saggar M NeuroImage 35732244 Neuroimage 2022 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/35732244
Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults. Ayub R, Sun KL, Flores RE, Lam VT, Jo B, Saggar M, Fung LK Translational psychiatry 33536431 Transl Psychiatry 2021 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/33536431
Generating dynamical neuroimaging spatiotemporal representations (DyNeuSR) using topological data analysis. Geniesse C, Sporns O, Petri G, Saggar M Network neuroscience (Cambridge, Mass.) 31410378 Netw Neurosci 2019 https://www.ncbi.nlm.nih.gov/pubmed/31410378
Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders. Sun Y, Zhang M, Saggar M NeuroImage 37579998 Neuroimage 2023 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/37579998
Precision dynamical mapping using topological data analysis reveals a hub-like transition state at rest. Saggar M, Shine JM, Liégeois R, Dosenbach NUF, Fair D Nature communications 35970984 Nat Commun 2022 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/35970984
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How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles. Harbert KJ, Pellegrini M, Gordon KM, Donaldson ZR Hormones and behavior 32910950 Horm Behav 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32910950
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Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering. Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL Neuron 32574560 Neuron 2020 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/32574560
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Virally encoded connectivity transgenic overlay RNA sequencing (VECTORseq) defines projection neurons involved in sensorimotor integration. Cheung V, Chung P, Bjorni M, Shvareva VA, Lopez YC, Feinberg EH Cell reports 34936877 Cell Rep 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34936877
Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell. Manz KM, Coleman BC, Grueter CA, Shields BC, Tadross MR, Grueter BA The Journal of neuroscience : the official journal of the Society for Neuroscience 33737458 J Neurosci 2021 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/33737458
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Natural phasic inhibition of dopamine neurons signals cognitive rigidity. Burwell SCV, Yan H, Lim SSX, Shields BC, Tadross MR bioRxiv : the preprint server for biology 38766037 bioRxiv 2024 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/38766037
An open-source transparent microelectrode array. Weaver IA, Li AW, Shields BC, Tadross MR Journal of neural engineering 35349992 J Neural Eng 2022 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/35349992
Acute restraint stress redirects prefrontal cortex circuit function through mGlu(5) receptor plasticity on somatostatin-expressing interneurons. Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ Neuron 35045338 Neuron 2022 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/35045338
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Genomic structural variation: A complex but important driver of human evolution. Soto DC, Uribe-Salazar JM, Shew CJ, Sekar A, McGinty SP, Dennis MY American journal of biological anthropology 36794631 Am J Biol Anthropol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/36794631
FixItFelix: improving genomic analysis by fixing reference errors. Behera S, LeFaive J, Orchard P, Mahmoud M, Paulin LF, Farek J, Soto DC, Parker SCJ, Smith AV, Dennis MY, Zook JM, Sedlazeck FJ Genome biology 36810122 Genome Biol 2023 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/36810122
m(6)A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly. Nishizaki SS, Haghani NK, La GN, Mariano NAF, Uribe-Salazar JM, Kaya G, Regester M, Andrews DS, Nordahl CW, Amaral DG, Dennis MY Autism research : official journal of the International Society for Autism Research 39887636 Autism Res 2025 May https://www.ncbi.nlm.nih.gov/pubmed/39887636
Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing. Soto DC, Shew C, Mastoras M, Schmidt JM, Sahasrabudhe R, Kaya G, Andrés AM, Dennis MY Genes 32143403 Genes (Basel) 2020 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/32143403
Diverse Molecular Mechanisms Contribute to Differential Expression of Human Duplicated Genes. Shew CJ, Carmona-Mora P, Soto DC, Mastoras M, Roberts E, Rosas J, Jagannathan D, Kaya G, O'Geen H, Dennis MY Molecular biology and evolution 34009325 Mol Biol Evol 2021 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/34009325
Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism. Zhu Y, Gomez JA, Laufer BI, Mordaunt CE, Mouat JS, Soto DC, Dennis MY, Benke KS, Bakulski KM, Dou J, Marathe R, Jianu JM, Williams LA, Gutierrez Fugón OJ, Walker CK, Ozonoff S, Daniels J, Grosvenor LP, Volk HE, Feinberg JI, Fallin MD, Hertz-Picciotto I, Schmidt RJ, Yasui DH, LaSalle JM Genome biology 35168652 Genome Biol 2022 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/35168652
Telomere-to-telomere assembly of a complete human X chromosome. Miga KH, Koren S, Rhie A, Vollger MR, Gershman A, Bzikadze A, Brooks S, Howe E, Porubsky D, Logsdon GA, Schneider VA, Potapova T, Wood J, Chow W, Armstrong J, Fredrickson J, Pak E, Tigyi K, Kremitzki M, Markovic C, Maduro V, Dutra A, Bouffard GG, Chang AM, Hansen NF, Wilfert AB, Thibaud-Nissen F, Schmitt AD, Belton JM, Selvaraj S, Dennis MY, Soto DC, Sahasrabudhe R, Kaya G, Quick J, Loman NJ, Holmes N, Loose M, Surti U, Risques RA, Graves Lindsay TA, Fulton R, Hall I, Paten B, Howe K, Timp W, Young A, Mullikin JC, Pevzner PA, Gerton JL, Sullivan BA, Eichler EE, Phillippy AM Nature 32663838 Nature 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32663838
Assessment of Autism Zebrafish Mutant Models Using a High-Throughput Larval Phenotyping Platform. Colón-Rodríguez A, Uribe-Salazar JM, Weyenberg KB, Sriram A, Quezada A, Kaya G, Jao E, Radke B, Lein PJ, Dennis MY Frontiers in cell and developmental biology 33330465 Front Cell Dev Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/33330465
Complete genomic and epigenetic maps of human centromeres. Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SJ, Uralsky L, Ryabov FD, Shew CJ, Sauria MEG, Borchers M, Gershman A, Mikheenko A, Shepelev VA, Dvorkina T, Kunyavskaya O, Vollger MR, Rhie A, McCartney AM, Asri M, Lorig-Roach R, Shafin K, Lucas JK, Aganezov S, Olson D, de Lima LG, Potapova T, Hartley GA, Haukness M, Kerpedjiev P, Gusev F, Tigyi K, Brooks S, Young A, Nurk S, Koren S, Salama SR, Paten B, Rogaev EI, Streets A, Karpen GH, Dernburg AF, Sullivan BA, Straight AF, Wheeler TJ, Gerton JL, Eichler EE, Phillippy AM, Timp W, Dennis MY, O'Neill RJ, Zook JM, Schatz MC, Pevzner PA, Diekhans M, Langley CH, Alexandrov IA, Miga KH Science (New York, N.Y.) 35357911 Science 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35357911
The complete sequence of a human genome. Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A, Aganezov S, Hoyt SJ, Diekhans M, Logsdon GA, Alonge M, Antonarakis SE, Borchers M, Bouffard GG, Brooks SY, Caldas GV, Chen NC, Cheng H, Chin CS, Chow W, de Lima LG, Dishuck PC, Durbin R, Dvorkina T, Fiddes IT, Formenti G, Fulton RS, Fungtammasan A, Garrison E, Grady PGS, Graves-Lindsay TA, Hall IM, Hansen NF, Hartley GA, Haukness M, Howe K, Hunkapiller MW, Jain C, Jain M, Jarvis ED, Kerpedjiev P, Kirsche M, Kolmogorov M, Korlach J, Kremitzki M, Li H, Maduro VV, Marschall T, McCartney AM, McDaniel J, Miller DE, Mullikin JC, Myers EW, Olson ND, Paten B, Peluso P, Pevzner PA, Porubsky D, Potapova T, Rogaev EI, Rosenfeld JA, Salzberg SL, Schneider VA, Sedlazeck FJ, Shafin K, Shew CJ, Shumate A, Sims Y, Smit AFA, Soto DC, Sović I, Storer JM, Streets A, Sullivan BA, Thibaud-Nissen F, Torrance J, Wagner J, Walenz BP, Wenger A, Wood JMD, Xiao C, Yan SM, Young AC, Zarate S, Surti U, McCoy RC, Dennis MY, Alexandrov IA, Gerton JL, O'Neill RJ, Timp W, Zook JM, Schatz MC, Eichler EE, Miga KH, Phillippy AM Science (New York, N.Y.) 35357919 Science 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35357919
RapID Cell Counter: Semi-Automated and Mid-Throughput Estimation of Cell Density within Diverse Cortical Layers. Sekar A, Sanches TM, Hino K, Kumar M, Wang J, Ha E, Durbin-Johnson B, Simó S, Dennis MY eNeuro 34725102 eNeuro 2021 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/34725102
A complete reference genome improves analysis of human genetic variation. Aganezov S, Yan SM, Soto DC, Kirsche M, Zarate S, Avdeyev P, Taylor DJ, Shafin K, Shumate A, Xiao C, Wagner J, McDaniel J, Olson ND, Sauria MEG, Vollger MR, Rhie A, Meredith M, Martin S, Lee J, Koren S, Rosenfeld JA, Paten B, Layer R, Chin CS, Sedlazeck FJ, Hansen NF, Miller DE, Phillippy AM, Miga KH, McCoy RC, Dennis MY, Zook JM, Schatz MC Science (New York, N.Y.) 35357935 Science 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35357935
Evaluation of CRISPR gene-editing tools in zebrafish. Uribe-Salazar JM, Kaya G, Sekar A, Weyenberg K, Ingamells C, Dennis MY BMC genomics 34986794 BMC Genomics 2022 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/34986794
LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons. Libé-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Konstantoulea K, Nyitrai H, De Vleeschouwer M, Vennekens KM, Vidal N, Bird TW, Soto DC, Jaspers T, Dewilde M, Dennis MY, Rousseau F, Comoletti D, Schymkowitz J, Theys T, de Wit J, Vanderhaeghen P Cell 38134874 Cell 2023 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/38134874
Zebrafish models of human-duplicated SRGAP2 reveal novel functions in microglia and visual system development. Uribe-Salazar JM, Kaya G, Weyenberg K, Radke B, Hino K, Soto DC, Shiu JL, Zhang W, Ingamells C, Haghani NK, Xu E, Rosas J, Simó S, Miesfeld J, Glaser T, Baraban SC, Jao LE, Dennis MY bioRxiv : the preprint server for biology 39314374 bioRxiv 2024 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/39314374
Local genetic adaptation to habitat in wild chimpanzees. Ostridge HJ, Fontsere C, Lizano E, Soto DC, Schmidt JM, Saxena V, Alvarez-Estape M, Barratt CD, Gratton P, Bocksberger G, Lester JD, Dieguez P, Agbor A, Angedakin S, Assumang AK, Bailey E, Barubiyo D, Bessone M, Brazzola G, Chancellor R, Cohen H, Coupland C, Danquah E, Deschner T, Dotras L, Dupain J, Egbe VE, Granjon AC, Head J, Hedwig D, Hermans V, Hernandez-Aguilar RA, Jeffery KJ, Jones S, Junker J, Kadam P, Kaiser M, Kalan AK, Kambere M, Kienast I, Kujirakwinja D, Langergraber KE, Lapuente J, Larson B, Laudisoit A, Lee KC, Llana M, Maretti G, Martín R, Meier A, Morgan D, Neil E, Nicholl S, Nixon S, Normand E, Orbell C, Ormsby LJ, Orume R, Pacheco L, Preece J, Regnaut S, Robbins MM, Rundus A, Sanz C, Sciaky L, Sommer V, Stewart FA, Tagg N, Tédonzong LR, van Schijndel J, Vendras E, Wessling EG, Willie J, Wittig RM, Yuh YG, Yurkiw K, Vigilant L, Piel A, Boesch C, Kühl HS, Dennis MY, Marques-Bonet T, Arandjelovic M, Andrés AM bioRxiv : the preprint server for biology 39026872 bioRxiv 2024 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/39026872
Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder. de Jong JO, Llapashtica C, Genestine M, Strauss K, Provenzano F, Sun Y, Zhu H, Cortese GP, Brundu F, Brigatti KW, Corneo B, Migliori B, Tomer R, Kushner SA, Kellendonk C, Javitch JA, Xu B, Markx S Nature communications 34471112 Nat Commun 2021 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/34471112
Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms. Dayton H, Kiss J, Wei M, Chauhan S, LaMarre E, Cornell WC, Morgan CJ, Janakiraman A, Min W, Tomer R, Price-Whelan A, Nirody JA, Dietrich LEP PLoS biology 38300958 PLoS Biol 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38300958
Scalable projected Light Sheet Microscopy for high-resolution imaging of living and cleared samples. Chen Y, Chauhan S, Gong C, Dayton H, Xu C, De La Cruz ED, Datta MS, Leong KW, Dietrich LEP, Tomer R bioRxiv : the preprint server for biology 37333196 bioRxiv 2023 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/37333196
Focused ultrasound-mediated brain genome editing. Lao YH, Ji R, Zhou JK, Snow KJ, Kwon N, Saville E, He S, Chauhan S, Chi CW, Datta MS, Zhang H, Quek CH, Cai SS, Li M, Gaitan Y, Bechtel L, Wu SY, Lutz CM, Tomer R, Murray SA, Chavez A, Konofagou EE, Leong KW Proceedings of the National Academy of Sciences of the United States of America 37579143 Proc Natl Acad Sci U S A 2023 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/37579143
Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system. Datta MS, Chen Y, Chauhan S, Zhang J, De La Cruz ED, Gong C, Tomer R Cell reports 38052211 Cell Rep 2023 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/38052211
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A Microfluidic Dual-Aptamer Sandwich Assay for Rapid and Cost-Effective Detection of Recombinant Proteins. Wen K, Chen Y, Meng X, Botros S, Dai W, Stojanovic MN, Tomer R, Lin Q Microchemical journal : devoted to the application of microtechniques in all branches of science 36992861 Microchem J 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36992861
A miniaturized multi-clamp CMOS amplifier for intracellular neural recording. Shekar S, Jayant K, Rabadan MA, Tomer R, Yuste R, Shepard KL Nature electronics 31850397 Nat Electron 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31850397
Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples. Chen Y, Chauhan S, Gong C, Dayton H, Xu C, De La Cruz ED, Tsai YW, Datta MS, Rosoklija GB, Dwork AJ, Mann JJ, Boldrini M, Leong KW, Dietrich LEP, Tomer R Nature biomedical engineering 39209948 Nat Biomed Eng 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39209948
Light sheet theta microscopy for rapid high-resolution imaging of large biological samples. Migliori B, Datta MS, Dupre C, Apak MC, Asano S, Gao R, Boyden ES, Hermanson O, Yuste R, Tomer R BMC biology 29843722 BMC Biol 2018 May 29 https://www.ncbi.nlm.nih.gov/pubmed/29843722
Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system. Datta MS, Chen Y, Chauhan S, Zhang J, De La Cruz ED, Gong C, Tomer R bioRxiv : the preprint server for biology 37090584 bioRxiv 2023 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/37090584
Cell arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms. Dayton H, Kiss J, Wei M, Chauhan S, LaMarre E, Cornell WC, Morgan CJ, Janakiraman A, Min W, Tomer R, Price-Whelan A, Nirody JA, Dietrich LEP bioRxiv : the preprint server for biology 37645902 bioRxiv 2023 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/37645902
Focused ultrasound-mediated brain genome editing. Leong K, Lao YH, Ji R, Zhou J, Snow K, Kwon N, Saville E, He S, Chauhan S, Chi CW, Datta M, Zhang H, Quek CH, Cai S, Li M, Gaitan Y, Bechtel L, Wu SY, Lutz C, Tomer R, Murray S, Chavez A, Konofagou E Research square 36712096 Res Sq 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36712096
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Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV Science (New York, N.Y.) 29420261 Science 2018 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/29420261
Circuit and molecular architecture of a ventral hippocampal network. Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA Nature neuroscience 32929245 Nat Neurosci 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32929245
Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity. Rosenberg MF, Molofsky AV Trends in immunology 32800455 Trends Immunol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32800455
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham MC Nature neuroscience 30154505 Nat Neurosci 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30154505
Type I interferon responsive microglia shape cortical development and behavior. Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Cuevas B, Vainchtein ID, Silva NJ, Xiao Y, Lidsky PV, Wang EY, Taloma SE, Nakao-Inoue H, Schwer B, Andino R, Nowakowski TJ, Molofsky AV bioRxiv : the preprint server for biology 35233577 bioRxiv 2023 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/35233577
The immune system and psychiatric disease: a basic science perspective. Bennett FC, Molofsky AV Clinical and experimental immunology 31125426 Clin Exp Immunol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31125426
Astrocytes and Microglia: In Sickness and in Health. Vainchtein ID, Molofsky AV Trends in neurosciences 32044129 Trends Neurosci 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32044129
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV Cell 32615087 Cell 2020 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/32615087
Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior. Szewczyk LM, Lipiec MA, Liszewska E, Meyza K, Urban-Ciecko J, Kondrakiewicz L, Goncerzewicz A, Rafalko K, Krawczyk TG, Bogaj K, Vainchtein ID, Nakao-Inoue H, Puscian A, Knapska E, Sanders SJ, Jan Nowakowski T, Molofsky AV, Wisniewska MB Molecular psychiatry 37798419 Mol Psychiatry 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37798419
Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Poskanzer KE, Molofsky AV Annual review of physiology 29166242 Annu Rev Physiol 2018 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/29166242
Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents. Cho FS, Vainchtein ID, Voskobiynyk Y, Morningstar AR, Aparicio F, Higashikubo B, Ciesielska A, Broekaart DWM, Anink JJ, van Vliet EA, Yu X, Khakh BS, Aronica E, Molofsky AV, Paz JT Science translational medicine 35857628 Sci Transl Med 2022 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/35857628
In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Silva NJ, Dorman LC, Vainchtein ID, Horneck NC, Molofsky AV Nature communications 34625548 Nat Commun 2021 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/34625548
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI eLife 34652270 Elife 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34652270
Type-I-interferon-responsive microglia shape cortical development and behavior. Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV Cell 38490196 Cell 2024 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/38490196
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scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Öztürk BE, Johnson ME, Kleyman M, Turunç S, He J, Jabalameli S, Xi Z, Visel M, Dufour VL, Iwabe S, Pompeo Marinho LFL, Aguirre GD, Sahel JA, Schaffer DV, Pfenning AR, Flannery JG, Beltran WA, Stauffer WR, Byrne LC eLife 34664552 Elife 2021 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/34664552
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Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L Scientific reports 29476125 Sci Rep 2018 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/29476125
Imaging Neurotransmitter and Neuromodulator Dynamics In Vivo with Genetically Encoded Indicators. Sabatini BL, Tian L Neuron 33058762 Neuron 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/33058762
Imaging voltage and brain chemistry with genetically encoded sensors and modulators. Pal A, Tian L Current opinion in chemical biology 32823064 Curr Opin Chem Biol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32823064
Monitoring activity in neural circuits with genetically encoded indicators. Broussard GJ, Liang R, Tian L Frontiers in molecular neuroscience 25538558 Front Mol Neurosci 2014 https://www.ncbi.nlm.nih.gov/pubmed/25538558
SynQuant: an automatic tool to quantify synapses from microscopy images. Wang Y, Wang C, Ranefall P, Broussard GJ, Wang Y, Shi G, Lyu B, Wu CT, Wang Y, Tian L, Yu G Bioinformatics (Oxford, England) 31596456 Bioinformatics 2020 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/31596456
Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance. Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tsuboi T, Kitaguchi T, Tian L, McHugh TJ, Hirase H Nature communications 31980655 Nat Commun 2020 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/31980655
Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor. Salinas AG, Lee JO, Augustin SM, Zhang S, Patriarchi T, Tian L, Morales M, Mateo Y, Lovinger DM Nature communications 37739964 Nat Commun 2023 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/37739964
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L Cell reports 29996097 Cell Rep 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29996097
Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1. Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V eLife 31545171 Elife 2019 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/31545171
A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System. de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S Neuron 30503173 Neuron 2019 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/30503173
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L Cell 33333022 Cell 2020 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/33333022
Imaging chemical neurotransmission with genetically encoded fluorescent sensors. Liang R, Broussard GJ, Tian L ACS chemical neuroscience 25565280 ACS Chem Neurosci 2015 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/25565280
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J Nature chemical biology 32989297 Nat Chem Biol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32989297
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Psychedelic-inspired drug discovery using an engineered biosensor. Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L Cell 33915107 Cell 2021 May 13 https://www.ncbi.nlm.nih.gov/pubmed/33915107
In vivo measurement of afferent activity with axon-specific calcium imaging. Broussard GJ, Liang Y, Fridman M, Unger EK, Meng G, Xiao X, Ji N, Petreanu L, Tian L Nature neuroscience 30127424 Nat Neurosci 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30127424
Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. Corre J, van Zessen R, Loureiro M, Patriarchi T, Tian L, Pascoli V, Lüscher C eLife 30373717 Elife 2018 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/30373717
Maps of neuronal activity across the mouse brain. Andreoni A, Tian L Nature biomedical engineering 31073176 Nat Biomed Eng 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31073176
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Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L Nature cell biology 29695787 Nat Cell Biol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29695787
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The HOPE Pilot Study: Harnessing Patient-Reported Outcomes and Biometric Data to Enhance Cancer Care. Wright AA, Raman N, Staples P, Schonholz S, Cronin A, Carlson K, Keating NL, Onnela JP JCO clinical cancer informatics 30652585 JCO Clin Cancer Inform 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30652585
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Characterizing the clinical relevance of digital phenotyping data quality with applications to a cohort with schizophrenia. Torous J, Staples P, Barnett I, Sandoval LR, Keshavan M, Onnela JP NPJ digital medicine 31304300 NPJ Digit Med 2018 https://www.ncbi.nlm.nih.gov/pubmed/31304300
Precision Assessment of Real-World Associations Between Stress and Sleep Duration Using Actigraphy Data Collected Continuously for an Academic Year: Individual-Level Modeling Study. Vidal Bustamante CM, Coombs Iii G, Rahimi-Eichi H, Mair P, Onnela JP, Baker JT, Buckner RL JMIR formative research 38687600 JMIR Form Res 2024 Apr 30 https://www.ncbi.nlm.nih.gov/pubmed/38687600
Utilizing a Personal Smartphone Custom App to Assess the Patient Health Questionnaire-9 (PHQ-9) Depressive Symptoms in Patients With Major Depressive Disorder. Torous J, Staples P, Shanahan M, Lin C, Peck P, Keshavan M, Onnela JP JMIR mental health 26543914 JMIR Ment Health 2015 Jan-Mar https://www.ncbi.nlm.nih.gov/pubmed/26543914
Realizing the potential of mobile mental health: new methods for new data in psychiatry. Torous J, Staples P, Onnela JP Current psychiatry reports 26073363 Curr Psychiatry Rep 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26073363
Beyond smartphones and sensors: choosing appropriate statistical methods for the analysis of longitudinal data. Barnett I, Torous J, Staples P, Keshavan M, Onnela JP Journal of the American Medical Informatics Association : JAMIA 30272176 J Am Med Inform Assoc 2018 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/30272176
Inferring mobility measures from GPS traces with missing data. Barnett I, Onnela JP Biostatistics (Oxford, England) 30371736 Biostatistics 2020 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/30371736
Sociodemographic characteristics of missing data in digital phenotyping. Kiang MV, Chen JT, Krieger N, Buckee CO, Alexander MJ, Baker JT, Buckner RL, Coombs G 3rd, Rich-Edwards JW, Carlson KW, Onnela JP Scientific reports 34326370 Sci Rep 2021 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/34326370
A comparison of passive and active estimates of sleep in a cohort with schizophrenia. Staples P, Torous J, Barnett I, Carlson K, Sandoval L, Keshavan M, Onnela JP NPJ schizophrenia 29038553 NPJ Schizophr 2017 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/29038553
Methodology and Reporting of Mobile Heath and Smartphone Application Studies for Schizophrenia. Torous J, Firth J, Mueller N, Onnela JP, Baker JT Harvard review of psychiatry 28234658 Harv Rev Psychiatry 2017 May/Jun https://www.ncbi.nlm.nih.gov/pubmed/28234658
Digital Phenotyping to Quantify Psychosocial Well-Being Trajectories After Spinal Cord Injury. Mercier HW, Hamner JW, Torous J, Onnela JP, Taylor JA American journal of physical medicine & rehabilitation 32576743 Am J Phys Med Rehabil 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32576743
Augmented Movelet Method for Activity Classification Using Smartphone Gyroscope and Accelerometer Data. Huang EJ, Onnela JP Sensors (Basel, Switzerland) 32630752 Sensors (Basel) 2020 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/32630752
Smartphone-based Assessment of Preoperative Decision Conflict and Postoperative Physical Activity Among Patients Undergoing Cancer Surgery: A Prospective Cohort Study. Panda N, Solsky I, Cauley CE, Lipsitz S, Desai EV, Huang EJ, Benjamin EM, Lubitz CC, Onnela JP, Haynes AB Annals of surgery 32941270 Ann Surg 2022 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/32941270
New dimensions and new tools to realize the potential of RDoC: digital phenotyping via smartphones and connected devices. Torous J, Onnela JP, Keshavan M Translational psychiatry 28267146 Transl Psychiatry 2017 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/28267146
Design and results of a smartphone-based digital phenotyping study to quantify ALS progression. Berry JD, Paganoni S, Carlson K, Burke K, Weber H, Staples P, Salinas J, Chan J, Green JR, Connaghan K, Barback J, Onnela JP Annals of clinical and translational neurology 31139685 Ann Clin Transl Neurol 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31139685
Smartphone-Based Tracking of Sleep in Depression, Anxiety, and Psychotic Disorders. Aledavood T, Torous J, Triana Hoyos AM, Naslund JA, Onnela JP, Keshavan M Current psychiatry reports 31161412 Curr Psychiatry Rep 2019 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/31161412
Open-source Longitudinal Sleep Analysis From Accelerometer Data (DPSleep): Algorithm Development and Validation. Rahimi-Eichi H, Coombs Iii G, Vidal Bustamante CM, Onnela JP, Baker JT, Buckner RL JMIR mHealth and uHealth 34612831 JMIR Mhealth Uhealth 2021 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/34612831
High potential but limited evidence: Using voice data from smartphones to monitor and diagnose mood disorders. Or F, Torous J, Onnela JP Psychiatric rehabilitation journal 28891659 Psychiatr Rehabil J 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28891659
Relapse prediction in schizophrenia through digital phenotyping: a pilot study. Barnett I, Torous J, Staples P, Sandoval L, Keshavan M, Onnela JP Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 29511333 Neuropsychopharmacology 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29511333
Expected Versus Experienced Health-Related Quality of Life Among Patients Recovering From Cancer Surgery: A Prospective Cohort Study. Panda N, Solsky I, Neal BJ, Hawrusik B, Lipsitz S, Lubitz CC, Gibbons C, Brindle M, Sinyard RD, Onnela JP, Cauley CE, Haynes AB Annals of surgery open : perspectives of surgical history, education, and clinical approaches 34179891 Ann Surg Open 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34179891
Estimating longitudinal depressive symptoms from smartphone data in a transdiagnostic cohort. Pellegrini AM, Huang EJ, Staples PC, Hart KL, Lorme JM, Brown HE, Perlis RH, Onnela JJ Brain and behavior 35076166 Brain Behav 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35076166
Harnessing Smartphone-Based Digital Phenotyping to Enhance Behavioral and Mental Health. Onnela JP, Rauch SL Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 26818126 Neuropsychopharmacology 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26818126
A crossroad for validating digital tools in schizophrenia and mental health. Torous J, Staples P, Barnett I, Onnela JP, Keshavan M NPJ schizophrenia 29626190 NPJ Schizophr 2018 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/29626190
Understanding the quality, effectiveness and attributes of top-rated smartphone health apps. Wisniewski H, Liu G, Henson P, Vaidyam A, Hajratalli NK, Onnela JP, Torous J Evidence-based mental health 30635262 Evid Based Ment Health 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30635262
EndNote: Feature-based classification of networks. Barnett I, Malik N, Kuijjer ML, Mucha PJ, Onnela JP Network science (Cambridge University Press) 31984135 Netw Sci (Camb Univ Press) 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31984135
The relationship of rate and pause features to the communicative participation of people living with ALS. Connaghan KP, Green JR, Eshghi M, Haenssler AE, Scheier ZA, Clark A, Iyer A, Richburg BD, Rowe HP, Okada J, Johnson SA, Onnela JP, Burke KM, Berry JD Muscle & nerve 38837773 Muscle Nerve 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38837773
The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System. Cholewa-Waclaw J, Bird A, von Schimmelmann M, Schaefer A, Yu H, Song H, Madabhushi R, Tsai LH The Journal of neuroscience : the official journal of the Society for Neuroscience 27911745 J Neurosci 2016 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/27911745
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. von Schimmelmann M, Feinberg PA, Sullivan JM, Ku SM, Badimon A, Duff MK, Wang Z, Lachmann A, Dewell S, Ma'ayan A, Han MH, Tarakhovsky A, Schaefer A Nature neuroscience 27526204 Nat Neurosci 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27526204
A comparative analysis of microglial inducible Cre lines. Faust TE, Feinberg PA, O'Connor C, Kawaguchi R, Chan A, Strasburger H, Frosch M, Boyle MA, Masuda T, Amann L, Knobeloch KP, Prinz M, Schaefer A, Schafer DP Cell reports 37635351 Cell Rep 2023 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/37635351
MicroRNA-128 governs neuronal excitability and motor behavior in mice. Tan CL, Plotkin JL, Venø MT, von Schimmelmann M, Feinberg P, Mann S, Handler A, Kjems J, Surmeier DJ, O'Carroll D, Greengard P, Schaefer A Science (New York, N.Y.) 24311694 Science 2013 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/24311694
Convergence of spectrums: neuronal gene network states in autism spectrum disorder. Sullivan JM, De Rubeis S, Schaefer A Current opinion in neurobiology 31220745 Curr Opin Neurobiol 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31220745
Microglia states and nomenclature: A field at its crossroads. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T Neuron 36327895 Neuron 2022 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/36327895
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Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice. Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A The Journal of experimental medicine 26392221 J Exp Med 2015 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/26392221
Argonaute-associated short introns are a novel class of gene regulators. Hansen TB, Venø MT, Jensen TI, Schaefer A, Damgaard CK, Kjems J Nature communications 27173734 Nat Commun 2016 May 13 https://www.ncbi.nlm.nih.gov/pubmed/27173734
CSF-1 controls cerebellar microglia and is required for motor function and social interaction. Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M The Journal of experimental medicine 31350310 J Exp Med 2019 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/31350310
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Negative feedback control of neuronal activity by microglia. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A Nature 32999463 Nature 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32999463
Epigenetic regulation of brain region-specific microglia clearance activity. Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh YE, Ebert A, Pimenova AA, Ramirez BR, Chan AT, Sullivan JM, Purushothaman I, Scarpa JR, Goate AM, Busslinger M, Shen L, Losic B, Schaefer A Nature neuroscience 30038282 Nat Neurosci 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30038282
An AUTS2-Polycomb complex activates gene expression in the CNS. Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D Nature 25519132 Nature 2014 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/25519132
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. Brumback AC, Ellwood IT, Kjaerby C, Iafrati J, Robinson S, Lee AT, Patel T, Nagaraj S, Davatolhagh F, Sohal VS Molecular psychiatry 29112191 Mol Psychiatry 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29112191
Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. Southwell DG, Seifikar H, Malik R, Lavi K, Vogt D, Rubenstein JL, Sohal VS The Journal of neuroscience : the official journal of the Society for Neuroscience 31988060 J Neurosci 2020 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/31988060
Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures. Khoshkhoo S, Vogt D, Sohal VS Neuron 28041880 Neuron 2017 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/28041880
Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Cho KK, Hoch R, Lee AT, Patel T, Rubenstein JL, Sohal VS Neuron 25754826 Neuron 2015 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/25754826
Roles of Prefrontal Cortex and Mediodorsal Thalamus in Task Engagement and Behavioral Flexibility. Marton TF, Seifikar H, Luongo FJ, Lee AT, Sohal VS The Journal of neuroscience : the official journal of the Society for Neuroscience 29437889 J Neurosci 2018 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/29437889
Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity. Luongo FJ, Zimmerman CA, Horn ME, Sohal VS Journal of neurophysiology 26888108 J Neurophysiol 2016 May 1 https://www.ncbi.nlm.nih.gov/pubmed/26888108
The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Vogt D, Cho KKA, Lee AT, Sohal VS, Rubenstein JLR Cell reports 25937288 Cell Rep 2015 May 12 https://www.ncbi.nlm.nih.gov/pubmed/25937288
Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs. Kjaerby C, Athilingam J, Robinson SE, Iafrati J, Sohal VS Cell reports 27974203 Cell Rep 2016 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/27974203
Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies. Ellwood IT, Patel T, Wadia V, Lee AT, Liptak AT, Bender KJ, Sohal VS The Journal of neuroscience : the official journal of the Society for Neuroscience 28739583 J Neurosci 2017 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/28739583
Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS Neuron 31030955 Neuron 2019 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/31030955
Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal VS Neuron 24361076 Neuron 2014 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/24361076
Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. Luongo FJ, Horn ME, Sohal VS Biological psychiatry 26022075 Biol Psychiatry 2016 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/26022075
VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks. Lee AT, Cunniff MM, See JZ, Wilke SA, Luongo FJ, Ellwood IT, Ponnavolu S, Sohal VS Neuron 31053407 Neuron 2019 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/31053407
Network Effects of the 15q13.3 Microdeletion on the Transcriptome and Epigenome in Human-Induced Neurons. Zhang S, Zhang X, Purmann C, Ma S, Shrestha A, Davis KN, Ho M, Huang Y, Pattni R, Wong WH, Bernstein JA, Hallmayer J, Urban AE Biological psychiatry 32919612 Biol Psychiatry 2021 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/32919612
Local and global chromatin interactions are altered by large genomic deletions associated with human brain development. Zhang X, Zhang Y, Zhu X, Purmann C, Haney MS, Ward T, Khechaduri A, Yao J, Weissman SM, Urban AE Nature communications 30559385 Nat Commun 2018 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/30559385
Mutations in human DNA methyltransferase DNMT1 induce specific genome-wide epigenomic and transcriptomic changes in neurodevelopment. Davis KN, Qu PP, Ma S, Lin L, Plastini M, Dahl N, Plazzi G, Pizza F, O'Hara R, Wong WH, Hallmayer J, Mignot E, Zhang X, Urban AE Human molecular genetics 37584462 Hum Mol Genet 2023 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/37584462
Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs. Ward TR, Qu PP, Leung LC, Zhou B, Muench KL, Khechaduri A, Plastini MJ, Charlton CA, Pattni R, Ho S, Ho M, Huang Y, Zhou P, Hallmayer JF, Mourrain P, Palmer TD, Zhang X, Urban AE European journal of human genetics : EJHG 40374944 Eur J Hum Genet 2025 May 15 https://www.ncbi.nlm.nih.gov/pubmed/40374944
Comprehensive performance comparison of high-resolution array platforms for genome-wide Copy Number Variation (CNV) analysis in humans. Haraksingh RR, Abyzov A, Urban AE BMC genomics 28438122 BMC Genomics 2017 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/28438122
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders. Li J, Ma Z, Shi M, Malty RH, Aoki H, Minic Z, Phanse S, Jin K, Wall DP, Zhang Z, Urban AE, Hallmayer J, Babu M, Snyder M Cell systems 26949739 Cell Syst 2015 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/26949739
Resolving the 22q11.2 deletion using CTLR-Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints. Zhou B, Purmann C, Guo H, Shin G, Huang Y, Pattni R, Meng Q, Greer SU, Roychowdhury T, Wood RN, Ho M, Dohna HZ, Abyzov A, Hallmayer JF, Wong WH, Ji HP, Urban AE Proceedings of the National Academy of Sciences of the United States of America 39042694 Proc Natl Acad Sci U S A 2024 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/39042694
Seizure Action Plans Do Not Reduce Health Care Utilization in Pediatric Epilepsy Patients. Roundy LM, Filloux FM, Kerr L, Rimer A, Bonkowsky JL Journal of child neurology 26245799 J Child Neurol 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26245799
Targeted leukodystrophy diagnosis based on charges and yields for testing. Richards J, Korgenski EK, Taft RJ, Vanderver A, Bonkowsky JL American journal of medical genetics. Part A 26183797 Am J Med Genet A 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26183797
Microfluidic-aided genotyping of zebrafish in the first 48 h with 100% viability. Samuel R, Stephenson R, Roy P, Pryor R, Zhou L, Bonkowsky JL, Gale BK Biomedical microdevices 25773537 Biomed Microdevices 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25773537
Whole-genome analysis for effective clinical diagnosis and gene discovery in early infantile epileptic encephalopathy. Ostrander BEP, Butterfield RJ, Pedersen BS, Farrell AJ, Layer RM, Ward A, Miller C, DiSera T, Filloux FM, Candee MS, Newcomb T, Bonkowsky JL, Marth GT, Quinlan AR NPJ genomic medicine 30109124 NPJ Genom Med 2018 https://www.ncbi.nlm.nih.gov/pubmed/30109124
Neonatal Magnesium Levels Between 24 and 48 Hours of Life and Outcomes for Epilepsy and Motor Impairment in Premature Infants. Ostrander B, Bardsley T, Korgenski EK, Greene T, Bonkowsky JL Pediatric neurology 27025188 Pediatr Neurol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27025188
Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure. Dukes AA, Bai Q, Van Laar VS, Zhou Y, Ilin V, David CN, Agim ZS, Bonkowsky JL, Cannon JR, Watkins SC, Croix CM, Burton EA, Berman SB Neurobiology of disease 27452482 Neurobiol Dis 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27452482
Chiari I Malformation Causing Developmental Regression in a 4 Month Old. Doll ES, Bonkowsky JL, Brown LL, de Havenon AH, Brockmeyer DL, Glasgow TS, Morita DC Global pediatric health.. 27335920 Glob Pediatr Health 2014 https://www.ncbi.nlm.nih.gov/pubmed/27335920
Costs of the diagnostic odyssey in children with inherited leukodystrophies. Richards J, Korgenski EK, Srivastava R, Bonkowsky JL Neurology 26320197 Neurology 2015 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/26320197
A Serotonin Circuit Acts as an Environmental Sensor to Mediate Midline Axon Crossing through EphrinB2. Xing L, Son JH, Stevenson TJ, Lillesaar C, Bally-Cuif L, Dahl T, Bonkowsky JL The Journal of neuroscience : the official journal of the Society for Neuroscience 26538650 J Neurosci 2015 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/26538650
The Midline Axon Crossing Decision Is Regulated through an Activity-Dependent Mechanism by the NMDA Receptor. Gao J, Stevenson TJ, Douglass AD, Barrios JP, Bonkowsky JL eNeuro 29766040 eNeuro 2018 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/29766040
Intrapartum magnesium sulfate and the potential for cardiopulmonary drug-drug interactions. Campbell SC, Stockmann C, Balch A, Clark EA, Kamyar M, Varner M, Korgenski EK, Bonkowsky JL, Spigarelli MG, Sherwin CM Therapeutic drug monitoring 24487252 Ther Drug Monit 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24487252
Determinants of health care use in a population-based leukodystrophy cohort. Nelson C, Mundorff MB, Korgenski EK, Brimley CJ, Srivastava R, Bonkowsky JL The Journal of pediatrics 23069195 J Pediatr 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23069195
Expression of arginine vasotocin receptors in the developing zebrafish CNS. Iwasaki K, Taguchi M, Bonkowsky JL, Kuwada JY Gene expression patterns : GEP 23830982 Gene Expr Patterns 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23830982
Temporal Dysynchrony in brain connectivity gene expression following hypoxia. Milash B, Gao J, Stevenson TJ, Son JH, Dahl T, Bonkowsky JL BMC genomics 27146468 BMC Genomics 2016 May 4 https://www.ncbi.nlm.nih.gov/pubmed/27146468
A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity. Chen YC, Semenova S, Rozov S, Sundvik M, Bonkowsky JL, Panula P The Journal of biological chemistry 27539857 J Biol Chem 2016 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/27539857
Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling. Duncan RN, Xie Y, McPherson AD, Taibi AV, Bonkowsky JL, Douglass AD, Dorsky RI Development (Cambridge, England) 26603385 Development 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26603385
An automated system for rapid cellular extraction from live zebrafish embryos and larvae: Development and application to genotyping. Lambert CJ, Freshner BC, Chung A, Stevenson TJ, Bowles DM, Samuel R, Gale BK, Bonkowsky JL PloS one 29543903 PLoS One 2018 https://www.ncbi.nlm.nih.gov/pubmed/29543903
Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation. McPherson AD, Barrios JP, Luks-Morgan SJ, Manfredi JP, Bonkowsky JL, Douglass AD, Dorsky RI Current biology : CB 26774784 Curr Biol 2016 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/26774784
Rapid and efficient zebrafish genotyping using PCR with high-resolution melt analysis. Xing L, Quist TS, Stevenson TJ, Dahlem TJ, Bonkowsky JL Journal of visualized experiments : JoVE 24561516 J Vis Exp 2014 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/24561516
Maternal magnesium sulphate exposure predicts neonatal magnesium blood concentrations. Sherwin CM, Balch A, Campbell SC, Fredrickson J, Clark EA, Varner M, Stockmann C, Korgenski EK, Bonkowsky JL, Spigarelli MG Basic & clinical pharmacology & toxicology 24164968 Basic Clin Pharmacol Toxicol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24164968
National variation in costs and mortality for leukodystrophy patients in US children's hospitals. Brimley CJ, Lopez J, van Haren K, Wilkes J, Sheng X, Nelson C, Korgenski EK, Srivastava R, Bonkowsky JL Pediatric neurology 23953952 Pediatr Neurol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23953952
Dopaminergic Co-Regulation of Locomotor Development and Motor Neuron Synaptogenesis is Uncoupled by Hypoxia in Zebrafish. Son JH, Stevenson TJ, Bowles MD, Scholl EA, Bonkowsky JL eNeuro 32001551 eNeuro 2020 Jan/Feb https://www.ncbi.nlm.nih.gov/pubmed/32001551
A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination. Strachan LR, Stevenson TJ, Freshner B, Keefe MD, Miranda Bowles D, Bonkowsky JL Human molecular genetics 28911205 Hum Mol Genet 2017 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/28911205
Autism Spectrum Disorder and Neonatal Serum Magnesium Levels in Preterm Infants. Bakian AV, Bilder DA, Korgenski EK, Bonkowsky JL Child neurology open 30246047 Child Neurol Open 2018 https://www.ncbi.nlm.nih.gov/pubmed/30246047
Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Schweitzer J, Löhr H, Bonkowsky JL, Hübscher K, Driever W Development (Cambridge, England) 23222439 Development 2013 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/23222439
Preventable Infections in Children with Leukodystrophy. Anderson HM, Wilkes J, Korgenski EK, Pulsipher MA, Blaschke AJ, Hersh AL, Srivastava R, Bonkowsky JL Annals of clinical and translational neurology 24955379 Ann Clin Transl Neurol 2014 May 1 https://www.ncbi.nlm.nih.gov/pubmed/24955379
Congenital lethal motor neuron disease with a novel defect in ribosome biogenesis. Butterfield RJ, Stevenson TJ, Xing L, Newcomb TM, Nelson B, Zeng W, Li X, Lu HM, Lu H, Farwell Gonzalez KD, Wei JP, Chao EC, Prior TW, Snyder PJ, Bonkowsky JL, Swoboda KJ Neurology 24647030 Neurology 2014 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/24647030
The conserved dopaminergic diencephalospinal tract mediates vertebrate locomotor development in zebrafish larvae. Lambert AM, Bonkowsky JL, Masino MA The Journal of neuroscience : the official journal of the Society for Neuroscience 23015438 J Neurosci 2012 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/23015438
Disease specific therapies in leukodystrophies and leukoencephalopathies. Helman G, Van Haren K, Bonkowsky JL, Bernard G, Pizzino A, Braverman N, Suhr D, Patterson MC, Ali Fatemi S, Leonard J, van der Knaap MS, Back SA, Damiani S, Goldman SA, Takanohashi A, Petryniak M, Rowitch D, Messing A, Wrabetz L, Schiffmann R, Eichler F, Escolar ML, Vanderver A, GLIA Consortium Molecular genetics and metabolism 25684057 Mol Genet Metab 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25684057
Revised consensus statement on the preventive and symptomatic care of patients with leukodystrophies. Adang LA, Sherbini O, Ball L, Bloom M, Darbari A, Amartino H, DiVito D, Eichler F, Escolar M, Evans SH, Fatemi A, Fraser J, Hollowell L, Jaffe N, Joseph C, Karpinski M, Keller S, Maddock R, Mancilla E, McClary B, Mertz J, Morgart K, Langan T, Leventer R, Parikh S, Pizzino A, Prange E, Renaud DL, Rizzo W, Shapiro J, Suhr D, Suhr T, Tonduti D, Waggoner J, Waldman A, Wolf NI, Zerem A, Bonkowsky JL, Bernard G, van Haren K, Vanderver A, Global Leukodystrophy Initiative (GLIA) Consortium Molecular genetics and metabolism 28863857 Mol Genet Metab 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28863857
Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons. Son JH, Keefe MD, Stevenson TJ, Barrios JP, Anjewierden S, Newton JB, Douglass AD, Bonkowsky JL Scientific reports 26728131 Sci Rep 2016 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/26728131
Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. Sivachenko A, Gordon HB, Kimball SS, Gavin EJ, Bonkowsky JL, Letsou A Disease models & mechanisms 26893370 Dis Model Mech 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26893370
Rapid clinical diagnostic variant investigation of genomic patient sequencing data with iobio web tools. Ward A, Karren MA, Di Sera T, Miller C, Velinder M, Qiao Y, Filloux FM, Ostrander B, Butterfield R, Bonkowsky JL, Dere W, Marth GT Journal of clinical and translational science 29707261 J Clin Transl Sci 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29707261
Clinical exome sequencing identifies a novel TUBB4A mutation in a child with static hypomyelinating leukodystrophy. Purnell SM, Bleyl SB, Bonkowsky JL Pediatric neurology 24742798 Pediatr Neurol 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24742798
Neonatal magnesium levels correlate with motor outcomes in premature infants: a long-term retrospective cohort study. Doll E, Wilkes J, Cook LJ, Korgenski EK, Faix RG, Yoder BA, Srivastava R, Sherwin CM, Spigarelli MG, Clark EA, Bonkowsky JL Frontiers in pediatrics 25414842 Front Pediatr 2014 https://www.ncbi.nlm.nih.gov/pubmed/25414842
Closing delivery gaps in the treatment of tuberculosis infection: Lessons from implementation research in Peru. Yuen CM, Millones AK, Puma D, Jimenez J, Galea JT, Calderon R, Pages GS, Brooks MB, Lecca L, Nicholson T, Becerra MC, Keshavjee S PloS one 33606824 PLoS One 2021 https://www.ncbi.nlm.nih.gov/pubmed/33606824
Identifying barriers and facilitators to implementation of community-based tuberculosis active case finding with mobile X-ray units in Lima, Peru: a RE-AIM evaluation. Yuen CM, Puma D, Millones AK, Galea JT, Tzelios C, Calderon RI, Brooks MB, Jimenez J, Contreras C, Nichols TC, Nicholson T, Lecca L, Becerra MC, Keshavjee S BMJ open 34234000 BMJ Open 2021 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/34234000
The impact of the COVID-19 pandemic on patients' experiences obtaining a tuberculosis diagnosis in Peru: a mixed-methods study. Millones AK, Lecca L, Acosta D, Campos H, Del Águila-Rojas E, Farroñay S, Morales G, Ramirez-Sandoval J, Torres I, Jimenez J, Yuen CM BMC infectious diseases 36352374 BMC Infect Dis 2022 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/36352374
Barriers and facilitators to tuberculosis diagnosis in Lima, Peru: a mixed methods study. Geadas C, Millones AK, Acosta D, Campos H, Del Aguila-Rojas E, Farroñay S, Morales G, Ramirez-Sandoval J, Torres I, Jimenez J, Lecca L, Yuen CM BMC infectious diseases 39118040 BMC Infect Dis 2024 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/39118040
A role for community-level socioeconomic indicators in targeting tuberculosis screening interventions. Brooks MB, Jenkins HE, Puma D, Tzelios C, Millones AK, Jimenez J, Galea JT, Lecca L, Becerra MC, Keshavjee S, Yuen CM Scientific reports 35039612 Sci Rep 2022 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/35039612
Geographic accessibility to health facilities predicts uptake of community-based tuberculosis screening in an urban setting. Jenkins HE, Ayuk S, Puma D, Brooks MB, Millones AK, Jimenez J, Lecca L, Galea JT, Becerra M, Keshavjee S, Yuen CM International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 35470023 Int J Infect Dis 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35470023
Mapping local hot spots with routine tuberculosis data: A pragmatic approach to identify spatial variability. Brooks MB, Millones AK, Puma D, Contreras C, Jimenez J, Tzelios C, Jenkins HE, Yuen CM, Keshavjee S, Lecca L, Becerra MC PloS one 35324987 PLoS One 2022 https://www.ncbi.nlm.nih.gov/pubmed/35324987
Toward patient-centered tuberculosis preventive treatment: preferences for regimens and formulations in Lima, Peru. Yuen CM, Millones AK, Galea JT, Puma D, Jimenez J, Lecca L, Becerra MC, Keshavjee S BMC public health 33430823 BMC Public Health 2021 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/33430823
Impact of the private sector on spatial accessibility to chest radiography services in Lima, Peru. Xiong Y, Millones AK, Farroñay S, Torres I, Acosta D, Jordan DR, Jimenez J, Wippel C, Jenkins HE, Lecca L, Yuen CM IJTLD open 38698907 IJTLD Open 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/38698907
Exploring the Role of the Private Sector in Tuberculosis Detection and Management in Lima, Peru: A Mixed-Methods Patient Pathway Analysis. Wippel C, Farroñay S, Gilbert HN, Millones AK, Acosta D, Torres I, Jimenez J, Alarcón VA, Lecca L, Yuen CM The American journal of tropical medicine and hygiene 38744270 Am J Trop Med Hyg 2024 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/38744270
Adapting a mobile TB screening unit to provide integrated screening services and linkage to primary care. Millones AK, Cohen S, Acosta D, Campos H, Condeso A, Farroñay S, Torres I, Vargas C, Abanto K, Contreras C, Palomino S, Jimenez J, Lecca L, Yuen CM Public health action 39618835 Public Health Action 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39618835
Geospatial analysis of reported activity locations to identify sites for tuberculosis screening. Yuen CM, Brooks MB, Millones AK, Acosta D, Del Águila-Rojas E, Campos H, Farroñay S, Morales G, Ramirez-Sandoval J, Nichols TC, Jimenez J, Jenkins HE, Lecca L Scientific reports 35982104 Sci Rep 2022 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/35982104
Exploring the role of the private sector in tuberculosis detection and management in Lima, Peru: a mixed-methods patient pathway analysis. Wippel C, Farroñay S, Gilbert HN, Millones AK, Acosta D, Torres I, Jimenez J, Lecca L, Yuen CM medRxiv : the preprint server for health sciences 37808756 medRxiv 2023 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/37808756
Utility of Mycobacterium tuberculosis Genome Sequencing Snapshots to Assess Transmission Dynamics Over Time. Yuen CM, Huang CC, Millones AK, Calderon RI, Manson AL, Jimenez J, Contreras C, Earl AM, Becerra MC, Lecca L, Murray MB The Journal of infectious diseases 37995298 J Infect Dis 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/37995298
Person-centered strategies for delivering TB diagnostic services in Lima, Peru. Yuen CM, Millones AK, Acosta D, Torres I, Farroñay S, Jimenez J, Lecca L Public health action 37736576 Public Health Action 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37736576
A preliminary investigation of attachment style and inflammation in African-American young adults. Ehrlich KB, Stern JA, Eccles J, Dinh JV, Hopper EA, Kemeny ME, Adam EK, Cassidy J Attachment & human development 30406721 Attach Hum Dev 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30406721
Maltreatment exposure across childhood and low-grade inflammation: Considerations of exposure type, timing, and sex differences. Ehrlich KB, Miller GE, Rogosch FA, Cicchetti D Developmental psychobiology 32896910 Dev Psychobiol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/32896910
Exposure to parental depression in adolescence and proinflammatory phenotypes 20 years later. Ehrlich KB, Celia-Sanchez ML, Yu T, Heard-Garris N, Chen E, Miller GE, Brody GH Brain, behavior, and immunity 38242368 Brain Behav Immun 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38242368
The protective role of parental vigilance in the link between risky childhood environments and health. Corallo KL, Carr CP, Lavner JA, Koss KJ, Ehrlich KB Social science & medicine (1982) 36527897 Soc Sci Med 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36527897
Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial. Brody GH, Yu T, Miller GE, Ehrlich KB, Chen E Journal of child psychology and psychiatry, and allied disciplines 30203840 J Child Psychol Psychiatry 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30203840
Attachment and physical health: introduction to the special issue. B Ehrlich K, Cassidy J Attachment & human development 30406722 Attach Hum Dev 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30406722
Emotional Distress, Targeted Rejection, and Antibody Production After Influenza Vaccination in Adolescence. Corallo KL, Lyle SM, Carlock MA, Ross TM, Ehrlich KB Psychosomatic medicine 35100185 Psychosom Med 2022 May 1 https://www.ncbi.nlm.nih.gov/pubmed/35100185
How does the social world shape health across the lifespan? Insights and new directions. Ehrlich KB The American psychologist 33382288 Am Psychol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33382288
Changes in depressive symptoms and antibody production following influenza vaccination in adolescents and adults. Ehrlich KB, Lyle SM, Corallo KL, Lavner JA, Ross TM Vaccine 38702230 Vaccine 2024 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/38702230
Socioeconomic disadvantage and high-effort coping in childhood: evidence of skin-deep resilience. Ehrlich KB, Lyle SM, Corallo KL, Brisson JM, Wiggins ER, Yu T, Chen E, Miller GE, Brody GH Journal of child psychology and psychiatry, and allied disciplines 37246563 J Child Psychol Psychiatry 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/37246563
Recalled Neighborhood Environments, Parental Control, and Cytokine-Mediated Response to Viral Challenge. Corallo KL, Lyle SM, Murphy MLM, vanDellen MR, Ehrlich KB Psychosomatic medicine 34334728 Psychosom Med 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34334728
Neighborhood poverty, allostatic load, and changes in cellular aging in African American young adults: the moderating role of attachment. Ehrlich KB, Yu T, Sadiq A, Brody GH Attachment & human development 34617499 Attach Hum Dev 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/34617499
Beyond Early Adversity: The Role of Parenting in Infant Physical Health. Stern JA, Beijers R, Ehrlich KB, Cassidy J, de Weerth C Journal of developmental and behavioral pediatrics : JDBP 32271266 J Dev Behav Pediatr 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32271266
Harsh parenting and youth systemic inflammation: Modulation by the autonomic nervous system. Oshri A, Duprey EB, Liu S, Ehrlich KB Health psychology : official journal of the Division of Health Psychology, American Psychological Association 32202827 Health Psychol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32202827
Attachment and psychoneuroimmunology. Ehrlich KB Current opinion in psychology 29631123 Curr Opin Psychol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/29631123
The Profundity of the Everyday: Family Routines in Adolescence Predict Development in Young Adulthood. Barton AW, Brody GH, Yu T, Kogan SM, Chen E, Ehrlich KB The Journal of adolescent health : official publication of the Society for Adolescent Medicine 30392861 J Adolesc Health 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30392861
The benefits of nurturant-involved parenting for children's internalizing symptoms and cardiometabolic health in high-risk contexts. Wiggins ER, Brisson JM, Lavner JA, Ehrlich KB Development and psychopathology 37386849 Dev Psychopathol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37386849
Ethical Machine Learning in Healthcare. Chen IY, Pierson E, Rose S, Joshi S, Ferryman K, Ghassemi M Annual review of biomedical data science 34396058 Annu Rev Biomed Data Sci 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34396058
Improving the Performance of Risk Adjustment Systems: Constrained Regressions, Reinsurance, and Variable Selection. McGuire TG, Zink AL, Rose S American journal of health economics 34869790 Am J Health Econ 2021 Fall https://www.ncbi.nlm.nih.gov/pubmed/34869790
Fair regression for health care spending. Zink A, Rose S Biometrics 31860120 Biometrics 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/31860120
Uncertainty in lung cancer stage for survival estimation via set-valued classification. Bergquist S, Brooks GA, Landrum MB, Keating NL, Rose S Statistics in medicine 35675972 Stat Med 2022 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/35675972
Data Source Concordance for Infectious Disease Epidemiology. Majumder M, Cusick MM, Rose S medRxiv : the preprint server for health sciences 35677068 medRxiv 2022 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/35677068
Causal inference in high dimensions: A marriage between Bayesian modeling and good frequentist properties. Antonelli J, Papadogeorgou G, Dominici F Biometrics 33349923 Biometrics 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/33349923
Measuring concordance of data sources used for infectious disease research in the USA: a retrospective data analysis. Majumder MS, Cusick M, Rose S BMJ open 36854597 BMJ Open 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/36854597
Conditional cross-design synthesis estimators for generalizability in Medicaid. Degtiar I, Layton T, Wallace J, Rose S Biometrics 37018228 Biometrics 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37018228
CAUSAL INFERENCE IN THE CONTEXT OF AN ERROR PRONE EXPOSURE: AIR POLLUTION AND MORTALITY. Wu X, Braun D, Kioumourtzoglou MA, Choirat C, Di Q, Dominici F The annals of applied statistics 31649797 Ann Appl Stat 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/31649797
Considerations for outcome-dependent biased sampling in health databases. Rose S Statistics in medicine 31489684 Stat Med 2019 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/31489684
Air pollution exposure disparities across US population and income groups. Jbaily A, Zhou X, Liu J, Lee TH, Kamareddine L, Verguet S, Dominici F Nature 35022594 Nature 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/35022594
A generalizable data assembly algorithm for infectious disease outbreaks. Majumder MS, Rose S JAMIA open 34350393 JAMIA Open 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34350393
Reflection on modern methods: when worlds collide-prediction, machine learning and causal inference. Blakely T, Lynch J, Simons K, Bentley R, Rose S International journal of epidemiology 31298274 Int J Epidemiol 2021 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/31298274
Intersections of machine learning and epidemiological methods for health services research. Rose S International journal of epidemiology 32236476 Int J Epidemiol 2021 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/32236476
High-Dimensional Confounding Adjustment Using Continuous Spike and Slab Priors. Antonelli J, Parmigiani G, Dominici F Bayesian analysis 32431779 Bayesian Anal 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/32431779
Machine Learning for Prediction in Electronic Health Data. Rose S JAMA network open 30646089 JAMA Netw Open 2018 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/30646089
Incidence, Persistence, and Steady-State Prevalence in Coding Intensity for Health Plan Payment. McGuire TG, Enache OM, Chernew M, McWilliams JM, Nham T, Rose S medRxiv : the preprint server for health sciences 40321285 medRxiv 2025 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/40321285
Limitations of P-Values and R-squared for Stepwise Regression Building: A Fairness Demonstration in Health Policy Risk Adjustment. Rose S, McGuire TG The American statistician 31263291 Am Stat 2019 https://www.ncbi.nlm.nih.gov/pubmed/31263291
Discovering Heterogeneous Exposure Effects Using Randomization Inference in Air Pollution Studies. Lee K, Small DS, Dominici F Journal of the American Statistical Association 36311902 J Am Stat Assoc 2021 https://www.ncbi.nlm.nih.gov/pubmed/36311902
All Models are Wrong, but Many are Useful: Learning a Variable's Importance by Studying an Entire Class of Prediction Models Simultaneously. Fisher A, Rudin C, Dominici F Journal of machine learning research : JMLR 34335110 J Mach Learn Res 2019 https://www.ncbi.nlm.nih.gov/pubmed/34335110
A causal inference framework for cancer cluster investigations using publicly available data. Nethery RC, Yang Y, Brown AJ, Dominici F Journal of the Royal Statistical Society. Series A, (Statistics in Society) 34262243 J R Stat Soc Ser A Stat Soc 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/34262243
Considerations Across Three Cultures: Parametric Regressions, Interpretable Algorithms, and Complex Algorithms. Eloyan A, Rose S Observational studies.. 34485997 Obs Stud 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34485997
Identifying undercompensated groups defined by multiple attributes in risk adjustment. Zink A, Rose S BMJ health & care informatics 34535447 BMJ Health Care Inform 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34535447
Discussion on "Approval policies for modifications to machine learning-based software as a medical device: A study of biocreep" by Jean Feng, Scott Emerson, and Noah Simon. Rose S Biometrics 33040334 Biometrics 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33040334
Evaluation of the health impacts of the 1990 Clean Air Act Amendments using causal inference and machine learning. Nethery RC, Mealli F, Sacks JD, Dominici F Journal of the American Statistical Association 33424062 J Am Stat Assoc 2020 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/33424062
Evaluating Federal Policies Using Bayesian Time Series Models: Estimating the Causal Impact of the Hospital Readmissions Reduction Program. Papadogeorgou G, Menchetti F, Choirat C, Wasfy JH, Zigler CM, Mealli F Health services & outcomes research methodology 39866244 Health Serv Outcomes Res Methodol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/39866244
Food Insecurity and Health Care Expenditures in the United States, 2011-2013. Berkowitz SA, Basu S, Meigs JB, Seligman HK Health services research 28608473 Health Serv Res 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/28608473
Characteristics Associated With Decreased or Increased Mortality Risk From Glycemic Therapy Among Patients With Type 2 Diabetes and High Cardiovascular Risk: Machine Learning Analysis of the ACCORD Trial. Basu S, Raghavan S, Wexler DJ, Berkowitz SA Diabetes care 29279299 Diabetes Care 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29279299
Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial. Baum A, Scarpa J, Bruzelius E, Tamler R, Basu S, Faghmous J The lancet. Diabetes & endocrinology 28711469 Lancet Diabetes Endocrinol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28711469
Preventing false discovery of heterogeneous treatment effect subgroups in randomized trials. Rigdon J, Baiocchi M, Basu S Trials 30012181 Trials 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30012181
Mother's education and late-life disparities in memory and dementia risk among US military veterans and non-veterans. Vable AM, Eng CW, Mayeda ER, Basu S, Marden JR, Hamad R, Glymour MM Journal of epidemiology and community health 30082424 J Epidemiol Community Health 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30082424
Black-White Cardiovascular Disease Disparities After Target-Based Versus Personalized Benefit-Based Lipid and Blood Pressure Treatment. Basu S, Sussman JB, Hayward RA MDM policy & practice 30288429 MDM Policy Pract 2017 Jul-Dec https://www.ncbi.nlm.nih.gov/pubmed/30288429
Moderation of the Relation of County-Level Cost of Living to Nutrition by the Supplemental Nutrition Assistance Program. Basu S, Wimer C, Seligman H American journal of public health 27631742 Am J Public Health 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27631742
Comparative effectiveness and cost-effectiveness of treat-to-target versus benefit-based tailored treatment of type 2 diabetes in low-income and middle-income countries: a modelling analysis. Basu S, Shankar V, Yudkin JS The lancet. Diabetes & endocrinology 27717768 Lancet Diabetes Endocrinol 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27717768
Detecting Heterogeneous Treatment Effects to Guide Personalized Blood Pressure Treatment: A Modeling Study of Randomized Clinical Trials. Basu S, Sussman JB, Hayward RA Annals of internal medicine 28055048 Ann Intern Med 2017 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/28055048
BOUNDS ON THE CONDITIONAL AND AVERAGE TREATMENT EFFECT WITH UNOBSERVED CONFOUNDING FACTORS. Yadlowsky S, Namkoong H, Basu S, Duchi J, Tian L Annals of statistics 38050638 Ann Stat 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/38050638
A New Tool for Case Studies in Epidemiology-the Synthetic Control Method. Rehkopf DH, Basu S Epidemiology (Cambridge, Mass.) 29613871 Epidemiology 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29613871
Machine Learning Methods for Precision Medicine Research Designed to Reduce Health Disparities: A Structured Tutorial. Basu S, Faghmous JH, Doupe P Ethnicity & disease 32269464 Ethn Dis 2020 https://www.ncbi.nlm.nih.gov/pubmed/32269464
Assessment of Changes in the Geographical Distribution of Opioid-Related Mortality Across the United States by Opioid Type, 1999-2016. Kiang MV, Basu S, Chen J, Alexander MJ JAMA network open 30794299 JAMA Netw Open 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30794299
Clinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk. Yadlowsky S, Hayward RA, Sussman JB, McClelland RL, Min YI, Basu S Annals of internal medicine 29868850 Ann Intern Med 2018 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/29868850
Generalizing Intensive Blood Pressure Treatment to Adults With Diabetes Mellitus. Berkowitz SA, Sussman JB, Jonas DE, Basu S Journal of the American College of Cardiology 30189998 J Am Coll Cardiol 2018 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/30189998
Supplemental Nutrition Assistance Program (SNAP) Participation and Health Care Expenditures Among Low-Income Adults. Berkowitz SA, Seligman HK, Rigdon J, Meigs JB, Basu S JAMA internal medicine 28973507 JAMA Intern Med 2017 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/28973507
Re-evaluating associations between the Supplemental Nutrition Assistance Program participation and body mass index in the context of unmeasured confounders. Rigdon J, Berkowitz SA, Seligman HK, Basu S Social science & medicine (1982) 28965002 Soc Sci Med 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28965002
Military Service, Childhood Socio-Economic Status, and Late-Life Lung Function: Korean War Era Military Service Associated with Smaller Disparities. Vable AM, Kiang MV, Basu S, Rudolph KE, Kawachi I, Subramanian SV, Glymour MM Military medicine 29509934 Mil Med 2018 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/29509934
Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil. Mabud TS, de Lourdes Delgado Alves M, Ko AI, Basu S, Walter KS, Cohen T, Mathema B, Colijn C, Lemos E, Croda J, Andrews JR PLoS medicine 30677013 PLoS Med 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30677013
Opioid prescribing patterns among medical providers in the United States, 2003-17: retrospective, observational study. Kiang MV, Humphreys K, Cullen MR, Basu S BMJ (Clinical research ed.) 31996352 BMJ 2020 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/31996352
Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS The lancet. Diabetes & endocrinology 28803840 Lancet Diabetes Endocrinol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28803840
The Monthly Cycle of Hypoglycemia: An Observational Claims-based Study of Emergency Room Visits, Hospital Admissions, and Costs in a Commercially Insured Population. Basu S, Berkowitz SA, Seligman H Medical care 28481762 Med Care 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28481762
Food insecurity, healthcare utilization, and high cost: a longitudinal cohort study. Berkowitz SA, Seligman HK, Meigs JB, Basu S The American journal of managed care 30222918 Am J Manag Care 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30222918
Cost Effectiveness of Subsidizing Fruit and Vegetable Purchases Through the Supplemental Nutrition Assistance Program. Choi SE, Seligman H, Basu S American journal of preventive medicine 28153648 Am J Prev Med 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28153648
Machine learning with sparse nutrition data to improve cardiovascular mortality risk prediction in the USA using nationally randomly sampled data. Rigdon J, Basu S BMJ open 31784446 BMJ Open 2019 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/31784446
Personalizing Second-Line Type 2 Diabetes Treatment Selection: Combining Network Meta-analysis, Individualized Risk, and Patient Preferences for Unified Decision Support. Choi SE, Berkowitz SA, Yudkin JS, Naci H, Basu S Medical decision making : an international journal of the Society for Medical Decision Making 30767632 Med Decis Making 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30767632
Evaluating the Health Impact of Large-Scale Public Policy Changes: Classical and Novel Approaches. Basu S, Meghani A, Siddiqi A Annual review of public health 28384086 Annu Rev Public Health 2017 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/28384086
Health and Economic Implications of National Treatment Coverage for Cardiovascular Disease in India: Cost-Effectiveness Analysis. Basu S, Bendavid E, Sood N Circulation. Cardiovascular quality and outcomes 26555122 Circ Cardiovasc Qual Outcomes 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26555122
Illustrating a "consequential" shift in the study of health inequalities: a decomposition of racial differences in the distribution of body mass. Siddiqi A, Shahidi FV, Hildebrand V, Hong A, Basu S Annals of epidemiology 29576050 Ann Epidemiol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29576050
Association between access to social service resources and cardiometabolic risk factors: a machine learning and multilevel modeling analysis. Berkowitz SA, Basu S, Venkataramani A, Reznor G, Fleegler EW, Atlas SJ BMJ open 30862634 BMJ Open 2019 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/30862634
Huntington's disease in the United States: Variation by demographic and socioeconomic factors. Bruzelius E, Scarpa J, Zhao Y, Basu S, Faghmous JH, Baum A Movement disorders : official journal of the Movement Disorder Society 30868663 Mov Disord 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30868663
Health Behaviors, Mental Health, and Health Care Utilization Among Single Mothers After Welfare Reforms in the 1990s. Basu S, Rehkopf DH, Siddiqi A, Glymour MM, Kawachi I American journal of epidemiology 26946395 Am J Epidemiol 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26946395
Long-term effects of neighbourhood deprivation on diabetes risk: quasi-experimental evidence from a refugee dispersal policy in Sweden. White JS, Hamad R, Li X, Basu S, Ohlsson H, Sundquist J, Sundquist K The lancet. Diabetes & endocrinology 27131930 Lancet Diabetes Endocrinol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27131930
Benefit and harm of intensive blood pressure treatment: Derivation and validation of risk models using data from the SPRINT and ACCORD trials. Basu S, Sussman JB, Rigdon J, Steimle L, Denton BT, Hayward RA PLoS medicine 29040268 PLoS Med 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29040268
Validation of Risk Equations for Complications of Type 2 Diabetes (RECODe) Using Individual Participant Data From Diverse Longitudinal Cohorts in the U.S. Basu S, Sussman JB, Berkowitz SA, Hayward RA, Bertoni AG, Correa A, Mwasongwe S, Yudkin JS Diabetes care 29269511 Diabetes Care 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29269511
Matching Microsimulation Risk Factor Correlations to Cross-sectional Data: The Shortest Distance Method. Suen SC, Goldhaber-Fiebert JD, Basu S Medical decision making : an international journal of the Society for Medical Decision Making 29185378 Med Decis Making 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29185378
Impact of the North American Free Trade Agreement on high-fructose corn syrup supply in Canada: a natural experiment using synthetic control methods. Barlow P, McKee M, Basu S, Stuckler D CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 28676578 CMAJ 2017 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/28676578
Machine Learning for Health Services Researchers. Doupe P, Faghmous J, Basu S Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 31277828 Value Health 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31277828
Association of Primary Care Physician Supply With Population Mortality in the United States, 2005-2015. Basu S, Berkowitz SA, Phillips RL, Bitton A, Landon BE, Phillips RS JAMA internal medicine 30776056 JAMA Intern Med 2019 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/30776056
Estimating the long-run relationship between state cigarette taxes and county life expectancy. Baum A, Aguilar-Gomez S, Lightwood J, Bruzelius E, Glantz SA, Basu S Tobacco control 30705247 Tob Control 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/30705247
Detecting Anomalies Among Practice Sites Within Multicenter Trials. Berkowitz SA, Rudolph KE, Basu S Circulation. Cardiovascular quality and outcomes 30857413 Circ Cardiovasc Qual Outcomes 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30857413
Personalizing Medical Treatment Decisions: Integrating Meta-analytic Treatment Comparisons with Patient-Specific Risks and Preferences. Weyant C, Brandeau ML, Basu S Medical decision making : an international journal of the Society for Medical Decision Making 31707910 Med Decis Making 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31707910
Alternative Strategies to Achieve Cardiovascular Mortality Goals in China and India: A Microsimulation of Target- Versus Risk-Based Blood Pressure Treatment. Basu S, Yudkin JS, Sussman JB, Millett C, Hayward RA Circulation 26762520 Circulation 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26762520
Anticipated burden and mitigation of carbon-dioxide-induced nutritional deficiencies and related diseases: A simulation modeling study. Weyant C, Brandeau ML, Burke M, Lobell DB, Bendavid E, Basu S PLoS medicine 29969442 PLoS Med 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29969442
Dynamic treatment selection and modification for personalised blood pressure therapy using a Markov decision process model: a cost-effectiveness analysis. Choi SE, Brandeau ML, Basu S BMJ open 29146652 BMJ Open 2017 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/29146652
Performance of Matching Methods as Compared With Unmatched Ordinary Least Squares Regression Under Constant Effects. Vable AM, Kiang MV, Glymour MM, Rigdon J, Drabo EF, Basu S American journal of epidemiology 30995301 Am J Epidemiol 2019 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/30995301
Near-Far Matching in R: The nearfar Package. Rigdon J, Baiocchi M, Basu S Journal of statistical software 30386186 J Stat Softw 2018 https://www.ncbi.nlm.nih.gov/pubmed/30386186
Decomposition of the US black/white inequality in premature mortality, 2010-2015: an observational study. Kiang MV, Krieger N, Buckee CO, Onnela JP, Chen JT BMJ open 31748287 BMJ Open 2019 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/31748287
Basu et al. Respond to "Interdisciplinary Approach for Policy Evaluation". Basu S, Rehkopf DH, Siddiqi A, Glymour MM, Kawachi I American journal of epidemiology 26946397 Am J Epidemiol 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26946397
Are There Spillover Effects from the GI Bill? The Mental Health of Wives of Korean War Veterans. Vable AM, Kawachi I, Canning D, Glymour MM, Jimenez MP, Subramanian SV PloS one 27186983 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27186983
Gradient Descent Provably Solves Nonlinear Tomographic Reconstruction. Fridovich-Keil S, Valdivia F, Wetzstein G, Recht B, Soltanolkotabi M ArXiv 37873016 ArXiv 2023 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/37873016
Adapt and Diffuse: Sample-Adaptive Reconstruction Via Latent Diffusion Models. Fabian Z, Tinaz B, Soltanolkotabi M Proceedings of machine learning research 39318400 Proc Mach Learn Res 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/39318400
DiracDiffusion: Denoising and Incremental Reconstruction with Assured Data-Consistency. Fabian Z, Tinaz B, Soltanolkotabi M Proceedings of machine learning research 39416230 Proc Mach Learn Res 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/39416230
Provable Multi-Task Representation Learning by Two-Layer ReLU Neural Networks. Collins L, Hassani H, Soltanolkotabi M, Mokhtari A, Shakkottai S Proceedings of machine learning research 39421278 Proc Mach Learn Res 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/39421278
Towards aSmart Bionic Eye: AI-powered artificial vision for the treatment of incurable blindness. Beyeler M, Sanchez-Garcia M Journal of neural engineering 36541463 J Neural Eng 2022 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/36541463
Human-in-the-Loop Optimization for Deep Stimulus Encoding in Visual Prostheses. Granley J, Fauvel T, Chalk M, Beyeler M Advances in neural information processing systems 38984104 Adv Neural Inf Process Syst 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/38984104
Aligning Visual Prosthetic Development With Implantee Needs. Nadolskis L, Turkstra LM, Larnyo E, Beyeler M Translational vision science & technology 39570616 Transl Vis Sci Technol 2024 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/39570616
The Relative Importance of Depth Cues and Semantic Edges for Indoor Mobility Using Simulated Prosthetic Vision in Immersive Virtual Reality. Rasla A, Beyeler M Proceedings of the ACM Symposium on Virtual Reality Software and Technology. ACM Symposium on Virtual Reality Software and Technology 40017497 Proc ACM Symp Virtual Real Softw Technol 2022 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/40017497
Efficient Spatial Estimation of Perceptual Thresholds for Retinal Implants via Gaussian Process Regression. Sadeghi R, Beyeler M ArXiv 39990794 ArXiv 2025 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/39990794
A systematic review of extended reality (XR) for understanding and augmenting vision loss. Kasowski J, Johnson BA, Neydavood R, Akkaraju A, Beyeler M Journal of vision 37140911 J Vis 2023 May 2 https://www.ncbi.nlm.nih.gov/pubmed/37140911
Aligning visual prosthetic development with implantee needs. Nadolskis LG, Turkstra LM, Larnyo E, Beyeler M medRxiv : the preprint server for health sciences 38559196 medRxiv 2024 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/38559196
Performance Guarantees for Policy Learning. Luedtke A, Chambaz A Annales de l'I.H.P. Probabilites et statistiques 35321441 Ann I H P Probab Stat 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/35321441
Discussion of and : New Objectives for Policy Learning. Li S, Li X, Luedtke A Journal of the American Statistical Association 36910906 J Am Stat Assoc 2021 https://www.ncbi.nlm.nih.gov/pubmed/36910906
Adversarial Monte Carlo Meta-Learning of Optimal Prediction Procedures. Luedtke A, Chung I, Sofrygin O Journal of machine learning research : JMLR 38476310 J Mach Learn Res 2021 https://www.ncbi.nlm.nih.gov/pubmed/38476310
Inference for treatment-specific survival curves using machine learning. Westling T, Luedtke A, Gilbert PB, Carone M Journal of the American Statistical Association 39184837 J Am Stat Assoc 2024 https://www.ncbi.nlm.nih.gov/pubmed/39184837
Rejoinder: Optimal individualized decision rules using instrumental variable methods. Qiu H, Carone M, Sadikova E, Petukhova M, Kessler RC, Luedtke A Journal of the American Statistical Association 36092993 J Am Stat Assoc 2021 https://www.ncbi.nlm.nih.gov/pubmed/36092993
Correction to: "Optimal Individualized Decision Rules Using Instrumental Variable Methods". Qiu H, Carone M, Sadikova E, Petukhova M, Kessler RC, Luedtke A Journal of the American Statistical Association 35756162 J Am Stat Assoc 2021 https://www.ncbi.nlm.nih.gov/pubmed/35756162
Rejoinder: Improving precision and power in randomized trials for COVID-19 treatments using covariate adjustment, for binary, ordinal, and time-to-event outcomes. Benkeser D, Díaz I, Luedtke A, Segal J, Scharfstein D, Rosenblum M Biometrics 34050931 Biometrics 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34050931
Improving precision and power in randomized trials for COVID-19 treatments using covariate adjustment, for binary, ordinal, and time-to-event outcomes. Benkeser D, Díaz I, Luedtke A, Segal J, Scharfstein D, Rosenblum M Biometrics 32978962 Biometrics 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/32978962
Causal isotonic calibration for heterogeneous treatment effects. van der Laan L, Ulloa-Pérez E, Carone M, Luedtke A Proceedings of machine learning research 37575467 Proc Mach Learn Res 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37575467
EFFICIENT ESTIMATION OF THE MAXIMAL ASSOCIATION BETWEEN MULTIPLE PREDICTORS AND A SURVIVAL OUTCOME. Huang TJ, Luedtke A, McKeague IW Annals of statistics 38405375 Ann Stat 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/38405375
Improving Precision and Power in Randomized Trials for COVID-19 Treatments Using Covariate Adjustment, for Binary, Ordinal, and Time-to-Event Outcomes. Benkeser D, Díaz I, Luedtke A, Segal J, Scharfstein D, Rosenblum M medRxiv : the preprint server for health sciences 32577668 medRxiv 2020 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/32577668
Improved inference for vaccine-induced immune responses via shape-constrained methods. Laha N, Moodie Z, Huang Y, Luedtke A Electronic journal of statistics 37974631 Electron J Stat 2022 https://www.ncbi.nlm.nih.gov/pubmed/37974631
Re. Selecting Optimal Subgroups for Treatment Using Many Covariates. Penning de Vries BBL, Groenwold RHH, Luedtke A Epidemiology (Cambridge, Mass.) 32282408 Epidemiology 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32282408
Improved efficiency for cross-arm comparisons via platform designs. Huang TJ, Luedtke A, AMP INVESTIGATOR GROUP Biostatistics (Oxford, England) 35939566 Biostatistics 2023 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/35939566
Universal sieve-based strategies for efficient estimation using machine learning tools. Qiu H, Luedtke A, Carone M Bernoulli : official journal of the Bernoulli Society for Mathematical Statistics and Probability 34733110 Bernoulli (Andover) 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34733110
Discussion on "Estimating vaccine efficacy over time after a randomized study is unblinded" by Anastasios A. Tsiatis and Marie Davidian. Janes H, Gao F, Luedtke A Biometrics 34492117 Biometrics 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/34492117
Optimal individualized decision rules using instrumental variable methods. Qiu H, Carone M, Sadikova E, Petukhova M, Kessler RC, Luedtke A Journal of the American Statistical Association 33731969 J Am Stat Assoc 2021 https://www.ncbi.nlm.nih.gov/pubmed/33731969
Adversarial meta-learning of Gamma-minimax estimators that leverage prior knowledge. Qiu H, Luedtke A Electronic journal of statistics 38463692 Electron J Stat 2023 https://www.ncbi.nlm.nih.gov/pubmed/38463692
Estimating the Efficiency Gain of Covariate-Adjusted Analyses in Future Clinical Trials Using External Data. Li X, Li S, Luedtke A Journal of the Royal Statistical Society. Series B, Statistical methodology 37593690 J R Stat Soc Series B Stat Methodol 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/37593690
Efficient Estimation under Data Fusion. Li S, Luedtke A Biometrika 37982010 Biometrika 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37982010
A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease. Huang AT, Garcia-Carreras B, Hitchings MDT, Yang B, Katzelnick LC, Rattigan SM, Borgert BA, Moreno CA, Solomon BD, Rodriguez-Barraquer I, Lessler J, Salje H, Burke D, Wesolowski A, Cummings DAT medRxiv : the preprint server for health sciences 32511434 medRxiv 2020 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/32511434
Reconstructing unseen transmission events to infer dengue dynamics from viral sequences. Salje H, Wesolowski A, Brown TS, Kiang MV, Berry IM, Lefrancq N, Fernandez S, Jarman RG, Ruchusatsawat K, Iamsirithaworn S, Vandepitte WP, Suntarattiwong P, Read JM, Klungthong C, Thaisomboonsuk B, Engø-Monsen K, Buckee C, Cauchemez S, Cummings DAT Nature communications 33753725 Nat Commun 2021 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/33753725
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity. Huang AT, Garcia-Carreras B, Hitchings MDT, Yang B, Katzelnick LC, Rattigan SM, Borgert BA, Moreno CA, Solomon BD, Trimmer-Smith L, Etienne V, Rodriguez-Barraquer I, Lessler J, Salje H, Burke DS, Wesolowski A, Cummings DAT Nature communications 32943637 Nat Commun 2020 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/32943637
SARS-CoV-2 Testing in Florida, Illinois, and Maryland: Access and Barriers. Clipman SJ, Wesolowski A, Mehta SH, Agarwal S, Cobey SE, Cummings DAT, Gibson DG, Labrique AB, Kirk GD, Solomon SS medRxiv : the preprint server for health sciences 33398298 medRxiv 2020 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/33398298
Using geospatial models to map zero-dose children: factors associated with zero-dose vaccination status before and after a mass measles and rubella vaccination campaign in Southern province, Zambia. Arambepola R, Yang Y, Hutchinson K, Mwansa FD, Doherty JA, Bwalya F, Ndubani P, Musukwa G, Moss WJ, Wesolowski A, Mutembo S BMJ global health 34969682 BMJ Glob Health 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34969682
Existing human mobility data sources poorly predicted the spatial spread of SARS-CoV-2 in Madagascar. Ramiadantsoa T, Metcalf CJE, Raherinandrasana AH, Randrianarisoa S, Rice BL, Wesolowski A, Randriatsarafara FM, Rasambainarivo F Epidemics 34915300 Epidemics 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34915300
Infectious disease in an era of global change. Baker RE, Mahmud AS, Miller IF, Rajeev M, Rasambainarivo F, Rice BL, Takahashi S, Tatem AJ, Wagner CE, Wang LF, Wesolowski A, Metcalf CJE Nature reviews. Microbiology 34646006 Nat Rev Microbiol 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/34646006
High Plasmodium falciparum genetic diversity and temporal stability despite control efforts in high transmission settings along the international border between Zambia and the Democratic Republic of the Congo. Pringle JC, Wesolowski A, Berube S, Kobayashi T, Gebhardt ME, Mulenga M, Chaponda M, Bobanga T, Juliano JJ, Meshnick S, Moss WJ, Carpi G, Norris DE Malaria journal 31801548 Malar J 2019 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/31801548
Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa. Tessema S, Wesolowski A, Chen A, Murphy M, Wilheim J, Mupiri AR, Ruktanonchai NW, Alegana VA, Tatem AJ, Tambo M, Didier B, Cohen JM, Bennett A, Sturrock HJ, Gosling R, Hsiang MS, Smith DL, Mumbengegwi DR, Smith JL, Greenhouse B eLife 30938286 Elife 2019 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/30938286
Mapping imported malaria in Bangladesh using parasite genetic and human mobility data. Chang HH, Wesolowski A, Sinha I, Jacob CG, Mahmud A, Uddin D, Zaman SI, Hossain MA, Faiz MA, Ghose A, Sayeed AA, Rahman MR, Islam A, Karim MJ, Rezwan MK, Shamsuzzaman AKM, Jhora ST, Aktaruzzaman MM, Drury E, Gonçalves S, Kekre M, Dhorda M, Vongpromek R, Miotto O, Engø-Monsen K, Kwiatkowski D, Maude RJ, Buckee C eLife 30938289 Elife 2019 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/30938289
Seasonal gaps in measles vaccination coverage in Madagascar. Mensah K, Heraud JM, Takahashi S, Winter AK, Metcalf CJE, Wesolowski A Vaccine 30940486 Vaccine 2019 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/30940486
Mapping the travel patterns of people with malaria in Bangladesh. Sinha I, Sayeed AA, Uddin D, Wesolowski A, Zaman SI, Faiz MA, Ghose A, Rahman MR, Islam A, Karim MJ, Saha A, Rezwan MK, Shamsuzzaman AKM, Jhora ST, Aktaruzzaman MM, Chang HH, Miotto O, Kwiatkowski D, Dondorp AM, Day NPJ, Hossain MA, Buckee C, Maude RJ BMC medicine 32127002 BMC Med 2020 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/32127002
Aggregated mobility data could help fight COVID-19. Buckee CO, Balsari S, Chan J, Crosas M, Dominici F, Gasser U, Grad YH, Grenfell B, Halloran ME, Kraemer MUG, Lipsitch M, Metcalf CJE, Meyers LA, Perkins TA, Santillana M, Scarpino SV, Viboud C, Wesolowski A, Schroeder A Science (New York, N.Y.) 32205458 Science 2020 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/32205458
Seroprevalence of pertussis in Madagascar and implications for vaccination. Razafimahatratra SL, Wesolowski A, Rafetrarivony L, Heraud JM, Jones FK, Cauchemez S, Razafindratsimandresy R, Raharinantoanina SJ, Harimanana A, Collard JM, Metcalf CJE Epidemiology and infection 33190665 Epidemiol Infect 2020 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/33190665
Long-term dynamics of measles in London: Titrating the impact of wars, the 1918 pandemic, and vaccination. Becker AD, Wesolowski A, Bjørnstad ON, Grenfell BT PLoS computational biology 31513578 PLoS Comput Biol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31513578
Characterizing mobility patterns and malaria risk factors in semi-nomadic populations of Northern Kenya. Meredith HR, Wesolowski A, Okoth D, Maraga L, Ambani G, Chepkwony T, Abel L, Kipkoech J, Lokoel G, Esimit D, Lokemer S, Maragia J, Prudhomme O'Meara W, Obala AA PLOS global public health 38478562 PLOS Glob Public Health 2024 https://www.ncbi.nlm.nih.gov/pubmed/38478562
National-scale simulation of human movement in a spatially coupled individual-based model of malaria in Burkina Faso. Zupko RJ, Nguyen TD, Wesolowski A, Gerardin J, Boni MF Scientific reports 36609584 Sci Rep 2023 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/36609584
Long-term effects of increased adoption of artemisinin combination therapies in Burkina Faso. Zupko RJ, Nguyen TD, Somé AF, Tran TN, Gerardin J, Dudas P, Giang DDH, Tran KT, Wesolowski A, Ouédraogo JB, Boni MF PLOS global public health 36962300 PLOS Glob Public Health 2022 https://www.ncbi.nlm.nih.gov/pubmed/36962300
Characterizing mobility patterns and malaria risk factors in semi-nomadic populations of Northern Kenya. Meredith HR, Wesolowski A, Okoth D, Maraga L, Ambani G, Chepkwony T, Abel L, Kipkoech J, Lokoel G, Esimit D, Lokemer S, Maragia J, O'Meara WP, Obala AA medRxiv : the preprint server for health sciences 38106223 medRxiv 2023 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/38106223
Who is missed in a community-based survey: Assessment and implications of biases due to incomplete sampling frame in a community-based serosurvey, Choma and Ndola Districts, Zambia, 2022. Kostandova N, Mutembo S, Prosperi C, Mwansa FD, Nakazwe C, Namukoko H, Nachinga B, Chongwe G, Chilumba I, Matakala KH, Musukwa G, Hamahuwa M, Mufwambi W, Matoba J, Situtu K, Mutale I, Kong AC, Simulundu E, Ndubani P, Hasan AZ, Truelove SA, Winter AK, Carcelen AC, Lau B, Moss WJ, Wesolowski A PLOS global public health 38683820 PLOS Glob Public Health 2024 https://www.ncbi.nlm.nih.gov/pubmed/38683820
Geography versus sociodemographics as predictors of changes in daily mobility across the USA during the COVID-19 pandemic: a two-stage regression analysis across 26 metropolitan areas. Schaber K, Arambepola R, Schluth C, Labrique AB, Mehta SH, Solomon SS, Cummings DAT, Wesolowski A BMJ open 38986558 BMJ Open 2024 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/38986558
Fine scale human mobility changes within 26 US cities in 2020 in response to the COVID-19 pandemic were associated with distance and income. Arambepola R, Schaber KL, Schluth C, Huang AT, Labrique AB, Mehta SH, Solomon SS, Cummings DAT, Wesolowski A PLOS global public health 37478056 PLOS Glob Public Health 2023 https://www.ncbi.nlm.nih.gov/pubmed/37478056
Coexisting attractors in the context of cross-scale population dynamics: measles in London as a case study. Becker AD, Zhou SH, Wesolowski A, Grenfell BT Proceedings. Biological sciences 32315586 Proc Biol Sci 2020 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/32315586
Genetic Evidence of Focal Plasmodium falciparum Transmission in a Pre-elimination Setting in Southern Province, Zambia. Pringle JC, Tessema S, Wesolowski A, Chen A, Murphy M, Carpi G, Shields TM, Hamapumbu H, Searle KM, Kobayashi T, Katowa B, Musonda M, Stevenson JC, Thuma PE, Greenhouse B, Moss WJ, Norris DE The Journal of infectious diseases 30445612 J Infect Dis 2019 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/30445612
A Mixture Model for Estimating SARS-CoV-2 Seroprevalence in Chennai, India. Hitchings MDT, Patel EU, Khan R, Srikrishnan AK, Anderson M, Kumar KS, Wesolowski AP, Iqbal SH, Rodgers MA, Mehta SH, Cloherty G, Cummings DAT, Solomon SS American journal of epidemiology 37084085 Am J Epidemiol 2023 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/37084085
Impact of disruptions to routine vaccination programs, quantifying burden of measles, and mapping targeted supplementary immunization activities. Kostandova N, Loisate S, Winter A, Moss WJ, Giles JR, Metcalf CJE, Mutembo S, Wesolowski A Epidemics 36343498 Epidemics 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36343498
Holiday gatherings, mobility and SARS-CoV-2 transmission: results from 10 US states following Thanksgiving. Mehta SH, Clipman SJ, Wesolowski A, Solomon SS Scientific reports 34462499 Sci Rep 2021 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/34462499
Existing human mobility data sources poorly predicted the spatial spread of SARS-CoV-2 in Madagascar. Ramiadantsoa T, Metcalf CJE, Raherinandrasana AH, Randrianarisoa S, Rice BL, Wesolowski A, Randriatsarafara FM, Rasambainarivo F medRxiv : the preprint server for health sciences 34373863 medRxiv 2021 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/34373863
Trip duration drives shift in travel network structure with implications for the predictability of spatial disease spread. Giles JR, Cummings DAT, Grenfell BT, Tatem AJ, Erbach-Schoenberg EZ, Metcalf C, Wesolowski A PLoS computational biology 34375331 PLoS Comput Biol 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34375331
The Challenge of Achieving Immunity Through Multiple-Dose Vaccines in Madagascar. Jones FK, Mensah K, Heraud JM, Randriatsarafara FM, Metcalf CJE, Wesolowski A American journal of epidemiology 34023892 Am J Epidemiol 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34023892
The duration of travel impacts the spatial dynamics of infectious diseases. Giles JR, Zu Erbach-Schoenberg E, Tatem AJ, Gardner L, Bjørnstad ON, Metcalf CJE, Wesolowski A Proceedings of the National Academy of Sciences of the United States of America 32839329 Proc Natl Acad Sci U S A 2020 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/32839329
Using models to shape measles control and elimination strategies in low- and middle-income countries: A review of recent applications. Cutts FT, Dansereau E, Ferrari MJ, Hanson M, McCarthy KA, Metcalf CJE, Takahashi S, Tatem AJ, Thakkar N, Truelove S, Utazi E, Wesolowski A, Winter AK Vaccine 31787412 Vaccine 2020 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/31787412
Exploring how space, time, and sampling impact our ability to measure genetic structure across Plasmodium falciparum populations. Arambepola R, Bérubé S, Freedman B, Taylor SM, Prudhomme O'Meara W, Obala AA, Wesolowski A Frontiers in epidemiology 38516334 Front Epidemiol 2023 https://www.ncbi.nlm.nih.gov/pubmed/38516334
A systematic review of using population-level human mobility data to understand SARS-CoV-2 transmission. Kostandova N, Schluth C, Arambepola R, Atuhaire F, Bérubé S, Chin T, Cleary E, Cortes-Azuero O, García-Carreras B, Grantz KH, Hitchings MDT, Huang AT, Kishore N, Lai S, Larsen SL, Loisate S, Martinez P, Meredith HR, Purbey R, Ramiadantsoa T, Read J, Rice BL, Rosman L, Ruktanonchai N, Salje H, Schaber KL, Tatem AJ, Wang J, Cummings DAT, Wesolowski A Nature communications 39627231 Nat Commun 2024 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/39627231
Towards better targeting: lessons from a posthoneymoon measles outbreak in Madagascar, 2018-2019. Raherindrasana A, Metcalf CJ, Heraud JM, Cauchemez S, Winter A, Wesolowski A, Razafindratsimandresy R, Randriamampionona L, Rafalimanantsoa SA, Masembe Y, Ndiaye C, Rakotonirina J BMJ global health 33082133 BMJ Glob Health 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33082133
Effect of non-pharmaceutical interventions to contain COVID-19 in China. Lai S, Ruktanonchai NW, Zhou L, Prosper O, Luo W, Floyd JR, Wesolowski A, Santillana M, Zhang C, Du X, Yu H, Tatem AJ Nature 32365354 Nature 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32365354
Development and dissemination of infectious disease dynamic transmission models during the COVID-19 pandemic: what can we learn from other pathogens and how can we move forward? Becker AD, Grantz KH, Hegde ST, Bérubé S, Cummings DAT, Wesolowski A The Lancet. Digital health 33735068 Lancet Digit Health 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33735068
Challenges in evaluating risks and policy options around endemic establishment or elimination of novel pathogens. Metcalf CJE, Andriamandimby SF, Baker RE, Glennon EE, Hampson K, Hollingsworth TD, Klepac P, Wesolowski A Epidemics 34823222 Epidemics 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34823222
Rapid real-time tracking of non-pharmaceutical interventions and their association with SARS-CoV-2 positivity: The COVID-19 Pandemic Pulse Study. Clipman SJ, Wesolowski AP, Gibson DG, Agarwal S, Lambrou AS, Kirk GD, Labrique AB, Mehta SH, Solomon SS medRxiv : the preprint server for health sciences 32766598 medRxiv 2020 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/32766598
Rapid Real-time Tracking of Nonpharmaceutical Interventions and Their Association With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity: The Coronavirus Disease 2019 (COVID-19) Pandemic Pulse Study. Clipman SJ, Wesolowski AP, Gibson DG, Agarwal S, Lambrou AS, Kirk GD, Labrique AB, Mehta SH, Solomon SS Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 32877921 Clin Infect Dis 2021 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/32877921
The use of mobile phone data to inform analysis of COVID-19 pandemic epidemiology. Grantz KH, Meredith HR, Cummings DAT, Metcalf CJE, Grenfell BT, Giles JR, Mehta S, Solomon S, Labrique A, Kishore N, Buckee CO, Wesolowski A Nature communications 32999287 Nat Commun 2020 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/32999287
Prioritizing COVID-19 vaccination efforts and dose allocation within Madagascar. Rasambainarivo F, Ramiadantsoa T, Raherinandrasana A, Randrianarisoa S, Rice BL, Evans MV, Roche B, Randriatsarafara FM, Wesolowski A, Metcalf JC BMC public health 35413894 BMC Public Health 2022 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/35413894
Epidemiology of Plasmodium falciparum Infections in a Semi-Arid Rural African Setting: Evidence from Reactive Case Detection in Northwestern Kenya. Meredith HR, Wesolowski A, Menya D, Esimit D, Lokoel G, Kipkoech J, Freedman B, Lokemer S, Maragia J, Ambani G, Taylor SM, Prudhomme-O'Meara W, Obala AA The American journal of tropical medicine and hygiene 34339387 Am J Trop Med Hyg 2021 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/34339387
Improvements in Severe Acute Respiratory Syndrome Coronavirus 2 Testing Cascade in the United States: Data From Serial Cross-sectional Assessments. Clipman SJ, Wesolowski A, Mehta SH, Cobey S, Cummings DAT, Solomon SS Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 34374758 Clin Infect Dis 2022 May 3 https://www.ncbi.nlm.nih.gov/pubmed/34374758
Characterizing human mobility patterns in rural settings of sub-Saharan Africa. Meredith HR, Giles JR, Perez-Saez J, Mande T, Rinaldo A, Mutembo S, Kabalo EN, Makungo K, Buckee CO, Tatem AJ, Metcalf CJE, Wesolowski A eLife 34533456 Elife 2021 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/34533456
Mapping malaria by combining parasite genomic and epidemiologic data. Wesolowski A, Taylor AR, Chang HH, Verity R, Tessema S, Bailey JA, Alex Perkins T, Neafsey DE, Greenhouse B, Buckee CO BMC medicine 30333020 BMC Med 2018 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/30333020
Changes in mobility patterns during the COVID-19 pandemic in Zambia: Implications for the effectiveness of NPIs in Sub-Saharan Africa. Loisate S, Mutembo S, Arambepola R, Makungo K, Kabalo EN, Sinyange NB, Kapata N, Liwewe M, Silumezi A, Chongwe G, Kostandova N, Truelove S, Wesolowski A PLOS global public health 37906535 PLOS Glob Public Health 2023 https://www.ncbi.nlm.nih.gov/pubmed/37906535
Adjusting mobile phone data to account for children's travel and the impact on measles dynamics in Zambia. Kostandova N, Prosperi C, Mutembo S, Nakazwe C, Namukoko H, Nachinga B, Chongwe G, Chilumba I, Kabalo EN, Makungo K, Matakala KH, Musukwa G, Hamahuwa M, Mufwambi W, Matoba J, Mutale I, Simulundu E, Ndubani P, Hasan AZ, Truelove SA, Winter AK, Carcelen AC, Lau B, Moss WJ, Wesolowski A American journal of epidemiology 39191642 Am J Epidemiol 2025 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/39191642
Clinician Testing and Treatment Thresholds for Management of Urinary Tract Infection. Harris A, Pineles L, Baghdadiv JD, Magder L, Dhaliwal G, Korenstein D, Harris AD, Morgan DJ Open forum infectious diseases 37720701 Open Forum Infect Dis 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37720701
Clinician Attitudes and Beliefs Associated with More Aggressive Diagnostic Testing. Korenstein D, Scherer LD, Foy A, Pineles L, Lydecker AD, Owczarzak J, Magder L, Brown JP, Pfeiffer CD, Terndrup C, Leykum L, Stevens D, Feldstein DA, Weisenberg SA, Baghdadi JD, Morgan DJ The American journal of medicine 35307357 Am J Med 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35307357
Medical overuse of therapies and diagnostics in rheumatology. Khawaja MN, Alhassan E, Bilal J, Jatwani S, Mehta B, Bhalla V, Morgan DJ, Siaton BC, Hochberg MC Clinical rheumatology 33569709 Clin Rheumatol 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33569709
Clinician Conceptualization of the Benefits of Treatments for Individual Patients. Morgan DJ, Pineles L, Owczarzak J, Magder L, Scherer L, Brown JP, Pfeiffer C, Terndrup C, Leykum L, Feldstein D, Foy A, Stevens D, Koch C, Masnick M, Weisenberg S, Korenstein D JAMA network open 34287630 JAMA Netw Open 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/34287630
Accuracy of Practitioner Estimates of Probability of Diagnosis Before and After Testing. Morgan DJ, Pineles L, Owczarzak J, Magder L, Scherer L, Brown JP, Pfeiffer C, Terndrup C, Leykum L, Feldstein D, Foy A, Stevens D, Koch C, Masnick M, Weisenberg S, Korenstein D JAMA internal medicine 33818595 JAMA Intern Med 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/33818595
Exploration of Primary Care Clinician Attitudes and Cognitive Characteristics Associated With Prescribing Antibiotics for Asymptomatic Bacteriuria. Baghdadi JD, Korenstein D, Pineles L, Scherer LD, Lydecker AD, Magder L, Stevens DN, Morgan DJ JAMA network open 35622364 JAMA Netw Open 2022 May 2 https://www.ncbi.nlm.nih.gov/pubmed/35622364
Reply to Fakih and Advani. Trautner BW, Morgan DJ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 33821997 Clin Infect Dis 2021 May 4 https://www.ncbi.nlm.nih.gov/pubmed/33821997
Game-based learning to improve diagnostic accuracy: a pilot randomized-controlled trial. Morgan DJ, Scherer L, Pineles L, Baghdadi J, Magder L, Thom K, Koch C, Wilkins N, LeGrand M, Stevens D, Walker R, Shirrell B, Harris AD, Korenstein D Diagnosis (Berlin, Germany) 38284830 Diagnosis (Berl) 2024 May 1 https://www.ncbi.nlm.nih.gov/pubmed/38284830
Efficacy of educational video game versus traditional educational apps at improving physician decision making in trauma triage: randomized controlled trial. Mohan D, Farris C, Fischhoff B, Rosengart MR, Angus DC, Yealy DM, Wallace DJ, Barnato AE BMJ (Clinical research ed.) 29233854 BMJ 2017 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/29233854
Selection bias, interventions and outcomes for survivors of cardiac arrest. Wallace DJ, Coppler P, Callaway C, Rittenberger JC, Dezfulian C, Mohan D, Toma C, Elmer J Heart (British Cardiac Society) 29463613 Heart 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29463613
Serious games may improve physician heuristics in trauma triage. Mohan D, Fischhoff B, Angus DC, Rosengart MR, Wallace DJ, Yealy DM, Farris C, Chang CH, Kerti S, Barnato AE Proceedings of the National Academy of Sciences of the United States of America 30150397 Proc Natl Acad Sci U S A 2018 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/30150397
Using Virtual Reality Simulation Environments to Assess Competence for Emergency Medicine Learners. McGrath JL, Taekman JM, Dev P, Danforth DR, Mohan D, Kman N, Crichlow A, Bond WF Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 28888070 Acad Emerg Med 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/28888070
Testing the feasibility, acceptability, and preliminary effect of a novel deliberate practice intervention to reduce diagnostic error in trauma triage: a study protocol for a randomized pilot trial. Mohan D, Elmer J, Arnold RM, Forsythe RM, Fischhoff B, Rak K, Barnes JL, White DB Pilot and feasibility studies 36510328 Pilot Feasibility Stud 2022 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/36510328
Not Thinking Clearly? Play a Game, Seriously! Mohan D, Schell J, Angus DC JAMA 27825014 JAMA 2016 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/27825014
Using incentives to recruit physicians into behavioral trials: lessons learned from four studies. Mohan D, Rosengart MR, Fischhoff B, Angus DC, Wallace DJ, Farris C, Yealy DM, Barnato AE BMC research notes 29282154 BMC Res Notes 2017 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/29282154
Referral Regions for Time-Sensitive Acute Care Conditions in the United States. Wallace DJ, Mohan D, Angus DC, Driessen JR, Seymour CM, Yealy DM, Roberts MM, Kurland KS, Kahn JM Annals of emergency medicine 29606286 Ann Emerg Med 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29606286
Using a theory-based, customized video game as an educational tool to improve physicians' trauma triage decisions: study protocol for a randomized cluster trial. Mohan D, Angus DC, Chang CH, Elmer J, Fischhoff B, Rak KJ, Barnes JL, Peitzman AB, White DB Trials 38365758 Trials 2024 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/38365758
Inner Deliberations of Surgeons Treating Critically-ill Emergency General Surgery Patients: A Qualitative Analysis. Kulkarni SS, Briggs A, Sacks OA, Rosengart MR, White DB, Barnato AE, Peitzman AB, Mohan D Annals of surgery 31714316 Ann Surg 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/31714316
Nudges in the Care of the Critically Ill. Wallace DJ, Drake C, Mohan D Critical care medicine 31305299 Crit Care Med 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31305299
Testing a videogame intervention to recalibrate physician heuristics in trauma triage: study protocol for a randomized controlled trial. Mohan D, Rosengart MR, Fischhoff B, Angus DC, Farris C, Yealy DM, Wallace DJ, Barnato AE BMC emergency medicine 27835981 BMC Emerg Med 2016 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/27835981
Testing a Novel Deliberate Practice Intervention to Improve Diagnostic Reasoning in Trauma Triage: A Pilot Randomized Clinical Trial. Mohan D, Elmer J, Arnold RM, Forsythe RM, Fischhoff B, Rak K, Barnes JL, White DB JAMA network open 37195666 JAMA Netw Open 2023 May 1 https://www.ncbi.nlm.nih.gov/pubmed/37195666
Defining the representativeness heuristic in trauma triage: A retrospective observational cohort study. Kulkarni SS, Dewitt B, Fischhoff B, Rosengart MR, Angus DC, Saul M, Yealy DM, Mohan D PloS one 30735553 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/30735553
Videogame intervention to increase advance care planning conversations by hospitalists with older adults: study protocol for a stepped-wedge clinical trial. Mohan D, O'Malley AJ, Chelen J, MacMartin M, Murphy M, Rudolph M, Barnato A BMJ open 33753443 BMJ Open 2021 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/33753443
Does Preexisting Practice Modify How Video Games Recalibrate Physician Heuristics in Trauma Triage? Kulkarni SS, Barnato AE, Rosengart MR, Fischhoff B, Angus DC, Yealy DM, Wallace DJ, Mohan D The Journal of surgical research 31071605 J Surg Res 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31071605
Development of a theory-based video-game intervention to increase advance care planning conversations by healthcare providers. Mohan D, MacMartin MA, Chelen JSC, Maezes CB, Barnato AE Implementation science communications 34645515 Implement Sci Commun 2021 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/34645515
Outcomes after a Digital Behavior Change Intervention to Improve Trauma Triage: An Analysis of Medicare Claims. Mohan D, Chang CC, Fischhoff B, Rosengart MR, Angus DC, Yealy DM, Barnato AE The Journal of surgical research 34464890 J Surg Res 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34464890
Association of Practitioner Interfacility Triage Performance With Outcomes for Severely Injured Patients With Fee-for-Service Medicare Insurance. Mohan D, Wallace DJ, Kerti SJ, Angus DC, Rosengart MR, Barnato AE, Yealy DM, Fischhoff B, Chang CC, Kahn JM JAMA surgery 31642889 JAMA Surg 2019 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/31642889
Constructing within and between hospital physician social networks for modeling physician research participation. Bobak CA, Mohan D, Murphy MA, Barnato AE, O'Malley AJ BMC medical research methodology 37898745 BMC Med Res Methodol 2023 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/37898745
Using a Video Game Intervention to Increase Hospitalists' Advance Care Planning Conversations with Older Adults: a Stepped Wedge Randomized Clinical Trial. Mohan D, O'Malley AJ, Chelen J, MacMartin M, Murphy M, Rudolph M, Engel JA, Barnato AE Journal of general internal medicine 37429972 J Gen Intern Med 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37429972
Influence of Stress and Antibiotic Resistance on Cell-Length Distribution in Mycobacterium tuberculosis Clinical Isolates. Vijay S, Vinh DN, Hai HT, Ha VTN, Dung VTM, Dinh TD, Nhung HN, Tram TTB, Aldridge BB, Hanh NT, Thu DDA, Phu NH, Thwaites GE, Thuong NTT Frontiers in microbiology 29209302 Front Microbiol 2017 https://www.ncbi.nlm.nih.gov/pubmed/29209302
Stress-Induced Reorganization of the Mycobacterial Membrane Domain. Hayashi JM, Richardson K, Melzer ES, Sandler SJ, Aldridge BB, Siegrist MS, Morita YS mBio 29362232 mBio 2018 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/29362232
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling. Li M, Patel HV, Cognetta AB 3rd, Smith TC 2nd, Mallick I, Cavalier JF, Previti ML, Canaan S, Aldridge BB, Cravatt BF, Seeliger JC Cell chemical biology 34599873 Cell Chem Biol 2022 May 19 https://www.ncbi.nlm.nih.gov/pubmed/34599873
Spatially distinct and metabolically active membrane domain in mycobacteria. Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS Proceedings of the National Academy of Sciences of the United States of America 27114527 Proc Natl Acad Sci U S A 2016 May 10 https://www.ncbi.nlm.nih.gov/pubmed/27114527
Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action. Boot M, Commandeur S, Subudhi AK, Bahira M, Smith TC 2nd, Abdallah AM, van Gemert M, Lelièvre J, Ballell L, Aldridge BB, Pain A, Speer A, Bitter W Antimicrobial agents and chemotherapy 29661879 Antimicrob Agents Chemother 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29661879
Temporal and intrinsic factors of rifampicin tolerance in mycobacteria. Richardson K, Bennion OT, Tan S, Hoang AN, Cokol M, Aldridge BB Proceedings of the National Academy of Sciences of the United States of America 27357669 Proc Natl Acad Sci U S A 2016 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/27357669
Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis. Ma S, Jaipalli S, Larkins-Ford J, Lohmiller J, Aldridge BB, Sherman DR, Chandrasekaran S mBio 31719182 mBio 2019 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/31719182
Morphological profiling of tubercle bacilli identifies drug pathways of action. Smith TC 2nd, Pullen KM, Olson MC, McNellis ME, Richardson I, Hu S, Larkins-Ford J, Wang X, Freundlich JS, Ando DM, Aldridge BB Proceedings of the National Academy of Sciences of the United States of America 32680963 Proc Natl Acad Sci U S A 2020 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/32680963
Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection. Sukumar N, Tan S, Aldridge BB, Russell DG PLoS pathogens 25233380 PLoS Pathog 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25233380
Stable Regulation of Cell Cycle Events in Mycobacteria: Insights From Inherently Heterogeneous Bacterial Populations. Logsdon MM, Aldridge BB Frontiers in microbiology 29619019 Front Microbiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29619019
Prediction of ultra-high-order antibiotic combinations based on pairwise interactions. Katzir I, Cokol M, Aldridge BB, Alon U PLoS computational biology 30699106 PLoS Comput Biol 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30699106
Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis. Cokol M, Kuru N, Bicak E, Larkins-Ford J, Aldridge BB Science advances 29026882 Sci Adv 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29026882
Rv0004 is a new essential member of the mycobacterial DNA replication machinery. Mann KM, Huang DL, Hooppaw AJ, Logsdon MM, Richardson K, Lee HJ, Kimmey JM, Aldridge BB, Stallings CL PLoS genetics 29176877 PLoS Genet 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/29176877
Localization of EccA(3) at the growing pole in Mycobacterium smegmatis. Kriel NL, Newton-Foot M, Bennion OT, Aldridge BB, Mehaffy C, Belisle JT, Walzl G, Warren RM, Sampson SL, Gey van Pittius NC BMC microbiology 35590245 BMC Microbiol 2022 May 19 https://www.ncbi.nlm.nih.gov/pubmed/35590245
A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization. Logsdon MM, Ho PY, Papavinasasundaram K, Richardson K, Cokol M, Sassetti CM, Amir A, Aldridge BB Current biology : CB 29107550 Curr Biol 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/29107550
Foundation models for generalizable electrocardiogram interpretation: comparison of supervised and self-supervised electrocardiogram foundation models. Nolin-Lapalme A, Sowa A, Delfrate J, Tastet O, Corbin D, Kulbay M, Ozdemir D, Noël MJ, Marois-Blanchet FC, Harvey F, Sharma S, Ansari M, Chiu IM, Dsouza V, Friedman SF, Chassé M, Potter BJ, Afilalo J, Elias PA, Jabbour G, Bahani M, Dubé MP, Boyle PM, Chatterjee NA, Barrios J, Tison GH, Ouyang D, Maddah M, Khurshid S, Cadrin-Tourigny J, Tadros R, Hussin J, Avram R medRxiv : the preprint server for health sciences 40093248 medRxiv 2025 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/40093248
Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues. Gorashi RM, Baddour T, Chittle SJ, Vélez NEF, Wenning MA, Anseth KS, Mestroni L, Peña B, Guo P, Aguado BA bioRxiv : the preprint server for biology 38798394 bioRxiv 2024 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/38798394
Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype. Felisbino MB, Rubino M, Travers JG, Schuetze KB, Lemieux ME, Anseth KS, Aguado BA, McKinsey TA American journal of physiology. Heart and circulatory physiology 37889253 Am J Physiol Heart Circ Physiol 2024 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/37889253
Secreted Cytokines From Inflammatory Macrophages Modulate Sex Differences in Valvular Interstitial Cells on Hydrogel Biomaterials. Félix Vélez NE, Tu K, Guo P, Reeves RR, Aguado BA Journal of biomedical materials research. Part A 39995146 J Biomed Mater Res A 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39995146
Y chromosome-linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues. Gorashi RM, Baddour T, Chittle SJ, Félix Vélez NE, Wenning MA, Anseth KS, Mestroni L, Peña B, Guo P, Aguado BA Science advances 40073144 Sci Adv 2025 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/40073144
Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration. Dhillon-Richardson RM, Haugan AK, Lyons LW, McKenna JK, Bronner ME, Martik ML bioRxiv : the preprint server for biology 39868190 bioRxiv 2025 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/39868190
Reactivation of an embryonic cardiac neural crest transcriptional profile during zebrafish heart regeneration. Dhillon-Richardson RM, Haugan AK, Lyons LW, McKenna JK, Bronner ME, Martik ML Proceedings of the National Academy of Sciences of the United States of America 40531881 Proc Natl Acad Sci U S A 2025 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/40531881
Daily social comparisons among women in midlife with elevated risk for cardiovascular disease: A within-person test of the identification/contrast model. Baga K, Salvatore GM, Bercovitz I, Mogle JA, Arigo D Applied psychology. Health and well-being 38785210 Appl Psychol Health Well Being 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/38785210
Digital, Social Micro-Interventions to Promote Physical Activity Among Midlife Adults With Elevated Cardiovascular Risk: An Ambulatory Feasibility Study With Momentary Randomization. Arigo D, Schumacher LM, Baga K, Mogle JA Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 39454044 Ann Behav Med 2024 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/39454044
A Low-Cost, Open-Source 3D Printer for Multimaterial and High-Throughput Direct Ink Writing of Soft and Living Materials. Weiss JD, Mermin-Bunnell A, Solberg FS, Tam T, Rosalia L, Sharir A, Rütsche D, Sinha S, Choi PS, Shibata M, Palagani Y, Nilkant R, Paulvannan K, Ma M, Skylar-Scott MA Advanced materials (Deerfield Beach, Fla.) 39748617 Adv Mater 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39748617
Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing. Sexton ZA, Hudson AR, Herrmann JE, Shiwarski DJ, Pham J, Szafron JM, Wu SM, Skylar-Scott M, Feinberg AW, Marsden A ArXiv 37645046 ArXiv 2023 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/37645046
A Visual, In-Expensive, and Wireless Capillary Rheometer for Characterizing Wholly-Cellular Bioinks. Du J, Lee S, Sinha S, Solberg FS, Ho DLL, Sampson JP, Wang Q, Tam T, Skylar-Scott MA Small (Weinheim an der Bergstrasse, Germany) 38085139 Small 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38085139
Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission. Zhang S, Grifno G, Passaro R, Regan K, Zheng S, Hadzipasic M, Banerji R, O'Connor L, Chu V, Kim SY, Yang J, Shi L, Karrobi K, Roblyer D, Grinstaff MW, Nia HT Nature biomedical engineering 37640900 Nat Biomed Eng 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37640900
The peritumor microenvironment: physics and immunity. Zhang S, Regan K, Najera J, Grinstaff MW, Datta M, Nia HT Trends in cancer 37156677 Trends Cancer 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37156677
Multiscale elasticity mapping of biological samples in 3D at optical resolution. Regan K, LeBourdais R, Banerji R, Zhang S, Muhvich J, Zheng S, Nia HT Acta biomaterialia 38160857 Acta Biomater 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/38160857
Crystal ribcage: a platform for probing real-time lung function at cellular resolution. Banerji R, Grifno GN, Shi L, Smolen D, LeBourdais R, Muhvich J, Eberman C, Hiller BE, Lee J, Regan K, Zheng S, Zhang S, Jiang J, Raslan AA, Breda JC, Pihl R, Traber K, Mazzilli S, Ligresti G, Mizgerd JP, Suki B, Nia HT Nature methods 37710017 Nat Methods 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37710017
B cells in the pneumococcus-infected lung are heterogeneous and require CD4(+) T cell help including CD40L to become resident memory B cells. Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP Frontiers in immunology 38715601 Front Immunol 2024 https://www.ncbi.nlm.nih.gov/pubmed/38715601
Emergence of nanoscale viscoelasticity from single cancer cells to established tumors. Hadzipasic M, Zhang S, Huang Z, Passaro R, Sten MS, Shankar GM, Nia HT Biomaterials 38169188 Biomaterials 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38169188
Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke. Zheng S, Banerji R, LeBourdais R, Zhang S, DuBois E, O'Shea T, Nia HT PNAS nexus 38659974 PNAS Nexus 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38659974
Mapping the strain-stiffening behavior of the lung and lung cancer at microscale resolution using the crystal ribcage. LeBourdais R, Grifno GN, Banerji R, Regan K, Suki B, Nia HT Frontiers in network physiology 39050550 Front Netw Physiol 2024 https://www.ncbi.nlm.nih.gov/pubmed/39050550
A CAR enhancer increases the activity and persistence of CAR T cells. Rakhshandehroo T, Mantri SR, Moravej H, Louis BBV, Salehi Farid A, Munaretto L, Regan K, Khan RMM, Wolff A, Farkash Z, Cong M, Kuhnast A, Nili A, Lee UJ, Allen HH, Berland L, Simkova E, Uslu SC, Tavakolpour S, Rowley JE, Codet E, Shahbazian H, Baral J, Pyrdol J, Jacobson CA, Nadeem O, Nia HT, Wucherpfennig KW, Rashidian M Nature biotechnology 39079964 Nat Biotechnol 2025 Jun https://www.ncbi.nlm.nih.gov/pubmed/39079964
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Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models. Baranwal T, Lebert J, Christoph J APL machine learning 39364376 APL Mach Learn 2024 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/39364376
The inhibition of cellular toxicity of amyloid-β by dissociated transthyretin. Cao Q, Anderson DH, Liang WY, Chou J, Saelices L The Journal of biological chemistry 32769117 J Biol Chem 2020 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/32769117
Conformational inhibitors of protein aggregation. Fernández Ramírez MDC, Afrin S, Saelices L Current opinion in structural biology 37717490 Curr Opin Struct Biol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37717490
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR Nature chemical biology 38347213 Nat Chem Biol 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38347213
Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients. Pedretti R, Wang L, Yakubovska A, Zhang QS, Nguyen B, Grodin JL, Masri A, Saelices L JACC. Basic to translational science 39444930 JACC Basic Transl Sci 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39444930
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS bioRxiv : the preprint server for biology 33688654 bioRxiv 2021 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/33688654
Disease-associated patterns of acetylation stabilize tau fibril formation. Li L, Nguyen B, Mullapudi V, Saelices L, Joachimiak LA bioRxiv : the preprint server for biology 36711822 bioRxiv 2023 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/36711822
Disease-associated patterns of acetylation stabilize tau fibril formation. Li L, Nguyen BA, Mullapudi V, Li Y, Saelices L, Joachimiak LA Structure (London, England : 1993) 37348495 Structure 2023 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/37348495
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis. Pedretti R, Wang L, Hanna M, Benson MD, Grodin JL, Tang WHW, Masri A, Saelices L Circulation 38768274 Circulation 2024 May 21 https://www.ncbi.nlm.nih.gov/pubmed/38768274
Biomarkers in Subclinical Transthyretin Cardiac Amyloidosis. Gulati JS, Pedretti R, Hendren N, Kozlitina J, Saelices L, Roth LR, Grodin JL Current heart failure reports 39945945 Curr Heart Fail Rep 2025 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/39945945
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores. Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS Nature structural & molecular biology 34518699 Nat Struct Mol Biol 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34518699
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pękała M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L Nature communications 38233397 Nat Commun 2024 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/38233397
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity. Nguyen BA, Afrin S, Yakubovska A, Singh V, Alicea JV, Kunach P, Singh P, Pekala M, Ahmed Y, Fernandez-Ramirez MDC, Hernandez LOC, Pedretti R, Bassett P, Wang L, Lemoff A, Villalon L, Kluve-Beckerman B, Saelices L bioRxiv : the preprint server for biology 38798361 bioRxiv 2024 May 14 https://www.ncbi.nlm.nih.gov/pubmed/38798361
O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology. Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR bioRxiv : the preprint server for biology 36945566 bioRxiv 2023 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/36945566
Update on Disease-Specific Biomarkers in Transthyretin Cardiac Amyloidosis. Hood CJ, Hendren NS, Pedretti R, Roth LR, Saelices L, Grodin JL Current heart failure reports 35930129 Curr Heart Fail Rep 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35930129
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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G Jr, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS Nature communications 37185252 Nat Commun 2023 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/37185252
Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis. Pedretti R, Wang L, Grodin JL, Masri A, Kelly J, Saelices L Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 39283068 Amyloid 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39283068
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Nguyen BA, Singh V, Afrin S, Singh P, Pekala M, Ahmed Y, Pedretti R, Canepa J, Lemoff A, Kluve-Beckerman B, Wydorski P, Chhapra F, Saelices L bioRxiv : the preprint server for biology 38496656 bioRxiv 2024 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/38496656
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Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122Δ variant. Ahmed Y, Nguyen BA, Afrin S, Singh V, Evers B, Singh P, Pedretti R, Wang L, Bassett P, Del Carmen Fernandez-Ramirez M, Pekala M, Kluve-Beckerman B, Saelices L bioRxiv : the preprint server for biology 38766262 bioRxiv 2024 May 10 https://www.ncbi.nlm.nih.gov/pubmed/38766262
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM. Fernandez-Ramirez MDC, Nguyen BA, Singh V, Afrin S, Evers B, Basset P, Wang L, Pękała M, Ahmed Y, Singh P, Canepa J, Wosztyl A, Li Y, Saelices L bioRxiv : the preprint server for biology 38798519 bioRxiv 2024 May 14 https://www.ncbi.nlm.nih.gov/pubmed/38798519
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Nguyen BA, Singh V, Afrin S, Singh P, Pekala M, Ahmed Y, Pedretti R, Canepa J, Lemoff A, Kluve-Beckerman B, Wydorski PM, Chhapra F, Saelices L Communications biology 39068302 Commun Biol 2024 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/39068302
Modeling Human Heart Development and Congenital Defects Using Organoids: How Close Are We? Jiang S, Feng W, Chang C, Li G Journal of cardiovascular development and disease 35621836 J Cardiovasc Dev Dis 2022 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/35621836
Keratin 19 (Krt19) is a novel marker gene for epicardial cells. Xu J, Deng Y, Li G Frontiers in genetics 38831775 Front Genet 2024 https://www.ncbi.nlm.nih.gov/pubmed/38831775
Cardiac Fibroblasts regulate myocardium and coronary vasculature development via the collagen signaling pathway. Deng Y, He Y, Xu J, He H, Zhang M, Li G bioRxiv : the preprint server for biology 39314489 bioRxiv 2025 May 27 https://www.ncbi.nlm.nih.gov/pubmed/39314489
Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis. Gan L, Zhao J, Yao P, Christopher TA, Lopez B, Lau WB, Koch W, Gao E, Ma X, Wang Y Redox biology 39740363 Redox Biol 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39740363
Heterogeneity and Functional Analysis of Cardiac Fibroblasts in Heart Development. Deng Y, He Y, Xu J, He H, Li G bioRxiv : the preprint server for biology 37577541 bioRxiv 2023 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/37577541
Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency. Feng W, Schriever H, Jiang S, Bais A, Wu H, Kostka D, Li G Communications biology 35488063 Commun Biol 2022 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/35488063
Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Feng W, Bais A, He H, Rios C, Jiang S, Xu J, Chang C, Kostka D, Li G Nature communications 36575170 Nat Commun 2022 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/36575170
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Neurocardiac Changes Preceding and During the Onset of Takotsubo Cardiomyopathy in the Cardiac Electrophysiology Laboratory. Thirumal R, Wittstein IS, Calkins H, DeMazumder D JACC. Clinical electrophysiology 35210091 JACC Clin Electrophysiol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35210091
Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias. Haghighi K, Gardner G, Vafiadaki E, Kumar M, Green LC, Ma J, Crocker JS, Koch S, Arvanitis DA, Bidwell P, Rubinstein J, van de Leur R, Doevendans PA, Akar FG, Tranter M, Wang HS, Sadayappan S, DeMazumder D, Sanoudou D, Hajjar RJ, Stillitano F, Kranias EG Journal of personalized medicine 34204946 J Pers Med 2021 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/34204946
Artificial Intelligence, Wearables and Remote Monitoring for Heart Failure: Current and Future Applications. Gautam N, Ghanta SN, Mueller J, Mansour M, Chen Z, Puente C, Ha YM, Tarun T, Dhar G, Sivakumar K, Zhang Y, Halimeh AA, Nakarmi U, Al-Kindi S, DeMazumder D, Al'Aref SJ Diagnostics (Basel, Switzerland) 36552971 Diagnostics (Basel) 2022 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/36552971
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Cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity. Dey S, Joshi P, O'Rourke B, Estes S, DeMazumder D bioRxiv : the preprint server for biology 36778270 bioRxiv 2023 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/36778270
Contemporary Applications of Machine Learning for Device Therapy in Heart Failure. Gautam N, Ghanta SN, Clausen A, Saluja P, Sivakumar K, Dhar G, Chang Q, DeMazumder D, Rabbat MG, Greene SJ, Fudim M, Al'Aref SJ JACC. Heart failure 36049812 JACC Heart Fail 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36049812
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Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, Niroula A, McConkey ME, Sandoval B, Miller BC, Shi W, Viswanathan K, Leventhal M, Werner L, Moll M, Cade BE, Barr RG, Correa A, Cupples LA, Gharib SA, Jain D, Gogarten SM, Lange LA, London SJ, Manichaikul A, O'Connor GT, Oelsner EC, Redline S, Rich SS, Rotter JI, Ramachandran V, Yu B, Sholl L, Neuberg D, Jaiswal S, Levy BD, Owen CA, Natarajan P, Silverman EK, van Galen P, Tesfaigzi Y, Cho MH, Ebert BL, COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium Blood 34855941 Blood 2022 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/34855941
Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MM, Bick AG, Niroula A, Yu B, Gibson C, Griffin G, Morrison AC, Psaty BM, Longstreth WT, Bis JC, Rich SS, Rotter JI, Tracy RP, Correa A, Seshadri S, Johnson A, Collins JM, Hayden KM, Madsen TE, Ballantyne CM, Jaiswal S, Ebert BL, Kooperberg C, Manson JE, Whitsel EA, NHLBI Trans-Omics for Precision Medicine Program, Natarajan P, Reiner AP Stroke 34743536 Stroke 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34743536
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate. Mack TM, Raddatz MA, Pershad Y, Nachun DC, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Kenny EE, Loos RJF, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Cho MH, DeMeo DL, Levy D, Johnson AD, Mathias RA, Yanek LR, Heckbert SR, Smith NL, Wiggins KL, Raffield LM, Carson AP, Rotter JI, Rich SS, Manichaikul AW, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Roden DM, Kooperberg C, Auer PL, Desai P, Blackwell TW, Smith AV, Reiner AP, Jaiswal S, Weinstock JS, Bick AG Nature aging 38834882 Nat Aging 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38834882
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The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, Cade BE, Gilliland FD, Chen Z, Gauderman WJ, Kumar R, Grammer L, Schleimer RP, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Weiss ST, Lasky-Su J, DeMeo DL, Palmer ND, Freedman BI, Bowden DW, Cho MH, Vasan RS, Johnson AD, Yanek LR, Becker LC, Kardia S, He J, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Manichaikul AW, Konkle BA, Johnsen JM, Wheeler MM, Custer BS, Duggirala R, Curran JE, Blangero J, Gui H, Xiao S, Williams LK, Meyers DA, Li X, Ortega V, McGarvey S, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Darbar D, Roden D, Albert C, Kooperberg C, Desai P, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Mathias R, Natarajan P, Jaiswal S, Reiner AP, Bick AG, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Science advances 37126548 Sci Adv 2023 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/37126548
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Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood. Schuermans A, Nakao T, Ruan Y, Koyama S, Yu Z, Uddin MM, Haidermota S, Hornsby W, Lewandowski AJ, Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC Journal of the American Heart Association 37345823 J Am Heart Assoc 2023 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/37345823
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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL The Journal of experimental medicine 34698806 J Exp Med 2021 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/34698806
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Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease. Gumuser ED, Schuermans A, Cho SMJ, Sporn ZA, Uddin MM, Paruchuri K, Nakao T, Yu Z, Haidermota S, Hornsby W, Weeks LD, Niroula A, Jaiswal S, Libby P, Ebert BL, Bick AG, Natarajan P, Honigberg MC Journal of the American College of Cardiology 37197843 J Am Coll Cardiol 2023 May 23 https://www.ncbi.nlm.nih.gov/pubmed/37197843
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Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self. Chowdhury RR, D'Addabbo J, Huang X, Veizades S, Sasagawa K, Louis DM, Cheng P, Sokol J, Jensen A, Tso A, Shankar V, Wendel BS, Bakerman I, Liang G, Koyano T, Fong R, Nau AN, Ahmad H, Gopakumar J, Wirka R, Lee AS, Boyd J, Woo YJ, Quertermous T, Gulati GS, Jaiswal S, Chien YH, Chan CKF, Davis MM, Nguyen PK Circulation research 35430876 Circ Res 2022 May 13 https://www.ncbi.nlm.nih.gov/pubmed/35430876
Clonal haematopoiesis and atherosclerotic cardiovascular disease. Ahmad H, Jaiswal S Nature reviews. Cardiology 37169832 Nat Rev Cardiol 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37169832
Prediction of risk for myeloid malignancy in clonal hematopoiesis. Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL NEJM evidence 37483562 NEJM Evid 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37483562
Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. Yu Z, Fidler TP, Ruan Y, Vlasschaert C, Nakao T, Uddin MM, Mack T, Niroula A, Heimlich JB, Zekavat SM, Gibson CJ, Griffin GK, Wang Y, Peloso GM, Heard-Costa N, Levy D, Vasan RS, Aguet F, Ardlie KG, Taylor KD, Rich SS, Rotter JI, Libby P, Jaiswal S, Ebert BL, Bick AG, Tall AR, Natarajan P The Journal of clinical investigation 37498674 J Clin Invest 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37498674
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, Sharber B, Silver AJ, Xu Y, Savona M, Gibson C, Lanktree MB, Rauh MJ, Ebert BL, Natarajan P, Jaiswal S, Bick AG Blood 36652671 Blood 2023 May 4 https://www.ncbi.nlm.nih.gov/pubmed/36652671
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics. Uddin MM, Zhou Y, Bick AG, Burugula BB, Jaiswal S, Desai P, Honigberg MC, Love SA, Barac A, Hayden KM, Manson JE, Whitsel EA, Kooperberg C, Natarajan P, Reiner AP, Kitzman JO Immunity & ageing : I & A 35610705 Immun Ageing 2022 May 24 https://www.ncbi.nlm.nih.gov/pubmed/35610705
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia. Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M Blood 36130297 Blood 2022 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/36130297
Clonal hematopoiesis is associated with protection from Alzheimer's disease. Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S Nature medicine 37322115 Nat Med 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37322115
In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH Nature communications 34257302 Nat Commun 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/34257302
In utero hematopoietic cell transplantation leads to sustained engraftment in a mouse model of Fanconi anemia. Dave A, Liu S, Riley JS, Bose S, Luks V, Berkowitz C, Menon P, Jung S, Li H, Kurre P, Peranteau WH Blood advances 37906519 Blood Adv 2024 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/37906519
Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs. Whittaker MN, Testa LC, Brooks DL, Quigley A, Said H, Dwivedi G, Jindal I, Volpp D, Qu P, Wang JZ, Levine MA, Ahrens-Nicklas RC, Li Q, Musunuru K, Alameh MG, Peranteau WH, Wang X bioRxiv : the preprint server for biology 38712058 bioRxiv 2025 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/38712058
InUtero Gene Therapy: Progress and Challenges. Bose SK, Menon P, Peranteau WH Trends in molecular medicine 34176774 Trends Mol Med 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34176774
Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement. Sagar R, Almeida-Porada G, Blakemore K, Chan JKY, Choolani M, Götherström C, Jaulent A, MacKenzie TC, Mattar C, Porada CD, Peranteau WH, Schneider H, Shaw SW, Waddington SN, Westgren M, David AL Molecular therapy : the journal of the American Society of Gene Therapy 33069884 Mol Ther 2020 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/33069884
Molecular and Cellular In Utero Therapy. Berkowitz CL, Luks VL, Puc M, Peranteau WH Clinics in perinatology 36328600 Clin Perinatol 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36328600
Comment on: Premature delivery in the domestic sow in response to in utero delivery of AAV9 to fetal piglets. Dave A, Berkowitz CL, Luks VL, White BM, Palanki R, Carpenter MD, Riley JS, Bose SK, Li H, Li L, Menon PV, Teerdhala S, Ebrahimi M, Zoltick PW, Peranteau WH Gene therapy 36918654 Gene Ther 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36918654
Fetal allotransplant recipients are resistant to graft-versus-host disease. Riley JS, McClain LE, Stratigis JD, Coons BE, Bose SK, Dave A, White BM, Li H, Loukogeorgakis SP, Fachin CG, Dias AIBS, Flake AW, Peranteau WH Experimental hematology 36535408 Exp Hematol 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36535408
In utero pulse injection of isotopic amino acids quantifies protein turnover rates during murine fetal development. Baeza J, Coons BE, Lin Z, Riley J, Mendoza M, Peranteau WH, Garcia BA bioRxiv : the preprint server for biology 37293076 bioRxiv 2023 May 21 https://www.ncbi.nlm.nih.gov/pubmed/37293076
Immune modulation permits tolerance and engraftment in a murine model of late-gestation transplantation. Riley JS, Berkowitz CL, Luks VL, Dave A, Cyril-Olutayo MC, Pogoriler J, Flake AW, Abdulmalik O, Peranteau WH Blood advances 38941538 Blood Adv 2024 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/38941538
Preexisting maternal immunity to AAV but not Cas9 impairs in utero gene editing in mice. Riley JS, Luks VL, Berkowitz CL, Dumitru AM, Kus NJ, Dave A, Menon P, De Paepe ME, Jain R, Li L, Dugoff L, Teefey CP, Alameh MG, Zoltick PW, Peranteau WH The Journal of clinical investigation 38950310 J Clin Invest 2024 May 9 https://www.ncbi.nlm.nih.gov/pubmed/38950310
Prenatal Gene Therapy for Metabolic Disorders. Coons B, Peranteau WH Clinical obstetrics and gynecology 34652302 Clin Obstet Gynecol 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/34652302
The Future of In Utero Gene Therapy. Peranteau WH, Flake AW Molecular diagnosis & therapy 32020561 Mol Diagn Ther 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32020561
Foetal genome editing. Bose SK, Kennedy K, Peranteau WH Current opinion in obstetrics & gynecology 36924409 Curr Opin Obstet Gynecol 2023 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/36924409
Fetal gene therapy. Waddington SN, Peranteau WH, Rahim AA, Boyle AK, Kurian MA, Gissen P, Chan JKY, David AL Journal of inherited metabolic disease 37470194 J Inherit Metab Dis 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37470194
The emerging role of extracellular vesicles in bronchopulmonary dysplasia. Ransom MA, Blatt AM, Pua HH, Sucre JMS American journal of physiology. Lung cellular and molecular physiology 38469633 Am J Physiol Lung Cell Mol Physiol 2024 May 1 https://www.ncbi.nlm.nih.gov/pubmed/38469633
Secret messengers: Extracellular RNA communication in the immune system. Nation GK, Saffold CE, Pua HH Immunological reviews 34542176 Immunol Rev 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34542176
Developmental trajectory of extracellular vesicle characteristics from the lungs of preterm infants. Ransom MA, Bunn KE, Negretti NM, Jetter CS, Bressman ZJ, Sucre JMS, Pua HH American journal of physiology. Lung cellular and molecular physiology 36719083 Am J Physiol Lung Cell Mol Physiol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36719083
Transcriptome Complexity Disentangled: A Regulatory Molecules Approach. Asiaee A, Abrams ZB, Pua HH, Coombes KR bioRxiv : the preprint server for biology 37131792 bioRxiv 2025 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/37131792
Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, Van Kaer L Proceedings of the National Academy of Sciences of the United States of America 36574710 Proc Natl Acad Sci U S A 2023 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/36574710
RNA regulation in immunity. Pua H, Ansel KM Immunological reviews 34816450 Immunol Rev 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34816450
Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution. von Lersner AK, Fernandes F, Ozawa PMM, Jackson M, Masureel M, Ho H, Lima SM, Vagner T, Sung BH, Wehbe M, Franze K, Pua H, Wilson JT, Irish JM, Weaver AM, Di Vizio D, Zijlstra A ACS nano 38578701 ACS Nano 2024 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/38578701
Extracellular RNA in oncogenesis, metastasis and drug resistance. Nelson H, Qu S, Franklin JL, Liu Q, Pua HH, Vickers KC, Weaver AM, Coffey RJ, Patton JG RNA biology 39107918 RNA Biol 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/39107918
Extracellular vesicles: mediators of intercellular communication in tissue injury and disease. Berumen Sánchez G, Bunn KE, Pua HH, Rafat M Cell communication and signaling : CCS 34656117 Cell Commun Signal 2021 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/34656117
MicroRNAs in Macrophages: Regulators of Activation and Function. Sprenkle NT, Serezani CH, Pua HH Journal of immunology (Baltimore, Md. : 1950) 36724439 J Immunol 2023 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/36724439
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Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes. Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V Frontiers in physiology 38179138 Front Physiol 2023 https://www.ncbi.nlm.nih.gov/pubmed/38179138
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function. Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V Circulation research 33044128 Circ Res 2020 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/33044128
Single Cell Multi-Omics of an iPSC Model of Human Sinoatrial Node Development Reveals Genetic Determinants of Heart Rate and Arrhythmia Susceptibility. Engel JL, Zhang X, Lu DR, Vila OF, Arias V, Lee J, Hale C, Hsu YH, Li CM, Wu RS, Vedantham V, Ang YS bioRxiv : the preprint server for biology 37425707 bioRxiv 2023 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/37425707
Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node. Mandla R, Jung C, Vedantham V Frontiers in physiology 34335313 Front Physiol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34335313
Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D Circulation 35938400 Circulation 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/35938400
Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes. Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V bioRxiv : the preprint server for biology 36747643 bioRxiv 2023 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/36747643
Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1. Garbutt TA, Wang Z, Wang H, Ma H, Ruan H, Dong Y, Xie Y, Tan L, Phookan R, Stouffer JA, Vedantham V, Yang Y, Qian L, Liu J Circulation 38223978 Circulation 2024 May 7 https://www.ncbi.nlm.nih.gov/pubmed/38223978
Combining simulations and experiments for the molecular engineering of multifunctional collagen mimetic peptide-based materials. Hilderbrand AM, Taylor PA, Stanzione F, LaRue M, Guo C, Jayaraman A, Kloxin AM Soft matter 33434255 Soft Matter 2021 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/33434255
Effects of solvent conditions on the self-assembly of heterotrimeric collagen-like peptide (CLP) triple helices: a coarse-grained simulation study. Taylor PA, Kronenberger S, Kloxin AM, Jayaraman A Soft matter 37340986 Soft Matter 2023 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/37340986
Engineered hydrogels for mechanobiology. Blache U, Ford EM, Ha B, Rijns L, Chaudhuri O, Dankers PYW, Kloxin AM, Snedeker JG, Gentleman E Nature reviews. Methods primers 37461429 Nat Rev Methods Primers 2022 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/37461429
Dynamic bioinspired coculture model for probing ER(+) breast cancer dormancy in the bone marrow niche. Pradhan L, Moore D, Ovadia EM, Swedzinski SL, Cossette T, Sikes RA, van Golen K, Kloxin AM Science advances 36888709 Sci Adv 2023 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/36888709
Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19. Jarai BM, Stillman Z, Bomb K, Kloxin AM, Fromen CA ACS biomaterials science & engineering 33356134 ACS Biomater Sci Eng 2021 May 10 https://www.ncbi.nlm.nih.gov/pubmed/33356134
Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials. Sutherland BP, LeValley PJ, Bischoff DJ, Kloxin AM, Kloxin CJ Chemical communications (Cambridge, England) 32820777 Chem Commun (Camb) 2020 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/32820777
On the path to predicting immune responses in the lung: Modeling the pulmonary innate immune system at the air-liquid interface (ALI). Graf J, Trautmann-Rodriguez M, Sabnis S, Kloxin AM, Fromen CA European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 37770004 Eur J Pharm Sci 2023 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/37770004
Bridging the gender gap in autoimmunity with T-cell-targeted biomaterials. López Ruiz A, Slaughter ED, Kloxin AM, Fromen CA Current opinion in biotechnology 38377884 Curr Opin Biotechnol 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38377884
Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations. Cassel SE, Huntington BM, Chen W, Lei P, Andreadis ST, Kloxin AM APL bioengineering 38938687 APL Bioeng 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38938687
Rational Design of Hydrogel Networks with Dynamic Mechanical Properties to Mimic Matrix Remodeling. Wiley KL, Sutherland BP, Ogunnaike BA, Kloxin AM Advanced healthcare materials 34936227 Adv Healthc Mater 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/34936227
Harnessing multifunctional collagen mimetic peptides to create bioinspired stimuli responsive hydrogels for controlled cell culture. Ford EM, Hilderbrand AM, Kloxin AM Journal of materials chemistry. B 39211975 J Mater Chem B 2024 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/39211975
Rapid Production of Multifunctional Self-Assembling Peptides for Incorporation and Visualization within Hydrogel Biomaterials. Ford EM, Kloxin AM ACS biomaterials science & engineering 34283566 ACS Biomater Sci Eng 2021 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/34283566
Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels. Wodzanowski KA, Cassel SE, Grimes CL, Kloxin AM Bioorganic & medicinal chemistry letters 32223923 Bioorg Med Chem Lett 2020 May 15 https://www.ncbi.nlm.nih.gov/pubmed/32223923
On-demand and tunable dual wavelength release of antibody using light-responsive hydrogels. LeValley PJ, Sutherland BP, Jaje J, Gibbs S, Jones M, Gala R, Kloxin CJ, Kiick KL, Kloxin AM ACS applied bio materials 34327309 ACS Appl Bio Mater 2020 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/34327309
Multiscale Invasion Assay for Probing Macrophage Response to Gram-Negative Bacteria. Wodzanowski KA, Caplan JL, Kloxin AM, Grimes CL Frontiers in chemistry 35242744 Front Chem 2022 https://www.ncbi.nlm.nih.gov/pubmed/35242744
Systematic d-Amino Acid Substitutions to Control Peptide and Hydrogel Degradation in Cellular Microenvironments. Bomb K, Zhang Q, Ford EM, Fromen CA, Kloxin AM ACS macro letters 37195203 ACS Macro Lett 2023 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/37195203
Impact of collagen-like peptide (CLP) heterotrimeric triple helix design on helical thermal stability and hierarchical assembly: a coarse-grained molecular dynamics simulation study. Taylor PA, Kloxin AM, Jayaraman A Soft matter 35380571 Soft Matter 2022 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/35380571
Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function. Bomb K, Pradhan L, Zhang Q, Jarai BM, Bhattacharjee A, Burris DL, Kloxin AM, Fromen CA Biomaterials science 36018297 Biomater Sci 2022 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/36018297
Microgels Formed by Spontaneous Click Chemistries Utilizing Microfluidic Flow Focusing for Cargo Release in Response to Endogenous or Exogenous Stimuli. LeValley PJ, Parsons AL, Sutherland BP, Kiick KL, Oakey JS, Kloxin AM Pharmaceutics 35631649 Pharmaceutics 2022 May 15 https://www.ncbi.nlm.nih.gov/pubmed/35631649
Multiomic Analysis and CRISPR Perturbation Screens Identify Endothelial Cell Programs and Novel Therapeutic Targets for Coronary Artery Disease. Gupta RM, Schnitzler GR, Fang S, Lee-Kim VS, Barry A Arteriosclerosis, thrombosis, and vascular biology 36994731 Arterioscler Thromb Vasc Biol 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36994731
The Aging Aorta: Are We Only as Old as Our Endothelium? Gupta RM, Plutzky J Arteriosclerosis, thrombosis, and vascular biology 35080899 Arterioscler Thromb Vasc Biol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35080899
The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies. Pepin ME, Gupta RM The American journal of pathology 37827214 Am J Pathol 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/37827214
Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease. Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K Communications biology 38216744 Commun Biol 2024 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/38216744
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses. Wang M, Lee-Kim VS, Atri DS, Elowe NH, Yu J, Garvie CW, Won HH, Hadaya JE, MacDonald BT, Trindade K, Melander O, Rader DJ, Natarajan P, Kathiresan S, Kaushik VK, Khera AV, Gupta RM Circulation. Genomic and precision medicine 34592835 Circ Genom Precis Med 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34592835
Causal Gene Confusion: The Complicated EDN1/PHACTR1 Locus for Coronary Artery Disease. Gupta RM Arteriosclerosis, thrombosis, and vascular biology 35387481 Arterioscler Thromb Vasc Biol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35387481
Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases. Weeks EM, Ulirsch JC, Cheng NY, Trippe BL, Fine RS, Miao J, Patwardhan TA, Kanai M, Nasser J, Fulco CP, Tashman KC, Aguet F, Li T, Ordovas-Montanes J, Smillie CS, Biton M, Shalek AK, Ananthakrishnan AN, Xavier RJ, Regev A, Gupta RM, Lage K, Ardlie KG, Hirschhorn JN, Lander ES, Engreitz JM, Finucane HK Nature genetics 37443254 Nat Genet 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37443254
Missing Regulation Between Genetic Association and Transcriptional Abundance for Hypercholesterolemia Genes. Hakim A, Connally NJ, Schnitzler GR, Cho MH, Jiang ZG, Sunyaev SR, Gupta RM Genes 39858631 Genes (Basel) 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39858631
Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque. Gupta RM, Libby P, Barton M Atherosclerosis 31810569 Atherosclerosis 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31810569
The March of Monocytes in Atherosclerosis: One Cell at a Time. Gupta RM, Lee-Kim VS, Libby P Circulation research 32379573 Circ Res 2020 May 8 https://www.ncbi.nlm.nih.gov/pubmed/32379573
CRISPR-Cas9 Genome Editing of Primary Human Vascular Cells In Vitro. Atri DS, Lee-Kim VS, Vellarikkal SK, Sias-Garcia O, Yanamandala M, Schniztler GR, Gupta RM Current protocols 34748284 Curr Protoc 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34748284
Convergence of coronary artery disease genes onto endothelial cell programs. Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM Nature 38326615 Nature 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38326615
Polygenic prediction of preeclampsia and gestational hypertension. Honigberg MC, Truong B, Khan RR, Xiao B, Bhatta L, Vy HMT, Guerrero RF, Schuermans A, Selvaraj MS, Patel AP, Koyama S, Cho SMJ, Vellarikkal SK, Trinder M, Urbut SM, Gray KJ, Brumpton BM, Patil S, Zöllner S, Antopia MC, Saxena R, Nadkarni GN, Do R, Yan Q, Pe'er I, Verma SS, Gupta RM, Haas DM, Martin HC, van Heel DA, Laisk T, Natarajan P Nature medicine 37248299 Nat Med 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37248299
Vagal sensory neurons and gut-brain signaling. Yu CD, Xu QJ, Chang RB Current opinion in neurobiology 32380360 Curr Opin Neurobiol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32380360
The Coding Logic of Interoception. Wang RL, Chang RB Annual review of physiology 38061018 Annu Rev Physiol 2024 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/38061018
A multidimensional coding architecture of the vagal interoceptive system. Zhao Q, Yu CD, Wang R, Xu QJ, Dai Pra R, Zhang L, Chang RB Nature 35296859 Nature 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35296859
Differential developmental blueprints of organ-intrinsic nervous systems. Hsu IU, Lin Y, Guo Y, Xu QJ, Shao Y, Wang RL, Yin D, Zhao J, Young LH, Zhao H, Zhang L, Chang RB bioRxiv : the preprint server for biology 38168446 bioRxiv 2023 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/38168446
Cardiovascular Brain Circuits. Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht AJR Circulation research 37228235 Circ Res 2023 May 26 https://www.ncbi.nlm.nih.gov/pubmed/37228235
The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine. Rajendran PS, Hadaya J, Khalsa SS, Yu C, Chang R, Shivkumar K Seminars in cell & developmental biology 36641366 Semin Cell Dev Biol 2024 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36641366
Regulation of Cardiac Function by the Autonomic Nervous System. Hafez OA, Chang RB Physiology (Bethesda, Md.) 39585760 Physiology (Bethesda) 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/39585760
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Ma S, Zhang B, LaFave LM, Earl AS, Chiang Z, Hu Y, Ding J, Brack A, Kartha VK, Tay T, Law T, Lareau C, Hsu YC, Regev A, Buenrostro JD Cell 33098772 Cell 2020 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/33098772
Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. Hu Y, Ma S, Kartha VK, Duarte FM, Horlbeck M, Zhang R, Shrestha R, Labade A, Kletzien H, Meliki A, Castillo A, Durand N, Mattei E, Anderson LJ, Tay T, Earl AS, Shoresh N, Epstein CB, Wagers A, Buenrostro JD bioRxiv : the preprint server for biology 37034577 bioRxiv 2023 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/37034577
A transcription factor atlas of directed differentiation. Joung J, Ma S, Tay T, Geiger-Schuller KR, Kirchgatterer PC, Verdine VK, Guo B, Arias-Garcia MA, Allen WE, Singh A, Kuksenko O, Abudayyeh OO, Gootenberg JS, Fu Z, Macrae RK, Buenrostro JD, Regev A, Zhang F Cell 36608654 Cell 2023 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/36608654
scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution. Hingerl JC, Martens LD, Karollus A, Manz T, Buenrostro JD, Theis FJ, Gagneur J bioRxiv : the preprint server for biology 39345504 bioRxiv 2025 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/39345504
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues. Zhao T, Chiang ZD, Morriss JW, LaFave LM, Murray EM, Del Priore I, Meli K, Lareau CA, Nadaf NM, Li J, Earl AS, Macosko EZ, Jacks T, Buenrostro JD, Chen F Nature 34912115 Nature 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34912115
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T Cancer cell 32707078 Cancer Cell 2020 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/32707078
Functional inference of gene regulation using single-cell multi-omics. Kartha VK, Duarte FM, Hu Y, Ma S, Chew JG, Lareau CA, Earl A, Burkett ZD, Kohlway AS, Lebofsky R, Buenrostro JD Cell genomics 36204155 Cell Genom 2022 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/36204155
Multiscale footprints reveal the organization of cis-regulatory elements. Hu Y, Horlbeck MA, Zhang R, Ma S, Shrestha R, Kartha VK, Duarte FM, Hock C, Savage RE, Labade A, Kletzien H, Meliki A, Castillo A, Durand NC, Mattei E, Anderson LJ, Tay T, Earl AS, Shoresh N, Epstein CB, Wagers AJ, Buenrostro JD Nature 39843737 Nature 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39843737
A microRNA expression and regulatory element activity atlas of the mouse immune system. Rose SA, Wroblewska A, Dhainaut M, Yoshida H, Shaffer JM, Bektesevic A, Ben-Zvi B, Rhoads A, Kim EY, Yu B, Lavin Y, Merad M, Buenrostro JD, Brown BD, Immunological Genome Consortium Nature immunology 34099919 Nat Immunol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34099919
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes. Hsu J, Reilly A, Hayes BJ, Clough CA, Konnick EQ, Torok-Storb B, Gulsuner S, Wu D, Becker PS, Keel SB, Abkowitz JL, Doulatov S Blood 31010849 Blood 2019 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/31010849
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function. Reilly A, Philip Creamer J, Stewart S, Stolla MC, Wang Y, Du J, Wellington R, Busch S, Estey EH, Becker PS, Fang M, Keel SB, Abkowitz JL, Soma LA, Ma J, Duan Z, Doulatov S Cell stem cell 35278369 Cell Stem Cell 2022 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/35278369
R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts. Liu ZS, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken AJ, Bonner EA, Hanson BK, Sarchi M, Takashima K, Zong D, Corral VM, Nguyen E, Yoo J, Chiraphapphaiboon W, Leibson C, McMahon MC, Rai S, Swisher EM, Sachs Z, Chatla S, Stirewalt DL, Deeg HJ, Skorski T, Papapetrou EP, Walter MJ, Graubert TA, Doulatov S, Lee SC, Nguyen HD Cancer research 37967363 Cancer Res 2024 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/37967363
Induced pluripotent stem cell models of myeloid malignancies and clonal evolution. Reilly A, Doulatov S Stem cell research 33592565 Stem Cell Res 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33592565
ATG4A regulates human erythroid maturation and mitochondrial clearance. Stolla MC, Reilly A, Bergantinos R, Stewart S, Thom N, Clough CA, Wellington RC, Stolitenko R, Abkowitz JL, Doulatov S Blood advances 35443024 Blood Adv 2022 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/35443024
Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome. Clough CA, Pangallo J, Sarchi M, Ilagan JO, North K, Bergantinos R, Stolla MC, Naru J, Nugent P, Kim E, Stirewalt DL, Subramaniam AR, Abdel-Wahab O, Abkowitz JL, Bradley RK, Doulatov S Blood 34861039 Blood 2022 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/34861039
Induced pluripotent stem cell line (SDQLCHi041-A) from a male patient with mucopolysaccharidosis type IIIB. Guan J, Tian G, Dong R, Zhang H, Yang X, Li Y, Gai Z, Liu Y Stem cell research 33550137 Stem Cell Res 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33550137
Studying clonal evolution of myeloid malignancies using induced pluripotent stem cells. Doulatov S, Papapetrou EP Current opinion in hematology 33264225 Curr Opin Hematol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33264225
Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition. Sarchi M, Clough CA, Crosse EI, Kim J, Baquero Galvis LD, Aydinyan N, Wellington R, Yang F, Gallì A, Creamer JP, Stewart S, Bradley RK, Malcovati L, Doulatov S Blood cancer discovery 38856693 Blood Cancer Discov 2024 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/38856693
Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells. Wellington R, Cheng X, Campbell CA, Trapnell C, Espin-Palazon R, Hadland B, Doulatov S bioRxiv : the preprint server for biology 39386462 bioRxiv 2024 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/39386462
Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells. Jiang CL, Goyal Y, Jain N, Wang Q, Truitt RE, Coté AJ, Emert B, Mellis IA, Kiani K, Yang W, Jain R, Raj A Genome biology 35382863 Genome Biol 2022 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/35382863
A LAMP sequencing approach for high-throughput co-detection of SARS-CoV-2 and influenza virus in human saliva. Warneford-Thomson R, Shah PP, Lundgren P, Lerner J, Morgan J, Davila A, Abella BS, Zaret K, Schug J, Jain R, Thaiss CA, Bonasio R eLife 35532013 Elife 2022 May 9 https://www.ncbi.nlm.nih.gov/pubmed/35532013
Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE Proceedings of the National Academy of Sciences of the United States of America 30782824 Proc Natl Acad Sci U S A 2019 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/30782824
A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL Circulation research 31822208 Circ Res 2020 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/31822208
Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors. Smith CL, Lan Y, Jain R, Epstein JA, Poleshko A Science advances 34559565 Sci Adv 2021 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/34559565
Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains. See K, Lan Y, Rhoades J, Jain R, Smith CL, Epstein JA Development (Cambridge, England) 30723106 Development 2019 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/30723106
Picking Winners and Losers: Cell Competition in Tissue Development and Homeostasis. Kim W, Jain R Trends in genetics : TIG 32418713 Trends Genet 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32418713
InterLINCing Chromatin Organization and Mechanobiology in Laminopathies. Shah PP, Santini GT, Shen KM, Jain R Current cardiology reports 37052760 Curr Cardiol Rep 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37052760
Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression. Gozalo A, Duke A, Lan Y, Pascual-Garcia P, Talamas JA, Nguyen SC, Shah PP, Jain R, Joyce EF, Capelson M Molecular cell 31784359 Mol Cell 2020 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/31784359
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina. Kiseleva AA, Cheng YC, Smith CL, Katz RA, Poleshko A Nucleus (Austin, Tex.) 36633363 Nucleus 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/36633363
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R Cell stem cell 33529599 Cell Stem Cell 2021 May 6 https://www.ncbi.nlm.nih.gov/pubmed/33529599
H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. Poleshko A, Smith CL, Nguyen SC, Sivaramakrishnan P, Wong KG, Murray JI, Lakadamyali M, Joyce EF, Jain R, Epstein JA eLife 31573510 Elife 2019 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/31573510
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. Berg DA, Su Y, Jimenez-Cyrus D, Patel A, Huang N, Morizet D, Lee S, Shah R, Ringeling FR, Jain R, Epstein JA, Wu QF, Canzar S, Ming GL, Song H, Bond AM Cell 30929900 Cell 2019 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/30929900
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate. Shiraishi K, Shah PP, Morley MP, Loebel C, Santini GT, Katzen J, Basil MC, Lin SM, Planer JD, Cantu E, Jones DL, Nottingham AN, Li S, Cardenas-Diaz FL, Zhou S, Burdick JA, Jain R, Morrisey EE Cell 36870331 Cell 2023 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/36870331
Aberrant chromatin organization at the nexus of laminopathy disease pathways. Santini GT, Shah PP, Karnay A, Jain R Nucleus (Austin, Tex.) 36503349 Nucleus 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36503349
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype. Shah PP, Keough KC, Gjoni K, Santini GT, Abdill RJ, Wickramasinghe NM, Dundes CE, Karnay A, Chen A, Salomon REA, Walsh PJ, Nguyen SC, Whalen S, Joyce EF, Loh KM, Dubois N, Pollard KS, Jain R Genome biology 36691074 Genome Biol 2023 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/36691074
Advanced Human BBB-on-a-Chip: A New Platform for Alzheimer's Disease Studies. Yoon JK, Kim J, Shah Z, Awasthi A, Mahajan A, Kim Y Advanced healthcare materials 34075728 Adv Healthc Mater 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34075728
Detecting the functional complexities between high-density lipoprotein mimetics. Sei YJ, Ahn J, Kim T, Shin E, Santiago-Lopez AJ, Jang SS, Jeon NL, Jang YC, Kim Y Biomaterials 29653287 Biomaterials 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29653287
Nanotherapeutics Engineered to Cross the Blood-Brain Barrier for Advanced Drug Delivery to the Central Nervous System. Kim J, Ahn SI, Kim Y Journal of industrial and engineering chemistry (Seoul, Korea) 31588177 J Ind Eng Chem 2019 May 25 https://www.ncbi.nlm.nih.gov/pubmed/31588177
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance. Lim J, Ching H, Yoon JK, Jeon NL, Kim Y Nano convergence 33846849 Nano Converg 2021 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/33846849
Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma. Kim J, Dey A, Malhotra A, Liu J, Ahn SI, Sei YJ, Kenney AM, MacDonald TJ, Kim Y Proceedings of the National Academy of Sciences of the United States of America 32934143 Proc Natl Acad Sci U S A 2020 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/32934143
Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors. Lee Y, Choi JJ, Ahn SI, Lee NH, Han WM, Mohiuddin M, Shin EJ, Wood L, Park KD, Kim Y, Jang YC Advanced functional materials 38053980 Adv Funct Mater 2020 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/38053980
Polymeric Nanoparticles Controlled by On-Chip Self-Assembly Enhance Cancer Treatment Effectiveness. Jung S, Lee J, Lim J, Suh J, Kim T, Ahn J, Kim WJ, Kim Y Advanced healthcare materials 33073526 Adv Healthc Mater 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33073526
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity. Liu K, Li D, Hao G, McCaffary D, Neely O, Woodward L, Ioannides D, Lu CJ, Brescia M, Zaccolo M, Tandri H, Ajijola OA, Ardell JL, Shivkumar K, Paterson DJ JCI insight 29720569 JCI Insight 2018 May 3 https://www.ncbi.nlm.nih.gov/pubmed/29720569
Managing ventricular arrhythmias after failed catheter ablation: Interrupting the reentrant loop of repeat ablation. Yoshie K, Ajijola OA Heart rhythm 28958931 Heart Rhythm 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28958931
Estimating Cardiac Sympathetic Activity From Subcutaneous Nerve Recordings: More Than Skin Deep? Dusi V, Ajijola OA JACC. Clinical electrophysiology 29798800 JACC Clin Electrophysiol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29798800
Coronary Sinus Neuropeptide Y Levels and Adverse Outcomes in Patients With Stable Chronic Heart Failure. Ajijola OA, Chatterjee NA, Gonzales MJ, Gornbein J, Liu K, Li D, Paterson DJ, Shivkumar K, Singh JP, Herring N JAMA cardiology 31876927 JAMA Cardiol 2020 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/31876927
Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction. Yoshie K, Rajendran PS, Massoud L, Mistry J, Swid MA, Wu X, Sallam T, Zhang R, Goldhaber JI, Salavatian S, Ajijola OA JCI insight 31846438 JCI Insight 2020 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/31846438
Aorticorenal ganglion as a novel target for renal neuromodulation. Hori Y, Temma T, Wooten C, Sobowale C, Tahmasian S, Chan C, Swid MA, Zuckerman JE, Peacock W, Ajijola OA Heart rhythm 34182169 Heart Rhythm 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34182169
Cardiac vanilloid receptor-1 afferent depletion enhances stellate ganglion neuronal activity and efferent sympathetic response to cardiac stress. Yoshie K, Rajendran PS, Massoud L, Kwon O, Tadimeti V, Salavatian S, Ardell JL, Shivkumar K, Ajijola OA American journal of physiology. Heart and circulatory physiology 29351450 Am J Physiol Heart Circ Physiol 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29351450
Inflammation, oxidative stress, and glial cell activation characterize stellate ganglia from humans with electrical storm. Ajijola OA, Hoover DB, Simerly TM, Brown TC, Yanagawa J, Biniwale RM, Lee JM, Sadeghi A, Khanlou N, Ardell JL, Shivkumar K JCI insight 28931760 JCI Insight 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28931760
The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade. Kalla M, Hao G, Tapoulal N, Tomek J, Liu K, Woodward L, ‘Oxford Acute Myocardial Infarction (OxAMI) Study’, Dall'Armellina E, Banning AP, Choudhury RP, Neubauer S, Kharbanda RK, Channon KM, Ajijola OA, Shivkumar K, Paterson DJ, Herring N European heart journal 31834357 Eur Heart J 2020 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/31834357
Cardiac sympathetic denervation and mental health. Khalsa SS, Clausen AN, Shahabi L, Sorg J, Gonzalez SE, Naliboff B, Shivkumar K, Ajijola OA Autonomic neuroscience : basic & clinical 33631539 Auton Neurosci 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33631539
RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity. Bardsley EN, Davis H, Ajijola OA, Buckler KJ, Ardell JL, Shivkumar K, Paterson DJ Scientific reports 29872217 Sci Rep 2018 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/29872217
Single-cell transcriptomic profiling of satellite glial cells in stellate ganglia reveals developmental and functional axial dynamics. van Weperen VYH, Littman RJ, Arneson DV, Contreras J, Yang X, Ajijola OA Glia 33432730 Glia 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33432730
3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis. Colbert CM, Shao J, Hollowed JJ, Currier JW, Ajijola OA, Fishbein GA, Duarte-Vogel SM, Dharmakumar R, Hu P, Nguyen KL Journal of cardiovascular translational research 32394352 J Cardiovasc Transl Res 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32394352
Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains. Davis H, Bardsley EN, Paterson DJ Scientific data 29944142 Sci Data 2018 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/29944142
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review. Meng L, Tseng CH, Shivkumar K, Ajijola O JACC. Clinical electrophysiology 29270467 JACC Clin Electrophysiol 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/29270467
Neuromodulation Approaches for Cardiac Arrhythmias: Recent Advances. Dusi V, Zhu C, Ajijola OA Current cardiology reports 30887264 Curr Cardiol Rep 2019 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/30887264
A novel metric linking stellate ganglion neuronal population dynamics to cardiopulmonary physiology. Sudarshan KB, Hori Y, Swid MA, Karavos AC, Wooten C, Armour JA, Kember G, Ajijola OA American journal of physiology. Heart and circulatory physiology 34213390 Am J Physiol Heart Circ Physiol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/34213390
Cardiac afferent signaling partially underlies premature ventricular contraction-induced cardiomyopathy. Hori Y, Temma T, Wooten C, Sobowale C, Chan C, Swid M, Ajijola OA Heart rhythm 33845214 Heart Rhythm 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33845214
Tiered sympathetic control of cardiac function revealed by viral tracing and single cell transcriptome profiling. Sharma S, Littman R, Tompkins JD, Arneson D, Contreras J, Dajani AH, Ang K, Tsanhani A, Sun X, Jay PY, Herzog H, Yang X, Ajijola OA eLife 37162194 Elife 2023 May 10 https://www.ncbi.nlm.nih.gov/pubmed/37162194
Circulating Neuropeptide Y as a Biomarker for Neuromodulation in Atrial Fibrillation. Stavrakis S, Morris L, Takashima AD, Elkholey K, Van Wagoner DR, Ajijola OA JACC. Clinical electrophysiology 33213819 JACC Clin Electrophysiol 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33213819
Prognostic impact of atrial rhythm and dimension in patients with structural heart disease undergoing cardiac sympathetic denervation for ventricular arrhythmias. Dusi V, Sorg JM, Gornbein J, Gima J, Yanagawa J, Lee JM, Vecerek N, Vaseghi M, Bradfield JS, De Ferrari GM, Shivkumar K, Ajijola OA Heart rhythm 31837474 Heart Rhythm 2020 May https://www.ncbi.nlm.nih.gov/pubmed/31837474
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Chronic Kidney Disease: A Nerve-Racking Situation for the Heart. Ajijola OA Circulation research 35209720 Circ Res 2022 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/35209720
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Motif-Raptor: a cell type-specific and transcription factor centric approach for post-GWAS prioritization of causal regulators. Yao Q, Ferragina P, Reshef Y, Lettre G, Bauer DE, Pinello L Bioinformatics (Oxford, England) 33532840 Bioinformatics 2021 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/33532840
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities. Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK Nature biotechnology 30059493 Nat Biotechnol 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30059493
CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis. Schoonenberg VAC, Cole MA, Yao Q, Macias-Treviño C, Sher F, Schupp PG, Canver MC, Maeda T, Pinello L, Bauer DE Genome biology 30340514 Genome Biol 2018 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/30340514
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Spatial presentation of biological molecules to cells by localized diffusive transfer. Regier MC, Olszewski E, Carter CC, Aitchison JD, Kaushansky A, Davis J, Berthier E, Beebe DJ, Stevens KR Lab on a chip 31111131 Lab Chip 2019 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/31111131
User-defined morphogen patterning for directing human cell fate stratification. Regier MC, Tokar JJ, Warrick JW, Pabon L, Berthier E, Beebe DJ, Stevens KR Scientific reports 31015521 Sci Rep 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/31015521
Human Organ-Specific Endothelial Cell Heterogeneity. Marcu R, Choi YJ, Xue J, Fortin CL, Wang Y, Nagao RJ, Xu J, MacDonald JW, Bammler TK, Murry CE, Muczynski K, Stevens KR, Himmelfarb J, Schwartz SM, Zheng Y iScience 30240741 iScience 2018 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/30240741
Photopatterned biomolecule immobilization to guide three-dimensional cell fate in natural protein-based hydrogels. Batalov I, Stevens KR, DeForest CA Proceedings of the National Academy of Sciences of the United States of America 33468675 Proc Natl Acad Sci U S A 2021 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/33468675
Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates. Kinstlinger IS, Saxton SH, Calderon GA, Ruiz KV, Yalacki DR, Deme PR, Rosenkrantz JE, Louis-Rosenberg JD, Johansson F, Janson KD, Sazer DW, Panchavati SS, Bissig KD, Stevens KR, Miller JS Nature biomedical engineering 32601395 Nat Biomed Eng 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32601395
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Thermofluidic heat exchangers for actuation of transcription in artificial tissues. Corbett DC, Fabyan WB, Grigoryan B, O'Connor CE, Johansson F, Batalov I, Regier MC, DeForest CA, Miller JS, Stevens KR Science advances 32998880 Sci Adv 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32998880
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals. Bugg D, Bretherton R, Kim P, Olszewski E, Nagle A, Schumacher AE, Chu N, Gunaje J, DeForest CA, Stevens K, Kim DH, Davis J Circulation research 32883176 Circ Res 2020 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/32883176
Human Pluripotent Stem Cell-Derived Engineered Tissues: Clinical Considerations. Stevens KR, Murry CE Cell stem cell 29499147 Cell Stem Cell 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29499147
Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Grigoryan B, Paulsen SJ, Corbett DC, Sazer DW, Fortin CL, Zaita AJ, Greenfield PT, Calafat NJ, Gounley JP, Ta AH, Johansson F, Randles A, Rosenkrantz JE, Louis-Rosenberg JD, Galie PA, Stevens KR, Miller JS Science (New York, N.Y.) 31048486 Science 2019 May 3 https://www.ncbi.nlm.nih.gov/pubmed/31048486
A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives. El-Nachef D, Shi K, Beussman KM, Martinez R, Regier MC, Everett GW, Murry CE, Stevens KR, Young JE, Sniadecki NJ, Davis J Stem cell reports 32619493 Stem Cell Reports 2020 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/32619493
Engineering Heart Morphogenesis. Mandrycky CJ, Williams NP, Batalov I, El-Nachef D, de Bakker BS, Davis J, Kim DH, DeForest CA, Zheng Y, Stevens KR, Sniadecki NJ Trends in biotechnology 32673587 Trends Biotechnol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32673587
Embryo-scale, single-cell spatial transcriptomics. Srivatsan SR, Regier MC, Barkan E, Franks JM, Packer JS, Grosjean P, Duran M, Saxton S, Ladd JJ, Spielmann M, Lois C, Lampe PD, Shendure J, Stevens KR, Trapnell C Science (New York, N.Y.) 34210887 Science 2021 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/34210887
A FRESH Take on Resolution in 3D Bioprinting. Corbett DC, Olszewski E, Stevens K Trends in biotechnology 31623960 Trends Biotechnol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31623960
Guided vascularization in the rat heart leads to transient vessel patterning. Brady EL, Kirby MA, Olszewski E, Grosjean P, Johansson F, Davis J, Wang RK, Stevens KR APL bioengineering 32161835 APL Bioeng 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32161835
Engineered tissue vascularization and engraftment depends on host model. Brady EL, Prado O, Johansson F, Mitchell SN, Martinson AM, Karbassi E, Reinecke H, Murry CE, Davis J, Stevens KR Scientific reports 36737618 Sci Rep 2023 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/36737618
Assessing the Physiological Relevance of Cough Simulators for Respiratory Droplet Dispersion. Patel SH, Yim W, Garg AK, Shah SH, Jokerst JV, Chao DL Journal of clinical medicine 32957639 J Clin Med 2020 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/32957639
Multispectral Nanoparticle Tracking Analysis for the Real-Time and Label-Free Characterization of Amyloid-β Self-Assembly In Vitro. Moore C, Wing R, Pham T, Jokerst JV Analytical chemistry 32786456 Anal Chem 2020 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/32786456
Smart-Dust-Nanorice for Enhancement of Endogenous Raman Signal, Contrast in Photoacoustic Imaging, and T2-Shortening in Magnetic Resonance Imaging. Pohling C, Campbell JL, Larson TA, Van de Sompel D, Levi J, Bachmann MH, Bohndiek SE, Jokerst JV, Gambhir SS Small (Weinheim an der Bergstrasse, Germany) 29635739 Small 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29635739
Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements. Lin CY, Chen F, Hariri A, Chen CJ, Wilder-Smith P, Takesh T, Jokerst JV Journal of dental research 28880116 J Dent Res 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28880116
Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles. Kang J, Kim D, Wang J, Han Y, Zuidema JM, Hariri A, Park JH, Jokerst JV, Sailor MJ Advanced materials (Deerfield Beach, Fla.) 29782671 Adv Mater 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29782671
A Mechanistic Investigation of Methylene Blue and Heparin Interactions and Their Photoacoustic Enhancement. Wang J, Jeevarathinam AS, Humphries K, Jhunjhunwala A, Chen F, Hariri A, Miller BR 3rd, Jokerst JV Bioconjugate chemistry 30281976 Bioconjug Chem 2018 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/30281976
Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization. Wang J, Lin CY, Moore C, Jhunjhunwala A, Jokerst JV Langmuir : the ACS journal of surfaces and colloids 29232146 Langmuir 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29232146
A cellulose-based photoacoustic sensor to measure heparin concentration and activity in human blood samples. Jeevarathinam AS, Pai N, Huang K, Hariri A, Wang J, Bai Y, Wang L, Hancock T, Keys S, Penny W, Jokerst JV Biosensors & bioelectronics 30602265 Biosens Bioelectron 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30602265
Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells. Lemaster JE, Chen F, Kim T, Hariri A, Jokerst JV ACS applied nano materials 33860154 ACS Appl Nano Mater 2018 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/33860154
A Wearable Colorimetric Dosimeter to Monitor Sunlight Exposure. Wang J, Jeevarathinam AS, Jhunjhunwala A, Ren H, Lemaster J, Luo Y, Fenning DP, Fullerton EE, Jokerst JV Advanced materials technologies 33928184 Adv Mater Technol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/33928184
Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window. Yim W, Borum RM, Zhou J, Mantri Y, Wu Z, Zhou J, Jin Z, Creyer M, Jokerst JV Nanotheranostics 34976582 Nanotheranostics 2022 https://www.ncbi.nlm.nih.gov/pubmed/34976582
A Photoacoustic-Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis. Moore C, Cheng Y, Tjokro N, Zhang B, Kerr M, Hayati M, Chang KCJ, Shah N, Chen C, Jokerst JV Angewandte Chemie (International ed. in English) 35583940 Angew Chem Int Ed Engl 2022 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/35583940
A fiber optic photoacoustic sensor for real-time heparin monitoring. Zhou J, Yim W, Zhou J, Jin Z, Xu M, Mantri Y, He T, Cheng Y, Fu L, Wu Z, Hancock T, Penny W, Jokerst JV Biosensors & bioelectronics 34653712 Biosens Bioelectron 2022 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/34653712
Enhanced Photoacoustic Detection of Heparin in Whole Blood via Melanin Nanocapsules Carrying Molecular Agents. Yim W, Takemura K, Zhou J, Zhou J, Jin Z, Borum RM, Xu M, Cheng Y, He T, Penny W, Miller BR 3rd, Jokerst JV ACS nano 34962765 ACS Nano 2022 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/34962765
Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels Using Metallic Nano-Islands on Graphene. Dhong C, Edmunds SJ, Ramírez J, Kayser LV, Chen F, Jokerst JV, Lipomi DJ Nano letters 30024767 Nano Lett 2018 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/30024767
Photoacoustic imaging for monitoring periodontal health: A first human study. Moore C, Bai Y, Hariri A, Sanchez JB, Lin CY, Koka S, Sedghizadeh P, Chen C, Jokerst JV Photoacoustics 30450281 Photoacoustics 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30450281
Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue-Poly(l-lysine) Nanocomplexes. Kim T, Lemaster JE, Chen F, Li J, Jokerst JV ACS nano 28759195 ACS Nano 2017 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/28759195
Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging. Moore C, Chen F, Wang J, Jokerst JV Advanced drug delivery reviews 31295522 Adv Drug Deliv Rev 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/31295522
Noninvasive staging of pressure ulcers using photoacoustic imaging. Hariri A, Chen F, Moore C, Jokerst JV Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 31301258 Wound Repair Regen 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31301258
Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents. Xie Y, Wang J, Wang J, Hu Z, Hariri A, Tu N, Krug KA, Burkart MD, Gianneschi NC, Jokerst JV, Rinehart JD Journal of materials chemistry. B 31389967 J Mater Chem B 2019 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/31389967
Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging. Moore C, Jokerst JV Theranostics 31037123 Theranostics 2019 https://www.ncbi.nlm.nih.gov/pubmed/31037123
Stem Cell Tracking with Nanoparticle-Based Ultrasound Contrast Agents. Chen F, Jokerst JV Methods in molecular biology (Clifton, N.J.) 32112386 Methods Mol Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32112386
Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions. Lemaster JE, Jeevarathinam AS, Kumar A, Chandrasekar B, Chen F, Jokerst JV ACS applied bio materials 31930189 ACS Appl Bio Mater 2019 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/31930189
Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo. Jeevarathinam AS, Lemaster JE, Chen F, Zhao E, Jokerst JV Angewandte Chemie (International ed. in English) 31840357 Angew Chem Int Ed Engl 2020 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/31840357
Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity. Moore C, Borum RM, Mantri Y, Xu M, Fajtová P, O'Donoghue AJ, Jokerst JV ACS sensors 34038103 ACS Sens 2021 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/34038103
Gadolinium Doping Enhances the Photoacoustic Signal of Synthetic Melanin Nanoparticles: A Dual Modality Contrast Agent for Stem Cell Imaging. Lemaster JE, Wang Z, Hariri A, Chen F, Hu Z, Huang Y, Barback CV, Cochran R, Gianneschi NC, Jokerst JV Chemistry of materials : a publication of the American Chemical Society 33859455 Chem Mater 2019 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/33859455
Gold Nanorod-Melanin Hybrids for Enhanced and Prolonged Photoacoustic Imaging in the Near-Infrared-II Window. Yim W, Zhou J, Mantri Y, Creyer MN, Moore CA, Jokerst JV ACS applied materials & interfaces 33761255 ACS Appl Mater Interfaces 2021 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/33761255
Motion-compensated noninvasive periodontal health monitoring using handheld and motor-based photoacoustic-ultrasound imaging systems. Mozaffarzadeh M, Moore C, Golmoghani EB, Mantri Y, Hariri A, Jorns A, Fu L, Verweij MD, Orooji M, de Jong N, Jokerst JV Biomedical optics express 33796371 Biomed Opt Express 2021 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/33796371
Silicon Carbide Nanoparticles as a Photoacoustic and Photoluminescent Dual-Imaging Contrast Agent for Long-Term Cell Tracking. Chen F, Zhao ER, Hu T, Shi Y, Sirbuly DJ, Jokerst JV Nanoscale advances 33313479 Nanoscale Adv 2019 https://www.ncbi.nlm.nih.gov/pubmed/33313479
Increasing the Efficacy of Stem Cell Therapy via Triple-Function Inorganic Nanoparticles. Chen F, Zhao ER, Hableel G, Hu T, Kim T, Li J, Gonzalez-Pech NI, Cheng DJ, Lemaster JE, Xie Y, Grassian VH, Sen GL, Jokerst JV ACS nano 31188564 ACS Nano 2019 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/31188564
Photoacoustic imaging with fiber optic technology: A review. Zhou J, Jokerst JV Photoacoustics 33163358 Photoacoustics 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33163358
Hybridizing clinical translatability with enzyme-free DNA signal amplifiers: recent advances in nucleic acid detection and imaging. Borum RM , Jokerst JV Biomaterials science 32734995 Biomater Sci 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/32734995
Assessment of Respiratory Droplet Transmission During the Ophthalmic Slit-Lamp Exam: A Particle Tracking Analysis. Shah SH, Garg AK, Patel S, Yim W, Jokerst JV, Chao DL American journal of ophthalmology 32980331 Am J Ophthalmol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/32980331
Supramolecular Loading of DNA Hydrogels with Dye-Drug Conjugates for Real-Time Photoacoustic Monitoring of Chemotherapy. Borum RM, Moore C, Mantri Y, Xu M, Jokerst JV Advanced science (Weinheim, Baden-Wurttemberg, Germany) 36403233 Adv Sci (Weinh) 2022 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/36403233
Exosome-like silica nanoparticles: a novel ultrasound contrast agent for stem cell imaging. Chen F, Ma M, Wang J, Wang F, Chern SX, Zhao ER, Jhunjhunwala A, Darmadi S, Chen H, Jokerst JV Nanoscale 27924340 Nanoscale 2017 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/27924340
The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging. Hariri A, Lemaster J, Wang J, Jeevarathinam AS, Chao DL, Jokerst JV Photoacoustics 29234601 Photoacoustics 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29234601
The development and characterization of a novel yet simple 3D printed tool to facilitate phantom imaging of photoacoustic contrast agents. Arconada-Alvarez SJ, Lemaster JE, Wang J, Jokerst JV Photoacoustics 28239554 Photoacoustics 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28239554
A Nanoscale Tool for Photoacoustic-Based Measurements of Clotting Time and Therapeutic Drug Monitoring of Heparin. Wang J, Chen F, Arconada-Alvarez SJ, Hartanto J, Yap LP, Park R, Wang F, Vorobyova I, Dagliyan G, Conti PS, Jokerst JV Nano letters 27668964 Nano Lett 2016 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/27668964
KN95 and N95 Respirators Retain Filtration Efficiency despite a Loss of Dipole Charge during Decontamination. Yim W, Cheng D, Patel SH, Kou R, Meng YS, Jokerst JV ACS applied materials & interfaces 33253527 ACS Appl Mater Interfaces 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33253527
Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging. Wang J, Hsu SW, Gonzalez-Pech N, Jhunjhunwala A, Chen F, Hariri A, Grassian V, Tao A, Jokerst JV Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems 32863594 Part Part Syst Charact 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/32863594
Cellular toxicity of silicon carbide nanomaterials as a function of morphology. Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV Biomaterials 29980075 Biomaterials 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29980075
Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. Hariri A, Zhao E, Jeevarathinam AS, Lemaster J, Zhang J, Jokerst JV Scientific reports 31388020 Sci Rep 2019 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/31388020
Dictionary learning technique enhances signal in LED-based photoacoustic imaging. Farnia P, Najafzadeh E, Hariri A, Lavasani SN, Makkiabadi B, Ahmadian A, Jokerst JV Biomedical optics express 32499941 Biomed Opt Express 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32499941
Deep learning improves contrast in low-fluence photoacoustic imaging. Hariri A, Alipour K, Mantri Y, Schulze JP, Jokerst JV Biomedical optics express 32637260 Biomed Opt Express 2020 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/32637260
A Photoacoustic Contrast Agent for miR-21 via NIR Fluorescent Hybridization Chain Reaction. Borum RM, Moore C, Chan SK, Steinmetz NF, Jokerst JV Bioconjugate chemistry 34406744 Bioconjug Chem 2022 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/34406744
Peptide-Induced Fractal Assembly of Silver Nanoparticles for Visual Detection of Disease Biomarkers. Retout M, Mantri Y, Jin Z, Zhou J, Noël G, Donovan B, Yim W, Jokerst JV ACS nano 35377141 ACS Nano 2022 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/35377141
Organosilica Nanoparticles with an Intrinsic Secondary Amine: An Efficient and Reusable Adsorbent for Dyes. Chen F, Zhao E, Kim T, Wang J, Hableel G, Reardon PJT, Ananthakrishna SJ, Wang T, Arconada-Alvarez S, Knowles JC, Jokerst JV ACS applied materials & interfaces 28422482 ACS Appl Mater Interfaces 2017 May 10 https://www.ncbi.nlm.nih.gov/pubmed/28422482
Versatile Polymer Nanocapsules via Redox Competition. Zhou J, Xu M, Jin Z, Borum RM, Avakyan N, Cheng Y, Yim W, He T, Zhou J, Wu Z, Mantri Y, Jokerst JV Angewandte Chemie (International ed. in English) 34580967 Angew Chem Int Ed Engl 2021 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/34580967
The in vivo fate of tobacco mosaic virus nanoparticle theranostic agents modified by the addition of a polydopamine coat. Nkanga CI, Chung YH, Shukla S, Zhou J, Jokerst JV, Steinmetz NF Biomaterials science 34591046 Biomater Sci 2021 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/34591046
Engineering Plasmonic Nanoparticles for Enhanced Photoacoustic Imaging. Mantri Y, Jokerst JV ACS nano 32806027 ACS Nano 2020 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/32806027
Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging. Mantri Y, Davidi B, Lemaster JE, Hariri A, Jokerst JV Nanoscale 32396928 Nanoscale 2020 May 21 https://www.ncbi.nlm.nih.gov/pubmed/32396928
Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions. Zhou J, Penna M, Lin Z, Han Y, Lafleur RPM, Qu Y, Richardson JJ, Yarovsky I, Jokerst JV, Caruso F Angewandte Chemie (International ed. in English) 34258845 Angew Chem Int Ed Engl 2021 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/34258845
Stereoselective Growth of Small Molecule Patches on Nanoparticles. Zhou J, Creyer MN, Chen A, Yim W, Lafleur RPM, He T, Lin Z, Xu M, Abbasi P, Wu J, Pascal TA, Caruso F, Jokerst JV Journal of the American Chemical Society 34270250 J Am Chem Soc 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34270250
Multifunctional nanomedicine with silica: Role of silica in nanoparticles for theranostic, imaging, and drug monitoring. Chen F, Hableel G, Zhao ER, Jokerst JV Journal of colloid and interface science 29510868 J Colloid Interface Sci 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/29510868
A Gold/Silver Hybrid Nanoparticle for Treatment and Photoacoustic Imaging of Bacterial Infection. Kim T, Zhang Q, Li J, Zhang L, Jokerst JV ACS nano 29746090 ACS Nano 2018 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/29746090
Simultaneous Enhancement of Photoluminescence, MRI Relaxivity, and CT Contrast by Tuning the Interfacial Layer of Lanthanide Heteroepitaxial Nanoparticles. He S, Johnson NJJ, Nguyen Huu VA, Cory E, Huang Y, Sah RL, Jokerst JV, Almutairi A Nano letters 28657755 Nano Lett 2017 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/28657755
Gold nanoparticles to enhance ophthalmic imaging. Chen F , Si P , de la Zerda A , Jokerst JV , Myung D Biomaterials science 33057463 Biomater Sci 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/33057463
In vivo photoacoustic imaging of chorioretinal oxygen gradients. Hariri A, Wang J, Kim Y, Jhunjhunwala A, Chao DL, Jokerst JV Journal of biomedical optics 29524321 J Biomed Opt 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29524321
Synchronization of RF Data in Ultrasound Open Platforms (UOPs) for High-Accuracy and High-Resolution Photoacoustic Tomography Using the "Scissors" Programming Method. Fu L, Jin Z, Qi B, Yim W, Wu Z, He T, Jokerst JV IEEE transactions on ultrasonics, ferroelectrics, and frequency control 35377843 IEEE Trans Ultrason Ferroelectr Freq Control 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35377843
Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine. Wu D , Zhou J , Creyer MN , Yim W , Chen Z , Messersmith PB , Jokerst JV Chemical Society reviews 33595004 Chem Soc Rev 2021 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/33595004
A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity. Retout M, Amer L, Yim W, Creyer MN, Lam B, Trujillo DF, Potempa J, O'Donoghue AJ, Chen C, Jokerst JV ACS nano 37602819 ACS Nano 2023 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/37602819
Polyphenol-stabilized coacervates for enzyme-triggered drug delivery. Yim W, Jin Z, Chang YC, Brambila C, Creyer MN, Ling C, He T, Li Y, Retout M, Penny WF, Zhou J, Jokerst JV Nature communications 39181884 Nat Commun 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39181884
Activatable Photoacoustic Probe for Imaging Infection: Gold Nanorod Dissociation In Vivo Reports Bacterial Protease Activity. Retout M, Lepeintre V, Amer L, Yim W, Jokerst JV ACS nano 40116426 ACS Nano 2025 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/40116426
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT Communications biology 30271928 Commun Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30271928
Cryo-electron tomography with mixed-scale dense neural networks reveals key steps in deployment of Toxoplasma invasion machinery. Segev-Zarko LA, Dahlberg PD, Sun SY, Pelt DM, Kim CY, Egan ES, Sethian JA, Chiu W, Boothroyd JC PNAS nexus 36329726 PNAS Nexus 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36329726
Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum. Sun SY, Segev-Zarko L-a, Pintilie GD, Kim CY, Staggers SR, Schmid MF, Egan ES, Chiu W, Boothroyd JC mBio 38456679 mBio 2024 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/38456679
Beyond Hemoglobin: Screening for Malaria Host Factors. Egan ES Trends in genetics : TIG 29249333 Trends Genet 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29249333
Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites. Shakya B, Patel SD, Tani Y, Egan ES eLife 34028351 Elife 2021 May 24 https://www.ncbi.nlm.nih.gov/pubmed/34028351
Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy. Ebel ER, Uricchio LH, Petrov DA, Egan ES Trends in parasitology 35065882 Trends Parasitol 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35065882
A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans. Nguetse CN, Purington N, Ebel ER, Shakya B, Tetard M, Kremsner PG, Velavan TP, Egan ES Proceedings of the National Academy of Sciences of the United States of America 32265284 Proc Natl Acad Sci U S A 2020 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/32265284
Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion. Baro B, Kim CY, Lin C, Kongsomboonvech AK, Tetard M, Peterson NA, Salinas ND, Tolia NH, Egan ES Blood 37832027 Blood 2023 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/37832027
Uncovering a Cryptic Site of Malaria Pathogenesis: Models to Study Interactions Between Plasmodium and the Bone Marrow. Feldman TP, Egan ES Frontiers in cellular and infection microbiology 35719356 Front Cell Infect Microbiol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35719356
Understanding and repurposing CRISPR-mediated alternative splicing. Smith JL, Mou H, Xue W Genome biology 30400804 Genome Biol 2018 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/30400804
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG Nature chemical biology 29377001 Nat Chem Biol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29377001
Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. Li B, Manan RS, Liang SQ, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D Nature biotechnology 36997680 Nat Biotechnol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/36997680
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, Watts JK, Xue W, Sontheimer EJ Nature biotechnology 37709915 Nat Biotechnol 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/37709915
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. Liang SQ, Liu P, Ponnienselvan K, Suresh S, Chen Z, Kramme C, Chatterjee P, Zhu LJ, Sontheimer EJ, Xue W, Wolfe SA Nature methods 37156841 Nat Methods 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37156841
Template-jumping prime editing enables large insertion and exon rewriting in vivo. Zheng C, Liu B, Dong X, Gaston N, Sontheimer EJ, Xue W Nature communications 37291100 Nat Commun 2023 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/37291100
AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys. Liang SQ, Navia AW, Ramseier M, Zhou X, Martinez M, Lee C, Zhou C, Wu J, Xie J, Su Q, Wang D, Flotte TR, Anderson DG, Tarantal AF, Shalek AK, Gao G, Xue W Human gene therapy 38767512 Hum Gene Ther 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38767512
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Pérez JA, Sontheimer EJ Molecular cell 30581144 Mol Cell 2019 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/30581144
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D Jr, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W Gastroenterology 27956228 Gastroenterology 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/27956228
Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins. Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ RNA (New York, N.Y.) 31439808 RNA 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31439808
Deletion and replacement of long genomic sequences using prime editing. Jiang T, Zhang XO, Weng Z, Xue W Nature biotechnology 34650270 Nat Biotechnol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34650270
Adenine base editing in an adult mouse model of tyrosinaemia. Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W Nature biomedical engineering 31740768 Nat Biomed Eng 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31740768
CRISPR-Cas-related technologies in basic and translational liver research. Song CQ, Xue W Nature reviews. Gastroenterology & hepatology 29443117 Nat Rev Gastroenterol Hepatol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29443117
Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang T, Sánchez-Rivera FJ, Soto-Feliciano YM, Yang Q, Song CQ, Bhuatkar A, Haynes CM, Hemann MT, Xue W Hepatology (Baltimore, Md.) 33336367 Hepatology 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33336367
YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells. Smith JL, Rodríguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Weng Z, Sontheimer EJ, Xue W Hepatology (Baltimore, Md.) 32452550 Hepatology 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/32452550
All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ Genome biology 30231914 Genome Biol 2018 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/30231914
Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases. Wu SS, Li QC, Yin CQ, Xue W, Song CQ Theranostics 32292501 Theranostics 2020 https://www.ncbi.nlm.nih.gov/pubmed/32292501
Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes. Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W Hepatology (Baltimore, Md.) 31188495 Hepatology 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31188495
AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Liang SQ, Walkey CJ, Martinez AE, Su Q, Dickinson ME, Wang D, Lagor WR, Heaney JD, Gao G, Xue W Molecular therapy : the journal of the American Society of Gene Therapy 34695545 Mol Ther 2022 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/34695545
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Liang SQ, Liu P, Smith JL, Mintzer E, Maitland S, Dong X, Yang Q, Lee J, Haynes CM, Zhu LJ, Watts JK, Sontheimer EJ, Wolfe SA, Xue W Nature communications 35064134 Nat Commun 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/35064134
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Liu P, Liang SQ, Zheng C, Mintzer E, Zhao YG, Ponnienselvan K, Mir A, Sontheimer EJ, Gao G, Flotte TR, Wolfe SA, Xue W Nature communications 33837189 Nat Commun 2021 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/33837189
A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver. Zheng C, Liang SQ, Liu B, Liu P, Kwan SY, Wolfe SA, Xue W Molecular therapy : the journal of the American Society of Gene Therapy 34998953 Mol Ther 2022 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/34998953
Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes. Rodríguez TC, Kwan SY, Smith JL, Dadafarin S, Wu CH, Sontheimer EJ, Xue W Hepatology (Baltimore, Md.) 35932276 Hepatology 2023 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/35932276
CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W Genome biology 28615073 Genome Biol 2017 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/28615073
Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Mou H, Moore J, Malonia SK, Li Y, Ozata DM, Hough S, Song CQ, Smith JL, Fischer A, Weng Z, Green MR, Xue W Proceedings of the National Academy of Sciences of the United States of America 28320962 Proc Natl Acad Sci U S A 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28320962
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ Nature communications 34725353 Nat Commun 2021 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/34725353
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G Nature biotechnology 30102296 Nat Biotechnol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30102296
The temporal landscape of recursive splicing during Pol II transcription elongation in human cells. Zhang XO, Fu Y, Mou H, Xue W, Weng Z PLoS genetics 30148885 PLoS Genet 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30148885
In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency. Song CQ, Wang D, Jiang T, O'Connor K, Tang Q, Cai L, Li X, Weng Z, Yin H, Gao G, Mueller C, Flotte TR, Xue W Human gene therapy 29597895 Hum Gene Ther 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29597895
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG Nature biotechnology 29131148 Nat Biotechnol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29131148
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, Liu DR, Xue W Nature communications 32332735 Nat Commun 2020 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/32332735
CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling. Mou H, Ozata DM, Smith JL, Sheel A, Kwan SY, Hough S, Kucukural A, Kennedy Z, Cao Y, Xue W Genome medicine 30987660 Genome Med 2019 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/30987660
A split prime editor with untethered reverse transcriptase and circular RNA template. Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodríguez TC, Liang SQ, Xue W, Sontheimer EJ Nature biotechnology 35379962 Nat Biotechnol 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35379962
Human monocyte transcriptional profiling identifies IL-18 receptor accessory protein and lactoferrin as novel immune targets in hypertension. Alexander MR, Norlander AE, Elijovich F, Atreya RV, Gaye A, Gnecco JS, Laffer CL, Galindo CL, Madhur MS British journal of pharmacology 29774543 Br J Pharmacol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/29774543
Status of Early-Career Academic Cardiology: A Global Perspective. Tong CW, Madhur MS, Rzeszut AK, Abdalla M, Abudayyeh I, Alexanderson E, Buber J, Feldman DN, Gopinathannair R, Hira RS, Kates AM, Kessler T, Leung S, Raj SR, Spatz ES, Turner MB, Valente AM, West K, Sivaram CA, Hill JA, Mann DL, Freeman AM Journal of the American College of Cardiology 29073958 J Am Coll Cardiol 2017 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/29073958
Adaptive immune cells in calcific aortic valve disease. Raddatz MA, Madhur MS, Merryman WD American journal of physiology. Heart and circulatory physiology 31050556 Am J Physiol Heart Circ Physiol 2019 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/31050556
Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice. Chen Y, Dale BL, Alexander MR, Xiao L, Ao M, Pandey AK, Smart CD, Davis GK, Madhur MS Cardiovascular research 32609312 Cardiovasc Res 2021 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/32609312
LNK deficiency promotes acute aortic dissection and rupture. Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS JCI insight 30333305 JCI Insight 2018 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/30333305
Evidence for a Causal Role of the SH2B3-β(2)M Axis in Blood Pressure Regulation. Keefe JA, Hwang SJ, Huan T, Mendelson M, Yao C, Courchesne P, Saleh MA, Madhur MS, Levy D Hypertension (Dallas, Tex. : 1979) 30624993 Hypertension 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30624993
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage. Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS Circulation research 36169218 Circ Res 2022 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/36169218
Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic? Madhur MS, Elijovich F, Alexander MR, Pitzer A, Ishimwe J, Van Beusecum JP, Patrick DM, Smart CD, Kleyman TR, Kingery J, Peck RN, Laffer CL, Kirabo A Circulation research 33793336 Circ Res 2021 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/33793336
Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species. Alexander MR, Schoeder CT, Brown JA, Smart CD, Moth C, Wikswo JP, Capra JA, Meiler J, Chen W, Madhur MS FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33015868 FASEB J 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33015868
Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction. Dale BL, Pandey AK, Chen Y, Smart CD, Laroumanie F, Ao M, Xiao L, Dikalova AE, Dikalov SI, Elijovich F, Foss JD, Barbaro NR, Van Beusecum JP, Deger SM, Alsouqi A, Itani HA, Norlander AE, Alexander MR, Zhao S, Ikizler TA, Algood HMS, Madhur MS JCI insight 31013256 JCI Insight 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/31013256
From Rags to Riches: Moving Beyond RAG1 in Studies of Hypertension. Madhur MS, Kirabo A, Guzik TJ, Harrison DG Hypertension (Dallas, Tex. : 1979) 32078385 Hypertension 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32078385
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure. Smart CD, Fehrenbach DJ, Wassenaar JW, Agrawal V, Fortune NL, Dixon DD, Cottam MA, Hasty AH, Hemnes AR, Doran AC, Gupta DK, Madhur MS Cardiovascular research 37314125 Cardiovasc Res 2023 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/37314125
A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Laroumanie F, Du L, Harrison DG, Madhur MS JCI insight 28679951 JCI Insight 2017 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/28679951
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K(+)] during K(+)-deficient diet. McFarlin BE, Chen Y, Priver TS, Ralph DL, Mercado A, Gamba G, Madhur MS, McDonough AA American journal of physiology. Cell physiology 32845718 Am J Physiol Cell Physiol 2020 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/32845718
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, Berry C, Touyz RM, Kreutz R, Wang DW, Bhella D, Sagliocco O, Crea F, Thomson EC, McInnes IB Cardiovascular research 32352535 Cardiovasc Res 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32352535
Interleukin 17A: Key Player in the Pathogenesis of Hypertension and a Potential Therapeutic Target. Davis GK, Fehrenbach DJ, Madhur MS Current hypertension reports 33666761 Curr Hypertens Rep 2021 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/33666761
The immunology of hypertension. Norlander AE, Madhur MS, Harrison DG The Journal of experimental medicine 29247045 J Exp Med 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29247045
Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease. Gonzalez AL, Dungan MM, Smart CD, Madhur MS, Doran AC Antioxidants & redox signaling 37125445 Antioxid Redox Signal 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37125445
Targeting IL-33/ST2 Signaling Alters Cardiac Structure and Function in Hypertensive Heart Disease. Wassenaar JW, Smart CD, Fehrenbach DJ, Agrawal V, Dungan MM, Fortune NL, Zhong L, Hemnes AR, Peebles RS Jr, Miller FJ Jr, Doran AC, Madhur MS JACC. Basic to translational science 39958476 JACC Basic Transl Sci 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39958476
Targeted Delivery of Cell Softening Micelles to Schlemm's Canal Endothelial Cells for Treatment of Glaucoma. Stack T, Vincent M, Vahabikashi A, Li G, Perkumas KM, Stamer WD, Johnson M, Scott E Small (Weinheim an der Bergstrasse, Germany) 33015961 Small 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33015961
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation. Allen S, Vincent M, Scott E Journal of visualized experiments : JoVE 30148497 J Vis Exp 2018 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/30148497
Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis. Yi S, Allen SD, Liu YG, Ouyang BZ, Li X, Augsornworawat P, Thorp EB, Scott EA ACS nano 27935698 ACS Nano 2016 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/27935698
Just add water: hydratable, morphologically diverse nanocarrier powders for targeted delivery. Bobbala S, Vincent MP, Scott EA Nanoscale 34160529 Nanoscale 2021 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/34160529
Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA ACS applied materials & interfaces 34232612 ACS Appl Mater Interfaces 2021 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/34232612
Enhancing subcutaneous injection and target tissue accumulation of nanoparticles via co-administration with macropinocytosis inhibitory nanoparticles (MiNP). Stack T, Liu Y, Frey M, Bobbala S, Vincent M, Scott E Nanoscale horizons 33884386 Nanoscale Horiz 2021 May 1 https://www.ncbi.nlm.nih.gov/pubmed/33884386
On the advancement of polymeric bicontinuous nanospheres toward biomedical applications. Allen SD, Bobbala S, Karabin NB, Scott EA Nanoscale horizons 32254084 Nanoscale Horiz 2019 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/32254084
Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity. Bobbala S, Allen SD, Yi S, Vincent M, Frey M, Karabin NB, Scott EA Nanoscale 32090217 Nanoscale 2020 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/32090217
Efficacy of benznidazole delivery during Chagas disease nanotherapy is dependent on the nanocarrier morphology. Scariot DB, Staneviciute A, Machado RRB, Yuk SA, Liu YG, Sharma S, Almunif S, Arona Mbaye EH, Nakamura CV, Engman DM, Scott EA Biomaterials 40318604 Biomaterials 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/40318604
Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes. Du F, Bobbala S, Yi S, Scott EA Journal of controlled release : official journal of the Controlled Release Society 29601932 J Control Release 2018 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/29601932
Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection. Li X, Yi S, Scariot DB, Martinez SJ, Falk BA, Olson CL, Romano PS, Scott EA, Engman DM JCI insight 33986194 JCI Insight 2021 May 10 https://www.ncbi.nlm.nih.gov/pubmed/33986194
Surface engineered polymersomes for enhanced modulation of dendritic cells during cardiovascular immunotherapy. Yi S, Zhang X, Sangji H, Liu Y, Allen SD, Xiao B, Bobbala S, Braverman CL, Cai L, Hecker PI, DeBerge M, Thorp EB, Temel RE, Stupp SI, Scott EA Advanced functional materials 34335131 Adv Funct Mater 2019 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/34335131
An Injectable Hydrogel Platform for Sustained Delivery of Anti-inflammatory Nanocarriers and Induction of Regulatory T Cells in Atherosclerosis. Yi S, Karabin NB, Zhu J, Bobbala S, Lyu H, Li S, Liu Y, Frey M, Vincent M, Scott EA Frontiers in bioengineering and biotechnology 32582667 Front Bioeng Biotechnol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32582667
Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence. Du F, Liu YG, Scott EA Cellular and molecular bioengineering 28989540 Cell Mol Bioeng 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28989540
Celastrol-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis. Allen SD , Liu YG , Kim T , Bobbala S , Yi S , Zhang X , Choi J , Scott EA Biomaterials science 30601470 Biomater Sci 2019 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/30601470
Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers. Shang S, Kats D, Cao L, Morgun E, Velluto D, He Y, Xu Q, Wang CR, Scott EA Frontiers in immunology 30538700 Front Immunol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30538700
Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis. Allen S, Liu YG, Scott E Regenerative engineering and translational medicine 27135051 Regen Eng Transl Med 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27135051
Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation. Allen S, Osorio O, Liu YG, Scott E Journal of controlled release : official journal of the Controlled Release Society 28736263 J Control Release 2017 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/28736263
Sustained micellar delivery via inducible transitions in nanostructure morphology. Karabin NB, Allen S, Kwon HK, Bobbala S, Firlar E, Shokuhfar T, Shull KR, Scott EA Nature communications 29434200 Nat Commun 2018 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/29434200
Super-Resolution Imaging of Self-Assembled Nanocarriers Using Quantitative Spectroscopic Analysis for Cluster Extraction. Davis JL, Zhang Y, Yi S, Du F, Song KH, Scott EA, Sun C, Zhang HF Langmuir : the ACS journal of surfaces and colloids 32069413 Langmuir 2020 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/32069413
Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells. Yi S, Kim SY, Vincent MP, Yuk SA, Bobbala S, Du F, Scott EA iScience 35769884 iScience 2022 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/35769884
Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. Zhang S, Yeap XY, DeBerge M, Naresh NK, Wang K, Jiang Z, Wilcox JE, White SM, Morrow JP, Burridge PW, Procissi D, Scott EA, Frazier W, Thorp EB JACC. Basic to translational science 28920097 JACC Basic Transl Sci 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28920097
The Combination of Morphology and Surface Chemistry Defines the Immunological Identity of Nanocarriers in Human Blood. Vincent MP, Karabin NB, Allen SD, Bobbala S, Frey MA, Yi S, Yang Y, Scott EA Advanced therapeutics 34485684 Adv Ther (Weinh) 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34485684
Pi-stacking Enhances Stability, Scalability of Formation, Control over Flexibility and Circulation Time of Polymeric Filaments. Li S, Bobbala S, Vincent MP, Modak M, Liu Y, Scott EA Advanced nanobiomed research 34870281 Adv Nanobiomed Res 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34870281
Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability. Burke JA, Zhang X, Bobbala S, Frey MA, Bohorquez Fuentes C, Freire Haddad H, Allen SD, Richardson RAK, Ameer GA, Scott EA Nature nanotechnology 35039683 Nat Nanotechnol 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35039683
Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets. Vincent MP, Bobbala S, Karabin NB, Frey M, Liu Y, Navidzadeh JO, Stack T, Scott EA Nature communications 33510170 Nat Commun 2021 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/33510170
Influences of nanocarrier morphology on therapeutic immunomodulation. Frey M, Bobbala S, Karabin N, Scott E Nanomedicine (London, England) 30084296 Nanomedicine (Lond) 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/30084296
Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone-sulfone bonding. Du F, Qiao B, Nguyen TD, Vincent MP, Bobbala S, Yi S, Lescott C, Dravid VP, Olvera de la Cruz M, Scott EA Nature communications 32994414 Nat Commun 2020 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/32994414
Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres. Bobbala S , Allen SD , Scott EA Nanoscale 29255814 Nanoscale 2018 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/29255814
Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles. Stack T, Vahabikashi A, Johnson M, Scott E Journal of biomedical materials research. Part A 29468812 J Biomed Mater Res A 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29468812
Employment of targeted nanoparticles for imaging of cellular processes in cardiovascular disease. Modak M, Frey MA, Yi S, Liu Y, Scott EA Current opinion in biotechnology 32682272 Curr Opin Biotechnol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32682272
Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy. Vincent MP, Navidzadeh JO, Bobbala S, Scott EA Cancer cell 35148814 Cancer Cell 2022 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/35148814
Minimizing Molecular Misidentification in Imaging Low-Abundance Protein Interactions Using Spectroscopic Single-Molecule Localization Microscopy. Zhang Y, Wang G, Huang P, Sun E, Kweon J, Li Q, Zhe J, Ying LL, Zhang HF Analytical chemistry 36165784 Anal Chem 2022 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/36165784
Dual Treatment of Chronic Chagasic Cardiomyopathy and Parasitic Burden via Combination Nanotherapy. Staneviciute A, B Scariot D, Liu YG, Qian Y, Sharma S, Mbaye EHA, Almunif S, Engman DM, Scott EA ACS nano 40279477 ACS Nano 2025 May 6 https://www.ncbi.nlm.nih.gov/pubmed/40279477
No sympathy for the hypoxic: the role of fetal oxygenation in autonomic dysfunction. Hoang JD, Vaseghi M The Journal of physiology 29774552 J Physiol 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/29774552
Risk Stratification and Sudden Cardiac Death: Is It Time to Include Autonomic Variables? Khakpour H, Vaseghi M Circulation. Cardiovascular imaging 28794140 Circ Cardiovasc Imaging 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28794140
Cardiac Sympathetic Denervation for Refractory Ventricular Arrhythmias. Vaseghi M, Barwad P, Malavassi Corrales FJ, Tandri H, Mathuria N, Shah R, Sorg JM, Gima J, Mandal K, Sàenz Morales LC, Lokhandwala Y, Shivkumar K Journal of the American College of Cardiology 28641796 J Am Coll Cardiol 2017 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/28641796
Thoracic Epidural Anesthesia Can Be Effective for the Short-Term Management of Ventricular Tachycardia Storm. Do DH, Bradfield J, Ajijola OA, Vaseghi M, Le J, Rahman S, Mahajan A, Nogami A, Boyle NG, Shivkumar K Journal of the American Heart Association 29079570 J Am Heart Assoc 2017 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/29079570
A novel mechanism for regulation of cardiac Ca(2+) current by estradiol: cAMP-ing out at the basal epicardium. Hoang JD, Vaseghi M Heart rhythm 29382545 Heart Rhythm 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29382545
Outcomes of Catheter Ablation of Ventricular Tachycardia Based on Etiology in Nonischemic Heart Disease: An International Ventricular Tachycardia Ablation Center Collaborative Study. Vaseghi M, Hu TY, Tung R, Vergara P, Frankel DS, Di Biase L, Tedrow UB, Gornbein JA, Yu R, Mathuria N, Nakahara S, Tzou WS, Sauer WH, Burkhardt JD, Tholakanahalli VN, Dickfeld TM, Weiss JP, Bunch TJ, Reddy M, Callans DJ, Lakkireddy DR, Natale A, Marchlinski FE, Stevenson WG, Della Bella P, Shivkumar K JACC. Clinical electrophysiology 30236386 JACC Clin Electrophysiol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30236386
Update on prevention and treatment of sudden cardiac arrest. Krokhaleva Y, Vaseghi M Trends in cardiovascular medicine 30449537 Trends Cardiovasc Med 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/30449537
Liver Disease as a Predictor of New-Onset Atrial Fibrillation. Huang WA, Dunipace EA, Sorg JM, Vaseghi M Journal of the American Heart Association 30371253 J Am Heart Assoc 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/30371253
Cardiac neuroanatomy - Imaging nerves to define functional control. Hanna P, Rajendran PS, Ajijola OA, Vaseghi M, Andrew Armour J, Ardell JL, Shivkumar K Autonomic neuroscience : basic & clinical 28802636 Auton Neurosci 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28802636
Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy. Salavatian S, Yamaguchi N, Hoang J, Lin N, Patel S, Ardell JL, Armour JA, Vaseghi M American journal of physiology. Heart and circulatory physiology 31322427 Am J Physiol Heart Circ Physiol 2019 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/31322427
Cardiac sympathetic denervation for intractable ventricular arrhythmias in Chagas disease. Saenz LC, Corrales FM, Bautista W, Traina M, Meymandi S, Rodriguez DA, Tellez LJ, Vaseghi M, Garcia F, Shivkumar K, Bradfield JS Heart rhythm 26969783 Heart Rhythm 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/26969783
Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction. Yamaguchi N, Yamakawa K, Rajendran PS, Takamiya T, Vaseghi M Heart rhythm 29530832 Heart Rhythm 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29530832
Sex and Race/Ethnicity Differences in Atrial Fibrillation. Volgman AS, Bairey Merz CN, Benjamin EJ, Curtis AB, Fang MC, Lindley KJ, Pepine CJ, Vaseghi M, Waldo AL, Wenger NK, Russo AM Journal of the American College of Cardiology 31779796 J Am Coll Cardiol 2019 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/31779796
Cardiac sympathetic activation circumvents high-dose beta blocker therapy in part through release of neuropeptide Y. Hoang JD, Salavatian S, Yamaguchi N, Swid MA, David H, Vaseghi M JCI insight 32493842 JCI Insight 2020 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/32493842
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, Dagres N, Di Toro D, Eckhardt LL, Ellenbogen K, Hardy C, Ikeda T, Jaswal A, Kaufman E, Krahn A, Kusano K, Kutyifa V, Lim HS, Lip GYH, Nava-Townsend S, Pak HN, Rodríguez Diez G, Sauer W, Saxena A, Svendsen JH, Vanegas D, Vaseghi M, Wilde A, Bunch TJ, ESC Scientific Document Group, Buxton AE, Calvimontes G, Chao TF, Eckardt L, Estner H, Gillis AM, Isa R, Kautzner J, Maury P, Moss JD, Nam GB, Olshansky B, Pava Molano LF, Pimentel M, Prabhu M, Tzou WS, Sommer P, Swampillai J, Vidal A, Deneke T, Hindricks G, Leclercq C Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 32538434 Europace 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32538434
Recurrent ventricular tachycardia after cardiac sympathetic denervation: Prolonged cycle length with improved hemodynamic tolerance and ablation outcomes. Hayase J, Dusi V, Do D, Ajijola OA, Vaseghi M, Lee JM, Yanagawa J, Hoftman N, Revels S, Buch EF, Khakpour H, Fujimura O, Krokhaleva Y, Macias C, Sorg J, Gima J, Pavez G, Boyle NG, Shivkumar K, Bradfield JS Journal of cardiovascular electrophysiology 32558054 J Cardiovasc Electrophysiol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32558054
Looking Beyond Storm: Forecast Remains Gloomy for Clustered Ventricular Arrhythmias. Khakpour H, Vaseghi M JACC. Clinical electrophysiology 32192685 JACC Clin Electrophysiol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32192685
Cardiac sympathetic innervation via middle cervical and stellate ganglia and antiarrhythmic mechanism of bilateral stellectomy. Irie T, Yamakawa K, Hamon D, Nakamura K, Shivkumar K, Vaseghi M American journal of physiology. Heart and circulatory physiology 28011590 Am J Physiol Heart Circ Physiol 2017 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/28011590
Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction. Vaseghi M, Salavatian S, Rajendran PS, Yagishita D, Woodward WR, Hamon D, Yamakawa K, Irie T, Habecker BA, Shivkumar K JCI insight 28814663 JCI Insight 2017 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/28814663
Arrhythmogenic Right Ventricular Cardiomyopathy: Electroarchitecture of the Substrate. Watanabe A, Seki A, Fishbein MC, Shivkumar K, Vaseghi M HeartRhythm case reports 26955520 HeartRhythm Case Rep 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26955520
Arrhythmic Risk Profile and Outcomes of Patients Undergoing Cardiac Sympathetic Denervation for Recurrent Monomorphic Ventricular Tachycardia After Ablation. Dusi V, Gornbein J, Do DH, Sorg JM, Khakpour H, Krokhaleva Y, Ajijola OA, Macias C, Bradfield JS, Buch E, Fujimura OA, Boyle NG, Yanagawa J, Lee JM, Shivkumar K, Vaseghi M Journal of the American Heart Association 33441022 J Am Heart Assoc 2021 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/33441022
The autonomic nervous system and ventricular arrhythmias in myocardial infarction and heart failure. Wu P, Vaseghi M Pacing and clinical electrophysiology : PACE 31823401 Pacing Clin Electrophysiol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31823401
Myocardial infarction reduces cardiac nociceptive neurotransmission through the vagal ganglia. Salavatian S, Hoang JD, Yamaguchi N, Lokhandwala ZA, Swid MA, Armour JA, Ardell JL, Vaseghi M JCI insight 35015733 JCI Insight 2022 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/35015733
Editorial Commentary: Chronic obstructive pulmonary disease and sudden cardiac death: Cause and effect or simply an association? Hoffman J, Vaseghi M Trends in cardiovascular medicine 27238054 Trends Cardiovasc Med 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27238054
Microstructural Infarct Border Zone Remodeling in the Post-infarct Swine Heart Measured by Diffusion Tensor MRI. Kung GL, Vaseghi M, Gahm JK, Shevtsov J, Garfinkel A, Shivkumar K, Ennis DB Frontiers in physiology 30246802 Front Physiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30246802
Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Shivkumar K, Ajijola OA, Anand I, Armour JA, Chen PS, Esler M, De Ferrari GM, Fishbein MC, Goldberger JJ, Harper RM, Joyner MJ, Khalsa SS, Kumar R, Lane R, Mahajan A, Po S, Schwartz PJ, Somers VK, Valderrabano M, Vaseghi M, Zipes DP The Journal of physiology 27114333 J Physiol 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27114333
Relationship between sinus rhythm late activation zones and critical sites for scar-related ventricular tachycardia: systematic analysis of isochronal late activation mapping. Irie T, Yu R, Bradfield JS, Vaseghi M, Buch EF, Ajijola O, Macias C, Fujimura O, Mandapati R, Boyle NG, Shivkumar K, Tung R Circulation. Arrhythmia and electrophysiology 25740836 Circ Arrhythm Electrophysiol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25740836
Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death. Huang WA, Boyle NG, Vaseghi M Cardiac electrophysiology clinics 29173409 Card Electrophysiol Clin 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29173409
Ventricular Tachycardia in Dilated Cardiomyopathy: Is it Time for Genetic Testing in All Patients? Nguyen HL, Vaseghi M JACC. Clinical electrophysiology 32972545 JACC Clin Electrophysiol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32972545
Chip-based frequency comb sources for optical coherence tomography. Ji X, Yao X, Klenner A, Gan Y, Gaeta AL, Hendon CP, Lipson M Optics express 31503744 Opt Express 2019 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/31503744
Compressed sensing-enabled phase-sensitive swept-source optical coherence tomography. Ling Y, Meiniel W, Singh-Moon R, Angelini E, Olivo-Marin JC, Hendon CP Optics express 30696165 Opt Express 2019 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/30696165
Optical coherence tomography imaging of cardiac substrates. Hendon CP, Lye TH, Yao X, Gan Y, Marboe CC Quantitative imaging in medicine and surgery 31281782 Quant Imaging Med Surg 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31281782
Multicontrast endomyocardial imaging by single-channel high-resolution cross-polarization optical coherence tomography. Yao X, Gan Y, Ling Y, Marboe CC, Hendon CP Journal of biophotonics 29165902 J Biophotonics 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29165902
Automated classification of optical coherence tomography images of human atrial tissue. Gan Y, Tsay D, Amir SB, Marboe CC, Hendon CP Journal of biomedical optics 26926869 J Biomed Opt 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/26926869
Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process. Mojahed D, Applegate M, Guo H, Taback B, Ha R, Hibshoosh H, Hendon C Journal of biomedical optics 36050827 J Biomed Opt 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36050827
Cardiac endocardial left atrial substrate and lesion depth mapping using near-infrared spectroscopy. Park SY, Yang H, Marboe C, Ziv O, Laurita K, Rollins A, Saluja D, Hendon CP Biomedical optics express 35519253 Biomed Opt Express 2022 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/35519253
Optical coherence tomography-enabled classification of the human venoatrial junction. Joasil AS, Therien AM, Hendon CP Journal of biomedical optics 39840147 J Biomed Opt 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39840147
Compressed sensing of human breast optical coherence 3-D image volume data using predictive coding. Song Cho DM, Jerome MJ, Hendon CP Biomedical optics express 38021138 Biomed Opt Express 2023 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/38021138
Monitoring of irrigated lesion formation with single fiber based multispectral system using machine learning. Park SY, Singh-Moon RP, Yang H, Hendon CP Journal of biophotonics 35666015 J Biophotonics 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35666015
Phase-noise analysis of swept-source optical coherence tomography systems. Ling Y, Gan Y, Yao X, Hendon CP Optics letters 28362762 Opt Lett 2017 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/28362762
Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method. Mojahed D, Ha RS, Chang P, Gan Y, Yao X, Angelini B, Hibshoosh H, Taback B, Hendon CP Academic radiology 31324579 Acad Radiol 2020 May https://www.ncbi.nlm.nih.gov/pubmed/31324579
Imaging of subendocardial adipose tissue and fiber orientation distributions in the human left atrium using optical coherence tomography. Lye TH, Marboe CC, Hendon CP Journal of cardiovascular electrophysiology 31661178 J Cardiovasc Electrophysiol 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31661178
Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Women. Yao W, Gan Y, Myers KM, Vink JY, Wapner RJ, Hendon CP PloS one 27898677 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27898677
Cardiac Adipose Tissue Segmentation via Image-Level Annotations. Huang Z, Gan Y, Lye T, Liu Y, Zhang H, Laine A, Angelini E, Hendon C IEEE journal of biomedical and health informatics 37023157 IEEE J Biomed Health Inform 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37023157
Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography. Ling Y, Yao X, Gamm UA, Arteaga-Solis E, Emala CW, Choma MA, Hendon CP Lasers in surgery and medicine 28231402 Lasers Surg Med 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28231402
Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography. Yao X, Gan Y, Marboe CC, Hendon CP Journal of biomedical optics 27001162 J Biomed Opt 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27001162
Analyzing three-dimensional ultrastructure of human cervical tissue using optical coherence tomography. Gan Y, Yao W, Myers KM, Vink JY, Wapner RJ, Hendon CP Biomedical optics express 25908997 Biomed Opt Express 2015 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/25908997
Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT. Yao X, Gan Y, Chang E, Hibshoosh H, Feldman S, Hendon C Lasers in surgery and medicine 28264146 Lasers Surg Med 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28264146
An automated 3D registration method for optical coherence tomography volumes. Gan Y, Yao W, Myers KM, Hendon CP Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 25570837 Annu Int Conf IEEE Eng Med Biol Soc 2014 https://www.ncbi.nlm.nih.gov/pubmed/25570837
Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT. McLean JP, Fang S, Gallos G, Myers KM, Hendon CP Biomedical optics express 33149968 Biomed Opt Express 2020 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/33149968
Characterization of the human myocardium by optical coherence tomography. Gan Y, Lye TH, Marboe CC, Hendon CP Journal of biophotonics 31400074 J Biophotonics 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31400074
Mapping the human pulmonary venoatrial junction with optical coherence tomography. Lye TH, Iyer V, Marboe CC, Hendon CP Biomedical optics express 30800491 Biomed Opt Express 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30800491
Quantification of irrigated lesion morphology using near-infrared spectroscopy. Park SY, Singh-Moon R, Yang H, Saluja D, Hendon C Scientific reports 34635764 Sci Rep 2021 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/34635764
Comparative study of texture features in OCT images at different scales for human breast tissue classification. Yu Gan, Xinwen Yao, Chang E, Bin Amir S, Hibshoosh H, Feldman S, Hendon CP Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 28269144 Annu Int Conf IEEE Eng Med Biol Soc 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/28269144
Millimeter-scale chip-based supercontinuum generation for optical coherence tomography. Ji X, Mojahed D, Okawachi Y, Gaeta AL, Hendon CP, Lipson M Science advances 34533990 Sci Adv 2021 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/34533990
Real-time optical spectroscopic monitoring of nonirrigated lesion progression within atrial and ventricular tissues. Singh-Moon RP, Yao X, Iyer V, Marboe C, Whang W, Hendon CP Journal of biophotonics 30058239 J Biophotonics 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30058239
Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging. McLean JP, Ling Y, Hendon CP Optics express 29041245 Opt Express 2017 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/29041245
Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation. Singh-Moon RP, Marboe CC, Hendon CP Biomedical optics express 26203376 Biomed Opt Express 2015 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/26203376
A continuous fiber distribution material model for human cervical tissue. Myers KM, Hendon CP, Gan Y, Yao W, Yoshida K, Fernandez M, Vink J, Wapner RJ Journal of biomechanics 25817474 J Biomech 2015 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/25817474
Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector. Ling Y, Yao X, Hendon CP Biomedical optics express 29082103 Biomed Opt Express 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/29082103
Heterogeneity Measurement of Cardiac Tissues Leveraging Uncertainty Information from Image Segmentation. Huang Z, Gan Y, Lye T, Zhang H, Laine A, Angelini ED, Hendon C Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 34169298 Med Image Comput Comput Assist Interv 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/34169298
3-D compressed sensing optical coherence tomography using predictive coding. McLean JP, Hendon CP Biomedical optics express 33996246 Biomed Opt Express 2021 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/33996246
Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography. Lye TH, Vincent KP, McCulloch AD, Hendon CP Biophysical journal 29590604 Biophys J 2018 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/29590604
Feasibility of near-infrared spectroscopy as a tool for anatomical mapping of the human epicardium. Singh-Moon RP, Park SY, Song Cho DM, Vaidya A, Marboe CC, Wan EY, Hendon CP Biomedical optics express 32923031 Biomed Opt Express 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32923031
In Vivo Clonal Analysis of Cardiomyocytes. Nguyen NB, Fernandez GE, Ding Y, Hsiai T, Ardehali R Methods in molecular biology (Clifton, N.J.) 32857378 Methods Mol Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/32857378
Biomarkers of Human Pluripotent Stem Cell-Derived Cardiac Lineages. Skelton RJP, Kamp TJ, Elliott DA, Ardehali R Trends in molecular medicine 28576602 Trends Mol Med 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28576602
Arrhythmia in stem cell transplantation. Almeida SO, Skelton RJ, Adigopula S, Ardehali R Cardiac electrophysiology clinics 26002399 Card Electrophysiol Clin 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/26002399
Translational aspects of cardiac cell therapy. Chen CH, Sereti KI, Wu BM, Ardehali R Journal of cellular and molecular medicine 26119413 J Cell Mol Med 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26119413
Direct cardiac reprogramming: A new frontier in heart regeneration. Ardehali R Seminars in cell & developmental biology 34538519 Semin Cell Dev Biol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34538519
Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK Scientific reports 26935567 Sci Rep 2016 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/26935567
Harnessing the versatility of PLGA nanoparticles for targeted Cre-mediated recombination. Nguyen NB, Chen CH, Zhang Y, Zhao P, Wu BM, Ardehali R Nanomedicine : nanotechnology, biology, and medicine 31026512 Nanomedicine 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31026512
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R Circulation 29950403 Circulation 2018 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/29950403
Direct Cardiac Reprogramming: Progress and Promise. Engel JL, Ardehali R Stem cells international 29731772 Stem Cells Int 2018 https://www.ncbi.nlm.nih.gov/pubmed/29731772
Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts. Ranjbarvaziri S, Park S, Nguyen NB, Gilmore WB, Zhao P, Ardehali R Genesis (New York, N.Y. : 2000) 28589709 Genesis 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28589709
Cardiac fibrosis: potential therapeutic targets. Park S, Nguyen NB, Pezhouman A, Ardehali R Translational research : the journal of laboratory and clinical medicine 30930180 Transl Res 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30930180
Environmental factors influence somatic cell reprogramming to cardiomyocyte-like cells. Van Handel B, Wang L, Ardehali R Seminars in cell & developmental biology 34083115 Semin Cell Dev Biol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34083115
Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure. Park S, Ranjbarvaziri S, Zhao P, Ardehali R JACC. Basic to translational science 32478206 JACC Basic Transl Sci 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32478206
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R Nature communications 29467410 Nat Commun 2018 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/29467410
Sendai virus based direct cardiac reprogramming: what lies ahead? Engel JL, Ardehali R Stem cell investigation 30498748 Stem Cell Investig 2018 https://www.ncbi.nlm.nih.gov/pubmed/30498748
Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. He L, Nguyen NB, Ardehali R, Zhou B Circulation 32687441 Circulation 2020 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/32687441
HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1. Liu J, Li Y, Lin B, Sheng Y, Yang L Developmental cell 28829943 Dev Cell 2017 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/28829943
Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC, Rasmusson RL, London B, Salama G Journal of molecular and cellular cardiology 25644533 J Mol Cell Cardiol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25644533
HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1. Liu J, Li Y, Lin B, Sheng Y, Yang L Developmental cell 29112854 Dev Cell 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/29112854
Genome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells. Liu J, Liu S, Gao H, Han L, Chu X, Sheng Y, Shou W, Wang Y, Liu Y, Wan J, Yang L Genome biology 32646524 Genome Biol 2020 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/32646524
Comparative transcriptomic analysis of multiple cardiovascular fates from embryonic stem cells predicts novel regulators in human cardiogenesis. Li Y, Lin B, Yang L Scientific reports 25997157 Sci Rep 2015 May 21 https://www.ncbi.nlm.nih.gov/pubmed/25997157
Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L Disease models & mechanisms 25791035 Dis Model Mech 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25791035
A microphysiological model of the human placental barrier. Blundell C, Tess ER, Schanzer AS, Coutifaris C, Su EJ, Parry S, Huh D Lab on a chip 27229450 Lab Chip 2016 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/27229450
Organoids-on-a-chip. Park SE, Georgescu A, Huh D Science (New York, N.Y.) 31171693 Science 2019 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/31171693
A microengineered model of RBC transfusion-induced pulmonary vascular injury. Seo J, Conegliano D, Farrell M, Cho M, Ding X, Seykora T, Qing D, Mangalmurti NS, Huh D Scientific reports 28611413 Sci Rep 2017 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/28611413
Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier. Blundell C, Yi YS, Ma L, Tess ER, Farrell MJ, Georgescu A, Aleksunes LM, Huh D Advanced healthcare materials 29121458 Adv Healthc Mater 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29121458
Soft robotic constrictor for in vitro modeling of dynamic tissue compression. Paek J, Song JW, Ban E, Morimitsu Y, Osuji CO, Shenoy VB, Huh DD Scientific reports 34389738 Sci Rep 2021 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/34389738
In Vitro Granuloma Models of Tuberculosis: Potential and Challenges. Elkington P, Lerm M, Kapoor N, Mahon R, Pienaar E, Huh D, Kaushal D, Schlesinger LS The Journal of infectious diseases 30929010 J Infect Dis 2019 May 24 https://www.ncbi.nlm.nih.gov/pubmed/30929010
Multiscale reverse engineering of the human ocular surface. Seo J, Byun WY, Alisafaei F, Georgescu A, Yi YS, Massaro-Giordano M, Shenoy VB, Lee V, Bunya VY, Huh D Nature medicine 31384041 Nat Med 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31384041
Placenta-on-a-chip: a novel platform to study the biology of the human placenta. Lee JS, Romero R, Han YM, Kim HC, Kim CJ, Hong JS, Huh D The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 26075842 J Matern Fetal Neonatal Med 2016 https://www.ncbi.nlm.nih.gov/pubmed/26075842
A bioinspired microfluidic model of liquid plug-induced mechanical airway injury. Song JW, Paek J, Park KT, Seo J, Huh D Biomicrofluidics 29887935 Biomicrofluidics 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29887935
A Human Vascular Injury-on-a-Chip Model of Hemostasis. Poventud-Fuentes I, Kwon KW, Seo J, Tomaiuolo M, Stalker TJ, Brass LF, Huh D Small (Weinheim an der Bergstrasse, Germany) 33150735 Small 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33150735
Organs-on-chips at the frontiers of drug discovery. Esch EW, Bahinski A, Huh D Nature reviews. Drug discovery 25792263 Nat Rev Drug Discov 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25792263
Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture. Mondrinos MJ, Yi YS, Wu NK, Ding X, Huh D Lab on a chip 28809418 Lab Chip 2017 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/28809418
Polydopamine-Based Interfacial Engineering of Extracellular Matrix Hydrogels for the Construction and Long-Term Maintenance of Living Three-Dimensional Tissues. Park SE, Georgescu A, Oh JM, Kwon KW, Huh D ACS applied materials & interfaces 31199616 ACS Appl Mater Interfaces 2019 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/31199616
Geometric engineering of organoid culture for enhanced organogenesis in a dish. Park SE, Kang S, Paek J, Georgescu A, Chang J, Yi AY, Wilkins BJ, Karakasheva TA, Hamilton KE, Huh DD Nature methods 36280722 Nat Methods 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36280722
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip. Georgescu A, Oved JH, Galarraga JH, Cantrell T, Mehta S, Dulmovits BM, Olson TS, Fattahi P, Wang A, Candarlioglu PL, Muvaffak A, Kim MM, Aydin SA, Seo J, Diffenderfer ES, Lynch A, Worthen GS, Huh DD Cell stem cell 39642865 Cell Stem Cell 2024 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/39642865
Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue. Mondrinos MJ, Alisafaei F, Yi AY, Ahmadzadeh H, Lee I, Blundell C, Seo J, Osborn M, Jeon TJ, Kim SM, Shenoy VB, Huh D Science advances 33712463 Sci Adv 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33712463
A microengineered pathophysiological model of early-stage breast cancer. Choi Y, Hyun E, Seo J, Blundell C, Kim HC, Lee E, Lee SH, Moon A, Moon WK, Huh D Lab on a chip 26158500 Lab Chip 2015 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/26158500
Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D ACS nano 31194909 ACS Nano 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31194909
Immune Modulation to Improve Survival of Viral Pneumonia in Mice. Wali S, Flores JR, Jaramillo AM, Goldblatt DL, Pantaleón García J, Tuvim MJ, Dickey BF, Evans SE American journal of respiratory cell and molecular biology 32853024 Am J Respir Cell Mol Biol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32853024
Bacterial Pneumonia in Patients with Cancer: Novel Risk Factors and Management. Wong JL, Evans SE Clinics in chest medicine 28477638 Clin Chest Med 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28477638
Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense. Leiva-Juárez MM, Kolls JK, Evans SE Mucosal immunology 28812547 Mucosal Immunol 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28812547
Muc5b is required for airway defence. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM Nature 24317696 Nature 2014 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/24317696
Viral Pneumonia in Patients with Hematologic Malignancy or Hematopoietic Stem Cell Transplantation. Vakil E, Evans SE Clinics in chest medicine 28159165 Clin Chest Med 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28159165
Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming. Wang Y, Kulkarni VV, Pantaleón García J, Leiva-Juárez MM, Goldblatt DL, Gulraiz F, Chen J, Donepudi SR, Lorenzi PL, Wang H, Wong LJ, Tuvim MJ, Evans SE bioRxiv : the preprint server for biology 36711510 bioRxiv 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36711510
Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice. Goldblatt DL, Valverde Ha G, Wali S, Kulkarni VV, Longmire MK, Jaramillo AM, Chittuluru RP, Fouts A, Martinez-Moczygemba M, Lei JT, Huston DP, Tuvim MJ, Dickey BF, Evans SE Frontiers in pharmacology 36105216 Front Pharmacol 2022 https://www.ncbi.nlm.nih.gov/pubmed/36105216
Minimizing caging effects in murine lung microbiome studies. Pantaleón García J, Dickson RP, Evans SE American journal of physiology. Lung cellular and molecular physiology 35944140 Am J Physiol Lung Cell Mol Physiol 2022 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/35944140
Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir. Leiva-Juarez MM, Kirkpatrick CT, Gilbert BE, Scott B, Tuvim MJ, Dickey BF, Evans SE, Markesich D European journal of pharmacology 29066417 Eur J Pharmacol 2018 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/29066417
Future Research Directions in Pneumonia. NHLBI Working Group Report. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP American journal of respiratory and critical care medicine 29546996 Am J Respir Crit Care Med 2018 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/29546996
Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections. Kirkpatrick CT, Wang Y, Leiva Juarez MM, Shivshankar P, Pantaleón García J, Plumer AK, Kulkarni VV, Ware HH, Gulraiz F, Chavez Cavasos MA, Martinez Zayas G, Wali S, Rice AP, Liu H, Tour JM, Sikkema WKA, Cruz Solbes AS, Youker KA, Tuvim MJ, Dickey BF, Evans SE mBio 29764948 mBio 2018 May 15 https://www.ncbi.nlm.nih.gov/pubmed/29764948
Fungal Pneumonia in Patients with Hematologic Malignancy and Hematopoietic Stem Cell Transplantation. Young AY, Leiva Juarez MM, Evans SE Clinics in chest medicine 28797490 Clin Chest Med 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28797490
Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response. Xia X, Mai J, Xu R, Perez JET, Guevara ML, Shen Q, Mu C, Tung HY, Corry DB, Evans SE, Liu X, Ferrari M, Zhang Z, Li XC, Wang RF, Shen H Cell reports 25937283 Cell Rep 2015 May 12 https://www.ncbi.nlm.nih.gov/pubmed/25937283
Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands. Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF Frontiers in pharmacology 24567720 Front Pharmacol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24567720
Selective Modulation of the Pulmonary Innate Immune Response Does Not Change Lung Microbiota in Healthy Mice. Pantaleón García J, Hinkle KJ, Falkowski NR, Evans SE, Dickson RP American journal of respiratory and critical care medicine 34153197 Am J Respir Crit Care Med 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34153197
Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases. Smith AM, Harper N, Meunier JA, Branum AP, Jimenez F, Pandranki L, Carrillo A, Dela Cruz CS, Restrepo MI, Maselli DJ, Rather CG, Heisser AH, Ramirez DA, He W, Clark RA, Andrews CP, Evans SE, Pugh JA, Zhang N, Lee GC, Moreira AG, Segal LN, Ramirez RM, Jacobs RL, Manoharan MS, Okulicz JF, Ahuja SK The Journal of allergy and clinical immunology 33493557 J Allergy Clin Immunol 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33493557
Pneumonia in the neutropenic cancer patient. Evans SE, Ost DE Current opinion in pulmonary medicine 25784246 Curr Opin Pulm Med 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25784246
The development and plasticity of alveolar type 1 cells. Yang J, Hernandez BJ, Martinez Alanis D, Narvaez del Pilar O, Vila-Ellis L, Akiyama H, Evans SE, Ostrin EJ, Chen J Development (Cambridge, England) 26586225 Development 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26586225
MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT JCI insight 30944250 JCI Insight 2019 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/30944250
Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. Goldblatt DL, Flores JR, Valverde Ha G, Jaramillo AM, Tkachman S, Kirkpatrick CT, Wali S, Hernandez B, Ost DE, Scott BL, Chen J, Evans SE, Tuvim MJ, Dickey BF British journal of pharmacology 31968123 Br J Pharmacol 2020 May https://www.ncbi.nlm.nih.gov/pubmed/31968123
Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections. Ware HH, Kulkarni VV, Wang Y, Pantaleón García J, Leiva Juarez M, Kirkpatrick CT, Wali S, Syed S, Kontoyiannis AD, Sikkema WKA, Tour JM, Evans SE PloS one 30794556 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/30794556
Editorial: Purinergic Signaling and Inflammation. Yuan X, Ferrari D, Mills T, Wang Y, Czopik A, Doursout MF, Evans SE, Idzko M, Eltzschig HK Frontiers in immunology 34093597 Front Immunol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34093597
Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation. Czopik A, Yuan X, Evans SE, Eltzschig HK Anesthesiology 34046661 Anesthesiology 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/34046661
Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation. Wang Y, Kulkarni VV, Pantaleón García J, Leiva-Juárez MM, Goldblatt DL, Gulraiz F, Vila Ellis L, Chen J, Longmire MK, Donepudi SR, Lorenzi PL, Wang H, Wong LJ, Tuvim MJ, Evans SE PLoS pathogens 37695784 PLoS Pathog 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37695784
OBIF: an omics-based interaction framework to reveal molecular drivers of synergy. Pantaleón García J, Kulkarni VV, Reese TC, Wali S, Wase SJ, Zhang J, Singh R, Caetano MS, Kadara H, Moghaddam SJ, Johnson FM, Wang J, Wang Y, Evans SE NAR genomics and bioinformatics 35387383 NAR Genom Bioinform 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35387383
Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia. Kulkarni VV, Wang Y, Pantaleon Garcia J, Evans SE American journal of respiratory cell and molecular biology 36826841 Am J Respir Cell Mol Biol 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/36826841
Inducible epithelial resistance protects mice against leukemia-associated pneumonia. Leiva-Juárez MM, Ware HH, Kulkarni VV, Zweidler-McKay PA, Tuvim MJ, Evans SE Blood 27317793 Blood 2016 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/27317793
Progression of the Radiologic Severity Index predicts mortality in patients with parainfluenza virus-associated lower respiratory infections. Sheshadri A, Shah DP, Godoy M, Erasmus JJ, Song J, Li L, Evans SE, Chemaly RF, Dickey BF, Ost DE PloS one 29771962 PLoS One 2018 https://www.ncbi.nlm.nih.gov/pubmed/29771962
Lung epithelial cells are essential effectors of inducible resistance to pneumonia. Cleaver JO, You D, Michaud DR, Pruneda FA, Juarez MM, Zhang J, Weill PM, Adachi R, Gong L, Moghaddam SJ, Poynter ME, Tuvim MJ, Evans SE Mucosal immunology 23632328 Mucosal Immunol 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23632328
Toll-like receptor-2/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs. Drake MG, Evans SE, Dickey BF, Fryer AD, Jacoby DB American journal of respiratory cell and molecular biology 23449736 Am J Respir Cell Mol Biol 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23449736
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo. Covés-Datson EM, King SR, Legendre M, Gupta A, Chan SM, Gitlin E, Kulkarni VV, Pantaleón García J, Smee DF, Lipka E, Evans SE, Tarbet EB, Ono A, Markovitz DM Proceedings of the National Academy of Sciences of the United States of America 31932446 Proc Natl Acad Sci U S A 2020 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/31932446
The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival. Wang Y, Kulkarni VV, PantaleónGarcía J, Longmire MK, Lethier M, Cusack S, Evans SE JCI insight 39352770 JCI Insight 2024 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/39352770
Machine Learning in Medicine. Deo RC Circulation 26572668 Circulation 2015 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/26572668
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia. Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC Nature structural & molecular biology 33046906 Nat Struct Mol Biol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33046906
An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia. Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret A, Green MS, Rutberg J, Balaji S, Cadrin-Tourigny J, Orland KM, Knight LM, Brateng C, Wu J, Tang AS, Skanes AC, Manlucu J, Healey JS, January CT, Krahn AD, Collins KK, Maginot KR, Fischbach P, Etheridge SP, Eckhardt LL, Hamilton RM, Ackerman MJ, Noguer FRI, Semsarian C, Jura N, Leenhardt A, Gollob MH, Priori SG, Sanatani S, Wilde AAM, Deo RC, Roberts JD Circulation 32693635 Circulation 2020 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/32693635
Phenomapping for novel classification of heart failure with preserved ejection fraction. Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang CC, Deo RC Circulation 25398313 Circulation 2015 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/25398313
Learning About Machine Learning: The Promise and Pitfalls of Big Data and the Electronic Health Record. Deo RC, Nallamothu BK Circulation. Cardiovascular quality and outcomes 28263936 Circ Cardiovasc Qual Outcomes 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/28263936
Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB Circulation 32202936 Circulation 2020 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/32202936
RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells. Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D Circulation research 25623957 Circ Res 2015 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/25623957
Automated and Interpretable Patient ECG Profiles for Disease Detection, Tracking, and Discovery. Tison GH, Zhang J, Delling FN, Deo RC Circulation. Cardiovascular quality and outcomes 31525078 Circ Cardiovasc Qual Outcomes 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31525078
Response by Zhang and Deo to Letter Regarding Article, "Fully Automated Echocardiogram Interpretation in Clinical Practice: Feasibility and Diagnostic Accuracy". Zhang J, Deo RC Circulation 30908098 Circulation 2019 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/30908098
Precision Phenotyping of Dilated Cardiomyopathy Using Multidimensional Data. Tayal U, Verdonschot JAJ, Hazebroek MR, Howard J, Gregson J, Newsome S, Gulati A, Pua CJ, Halliday BP, Lota AS, Buchan RJ, Whiffin N, Kanapeckaite L, Baruah R, Jarman JWE, O'Regan DP, Barton PJR, Ware JS, Pennell DJ, Adriaans BP, Bekkers SCAM, Donovan J, Frenneaux M, Cooper LT, Januzzi JL Jr, Cleland JGF, Cook SA, Deo RC, Heymans SRB, Prasad SK Journal of the American College of Cardiology 35654493 J Am Coll Cardiol 2022 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/35654493
Alternative Splicing, Internal Promoter, Nonsense-Mediated Decay, or All Three: Explaining the Distribution of Truncation Variants in Titin. Deo RC Circulation. Cardiovascular genetics 27625338 Circ Cardiovasc Genet 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27625338
Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation. Roberts JD, Longoria J, Poon A, Gollob MH, Dewland TA, Kwok PY, Olgin JE, Deo RC, Marcus GM Circulation. Cardiovascular genetics 25406240 Circ Cardiovasc Genet 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25406240
An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC eLife 26473617 Elife 2015 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/26473617
Prioritizing causal disease genes using unbiased genomic features. Deo RC, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP Genome biology 25633252 Genome Biol 2014 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/25633252
A case of mistaken identity: The MAR-1 antibody to mouse FcεRIα cross-reacts with FcγRI and FcγRIV. Tang XZ, Jung JB, Allen CDC The Journal of allergy and clinical immunology 30639345 J Allergy Clin Immunol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30639345
Bronchus-associated macrophages efficiently capture and present soluble inhaled antigens and are capable of local Th2 cell activation. Tang XZ, Kreuk LSM, Cho C, Metzger RJ, Allen CDC eLife 36173678 Elife 2022 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/36173678
Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M Frontiers in immunology 35634278 Front Immunol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35634278
Expression of Exogenous Genes in Murine Primary B Cells and B Cell Lines Using Retroviral Vectors. Yang Z, Allen CDC Methods in molecular biology (Clifton, N.J.) 29388098 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29388098
Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB The Journal of clinical investigation 33956668 J Clin Invest 2021 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/33956668
Regulatory constraints in the generation and differentiation of IgE-expressing B cells. Yang Z, Robinson MJ, Allen CD Current opinion in immunology 24632082 Curr Opin Immunol 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24632082
Study of IgE-Producing B Cells Using the Verigem Fluorescent Reporter Mouse. Yang Z, Jung JB, Allen CDC Methods in molecular biology (Clifton, N.J.) 29956157 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29956157
Spontaneous Helical Structure Formation in Laminin Nanofibers. Szymanski JM, Ba M, Feinberg AW Journal of materials chemistry. B 26693018 J Mater Chem B 2015 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/26693018
Engineered Basement Membranes for Regenerating the Corneal Endothelium. Palchesko RN, Funderburgh JL, Feinberg AW Advanced healthcare materials 27723276 Adv Healthc Mater 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27723276
Stretch-dependent changes in molecular conformation in fibronectin nanofibers. Szymanski JM, Sevcik EN, Zhang K, Feinberg AW Biomaterials science 28612067 Biomater Sci 2017 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/28612067
Measuring the Poisson's Ratio of Fibronectin Using Engineered Nanofibers. Szymanski JM, Zhang K, Feinberg AW Scientific reports 29042643 Sci Rep 2017 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/29042643
Shrink Wrapping Cells in a Defined Extracellular Matrix to Modulate the Chemo-Mechanical Microenvironment. Palchesko RN, Szymanski JM, Sahu A, Feinberg AW Cellular and molecular bioengineering 25530816 Cell Mol Bioeng 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25530816
In vitro expansion of corneal endothelial cells on biomimetic substrates. Palchesko RN, Lathrop KL, Funderburgh JL, Feinberg AW Scientific reports 25609008 Sci Rep 2015 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/25609008
Fabrication of freestanding alginate microfibers and microstructures for tissue engineering applications. Szymanski JM, Feinberg AW Biofabrication 24695323 Biofabrication 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24695323
Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues. Jeon O, Bin Lee Y, Hinton TJ, Feinberg AW, Alsberg E Materials today. Chemistry 30778400 Mater Today Chem 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30778400
Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces. Sun Y, Jallerat Q, Szymanski JM, Feinberg AW Nature methods 25506720 Nat Methods 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25506720
Engineering aligned human cardiac muscle using developmentally inspired fibronectin micropatterns. Batalov I, Jallerat Q, Kim S, Bliley J, Feinberg AW Scientific reports 34075068 Sci Rep 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/34075068
Engineering Aligned Skeletal Muscle Tissue Using Decellularized Plant-Derived Scaffolds. Cheng YW, Shiwarski DJ, Ball RL, Whitehead KA, Feinberg AW ACS biomaterials science & engineering 33463300 ACS Biomater Sci Eng 2020 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33463300
ECM protein nanofibers and nanostructures engineered using surface-initiated assembly. Szymanski JM, Jallerat Q, Feinberg AW Journal of visualized experiments : JoVE 24799041 J Vis Exp 2014 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/24799041
Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue. Shiwarski DJ, Tashman JW, Tsamis A, Bliley JM, Blundon MA, Aranda-Michel E, Jallerat Q, Szymanski JM, McCartney BM, Feinberg AW Nature communications 33208732 Nat Commun 2020 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/33208732
Large volume syringe pump extruder for desktop 3D printers. Pusch K, Hinton TJ, Feinberg AW HardwareX 30498799 HardwareX 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/30498799
3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding. Hinton TJ, Hudson A, Pusch K, Lee A, Feinberg AW ACS biomaterials science & engineering 27747289 ACS Biomater Sci Eng 2016 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/27747289
Understanding the Role of ECM Protein Composition and Geometric Micropatterning for Engineering Human Skeletal Muscle. Duffy RM, Sun Y, Feinberg AW Annals of biomedical engineering 26983843 Ann Biomed Eng 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26983843
Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels. Hinton TJ, Jallerat Q, Palchesko RN, Park JH, Grodzicki MS, Shue HJ, Ramadan MH, Hudson AR, Feinberg AW Science advances 26601312 Sci Adv 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26601312
Patterning on Topography for Generation of Cell Culture Substrates with Independent Nanoscale Control of Chemical and Topographical Extracellular Matrix Cues. Sevcik EN, Szymanski JM, Jallerat Q, Feinberg AW Current protocols in cell biology 28627752 Curr Protoc Cell Biol 2017 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/28627752
Extracellular Matrix Structure and Composition in the Early Four-Chambered Embryonic Heart. Jallerat Q, Feinberg AW Cells 31991580 Cells 2020 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/31991580
3D bioprinting of collagen to rebuild components of the human heart. Lee A, Hudson AR, Shiwarski DJ, Tashman JW, Hinton TJ, Yerneni S, Bliley JM, Campbell PG, Feinberg AW Science (New York, N.Y.) 31371612 Science 2019 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/31371612
Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype. Bliley JM, Vermeer MCSC, Duffy RM, Batalov I, Kramer D, Tashman JW, Shiwarski DJ, Lee A, Teplenin AS, Volkers L, Coffin B, Hoes MF, Kalmykov A, Palchesko RN, Sun Y, Jongbloed JDH, Bomer N, de Boer RA, Suurmeijer AJH, Pijnappels DA, Bolling MC, van der Meer P, Feinberg AW Science translational medicine 34290054 Sci Transl Med 2021 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/34290054
Cell-free compartmentalized protein synthesis inside double emulsion templated liposomes with in vitro synthesized and assembled ribosomes. Caschera F, Lee JW, Ho KK, Liu AP, Jewett MC Chemical communications (Cambridge, England) 27019994 Chem Commun (Camb) 2016 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/27019994
Cofactoring and dimerization of proteinase-activated receptors. Lin H, Liu AP, Smith TH, Trejo J Pharmacological reviews 24064459 Pharmacol Rev 2013 https://www.ncbi.nlm.nih.gov/pubmed/24064459
Cell-sized mechanosensitive and biosensing compartment programmed with DNA. Majumder S, Garamella J, Wang YL, DeNies M, Noireaux V, Liu AP Chemical communications (Cambridge, England) 28524182 Chem Commun (Camb) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28524182
Lipid bilayer vesicle generation using microfluidic jetting. Coyne CW, Patel K, Heureaux J, Stachowiak J, Fletcher DA, Liu AP Journal of visualized experiments : JoVE 24637415 J Vis Exp 2014 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/24637415
Activation of a bacterial mechanosensitive channel in mammalian cells by cytoskeletal stress. Heureaux J, Chen D, Murray VL, Deng CX, Liu AP Cellular and molecular bioengineering 25606062 Cell Mol Bioeng 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25606062
Simultaneous monitoring of transcription and translation in mammalian cell-free expression in bulk and in cell-sized droplets. Wang S, Majumder S, Emery NJ, Liu AP Synthetic biology (Oxford, England) 30003145 Synth Biol (Oxf) 2018 https://www.ncbi.nlm.nih.gov/pubmed/30003145
The rise of bottom-up synthetic biology and cell-free biology. Liu AP Physical biology 31018188 Phys Biol 2019 May 7 https://www.ncbi.nlm.nih.gov/pubmed/31018188
Development of an advanced microfluidic micropipette aspiration device for single cell mechanics studies. Lee LM, Lee JW, Chase D, Gebrezgiabhier D, Liu AP Biomicrofluidics 27703591 Biomicrofluidics 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27703591
Protein aggregation with poly(vinyl) alcohol surfactant reduces double emulsion-encapsulated mammalian cell-free expression. Ho KK, Lee JW, Durand G, Majumder S, Liu AP PloS one 28358875 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/28358875
Bottom-up synthetic biology: modular design for making artificial platelets. Majumder S, Liu AP Physical biology 29091050 Phys Biol 2017 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/29091050
The Application of Micropipette Aspiration in Molecular Mechanics of Single Cells. Lee LM, Liu AP Journal of nanotechnology in engineering and medicine 26155329 J Nanotechnol Eng Med 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/26155329
Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling. Liu AP Biophysical journal 27456131 Biophys J 2016 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/27456131
Engineering artificial cells by combining HeLa-based cell-free expression and ultrathin double emulsion template. Ho KK, Murray VL, Liu AP Methods in cell biology 25997354 Methods Cell Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25997354
Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions. Shao Y, Tan X, Novitski R, Muqaddam M, List P, Williamson L, Fu J, Liu AP The Review of scientific instruments 24289415 Rev Sci Instrum 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24289415
Mechanically activated artificial cell by using microfluidics. Ho KK, Lee LM, Liu AP Scientific reports 27610921 Sci Rep 2016 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/27610921
A microfluidic pipette array for mechanophenotyping of cancer cells and mechanical gating of mechanosensitive channels. Lee LM, Liu AP Lab on a chip 25361042 Lab Chip 2015 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/25361042
Synergistic and non-specific nucleic acid production by T7 RNA polymerase and Bsu DNA polymerase catalyzed by single-stranded polynucleotides. Emery NJ, Majumder S, Liu AP Synthetic and systems biotechnology 29900426 Synth Syst Biotechnol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29900426
Multiplex detection of homo- and heterodimerization of g protein-coupled receptors by proximity biotinylation. Steel E, Murray VL, Liu AP PloS one 24691126 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24691126
Advanced Microfluidic Device Designed for Cyclic Compression of Single Adherent Cells. Ho KKY, Wang YL, Wu J, Liu AP Frontiers in bioengineering and biotechnology 30386779 Front Bioeng Biotechnol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30386779
Gel-forming mucins form distinct morphologic structures in airways. Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ Proceedings of the National Academy of Sciences of the United States of America 28607090 Proc Natl Acad Sci U S A 2017 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/28607090
Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways. Xie Y, Ostedgaard L, Abou Alaiwa MH, Lu L, Fischer AJ, Stoltz DA Annals of the American Thoracic Society 30431346 Ann Am Thorac Soc 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30431346
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Hoegger MJ, Fischer AJ, McMenimen JD, Ostedgaard LS, Tucker AJ, Awadalla MA, Moninger TO, Michalski AS, Hoffman EA, Zabner J, Stoltz DA, Welsh MJ Science (New York, N.Y.) 25124441 Science 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/25124441
Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs. Hoegger MJ, Awadalla M, Namati E, Itani OA, Fischer AJ, Tucker AJ, Adam RJ, McLennan G, Hoffman EA, Stoltz DA, Welsh MJ Proceedings of the National Academy of Sciences of the United States of America 24474805 Proc Natl Acad Sci U S A 2014 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/24474805
Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis. Diwakar A, Adam RJ, Michalski AS, Tamegnon MM, Fischer AJ, Launspach JL, Horan RA, Kao SC, Chaloner K, Meyerholz DK, Stoltz DA The Laryngoscope 25827636 Laryngoscope 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25827636
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA 4th, Hoffman EA, Chang EH, Zabner J, McCray PB Jr, Prather RS, Meyerholz DK, Welsh MJ The Journal of clinical investigation 23676501 J Clin Invest 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23676501
Air trapping and airflow obstruction in newborn cystic fibrosis piglets. Adam RJ, Michalski AS, Bauer C, Abou Alaiwa MH, Gross TJ, Awadalla MS, Bouzek DC, Gansemer ND, Taft PJ, Hoegger MJ, Diwakar A, Ochs M, Reinhardt JM, Hoffman EA, Beichel RR, Meyerholz DK, Stoltz DA American journal of respiratory and critical care medicine 24168209 Am J Respir Crit Care Med 2013 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/24168209
Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB Jr, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ Science (New York, N.Y.) 26823428 Science 2016 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/26823428
Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Meyerholz DK, Lambertz AM, Reznikov LR, Ofori-Amanfo GK, Karp PH, McCray PB Jr, Welsh MJ, Stoltz DA Toxicologic pathology 26511846 Toxicol Pathol 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26511846
CF airway smooth muscle transcriptome reveals a role for PYK2. Cook DP, Adam RJ, Zarei K, Deonovic B, Stroik MR, Gansemer ND, Meyerholz DK, Au KF, Stoltz DA JCI insight 28878137 JCI Insight 2017 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/28878137
Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility. Cook DP, Rector MV, Bouzek DC, Michalski AS, Gansemer ND, Reznikov LR, Li X, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow CY, Stoltz DA American journal of respiratory and critical care medicine 26488271 Am J Respir Crit Care Med 2016 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/26488271
Acidic pH increases airway surface liquid viscosity in cystic fibrosis. Tang XX, Ostedgaard LS, Hoegger MJ, Moninger TO, Karp PH, McMenimen JD, Choudhury B, Varki A, Stoltz DA, Welsh MJ The Journal of clinical investigation 26808501 J Clin Invest 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26808501
Origins of cystic fibrosis lung disease. Stoltz DA, Meyerholz DK, Welsh MJ The New England journal of medicine 25607428 N Engl J Med 2015 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/25607428
Single-cell resolution of morphological changes in hemogenic endothelium. Bos FL, Hawkins JS, Zovein AC Development (Cambridge, England) 26243871 Development 2015 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/26243871
Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium. Zape JP, Lizama CO, Cautivo KM, Zovein AC Cell cycle (Georgetown, Tex.) 28820341 Cell Cycle 2017 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/28820341
Polarizing pathways: balancing endothelial polarity, permeability, and lumen formation. Lizama CO, Zovein AC Experimental cell research 23567183 Exp Cell Res 2013 May 15 https://www.ncbi.nlm.nih.gov/pubmed/23567183
Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Cautivo KM, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein AC Nature communications 26204127 Nat Commun 2015 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/26204127
Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A Nature communications 28743859 Nat Commun 2017 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/28743859
Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart. Ma XR, Conley SD, Kosicki M, Bredikhin D, Cui R, Tran S, Sheth MU, Qiu WL, Chen S, Kundu S, Kang HY, Amgalan D, Munger CJ, Duan L, Dang K, Rubio OM, Kany S, Zamirpour S, DePaolo J, Padmanabhan A, Birth Defects Research Laboratory, Olgin J, Damrauer S, Andersson R, Gu M, Priest JR, Quertermous T, Qiu X, Rabinovitch M, Visel A, Pennacchio L, Kundaje A, Glass IA, Gifford CA, Pirruccello JP, Goodyer WR, Engreitz JM medRxiv : the preprint server for health sciences 39606363 medRxiv 2024 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/39606363
Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens. Xu Z, Sziraki A, Lee J, Zhou W, Cao J Nature biotechnology 37749268 Nat Biotechnol 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/37749268
Optics-free Spatial Genomics for Mapping Mouse Brain Aging. Abdulraouf A, Jiang W, Xu Z, Zhang Z, Isakov S, Raihan T, Zhou W, Cao J bioRxiv : the preprint server for biology 39149282 bioRxiv 2024 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/39149282
Single-cell, whole-embryo phenotyping of mammalian developmental disorders. Huang X, Henck J, Qiu C, Sreenivasan VKA, Balachandran S, Amarie OV, Hrabě de Angelis M, Behncke RY, Chan WL, Despang A, Dickel DE, Duran M, Feuchtinger A, Fuchs H, Gailus-Durner V, Haag N, Hägerling R, Hansmeier N, Hennig F, Marshall C, Rajderkar S, Ringel A, Robson M, Saunders LM, da Silva-Buttkus P, Spielmann N, Srivatsan SR, Ulferts S, Wittler L, Zhu Y, Kalscheuer VM, Ibrahim DM, Kurth I, Kornak U, Visel A, Pennacchio LA, Beier DR, Trapnell C, Cao J, Shendure J, Spielmann M Nature 37968388 Nature 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37968388
Tracking cell-type-specific temporal dynamics in human and mouse brains. Lu Z, Zhang M, Lee J, Sziraki A, Anderson S, Zhang Z, Xu Z, Jiang W, Ge S, Nelson PT, Zhou W, Cao J Cell 37774676 Cell 2023 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/37774676
A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains. Sziraki A, Lu Z, Lee J, Banyai G, Anderson S, Abdulraouf A, Metzner E, Liao A, Banfelder J, Epstein A, Schaefer C, Xu Z, Zhang Z, Gan L, Nelson PT, Zhou W, Cao J Nature genetics 38036784 Nat Genet 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/38036784
A Panoramic View of Cell Population Dynamics in Mammalian Aging. Zhang Z, Schaefer C, Jiang W, Lu Z, Lee J, Sziraki A, Abdulraouf A, Wick B, Haeussler M, Li Z, Molla G, Satija R, Zhou W, Cao J bioRxiv : the preprint server for biology 38496474 bioRxiv 2024 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/38496474
A panoramic view of cell population dynamics in mammalian aging. Zhang Z, Schaefer C, Jiang W, Lu Z, Lee J, Sziraki A, Abdulraouf A, Wick B, Haeussler M, Li Z, Molla G, Satija R, Zhou W, Cao J Science (New York, N.Y.) 39607904 Science 2025 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/39607904
Organism-wide cellular dynamics and epigenomic remodeling in mammalian aging. Lu Z, Zhang Z, Xu Z, Abdulraouf A, Zhou W, Cao J bioRxiv : the preprint server for biology 40463164 bioRxiv 2025 May 15 https://www.ncbi.nlm.nih.gov/pubmed/40463164
Early peanut introduction wins over the HLA-DQA1*01:02 allele in the interplay between environment and genetics. Manohar M, Nadeau KC, Kasowski M The Journal of clinical investigation 34981779 J Clin Invest 2022 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/34981779
Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia. Wang XQD, Fan D, Han Q, Liu Y, Miao H, Wang X, Li Q, Chen D, Gore H, Himadewi P, Pfeifer GP, Cierpicki T, Grembecka J, Su J, Chong S, Wan L, Zhang X Cancer discovery 36455589 Cancer Discov 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36455589
Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Song L, Yao X, Li H, Peng B, Boka AP, Liu Y, Chen G, Liu Z, Mathias KM, Xia L, Li Q, Mir M, Li Y, Li H, Wan L Molecular cell 36272410 Mol Cell 2022 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/36272410
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia. Liu Y, Li Q, Alikarami F, Barrett DR, Mahdavi L, Li H, Tang S, Khan TA, Michino M, Hill C, Song L, Yang L, Li Y, Pokharel SP, Stamford AW, Liverton N, Renzetti LM, Taylor S, Watt GF, Ladduwahetty T, Kargman S, Meinke PT, Foley MA, Shi J, Li H, Carroll M, Chen CW, Gardini A, Maillard I, Huggins DJ, Bernt KM, Wan L Cancer discovery 36053276 Cancer Discov 2022 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/36053276
DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance. Zhou N, Choi J, Grothusen G, Kim BJ, Ren D, Cao Z, Liu Y, Li Q, Inamdar A, Beer T, Tang HY, Perkey E, Maillard I, Bonasio R, Shi J, Ruella M, Wan L, Busino L Blood 37235754 Blood 2023 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/37235754
Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions. Mathias KM, Liu Y, Wan L Current opinion in genetics & development 38788489 Curr Opin Genet Dev 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38788489
Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape. Song L, Li Q, Xia L, Sahay AE, Qiu Q, Li Y, Li H, Sasaki K, Susztak K, Wu H, Wan L Nature communications 39009564 Nat Commun 2024 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/39009564
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression. Liu Y, Li Q, Song L, Gong C, Tang S, Budinich KA, Vanderbeck A, Mathias KM, Wertheim GB, Nguyen SC, Outen R, Joyce EF, Maillard I, Wan L Cancer discovery 38655899 Cancer Discov 2024 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/38655899
HMGB1 restores a dynamic chromatin environment in the presence of linker histone by deforming nucleosomal DNA. Saunders HS, Chio US, Moore CM, Ramani V, Cheng Y, Narlikar GJ bioRxiv : the preprint server for biology 39229246 bioRxiv 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39229246
A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies. Freie B, Carroll PA, Varnum-Finney BJ, Ramani V, Bernstein I, Eisenman RN bioRxiv : the preprint server for biology 37961183 bioRxiv 2023 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/37961183
Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. Nanda AS, Wu K, Irkliyenko I, Woo B, Ostrowski MS, Clugston AS, Sayles LC, Xu L, Satpathy AT, Nguyen HG, Alejandro Sweet-Cordero E, Goodarzi H, Kasinathan S, Ramani V Nature genetics 38724748 Nat Genet 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38724748
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies. Freie B, Carroll PA, Varnum-Finney BJ, Ramsey EL, Ramani V, Bernstein I, Eisenman RN Genes & development 38565249 Genes Dev 2024 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/38565249
Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers. Yang MG, Richter HJ, Wang S, McNally CP, Harris N, Dhillon S, Maresca M, de Wit E, Willenbring H, Maher J, Goodarzi H, Ramani V bioRxiv : the preprint server for biology 39896524 bioRxiv 2025 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/39896524
Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Abdulhay NJ, Hsieh LJ, McNally CP, Ostrowski MS, Moore CM, Ketavarapu M, Kasinathan S, Nanda AS, Wu K, Chio US, Zhou Z, Goodarzi H, Narlikar GJ, Ramani V Nature structural & molecular biology 37696956 Nat Struct Mol Biol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37696956
ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers. Moore C, Wong E, Kaur U, Chio US, Zhou Z, Ostrowski M, Wu K, Irkliyenko I, Wang S, Ramani V, Narlikar GJ bioRxiv : the preprint server for biology 39314305 bioRxiv 2024 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/39314305
The single-molecule accessibility landscape of newly replicated mammalian chromatin. Ostrowski MS, Yang MG, McNally CP, Abdulhay NJ, Wang S, Renduchintala K, Irkliyenko I, Biran A, Chew BTL, Midha AD, Wong EV, Sandoval J, Jain IH, Groth A, Nora EP, Goodarzi H, Ramani V Cell 39549698 Cell 2025 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/39549698
Alternative mRNA splicing events and regulators in epidermal differentiation. Takashima S, Sun W, Otten ABC, Cai P, Peng SI, Tong E, Bui J, Mai M, Amarbayar O, Cheng B, Odango RJ, Li Z, Qu K, Sun BK Cell reports 38402585 Cell Rep 2024 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/38402585
The role of enhancers in psoriasis and atopic dermatitis. Sui JY, Eichenfield DZ, Sun BK The British journal of dermatology 37658835 Br J Dermatol 2023 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/37658835
The Long Noncoding RNA PRANCR Is Associated with Alternative Splicing of Fibronectin-1 in Keratinocytes. Otten ABC, Amarbayar O, Cai P, Cheng B, Qu K, Sun BK The Journal of investigative dermatology 36906126 J Invest Dermatol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/36906126
Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases. Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH Nature biotechnology 36991112 Nat Biotechnol 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/36991112
Bacterial genome engineering using CRISPR-associated transposases. Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang HH, Sternberg SH Nature protocols 38216671 Nat Protoc 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38216671
Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Meers C, Le HC, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Tang S, Sternberg SH Nature 37758954 Nature 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37758954
Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons. Klompe SE, Jaber N, Beh LY, Mohabir JT, Bernheim A, Sternberg SH Molecular cell 35051352 Mol Cell 2022 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/35051352
Transposon mutagenesis libraries reveal novel molecular requirements during CRISPR RNA-guided DNA integration. Walker MWG, Klompe SE, Zhang DJ, Sternberg SH bioRxiv : the preprint server for biology 36711804 bioRxiv 2023 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/36711804
Selective TnsC recruitment enhances the fidelity of RNA-guided transposition. Hoffmann FT, Kim M, Beh LY, Wang J, Vo PLH, Gelsinger DR, George JT, Acree C, Mohabir JT, Fernández IS, Sternberg SH Nature 36002573 Nature 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36002573
Novel molecular requirements for CRISPR RNA-guided transposition. Walker MWG, Klompe SE, Zhang DJ, Sternberg SH Nucleic acids research 37078593 Nucleic Acids Res 2023 May 22 https://www.ncbi.nlm.nih.gov/pubmed/37078593
Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases. Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH bioRxiv : the preprint server for biology 36993517 bioRxiv 2023 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/36993517
Genome editing with retroelements. Tang S, Sternberg SH Science (New York, N.Y.) 37883564 Science 2023 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/37883564
Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C, Park JU, Kong M, Wiegand T, Pignot YL, Kellogg EH, Greene EC, Sternberg SH bioRxiv : the preprint server for biology 37503092 bioRxiv 2023 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/37503092
TnpB homologues exapted from transposons are RNA-guided transcription factors. Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH Nature 38926585 Nature 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38926585
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH Nature microbiology 39747689 Nat Microbiol 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39747689
Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells. Lampe GD, Liang AR, Zhang DJ, Fernández IS, Sternberg SH bioRxiv : the preprint server for biology 39345383 bioRxiv 2024 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/39345383
Antagonistic conflict between transposon-encoded introns and guide RNAs. Žedaveinytė R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH Science (New York, N.Y.) 38991068 Science 2024 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/38991068
Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing. Vo PLH, Acree C, Smith ML, Sternberg SH Mobile DNA 34103093 Mob DNA 2021 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/34103093
Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C, Park JU, Kong M, Wiegand T, Pignot YL, Kellogg EH, Greene EC, Sternberg SH Science (New York, N.Y.) 37972161 Science 2023 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/37972161
Bacterial genome engineering using CRISPR RNA-guided transposases. Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang H, Sternberg SH bioRxiv : the preprint server for biology 36993567 bioRxiv 2023 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/36993567
Novel recombinases for large DNA insertions. Lampe GD, Sternberg SH Nature biotechnology 36424492 Nat Biotechnol 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36424492
De novo gene synthesis by an antiviral reverse transcriptase. Tang S, Conte V, Zhang DJ, Žedaveinytė R, Lampe GD, Wiegand T, Tang LC, Wang M, Walker MWG, George JT, Berchowitz LE, Jovanovic M, Sternberg SH Science (New York, N.Y.) 39116258 Science 2024 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/39116258
Harnessing the power of directed evolution to improve genome editing systems. Su Q, Zhou M, Cheng C, Niu J Current opinion in chemical biology 33725650 Curr Opin Chem Biol 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/33725650
"Click handle"-modified 2'-deoxy-2'-fluoroarabino nucleic acid as a synthetic genetic polymer capable of post-polymerization functionalization. Wu KB, Skrodzki CJA, Su Q, Lin J, Niu J Chemical science 35774169 Chem Sci 2022 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/35774169
Heparan sulfate glycomimetics via iterative assembly of "clickable" disaccharides. Yang C, Deng Y, Wang Y, Xia C, Mehta AY, Baker KJ, Samal A, Booneimsri P, Lertmaneedang C, Hwang S, Flynn JP, Cao M, Liu C, Zhu AC, Cummings RD, Lin C, Mohanty U, Niu J Chemical science 37006675 Chem Sci 2023 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/37006675
A General Approach to O-Sulfation by a Sulfur(VI) Fluoride Exchange Reaction. Liu C, Yang C, Hwang S, Ferraro SL, Flynn JP, Niu J Angewandte Chemie (International ed. in English) 32644280 Angew Chem Int Ed Engl 2020 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/32644280
Genome editor-directed in vivo library diversification. Cheng C, Zhou M, Su Q, Steigmeyer A, Niu J Cell chemical biology 34107297 Cell Chem Biol 2021 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/34107297
Fluorosulfate as a Latent Sulfate in Peptides and Proteins. Liu C, Liu X, Zhou M, Xia C, Lyu Y, Peng Q, Soni C, Zhou Z, Su Q, Wu Y, Weerapana E, Gao J, Chatterjee A, Lin C, Niu J Journal of the American Chemical Society 37647087 J Am Chem Soc 2023 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/37647087
Geared Toward Applications: A Perspective on Functional Sequence-Controlled Polymers. Yang C, Wu KB, Deng Y, Yuan J, Niu J ACS macro letters 34336395 ACS Macro Lett 2021 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/34336395
Cooperative DNA looping by PRC2 complexes. Lin X, Leicher R, Liu S, Zhang B Nucleic acids research 34057467 Nucleic Acids Res 2021 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/34057467
Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination. Wang L, Watters JW, Ju X, Lu G, Liu S Molecular cell 36917983 Mol Cell 2023 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/36917983
Optical tweezers in single-molecule biophysics. Bustamante CJ, Chemla YR, Liu S, Wang MD Nature reviews. Methods primers 34849486 Nat Rev Methods Primers 2021 https://www.ncbi.nlm.nih.gov/pubmed/34849486
Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA. Nguyen T, Li S, Chang JT, Watters JW, Ng H, Osunsade A, David Y, Liu S Nature communications 35810158 Nat Commun 2022 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/35810158
The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates. Mickolajczyk KJ, Olinares PDB, Chait BT, Liu S, Kapoor TM eLife 35147499 Elife 2022 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/35147499
Nonreciprocal and Conditional Cooperativity Directs the Pioneer Activity of Pluripotency Transcription Factors. Li S, Zheng EB, Zhao L, Liu S Cell reports 31484078 Cell Rep 2019 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/31484078
Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses. Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S eLife 32458799 Elife 2020 May 27 https://www.ncbi.nlm.nih.gov/pubmed/32458799
Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Leicher R, Ge EJ, Lin X, Reynolds MJ, Xie W, Walz T, Zhang B, Muir TW, Liu S Proceedings of the National Academy of Sciences of the United States of America 33208532 Proc Natl Acad Sci U S A 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/33208532
Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome. Ju X, Li S, Froom R, Wang L, Lilic M, Delbeau M, Campbell EA, Rock JM, Liu S Nature 38418874 Nature 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38418874
Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA. Chua GNL, Watters JW, Olinares PDB, Begum M, Vostal LE, Luo JA, Chait BT, Liu S Nature structural & molecular biology 39164525 Nat Struct Mol Biol 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39164525
A Tour de Force on the Double Helix: Exploiting DNA Mechanics To Study DNA-Based Molecular Machines. Wasserman MR, Liu S Biochemistry 31251042 Biochemistry 2019 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/31251042
Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase. Mickolajczyk KJ, Shelton PMM, Grasso M, Cao X, Warrington SE, Aher A, Liu S, Kapoor TM Biophysical journal 33340543 Biophys J 2021 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/33340543
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. Abini-Agbomson S, Gretarsson K, Shih RM, Hsieh L, Lou T, De Ioannes P, Vasilyev N, Lee R, Wang M, Simon MD, Armache JP, Nudler E, Narlikar G, Liu S, Lu C, Armache KJ Molecular cell 37595555 Mol Cell 2023 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/37595555
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Nucleosome-directed replication origin licensing independent of a consensus DNA sequence. Li S, Wasserman MR, Yurieva O, Bai L, O'Donnell ME, Liu S Nature communications 35999198 Nat Commun 2022 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/35999198
Probing the Interaction Between Chromatin and Chromatin-Associated Complexes with Optical Tweezers. Leicher R, Liu S Methods in molecular biology (Clifton, N.J.) 36063325 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/36063325
Origin recognition complex harbors an intrinsic nucleosome remodeling activity. Li S, Wasserman MR, Yurieva O, Bai L, O'Donnell ME, Liu S Proceedings of the National Academy of Sciences of the United States of America 36215487 Proc Natl Acad Sci U S A 2022 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/36215487
Differential dynamics specify MeCP2 function at methylated DNA and nucleosomes. Chua GNL, Watters JW, Olinares PDB, Luo JA, Chait BT, Liu S bioRxiv : the preprint server for biology 37333354 bioRxiv 2023 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/37333354
Structure and DNA bridging activity of the essential Rec114â€"Mei4 trimer interface. Liu K, Grasso EM, Pu S, Liu S, Eliezer D, Keeney S bioRxiv : the preprint server for biology 36711595 bioRxiv 2023 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/36711595
Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface. Liu K, Grasso EM, Pu S, Zou M, Liu S, Eliezer D, Keeney S Genes & development 37442580 Genes Dev 2023 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/37442580
Full-length RNA profiling reveals pervasive bidirectional transcription terminators in bacteria. Ju X, Li D, Liu S Nature microbiology 31308523 Nat Microbiol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31308523
Molecular mechanism for direct actin force-sensing by α-catenin. Mei L, Espinosa de Los Reyes S, Reynolds MJ, Leicher R, Liu S, Alushin GM eLife 32969337 Elife 2020 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/32969337
Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase. Wasserman MR, Schauer GD, O'Donnell ME, Liu S Cell 31348887 Cell 2019 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/31348887
Single-stranded nucleic acid binding and coacervation by linker histone H1. Leicher R, Osunsade A, Chua GNL, Faulkner SC, Latham AP, Watters JW, Nguyen T, Beckwitt EC, Christodoulou-Rubalcava S, Young PG, Zhang B, David Y, Liu S Nature structural & molecular biology 35484234 Nat Struct Mol Biol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35484234
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE Cell 33147445 Cell 2021 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/33147445
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome. Montalbano A, Canver MC, Sanjana NE Molecular cell 28985510 Mol Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28985510
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens. Liscovitch-Brauer N, Montalbano A, Deng J, Méndez-Mancilla A, Wessels HH, Moss NG, Kung CY, Sookdeo A, Guo X, Geller E, Jaini S, Smibert P, Sanjana NE Nature biotechnology 33927415 Nat Biotechnol 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/33927415
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Kasela S, Daniloski Z, Jordan TX, tenOever BR, Sanjana NE, Lappalainen T medRxiv : the preprint server for health sciences 33880488 medRxiv 2021 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/33880488
Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy. Lek A, Zhang Y, Woodman KG, Huang S, DeSimone AM, Cohen J, Ho V, Conner J, Mead L, Kodani A, Pakula A, Sanjana N, King OD, Jones PL, Wagner KR, Lek M, Kunkel LM Science translational medicine 32213627 Sci Transl Med 2020 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/32213627
Expanding the Scope of Bacterial CRISPR Activation with PAM-Flexible dCas9 Variants. Kiattisewee C, Karanjia AV, Legut M, Daniloski Z, Koplik SE, Nelson J, Kleinstiver BP, Sanjana NE, Carothers JM, Zalatan JG ACS synthetic biology 36378874 ACS Synth Biol 2022 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/36378874
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H Proceedings of the National Academy of Sciences of the United States of America 38743625 Proc Natl Acad Sci U S A 2024 May 21 https://www.ncbi.nlm.nih.gov/pubmed/38743625
Recurrent somatic mutations as predictors of immunotherapy response. Gajic ZZ, Deshpande A, Legut M, Imieliński M, Sanjana NE Nature communications 35803911 Nat Commun 2022 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/35803911
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. Garipler G, Lu C, Morrissey A, Lopez-Zepeda LS, Pei Y, Vidal SE, Zen Petisco Fiore AP, Aydin B, Stadtfeld M, Ohler U, Mahony S, Sanjana NE, Mazzoni EO Cell reports 35294876 Cell Rep 2022 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/35294876
Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. Lu C, Shi X, Allen A, Baez-Nieto D, Nikish A, Sanjana NE, Pan JQ FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30698461 FASEB J 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30698461
High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation. Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE Cell reports 32130891 Cell Rep 2020 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/32130891
GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease. Li L, Tian E, Chen X, Chao J, Klein J, Qu Q, Sun G, Sun G, Huang Y, Warden CD, Ye P, Feng L, Li X, Cui Q, Sultan A, Douvaras P, Fossati V, Sanjana NE, Riggs AD, Shi Y Cell stem cell 30075130 Cell Stem Cell 2018 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/30075130
A genome-wide net to catch and understand cancer. Sanjana NE Science translational medicine 30089637 Sci Transl Med 2018 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/30089637
Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens. Morris JA, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, Davis K, Ziosi M, Glinos DA, Hao S, Mimitou EP, Smibert P, Roeder K, Katsevich E, Lappalainen T, Sanjana NE Science (New York, N.Y.) 37141313 Science 2023 May 19 https://www.ncbi.nlm.nih.gov/pubmed/37141313
Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction. Shi X, Lu C, Corman A, Nikish A, Zhou Y, Platt RJ, Iossifov I, Zhang F, Pan JQ, Sanjana NE American journal of human genetics 37802044 Am J Hum Genet 2023 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/37802044
Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition. Wei W, Geer MJ, Guo X, Dolgalev I, Sanjana NE, Neel BG The Journal of experimental medicine 36820830 J Exp Med 2023 May 1 https://www.ncbi.nlm.nih.gov/pubmed/36820830
Essential transcription factors for induced neuron differentiation. Lu C, Garipler G, Dai C, Roush T, Salome-Correa J, Martin A, Liscovitch-Brauer N, Mazzoni EO, Sanjana NE Nature communications 38102126 Nat Commun 2023 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/38102126
Prediction of on-target and off-target activity of CRISPR-Cas13d guide RNAs using deep learning. Wessels HH, Stirn A, Méndez-Mancilla A, Kim EJ, Hart SK, Knowles DA, Sanjana NE Nature biotechnology 37400521 Nat Biotechnol 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/37400521
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox. Schertzer MD, Stirn A, Isaev K, Pereira L, Das A, Harbison C, Park SH, Wessels HH, Sanjana NE, Knowles DA bioRxiv : the preprint server for biology 37745416 bioRxiv 2023 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/37745416
Next-generation forward genetic screens: uniting high-throughput perturbations with single-cell analysis. Morris JA, Sun JS, Sanjana NE Trends in genetics : TIG 37989654 Trends Genet 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37989654
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling. Yan RE, Corman A, Katgara L, Wang X, Xue X, Gajic ZZ, Sam R, Farid M, Friedman SM, Choo J, Raimondi I, Ganesan S, Katsevich E, Greenfield JP, Dahmane N, Sanjana NE Nature biotechnology 39572737 Nat Biotechnol 2024 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/39572737
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types. Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE eLife 33570490 Elife 2021 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/33570490
Massively parallel Cas13 screens reveal principles for guide RNA design. Wessels HH, Méndez-Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana NE Nature biotechnology 32518401 Nat Biotechnol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32518401
Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells. Mimitou EP, Cheng A, Montalbano A, Hao S, Stoeckius M, Legut M, Roush T, Herrera A, Papalexi E, Ouyang Z, Satija R, Sanjana NE, Koralov SB, Smibert P Nature methods 31011186 Nat Methods 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31011186
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, Dhingra P, Wong EWP, Chi P, Apostolou E, Sanjana NE, Khurana E Cell systems 31078526 Cell Syst 2019 May 22 https://www.ncbi.nlm.nih.gov/pubmed/31078526
A genome-scale screen for synthetic drivers of T cell proliferation. Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman JA, Xue X, Lu C, Lu L, Mimitou EP, Hao S, Davoli T, Diefenbach C, Smibert P, Sanjana NE Nature 35296855 Nature 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35296855
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells. Méndez-Mancilla A, Wessels HH, Legut M, Kadina A, Mabuchi M, Walker J, Robb GB, Holden K, Sanjana NE Cell chemical biology 34343484 Cell Chem Biol 2022 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/34343484
Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq. Wessels HH, Méndez-Mancilla A, Hao Y, Papalexi E, Mauck WM 3rd, Lu L, Morris JA, Mimitou EP, Smibert P, Sanjana NE, Satija R Nature methods 36550277 Nat Methods 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36550277
Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens. Guo X, Rahman JA, Wessels HH, Méndez-Mancilla A, Haro D, Chen X, Sanjana NE Cell genomics 35664829 Cell Genom 2021 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/35664829
Cancer genes disfavoring T cell immunity identified via integrated systems approach. Kishton RJ, Patel SJ, Decker AE, Vodnala SK, Cam M, Yamamoto TN, Patel Y, Sukumar M, Yu Z, Ji M, Henning AN, Gurusamy D, Palmer DC, Stefanescu RA, Girvin AT, Lo W, Pasetto A, Malekzadeh P, Deniger DC, Wood KC, Sanjana NE, Restifo NP Cell reports 35926468 Cell Rep 2022 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/35926468
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells. Liang WW, Müller S, Hart SK, Wessels HH, Méndez-Mancilla A, Sookdeo A, Choi O, Caragine CM, Corman A, Lu L, Kolumba O, Williams B, Sanjana NE Cell 39532094 Cell 2024 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/39532094
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers. Caragine CM, Le VT, Mustafa M, Diaz BJ, Morris JA, Müller S, Mendez-Mancilla A, Geller E, Liscovitch-Brauer N, Sanjana NE Nature communications 39948336 Nat Commun 2025 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/39948336
Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A). Lu C, Sanjana NE Stem cell research 31707212 Stem Cell Res 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31707212
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types. Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE bioRxiv : the preprint server for biology 32587969 bioRxiv 2020 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/32587969
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Kasela S, Daniloski Z, Bollepalli S, Jordan TX, tenOever BR, Sanjana NE, Lappalainen T Genome biology 34425859 Genome Biol 2021 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/34425859
Tracking cell lineages to improve research reproducibility. Zaaijer S, Groen SC, Sanjana NE Nature biotechnology 34012093 Nat Biotechnol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34012093
Non-linear transcriptional responses to gradual modulation of transcription factor dosage. Domingo J, Minaeva M, Morris JA, Ghatan S, Ziosi M, Sanjana NE, Lappalainen T bioRxiv : the preprint server for biology 38464330 bioRxiv 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/38464330
Precise RNA targeting with CRISPR-Cas13d. Hart SK, Müller S, Wessels HH, Méndez-Mancilla A, Drabavicius G, Choi O, Sanjana NE Nature biotechnology 39934271 Nat Biotechnol 2025 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/39934271
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. D Antonio M, Weghorn D, D Antonio-Chronowska A, Coulet F, Olson KM, DeBoever C, Drees F, Arias A, Alakus H, Richardson AL, Schwab RB, Farley EK, Sunyaev SR, Frazer KA Nature communications 28874753 Nat Commun 2017 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/28874753
A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. Zhang W, Bojorquez-Gomez A, Velez DO, Xu G, Sanchez KS, Shen JP, Chen K, Licon K, Melton C, Olson KM, Yu MK, Huang JK, Carter H, Farley EK, Snyder M, Fraley SI, Kreisberg JF, Ideker T Nature genetics 29610481 Nat Genet 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29610481
Functional genomic approaches to elucidate the role of enhancers during development. Ryan GE, Farley EK Wiley interdisciplinary reviews. Systems biology and medicine 31808313 Wiley Interdiscip Rev Syst Biol Med 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31808313
3D genomics across the tree of life reveals condensin II as a determinant of architecture type. Hoencamp C, Dudchenko O, Elbatsh AMO, Brahmachari S, Raaijmakers JA, van Schaik T, Sedeño Cacciatore Á, Contessoto VG, van Heesbeen RGHP, van den Broek B, Mhaskar AN, Teunissen H, St Hilaire BG, Weisz D, Omer AD, Pham M, Colaric Z, Yang Z, Rao SSP, Mitra N, Lui C, Yao W, Khan R, Moroz LL, Kohn A, St Leger J, Mena A, Holcroft K, Gambetta MC, Lim F, Farley E, Stein N, Haddad A, Chauss D, Mutlu AS, Wang MC, Young ND, Hildebrandt E, Cheng HH, Knight CJ, Burnham TLU, Hovel KA, Beel AJ, Mattei PJ, Kornberg RD, Warren WC, Cary G, Gómez-Skarmeta JL, Hinman V, Lindblad-Toh K, Di Palma F, Maeshima K, Multani AS, Pathak S, Nel-Themaat L, Behringer RR, Kaur P, Medema RH, van Steensel B, de Wit E, Onuchic JN, Di Pierro M, Lieberman Aiden E, Rowland BD Science (New York, N.Y.) 34045355 Science 2021 May 28 https://www.ncbi.nlm.nih.gov/pubmed/34045355
Enhancer grammar in development, evolution, and disease: dependencies and interplay. Jindal GA, Farley EK Developmental cell 33689769 Dev Cell 2021 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/33689769
Diverse logics and grammar encode notochord enhancers. Song BP, Ragsac MF, Tellez K, Jindal GA, Grudzien JL, Le SH, Farley EK Cell reports 36729834 Cell Rep 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/36729834
Predictive analyses of regulatory sequences with EUGENe. Klie A, Laub D, Talwar JV, Stites H, Jores T, Solvason JJ, Farley EK, Carter H Nature computational science 38177592 Nat Comput Sci 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/38177592
Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. DeBoever C, Li H, Jakubosky D, Benaglio P, Reyna J, Olson KM, Huang H, Biggs W, Sandoval E, D'Antonio M, Jepsen K, Matsui H, Arias A, Ren B, Nariai N, Smith EN, D'Antonio-Chronowska A, Farley EK, Frazer KA Cell stem cell 28388430 Cell Stem Cell 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28388430
Affinity-optimizing enhancer variants disrupt development. Lim F, Solvason JJ, Ryan GE, Le SH, Jindal GA, Steffen P, Jandu SK, Farley EK Nature 38233525 Nature 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38233525
Conserved enhancer logic controls the notochord expression of vertebrate Brachyury. Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A bioRxiv : the preprint server for biology 37131681 bioRxiv 2023 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/37131681
Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development. Jindal GA, Bantle AT, Solvason JJ, Grudzien JL, D'Antonio-Chronowska A, Lim F, Le SH, Song BP, Ragsac MF, Klie A, Larsen RO, Frazer KA, Farley EK Developmental cell 37848026 Dev Cell 2023 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/37848026
Conserved enhancers control notochord expression of vertebrate Brachyury. Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A Nature communications 37852970 Nat Commun 2023 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/37852970
A single-cell transcriptional roadmap for cardiopharyngeal fate diversification. Wang W, Niu X, Stuart T, Jullian E, Mauck WM 3rd, Kelly RG, Satija R, Christiaen L Nature cell biology 31160712 Nat Cell Biol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31160712
Comprehensive Integration of Single-Cell Data. Stuart T, Butler A, Hoffman P, Hafemeister C, Papalexi E, Mauck WM 3rd, Hao Y, Stoeckius M, Smibert P, Satija R Cell 31178118 Cell 2019 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/31178118
Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Konstantinides N, Kapuralin K, Fadil C, Barboza L, Satija R, Desplan C Cell 29909983 Cell 2018 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/29909983
Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing. Huang ZY, Luo ZY, Cai YR, Chou CH, Yao ML, Pei FX, Kraus VB, Zhou ZK Osteoarthritis and cartilage 34971754 Osteoarthritis Cartilage 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34971754
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. Stephenson W, Donlin LT, Butler A, Rozo C, Bracken B, Rashidfarrokhi A, Goodman SM, Ivashkiv LB, Bykerk VP, Orange DE, Darnell RB, Swerdlow HP, Satija R Nature communications 29476078 Nat Commun 2018 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/29476078
Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. Stoeckius M, Zheng S, Houck-Loomis B, Hao S, Yeung BZ, Mauck WM 3rd, Smibert P, Satija R Genome biology 30567574 Genome Biol 2018 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/30567574
Integrating single-cell transcriptomic data across different conditions, technologies, and species. Butler A, Hoffman P, Smibert P, Papalexi E, Satija R Nature biotechnology 29608179 Nat Biotechnol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29608179
Simultaneous epitope and transcriptome measurement in single cells. Stoeckius M, Hafemeister C, Stephenson W, Houck-Loomis B, Chattopadhyay PK, Swerdlow H, Satija R, Smibert P Nature methods 28759029 Nat Methods 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28759029
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Villani AC, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, Griesbeck M, Butler A, Zheng S, Lazo S, Jardine L, Dixon D, Stephenson E, Nilsson E, Grundberg I, McDonald D, Filby A, Li W, De Jager PL, Rozenblatt-Rosen O, Lane AA, Haniffa M, Regev A, Hacohen N Science (New York, N.Y.) 28428369 Science 2017 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/28428369
A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells. Velasco S, Ibrahim MM, Kakumanu A, Garipler G, Aydin B, Al-Sayegh MA, Hirsekorn A, Abdul-Rahman F, Satija R, Ohler U, Mahony S, Mazzoni EO Cell stem cell 27939218 Cell Stem Cell 2017 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/27939218
Toward a Common Coordinate Framework for the Human Body. Rood JE, Stuart T, Ghazanfar S, Biancalani T, Fisher E, Butler A, Hupalowska A, Gaffney L, Mauck W, Eraslan G, Marioni JC, Regev A, Satija R Cell 31835027 Cell 2019 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/31835027
Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens. Papalexi E, Mimitou EP, Butler AW, Foster S, Bracken B, Mauck WM 3rd, Wessels HH, Hao Y, Yeung BZ, Smibert P, Satija R Nature genetics 33649593 Nat Genet 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33649593
Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Hafemeister C, Satija R Genome biology 31870423 Genome Biol 2019 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/31870423
A Reproducibility Focused Meta-Analysis Method for Single-Cell Transcriptomic Case-Control Studies Uncovers Robust Differentially Expressed Genes. Nakatsuka N, Adler D, Jiang L, Hartman A, Cheng E, Klann E, Satija R bioRxiv : the preprint server for biology 39463993 bioRxiv 2025 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/39463993
Developmental diversification of cortical inhibitory interneurons. Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R, Jaglin X, Allaway K, Butler A, Fishell G, Satija R Nature 29513653 Nature 2018 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/29513653
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Emerging Consciousness at a Clinical Crossroads. Young MJ, Edlow BL AJOB neuroscience 33960885 AJOB Neurosci 2021 Apr-Sep https://www.ncbi.nlm.nih.gov/pubmed/33960885
Long-Term Recovery from Disordered Consciousness Associated with COVID-19. Fischer D, Edlow BL Neurocritical care 34642843 Neurocrit Care 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34642843
Risk factors for 2-year mortality in patients with prolonged disorders of consciousness: An international multicentre study. Estraneo A, Magliacano A, Fiorenza S, Formisano R, Grippo A, Angelakis E, Cassol H, Thibaut A, Gosseries O, Lamberti G, Noé E, Bagnato S, Edlow BL, Chatelle C, Lejeune N, Veeramuthu V, Bartolo M, Mattia D, Toppi J, Zasler N, Schnakers C, Trojano L European journal of neurology 34657359 Eur J Neurol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34657359
Joint super-resolution and synthesis of 1 mm isotropic MP-RAGE volumes from clinical MRI exams with scans of different orientation, resolution and contrast. Iglesias JE, Billot B, Balbastre Y, Tabari A, Conklin J, Gilberto González R, Alexander DC, Golland P, Edlow BL, Fischl B, Alzheimer’s Disease Neuroimaging Initiative NeuroImage 34048902 Neuroimage 2021 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/34048902
Dopaminergic modulation of human consciousness via default mode network connectivity. Edlow BL Proceedings of the National Academy of Sciences of the United States of America 34330840 Proc Natl Acad Sci U S A 2021 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/34330840
Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL Journal of the neurological sciences 33497950 J Neurol Sci 2021 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/33497950
Intact Brain Network Function in an Unresponsive Patient with COVID-19. Fischer D, Threlkeld ZD, Bodien YG, Kirsch JE, Huang SY, Schaefer PW, Rapalino O, Hochberg LR, Rosen BR, Edlow BL Annals of neurology 32613682 Ann Neurol 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32613682
Ascending arousal network connectivity during recovery from traumatic coma. Snider SB, Bodien YG, Frau-Pascual A, Bianciardi M, Foulkes AS, Edlow BL NeuroImage. Clinical 33395992 Neuroimage Clin 2020 https://www.ncbi.nlm.nih.gov/pubmed/33395992
Optimizing the accuracy of cortical volumetric analysis in traumatic brain injury. Diamond BR, Donald CLM, Frau-Pascual A, Snider SB, Fischl B, Dams-O'Connor K, Edlow BL MethodsX 32760659 MethodsX 2020 https://www.ncbi.nlm.nih.gov/pubmed/32760659
Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies. Edlow BL, Claassen J, Schiff ND, Greer DM Nature reviews. Neurology 33318675 Nat Rev Neurol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33318675
SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry. Iglesias JE, Billot B, Balbastre Y, Magdamo C, Arnold SE, Das S, Edlow BL, Alexander DC, Golland P, Fischl B Science advances 36724222 Sci Adv 2023 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/36724222
One-Year Outcomes in Disorders of Consciousness Associated with COVID-19. Fischer D, Edlow BL Neurocritical care 36324001 Neurocrit Care 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36324001
Correcting cardiorespiratory noise in resting-state functional MRI data acquired in critically ill patients. Chan ST, Sanders WR, Fischer D, Kirsch JE, Napadow V, Bodien YG, Edlow BL Brain communications 36382222 Brain Commun 2022 https://www.ncbi.nlm.nih.gov/pubmed/36382222
Increased task-relevant fMRI responsiveness in comatose cardiac arrest patients is associated with improved neurologic outcomes. Dhakal K, Rosenthal ES, Kulpanowski AM, Dodelson JA, Wang Z, Cudemus-Deseda G, Villien M, Edlow BL, Presciutti AM, Januzzi JL, Ning M, Taylor Kimberly W, Amorim E, Brandon Westover M, Copen WA, Schaefer PW, Giacino JT, Greer DM, Wu O Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37728641 J Cereb Blood Flow Metab 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37728641
Covert cortical processing: a diagnosis in search of a definition. Young MJ, Fecchio M, Bodien YG, Edlow BL Neuroscience of consciousness 38327828 Neurosci Conscious 2024 https://www.ncbi.nlm.nih.gov/pubmed/38327828
Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA Journal of neurology, neurosurgery, and psychiatry 36241423 J Neurol Neurosurg Psychiatry 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36241423
Characterizing coma in large vessel occlusion stroke. Young MJ, Awad A, Andreev A, Bonkhoff AK, Schirmer MD, Dmytriw AA, Vranic JE, Rabinov JD, Doron O, Stapleton CJ, Das AS, Edlow BL, Singhal AB, Rost NS, Patel AB, Regenhardt RW Journal of neurology 38366071 J Neurol 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38366071
Are disorders of consciousness 'dis'connection or 'dys'connection syndromes? Edlow BL, Massimini M Brain communications 38410155 Brain Commun 2023 https://www.ncbi.nlm.nih.gov/pubmed/38410155
A human brain network linked to restoration of consciousness after deep brain stimulation. Warren AEL, Raguž M, Friedrich H, Schaper FLWVJ, Tasserie J, Snider SB, Li J, Chua MMJ, Butenko K, Friedrich MU, Jha R, Iglesias JE, Carney PW, Fischer D, Fox MD, Boes AD, Edlow BL, Horn A, Chudy D, Rolston JD medRxiv : the preprint server for health sciences 39484242 medRxiv 2024 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/39484242
Cortical lesions and focal white matter injury are associated with attentional performance in chronic traumatic brain injury. Snider SB, Gilmore N, Freeman HJ, Maffei C, Atalay A, Kumar RG, Li LM, Shi H, Bodien YG, Mac Donald CL, Dams-O'Connor K, Edlow BL Brain communications 39926612 Brain Commun 2025 https://www.ncbi.nlm.nih.gov/pubmed/39926612
Early Seizures Are Predictive of Worse Health-Related Quality of Life at Follow-Up After Intracerebral Hemorrhage. Naidech AM, Weaver B, Maas M, Bleck TP, VanHaerents S, Schuele SU Critical care medicine 33729725 Crit Care Med 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/33729725
A state-space model for dynamic functional connectivity. Chakravarty S, Threlkeld ZD, Bodien YG, Edlow BL, Brown EN Conference record. Asilomar Conference on Signals, Systems & Computers 32801606 Conf Rec Asilomar Conf Signals Syst Comput 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/32801606
7 Tesla MRI of the ex vivo human brain at 100 micron resolution. Edlow BL, Mareyam A, Horn A, Polimeni JR, Witzel T, Tisdall MD, Augustinack JC, Stockmann JP, Diamond BR, Stevens A, Tirrell LS, Folkerth RD, Wald LL, Fischl B, van der Kouwe A Scientific data 31666530 Sci Data 2019 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/31666530
Prolonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia. Waldrop G, Safavynia SA, Barra ME, Agarwal S, Berlin DA, Boehme AK, Brodie D, Choi JM, Doyle K, Fins JJ, Ganglberger W, Hoffman K, Mittel AM, Roh D, Mukerji SS, Der Nigoghossian C, Park S, Schenck EJ, Salazar-Schicchi J, Shen Q, Sholle E, Velazquez AG, Walline MC, Westover MB, Brown EN, Victor J, Edlow BL, Schiff ND, Claassen J Annals of neurology 35254675 Ann Neurol 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35254675
What is a minimal clinically important difference for clinical trials in patients with disorders of consciousness? a novel probabilistic approach. Monti MM, Spivak NM, Edlow BL, Bodien YG PloS one 37616196 PLoS One 2023 https://www.ncbi.nlm.nih.gov/pubmed/37616196
Coma Prognostication After Acute Brain Injury: A Review. Fischer D, Edlow BL JAMA neurology 38436946 JAMA Neurol 2024 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/38436946
Cross-regional coordination of activity in the human brain during autobiographical self-referential processing. Stieger JR, Pinheiro-Chagas P, Fang Y, Li J, Lusk Z, Perry CM, Girn M, Contreras D, Chen Q, Huguenard JR, Spreng RN, Edlow BL, Wagner AD, Buch V, Parvizi J Proceedings of the National Academy of Sciences of the United States of America 39078679 Proc Natl Acad Sci U S A 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39078679
Measuring Consciousness in the Intensive Care Unit. Edlow BL, Fecchio M, Bodien YG, Comanducci A, Rosanova M, Casarotto S, Young MJ, Li J, Dougherty DD, Koch C, Tononi G, Massimini M, Boly M Neurocritical care 37029315 Neurocrit Care 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37029315
Defining the boundary between life and death: New insights from neuropathology. Edlow BL, Kinney HC Journal of neuropathology and experimental neurology 36519398 J Neuropathol Exp Neurol 2022 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/36519398
Predicting Long-Term Recovery of Consciousness in Prolonged Disorders of Consciousness Based on Coma Recovery Scale-Revised Subscores: Validation of a Machine Learning-Based Prognostic Index. Magliacano A, Liuzzi P, Formisano R, Grippo A, Angelakis E, Thibaut A, Gosseries O, Lamberti G, Noé E, Bagnato S, Edlow BL, Lejeune N, Veeramuthu V, Trojano L, Zasler N, Schnakers C, Bartolo M, Mannini A, Estraneo A, IBIA DoC-SIG Brain sciences 36672033 Brain Sci 2022 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/36672033
Feasibility and Validity of the Coma Recovery Scale-Revised for Accelerated Standardized Testing: A Practical Assessment Tool for Detecting Consciousness in the Intensive Care Unit. Bodien YG, Vora I, Barra A, Chiang K, Chatelle C, Goostrey K, Martens G, Malone C, Mello J, Parlman K, Ranford J, Sterling A, Waters AB, Hirschberg R, Katz DI, Mazwi N, Ni P, Velmahos G, Waak K, Edlow BL, Giacino JT Annals of neurology 37488068 Ann Neurol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37488068
Sustaining wakefulness: Brainstem connectivity in human consciousness. Edlow BL, Olchanyi M, Freeman HJ, Li J, Maffei C, Snider SB, Zöllei L, Iglesias JE, Augustinack J, Bodien YG, Haynes RL, Greve DN, Diamond BR, Stevens A, Giacino JT, Destrieux C, van der Kouwe A, Brown EN, Folkerth RD, Fischl B, Kinney HC bioRxiv : the preprint server for biology 37502983 bioRxiv 2023 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/37502983
Histology-guided MRI segmentation of brainstem nuclei critical to consciousness. Olchanyi MD, Augustinack J, Haynes RL, Lewis LD, Cicero N, Li J, Destrieux C, Folkerth RD, Kinney HC, Fischl B, Brown EN, Iglesias JE, Edlow BL medRxiv : the preprint server for health sciences 39399006 medRxiv 2024 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/39399006
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury. Kumar RG, Selmanovic E, Gilmore N, Spielman L, Li LM, Hoffman JM, Bodien YG, Snider SB, Freeman HJ, de Souza NL, Mac Donald CL, Edlow BL, Dams-O'Connor K Brain communications 40574978 Brain Commun 2025 https://www.ncbi.nlm.nih.gov/pubmed/40574978
Three-dimensional fiber orientation mapping of ex vivo human brain at micrometer resolution. Liu CJ, Ammon W, Jones RJ, Nolan JC, Gong D, Maffei C, Blanke N, Edlow BL, Augustinack JC, Magnain C, Yendiki A, Villiger M, Fischl B, Wang H Npj imaging.. 40213097 Npj Imaging 2025 https://www.ncbi.nlm.nih.gov/pubmed/40213097
Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness. Edlow BL, Olchanyi M, Freeman HJ, Li J, Maffei C, Snider SB, Zöllei L, Iglesias JE, Augustinack J, Bodien YG, Haynes RL, Greve DN, Diamond BR, Stevens A, Giacino JT, Destrieux C, van der Kouwe A, Brown EN, Folkerth RD, Fischl B, Kinney HC Science translational medicine 38691619 Sci Transl Med 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38691619
Cortical Lesion Expansion in Chronic Traumatic Brain Injury. Freeman HJ, Atalay AS, Li J, Sobczak E, Gilmore N, Snider SB, Healy BC, Carrington H, Selmanovic E, Pruyser A, Bura L, Sheppard D, Hunt D, Seifert AC, Bodien YG, Hoffman JM, Mac Donald CL, Dams-O'Connor K, Edlow BL medRxiv : the preprint server for health sciences 38978662 medRxiv 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/38978662
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury. Kumar RG, Selmanovic E, Gilmore N, Spielman L, Li LM, Hoffman JM, Bodien YG, Snider SB, Freeman HJ, de Souza NL, Donald CLM, Edlow BL, Dams-O'Connor K medRxiv : the preprint server for health sciences 39974133 medRxiv 2025 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/39974133
Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study. Coffey BJ, Threlkeld ZD, Foulkes AS, Bodien YG, Edlow BL Brain injury 34546806 Brain Inj 2021 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/34546806
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG Neurocritical care 32794142 Neurocrit Care 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32794142
Multicenter prospective study on predictors of short-term outcome in disorders of consciousness. Estraneo A, Fiorenza S, Magliacano A, Formisano R, Mattia D, Grippo A, Romoli AM, Angelakis E, Cassol H, Thibaut A, Gosseries O, Lamberti G, Noé E, Bagnato S, Edlow BL, Chatelle C, Lejeune N, Veeramuthu V, Bartolo M, Toppi J, Zasler N, Schnakers C, Trojano L, IBIA DoC-SIG Neurology 32661102 Neurology 2020 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/32661102
Unmasking Covert Language Processing in the Intensive Care Unit with Electroencephalography. Edlow BL, Naccache L Annals of neurology 33491250 Ann Neurol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33491250
Common Data Elements for COVID-19 Neuroimaging: A GCS-NeuroCOVID Proposal. Edlow BL, Boly M, Chou SH, Fischer D, Kondziella D, Li LM, Mac Donald CL, McNett M, Newcombe VFJ, Stevens RD, Menon DK, GCS-NeuroCOVID Neurocritical care 33575956 Neurocrit Care 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33575956
Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions. Edlow BL, Sanz LRD, Polizzotto L, Pouratian N, Rolston JD, Snider SB, Thibaut A, Stevens RD, Gosseries O, Curing Coma Campaign and its contributing members Neurocritical care 34236624 Neurocrit Care 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34236624
The neuroethics of disorders of consciousness: a brief history of evolving ideas. Young MJ, Bodien YG, Giacino JT, Fins JJ, Truog RD, Hochberg LR, Edlow BL Brain : a journal of neurology 34347037 Brain 2021 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/34347037
Location of Subcortical Microbleeds and Recovery of Consciousness After Severe Traumatic Brain Injury. Bianciardi M, Izzy S, Rosen BR, Wald LL, Edlow BL Neurology 34050005 Neurology 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/34050005
Update on neuroimaging in disorders of consciousness. Sanz LRD, Thibaut A, Edlow BL, Laureys S, Gosseries O Current opinion in neurology 34054109 Curr Opin Neurol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/34054109
Transcranial Pulsed-Current Stimulation versus Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Pilot, Sham-Controlled Cross-Over Double-Blind Study. Barra A, Rosenfelder M, Mortaheb S, Carrière M, Martens G, Bodien YG, Morales-Quezada L, Bender A, Laureys S, Thibaut A, Fregni F Brain sciences 35447961 Brain Sci 2022 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/35447961
The Quest for Covert Consciousness: Bringing Neuroethics to the Bedside. Young MJ, Edlow BL Neurology 33653901 Neurology 2021 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33653901
Recovery Potential in Patients Who Died After Withdrawal of Life-Sustaining Treatment: A TRACK-TBI Propensity Score Analysis. Sanders WR, Barber JK, Temkin NR, Foreman B, Giacino JT, Williamson T, Edlow BL, Manley GT, Bodien YG Journal of neurotrauma 38739032 J Neurotrauma 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38739032
Disclosing Results of Tests for Covert Consciousness: A Framework for Ethical Translation. Young MJ, Kazazian K, Fischer D, Lissak IA, Bodien YG, Edlow BL Neurocritical care 38243150 Neurocrit Care 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38243150
Common data elements for disorders of consciousness. Edlow BL, Claassen J, Suarez JI Neurocritical care 38291278 Neurocrit Care 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38291278
Severe cerebral edema in substance-related cardiac arrest patients. Kulpanowski AM, Copen WA, Hancock BL, Rosenthal ES, Schoenfeld DA, Dodelson JA, Edlow BL, Kimberly WT, Amorim E, Westover MB, Ning MM, Schaefer PW, Malhotra R, Giacino JT, Greer DM, Wu O Resuscitation 35149137 Resuscitation 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35149137
Toward Uniform Insurer Coverage for Functional MRI Following Severe Brain Injury. Young MJ, Bodien YG, Freeman HJ, Fecchio M, Edlow BL The Journal of head trauma rehabilitation 36854104 J Head Trauma Rehabil 2023 Jul-Aug 01 https://www.ncbi.nlm.nih.gov/pubmed/36854104
Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap. Schiff ND, Diringer M, Diserens K, Edlow BL, Gosseries O, Hill NJ, Hochberg LR, Ismail FY, Meyer IA, Mikell CB, Mofakham S, Molteni E, Polizzotto L, Shah SA, Stevens RD, Thengone D, and the Curing Coma Campaign and its Contributing Members Neurocritical care 38286946 Neurocrit Care 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38286946
Cognitive Motor Dissociation in Disorders of Consciousness. Bodien YG, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh JE, Kamau E, Lawrence PK, Lupson VC, Meydan A, Rohaut B, Sanders WR, Sitt JD, Soddu A, Valente M, Velazquez A, Voss HU, Vrosgou A, Claassen J, Edlow BL, Fins JJ, Gosseries O, Laureys S, Menon D, Naccache L, Owen AM, Pickard J, Stamatakis EA, Thibaut A, Victor JD, Giacino JT, Bagiella E, Schiff ND The New England journal of medicine 39141852 N Engl J Med 2024 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/39141852
Three-dimensional fiber orientation mapping of the human brain at micrometer resolution. Liu CJ, Ammon W, Jones RJ, Nolan JC, Gong D, Maffei C, Edlow BL, Augustinack JC, Magnain C, Yendiki A, Villiger M, Fischl B, Wang H Research square 39149445 Res Sq 2024 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/39149445
Automated Measurement of Cerebral Hemorrhagic Contusions and Outcomes After Traumatic Brain Injury in the TRACK-TBI Study. Snider SB, Temkin NR, Sun X, Stubbs JL, Rademaker QJ, Markowitz AJ, Rosenthal ES, Diaz-Arrastia R, Fox MD, Manley GT, Jain S, Edlow BL, TRACK-TBI Investigators JAMA network open 39212991 JAMA Netw Open 2024 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/39212991
The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology. Gleeson JP, Fein KC, Chaudhary N, Doerfler R, Newby AN, Whitehead KA International journal of pharmaceutics 33249250 Int J Pharm 2021 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/33249250
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. Melamed JR, Hajj KA, Chaudhary N, Strelkova D, Arral ML, Pardi N, Alameh MG, Miller JB, Farbiak L, Siegwart DJ, Weissman D, Whitehead KA Journal of controlled release : official journal of the Controlled Release Society 34801660 J Control Release 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34801660
The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism. Strelkova Petersen DM, Chaudhary N, Arral ML, Weiss RM, Whitehead KA European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 37838143 Eur J Pharm Biopharm 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37838143
Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes. Chaudhary N, Newby AN, Arral ML, Yerneni SS, LoPresti ST, Doerfler R, Petersen DMS, Montoya C, Kim JS, Fox B, Coon T, Malaney A, Sadovsky Y, Whitehead KA Proceedings of the National Academy of Sciences of the United States of America 38437545 Proc Natl Acad Sci U S A 2024 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/38437545
mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Chaudhary N, Weissman D, Whitehead KA Nature reviews. Drug discovery 34433919 Nat Rev Drug Discov 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34433919
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability. Lamson NG, Berger A, Fein KC, Whitehead KA Nature biomedical engineering 31686002 Nat Biomed Eng 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31686002
Placental drug transport and fetal exposure during pregnancy is determined by drug molecular size, chemistry, and conformation. Fein KC, Arral ML, Kim JS, Newby AN, Whitehead KA Journal of controlled release : official journal of the Controlled Release Society 37473809 J Control Release 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37473809
Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory control. Mokhtari T, Taheri MN, Akhlaghi S, Aryannejad A, Xiang Y, Mahajan V, Keshavarz K, Kiani A, LoPresti S, LeGraw R, Whitehead KA, Kiani S bioRxiv : the preprint server for biology 40060445 bioRxiv 2025 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/40060445
Oral delivery of peptide therapeutics in infants: Challenges and opportunities. Gleeson JP, Fein KC, Whitehead KA Advanced drug delivery reviews 33774115 Adv Drug Deliv Rev 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33774115
Non-Viral RNA Delivery During Pregnancy: Opportunities and Challenges. Chaudhary N, Newby AN, Whitehead KA Small (Weinheim an der Bergstrasse, Germany) 38145340 Small 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38145340
Characterization and comparison of human and mouse milk cells. Doerfler R, Yerneni S, Newby A, Chaudhary N, Shu A, Fein K, Hofstatter Azambuja J, Whitehead KA PloS one 38295101 PLoS One 2024 https://www.ncbi.nlm.nih.gov/pubmed/38295101
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs. LoPresti ST, Arral ML, Chaudhary N, Whitehead KA Journal of controlled release : official journal of the Controlled Release Society 35346768 J Control Release 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35346768
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer. Melamed JR, Yerneni SS, Arral ML, LoPresti ST, Chaudhary N, Sehrawat A, Muramatsu H, Alameh MG, Pardi N, Weissman D, Gittes GK, Whitehead KA Science advances 36706177 Sci Adv 2023 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/36706177
Profiling of mature-stage human breast milk cells identifies six unique lactocyte subpopulations. Gleeson JP, Chaudhary N, Fein KC, Doerfler R, Hredzak-Showalter P, Whitehead KA Science advances 35767604 Sci Adv 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35767604
The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery. Lamson NG, Fein KC, Gleeson JP, Newby AN, Xian S, Cochran K, Chaudhary N, Melamed JR, Ball RL, Suri K, Ahuja V, Zhang A, Berger A, Kolodieznyi D, Schmidt BF, Silva GL, Whitehead KA Proceedings of the National Academy of Sciences of the United States of America 35943988 Proc Natl Acad Sci U S A 2022 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/35943988
The Effect of Infant Gastric Digestion on Human Maternal Milk Cells. Doerfler R, Melamed JR, Whitehead KA Molecular nutrition & food research 35984112 Mol Nutr Food Res 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35984112
Branched-Tail Lipid Nanoparticles for Intravenous mRNA Delivery to Lung Immune, Endothelial, and Alveolar Cells in Mice. Petersen DMS, Weiss RM, Hajj KA, Yerneni SS, Chaudhary N, Newby AN, Arral ML, Whitehead KA Advanced healthcare materials 38888972 Adv Healthc Mater 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38888972
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d. Chaudhary N, Kasiewicz LN, Newby AN, Arral ML, Yerneni SS, Melamed JR, LoPresti ST, Fein KC, Strelkova Petersen DM, Kumar S, Purwar R, Whitehead KA Nature biomedical engineering 39363106 Nat Biomed Eng 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39363106
Maternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport. Doerfler R, Yerneni S, LoPresti S, Chaudhary N, Newby A, Melamed JR, Malaney A, Whitehead KA FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39835705 FASEB J 2025 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/39835705
The Latent Genetic Structure of Impulsivity and Its Relation to Internalizing Psychopathology. Gustavson DE, Friedman NP, Fontanillas P, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S Psychological science 32716714 Psychol Sci 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32716714
Medical phenome of musicians: an investigation of health records collected on 9803 musically active individuals. Niarchou M, Lin GT, Lense MD, Gordon RL, Davis LK Annals of the New York Academy of Sciences 34414577 Ann N Y Acad Sci 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34414577
Interprofessional education of the next generation of musician-scientists through music cognition research training: An innovative platform for health professions and biomedical research. Gordon RL, Lense MD Music and medicine 33603955 Music Med 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/33603955
Is atypical rhythm a risk factor for developmental speech and language disorders? Ladányi E, Persici V, Fiveash A, Tillmann B, Gordon RL Wiley interdisciplinary reviews. Cognitive science 32244259 Wiley Interdiscip Rev Cogn Sci 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32244259
Exploring individual differences in musical rhythm and grammar skills in school-aged children with typically developing language. Nitin R, Gustavson DE, Aaron AS, Boorom OA, Bush CT, Wiens N, Vaughan C, Persici V, Blain SD, Soman U, Hambrick DZ, Camarata SM, McAuley JD, Gordon RL Scientific reports 36750727 Sci Rep 2023 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/36750727
Processing rhythm in speech and music: Shared mechanisms and implications for developmental speech and language disorders. Fiveash A, Bedoin N, Gordon RL, Tillmann B Neuropsychology 34435803 Neuropsychology 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34435803
Heritability of Childhood Music Engagement and Associations with Language and Executive Function: Insights from the Adolescent Brain Cognitive Development (ABCD) Study. Gustavson DE, Nayak S, Coleman PL, Iversen JR, Lense MD, Gordon RL, Maes HH Behavior genetics 36757558 Behav Genet 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36757558
Musical instrument engagement in adolescence predicts verbal ability 4 years later: A twin and adoption study. Gustavson DE, Friedman NP, Stallings MC, Reynolds CA, Coon H, Corley RP, Hewitt JK, Gordon RL Developmental psychology 34914455 Dev Psychol 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34914455
Polygenic Associations between Motor Behaviour, Neuromotor Traits, and Active Music Engagement in Four Cohorts. Henechowicz TL, Coleman PL, Gustavson DE, Mekki YN, Nayak S, Nitin R, Scartozzi AC, Tio ES, van Klei R, Felsky D, Thaut MH, Gordon RL bioRxiv : the preprint server for biology 40196524 bioRxiv 2025 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/40196524
Rhythm and timing as vulnerabilities in neurodevelopmental disorders. Lense MD, Ladányi E, Rabinowitch TC, Trainor L, Gordon R Philosophical transactions of the Royal Society of London. Series B, Biological sciences 34420385 Philos Trans R Soc Lond B Biol Sci 2021 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/34420385
Pushing the Envelope: Developments in Neural Entrainment to Speech and the Biological Underpinnings of Prosody Perception. Myers BR, Lense MD, Gordon RL Brain sciences 30909454 Brain Sci 2019 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/30909454
Does rhythmic priming improve grammatical processing in Hungarian-speaking children with and without developmental language disorder? Ladányi E, Lukács Á, Gervain J Developmental science 34060171 Dev Sci 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34060171
Mental health and music engagement: review, framework, and guidelines for future studies. Gustavson DE, Coleman PL, Iversen JR, Maes HH, Gordon RL, Lense MD Translational psychiatry 34226495 Transl Psychiatry 2021 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/34226495
The case for treatment fidelity in active music interventions: why and how. Wiens N, Gordon RL Annals of the New York Academy of Sciences 29727027 Ann N Y Acad Sci 2018 May 4 https://www.ncbi.nlm.nih.gov/pubmed/29727027
Individual differences in neural markers of beat processing relate to spoken grammar skills in six-year-old children. Persici V, Blain SD, Iversen JR, Key AP, Kotz SA, Devin McAuley J, Gordon RL Brain and language 37994830 Brain Lang 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37994830
The shared genetic architecture and evolution of human language and musical rhythm. Alagöz G, Eising E, Mekki Y, Bignardi G, Fontanillas P, 23andMe Research Team, Nivard MG, Luciano M, Cox NJ, Fisher SE, Gordon RL Nature human behaviour 39572686 Nat Hum Behav 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39572686
New evidence of a rhythmic priming effect that enhances grammaticality judgments in children. Chern A, Tillmann B, Vaughan C, Gordon RL Journal of experimental child psychology 29778278 J Exp Child Psychol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/29778278
Elevated Polygenic Burden for Autism Spectrum Disorder Is Associated With the Broad Autism Phenotype in Mothers of Individuals With Autism Spectrum Disorder. Nayar K, Sealock JM, Maltman N, Bush L, Cook EH, Davis LK, Losh M Biological psychiatry 33229037 Biol Psychiatry 2021 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/33229037
Synaptic processes and immune-related pathways implicated in Tourette syndrome. Tsetsos F, Yu D, Sul JH, Huang AY, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau GA, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados MA, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Wagner M, Knowles JA, Jeremy Willsey A, Tischfield JA, Heiman GA, Cox NJ, Freimer NB, Neale BM, Davis LK, Coppola G, Mathews CA, Scharf JM, Paschou P, Tourette Association of America International Consortium for Genetics, Barr CL, Batterson JR, Berlin C, Budman CL, Cath DC, Coppola G, Cox NJ, Darrow S, Davis LK, Dion Y, Freimer NB, Grados MA, Greenberg E, Hirschtritt ME, Huang AY, Illmann C, King RA, Kurlan R, Leckman JF, Lyon GJ, Malaty IA, Mathews CA, McMahon WM, Neale BM, Okun MS, Osiecki L, Robertson MM, Rouleau GA, Sandor P, Scharf JM, Singer HS, Smit JH, Sul JH, Yu D, Gilles de la Tourette GWAS Replication Initiative, Aschauer HAH, Barta C, Budman CL, Cath DC, Depienne C, Hartmann A, Hebebrand J, Konstantinidis A, Mathews CA, Müller-Vahl K, Nagy P, Nöthen MM, Paschou P, Rizzo R, Rouleau GA, Sandor P, Scharf JM, Schlögelhofer M, Stamenkovic M, Stuhrmann M, Tsetsos F, Tarnok Z, Wolanczyk T, Worbe Y, Tourette International Collaborative Genetics Study, Brown L, Cheon KA, Coffey BJ, Dietrich A, Fernandez TV, Garcia-Delgar B, Gilbert D, Grice DE, Hagstrøm J, Hedderly T, Heiman GA, Heyman I, Hoekstra PJ, Huyser C, Kim YK, Kim YS, King RA, Koh YJ, Kook S, Kuperman S, Leventhal BL, Madruga-Garrido M, Mir P, Morer A, Münchau A, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Tischfield JA, Willsey AJ, Zinner S, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Aschauer H, Barr CL, Barta C, Batterson JR, Berlin C, Brown L, Budman CL, Cath DC, Coffey BJ, Coppola G, Cox NJ, Darrow S, Davis LK, Depienne C, Dietrich A, Dion Y, Fernandez T, Freimer NB, Gilbert D, Grados MA, Greenberg E, Hartmann A, Hebebrand J, Heiman G, Hirschtritt ME, Hoekstra P, Huang AY, Illmann C, Jankovic J, King RA, Kuperman S, Lee PC, Lyon GJ, Malaty IA, Mathews CA, McMahon WM, Müller-Vahl K, Nagy P, Neale BM, Nöthen MM, Okun MS, Osiecki L, Paschou P, Rizzo R, Robertson MM, Rouleau GA, Sandor P, Scharf JM, Schlögelhofer M, Singer HS, Stamenkovic M, Stuhrmann M, Sul JH, Tarnok Z, Tischfield J, Tsetsos F, Willsey AJ, Woods D, Worbe Y, Yu D, Zinner S Translational psychiatry 33462189 Transl Psychiatry 2021 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/33462189
Neurophysiological Correlates of Dynamic Beat Tracking in Individuals With Williams Syndrome. Kasdan A, Gordon RL, Lense MD Biological psychiatry. Cognitive neuroscience and neuroimaging 33419711 Biol Psychiatry Cogn Neurosci Neuroimaging 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/33419711
Linking the genomic signatures of human beat synchronization and learned song in birds. Gordon RL, Ravignani A, Hyland Bruno J, Robinson CM, Scartozzi A, Embalabala R, Niarchou M, 23andMe Research Team, Cox NJ, Creanza N Philosophical transactions of the Royal Society of London. Series B, Biological sciences 34420388 Philos Trans R Soc Lond B Biol Sci 2021 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/34420388
A neurodevelopmental disorders perspective into music, social attention, and social bonding. Kasdan A, Gordon RL, Lense MD The Behavioral and brain sciences 34588066 Behav Brain Sci 2021 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/34588066
Infants' neural speech discrimination predicts individual differences in grammar ability at 6 years of age and their risk of developing speech-language disorders. Zhao TC, Boorom O, Kuhl PK, Gordon R Developmental cognitive neuroscience 33823366 Dev Cogn Neurosci 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33823366
The shared genetic architecture and evolution of human language and musical rhythm. Alagöz G, Eising E, Mekki Y, Bignardi G, Fontanillas P, 23andMe Research Team, Nivard MG, Luciano M, Cox NJ, Fisher SE, Gordon RL bioRxiv : the preprint server for biology 37961248 bioRxiv 2023 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/37961248
Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study. Gustavson DE, Coleman PL, Wang Y, Nitin R, Petty LE, Bush CT, Mosing MA, Wesseldijk LW, Ullén F, 23 and Me Research Team, Below JE, Cox NJ, Gordon RL Annals of the New York Academy of Sciences 36718543 Ann N Y Acad Sci 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36718543
The Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) Framework for Understanding Musicality-Language Links Across the Lifespan. Nayak S, Coleman PL, Ladányi E, Nitin R, Gustavson DE, Fisher SE, Magne CL, Gordon RL Neurobiology of language (Cambridge, Mass.) 36742012 Neurobiol Lang (Camb) 2022 https://www.ncbi.nlm.nih.gov/pubmed/36742012
Regular rhythmic primes improve sentence repetition in children with developmental language disorder. Fiveash A, Ladányi E, Camici J, Chidiac K, Bush CT, Canette LH, Bedoin N, Gordon RL, Tillmann B NPJ science of learning 37429839 NPJ Sci Learn 2023 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/37429839
Genetic and Environmental Influences on Semantic Verbal Fluency Across Midlife and Later Life. Gustavson DE, Panizzon MS, Kremen WS, Reynolds CA, Pahlen S, Nygaard M, Wod M, Catts VS, Lee T, Gatz M, Franz CE, IGEMS Consortium Behavior genetics 33547998 Behav Genet 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33547998
Identifying a brain network for musical rhythm: A functional neuroimaging meta-analysis and systematic review. Kasdan AV, Burgess AN, Pizzagalli F, Scartozzi A, Chern A, Kotz SA, Wilson SM, Gordon RL Neuroscience and biobehavioral reviews 35259422 Neurosci Biobehav Rev 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35259422
You got rhythm, or more: The multidimensionality of rhythmic abilities. Fiveash A, Bella SD, Bigand E, Gordon RL, Tillmann B Attention, perception & psychophysics 35437703 Atten Percept Psychophys 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35437703
Using a polygenic score in a family design to understand genetic influences on musicality. Wesseldijk LW, Abdellaoui A, Gordon RL, 23andMe Research Team, Ullén F, Mosing MA Scientific reports 36038631 Sci Rep 2022 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/36038631
Confronting ethical and social issues related to the genetics of musicality. Gordon RL, Martschenko DO, Nayak S, Niarchou M, Morrison MD, Bell E, Jacoby N, Davis LK Annals of the New York Academy of Sciences 36851882 Ann N Y Acad Sci 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36851882
Genome-wide association study of musical beat synchronization demonstrates high polygenicity. Niarchou M, Gustavson DE, Sathirapongsasuti JF, Anglada-Tort M, Eising E, Bell E, McArthur E, Straub P, 23andMe Research Team, McAuley JD, Capra JA, Ullén F, Creanza N, Mosing MA, Hinds DA, Davis LK, Jacoby N, Gordon RL Nature human behaviour 35710621 Nat Hum Behav 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35710621
The Neural Correlates of Spontaneous Beat Processing and Its Relationship with Music-Related Characteristics of the Individual. Scartozzi AC, Wang Y, Bush CT, Kasdan AV, Fram NR, Woynaroski T, Lense MD, Gordon RL, Ladányi E eNeuro 39401929 eNeuro 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39401929
Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in Pseudomonas aeruginosa. Patteson JB, Lescallette AR, Li B Organic letters 31247735 Org Lett 2019 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/31247735
Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa. Patteson JB, Putz AT, Tao L, Simke WC, Bryant LH 3rd, Britt RD, Li B Science (New York, N.Y.) 34793213 Science 2021 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/34793213
Chemoproteomics Reveals Disruption of Metal Homeostasis and Metalloproteins by the Antibiotic Holomycin. Chan AN, Chen X, Falco JA, Bak DW, Weerapana E, Li B ACS chemical biology 37561838 ACS Chem Biol 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37561838
Pseudomonas virulence factor controls expression of virulence genes in Pseudomonas entomophila. Acken KA, Li B PloS one 37200397 PLoS One 2023 https://www.ncbi.nlm.nih.gov/pubmed/37200397
Analysis of Co-localized Biosynthetic Gene Clusters Identifies a Membrane-Permeabilizing Natural Product. Chen X, Li B Journal of natural products 38949271 J Nat Prod 2024 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/38949271
Specificity of Nonribosomal Peptide Synthetases in the Biosynthesis of the Pseudomonas virulence factor. Morgan GL, Kretsch AM, Santa Maria KC, Weeks SJ, Li B Biochemistry 31243997 Biochemistry 2019 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/31243997
Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase. Morgan GL, Li K, Crawford DM, Aubé J, Li B ACS chemical biology 34767712 ACS Chem Biol 2021 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/34767712
Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas. Kretsch AM, Morgan GL, Tyrrell J, Mevers E, Vallet-Gély I, Li B Organic letters 30073838 Org Lett 2018 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/30073838
A Permissive Amide N-Methyltransferase for Dithiolopyrrolones. Chen X, Johnson RM, Li B ACS catalysis 38106463 ACS Catal 2023 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/38106463
Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. Santa Maria KC, Chan AN, O'Neill EM, Li B Chembiochem : a European journal of chemical biology 30694017 Chembiochem 2019 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/30694017
Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. Johnson RA, Chan AN, Ward RD, McGlade CA, Hatfield BM, Peters JM, Li B Journal of the American Chemical Society 34342433 J Am Chem Soc 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34342433
The Hybrid Antibiotic Thiomarinol A Overcomes Intrinsic Resistance in Escherichia coli Using a Privileged Dithiolopyrrolone Moiety. Johnson RM, Li K, Chen X, Morgan GL, Aubé J, Li B ACS infectious diseases 38226592 ACS Infect Dis 2024 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/38226592
Pseudomonas Virulence Factor Pathway Synthesizes Autoinducers That Regulate the Secretome of a Pathogen. Kretsch AM, Morgan GL, Acken KA, Barr SA, Li B ACS chemical biology 33595276 ACS Chem Biol 2021 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/33595276
In Vitro Reconstitution Reveals a Central Role for the N-Oxygenase PvfB in (Dihydro)pyrazine-N-oxide and Valdiazen Biosynthesis. Morgan GL, Li B Angewandte Chemie (International ed. in English) 32662921 Angew Chem Int Ed Engl 2020 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/32662921
Purification and characterization of tomato arginine decarboxylase and its inhibition by the bacterial small molecule phevamine A. Guo Q, Chen X, Li B Protein expression and purification 37348664 Protein Expr Purif 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37348664
Activation of Dithiolopyrrolone Antibiotics by Cellular Reductants. Steiner OM, Johnson RA, Chen X, Simke WC, Li B Biochemistry 39665630 Biochemistry 2025 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/39665630
Parallel High-Resolution Imaging of Leukocyte Chemotaxis Under Agarose with Rho-Family GTPase Biosensors. Bell GRR, Natwick DE, Collins SR Methods in molecular biology (Clifton, N.J.) 30062406 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30062406
Optimized iLID Membrane Anchors for Local Optogenetic Protein Recruitment. Natwick DE, Collins SR ACS synthetic biology 33843200 ACS Synth Biol 2021 May 21 https://www.ncbi.nlm.nih.gov/pubmed/33843200
Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity. Hadjitheodorou A, Bell GRR, Ellett F, Shastry S, Irimia D, Collins SR, Theriot JA Nature communications 34785640 Nat Commun 2021 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/34785640
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors. Lundgren SM, Rocha-Gregg BL, Akdoğan E, Mysore MN, Hayes S, Collins SR Science signaling 37788324 Sci Signal 2023 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/37788324
Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology. Badu-Nkansah KA, Sernas D, Natwick DE, Collins SR Methods in molecular biology (Clifton, N.J.) 36227545 Methods Mol Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36227545
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens. Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC Nature genetics 30397336 Nat Genet 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30397336
"Rho"ing a Cellular Boat with Rearward Membrane Flow. Bell GRR, Collins SR Developmental cell 29974859 Dev Cell 2018 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/29974859
Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Belliveau NM, Footer MJ, Akdoǧan E, van Loon AP, Collins SR, Theriot JA Nature communications 37723145 Nat Commun 2023 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/37723145
Flagella-driven motility is a target of human Paneth cell defensin activity. Akahoshi DT, Natwick DE, Yuan W, Lu W, Collins SR, Bevins CL PLoS pathogens 36821624 PLoS Pathog 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36821624
Decoding GEFs of animated cells. Natwick DE, Collins SR Nature chemical biology 32694631 Nat Chem Biol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32694631
Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing. Bell GRR, Rincón E, Akdoğan E, Collins SR Nature communications 34785668 Nat Commun 2021 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/34785668
A map of gene expression in neutrophil-like cell lines. Rincón E, Rocha-Gregg BL, Collins SR BMC genomics 30068296 BMC Genomics 2018 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/30068296
Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes. Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Rixon JA, Mahan SP, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Bäumler AJ Cell host & microbe 35568027 Cell Host Microbe 2022 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/35568027
Neutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation. Bhakta SB, Lundgren SM, Sesti BN, Flores BA, Akdogan E, Collins SR, Mercer F PloS one 38324578 PLoS One 2024 https://www.ncbi.nlm.nih.gov/pubmed/38324578
Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis. VanderVorst K, Dreyer CA, Hatakeyama J, Bell GRR, Learn JA, Berg AL, Hernandez M, Lee H, Collins SR, Carraway KL 3rd Breast cancer research : BCR 37147680 Breast Cancer Res 2023 May 5 https://www.ncbi.nlm.nih.gov/pubmed/37147680
Leading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration. Hadjitheodorou A, Bell GRR, Ellett F, Irimia D, Tibshirani R, Collins SR, Theriot JA Cell systems 36827986 Cell Syst 2023 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36827986
A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties. Dreyer CA, VanderVorst K, Natwick D, Bell G, Sood P, Hernandez M, Angelastro JM, Collins SR, Carraway KL 3rd Cancer letters 37336284 Cancer Lett 2023 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/37336284
Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling. Falo-Sanjuan J, Lammers NC, Garcia HG, Bray SJ Developmental cell 31378591 Dev Cell 2019 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/31378591
Genetically Encoded Fluorescent Biosensor for Rapid Detection of Protein Expression. Eason MG, Pandelieva AT, Mayer MM, Khan ST, Garcia HG, Chica RA ACS synthetic biology 33044070 ACS Synth Biol 2020 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/33044070
LlamaTags: A Versatile Tool to Image Transcription Factor Dynamics in Live Embryos. Bothma JP, Norstad MR, Alamos S, Garcia HG Cell 29754814 Cell 2018 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/29754814
Lighting up the central dogma for predictive developmental biology. Garcia HG, Berrocal A, Kim YJ, Martini G, Zhao J Current topics in developmental biology 32143740 Curr Top Dev Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32143740
Minimal synthetic enhancers reveal control of the probability of transcriptional engagement and its timing by a morphogen gradient. Alamos S, Reimer A, Westrum C, Turner MA, Talledo P, Zhao J, Luu E, Garcia HG Cell systems 36696901 Cell Syst 2023 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36696901
Chromatin Changes in Phytochrome Interacting Factor-Regulated Genes Parallel Their Rapid Transcriptional Response to Light. González-Grandío E, Álamos S, Zhang Y, Dalton-Roesler J, Niyogi KK, García HG, Quail PH Frontiers in plant science 35251080 Front Plant Sci 2022 https://www.ncbi.nlm.nih.gov/pubmed/35251080
Single cell biology-a Keystone Symposia report. Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, Guilliams M, Alon U, Shalek AK, Hamel R, Pfau SJ, Raj A, Quake SR, Zhang NR, Fan J, Trapnell C, Wang B, Greenwald NF, Vento-Tormo R, Santos SDM, Spencer SL, Garcia HG, Arekatla G, Gaiti F, Arbel-Goren R, Rulands S, Junker JP, Klein AM, Morris SA, Murray JI, Galloway KE, Ratz M, Romeike M Annals of the New York Academy of Sciences 34605044 Ann N Y Acad Sci 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34605044
DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins. Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BVL, Garcia HG, Qian SB, Brunkard JO, Roeder AHK Developmental cell 39305905 Dev Cell 2024 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/39305905
Quantitative imaging of RNA polymerase II activity in plants reveals the single-cell basis of tissue-wide transcriptional dynamics. Alamos S, Reimer A, Niyogi KK, Garcia HG Nature plants 34373604 Nat Plants 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34373604
Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility. Eck E, Liu J, Kazemzadeh-Atoufi M, Ghoreishi S, Blythe SA, Garcia HG eLife 33074101 Elife 2020 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/33074101
A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting. Lammers NC, Kim YJ, Zhao J, Garcia HG Current opinion in cell biology 33242838 Curr Opin Cell Biol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33242838
The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output. Yamada S, Whitney PH, Huang SK, Eck EC, Garcia HG, Rushlow CA Current biology : CB 30982648 Curr Biol 2019 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/30982648
Multimodal transcriptional control of pattern formation in embryonic development. Lammers NC, Galstyan V, Reimer A, Medin SA, Wiggins CH, Garcia HG Proceedings of the National Academy of Sciences of the United States of America 31882445 Proc Natl Acad Sci U S A 2020 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/31882445
Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila. Child MB 6th, Bateman JR, Jahangiri A, Reimer A, Lammers NC, Sabouni N, Villamarin D, McKenzie-Smith GC, Johnson JE, Jost D, Garcia HG eLife 34100718 Elife 2021 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/34100718
Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer. Kim YJ, Rhee K, Liu J, Jeammet S, Turner MA, Small SJ, Garcia HG eLife 36503705 Elife 2022 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/36503705
Single Molecule Imaging in Live Embryos Using Lattice Light-Sheet Microscopy. Mir M, Reimer A, Stadler M, Tangara A, Hansen AS, Hockemeyer D, Eisen MB, Garcia H, Darzacq X Methods in molecular biology (Clifton, N.J.) 29956254 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29956254
Real-time single-cell characterization of the eukaryotic transcription cycle reveals correlations between RNA initiation, elongation, and cleavage. Liu J, Hansen D, Eck E, Kim YJ, Turner M, Alamos S, Garcia HG PLoS computational biology 34003867 PLoS Comput Biol 2021 May https://www.ncbi.nlm.nih.gov/pubmed/34003867
Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene. Berrocal A, Lammers NC, Garcia HG, Eisen MB eLife 33300492 Elife 2020 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/33300492
Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression. Phillips R, Belliveau NM, Chure G, Garcia HG, Razo-Mejia M, Scholes C Annual review of biophysics 31084583 Annu Rev Biophys 2019 May 6 https://www.ncbi.nlm.nih.gov/pubmed/31084583
Competing constraints shape the nonequilibrium limits of cellular decision-making. Lammers NC, Flamholz AI, Garcia HG Proceedings of the National Academy of Sciences of the United States of America 36862689 Proc Natl Acad Sci U S A 2023 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/36862689
TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Shen YC, Shami AN, Moritz L, Larose H, Manske GL, Ma Q, Zheng X, Sukhwani M, Czerwinski M, Sultan C, Chen H, Gurczynski SJ, Spence JR, Orwig KE, Tallquist M, Li JZ, Hammoud SS Nature communications 34162856 Nat Commun 2021 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/34162856
Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis. Shami AN, Zheng X, Munyoki SK, Ma Q, Manske GL, Green CD, Sukhwani M, Orwig KE, Li JZ, Hammoud SS Developmental cell 32504559 Dev Cell 2020 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/32504559
Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq. Ulrich ND, Shen YC, Ma Q, Yang K, Hannum DF, Jones A, Machlin J, Randolph JF Jr, Smith YR, Schon SB, Shikanov A, Marsh EE, Lieberman R, Gurczynski SJ, Moore BB, Li JZ, Hammoud S Developmental cell 35320732 Dev Cell 2022 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/35320732
Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women. Ulrich ND, Vargo A, Ma Q, Shen YC, Bazzano D, Hannum DF, Gurczynski SJ, Moore BB, Schon S, Lieberman R, Shikanov A, Marsh EE, Fazleabas A, Li JZ, Hammoud SS Proceedings of the National Academy of Sciences of the United States of America 39471215 Proc Natl Acad Sci U S A 2024 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/39471215
Decoding the Spermatogenesis Program: New Insights from Transcriptomic Analyses. Rabbani M, Zheng X, Manske GL, Vargo A, Shami AN, Li JZ, Hammoud SS Annual review of genetics 36070560 Annu Rev Genet 2022 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/36070560
Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility. Schon SB, Moritz L, Rabbani M, Meguid J, Juliano BR, Ruotolo BT, Aston K, Hammoud SS F&S science 38065301 F S Sci 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38065301
Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells. Ma B, Yang G, Yao J, Wu C, Vega JP, Manske G, Hammoud SS, Sinha S, Singh A, Zhao H, Chen X bioRxiv : the preprint server for biology 40093102 bioRxiv 2025 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/40093102
Regulation of meiotic progression by Sertoli-cell androgen signaling. Larose H, Kent T, Ma Q, Shami AN, Harerimana N, Li JZ, Hammoud SS, Handel MA Molecular biology of the cell 33026960 Mol Biol Cell 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/33026960
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline. Graniel JV, Bisht K, Friedman A, White J, Perkey E, Vanderbeck A, Moroz A, Carrington LJ, Brandstadter JD, Allen F, Shami AN, Thomas P, Crayton A, Manzor M, Mychalowych A, Chase J, Hammoud SS, Keegan CE, Maillard I, Nandakumar J Life science alliance 34645668 Life Sci Alliance 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34645668
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1. Moritz L, Schon SB, Rabbani M, Sheng Y, Agrawal R, Glass-Klaiber J, Sultan C, Camarillo JM, Clements J, Baldwin MR, Diehl AG, Boyle AP, O'Brien PJ, Ragunathan K, Hu YC, Kelleher NL, Nandakumar J, Li JZ, Orwig KE, Redding S, Hammoud SS Nature structural & molecular biology 37460896 Nat Struct Mol Biol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37460896
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq. Green CD, Ma Q, Manske GL, Shami AN, Zheng X, Marini S, Moritz L, Sultan C, Gurczynski SJ, Moore BB, Tallquist MD, Li JZ, Hammoud SS Developmental cell 30146481 Dev Cell 2018 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/30146481
Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. Grill S, Bisht K, Tesmer VM, Shami AN, Hammoud SS, Nandakumar J Cell reports 31216472 Cell Rep 2019 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/31216472
The Art of Packaging the Sperm Genome: Molecular and Structural Basis of the Histone-To-Protamine Exchange. Moritz L, Hammoud SS Frontiers in endocrinology 35813619 Front Endocrinol (Lausanne) 2022 https://www.ncbi.nlm.nih.gov/pubmed/35813619
Genetic determinants of cellular addiction to DNA polymerase theta. Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP Nature communications 31537809 Nat Commun 2019 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/31537809
The structure of the human cell cycle. Stallaert W, Kedziora KM, Taylor CD, Zikry TM, Ranek JS, Sobon HK, Taylor SR, Young CL, Cook JG, Purvis JE Cell systems 34800361 Cell Syst 2022 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/34800361
Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction. Ranek JS, Stanley N, Purvis JE Genome biology 36064614 Genome Biol 2022 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/36064614
Autophagy regulates the localization and degradation of p16(INK4a). Coryell PR, Goraya SK, Griffin KA, Redick MA, Sisk SR, Purvis JE Aging cell 32662244 Aging Cell 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32662244
Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Enrico TP, Stallaert W, Wick ET, Ngoi P, Wang X, Rubin SM, Brown NG, Purvis JE, Emanuele MJ eLife 34851822 Elife 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/34851822
The structure of the human cell cycle. Stallaert W, Kedziora KM, Taylor CD, Zikry TM, Ranek JS, Sobon HK, Taylor SR, Young CL, Cook JG, Purvis JE Cell systems 35051372 Cell Syst 2022 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/35051372
The Cell Cycle Browser: An Interactive Tool for Visualizing, Simulating, and Perturbing Cell-Cycle Progression. Borland D, Yi H, Grant GD, Kedziora KM, Chao HX, Haggerty RA, Kumar J, Wolff SC, Cook JG, Purvis JE Cell systems 30077635 Cell Syst 2018 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/30077635
Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle. Chao HX, Poovey CE, Privette AA, Grant GD, Chao HY, Cook JG, Purvis JE Cell systems 29102360 Cell Syst 2017 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/29102360
Natural language processing: put your model where your mouth is. Haggerty RA, Purvis JE Molecular systems biology 29254950 Mol Syst Biol 2017 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/29254950
Inferring the structures of signaling motifs from paired dynamic traces of single cells. Haggerty RA, Purvis JE PLoS computational biology 33539338 PLoS Comput Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33539338
Bistable switches as integrators and actuators during cell cycle progression. Stallaert W, Kedziora KM, Chao HX, Purvis JE FEBS letters 31566708 FEBS Lett 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31566708
The consequences of differential origin licensing dynamics in distinct chromatin environments. Mei L, Kedziora KM, Song EA, Purvis JE, Cook JG Nucleic acids research 35079814 Nucleic Acids Res 2022 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/35079814
Inheritance of OCT4 predetermines fate choice in human embryonic stem cells. Wolff SC, Kedziora KM, Dumitru R, Dungee CD, Zikry TM, Beltran AS, Haggerty RA, Cheng J, Redick MA, Purvis JE Molecular systems biology 30177503 Mol Syst Biol 2018 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/30177503
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. Kumar RJ, Chao HX, Simpson DA, Feng W, Cho MG, Roberts VR, Sullivan AR, Shah SJ, Wozny AS, Fagan-Solis K, Kumar S, Luthman A, Ramsden DA, Purvis JE, Gupta GP NAR cancer 33385162 NAR Cancer 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33385162
Chemical screen for epigenetic barriers to single allele activation of Oct4. Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA Stem cell research 31170660 Stem Cell Res 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31170660
Evidence that the human cell cycle is a series of uncoupled, memoryless phases. Chao HX, Fakhreddin RI, Shimerov HK, Kedziora KM, Kumar RJ, Perez J, Limas JC, Grant GD, Cook JG, Gupta GP, Purvis JE Molecular systems biology 30886052 Mol Syst Biol 2019 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/30886052
Accurate delineation of cell cycle phase transitions in living cells with PIP-FUCCI. Grant GD, Kedziora KM, Limas JC, Cook JG, Purvis JE Cell cycle (Georgetown, Tex.) 30421640 Cell Cycle 2018 https://www.ncbi.nlm.nih.gov/pubmed/30421640
Rapid DNA replication origin licensing protects stem cell pluripotency. Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG eLife 29148972 Elife 2017 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/29148972
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics. Burclaff J, Bliton RJ, Breau KA, Ok MT, Gomez-Martinez I, Ranek JS, Bhatt AP, Purvis JE, Woosley JT, Magness ST Cellular and molecular gastroenterology and hepatology 35176508 Cell Mol Gastroenterol Hepatol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35176508
Exposure, hazard, and survival analysis of diffusion on social networks. Wu J, Crawford FW, Kim DA, Stafford D, Christakis NA Statistics in medicine 29707798 Stat Med 2018 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/29707798
Dynamics of the HIV outbreak and response in Scott County, IN, USA, 2011-15: a modelling study. Gonsalves GS, Crawford FW The lancet. HIV 30220531 Lancet HIV 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30220531
Hidden population size estimation from respondent-driven sampling: a network approach. Crawford FW, Wu J, Heimer R Journal of the American Statistical Association 30828120 J Am Stat Assoc 2018 https://www.ncbi.nlm.nih.gov/pubmed/30828120
Estimating dose-specific cell division and apoptosis rates from chemo-sensitivity experiments. Liu Y, Crawford FW Scientific reports 29426887 Sci Rep 2018 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/29426887
Predictors of Mortality within Prison and after Release among Persons Living with HIV in Indonesia. Culbert GJ, Crawford FW, Murni A, Waluyo A, Bazazi AR, Sahar J, Altice FL Research and reports in tropical medicine 29238241 Res Rep Trop Med 2017 https://www.ncbi.nlm.nih.gov/pubmed/29238241
The Burden of Stigma on Health and Well-Being: A Taxonomy of Concealment, Course, Disruptiveness, Aesthetics, Origin, and Peril Across 93 Stigmas. Pachankis JE, Hatzenbuehler ML, Wang K, Burton CL, Crawford FW, Phelan JC, Link BG Personality & social psychology bulletin 29290150 Pers Soc Psychol Bull 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29290150
Violence and Discrimination Against Men Who Have Sex With Men in Lebanon: The Role of International Displacement and Migration. Orr L, Shebl FM, Heimer R, Khoshnood K, Barbour R, Khouri D, Aaraj E, Mokhbat JE, Crawford FW Journal of interpersonal violence 31658847 J Interpers Violence 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/31658847
Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis. Crawford FW, Marx FM, Zelner J, Cohen T Epidemiology (Cambridge, Mass.) 31764276 Epidemiology 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31764276
SARS-CoV-2 attack rate and population immunity in southern New England, March 2020 - May 2021. Tran TN, Wikle NB, Yang F, Inam H, Leighow S, Gentilesco B, Chan P, Albert E, Strong ER, Pritchard JR, Hanage WP, Hanks EM, Crawford FW, Boni MF medRxiv : the preprint server for health sciences 34909789 medRxiv 2021 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/34909789
Randomization for the susceptibility effect of an infectious disease intervention. Eck DJ, Morozova O, Crawford FW Journal of mathematical biology 36127558 J Math Biol 2022 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/36127558
Impact of close interpersonal contact on COVID-19 incidence: Evidence from 1 year of mobile device data. Crawford FW, Jones SA, Cartter M, Dean SG, Warren JL, Li ZR, Barbieri J, Campbell J, Kenney P, Valleau T, Morozova O Science advances 34995121 Sci Adv 2022 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/34995121
Evaluating the Mediating Role of Recall of Intervention Knowledge in the Relationship Between a Peer-Driven Intervention and HIV Risk Behaviors Among People Who Inject Drugs. Aroke H, Buchanan A, Katenka N, Crawford FW, Lee T, Halloran ME, Latkin C AIDS and behavior 35932359 AIDS Behav 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/35932359
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE Science (New York, N.Y.) 35084937 Science 2022 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/35084937
An Adaptive Approach to Locating Mobile HIV Testing Services. Gonsalves GS, Crawford FW, Cleary PD, Kaplan EH, Paltiel AD Medical decision making : an international journal of the Society for Medical Decision Making 28699382 Med Decis Making 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/28699382
Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis. Li ZR, Xie E, Crawford FW, Warren JL, McConnell K, Copple JT, Johnson T, Gonsalves GS PLoS medicine 31714940 PLoS Med 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31714940
Divergent estimates of HIV incidence among people who inject drugs in Ukraine. Morozova O, Booth RE, Dvoriak S, Dumchev K, Sazonova Y, Saliuk T, Crawford FW The International journal on drug policy 31405731 Int J Drug Policy 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31405731
One year of modeling and forecasting COVID-19 transmission to support policymakers in Connecticut. Morozova O, Li ZR, Crawford FW Scientific reports 34642405 Sci Rep 2021 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/34642405
Using sigLASSO to optimize cancer mutation signatures jointly with sampling likelihood. Li S, Crawford FW, Gerstein MB Nature communications 32681003 Nat Commun 2020 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/32681003
One year of modeling and forecasting COVID-19 transmission to support policymakers in Connecticut. Morozova O, Li ZR, Crawford FW medRxiv : the preprint server for health sciences 32587978 medRxiv 2021 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/32587978
Computational methods for birth-death processes. Crawford FW, Ho LST, Suchard MA Wiley interdisciplinary reviews. Computational statistics 29942419 Wiley Interdiscip Rev Comput Stat 2018 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/29942419
Estimates of people who injected drugs within the last 12 months in Belgium based on a capture-recapture and multiplier method. Plettinckx E, Crawford FW, Antoine J, Gremeaux L, Van Baelen L Drug and alcohol dependence 33310486 Drug Alcohol Depend 2021 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/33310486
Randomized controlled trials of biomarker targets. Erlendsdottir M, Crawford FW Clinical trials (London, England) 36373783 Clin Trials 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36373783
Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009-2019. Lu H, Crawford FW, Gonsalves GS, Grau LE Annals of epidemiology 36669599 Ann Epidemiol 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36669599
Interpretation of the Individual Effect Under Treatment Spillover. Crawford FW, Morozova O, Buchanan AL, Spiegelman D American journal of epidemiology 31094425 Am J Epidemiol 2019 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/31094425
COVID-19 projections for reopening Connecticut. Crawford FW, Li ZR, Morozova O medRxiv : the preprint server for health sciences 32588003 medRxiv 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32588003
Identification of causal intervention effects under contagion. Cai X, Loh WW, Crawford FW Journal of causal inference 34676152 J Causal Inference 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/34676152
Cost-effectiveness of expanding the capacity of opioid agonist treatment in Ukraine: dynamic modeling analysis. Morozova O, Crawford FW, Cohen T, Paltiel AD, Altice FL Addiction (Abingdon, England) 31478285 Addiction 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31478285
Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V The New England journal of medicine 32242365 N Engl J Med 2020 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/32242365
HIV Risk, Prevalence, and Access to Care Among Men Who Have Sex with Men in Lebanon. Heimer R, Barbour R, Khouri D, Crawford FW, Shebl F, Aaraj E, Khoshnood K AIDS research and human retroviruses 28540733 AIDS Res Hum Retroviruses 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28540733
Estimating the early death toll of COVID-19 in the United States. Weinberger DM, Cohen T, Crawford FW, Mostashari F, Olson D, Pitzer VE, Reich NG, Russi M, Simonsen L, Watkins A, Viboud C medRxiv : the preprint server for health sciences 32511293 medRxiv 2020 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/32511293
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE medRxiv : the preprint server for health sciences 34981074 medRxiv 2021 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/34981074
Opioid Agonist Treatment and Improved Outcomes at Each Stage of the HIV Treatment Cascade in People Who Inject Drugs in Ukraine. Mazhnaya A, Marcus R, Bojko MJ, Zelenev A, Makarenko I, Pykalo I, Filippovych S, Dvoriak S, Altice FL Journal of acquired immune deficiency syndromes (1999) 30312275 J Acquir Immune Defic Syndr 2018 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/30312275
Estimating the Size of a Large Network and its Communities from a Random Sample. Chen L, Karbasi A, Crawford FW Advances in neural information processing systems 28867924 Adv Neural Inf Process Syst 2016 https://www.ncbi.nlm.nih.gov/pubmed/28867924
HIV Testing and awareness of HIV status among people who inject drugs in greater Kuala Lumpur, Malaysia. Bazazi AR, Vijay A, Crawford FW, Heimer R, Kamarulzaman A, Altice FL AIDS care 28803503 AIDS Care 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28803503
Empirical evidence of recruitment bias in a network study of people who inject drugs. Zeng L, Li J, Crawford FW The American journal of drug and alcohol abuse 30896982 Am J Drug Alcohol Abuse 2019 https://www.ncbi.nlm.nih.gov/pubmed/30896982
Risk ratios for contagious outcomes. Morozova O, Cohen T, Crawford FW Journal of the Royal Society, Interface 29343627 J R Soc Interface 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29343627
Impact of close interpersonal contact on COVID-19 incidence: evidence from one year of mobile device data. Crawford FW, Jones SA, Cartter M, Dean SG, Warren JL, Li ZR, Barbieri J, Campbell J, Kenney P, Valleau T, Morozova O medRxiv : the preprint server for health sciences 33758869 medRxiv 2021 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/33758869
Dependence-Robust Confidence Intervals for Capture-Recapture Surveys. Sun J, Van Baelen L, Plettinckx E, Crawford FW Journal of survey statistics and methodology 37975066 J Surv Stat Methodol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37975066
A semi-synthetic regulon enables rapid growth of yeast on xylose. Endalur Gopinarayanan V, Nair NU Nature communications 29581426 Nat Commun 2018 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/29581426
Directed evolution of Anabaena variabilis phenylalanine ammonia-lyase (PAL) identifies mutants with enhanced activities. Mays ZJ , Mohan K , Trivedi VD , Chappell TC , Nair NU Chemical communications (Cambridge, England) 32270162 Chem Commun (Camb) 2020 May 14 https://www.ncbi.nlm.nih.gov/pubmed/32270162
Pentose Metabolism in Saccharomyces cerevisiae: The Need to Engineer Global Regulatory Systems. Endalur Gopinarayanan V, Nair NU Biotechnology journal 30171750 Biotechnol J 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30171750
A quantitative model for metabolic intervention using gut microbes. Mays ZJS, Nair NU Biotechnology progress 33426814 Biotechnol Prog 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33426814
Engineered lactobacilli display anti-biofilm and growth suppressing activities against Pseudomonas aeruginosa. Chappell TC, Nair NU NPJ biofilms and microbiomes 33127888 NPJ Biofilms Microbiomes 2020 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/33127888
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates. Trivedi VD, Sullivan SF, Choudhury D, Endalur Gopinarayanan V, Hart T, Nair NU Cell chemical biology 37421944 Cell Chem Biol 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37421944
Specific codons control cellular resources and fitness. Love AM, Nair NU Science advances 38381824 Sci Adv 2024 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/38381824
Synthetic biology in probiotic lactic acid bacteria: At the frontier of living therapeutics. Mays ZJ, Nair NU Current opinion in biotechnology 29550614 Curr Opin Biotechnol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29550614
Toward a genetic tool development pipeline for host-associated bacteria. Waller MC, Bober JR, Nair NU, Beisel CL Current opinion in microbiology 28624690 Curr Opin Microbiol 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28624690
Quantifying and Engineering Mucus Adhesion of Probiotics. Mays ZJS, Chappell TC, Nair NU ACS synthetic biology 31909976 ACS Synth Biol 2020 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/31909976
Galactose to tagatose isomerization at moderate temperatures with high conversion and productivity. Bober JR, Nair NU Nature communications 31591402 Nat Commun 2019 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/31591402
Cheating the Cheater: Suppressing False-Positive Enrichment during Biosensor-Guided Biocatalyst Engineering. Trivedi VD, Mohan K, Chappell TC, Mays ZJS, Nair NU ACS synthetic biology 34914365 ACS Synth Biol 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/34914365
A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy. d'Amone L, Trivedi VD, Nair NU, Omenetto FG Molecular pharmaceutics 35862031 Mol Pharm 2022 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/35862031
Towards universal synthetic heterotrophy using a metabolic coordinator. Sullivan SF, Shetty A, Bharadwaj T, Krishna N, Trivedi VD, Endalur Gopinarayanan V, Chappell TC, Sellers DM, Pravin Kumar R, Nair NU Metabolic engineering 37406763 Metab Eng 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37406763
Establishing synthesis pathway-host compatibility via enzyme solubility. Amin SA, Endalur Gopinarayanan V, Nair NU, Hassoun S Biotechnology and bioengineering 30802311 Biotechnol Bioeng 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30802311
Towards creating an extended metabolic model (EMM) for E. coli using enzyme promiscuity prediction and metabolomics data. Amin SA, Chavez E, Porokhin V, Nair NU, Hassoun S Microbial cell factories 31196115 Microb Cell Fact 2019 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/31196115
Characterization of a membrane enzymatic complex for heterologous production of poly-γ-glutamate in E. coli. Motta Nascimento B, Nair NU Metabolic engineering communications 32963960 Metab Eng Commun 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32963960
Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications. Bober JR, Beisel CL, Nair NU Annual review of biomedical engineering 29528686 Annu Rev Biomed Eng 2018 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/29528686
In-depth Sequence-Function Characterization Reveals Multiple Pathways to Enhance Enzymatic Activity. Trivedi VD, Chappell TC, Krishna NB, Shetty A, Sigamani GG, Mohan K, Ramesh A, Pravin KR, Nair NU ACS catalysis 37325394 ACS Catal 2022 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/37325394
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Miller IC, Zamat A, Sun LK, Phuengkham H, Harris AM, Gamboa L, Yang J, Murad JP, Priceman SJ, Kwong GA Nature biomedical engineering 34385695 Nat Biomed Eng 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34385695
DNA-Barcoded pMHC Tetramers for Detection of Single Antigen-Specific T Cells by Digital PCR. Dahotre SN, Chang YM, Romanov AM, Kwong GA Analytical chemistry 30656939 Anal Chem 2019 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/30656939
Dimensionless parameter predicts bacterial prodrug success. Holt BA, Tuttle M, Xu Y, Su M, Røise JJ, Wang X, Murthy N, Kwong GA Molecular systems biology 35005851 Mol Syst Biol 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/35005851
Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains. Miller IC, Gamboa Castro M, Maenza J, Weis JP, Kwong GA ACS synthetic biology 29579381 ACS Synth Biol 2018 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/29579381
Deconvolving multiplexed protease signatures with substrate reduction and activity clustering. Zhuang Q, Holt BA, Kwong GA, Qiu P PLoS computational biology 31479443 PLoS Comput Biol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31479443
Interfacing Biomaterials with Synthetic T Cell Immunity. Su FY, Mac QD, Sivakumar A, Kwong GA Advanced healthcare materials 33887123 Adv Healthc Mater 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33887123
Macrophage Sensors for Early Cancer Detection. Kwong GA Clinical chemistry 32040571 Clin Chem 2020 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/32040571
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics. Holt BA, Mac QD, Kwong GA Journal of visualized experiments : JoVE 30059042 J Vis Exp 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30059042
Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity. Mac QD, Mathews DV, Kahla JA, Stoffers CM, Delmas OM, Holt BA, Adams AB, Kwong GA Nature biomedical engineering 30952979 Nat Biomed Eng 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30952979
Synthetic immunity by remote control. Gamboa L, Zamat AH, Kwong GA Theranostics 32206114 Theranostics 2020 https://www.ncbi.nlm.nih.gov/pubmed/32206114
Individually addressable and dynamic DNA gates for multiplexed cell sorting. Dahotre SN, Chang YM, Wieland A, Stammen SR, Kwong GA Proceedings of the National Academy of Sciences of the United States of America 29632190 Proc Natl Acad Sci U S A 2018 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/29632190
Heat-Triggered Remote Control of CRISPR-dCas9 for Tunable Transcriptional Modulation. Gamboa L, Phung EV, Li H, Meyers JP, Hart AC, Miller IC, Kwong GA ACS chemical biology 31904924 ACS Chem Biol 2020 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/31904924
In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles. Su FY, Zhao QH, Dahotre SN, Gamboa L, Bawage SS, Silva Trenkle AD, Zamat A, Phuengkham H, Ahmed R, Santangelo PJ, Kwong GA Science advances 35196075 Sci Adv 2022 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/35196075
Embracing enzyme promiscuity with activity-based compressed biosensing. Holt BA, Lim HS, Sivakumar A, Phuengkham H, Su M, Tuttle M, Xu Y, Liakakos H, Qiu P, Kwong GA Cell reports methods 36814844 Cell Rep Methods 2023 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/36814844
AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity. Sivakumar A, Phuengkham H, Rajesh H, Mac QD, Rogers LC, Silva Trenkle AD, Bawage SS, Hincapie R, Li Z, Vainikos S, Lee I, Xue M, Qiu P, Finn MG, Kwong GA Nature nanotechnology 39753733 Nat Nanotechnol 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39753733
Synthetic biomarkers: a twenty-first century path to early cancer detection. Kwong GA, Ghosh S, Gamboa L, Patriotis C, Srivastava S, Bhatia SN Nature reviews. Cancer 34489588 Nat Rev Cancer 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34489588
Synthetic Antigen-Presenting Cells for Adoptive T Cell Therapy. Dahotre SN, Romanov AM, Su FY, Kwong GA Advanced therapeutics 34541300 Adv Ther (Weinh) 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34541300
Protease circuits for processing biological information. Holt BA, Kwong GA Nature communications 33024117 Nat Commun 2020 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/33024117
Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors. Mac QD, Sivakumar A, Phuengkham H, Xu C, Bowen JR, Su FY, Stentz SZ, Sim H, Harris AM, Li TT, Qiu P, Kwong GA Nature biomedical engineering 35241815 Nat Biomed Eng 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35241815
Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis. Hanchate NK, Kondoh K, Lu Z, Kuang D, Ye X, Qiu X, Pachter L, Trapnell C, Buck LB Science (New York, N.Y.) 26541607 Science 2015 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/26541607
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution. Packer JS, Zhu Q, Huynh C, Sivaramakrishnan P, Preston E, Dueck H, Stefanik D, Tan K, Trapnell C, Kim J, Waterston RH, Murray JI Science (New York, N.Y.) 31488706 Science 2019 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/31488706
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice. Mucci A, Lopez-Rodriguez E, Hetzel M, Liu S, Suzuki T, Happle C, Ackermann M, Kempf H, Hillje R, Kunkiel J, Janosz E, Brennig S, Glage S, Bankstahl JP, Dettmer S, Rodt T, Gohring G, Trapnell B, Hansen G, Trapnell C, Knudsen L, Lachmann N, Moritz T Stem cell reports 30100408 Stem Cell Reports 2018 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/30100408
Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome. Cacchiarelli D, Qiu X, Srivatsan S, Manfredi A, Ziller M, Overbey E, Grimaldi A, Grimsby J, Pokharel P, Livak KJ, Li S, Meissner A, Mikkelsen TS, Rinn JL, Trapnell C Cell systems 30195438 Cell Syst 2018 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/30195438
Defining cell types and states with single-cell genomics. Trapnell C Genome research 26430159 Genome Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26430159
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy. McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C Cell genomics 38278156 Cell Genom 2024 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/38278156
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gürtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D Cell 30661759 Cell 2019 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/30661759
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens. Gasperini M, Hill AJ, McFaline-Figueroa JL, Martin B, Kim S, Zhang MD, Jackson D, Leith A, Schreiber J, Noble WS, Trapnell C, Ahituv N, Shendure J Cell 30612741 Cell 2019 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/30612741
Dimensionality reduction by UMAP to visualize physical and genetic interactions. Dorrity MW, Saunders LM, Queitsch C, Fields S, Trapnell C Nature communications 32210240 Nat Commun 2020 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/32210240
MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays. Rubin AF, Stone J, Bianchi AH, Capodanno BJ, Da EY, Dias M, Esposito D, Frazer J, Fu Y, Grindstaff SB, Harrington MR, Li I, McEwen AE, Min JK, Moore N, Moscatelli OG, Ong J, Polunina PV, Rollins JE, Rollins NJ, Snyder AE, Tam A, Wakefield MJ, Ye SS, Starita LM, Bryant VL, Marks DS, Fowler DM Genome biology 39838450 Genome Biol 2025 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/39838450
Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation. Packer J, Trapnell C Trends in genetics : TIG 30007833 Trends Genet 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30007833
Joint profiling of chromatin accessibility and gene expression in thousands of single cells. Cao J, Cusanovich DA, Ramani V, Aghamirzaie D, Pliner HA, Hill AJ, Daza RM, McFaline-Figueroa JL, Packer JS, Christiansen L, Steemers FJ, Adey AC, Trapnell C, Shendure J Science (New York, N.Y.) 30166440 Science 2018 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/30166440
Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data. Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C Molecular cell 30078726 Mol Cell 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/30078726
Comprehensive single-cell transcriptional profiling of a multicellular organism. Cao J, Packer JS, Ramani V, Cusanovich DA, Huynh C, Daza R, Qiu X, Lee C, Furlan SN, Steemers FJ, Adey A, Waterston RH, Trapnell C, Shendure J Science (New York, N.Y.) 28818938 Science 2017 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/28818938
On the design of CRISPR-based single-cell molecular screens. Hill AJ, McFaline-Figueroa JL, Starita LM, Gasperini MJ, Matreyek KA, Packer J, Jackson D, Shendure J, Trapnell C Nature methods 29457792 Nat Methods 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29457792
Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. Saunders LM, Mishra AK, Aman AJ, Lewis VM, Toomey MB, Packer JS, Qiu X, McFaline-Figueroa JL, Corbo JC, Trapnell C, Parichy DM eLife 31140974 Elife 2019 May 29 https://www.ncbi.nlm.nih.gov/pubmed/31140974
A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility. Cusanovich DA, Hill AJ, Aghamirzaie D, Daza RM, Pliner HA, Berletch JB, Filippova GN, Huang X, Christiansen L, DeWitt WS, Lee C, Regalado SG, Read DF, Steemers FJ, Disteche CM, Trapnell C, Shendure J Cell 30078704 Cell 2018 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/30078704
Massively multiplex chemical transcriptomics at single-cell resolution. Srivatsan SR, McFaline-Figueroa JL, Ramani V, Saunders L, Cao J, Packer J, Pliner HA, Jackson DL, Daza RM, Christiansen L, Zhang F, Steemers F, Shendure J, Trapnell C Science (New York, N.Y.) 31806696 Science 2020 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/31806696
Sci-fate characterizes the dynamics of gene expression in single cells. Cao J, Zhou W, Steemers F, Trapnell C, Shendure J Nature biotechnology 32284584 Nat Biotechnol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32284584
High-throughput, microscope-based sorting to dissect cellular heterogeneity. Hasle N, Cooke A, Srivatsan S, Huang H, Stephany JJ, Krieger Z, Jackson D, Tang W, Pendyala S, Monnat RJ Jr, Trapnell C, Hatch EM, Fowler DM Molecular systems biology 32500953 Mol Syst Biol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32500953
Connect-seq to superimpose molecular on anatomical neural circuit maps. Hanchate NK, Lee EJ, Ellis A, Kondoh K, Kuang D, Basom R, Trapnell C, Buck LB Proceedings of the National Academy of Sciences of the United States of America 32034095 Proc Natl Acad Sci U S A 2020 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/32034095
A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition. McFaline-Figueroa JL, Hill AJ, Qiu X, Jackson D, Shendure J, Trapnell C Nature genetics 31477929 Nat Genet 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31477929
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface. Gabrovsek L, Collins KB, Aggarwal S, Saunders LM, Lau HT, Suh D, Sancak Y, Trapnell C, Ong SE, Smith FD, Scott JD The Journal of biological chemistry 32482893 J Biol Chem 2020 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/32482893
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy. McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C bioRxiv : the preprint server for biology 37398090 bioRxiv 2023 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/37398090
Single-cell mRNA quantification and differential analysis with Census. Qiu X, Hill A, Packer J, Lin D, Ma YA, Trapnell C Nature methods 28114287 Nat Methods 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28114287
Single-cell transcriptome sequencing: recent advances and remaining challenges. Liu S, Trapnell C F1000Research 26949524 F1000Res 2016 https://www.ncbi.nlm.nih.gov/pubmed/26949524
Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation. Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ The Journal of experimental medicine 30127060 J Exp Med 2018 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/30127060
Reversed graph embedding resolves complex single-cell trajectories. Qiu X, Mao Q, Tang Y, Wang L, Chawla R, Pliner HA, Trapnell C Nature methods 28825705 Nat Methods 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28825705
Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe. Qiu X, Rahimzamani A, Wang L, Ren B, Mao Q, Durham T, McFaline-Figueroa JL, Saunders L, Trapnell C, Kannan S Cell systems 32135093 Cell Syst 2020 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/32135093
The single-cell transcriptional landscape of mammalian organogenesis. Cao J, Spielmann M, Qiu X, Huang X, Ibrahim DM, Hill AJ, Zhang F, Mundlos S, Christiansen L, Steemers FJ, Trapnell C, Shendure J Nature 30787437 Nature 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30787437
Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, Engquist EN, Trapnell C, Gifford DK, Melton DA Cell reports 31116975 Cell Rep 2019 May 21 https://www.ncbi.nlm.nih.gov/pubmed/31116975
Supervised classification enables rapid annotation of cell atlases. Pliner HA, Shendure J, Trapnell C Nature methods 31501545 Nat Methods 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31501545
IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer. Furlan SN, Singh K, Lopez C, Tkachev V, Hunt DJ, Hibbard J, Betz KM, Blazar BR, Trapnell C, Kean LS Blood advances 32311015 Blood Adv 2020 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/32311015
Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana. Jean-Baptiste K, McFaline-Figueroa JL, Alexandre CM, Dorrity MW, Saunders L, Bubb KL, Trapnell C, Fields S, Queitsch C, Cuperus JT The Plant cell 30923229 Plant Cell 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30923229
The accessible chromatin landscape of the murine hippocampus at single-cell resolution. Sinnamon JR, Torkenczy KA, Linhoff MW, Vitak SA, Mulqueen RM, Pliner HA, Trapnell C, Steemers FJ, Mandel G, Adey AC Genome research 30936163 Genome Res 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30936163
Plug-and-play control of a brain-computer interface through neural map stabilization. Silversmith DB, Abiri R, Hardy NF, Natraj N, Tu-Chan A, Chang EF, Ganguly K Nature biotechnology 32895549 Nat Biotechnol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/32895549
Sampling representational plasticity of simple imagined movements across days enables long-term neuroprosthetic control. Natraj N, Seko S, Abiri R, Miao R, Yan H, Graham Y, Tu-Chan A, Chang EF, Ganguly K Cell 40054446 Cell 2025 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/40054446
Muscle synergies after stroke are correlated with perilesional high gamma. Godlove J, Gulati T, Dichter B, Chang E, Ganguly K Annals of clinical and translational neurology 28097208 Ann Clin Transl Neurol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/28097208
Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control. Natraj N, Seko S, Abiri R, Yan H, Graham Y, Tu-Chan A, Chang EF, Ganguly K bioRxiv : the preprint server for biology 37645922 bioRxiv 2023 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/37645922
Compartmentalized dynamics within a common multi-area mesoscale manifold represent a repertoire of human hand movements. Natraj N, Silversmith DB, Chang EF, Ganguly K Neuron 34678147 Neuron 2022 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/34678147
Cortical neuroprosthetics from a clinical perspective. Tsu AP, Burish MJ, GodLove J, Ganguly K Neurobiology of disease 26253606 Neurobiol Dis 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26253606
Embryonic Stem Cell Engineering with a Glycomimetic FGF2/BMP4 Co-Receptor Drives Mesodermal Differentiation in a Three-Dimensional Culture. Naticchia MR, Laubach LK, Tota EM, Lucas TM, Huang ML, Godula K ACS chemical biology 30157624 ACS Chem Biol 2018 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/30157624
Influencing Early Stages of Neuromuscular Junction Formation through Glycocalyx Engineering. Huang ML, Tota EM, Lucas TM, Godula K ACS chemical neuroscience 30095249 ACS Chem Neurosci 2018 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/30095249
Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Huang ML, Michalak AL, Fisher CJ, Christy M, Smith RAA, Godula K Stem cells (Dayton, Ohio) 28984039 Stem Cells 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28984039
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD Nature chemical biology 33846619 Nat Chem Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33846619
Body mass index, calcium supplementation and risk of colorectal adenomas. Barry EL, Lund JL, Westreich D, Mott LA, Ahnen DJ, Beck GJ, Bostick RM, Bresalier RS, Burke CA, Church TR, Rees JR, Robertson DJ, Baron JA International journal of cancer 30117164 Int J Cancer 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30117164
Generalizability of randomized trial results to target populations: Design and analysis possibilities. Stuart EA, Ackerman B, Westreich D Research on social work practice 30034203 Res Soc Work Pract 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/30034203
Invited Commentary: Beware the Test-Negative Design. Westreich D, Hudgens MG American journal of epidemiology 27587722 Am J Epidemiol 2016 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/27587722
The Authors Respond. Breskin A, Cole SR, Hudgens MG Epidemiology (Cambridge, Mass.) 30052540 Epidemiology 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30052540
Comparison of Methods to Generalize Randomized Clinical Trial Results Without Individual-Level Data for the Target Population. Hong JL, Webster-Clark M, Jonsson Funk M, Stürmer T, Dempster SE, Cole SR, Herr I, LoCasale R American journal of epidemiology 30312378 Am J Epidemiol 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30312378
The Effects of Hepatitis C Infection and Treatment on All-cause Mortality Among People Living With Human Immunodeficiency Virus. Breskin A, Westreich D, Cole SR, Hudgens MG, Hurt CB, Seaberg EC, Thio CL, Tien PC, Adimora AA Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 30321289 Clin Infect Dis 2019 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/30321289
Generalizing Randomized Clinical Trial Results: Implementation and Challenges Related to Missing Data in the Target Population. Hong JL, Jonsson Funk M, LoCasale R, Dempster SE, Cole SR, Webster-Clark M, Edwards JK, Stürmer T American journal of epidemiology 29020193 Am J Epidemiol 2018 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/29020193
Transporting Subgroup Analyses of Randomized Controlled Trials for Planning Implementation of New Interventions. Mehrotra ML, Westreich D, Glymour MM, Geng E, Glidden DV American journal of epidemiology 33615327 Am J Epidemiol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/33615327
The effect of early life antibiotic exposures on diarrheal rates among young children in Vellore, India. Rogawski ET, Westreich D, Becker-Dreps S, Adair LS, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick SR, Kang G The Pediatric infectious disease journal 25742244 Pediatr Infect Dis J 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25742244
Invited commentary: every good randomization deserves observation. Westreich D, Edwards JK American journal of epidemiology 26487342 Am J Epidemiol 2015 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/26487342
Causal Impact: Epidemiological Approaches for a Public Health of Consequence. Westreich D, Edwards JK, Rogawski ET, Hudgens MG, Stuart EA, Cole SR American journal of public health 27153017 Am J Public Health 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27153017
From Patients to Policy: Population Intervention Effects in Epidemiology. Westreich D Epidemiology (Cambridge, Mass.) 28282339 Epidemiology 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28282339
Marginal Structural Models for Risk or Prevalence Ratios for a Point Exposure Using a Disease Risk Score. Richardson DB, Keil AP, Kinlaw AC, Cole SR American journal of epidemiology 30726868 Am J Epidemiol 2019 May 1 https://www.ncbi.nlm.nih.gov/pubmed/30726868
Toward a Clearer Definition of Selection Bias When Estimating Causal Effects. Lu H, Cole SR, Howe CJ, Westreich D Epidemiology (Cambridge, Mass.) 35700187 Epidemiology 2022 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/35700187
Quantifying Cancer Risk from Radiation. Keil AP, Richardson DB Risk analysis : an official publication of the Society for Risk Analysis 29211917 Risk Anal 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29211917
Generalizing the per-protocol treatment effect: The case of ACTG A5095. Lu H, Cole SR, Hall HI, Schisterman EF, Breger TL, K Edwards J, Westreich D Clinical trials (London, England) 30326736 Clin Trials 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30326736
A review of time scale fundamentals in the g-formula and insidious selection bias. Keil AP, Edwards JK Current epidemiology reports 30555772 Curr Epidemiol Rep 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30555772
Using Bounds to Compare the Strength of Exchangeability Assumptions for Internal and External Validity. Breskin A, Westreich D, Cole SR, Edwards JK American journal of epidemiology 30834430 Am J Epidemiol 2019 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/30834430
UK Biobank, big data, and the consequences of non-representativeness. Keyes KM, Westreich D Lancet (London, England) 30938313 Lancet 2019 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/30938313
Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care. Bengtson AM, Pence BW, Gaynes BN, Quinlivan EB, Heine AD, OʼDonnell JK, Crane HM, Mathews WC, Moore RD, Westreich D, OʼCleirigh C, Christopoulos K, Mimiaga MJ, Mugavero MJ Journal of acquired immune deficiency syndromes (1999) 27668804 J Acquir Immune Defic Syndr 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27668804
Generalizing Study Results: A Potential Outcomes Perspective. Lesko CR, Buchanan AL, Westreich D, Edwards JK, Hudgens MG, Cole SR Epidemiology (Cambridge, Mass.) 28346267 Epidemiology 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28346267
Use of electronic health record data and machine learning to identify candidates for HIV pre-exposure prophylaxis: a modelling study. Marcus JL, Hurley LB, Krakower DS, Alexeeff S, Silverberg MJ, Volk JE The lancet. HIV 31285183 Lancet HIV 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31285183
Use of Intrauterine Devices and Risk of Human Immunodeficiency Virus Acquisition Among Insured Women in the United States. Marcus JL, Snowden JM, Murray Horwitz ME, Toh S, Horgan C, Tilney RC, Rajbhandari R, Back S, Westreich DJ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 31412356 Clin Infect Dis 2020 May 6 https://www.ncbi.nlm.nih.gov/pubmed/31412356
Brief Report: Estimating Differences and Ratios in Median Times to Event. Rogawski ET, Westreich DJ, Kang G, Ward HD, Cole SR Epidemiology (Cambridge, Mass.) 27465526 Epidemiology 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27465526
Smoking, HIV, and risk of pregnancy loss. Westreich D, Cates J, Cohen M, Weber KM, Seidman D, Cropsey K, Wright R, Milam J, Young MA, Mehta CC, Gustafson DR, Golub ET, Fischl MA, Adimora AA AIDS (London, England) 27902507 AIDS 2017 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/27902507
When Is a Complete-Case Approach to Missing Data Valid? The Importance of Effect-Measure Modification. Ross RK, Breskin A, Westreich D American journal of epidemiology 32601706 Am J Epidemiol 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/32601706
Estimating the Impact of Changes to Occupational Standards for Silica Exposure on Lung Cancer Mortality. Keil AP, Richardson DB, Westreich D, Steenland K Epidemiology (Cambridge, Mass.) 29870429 Epidemiology 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/29870429
Target Validity and the Hierarchy of Study Designs. Westreich D, Edwards JK, Lesko CR, Cole SR, Stuart EA American journal of epidemiology 30299451 Am J Epidemiol 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30299451
The Effects of Hepatitis C Treatment Eligibility Criteria on All-cause Mortality Among People With Human Immunodeficiency Virus. Breskin A, Westreich D, Hurt CB, Cole SR, Hudgens MG, Seaberg EC, Thio CL, Tien PC, Adimora AA Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 30615096 Clin Infect Dis 2019 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/30615096
An Illustration of Inverse Probability Weighting to Estimate Policy-Relevant Causal Effects. Edwards JK, Cole SR, Lesko CR, Mathews WC, Moore RD, Mugavero MJ, Westreich D American journal of epidemiology 27469514 Am J Epidemiol 2016 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/27469514
An updated systematic review of epidemiological evidence on hormonal contraceptive methods and HIV acquisition in women. Polis CB, Curtis KM, Hannaford PC, Phillips SJ, Chipato T, Kiarie JN, Westreich DJ, Steyn PS AIDS (London, England) 27500670 AIDS 2016 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/27500670
Commentary: Epidemiology in the era of big data. Mooney SJ, Westreich DJ, El-Sayed AM Epidemiology (Cambridge, Mass.) 25756221 Epidemiology 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25756221
Risk. Cole SR, Hudgens MG, Brookhart MA, Westreich D American journal of epidemiology 25660080 Am J Epidemiol 2015 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/25660080
The Authors Respond. Lesko CR, Buchanan AL, Westreich D, Edwards JK, Hudgens MG, Cole SR Epidemiology (Cambridge, Mass.) 29023242 Epidemiology 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29023242
Invited Commentary: Causal Inference Across Space and Time-Quixotic Quest, Worthy Goal, or Both? Edwards JK, Lesko CR, Keil AP American journal of epidemiology 28679174 Am J Epidemiol 2017 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/28679174
Primary non-adherence and the new-user design. Li X, Cole SR, Westreich D, Brookhart MA Pharmacoepidemiology and drug safety 29460385 Pharmacoepidemiol Drug Saf 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29460385
G-computation for policy-relevant effects of interventions on time-to-event outcomes. Breskin A, Edmonds A, Cole SR, Westreich D, Cocohoba J, Cohen MH, Kassaye SG, Metsch LR, Sharma A, Williams MS, Adimora AA International journal of epidemiology 33141177 Int J Epidemiol 2021 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/33141177
Exploring the Subtleties of Inverse Probability Weighting and Marginal Structural Models. Breskin A, Cole SR, Westreich D Epidemiology (Cambridge, Mass.) 29384789 Epidemiology 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29384789
RESOLVING AN APPARENT PARADOX IN DOUBLY ROBUST ESTIMATORS. Keil AP, Mooney SJ, Jonsson Funk M, Cole SR, Edwards JK, Westreich D American journal of epidemiology 29394330 Am J Epidemiol 2018 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/29394330
Two-stage g-computation: Evaluating Treatment and Intervention Impacts in Observational Cohorts When Exposure Information Is Partly Missing. Breger TL, Edwards JK, Cole SR, Westreich D, Pence BW, Adimora AA Epidemiology (Cambridge, Mass.) 32657953 Epidemiology 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32657953
Incident obstructive lung disease and mortality among people with HIV and a history of injecting drugs. Kalmin MM, Westreich D, Drummond BM, Sun J, Mehta SH, Kirk GD AIDS (London, England) 33831913 AIDS 2021 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/33831913
A longitudinal, HIV care continuum: 10-year restricted mean time in each care continuum stage after enrollment in care, by history of IDU. Lesko CR, Edwards JK, Moore RD, Lau B AIDS (London, England) 27314178 AIDS 2016 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/27314178
Effect of Postnatal HIV Treatment on Clinical Mastitis and Breast Inflammation in HIV-Infected Breast-feeding Women. Zadrozny S, Westreich D, Hudgens MG, Chasela C, Jamieson DJ, Martinson F, Zimba C, Tegha G, Hoffman I, Miller WC, Pence BW, King CC, Kourtis AP, Msungama W, van der Horst C, BAN Study Team Paediatric and perinatal epidemiology 28205255 Paediatr Perinat Epidemiol 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28205255
Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India. Rogawski ET, Westreich DJ, Adair LS, Becker-Dreps S, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick S, Kang G The Journal of pediatrics 26372535 J Pediatr 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26372535
Transportability of Trial Results Using Inverse Odds of Sampling Weights. Westreich D, Edwards JK, Lesko CR, Stuart E, Cole SR American journal of epidemiology 28535275 Am J Epidemiol 2017 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/28535275
Thirteen Questions About Using Machine Learning in Causal Research (You Won't Believe the Answer to Number 10!). Mooney SJ, Keil AP, Westreich DJ American journal of epidemiology 33751024 Am J Epidemiol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/33751024
Inverse Probability Weights for the Analysis of Polytomous Outcomes. Richardson DB, Kinlaw AC, Keil AP, Naimi AI, Kaufman JS, Cole SR American journal of epidemiology 29390115 Am J Epidemiol 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29390115
You are smarter than you think: (super) machine learning in context. Keil AP, Edwards JK European journal of epidemiology 29744711 Eur J Epidemiol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29744711
Age at Entry Into Care, Timing of Antiretroviral Therapy Initiation, and 10-Year Mortality Among HIV-Seropositive Adults in the United States. Edwards JK, Cole SR, Westreich D, Mugavero MJ, Eron JJ, Moore RD, Mathews WC, Hunt P, Williams C, Centers for AIDS Research Network of Integrated Clinical Systems investigators Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 26082505 Clin Infect Dis 2015 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/26082505
The Impact of Implementation Fidelity on Mortality Under a CD4-Stratified Timing Strategy for Antiretroviral Therapy in Patients With Tuberculosis. Patel MR, Westreich D, Yotebieng M, Nana M, Eron JJ, Behets F, Van Rie A American journal of epidemiology 25787266 Am J Epidemiol 2015 May 1 https://www.ncbi.nlm.nih.gov/pubmed/25787266
Misclassification in defining and diagnosing microcephaly. Kalmin MM, Gower EW, Stringer EM, Bowman NM, Rogawski McQuade ET, Westreich D Paediatric and perinatal epidemiology 31347726 Paediatr Perinat Epidemiol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31347726
The Intersections of COVID-19, HIV, and Race/Ethnicity: Machine Learning Methods to Identify and Model Risk Factors for Severe COVID-19 in a Large U.S. National Dataset. Kunz M, Rott KW, Hurwitz E, Kunisaki K, Sun J, Wilkins KJ, Islam JY, Patel R, Safo SE, National Covid Cohort Collaborative (N3C) Consortium AIDS and behavior 38326668 AIDS Behav 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38326668
Next-generation libraries for robust RNA interference-based genome-wide screens. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS Proceedings of the National Academy of Sciences of the United States of America 26080438 Proc Natl Acad Sci U S A 2015 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/26080438
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen. Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC Cell host & microbe 31540829 Cell Host Microbe 2019 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/31540829
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L Molecular cell 33171122 Mol Cell 2020 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/33171122
Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA Nucleic acids research 25270879 Nucleic Acids Res 2014 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/25270879
KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics. Milic B, Chakraborty A, Han K, Bassik MC, Block SM Proceedings of the National Academy of Sciences of the United States of America 29703754 Proc Natl Acad Sci U S A 2018 May 15 https://www.ncbi.nlm.nih.gov/pubmed/29703754
Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs. Lu A, Wawro P, Morgens DW, Portela F, Bassik MC, Pfeffer SR eLife 30556811 Elife 2018 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/30556811
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens. Morgens DW, Wainberg M, Boyle EA, Ursu O, Araya CL, Tsui CK, Haney MS, Hess GT, Han K, Jeng EE, Li A, Snyder MP, Greenleaf WJ, Kundaje A, Bassik MC Nature communications 28474669 Nat Commun 2017 May 5 https://www.ncbi.nlm.nih.gov/pubmed/28474669
An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. Coukos R, Yao D, Sanchez MI, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY eLife 34414886 Elife 2021 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/34414886
Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC eLife 31674906 Elife 2019 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/31674906
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Hess GT, Frésard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, Bassik MC Nature methods 27798611 Nat Methods 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27798611
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Liu N, Lee CH, Swigut T, Grow E, Gu B, Bassik MC, Wysocka J Nature 29211708 Nature 2018 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/29211708
A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. Gupta A, Ökesli-Armlovich A, Morgens D, Bassik MC, Khosla C The Journal of biological chemistry 31915244 J Biol Chem 2020 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/31915244
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes. Morgens DW, Deans RM, Li A, Bassik MC Nature biotechnology 27159373 Nat Biotechnol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27159373
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O Cell 30612740 Cell 2019 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/30612740
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages. Cohen A, Jeng EE, Voorhies M, Symington J, Ali N, Rodriguez RA, Bassik MC, Sil A PLoS pathogens 36174103 PLoS Pathog 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36174103
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia. Duque-Afonso J, Lin CH, Han K, Wei MC, Feng J, Kurzer JH, Schneidawind C, Wong SH, Bassik MC, Cleary ML Cancer research 27758892 Cancer Res 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27758892
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC Nature chemical biology 27018887 Nat Chem Biol 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27018887
Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy. Okesli A, Khosla C, Bassik MC Current opinion in biotechnology 28458037 Curr Opin Biotechnol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28458037
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS Cell 25307932 Cell 2014 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/25307932
SLC19A1 Is an Importer of the Immunotransmitter cGAMP. Ritchie C, Cordova AF, Hess GT, Bassik MC, Li L Molecular cell 31126740 Mol Cell 2019 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/31126740
Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway. Dubreuil MM, Morgens DW, Okumoto K, Honsho M, Contrepois K, Lee-McMullen B, Traber GM, Sood RS, Dixon SJ, Snyder MP, Fujiki Y, Bassik MC Cell reports 32023459 Cell Rep 2020 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/32023459
CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity. Tsui CK, Barfield RM, Fischer CR, Morgens DW, Li A, Smith BAH, Gray MA, Bertozzi CR, Rabuka D, Bassik MC Nature chemical biology 31451760 Nat Chem Biol 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31451760
A genome-wide atlas of co-essential modules assigns function to uncharacterized genes. Wainberg M, Kamber RA, Balsubramani A, Meyers RM, Sinnott-Armstrong N, Hornburg D, Jiang L, Chan J, Jian R, Gu M, Shcherbina A, Dubreuil MM, Spees K, Meuleman W, Snyder MP, Bassik MC, Kundaje A Nature genetics 33859415 Nat Genet 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33859415
Translation readthrough mitigation. Arribere JA, Cenik ES, Jain N, Hess GT, Lee CH, Bassik MC, Fire AZ Nature 27281202 Nature 2016 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/27281202
Unraveling the mechanism of cell death induced by chemical fibrils. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA Nature chemical biology 25262416 Nat Chem Biol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25262416
Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus. Leonardi W, Zilbermintz L, Cheng LW, Zozaya J, Tran SH, Elliott JH, Polukhina K, Manasherob R, Li A, Chi X, Gharaibeh D, Kenny T, Zamani R, Soloveva V, Haddow AD, Nasar F, Bavari S, Bassik MC, Cohen SN, Levitin A, Martchenko M Scientific reports 27686742 Sci Rep 2016 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/27686742
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Han K, Jeng EE, Hess GT, Morgens DW, Li A, Bassik MC Nature biotechnology 28319085 Nat Biotechnol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28319085
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis. Kamber RA, Nishiga Y, Morton B, Banuelos AM, Barkal AA, Vences-Catalán F, Gu M, Fernandez D, Seoane JA, Yao D, Liu K, Lin S, Spees K, Curtis C, Jerby-Arnon L, Weissman IL, Sage J, Bassik MC Nature 34497417 Nature 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34497417
SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Wang Z, Hausmann S, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK Cancer cell 32442403 Cancer Cell 2020 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/32442403
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes. Hess GT, Tycko J, Yao D, Bassik MC Molecular cell 28985508 Mol Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28985508
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC Nature 32238925 Nature 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32238925
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T Nature neuroscience 31959936 Nat Neurosci 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31959936
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD Nature genetics 29507424 Nat Genet 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29507424
A semi-supervised approach to extract pharmacogenomics-specific drug-gene pairs from biomedical literature for personalized medicine. Xu R, Wang Q Journal of biomedical informatics 23570835 J Biomed Inform 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23570835
Disease Comorbidity Network Guides the Detection of Molecular Evidence for the Link Between Colorectal Cancer and Obesity. Chen Y, Li L, Xu R AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 26306270 AMIA Jt Summits Transl Sci Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26306270
Phenome-driven disease genetics prediction toward drug discovery. Chen Y, Li L, Zhang GQ, Xu R Bioinformatics (Oxford, England) 26072493 Bioinformatics 2015 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/26072493
Analysis of disease organ as a novel phenotype towards disease genetics understanding. Luo L, Zheng C, Wang J, Tan M, Li Y, Xu R Journal of biomedical informatics 31207382 J Biomed Inform 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31207382
Combining mechanism-based prediction with patient-based profiling for psoriasis metabolomics biomarker discovery. Wang Q, McCormick TS, Ward NL, Cooper KD, Conic R, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 29854244 AMIA Annu Symp Proc 2017 https://www.ncbi.nlm.nih.gov/pubmed/29854244
Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment. Nagaraj AB, Wang QQ, Joseph P, Zheng C, Chen Y, Kovalenko O, Singh S, Armstrong A, Resnick K, Zanotti K, Waggoner S, Xu R, DiFeo A Oncogene 28967908 Oncogene 2018 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/28967908
Comparative analysis of a novel disease phenotype network based on clinical manifestations. Chen Y, Zhang X, Zhang GQ, Xu R Journal of biomedical informatics 25277758 J Biomed Inform 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25277758
Molecular subtyping of Alzheimer's disease with consensus non-negative matrix factorization. Zheng C, Xu R PloS one 34014928 PLoS One 2021 https://www.ncbi.nlm.nih.gov/pubmed/34014928
COVID-19 risk, disparities and outcomes in patients with chronic liver disease in the United States. Wang Q, Davis PB, Xu R EClinicalMedicine 33521611 EClinicalMedicine 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33521611
DenseCNN: A Densely Connected CNN Model for Alzheimer's Disease Classification Based on Hippocampus MRI Data. Wang Q, Li Y, Zheng C, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 33936504 AMIA Annu Symp Proc 2020 https://www.ncbi.nlm.nih.gov/pubmed/33936504
Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses. Zhou M, Wang Q, Zheng C, John Rush A, Volkow ND, Xu R Molecular psychiatry 33432189 Mol Psychiatry 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33432189
Predict Alzheimer's disease using hippocampus MRI data: a lightweight 3D deep convolutional network model with visual and global shape representations. Katabathula S, Wang Q, Xu R Alzheimer's research & therapy 34030743 Alzheimers Res Ther 2021 May 24 https://www.ncbi.nlm.nih.gov/pubmed/34030743
Association of Epigenetic Clock with Consensus Molecular Subtypes and Overall Survival of Colorectal Cancer. Zheng C, Li L, Xu R Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31375479 Cancer Epidemiol Biomarkers Prev 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31375479
Towards precision medicine-based therapies for glioblastoma: interrogating human disease genomics and mouse phenotypes. Chen Y, Gao Z, Wang B, Xu R BMC genomics 27557118 BMC Genomics 2016 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/27557118
Explore Small Molecule-induced Genome-wide Transcriptional Profiles for Novel Inflammatory Bowel Disease Drug. Cai X, Chen Y, Gao Z, Xu R AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 27570643 AMIA Jt Summits Transl Sci Proc 2016 https://www.ncbi.nlm.nih.gov/pubmed/27570643
Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis. Wang Q, Xu R BMC genomics 30744546 BMC Genomics 2019 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/30744546
Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study. Ding P, Gorenflo MP, Zhu X, Xu R Journal of Alzheimer's disease : JAD 36846997 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/36846997
A knowledge graph-based disease-gene prediction system using multi-relational graph convolution networks. Gao Z, Pan Y, Ding P, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 37128437 AMIA Annu Symp Proc 2022 https://www.ncbi.nlm.nih.gov/pubmed/37128437
Association of COVID-19 with Risk and Progression of Alzheimer's Disease: Non-Overlapping Two-Sample Mendelian Randomization Analysis of 2.6 Million Subjects. Ding P, Gurney M, Perry G, Xu R Journal of Alzheimer's disease : JAD 38007657 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/38007657
Association of semaglutide with risk of suicidal ideation in a real-world cohort. Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R Nature medicine 38182782 Nat Med 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38182782
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models. Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X Nature communications 35236834 Nat Commun 2022 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/35236834
A Drug-Side Effect Context-Sensitive Network approach for drug target prediction. Zhou M, Chen Y, Xu R Bioinformatics (Oxford, England) 30428013 Bioinformatics 2019 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/30428013
Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson's disease. Chen Y, Cai X, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 26958284 AMIA Annu Symp Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26958284
MetabolitePredict: A de novo human metabolomics prediction system and its applications in rheumatoid arthritis. Wang Q, Xu R Journal of biomedical informatics 28600026 J Biomed Inform 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28600026
Drug repurposing for glioblastoma based on molecular subtypes. Chen Y, Xu R Journal of biomedical informatics 27697594 J Biomed Inform 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27697594
Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS). Xu R, Wang Q Journal of biomedical informatics 24177320 J Biomed Inform 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24177320
Large-scale automatic extraction of side effects associated with targeted anticancer drugs from full-text oncological articles. Xu R, Wang Q Journal of biomedical informatics 25817969 J Biomed Inform 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25817969
A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat. Xu R, Wang Q, Li L BMC genomics 26100814 BMC Genomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26100814
PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery. Xu R, Wang Q Journal of biomedical informatics 26151312 J Biomed Inform 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26151312
Combining automatic table classification and relationship extraction in extracting anticancer drug-side effect pairs from full-text articles. Xu R, Wang Q Journal of biomedical informatics 25445920 J Biomed Inform 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25445920
Drug repositioning for prostate cancer: using a data-driven approach to gain new insights. Wang Q, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 29854243 AMIA Annu Symp Proc 2017 https://www.ncbi.nlm.nih.gov/pubmed/29854243
A systems biology approach to predict and characterize human gut microbial metabolites in colorectal cancer. Wang Q, Li L, Xu R Scientific reports 29670137 Sci Rep 2018 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/29670137
Automatic extraction, prioritization and analysis of gut microbial metabolites from biomedical literature. Wang Q, Xu R Scientific reports 32561832 Sci Rep 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32561832
Correction: COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States. Wang QQ, Kaelber DC, Xu R, Volkow ND Molecular psychiatry 32999436 Mol Psychiatry 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32999436
COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States. Wang QQ, Kaelber DC, Xu R, Volkow ND Molecular psychiatry 32929211 Mol Psychiatry 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32929211
Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer's disease in patients with rheumatoid arthritis and psoriasis. Zhou M, Xu R, Kaelber DC, Gurney ME PloS one 32203525 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/32203525
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X Acta neuropathologica 36104602 Acta Neuropathol 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36104602
Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease. Tun X, Wang EJ, Gao Z, Lundberg K, Xu R, Hu D International journal of molecular sciences 36982771 Int J Mol Sci 2023 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/36982771
GLP-1 Receptor Agonists and Colorectal Cancer Risk in Drug-Naive Patients With Type 2 Diabetes, With and Without Overweight/Obesity. Wang L, Wang W, Kaelber DC, Xu R, Berger NA JAMA oncology 38060218 JAMA Oncol 2024 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/38060218
An iterative searching and ranking algorithm for prioritising pharmacogenomics genes. Xu R, Wang Q International journal of computational biology and drug design 23428471 Int J Comput Biol Drug Des 2013 https://www.ncbi.nlm.nih.gov/pubmed/23428471
Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer. Belur Nagaraj A, Joseph P, Kovalenko O, Wang Q, Xu R, DiFeo A Gynecologic oncology 30301560 Gynecol Oncol 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30301560
Towards understanding brain-gut-microbiome connections in Alzheimer's disease. Xu R, Wang Q BMC systems biology 27585440 BMC Syst Biol 2016 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/27585440
Automatic construction of a large-scale and accurate drug-side-effect association knowledge base from biomedical literature. Xu R, Wang Q Journal of biomedical informatics 24928448 J Biomed Inform 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24928448
DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue. Wang Q, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 26958268 AMIA Annu Symp Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26958268
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X Science advances 33277246 Sci Adv 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33277246
COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US. Wang Q, Davis PB, Gurney ME, Xu R Alzheimer's & dementia : the journal of the Alzheimer's Association 33559975 Alzheimers Dement 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33559975
When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities. Wang Q, Berger NA, Xu R Blood reviews 33187811 Blood Rev 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33187811
Disease comorbidity-guided drug repositioning: a case study in schizophrenia. Wang Q, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 30815174 AMIA Annu Symp Proc 2018 https://www.ncbi.nlm.nih.gov/pubmed/30815174
Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization. Wang Q, Davis PB, Qi X, Chen SG, Gurney ME, Perry G, Doraiswamy PM, Xu R Alzheimer's research & therapy 34670619 Alzheimers Res Ther 2021 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/34670619
Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes. Wang L, Xu R, Kaelber DC, Berger NA JAMA network open 38967919 JAMA Netw Open 2024 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/38967919
Sex-Specific Heterogeneity of Mild Cognitive Impairment Identified Based on Multi-Modal Data Analysis. Katabathula S, Davis PB, Xu R, Alzheimer’s Disease Neuroimaging Initiative Journal of Alzheimer's disease : JAD 36404544 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/36404544
A genomics-based systems approach towards drug repositioning for rheumatoid arthritis. Xu R, Wang Q BMC genomics 27557330 BMC Genomics 2016 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/27557330
Phenome-based gene discovery provides information about Parkinson's disease drug targets. Chen Y, Xu R BMC genomics 27586503 BMC Genomics 2016 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/27586503
Predict drug permeability to blood-brain-barrier from clinical phenotypes: drug side effects and drug indications. Gao Z, Chen Y, Cai X, Xu R Bioinformatics (Oxford, England) 27993785 Bioinformatics 2017 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/27993785
Context-sensitive network-based disease genetics prediction and its implications in drug discovery. Chen Y, Xu R Bioinformatics (Oxford, England) 28062449 Bioinformatics 2017 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/28062449
Interrogating Patient-level Genomics and Mouse Phenomics towards Understanding Cytokines in Colorectal Cancer Metastasis. Cai X, Chen Y, Zheng C, Xu R AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 28815134 AMIA Jt Summits Transl Sci Proc 2017 https://www.ncbi.nlm.nih.gov/pubmed/28815134
Network-based gene prediction for Plasmodium falciparum malaria towards genetics-based drug discovery. Chen Y, Xu R BMC genomics 26099491 BMC Genomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26099491
Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans. Zheng C, Fillmore NR, Ramos-Cejudo J, Brophy M, Osorio R, Gurney ME, Qiu WQ, Au R, Perry G, Dubreuil M, Chen SG, Qi X, Davis PB, Do N, Xu R Alzheimer's & dementia : the journal of the Alzheimer's Association 34569707 Alzheimers Dement 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/34569707
CoMNRank: An integrated approach to extract and prioritize human microbial metabolites from MEDLINE records. Wang Q, Xu R Journal of biomedical informatics 32791237 J Biomed Inform 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32791237
Epigenetic age acceleration and clinical outcomes in gliomas. Zheng C, Berger NA, Li L, Xu R PloS one 32692766 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/32692766
Predicting cancer origins with a DNA methylation-based deep neural network model. Zheng C, Xu R PloS one 32384093 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/32384093
tcTKB: an integrated cardiovascular toxicity knowledge base for targeted cancer drugs. Xu R, Wang Q AMIA ... Annual Symposium proceedings. AMIA Symposium 26958275 AMIA Annu Symp Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26958275
Large-scale mining disease comorbidity relationships from post-market drug adverse events surveillance data. Zheng C, Xu R BMC bioinformatics 30591027 BMC Bioinformatics 2018 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/30591027
An iterative approach to detect pleiotropy and perform Mendelian Randomization analysis using GWAS summary statistics. Zhu X, Li X, Xu R, Wang T Bioinformatics (Oxford, England) 33226062 Bioinformatics 2021 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/33226062
Immunotherapy-related adverse events (irAEs): extraction from FDA drug labels and comparative analysis. Wang Q, Xu R JAMIA open 30976759 JAMIA Open 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30976759
Combining phenome-driven drug-target interaction prediction with patients' electronic health records-based clinical corroboration toward drug discovery. Zhou M, Zheng C, Xu R Bioinformatics (Oxford, England) 32657406 Bioinformatics 2020 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/32657406
Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume. Conic RR, Damiani G, Schrom KP, Ramser AE, Zheng C, Xu R, McCormick TS, Cooper KD Journal of clinical medicine 31936662 J Clin Med 2020 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/31936662
Context-sensitive network analysis identifies food metabolites associated with Alzheimer's disease: an exploratory study. Chen Y, Xu R BMC medical genomics 30704467 BMC Med Genomics 2019 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/30704467
The Alzheimer's comorbidity phenome: mining from a large patient database and phenome-driven genetics prediction. Zheng C, Xu R JAMIA open 30944912 JAMIA Open 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30944912
Glucagon-like peptide-1 receptor agonists and pancreatic cancer risk: target trial emulation using real-world data. Wang L, Wang Q, Li L, Kaelber DC, Xu R Journal of the National Cancer Institute 39418202 J Natl Cancer Inst 2025 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/39418202
Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study. Ding P, Xu R Journal of the neurological sciences 37925898 J Neurol Sci 2023 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/37925898
Association of Aspirin Use with Reduced Risk of Developing Alzheimer's Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study. Gorenflo MP, Davis PB, Kendall EK, Olaker VR, Kaelber DC, Xu R Journal of Alzheimer's disease : JAD 36502331 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/36502331
Comorbidity-driven multi-modal subtype analysis in mild cognitive impairment of Alzheimer's disease. Katabathula S, Davis PB, Xu R Alzheimer's & dementia : the journal of the Alzheimer's Association 36166485 Alzheimers Dement 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36166485
Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine. Jensen G, Holloway JL, Stabenfeldt SE Cells 32957463 Cells 2020 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/32957463
Sex-Dependent Macromolecule and Nanoparticle Delivery in Experimental Brain Injury. Bharadwaj VN, Copeland C, Mathew E, Newbern J, Anderson TR, Lifshitz J, Kodibagkar VD, Stabenfeldt SE Tissue engineering. Part A 32697674 Tissue Eng Part A 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32697674
Temporal assessment of nanoparticle accumulation after experimental brain injury: Effect of particle size. Bharadwaj VN, Lifshitz J, Adelson PD, Kodibagkar VD, Stabenfeldt SE Scientific reports 27444615 Sci Rep 2016 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/27444615
Tunable Controlled Release of Bioactive SDF-1α via Protein Specific Interactions within Fibrin/Nanoparticle Composites. Dutta D, Fauer C, Mulleneux HL, Stabenfeldt SE Journal of materials chemistry. B 26660666 J Mater Chem B 2015 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/26660666
Blood-brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury. Bharadwaj VN, Rowe RK, Harrison J, Wu C, Anderson TR, Lifshitz J, Adelson PD, Kodibagkar VD, Stabenfeldt SE Nanomedicine : nanotechnology, biology, and medicine 29933022 Nanomedicine 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29933022
pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma. Householder KT, DiPerna DM, Chung EP, Luning AR, Nguyen DT, Stabenfeldt SE, Mehta S, Sirianni RW Colloids and surfaces. B, Biointerfaces 29533842 Colloids Surf B Biointerfaces 2018 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/29533842
Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain. Hickey KN, Grassi SM, Caplan MR, Stabenfeldt SE Cellular and molecular bioengineering 33643467 Cell Mol Bioeng 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33643467
Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1α. Addington CP, Dharmawaj S, Heffernan JM, Sirianni RW, Stabenfeldt SE Matrix biology : journal of the International Society for Matrix Biology 27645115 Matrix Biol 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/27645115
Endogenous repair signaling after brain injury and complementary bioengineering approaches to enhance neural regeneration. Addington CP, Roussas A, Dutta D, Stabenfeldt SE Biomarker insights 25983552 Biomark Insights 2015 https://www.ncbi.nlm.nih.gov/pubmed/25983552
In Vivo Phage Display as a Biomarker Discovery Tool for the Complex Neural Injury Microenvironment. Martinez BI, Stabenfeldt SE Current protocols 33625787 Curr Protoc 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33625787
Siloxane Nanoprobes for Labeling and Dual Modality Functional Imaging of Neural Stem Cells. Addington CP, Cusick A, Shankar RV, Agarwal S, Stabenfeldt SE, Kodibagkar VD Annals of biomedical engineering 26597417 Ann Biomed Eng 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26597417
Nanoparticle-Based Therapeutics for Brain Injury. Bharadwaj VN, Nguyen DT, Kodibagkar VD, Stabenfeldt SE Advanced healthcare materials 29034608 Adv Healthc Mater 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29034608
Exploiting Phage Display for Development of Novel Cellular Targeting Strategies. Marsh W, Witten A, Stabenfeldt SE Methods in molecular biology (Clifton, N.J.) 30051426 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30051426
Enhancing neural stem cell response to SDF-1α gradients through hyaluronic acid-laminin hydrogels. Addington CP, Heffernan JM, Millar-Haskell CS, Tucker EW, Sirianni RW, Stabenfeldt SE Biomaterials 26340314 Biomaterials 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26340314
Tunable delayed controlled release profile from layered polymeric microparticles. Dutta D, Fauer C, Hickey K, Salifu M, Stabenfeldt SE Journal of materials chemistry. B 28652916 J Mater Chem B 2017 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/28652916
Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex. Dutta D, Hickey K, Salifu M, Fauer C, Willingham C, Stabenfeldt SE Biomaterials science 28703822 Biomater Sci 2017 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/28703822
Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen. Brown AC, Lavik E, Stabenfeldt SE Bioconjugate chemistry 31246419 Bioconjug Chem 2019 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/31246419
Leveraging the Dynamic Blood-Brain Barrier for Central Nervous System Nanoparticle-based Drug Delivery Applications. Copeland C, Stabenfeldt SE Current opinion in biomedical engineering 32432210 Curr Opin Biomed Eng 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32432210
Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury. Todd J, Bharadwaj VN, Nellenbach K, Nandi S, Mihalko E, Copeland C, Brown AC, Stabenfeldt SE Journal of biomedical materials research. Part B, Applied biomaterials 34117693 J Biomed Mater Res B Appl Biomater 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34117693
GdDO3NI Enhanced Magnetic Resonance Imaging Allows Imaging of Hypoxia After Brain Injury. Moghadas B, Bharadwaj VN, Tobey JP, Tian Y, Stabenfeldt SE, Kodibagkar VD Journal of magnetic resonance imaging : JMRI 34499791 J Magn Reson Imaging 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/34499791
Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning. Dutta D, Salifu M, Sirianni RW, Stabenfeldt SE Journal of biomedical materials research. Part A 26517011 J Biomed Mater Res A 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26517011
Using biomaterials to modulate chemotactic signaling for central nervous system repair. Hickey K, Stabenfeldt SE Biomedical materials (Bristol, England) 29411713 Biomed Mater 2018 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/29411713
Current trends in biomarker discovery and analysis tools for traumatic brain injury. Martinez BI, Stabenfeldt SE Journal of biological engineering 30828380 J Biol Eng 2019 https://www.ncbi.nlm.nih.gov/pubmed/30828380
Uncovering temporospatial sensitive TBI targeting strategies via in vivo phage display. Martinez BI, Mousa GA, Fleck K, MacCulloch T, Diehnelt CW, Stephanopoulos N, Stabenfeldt SE Science advances 35867794 Sci Adv 2022 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/35867794
Solid phase chemistry to covalently and reversibly capture thiolated RNA. Duffy EE, Canzio D, Maniatis T, Simon MD Nucleic acids research 29986098 Nucleic Acids Res 2018 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/29986098
m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z, Flavell RA Nature 28792938 Nature 2017 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/28792938
Catching RNAs on chromatin using hybridization capture methods. Machyna M, Simon MD Briefings in functional genomics 29126220 Brief Funct Genomics 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29126220
Expanding the Nucleoside Recoding Toolkit: Revealing RNA Population Dynamics with 6-Thioguanosine. Kiefer L, Schofield JA, Simon MD Journal of the American Chemical Society 30353734 J Am Chem Soc 2018 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/30353734
Enriching s(4) U-RNA Using Methane Thiosulfonate (MTS) Chemistry. Duffy EE, Simon MD Current protocols in chemical biology 27925666 Curr Protoc Chem Biol 2016 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/27925666
The NBDY Microprotein Regulates Cellular RNA Decapping. Na Z, Luo Y, Schofield JA, Smelyansky S, Khitun A, Muthukumar S, Valkov E, Simon MD, Slavoff SA Biochemistry 33059440 Biochemistry 2020 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/33059440
Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. Luo Y, Schofield JA, Na Z, Hann T, Simon MD, Slavoff SA Cell chemical biology 33357462 Cell Chem Biol 2021 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/33357462
The Properties of Long Noncoding RNAs That Regulate Chromatin. Rutenberg-Schoenberg M, Sexton AN, Simon MD Annual review of genomics and human genetics 27147088 Annu Rev Genomics Hum Genet 2016 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/27147088
Tracking Distinct RNA Populations Using Efficient and Reversible Covalent Chemistry. Duffy EE, Rutenberg-Schoenberg M, Stark CD, Kitchen RR, Gerstein MB, Simon MD Molecular cell 26340425 Mol Cell 2015 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/26340425
TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding. Schofield JA, Duffy EE, Kiefer L, Sullivan MC, Simon MD Nature methods 29355846 Nat Methods 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29355846
STL-seq reveals pause-release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts. Zimmer JT, Rosa-Mercado NA, Canzio D, Steitz JA, Simon MD Molecular cell 34520723 Mol Cell 2021 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/34520723
Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, Kiefer L, Simon MD Nature structural & molecular biology 32157249 Nat Struct Mol Biol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32157249
Acetyl-methyllysine marks chromatin at active transcription start sites. Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD Nature 37731000 Nature 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37731000
Insight into lncRNA biology using hybridization capture analyses. Simon MD Biochimica et biophysica acta 26381323 Biochim Biophys Acta 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26381323
Probing Xist RNA Structure in Cells Using Targeted Structure-Seq. Fang R, Moss WN, Rutenberg-Schoenberg M, Simon MD PLoS genetics 26646615 PLoS Genet 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26646615
Interpreting Reverse Transcriptase Termination and Mutation Events for Greater Insight into the Chemical Probing of RNA. Sexton AN, Wang PY, Rutenberg-Schoenberg M, Simon MD Biochemistry 28820243 Biochemistry 2017 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/28820243
Global Profiling of Cellular Substrates of Human Dcp2. Luo Y, Schofield JA, Simon MD, Slavoff SA Biochemistry 32365300 Biochemistry 2020 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/32365300
Stella's Role in Oocyte DNA Methylation Suggests Additional Activities of DNMT1. Kiefer L, Simon MD Biochemistry 30920202 Biochemistry 2019 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/30920202
Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice. Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T Cell 30955885 Cell 2019 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/30955885
Carbodiimide reagents for the chemical probing of RNA structure in cells. Wang PY, Sexton AN, Culligan WJ, Simon MD RNA (New York, N.Y.) 30389828 RNA 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30389828
Gaining insight into transcriptome-wide RNA population dynamics through the chemistry of 4-thiouridine. Duffy EE, Schofield JA, Simon MD Wiley interdisciplinary reviews. RNA 30370679 Wiley Interdiscip Rev RNA 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30370679
Internally controlled RNA sequencing comparisons using nucleoside recoding chemistry. Courvan MCS, Niederer RO, Vock IW, Kiefer L, Gilbert WV, Simon MD Nucleic acids research 36018791 Nucleic Acids Res 2022 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/36018791
Epithelial Cell Chirality Revealed by Three-Dimensional Spontaneous Rotation. Chin AS, Worley KE, Ray P, Kaur G, Fan J, Wan LQ Proceedings of the National Academy of Sciences of the United States of America 30429314 Proc Natl Acad Sci U S A 2018 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/30429314
Cell Chirality as a Novel Measure for Cytotoxicity. Zhang H, Wan LQ Advanced biology 34796704 Adv Biol (Weinh) 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34796704
Cell jamming regulates epithelial chiral morphogenesis. Rahman T, Peters F, Wan LQ Journal of biomechanics 36641827 J Biomech 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36641827
A Micropatterning Assay for Measuring Cell Chirality. Zhang H, Ronaldson-Bouchard K, Vunjak-Novakovic G, Wan LQ Journal of visualized experiments : JoVE 35343954 J Vis Exp 2022 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/35343954
Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality. Raymond MJ Jr, Ray P, Kaur G, Fredericks M, Singh AV, Wan LQ Cellular and molecular bioengineering 28360944 Cell Mol Bioeng 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/28360944
Teratogen screening with human pluripotent stem cells. Worley KE, Rico-Varela J, Ho D, Wan LQ Integrative biology : quantitative biosciences from nano to macro 30095839 Integr Biol (Camb) 2018 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/30095839
Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality. Raymond MJ Jr, Ray P, Kaur G, Singh AV, Wan LQ Annals of biomedical engineering 26294010 Ann Biomed Eng 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26294010
Cell chirality in cardiovascular development and disease. Rahman T, Zhang H, Fan J, Wan LQ APL bioengineering 32903894 APL Bioeng 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32903894
Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation. Worley KE, Chin AS, Wan LQ Stem cells international 30627170 Stem Cells Int 2018 https://www.ncbi.nlm.nih.gov/pubmed/30627170
Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping. Ray P, Chin AS, Worley KE, Fan J, Kaur G, Wu M, Wan LQ Proceedings of the National Academy of Sciences of the United States of America 30459275 Proc Natl Acad Sci U S A 2018 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/30459275
Cell chirality regulates intercellular junctions and endothelial permeability. Fan J, Ray P, Lu YW, Kaur G, Schwarz JJ, Wan LQ Science advances 30397640 Sci Adv 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30397640
Cell chirality: emergence of asymmetry from cell culture. Wan LQ, Chin AS, Worley KE, Ray P Philosophical transactions of the Royal Society of London. Series B, Biological sciences 27821525 Philos Trans R Soc Lond B Biol Sci 2016 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/27821525
In Vitro Microscale Models for Embryogenesis. Rico-Varela J, Ho D, Wan LQ Advanced biosystems 30533517 Adv Biosyst 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/30533517
Cell organelle-based analysis of cell chirality. Fan J, Zhang H, Rahman T, Stanton DN, Wan LQ Communicative & integrative biology 31143366 Commun Integr Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31143366
The Actin Crosslinker Fascin Regulates Cell Chirality. Zhang H, Fan J, Maclin JMA, Wan LQ Advanced biology 36658789 Adv Biol (Weinh) 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/36658789
Helical vasculogenesis driven by cell chirality. Zhang H, Rahman T, Lu S, Adam AP, Wan LQ Science advances 38381835 Sci Adv 2024 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/38381835
Enhanced fitness of adult spermatogonial stem cells bearing a paternal age-associated FGFR2 mutation. Martin LA, Assif N, Gilbert M, Wijewarnasuriya D, Seandel M Stem cell reports 25254335 Stem Cell Reports 2014 Aug 12 https://www.ncbi.nlm.nih.gov/pubmed/25254335
Faithful Artificial Chromosome Propagation Using Spermatogonial Stem Cells. Yamada M, Seandel M Trends in genetics : TIG 29107344 Trends Genet 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29107344
Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture†. N'Tumba-Byn T, Yamada M, Seandel M Biology of reproduction 31836902 Biol Reprod 2020 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/31836902
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells. Liu Y, Giannopoulou EG, Wen D, Falciatori I, Elemento O, Allis CD, Rafii S, Seandel M Nature communications 27117588 Nat Commun 2016 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/27117588
Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors. Sachs C, Robinson BD, Andres Martin L, Webster T, Gilbert M, Lo HY, Rafii S, Ng CK, Seandel M Andrology 24902969 Andrology 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24902969
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Male germ cells support long-term propagation of Zika virus. Robinson CL, Chong ACN, Ashbrook AW, Jeng G, Jin J, Chen H, Tang EI, Martin LA, Kim RS, Kenyon RM, Do E, Luna JM, Saeed M, Zeltser L, Ralph H, Dudley VL, Goldstein M, Rice CM, Cheng CY, Seandel M, Chen S Nature communications 29844387 Nat Commun 2018 May 29 https://www.ncbi.nlm.nih.gov/pubmed/29844387
Functional robustness of adult spermatogonial stem cells after induction of hyperactive Hras. Yamada M, Cai W, Martin LA, N'Tumba-Byn T, Seandel M PLoS genetics 31050682 PLoS Genet 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31050682
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Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC Journal of orthopaedic research : official publication of the Orthopaedic Research Society 27699833 J Orthop Res 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27699833
Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution. Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ Cell systems 35863345 Cell Syst 2022 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/35863345
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Mysteries in a Minimal Genome. Coyle M, Hu J, Gartner Z ACS central science 27280161 ACS Cent Sci 2016 May 25 https://www.ncbi.nlm.nih.gov/pubmed/27280161
Compact and modular multicolour fluorescence detector for droplet microfluidics. Cole RH, de Lange N, Gartner ZJ, Abate AR Lab on a chip 26032595 Lab Chip 2015 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/26032595
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Probing the luminal microenvironment of reconstituted epithelial microtissues. Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner ZJ, Desai TA Scientific reports 27619235 Sci Rep 2016 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/27619235
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Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission. Fan Q, Nelson CS, Bialas KM, Chiuppesi F, Amos J, Gurley TC, Marshall DJ, Eudailey J, Heimsath H, Himes J, Deshpande A, Walter MR, Wussow F, Diamond DJ, Barry PA, Moody MA, Kaur A, Permar SR Clinical and vaccine immunology : CVI 28298291 Clin Vaccine Immunol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28298291
Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants. Martinez DR, Tu JJ, Kumar A, Mangold JF, Mangan RJ, Goswami R, Giorgi EE, Chen J, Mengual M, Douglas AO, Heimsath H, Saunders KO, Nicely NI, Eudailey J, Hernandez G, Morgan-Asiedu PK, Wiehe K, Haynes BF, Moody MA, LaBranche C, Montefiori DC, Gao F, Permar SR mBio 32156815 mBio 2020 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/32156815
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A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. Jena PV, Roxbury D, Galassi TV, Akkari L, Horoszko CP, Iaea DB, Budhathoki-Uprety J, Pipalia N, Haka AS, Harvey JD, Mittal J, Maxfield FR, Joyce JA, Heller DA ACS nano 28898055 ACS Nano 2017 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/28898055
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A Fluorescent Carbon Nanotube Sensor Detects the Metastatic Prostate Cancer Biomarker uPA. Williams RM, Lee C, Heller DA ACS sensors 30169018 ACS Sens 2018 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/30169018
Optical Voltammetry of Polymer-Encapsulated Single-Walled Carbon Nanotubes. Horoszko CP, Jena PV, Roxbury D, Rotkin SV, Heller DA The journal of physical chemistry. C, Nanomaterials and interfaces 32690989 J Phys Chem C Nanomater Interfaces 2019 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/32690989
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Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation. Roxbury D, Jena PV, Shamay Y, Horoszko CP, Heller DA ACS nano 26654246 ACS Nano 2016 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/26654246
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A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway. Budhathoki-Uprety J, Langenbacher RE, Jena PV, Roxbury D, Heller DA ACS nano 28398031 ACS Nano 2017 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/28398031
Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes. Langenbacher R, Budhathoki-Uprety J, Jena PV, Roxbury D, Streit J, Zheng M, Heller DA Nano letters 34296885 Nano Lett 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34296885
Pollen grains as a novel microcarrier for oral delivery of proteins. Lale SV, Gill HS International journal of pharmaceutics 30308271 Int J Pharm 2018 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/30308271
Role of Sporopollenin Shell Interfacial Properties in Protein Adsorption. Uddin MJ, Liyanage S, Warzywoda J, Abidi N, Gill HS Langmuir : the ACS journal of surfaces and colloids 35212551 Langmuir 2022 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/35212551
From allergen to oral vaccine carrier: A new face of ragweed pollen. Uddin MJ, Gill HS International journal of pharmaceutics 29729407 Int J Pharm 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29729407
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A chemical treatment method for obtaining clean and intact pollen shells of different species. Gonzalez-Cruz P, Uddin MJ, Atwe SU, Abidi N, Gill HS ACS biomaterials science & engineering 31106262 ACS Biomater Sci Eng 2018 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/31106262
Demystifying particle-based oral vaccines. Gonzalez-Cruz P, Gill HS Expert opinion on drug delivery 34148474 Expert Opin Drug Deliv 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34148474
Physical and Biochemical Characterization of Chemically Treated Pollen Shells for Potential Use in Oral Delivery of Therapeutics. Uddin MJ, Liyanage S, Abidi N, Gill HS Journal of pharmaceutical sciences 30096353 J Pharm Sci 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30096353
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Multidimensional third-generation sequencing of modified DNA bases allows interrogation of complex biological systems. David SS, Pacheco BA, Kishimoto K, Vantine S, Hu K, Liu H, Davis DL, Tran H, Sallis BF, Ali L, Haynes CM, McCormick BA, Zhu LJ, Flavahan WA Nature communications 40593667 Nat Commun 2025 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/40593667
Regulatable assembly of synthetic microtubule architectures using engineered MAP-IDR condensates. Chang CC, Coyle SM bioRxiv : the preprint server for biology 38105997 bioRxiv 2023 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/38105997
Genetically encoded protein oscillators for FM streaming of single-cell data. Rajasekaran R, Galateo TM, Xu Z, Bolshakov DT, Weix EWZ, Coyle SM bioRxiv : the preprint server for biology 40060462 bioRxiv 2025 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/40060462
Comparative profiling of cellular gait on adhesive micropatterns defines statistical patterns of activity that underlie native and cancerous cell dynamics. Ahn JC, Coyle SM bioRxiv : the preprint server for biology 37961146 bioRxiv 2023 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/37961146
Noise-guided tuning of synthetic protein waves in living cells. Bolshakov DT, Weix EWZ, Galateo TM, Rajasekaran R, Coyle SM bioRxiv : the preprint server for biology 40166177 bioRxiv 2025 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/40166177
Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization. Xu Z, Chang CC, Coyle SM Physiology (Bethesda, Md.) 39938118 Physiology (Bethesda) 2025 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/39938118
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A mitochondrial redox switch licenses the onset of morphogenesis in animals. Kahlon U, Ricca FD, Pillai SJ, Olivetta M, Tharp KM, Jao LE, Dudin O, McDonald K, Aydogan MG bioRxiv : the preprint server for biology 39553983 bioRxiv 2024 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/39553983
Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes. Bakshi A, Iturra FE, Alamban A, Rosas-Salvans M, Dumont S, Aydogan MG Cell 37832525 Cell 2023 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/37832525
Dissecting host-microbe interactions with modern functional genomics. Russell BJ, Verma M, Maier NK, Jost M Current opinion in microbiology 39368241 Curr Opin Microbiol 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39368241
Comprehensive interrogation of synthetic lethality in the DNA damage response. Fielden J, Siegner SM, Gallagher DN, Schröder MS, Dello Stritto MR, Lam S, Kobel L, Schlapansky MF, Jackson SP, Cejka P, Jost M, Corn JE Nature 40205037 Nature 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/40205037
Engineering Tripartite Gene Editing Machinery for Highly Efficient Non-Viral Targeted Genome Integration. Nam H, Xie K, Majumdar I, Yang S, Starzyk J, Lee D, Shan R, Li J, Wu H Research square 37961210 Res Sq 2023 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/37961210
A New Bacterial Chassis for Enhanced Surface Display of Recombinant Proteins. Zhang R, Ye N, Wang Z, Yang S, Li J Cellular and molecular bioengineering 39513006 Cell Mol Bioeng 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39513006
Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses. Yang S, Sheffer M, Kaplan IE, Wang Z, Tarannum M, Dinh K, Abdulhamid Y, Bobilev E, Shapiro R, Porter R, Soiffer R, Ritz J, Koreth J, Wei Y, Chen P, Zhang K, Márquez-Pellegrin V, Bonanno S, Joshi N, Guan M, Yang M, Li D, Bellini C, Liu F, Chen J, Wu CJ, Barbie D, Li J, Romee R Nature biotechnology 39367093 Nat Biotechnol 2024 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/39367093
Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy. Yang S, Sheffer M, Kaplan IE, Wang Z, Tarannum M, Dinh K, Abdulhamid Y, Shapiro R, Porter R, Soiffer R, Ritz J, Koreth J, Wei Y, Chen P, Zhang K, Márquez-Pellegrin V, Bonanno S, Joshi N, Guan M, Yang M, Li D, Bellini C, Chen J, Wu CJ, Barbie D, Li J, Romee R Research square 38562821 Res Sq 2024 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/38562821
Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate. Yang M, Hutchinson N, Ye N, Timek H, Jennings M, Yin J, Guan M, Wang Z, Chen P, Yang S, Crane JD, Zhang K, He X, Li J ACS synthetic biology 39739838 ACS Synth Biol 2025 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/39739838
Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration. Nam H, Xie K, Majumdar I, Wang J, Yang S, Starzyk J, Lee D, Shan R, Li J, Wu H Nature communications 40379664 Nat Commun 2025 May 16 https://www.ncbi.nlm.nih.gov/pubmed/40379664
Squeezable Hydrogel Microparticles for Single Extracellular Vesicle Protein Profiling. Roh YH, Morales RT, Huynh E, Chintapula U, Reynolds DE, Agosto-Nieves RJ, Oh D, Seiner AJ, Lim J, Rodell CB, Ko J Small (Weinheim an der Bergstrasse, Germany) 39468876 Small 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39468876
Enhancing Chimeric Antigen Receptor T-Cell Generation via Microfluidic Mechanoporation and Lipid Nanoparticles. Lim J, Oh D, Cheng M, Chintapula U, Liu S, Reynolds D, Zhang X, Zhou Y, Xu X, Ko J Small (Weinheim an der Bergstrasse, Germany) 40103509 Small 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/40103509
Vertically Aligned Nanowires for Longitudinal Intracellular Sampling. Reynolds DE, Roh YH, Chintapula U, Huynh E, Vallapureddy P, Tran HH, Lee D, Allen MG, Xu X, Ko J ACS nano 40146010 ACS Nano 2025 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/40146010
Targeted protein relocalization via protein transport coupling. Ng CSC, Liu A, Cui B, Banik SM Nature 39294374 Nature 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39294374
Self-Assembled Nanocoatings Protect Microbial Fertilizers for Climate-Resilient Agriculture. Burke B, Fan G, Wasuwanich P, Moore EB, Furst AL JACS Au 38034965 JACS Au 2023 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/38034965
Transferrin receptor targeting chimeras for membrane protein degradation. Zhang D, Duque-Jimenez J, Facchinetti F, Brixi G, Rhee K, Feng WW, Jänne PA, Zhou X Nature 39322661 Nature 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39322661
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA. Ranzau BL, Robinson TD, Scully JM, Kapelczack ED, Dean TS, TeSlaa T, Schmitt DL bioRxiv : the preprint server for biology 39386450 bioRxiv 2024 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/39386450
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA. Ranzau BL, Robinson TD, Scully JM, Kapelczak ED, Dean TS, TeSlaa T, Schmitt DL ACS bio & med chem Au 39990938 ACS Bio Med Chem Au 2025 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/39990938
Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability. Bai D, Cao Z, Attada N, Song J, Zhu C Nature methods 40128288 Nat Methods 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40128288
A fluorogenic complementation tool kit for interrogating lipid droplet-organelle interaction. Li X, Gamuyao R, Wu ML, Cho WJ, King SV, Petersen RA, Stabley DR, Lindow C, Climer LK, Shirinifard A, Ferrara F, Throm RE, Robinson CG, Zhou Y, Carisey AF, Tebo AG, Chang CL The Journal of cell biology 38949658 J Cell Biol 2024 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/38949658
A fluorogenic complementation tool kit for interrogating lipid droplet-organelle interaction. Li X, Gamuyao R, Wu ML, Cho WJ, Kurtz NB, King SV, Petersen RA, Stabley DR, Lindow C, Climer L, Shirinifard A, Ferrara F, Throm RE, Robinson CG, Carisey A, Tebo AG, Chang CL bioRxiv : the preprint server for biology 38076863 bioRxiv 2023 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/38076863
Small LEA proteins mitigate air-water interface damage to fragile cryo-EM samples during plunge freezing. Abe KM, Li G, He Q, Grant T, Lim CJ Nature communications 39231985 Nat Commun 2024 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/39231985
Models for human telomere C-strand fill-in by CST-Polα-primase. He Q, Lim CJ Trends in biochemical sciences 37586999 Trends Biochem Sci 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37586999
Small LEA proteins as an effective air-water interface protectant for fragile samples during cryo-EM grid plunge freezing. Abe KM, Lim CJ bioRxiv : the preprint server for biology 38370693 bioRxiv 2024 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/38370693
LiveLattice: Real-time visualisation of tilted light-sheet microscopy data using a memory-efficient transformation algorithm. Wang Z, Hakozaki H, McMahon G, Medina-Carbonero M, Schöneberg J Journal of microscopy 39360400 J Microsc 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39360400
MitoTNT: Mitochondrial Temporal Network Tracking for 4D live-cell fluorescence microscopy data. Wang Z, Natekar P, Tea C, Tamir S, Hakozaki H, Schöneberg J PLoS computational biology 37083820 PLoS Comput Biol 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/37083820
LiveLattice: Real-time visualization of tilted light-sheet microscopy data using a memory-efficient transformation algorithm. Wang Z, Hakozaki H, McMahon G, Medina-Carbonero M, Schöneberg J bioRxiv : the preprint server for biology 38854017 bioRxiv 2024 May 30 https://www.ncbi.nlm.nih.gov/pubmed/38854017
A nucleosome switch primes Hepatitis B Virus infection. Prescott NA, Mansisidor A, Bram Y, Biaco T, Rendleman J, Faulkner SC, Lemmon AA, Lim C, Hamard PJ, Koche RP, Risca VI, Schwartz RE, David Y bioRxiv : the preprint server for biology 38915612 bioRxiv 2024 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/38915612
Chromatin accessibility: methods, mechanisms, and biological insights. Mansisidor AR, Risca VI Nucleus (Austin, Tex.) 36404679 Nucleus 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36404679
Determining mesoscale chromatin structure parameters from spatially correlated cleavage data using a coarse-grained oligonucleosome model. Clerkin AB, Pagane N, West DW, Spakowitz AJ, Risca VI bioRxiv : the preprint server for biology 39131347 bioRxiv 2024 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/39131347
Technological advances in probing 4D genome organization. Soroczynski J, Risca VI Current opinion in cell biology 37556867 Curr Opin Cell Biol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37556867
OpenTn5: Open-Source Resource for Robust and Scalable Tn5 Transposase Purification and Characterization. Soroczynski J, Anderson LJ, Yeung JL, Rendleman JM, Oren DA, Konishi HA, Risca VI bioRxiv : the preprint server for biology 39026714 bioRxiv 2024 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/39026714
Rapid structural analysis of bacterial ribosomes in situ. Powell BM, Brant TS, Davis JH, Mosalaganti S bioRxiv : the preprint server for biology 38585831 bioRxiv 2024 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/38585831
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III. Chen B, Stark DC, Jadhav PV, Lynn-Nguyen TM, Halligan BS, Rossiter NJ, Sindoni N, Shin M, Paulo JA, Chang M, Koo I, Koshkin S, Eyunni S, Ronchi P, Paulsen MT, Morlacchi P, Hanna DA, Lin J, Guerra RM, Pagliarini DJ, Banerjee R, Parolia A, Ljungman ME, Patterson AD, Mancias JD, Mosalaganti S, Sexton JZ, Calì T, Lyssiotis CA, Shah YM bioRxiv : the preprint server for biology 38352460 bioRxiv 2024 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/38352460
Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain. Navratna V, Kumar A, Rana JK, Mosalaganti S Life science alliance 38925866 Life Sci Alliance 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38925866
Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT). Navratna V, Kumar A, Rana JK, Mosalaganti S eLife 39196614 Elife 2024 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/39196614
Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation. Arya SB, Collie SP, Xu Y, Fernandez M, Sexton JZ, Mosalaganti S, Coulombe PA, Parent CA Nature cell biology 40404894 Nat Cell Biol 2025 Jun https://www.ncbi.nlm.nih.gov/pubmed/40404894
Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT). Navratna V, Kumar A, Rana JK, Mosalaganti S bioRxiv : the preprint server for biology 37961489 bioRxiv 2024 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/37961489
Rapid structural analysis of bacterial ribosomes in situ. Powell BM, Brant TS, Davis JH, Mosalaganti S Communications biology 39875527 Commun Biol 2025 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/39875527
Molecular Visualization of Neuronal TDP43 Pathology In Situ. Erwin AL, Chang ML, Fernandez MG, Attili D, Russ JE, Sutanto R, Pinarbasi ES, Bekier M, Brant TS, Hahn T, Dykstra M, Thomas D, Li X, Baldridge RD, Tank EMH, Barmada SJ, Mosalaganti S bioRxiv : the preprint server for biology 39229019 bioRxiv 2024 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/39229019
Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain. Navratna V, Kumar A, Rana JK, Mosalaganti S bioRxiv : the preprint server for biology 38187772 bioRxiv 2024 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/38187772
Towards sustainable and humane dairy farming: A low-cost electrochemical sensor for on-site diagnosis of milk fever. Soleimani A, Amirghasemi F, Al-Shami A, Khazaee Nejad S, Tsung A, Wang Y, Lara Galindo S, Parvin D, Olson A, Avishai A, Mousavi MPS Biosensors & bioelectronics 38749287 Biosens Bioelectron 2024 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/38749287
Toward Personalized Treatment of Depression: An Affordable Citalopram Test based on a Solid-Contact Potentiometric Electrode for at-Home Monitoring of the Antidepressant Dosage. Chen R, Amirghasemi F, Ma H, Ong V, Tran A, Mousavi MPS ACS sensors 37734027 ACS Sens 2023 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/37734027
SPOOC (Sensor for Periodic Observation of Choline): An Integrated Lab-on-a-Spoon Platform for At-Home Quantification of Choline in Infant Formula. Al-Shami A, Amirghasemi F, Soleimani A, Khazaee Nejad S, Ong V, Berkmen A, Ainla A, Mousavi MPS Small (Weinheim an der Bergstrasse, Germany) 38587168 Small 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38587168
Flexible Acetylcholine Neural Probe with a Hydrophobic Laser-Induced Graphene Electrode and a Fluorous-Phase Sensing Membrane. Amirghasemi F, Al-Shami A, Ushijima K, Mousavi MPS ACS materials letters 39309214 ACS Mater Lett 2024 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/39309214
Sustainable Agriculture with LEAFS: a Low-cost Electrochemical Analyzer of Foliage Stress. Nejad SK, Ma H, Al-Shami A, Soleimani A, Mohamed MA, Dankwah P, Lee HJ, Mousavi MPS Sensors & diagnostics 40352404 Sens Diagn 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/40352404
Lab-on-a-lollipop (LoL) platform for preventing food-induced toxicity: all-in-one system for saliva sampling and electrochemical detection of vanillin. Ma H, Khazaee Nejad S, Vargas Ramos D, Al-Shami A, Soleimani A, Amirghasemi F, Mohamed MA, Mousavi MPS Lab on a chip 39207360 Lab Chip 2024 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/39207360
LiFT (a Lithium Fiber-Based Test): An At-Home Companion Diagnostics for a Safer Lithium Therapy in Bipolar Disorder. Amirghasemi F, Nejad SK, Chen R, Soleimani A, Ong V, Shroff N, Eftekhari T, Ushijima K, Ainla A, Siegel S, Mousavi MPS Advanced healthcare materials 38563494 Adv Healthc Mater 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38563494
Coaching ribosome biogenesis from the nuclear periphery. Zhuang Y, Guo X, Razorenova OV, Miles CE, Zhao W, Shi X bioRxiv : the preprint server for biology 38948754 bioRxiv 2024 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/38948754
RBBP6 anchors pre-mRNA 3' end processing to nuclear speckles for efficient gene expression. Yoon Y, Bournique E, Soles LV, Yin H, Chu HF, Yin C, Zhuang Y, Liu X, Liu L, Jeong J, Yu C, Valdez M, Tian L, Huang L, Shi X, Seelig G, Ding F, Tong L, Buisson R, Shi Y Molecular cell 39798570 Mol Cell 2025 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/39798570
Expansion microscopy: A chemical approach for super-resolution microscopy. Zhuang Y, Shi X Current opinion in structural biology 37253290 Curr Opin Struct Biol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37253290
Label-Retention Expansion Microscopy (LR-ExM) for Enhanced Fluorescent Signals using Trifunctional Probes. Zhuang Y, Shi X Current protocols 38265180 Curr Protoc 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38265180
Proximity labeling expansion microscopy (PL-ExM) evaluates interactome labeling techniques. Park S, Wang X, Mo Y, Zhang S, Li X, Fong KC, Yu C, Tran AA, Scipioni L, Dai Z, Huang X, Huang L, Shi X Journal of materials chemistry. B 39105364 J Mater Chem B 2024 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/39105364
Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome. Park S, Wang X, Li X, Huang X, Fong KC, Yu C, Tran AA, Scipioni L, Dai Z, Huang L, Shi X bioRxiv : the preprint server for biology 38014020 bioRxiv 2023 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/38014020
Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis. Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J, Beier KT Research square 38045269 Res Sq 2023 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/38045269
Enhanced dynamic coupling in a nuclear receptor underlies ligand activity. Yu T, Villalona P, Khan SH, Mikeasky N, Meinert E, Magafas J, Pulahinge T, Bader A, Okafor CD The Journal of biological chemistry 39675705 J Biol Chem 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39675705
Phase Separation in Biology and Disease; Current Perspectives and Open Questions. Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea DM, Mueller-Cajar O, Portz B, Reilly JF, Reinkemeier CD, Sabari BR, Sanulli S, Shorter J, Sontag E, Strader L, Stachowiak J, Weber SC, White M, Zhang H, Zweckstetter M, Elbaum-Garfinkle S, Kriwacki R Journal of molecular biology 36690068 J Mol Biol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36690068
Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection. Abdullah L, Emiliani FE, Vaidya CM, Stuart H, Kolling FW, Ackerman ME, Song L, McKenna A, Huang YH bioRxiv : the preprint server for biology 38585810 bioRxiv 2024 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/38585810
The endogenous antigen-specific CD8(+) T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments. Abdullah L, Emiliani FE, Vaidya CM, Stuart H, Musial SC, Kolling FW, Obar JJ, Rosato PC, Ackerman ME, Song L, McKenna A, Huang YH Immunity 40020673 Immunity 2025 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/40020673
Genetically-Encoded Phase Separation Sensors Enable High-Fidelity Live-Cell Probing of Biomolecular Condensates. Avecilla ARC, Thomas J, Quiroz FG ACS sensors 39987501 ACS Sens 2025 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/39987501
Genetically-encoded phase separation sensors for intracellular probing of biomolecular condensates. Regina Chua Avecilla A, Thomas J, Quiroz FG bioRxiv : the preprint server for biology 39257779 bioRxiv 2024 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/39257779
Programmability and biomedical utility of intrinsically-disordered protein polymers. Giraldo-Castaño MC, Littlejohn KA, Avecilla ARC, Barrera-Villamizar N, Quiroz FG Advanced drug delivery reviews 39094909 Adv Drug Deliv Rev 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39094909
Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning. Laubscher E, Wang X, Razin N, Dougherty T, Xu RJ, Ombelets L, Pao E, Graf W, Moffitt JR, Yue Y, Van Valen D Cell systems 38754367 Cell Syst 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/38754367
CellSAM: A Foundation Model for Cell Segmentation. Israel U, Marks M, Dilip R, Li Q, Yu C, Laubscher E, Iqbal A, Pradhan E, Ates A, Abt M, Brown C, Pao E, Li S, Pearson-Goulart A, Perona P, Gkioxari G, Barnowski R, Yue Y, Van Valen D bioRxiv : the preprint server for biology 38045277 bioRxiv 2025 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/38045277
Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning. Laubscher E, Wang XJ, Razin N, Dougherty T, Xu RJ, Ombelets L, Pao E, Graf W, Moffitt JR, Yue Y, Van Valen D bioRxiv : the preprint server for biology 37732188 bioRxiv 2024 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/37732188
Generalized cell phenotyping for spatial proteomics with language-informed vision models. Wang XJ, Dilip R, Bussi Y, Brown C, Pradhan E, Jain Y, Yu K, Li S, Abt M, Börner K, Keren L, Yue Y, Barnowski R, Van Valen D bioRxiv : the preprint server for biology 39605651 bioRxiv 2024 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/39605651
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Rapid and Quantitative Functional Interrogation of Human Enhancer Variant Activity in Live Mice. Hollingsworth EW, Liu TA, Jacinto SH, Chen CX, Alcantara JA, Kvon EZ bioRxiv : the preprint server for biology 38105996 bioRxiv 2023 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/38105996
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The yeast ALA synthase C-terminus positively controls enzyme structure and function. Tran JU, Brown BL Protein science : a publication of the Protein Society 36807942 Protein Sci 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36807942
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Elucidating the Role of Human ALAS2 C-terminal Mutations Resulting in Loss of Function and Disease. Taylor JL, Ayres-Galhardo PH, Brown BL Biochemistry 38888931 Biochemistry 2024 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/38888931
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Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Markert JW, Vos SM, Farnung L Nature communications 38065958 Nat Commun 2023 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/38065958
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Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome. Yan T, Julio AR, Villanueva M, Jones AE, Ball AB, Boatner LM, Turmon AC, Nguyễn KB, Yen SL, Desai HS, Divakaruni AS, Backus KM Cell chemical biology 37419112 Cell Chem Biol 2023 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/37419112
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Functionalizing tandem mass tags for streamlining click-based quantitative chemoproteomics. Burton NR, Backus KM Communications chemistry 38600184 Commun Chem 2024 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/38600184
Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease. Zeng H, Huang J, Zhou H, Meilandt WJ, Dejanovic B, Zhou Y, Bohlen CJ, Lee SH, Ren J, Liu A, Tang Z, Sheng H, Liu J, Sheng M, Wang X Nature neuroscience 36732642 Nat Neurosci 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36732642
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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA. Chen H, Liu D, Guo J, Aditham A, Zhou Y, Tian J, Luo S, Ren J, Hsu A, Huang J, Kostas F, Wu M, Liu DR, Wang X Nature biotechnology 38519719 Nat Biotechnol 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/38519719
Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape. Ren J, Zhou H, Zeng H, Wang CK, Huang J, Qiu X, Sui X, Li Q, Wu X, Lin Z, Lo JA, Maher K, He Y, Tang X, Lam J, Chen H, Li B, Fisher DE, Liu J, Wang X Nature methods 37038000 Nat Methods 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37038000
Spatial atlas of the mouse central nervous system at molecular resolution. Shi H, He Y, Zhou Y, Huang J, Maher K, Wang B, Tang Z, Luo S, Tan P, Wu M, Lin Z, Ren J, Thapa Y, Tang X, Chan KY, Deverman BE, Shen H, Liu A, Liu J, Wang X Nature 37758947 Nature 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37758947
Graph-based autoencoder integrates spatial transcriptomics with chromatin images and identifies joint biomarkers for Alzheimer's disease. Zhang X, Wang X, Shivashankar GV, Uhler C Nature communications 36463283 Nat Commun 2022 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/36463283
Diversity of ribosomes at the level of rRNA variation associated with human health and disease. Rothschild D, Susanto TT, Sui X, Spence JP, Rangan R, Genuth NR, Sinnott-Armstrong N, Wang X, Pritchard JK, Barna M bioRxiv : the preprint server for biology 36778251 bioRxiv 2024 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/36778251
Spatial omics advances for in situ RNA biology. Ren J, Luo S, Shi H, Wang X Molecular cell 39270643 Mol Cell 2024 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/39270643
Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation. Chen H, Liu D, Aditham A, Guo J, Huang J, Kostas F, Maher K, Friedrich MJ, Xavier RJ, Zhang F, Wang X Nature biotechnology 39313647 Nat Biotechnol 2024 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/39313647
Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks. Sui X, Lo JA, Luo S, He Y, Tang Z, Lin Z, Zhou Y, Wang WX, Liu J, Wang X bioRxiv : the preprint server for biology 39149316 bioRxiv 2024 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/39149316
Tracking the transition from an ATG9A vesicle to an autophagosome. Broadbent D, Barnaba C, Schmidt JC Autophagy 37405380 Autophagy 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/37405380
Systematic analysis of the molecular and biophysical properties of key DNA damage response factors. Heyza JR, Mikhova M, Bahl A, Broadbent DG, Schmidt JC eLife 37341699 Elife 2023 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/37341699
The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. Broadbent DG, McEwan CM, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL bioRxiv : the preprint server for biology 38077022 bioRxiv 2023 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/38077022
The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain. Heyza JR, Mikhova M, Perez GI, Broadbent DG, Schmidt JC bioRxiv : the preprint server for biology 39868091 bioRxiv 2025 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/39868091
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells. Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC Nature communications 39578493 Nat Commun 2024 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/39578493
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells. Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC bioRxiv : the preprint server for biology 38826211 bioRxiv 2024 May 25 https://www.ncbi.nlm.nih.gov/pubmed/38826211
AMPK regulates phagophore-to-autophagosome maturation. Barnaba C, Broadbent DG, Kaminsky EG, Perez GI, Schmidt JC The Journal of cell biology 38775785 J Cell Biol 2024 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/38775785
AMPK Regulates Phagophore-to-Autophagosome Maturation. Barnaba C, Broadbent DG, Perez GI, Schmidt JC bioRxiv : the preprint server for biology 37808644 bioRxiv 2023 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/37808644
RHINO restricts MMEJ activity to mitosis. Brambati A, Sacco O, Porcella S, Heyza J, Kareh M, Schmidt JC, Sfeir A bioRxiv : the preprint server for biology 36993461 bioRxiv 2023 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/36993461
Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation. Broadbent DG, Barnaba C, Perez GI, Schmidt JC The Journal of cell biology 37115157 J Cell Biol 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/37115157
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres. Janovič T, Perez GI, Schmidt JC bioRxiv : the preprint server for biology 39763972 bioRxiv 2024 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/39763972
Live cell single-molecule imaging to study DNA repair in human cells. Heyza JR, Mikhova M, Schmidt JC DNA repair 37467632 DNA Repair (Amst) 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37467632
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PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress. Mashayekhi F, Ganje C, Caron MC, Heyza JR, Gao Y, Zeinali E, Fanta M, Li L, Ali J, Mersaoui SY, Schmidt JC, Godbout R, Masson JY, Weinfeld M, Ismail IH Cell reports 39671289 Cell Rep 2024 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/39671289
Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates. Broadbent DG, McEwan CM, Jayatunge D, Kaminsky EG, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL Molecular biology of the cell 39718773 Mol Biol Cell 2025 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/39718773
Native SAD phasing at room temperature. Greisman JB, Dalton KM, Sheehan CJ, Klureza MA, Kurinov I, Hekstra DR Acta crystallographica. Section D, Structural biology 35916223 Acta Crystallogr D Struct Biol 2022 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/35916223
MatchMaps: Non-isomorphous difference maps for X-ray crystallography. Brookner DE, Hekstra DR bioRxiv : the preprint server for biology 37732267 bioRxiv 2024 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/37732267
Correcting systematic errors in diffraction data with modern scaling algorithms. Aldama LA, Dalton KM, Hekstra DR Acta crystallographica. Section D, Structural biology 37584427 Acta Crystallogr D Struct Biol 2023 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/37584427
Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme. Greisman JB, Dalton KM, Brookner DE, Klureza MA, Sheehan CJ, Kim IS, Henning RW, Russi S, Hekstra DR bioRxiv : the preprint server for biology 37398233 bioRxiv 2023 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/37398233
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AlphaFold as a Prior: Experimental Structure Determination Conditioned on a Pretrained Neural Network. Fadini A, Li M, McCoy AJ, Terwilliger TC, Read RJ, Hekstra D, AlQuraishi M bioRxiv : the preprint server for biology 40027838 bioRxiv 2025 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/40027838
Emerging Time-Resolved X-Ray Diffraction Approaches for Protein Dynamics. Hekstra DR Annual review of biophysics 37159292 Annu Rev Biophys 2023 May 9 https://www.ncbi.nlm.nih.gov/pubmed/37159292
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Scaling and merging time-resolved pink-beam diffraction with variational inference. Zielinski KA, Dolamore C, Wang HK, Henning RW, Wilson MA, Pollack L, Srajer V, Hekstra DR, Dalton KM Structural dynamics (Melville, N.Y.) 39629168 Struct Dyn 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39629168
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Mapping protein conformational landscapes from crystallographic drug fragment screens. Saeed AA, Klureza MA, Hekstra DR bioRxiv : the preprint server for biology 39131376 bioRxiv 2024 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/39131376
Sensitive Detection of Structural Differences using a Statistical Framework for Comparative Crystallography. Hekstra DR, Wang HK, Klureza MA, Greisman JB, Dalton KM bioRxiv : the preprint server for biology 39091831 bioRxiv 2024 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/39091831
Insights into VDAC Gating: Room-Temperature X-ray Crystal Structure of mVDAC-1. Gonzalez-DeWhitt KR, Ermolova N, Wang HK, Hekstra DR, Althoff T, Abramson J Biomolecules 39456136 Biomolecules 2024 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/39456136
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Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Greisman JB, Dalton KM, Brookner DE, Klureza MA, Sheehan CJ, Kim IS, Henning RW, Russi S, Hekstra DR Proceedings of the National Academy of Sciences of the United States of America 38386706 Proc Natl Acad Sci U S A 2024 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/38386706
A unifying Bayesian framework for merging X-ray diffraction data. Dalton KM, Greisman JB, Hekstra DR Nature communications 36522310 Nat Commun 2022 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/36522310
Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron. Zielinski KA, Dolamore C, Dalton KM, Smith N, Termini J, Henning R, Srajer V, Hekstra DR, Pollack L, Wilson MA bioRxiv : the preprint server for biology 39071394 bioRxiv 2024 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/39071394
Scaling and Merging Time-Resolved Laue Data with Variational Inference. Zielinski KA, Dolamore C, Wang HK, Henning RW, Wilson MA, Pollack L, Srajer V, Hekstra DR, Dalton KM bioRxiv : the preprint server for biology 39131362 bioRxiv 2024 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/39131362
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Genome-wide absolute quantification of chromatin looping. Jusuf JM, Grosse-Holz S, Gabriele M, Mach P, Flyamer IM, Zechner C, Giorgetti L, Mirny LA, Hansen AS bioRxiv : the preprint server for biology 39935886 bioRxiv 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39935886
A Protocol for Studying Transcription Factor Dynamics Using Fast Single-Particle Tracking and Spot-On Model-Based Analysis. Jha A, Hansen AS Methods in molecular biology (Clifton, N.J.) 35103967 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35103967
Tracking and interpreting long-range chromatin interactions with super-resolution live-cell imaging. Brandão HB, Gabriele M, Hansen AS Current opinion in cell biology 33310227 Curr Opin Cell Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33310227
Promoters adopt distinct dynamic manifestations depending on transcription factor context. Hansen AS, Zechner C Molecular systems biology 33595925 Mol Syst Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33595925
Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments. Goel VY, Huseyin MK, Hansen AS Nature genetics 37157000 Nat Genet 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37157000
Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. Cerda-Smith CG, Hutchinson HM, Liu A, Goel VY, Sept C, Kim H, Casaní-Galdón S, Burkman KG, Bassil CF, Hansen AS, Aryee MJ, Johnstone SE, Eyler CE, Wood KC bioRxiv : the preprint server for biology 37786671 bioRxiv 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37786671
Enhancer selectivity in space and time: from enhancer-promoter interactions to promoter activation. Yang JH, Hansen AS Nature reviews. Molecular cell biology 38413840 Nat Rev Mol Cell Biol 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38413840
Dynamics of microcompartment formation at the mitosis-to-G1 transition. Goel VY, Aboreden NG, Jusuf JM, Zhang H, Mori LP, Mirny LA, Blobel GA, Banigan EJ, Hansen AS bioRxiv : the preprint server for biology 39345388 bioRxiv 2024 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/39345388
Molecular models of bidirectional promoter regulation. Nemsick S, Hansen AS Current opinion in structural biology 38905929 Curr Opin Struct Biol 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38905929
Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging. Gabriele M, Brandão HB, Grosse-Holz S, Jha A, Dailey GM, Cattoglio C, Hsieh TS, Mirny L, Zechner C, Hansen AS Science (New York, N.Y.) 35420890 Science 2022 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/35420890
Reeling it in: how DNA topology drives loop extrusion by condensin. Narducci DN, Hansen AS Nature structural & molecular biology 35835869 Nat Struct Mol Biol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35835869
Enhancer-promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1. Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X, Tjian R Nature genetics 36471071 Nat Genet 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36471071
DNA double-strand break end synapsis by DNA loop extrusion. Yang JH, Brandão HB, Hansen AS Nature communications 37024496 Nat Commun 2023 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/37024496
Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging. Mahadevan J, Jha A, Rudolph J, Bowerman S, Narducci D, Hansen AS, Luger K iScience 36594010 iScience 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36594010
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells. Drayton JA, Hansen AS Molecular cell 36270244 Mol Cell 2022 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/36270244
Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation. Kim KL, Rahme GJ, Goel VY, El Farran CA, Hansen AS, Bernstein BE Molecular cell 38452764 Mol Cell 2024 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/38452764
LDB1 establishes multi-enhancer networks to regulate gene expression. Aboreden NG, Lam JC, Goel VY, Wang S, Wang X, Midla SC, Quijano A, Keller CA, Giardine BM, Hardison RC, Zhang H, Hansen AS, Blobel GA bioRxiv : the preprint server for biology 39229045 bioRxiv 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39229045
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Removal of Antibiotic Resistant Bacteria and Genes by UV-Assisted Electrochemical Oxidation on Degenerative TiO(2) Nanotube Arrays. Wang S, Yang S, Quispe E, Yang H, Sanfiorenzo C, Rogers SW, Wang K, Yang Y, Hoffmann MR ACS ES&T engineering 39605952 ACS ES T Eng 2021 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/39605952
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Structural and energetic analysis of stabilizing indel mutations. Gutierrez YM, Rocklin GJ bioRxiv : the preprint server for biology 39763793 bioRxiv 2024 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/39763793
Large-scale discovery, analysis, and design of protein energy landscapes. Ferrari ÁJR, Dixit SM, Thibeault J, Garcia M, Houliston S, Ludwig RW, Notin P, Phoumyvong CM, Martell CM, Jung MD, Tsuboyama K, Carter L, Arrowsmith CH, Guttman M, Rocklin GJ bioRxiv : the preprint server for biology 40196533 bioRxiv 2025 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/40196533
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Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state. Nodelman IM, Das S, Faustino AM, Fried SD, Bowman GD, Armache JP Nature structural & molecular biology 35173352 Nat Struct Mol Biol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35173352
Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional. Nissley DA, Jiang Y, Trovato F, Sitarik I, Narayan KB, To P, Xia Y, Fried SD, O'Brien EP Nature communications 35654797 Nat Commun 2022 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/35654797
Secretion-Catalyzed Assembly of Protein Biomaterials on a Bacterial Membrane Surface. Xie Q, On Lee S, Vissamsetti N, Guo S, Johnson ME, Fried SD Angewandte Chemie (International ed. in English) 37469298 Angew Chem Int Ed Engl 2023 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/37469298
Progress toward Proteome-Wide Photo-Cross-Linking to Enable Residue-Level Visualization of Protein Structures and Networks In Vivo. Faustino AM, Sharma P, Manriquez-Sandoval E, Yadav D, Fried SD Analytical chemistry 37341467 Anal Chem 2023 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/37341467
Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements. Lan PD, Nissley DA, Sitarik I, Vu QV, Jiang Y, To P, Xia Y, Fried SD, Li MS, O'Brien EP Journal of molecular biology 38341172 J Mol Biol 2024 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/38341172
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Cognition-Associated Protein Structural Changes in a Rat Model of Aging are Related to Reduced Refolding Capacity. Tarbox HE, Branch A, Fried SD bioRxiv : the preprint server for biology 39386726 bioRxiv 2024 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/39386726
Cryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms. Ashaduzzaman M, Taheri A, Lee YJ, Tang Y, Guo F, Fried SD, Liu B, Al-Bassam J bioRxiv : the preprint server for biology 40034650 bioRxiv 2025 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/40034650
Proteome-Wide Assessment of Protein Structural Perturbations Under High Pressure. Moran HM, Manriquez-Sandoval E, Sharma P, Fried SD, Gillilan RE PRX life 40491869 PRX Life 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/40491869
Nonrefoldability is Pervasive Across the E. coli Proteome. To P, Whitehead B, Tarbox HE, Fried SD Journal of the American Chemical Society 34308638 J Am Chem Soc 2021 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/34308638
FLiPPR: A Processor for Limited Proteolysis (LiP) Mass Spectrometry Data Sets Built on FragPipe. Manriquez-Sandoval E, Brewer J, Lule G, Lopez S, Fried SD Journal of proteome research 38787630 J Proteome Res 2024 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/38787630
Intracellular Formation of a DNA Damage-Induced, Histone Post-Translational Modification Following Bleomycin Treatment. Jacinto MP, Fried SD, Greenberg MM Journal of the American Chemical Society 35467863 J Am Chem Soc 2022 May 4 https://www.ncbi.nlm.nih.gov/pubmed/35467863
How synonymous mutations alter enzyme structure and function over long timescales. Jiang Y, Neti SS, Sitarik I, Pradhan P, To P, Xia Y, Fried SD, Booker SJ, O'Brien EP Nature chemistry 36471044 Nat Chem 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36471044
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Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome. Metzner E, Southard KM, Norman TM Cell systems 39689711 Cell Syst 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39689711
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Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS Cell 35688146 Cell 2022 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/35688146
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states. Southard KM, Ardy RC, Tang A, O'Sullivan DD, Metzner E, Guruvayurappan K, Norman TM bioRxiv : the preprint server for biology 39131349 bioRxiv 2024 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/39131349
Revealing the hidden reality of the mammalian 12-h ultradian rhythms. Ballance H, Zhu B Cellular and molecular life sciences : CMLS 33449146 Cell Mol Life Sci 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33449146
Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle. Zhu B Physiology (Bethesda, Md.) 35658626 Physiology (Bethesda) 2022 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/35658626
Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis. Dion W, Ballance H, Lee J, Pan Y, Irfan S, Edwards C, Sun M, Zhang J, Zhang X, Liu S, Zhu B Science advances 34985945 Sci Adv 2022 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/34985945
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies. Dion W, Tao Y, Chambers M, Zhao S, Arbuckle RK, Sun M, Kubra S, Schaich MA, Nie Y, Ye M, Jamal I, Larsen MB, Camarco D, Ickes E, Wang HH, DuPont C, Wang B, Liu S, Pi S, Van Houten B, Chen BB, Chen Y, Chen X, Zhu B bioRxiv : the preprint server for biology 38659924 bioRxiv 2025 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/38659924
Preservation of ∼12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Zhu B, Liu S bioRxiv : the preprint server for biology 37205336 bioRxiv 2023 May 2 https://www.ncbi.nlm.nih.gov/pubmed/37205336
XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Meng H, Gonzales NM, Lonard DM, Putluri N, Zhu B, Dacso CC, York B, O'Malley BW Nature communications 33277471 Nat Commun 2020 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/33277471
Temporal gene expression patterns in the coral Euphyllia paradivisa reveal the complexity of biological clocks in the cnidarian-algal symbiosis. Rinsky M, Weizman E, Ben-Asher HW, Eyal G, Zhu B, Levy O Science advances 36112690 Sci Adv 2022 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/36112690
Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions. Asher G, Zhu B Hepatology (Baltimore, Md.) 35591797 Hepatology 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/35591797
LEF1 isoforms regulate cellular senescence and aging. Jia M, Sayed K, Kapetanaki MG, Dion W, Rosas L, Irfan S, Valenzi E, Mora AL, Lafyatis RA, Rojas M, Zhu B, Benos PV bioRxiv : the preprint server for biology 37502913 bioRxiv 2023 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/37502913
The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis. Kubra S, Sun M, Dion W, Catak A, Luong H, Wang H, Pan Y, Liu JJ, Ponna A, Liu L, Sipula I, Luo JH, Jurczak MJ, Liu S, Zhu B bioRxiv : the preprint server for biology 39314427 bioRxiv 2025 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/39314427
Evidence for ~12-h ultradian gene programs in humans. Zhu B, Liu S, David NL, Dion W, Doshi NK, Siegel LB, Amorim T, Andrews RE, Kumar GVN, Li H, Irfan S, Pesaresi T, Sharma AX, Sun M, Fazeli PK, Steinhauser ML Npj biological timing and sleep 39148626 NPJ Biol Timing Sleep 2024 https://www.ncbi.nlm.nih.gov/pubmed/39148626
Decoding the function and regulation of the mammalian 12-h clock. Zhu B Journal of molecular cell biology 32384155 J Mol Cell Biol 2020 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/32384155
Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Meng H, Gonzales NM, Jung SY, Lu Y, Putluri N, Zhu B, Dacso CC, Lonard DM, O'Malley BW Cell reports 35263593 Cell Rep 2022 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/35263593
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Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia. Scott MR, Zong W, Ketchesin KD, Seney ML, Tseng GC, Zhu B, McClung CA PLoS biology 36693045 PLoS Biol 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36693045
Evidence for conservation of primordial ~12-hour ultradian gene programs in humans under free-living conditions. Zhu B, Liu S, David NL, Dion W, Doshi NK, Siegel LB, Amorim T, Andrews RE, Naveen Kumar GV, Li H, Irfan S, Pesaresi T, Sharma AX, Sun M, Fazeli PK, Steinhauser ML bioRxiv : the preprint server for biology 37205600 bioRxiv 2023 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/37205600
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Engaging endogenous opioid circuits in pain affective processes. Kimmey BA, McCall NM, Wooldridge LM, Satterthwaite TD, Corder G Journal of neuroscience research 33314372 J Neurosci Res 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/33314372
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Engineered serum markers for non-invasive monitoring of gene expression in the brain. Lee S, Nouraein S, Kwon JJ, Huang Z, Wojick JA, Xia B, Corder G, Szablowski JO Nature biotechnology 38200117 Nat Biotechnol 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/38200117
Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles. Rogers SA, Heller EA, Corder G bioRxiv : the preprint server for biology 38352491 bioRxiv 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/38352491
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Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types. Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G Nature communications 37704594 Nat Commun 2023 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/37704594
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Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma. Kwok HS, Freedy AM, Siegenfeld AP, Morriss JW, Waterbury AL, Kissler SM, Liau BB Nature chemical biology 36973442 Nat Chem Biol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/36973442
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Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Waterbury AL, Caroli J, Zhang O, Tuttle PR, Liu C, Li J, Park JS, Hoenig SM, Barone M, Furui A, Mattevi A, Liau BB Nature communications 40175327 Nat Commun 2025 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/40175327
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Base Editor Scanning Reveals Activating Mutations of DNMT3A. Garcia EM, Lue NZ, Liang JK, Lieberman WK, Hwang DD, Woods JC, Liau BB ACS chemical biology 37603861 ACS Chem Biol 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37603861
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Discovering new biology with drug-resistance alleles. Freedy AM, Liau BB Nature chemical biology 34799733 Nat Chem Biol 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34799733
CRISPR-Suppressor Scanning for Systematic Discovery of Drug-Resistance Mutations. Ngan KC, Lue NZ, Lee C, Liau BB Current protocols 36541895 Curr Protoc 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36541895
CRISPR tiling screen reveals cancer epigenetic 'Goldilocks' state. Barka A, Kohli RM, Shi J Trends in pharmacological sciences 37328396 Trends Pharmacol Sci 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37328396
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Aldehyde Production in Crude Lysate- and Whole Cell-Based Biotransformation Using a Noncanonical Redox Cofactor System. Richardson KN, Black WB, Li H ACS catalysis 34306803 ACS Catal 2020 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/34306803
Growth-Based, High-Throughput Selection for NADH Preference in an Oxygen-Dependent Biocatalyst. Maxel S, Saleh S, King E, Aspacio D, Zhang L, Luo R, Li H ACS synthetic biology 34469126 ACS Synth Biol 2021 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/34469126
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Leveraging Oxidative Stress to Regulate Redox Balance-Based, In Vivo Growth Selections for Oxygenase Engineering. Maxel S, King E, Zhang Y, Luo R, Li H ACS synthetic biology 32966747 ACS Synth Biol 2020 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/32966747
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A Growth-Based, High-Throughput Selection Platform Enables Remodeling of 4-Hydroxybenzoate Hydroxylase Active Site. Maxel S, Aspacio D, King E, Zhang L, Acosta AP, Li H ACS catalysis 34295569 ACS Catal 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/34295569
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Developmental transcriptomes predict adult social behaviors in the socially flexible sweat bee, Lasioglossum baleicum. Omufwoko KS, Cronin AL, Nguyen TTH, Webb AE, Traniello IM, Kocher SD bioRxiv : the preprint server for biology 37645955 bioRxiv 2023 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/37645955
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The mechanism of RNA capping by SARS-CoV-2. Park GJ, Osinski A, Hernandez G, Eitson JL, Majumdar A, Tonelli M, Henzler-Wildman K, Pawłowski K, Chen Z, Li Y, Schoggins JW, Tagliabracci VS Research square 35194601 Res Sq 2022 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/35194601
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A Legionella effector kinase is activated by host inositol hexakisphosphate. Sreelatha A, Nolan C, Park BC, Pawłowski K, Tomchick DR, Tagliabracci VS The Journal of biological chemistry 32229585 J Biol Chem 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32229585
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Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening. Khan SA, Park KM, Fischer LA, Dong C, Lungjangwa T, Jimenez M, Casalena D, Chew B, Dietmann S, Auld DS, Jaenisch R, Theunissen TW Cell reports 34133938 Cell Rep 2021 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/34133938
Derivation of trophoblast stem cells from naïve human pluripotent stem cells. Dong C, Beltcheva M, Gontarz P, Zhang B, Popli P, Fischer LA, Khan SA, Park KM, Yoon EJ, Xing X, Kommagani R, Wang T, Solnica-Krezel L, Theunissen TW eLife 32048992 Elife 2020 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/32048992
Modeling X-chromosome inactivation and reactivation during human development. Khan SA, Theunissen TW Current opinion in genetics & development 37597506 Curr Opin Genet Dev 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37597506
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Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution. Fischer LA, Meyer B, Reyes M, Zemke JE, Harrison JK, Park KM, Wang T, Jüppner H, Dietmann S, Theunissen TW Stem cell reports 39952244 Stem Cell Reports 2025 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/39952244
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens. Karvas RM, Khan SA, Verma S, Yin Y, Kulkarni D, Dong C, Park KM, Chew B, Sane E, Fischer LA, Kumar D, Ma L, Boon ACM, Dietmann S, Mysorekar IU, Theunissen TW Cell stem cell 35523141 Cell Stem Cell 2022 May 5 https://www.ncbi.nlm.nih.gov/pubmed/35523141
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OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Huang X, Park KM, Gontarz P, Zhang B, Pan J, McKenzie Z, Fischer LA, Dong C, Dietmann S, Xing X, Shliaha PV, Yang J, Li D, Ding J, Lungjangwa T, Mitalipova M, Khan SA, Imsoonthornruksa S, Jensen N, Wang T, Kadoch C, Jaenisch R, Wang J, Theunissen TW Nature communications 34446700 Nat Commun 2021 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/34446700
iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation. Morey R, Bui T, Cheung VC, Dong C, Zemke JE, Requena D, Arora H, Jackson MG, Pizzo D, Theunissen TW, Horii M iScience 38623329 iScience 2024 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/38623329
SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids. Kumar D, Karvas RM, Jones BR, McColl ER, Diveley E, Sukanta J, Surendra S, Kelly JC, Theunissen TW, Mysorekar IU bioRxiv : the preprint server for biology 39386577 bioRxiv 2024 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/39386577
A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Dong C, Fu S, Karvas RM, Chew B, Fischer LA, Xing X, Harrison JK, Popli P, Kommagani R, Wang T, Zhang B, Theunissen TW Nature communications 35538076 Nat Commun 2022 May 10 https://www.ncbi.nlm.nih.gov/pubmed/35538076
Accessing the human trophoblast stem cell state from pluripotent and somatic cells. Karvas RM, David L, Theunissen TW Cellular and molecular life sciences : CMLS 36434136 Cell Mol Life Sci 2022 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/36434136
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Biomaterials to enhance stem cell transplantation. Kharbikar BN, Mohindra P, Desai TA Cell stem cell 35483364 Cell Stem Cell 2022 May 5 https://www.ncbi.nlm.nih.gov/pubmed/35483364
Modular control of l-tryptophan isotopic substitution via an efficient biosynthetic cascade. Thompson CM, McDonald AD, Yang H, Cavagnero S, Buller AR Organic & biomolecular chemistry 32452506 Org Biomol Chem 2020 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/32452506
Engineered Biocatalytic Synthesis of β-N-Substituted-α-Amino Acids. Villalona J, Higgins PM, Buller AR Angewandte Chemie (International ed. in English) 37625129 Angew Chem Int Ed Engl 2023 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/37625129
Biocatalytic asymmetric aldol addition into unactivated ketones. Bruffy SK, Meza A, Soler J, Doyon TJ, Young SH, Lim J, Huseth KG, Willoughby PH, Garcia-Borràs M, Buller AR Nature chemistry 39333392 Nat Chem 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39333392
Occupational modulation in the (3+1)-dimensional incommensurate structure of (2S,3S)-2-amino-3-hydroxy-3-methyl-4-phenoxybutanoic acid dihydrate. Sanders KM, Bruffy SK, Buller AR, Petříček V, Guzei IA Acta crystallographica. Section C, Structural chemistry 39115533 Acta Crystallogr C Struct Chem 2024 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/39115533
Promiscuity Guided Evolution of Decarboxylative Aldolases for Synthesis of Tertiary γ-Hydroxy Amino Acids. Campbell ME, Ohler AR, McGill MJ, Buller AR Angewandte Chemie (International ed. in English) 39874202 Angew Chem Int Ed Engl 2025 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/39874202
Investigation of β-Substitution Activity of O-Acetylserine Sulfhydrolase from Citrullus vulgaris. Smith JL, Harrison IM, Bingman CA, Buller AR Chembiochem : a European journal of chemical biology 35476889 Chembiochem 2022 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/35476889
Efficient chemoenzymatic synthesis of α-aryl aldehydes as intermediates in C-C bond forming biocatalytic cascades. Meza A, Campbell ME, Zmich A, Thein SA, Grieger AM, McGill MJ, Willoughby PH, Buller AR ACS catalysis 36420479 ACS Catal 2022 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/36420479
Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB. Watkins-Dulaney EJ, Dunham NP, Straathof S, Turi S, Arnold FH, Buller AR Angewandte Chemie (International ed. in English) 34269506 Angew Chem Int Ed Engl 2021 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/34269506
Site-Selective Deuteration of Amino Acids through Dual-Protein Catalysis. Doyon TJ, Buller AR Journal of the American Chemical Society 35416652 J Am Chem Soc 2022 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/35416652
Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis. McDonald AD, Higgins PM, Buller AR Nature communications 36068220 Nat Commun 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/36068220
Engineering Enzyme Substrate Scope Complementarity for Promiscuous Cascade Synthesis of 1,2-Amino Alcohols. McDonald AD, Bruffy SK, Kasat AT, Buller AR Angewandte Chemie (International ed. in English) 36136093 Angew Chem Int Ed Engl 2022 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/36136093
Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction. Ellis JM, Campbell ME, Kumar P, Geunes EP, Bingman CA, Buller AR Nature catalysis 35935533 Nat Catal 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35935533
Substrate-Multiplexed Assessment of Aromatic Prenyltransferase Activity. Higgins PM, Wehrli NG, Buller AR Chembiochem : a European journal of chemical biology 39317170 Chembiochem 2025 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/39317170
Elucidation of the stereochemical mechanism of cystathionine γ-lyase reveals how substrate specificity constrains catalysis. Zmich A, Perkins LJ, Bingman C, Buller AR ACS catalysis 39391268 ACS Catal 2024 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/39391268
Scalable and Selective β-Hydroxy-α-Amino Acid Synthesis Catalyzed by Promiscuous l-Threonine Transaldolase ObiH. Doyon TJ, Kumar P, Thein S, Kim M, Stitgen A, Grieger AM, Madigan C, Willoughby PH, Buller AR Chembiochem : a European journal of chemical biology 34699683 Chembiochem 2022 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/34699683
l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate. Kumar P, Meza A, Ellis JM, Carlson GA, Bingman CA, Buller AR ACS chemical biology 33337128 ACS Chem Biol 2021 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/33337128
Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family. Zmich A, Perkins LJ, Bingman C, Acheson JF, Buller AR ACS catalysis 37720819 ACS Catal 2023 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/37720819
CRISPR screen for rAAV production implicates genes associated with infection. O'Driscoll EE, Arora S, Lang JF, Davidson BL, Shalem O bioRxiv : the preprint server for biology 39345423 bioRxiv 2024 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/39345423
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CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB-specific degradation. Cajka G, Liu M, Shalem O bioRxiv : the preprint server for biology 39464063 bioRxiv 2024 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/39464063
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Efficient and flexible tagging of endogenous genes by homology-independent intron targeting. Serebrenik YV, Sansbury SE, Kumar SS, Henao-Mejia J, Shalem O Genome research 31239279 Genome Res 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31239279
Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics. Serebrenik YV, Mani D, Maujean T, Burslem GM, Shalem O Research square 37790450 Res Sq 2023 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/37790450
Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, Fan W, Moaddeli D, Tsui CK, Castro Torres T, Alcala A, Moehle EA, Hoang S, Shalem O, Adams PD, Thorwald MA, Higuchi-Sanabria R Aging cell 36404134 Aging Cell 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36404134
High-throughput optimized prime editing mediated endogenous protein tagging for pooled imaging of protein localization. Sanchez HM, Lapidot T, Shalem O bioRxiv : the preprint server for biology 39345511 bioRxiv 2024 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/39345511
Intracellular Protein Editing to Enable Incorporation of Non-Canonical Residues into Endogenous Proteins. Beyer JN, Serebrenik YV, Toy K, Najar MA, Raniszewski NR, Shalem O, Burslem GM bioRxiv : the preprint server for biology 39026884 bioRxiv 2024 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/39026884
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Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins. Viera Ortiz AP, Cajka G, Olatunji OA, Mikytuck B, Shalem O, Lee EB Brain : a journal of neurology 36516294 Brain 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/36516294
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. Sweeney KM, Chantarawong S, Barbieri EM, Cajka G, Liu M, Spruce L, Fazelinia H, Portz B, Copley K, Lapidot T, Duhamel L, Greenwald P, Saida N, Shalgi R, Shorter J, Shalem O PLoS genetics 38315730 PLoS Genet 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38315730
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Detecting and Rescuing Stalled Ribosomes. Yip MCJ, Shao S Trends in biochemical sciences 33966939 Trends Biochem Sci 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33966939
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Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. Koga Y, Hoang EM, Park Y, Keszei AFA, Murray J, Shao S, Liau BB Journal of the American Chemical Society 34403584 J Am Chem Soc 2021 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/34403584
The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization. McKenna MJ, Shao S Cold Spring Harbor perspectives in biology 36041782 Cold Spring Harb Perspect Biol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36041782
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Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery. Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Rajaei M, Townsend JP, Muzumdar MD, Wang S bioRxiv : the preprint server for biology 37546882 bioRxiv 2024 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/37546882
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Li Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox AL, Britto CJ, Yuan S, Wang S, Sun Z Proceedings of the National Academy of Sciences of the United States of America 39541357 Proc Natl Acad Sci U S A 2024 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/39541357
New mechanism of chromatin compartmentalization by BRD2. Cheng Y, Wang S Trends in genetics : TIG 35811175 Trends Genet 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/35811175
TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations. Cheng Y, Liu M, Hu M, Wang S Genome biology 34749781 Genome Biol 2021 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/34749781
Chromatin tracing and multiplexed imaging of nucleome architectures (MINA) and RNAs in single mammalian cells and tissue. Liu M, Yang B, Hu M, Radda JSD, Chen Y, Jin S, Cheng Y, Wang S Nature protocols 33903756 Nat Protoc 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33903756
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Chromatin Tracing: Imaging 3D Genome and Nucleome. Hu M, Wang S Trends in cell biology 33191055 Trends Cell Biol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33191055
Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos. Sawh AN, Shafer MER, Su JH, Zhuang X, Wang S, Mango SE Molecular cell 32105612 Mol Cell 2020 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/32105612
Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue. Cheng Y, Dang S, Zhang Y, Chen Y, Yu R, Liu M, Jin S, Han A, Katz S, Wang S bioRxiv : the preprint server for biology 40161724 bioRxiv 2025 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/40161724
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G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration. Boraas LC, Hu M, Martino P, Thornton L, Vejnar CE, Zhen G, Zeng L, Parker DM, Cox AL, Giraldez AJ, Su X, Mayr C, Wang S, Nicoli S Cell reports 39883578 Cell Rep 2025 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/39883578
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden. Caraballo-Rodríguez AM, Puckett SP, Kyle KE, Petras D, da Silva R, Nothias LF, Ernst M, van der Hooft JJJ, Tripathi A, Wang M, Balunas MJ, Klassen JL, Dorrestein PC mSystems 34342533 mSystems 2021 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/34342533
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. Behsaz B, Bode E, Gurevich A, Shi YN, Grundmann F, Acharya D, Caraballo-Rodríguez AM, Bouslimani A, Panitchpakdi M, Linck A, Guan C, Oh J, Dorrestein PC, Bode HB, Pevzner PA, Mohimani H Nature communications 34050176 Nat Commun 2021 May 28 https://www.ncbi.nlm.nih.gov/pubmed/34050176
A Metabolome- and Metagenome-Wide Association Network Reveals Microbial Natural Products and Microbial Biotransformation Products from the Human Microbiota. Cao L, Shcherbin E, Mohimani H mSystems 31455639 mSystems 2019 Aug 27 https://www.ncbi.nlm.nih.gov/pubmed/31455639
De Novo Peptide Sequencing Reveals Many Cyclopeptides in the Human Gut and Other Environments. Behsaz B, Mohimani H, Gurevich A, Prjibelski A, Fisher M, Vargas F, Smarr L, Dorrestein PC, Mylne JS, Pevzner PA Cell systems 31864964 Cell Syst 2020 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/31864964
MS2Planner: improved fragmentation spectra coverage in untargeted mass spectrometry by iterative optimized data acquisition. Zuo Z, Cao L, Nothia LF, Mohimani H Bioinformatics (Oxford, England) 34252948 Bioinformatics 2021 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/34252948
MolDiscovery: learning mass spectrometry fragmentation of small molecules. Cao L, Guler M, Tagirdzhanov A, Lee YY, Gurevich A, Mohimani H Nature communications 34140479 Nat Commun 2021 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/34140479
Feature-based molecular networking in the GNPS analysis environment. Nothias LF, Petras D, Schmid R, Dührkop K, Rainer J, Sarvepalli A, Protsyuk I, Ernst M, Tsugawa H, Fleischauer M, Aicheler F, Aksenov AA, Alka O, Allard PM, Barsch A, Cachet X, Caraballo-Rodriguez AM, Da Silva RR, Dang T, Garg N, Gauglitz JM, Gurevich A, Isaac G, Jarmusch AK, Kameník Z, Kang KB, Kessler N, Koester I, Korf A, Le Gouellec A, Ludwig M, Martin H C, McCall LI, McSayles J, Meyer SW, Mohimani H, Morsy M, Moyne O, Neumann S, Neuweger H, Nguyen NH, Nothias-Esposito M, Paolini J, Phelan VV, Pluskal T, Quinn RA, Rogers S, Shrestha B, Tripathi A, van der Hooft JJJ, Vargas F, Weldon KC, Witting M, Yang H, Zhang Z, Zubeil F, Kohlbacher O, Böcker S, Alexandrov T, Bandeira N, Wang M, Dorrestein PC Nature methods 32839597 Nat Methods 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32839597
An interpretable machine learning approach to identify mechanism of action of antibiotics. Mongia M, Guler M, Mohimani H Scientific reports 35725893 Sci Rep 2022 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/35725893
A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data. Zuffa S, Schmid R, Bauermeister A, Gomes PWP, Caraballo-Rodriguez AM, Abiead YE, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, de Cassia Pessotti R, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Dos Santos MS, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, de León AVP, Pope PB, Rosa SL, Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC Research square 37577622 Res Sq 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37577622
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Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS. Yan D, Zhou M, Adduri A, Zhuang Y, Guler M, Liu S, Shin H, Kovach T, Oh G, Liu X, Deng Y, Wang X, Cao L, Sherman DH, Schultz PJ, Kersten RD, Clement JA, Tripathi A, Behsaz B, Mohimani H Nature communications 38918378 Nat Commun 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38918378
Bacillus subtilis biofilm matrix components target seed oil bodies to promote growth and anti-fungal resistance in melon. Berlanga-Clavero MV, Molina-Santiago C, Caraballo-Rodríguez AM, Petras D, Díaz-Martínez L, Pérez-García A, de Vicente A, Carrión VJ, Dorrestein PC, Romero D Nature microbiology 35668112 Nat Microbiol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35668112
HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search. Lee YY, Guler M, Chigumba DN, Wang S, Mittal N, Miller C, Krummenacher B, Liu H, Cao L, Kannan A, Narayan K, Slocum ST, Roth BL, Gurevich A, Behsaz B, Kersten RD, Mohimani H Nature communications 37452020 Nat Commun 2023 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/37452020
Repository scale classification and decomposition of tandem mass spectral data. Mongia M, Mohimani H Scientific reports 33859284 Sci Rep 2021 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/33859284
EnHiC: learning fine-resolution Hi-C contact maps using a generative adversarial framework. Hu Y, Ma W Bioinformatics (Oxford, England) 34252966 Bioinformatics 2021 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/34252966
Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence. Molina-Santiago C, Vela-Corcía D, Petras D, Díaz-Martínez L, Pérez-Lorente AI, Sopeña-Torres S, Pearson J, Caraballo-Rodríguez AM, Dorrestein PC, de Vicente A, Romero D Cell reports 34320359 Cell Rep 2021 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/34320359
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cao L, Gurevich A, Alexander KL, Naman CB, Leão T, Glukhov E, Luzzatto-Knaan T, Vargas F, Quinn R, Bouslimani A, Nothias LF, Singh NK, Sanders JG, Benitez RAS, Thompson LR, Hamid MN, Morton JT, Mikheenko A, Shlemov A, Korobeynikov A, Friedberg I, Knight R, Venkateswaran K, Gerwick WH, Gerwick L, Dorrestein PC, Pevzner PA, Mohimani H Cell systems 31629686 Cell Syst 2019 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/31629686
TransDiscovery: Discovering Biotransformation from Human Microbiota by Integrating Metagenomic and Metabolomic Data. Yan D, Cao L, Zhou M, Mohimani H Metabolites 35208194 Metabolites 2022 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/35208194
Large scale sequence alignment via efficient inference in generative models. Mongia M, Shen C, Davoodi AG, Marçais G, Mohimani H Scientific reports 37142645 Sci Rep 2023 May 4 https://www.ncbi.nlm.nih.gov/pubmed/37142645
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum. Guna A, Hazu M, Pinton Tomaleri G, Voorhees RM Cold Spring Harbor perspectives in biology 36041783 Cold Spring Harb Perspect Biol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36041783
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Structural basis for membrane insertion by the human ER membrane protein complex. Pleiner T, Tomaleri GP, Januszyk K, Inglis AJ, Hazu M, Voorhees RM Science (New York, N.Y.) 32439656 Science 2020 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/32439656
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM bioRxiv : the preprint server for biology 36711738 bioRxiv 2023 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/36711738
A nanobody-based strategy for rapid and scalable purification of human protein complexes. Stevens TA, Tomaleri GP, Hazu M, Wei S, Nguyen VN, DeKalb C, Voorhees RM, Pleiner T Nature protocols 37974029 Nat Protoc 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37974029
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM BMC genomics 37904134 BMC Genomics 2023 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/37904134
WNK1 is an assembly factor for the human ER membrane protein complex. Pleiner T, Hazu M, Tomaleri GP, Januszyk K, Oania RS, Sweredoski MJ, Moradian A, Guna A, Voorhees RM Molecular cell 33964204 Mol Cell 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/33964204
Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex. Inglis AJ, Page KR, Guna A, Voorhees RM Cell reports 32187542 Cell Rep 2020 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/32187542
3D ATAC-PALM: super-resolution imaging of the accessible genome. Xie L, Dong P, Chen X, Hsieh TS, Banala S, De Marzio M, English BP, Qi Y, Jung SK, Kieffer-Kwon KR, Legant WR, Hansen AS, Schulmann A, Casellas R, Zhang B, Betzig E, Lavis LD, Chang HY, Tjian R, Liu Z Nature methods 32203384 Nat Methods 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32203384
Deep learning enables fast and dense single-molecule localization with high accuracy. Speiser A, Müller LR, Hoess P, Matti U, Obara CJ, Legant WR, Kreshuk A, Macke JH, Ries J, Turaga SC Nature methods 34480155 Nat Methods 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34480155
u-track3D: Measuring, navigating, and validating dense particle trajectories in three dimensions. Roudot P, Legant WR, Zou Q, Dean KM, Isogai T, Welf ES, David AF, Gerlich DW, Fiolka R, Betzig E, Danuser G Cell reports methods 38042149 Cell Rep Methods 2023 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/38042149
A series of spontaneously blinking dyes for super-resolution microscopy. Holland KL, Plutkis SE, Daugird TA, Sau A, Grimm JB, English BP, Zheng Q, Dave S, Rahman F, Xie L, Dong P, Tkachuk AN, Brown TA, Singer RH, Liu Z, Galbraith CG, Musser SM, Legant WR, Lavis LD bioRxiv : the preprint server for biology 38766149 bioRxiv 2024 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/38766149
A multi-functional microfluidic device compatible with widefield and light sheet microscopy. Moore RP, O'Shaughnessy EC, Shi Y, Nogueira AT, Heath KM, Hahn KM, Legant WR Lab on a chip 34859808 Lab Chip 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34859808
Posterior approach to correct for focal plane offsets in lattice light-sheet structured illumination microscopy. Shi Y, Daugird TA, Legant WR Journal of biomedical optics 39086928 J Biomed Opt 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/39086928
Smart lattice light-sheet microscopy for imaging rare and complex cellular events. Shi Y, Tabet JS, Milkie DE, Daugird TA, Yang CQ, Ritter AT, Giovannucci A, Legant WR Nature methods 38167656 Nat Methods 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38167656
Shared and redundant proteins coordinate signal cross-talk between MAPK pathways in yeast. Zhang S, Wang H, Sipko EL, Li S, Daugird TA, Legant WR, Dohlman HG Molecular biology of the cell 39083355 Mol Biol Cell 2024 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/39083355
A quantitative analysis of various patterns applied in lattice light sheet microscopy. Shi Y, Daugird TA, Legant WR Nature communications 35941165 Nat Commun 2022 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/35941165
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment. Daugird TA, Shi Y, Holland KL, Rostamian H, Liu Z, Lavis LD, Rodriguez J, Strahl BD, Legant WR Nature communications 38755200 Nat Commun 2024 May 16 https://www.ncbi.nlm.nih.gov/pubmed/38755200
Phase separation drives aberrant chromatin looping and cancer development. Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH, Wang GG Nature 34163069 Nature 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34163069
Superresolution microscopy reveals actomyosin dynamics in medioapical arrays. Moore RP, Fogerson SM, Tulu US, Yu JW, Cox AH, Sican MA, Li D, Legant WR, Weigel AV, Crawford JM, Betzig E, Kiehart DP Molecular biology of the cell 35544300 Mol Biol Cell 2022 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/35544300
Cell dynamics revealed by microscopy advances. Hockenberry MA, Daugird TA, Legant WR Current opinion in cell biology 39159598 Curr Opin Cell Biol 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39159598
Mapping the nuclear landscape with multiplexed super-resolution fluorescence microscopy. Rahman F, Augoustides V, Tyler E, Daugird TA, Arthur C, Legant WR bioRxiv : the preprint server for biology 39211261 bioRxiv 2024 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/39211261
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Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens. Wu SC, Kamili NA, Dias-Baruffi M, Josephson CD, Rathgeber MF, Yeung MY, Lane WJ, Wang J, Jan HM, Rakoff-Nahoum S, Cummings RD, Stowell SR, Arthur CM iScience 35754739 iScience 2022 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/35754739
Bacterial amylases enable glycogen degradation by the vaginal microbiome. Jenkins DJ, Woolston BM, Hood-Pishchany MI, Pelayo P, Konopaski AN, Quinn Peters M, France MT, Ravel J, Mitchell CM, Rakoff-Nahoum S, Whidbey C, Balskus EP Nature microbiology 37563289 Nat Microbiol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37563289
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The endoplasmic reticulum adopts two distinct tubule forms. Wang B, Zhao Z, Xiong M, Yan R, Xu K Proceedings of the National Academy of Sciences of the United States of America 35471903 Proc Natl Acad Sci U S A 2022 May 3 https://www.ncbi.nlm.nih.gov/pubmed/35471903
Displacement Statistics of Unhindered Single Molecules Show no Enhanced Diffusion in Enzymatic Reactions. Choi AA, Park HH, Chen K, Yan R, Li W, Xu K Journal of the American Chemical Society 35258969 J Am Chem Soc 2022 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/35258969
SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport. Yan R, Chen K, Wang B, Xu K Developmental cell 35051356 Dev Cell 2022 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/35051356
Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates. He C, Wu CY, Li W, Xu K bioRxiv : the preprint server for biology 37503034 bioRxiv 2023 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/37503034
Graphene-Enabled, Spatially Controlled Electroporation of Adherent Cells for Live-Cell Super-resolution Microscopy. Moon S, Li W, Hauser M, Xu K ACS nano 32282180 ACS Nano 2020 May 26 https://www.ncbi.nlm.nih.gov/pubmed/32282180
Single Molecules Are Your Quanta: A Bottom-Up Approach toward Multidimensional Super-resolution Microscopy. Xiang L, Chen K, Xu K ACS nano 34304562 ACS Nano 2021 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/34304562
Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, Reiter JF Cell 33932338 Cell 2021 May 27 https://www.ncbi.nlm.nih.gov/pubmed/33932338
Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells. Jin M, Shirazinejad C, Wang B, Yan A, Schöneberg J, Upadhyayula S, Xu K, Drubin DG Nature communications 35732852 Nat Commun 2022 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/35732852
Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity. Xiang L, Chen K, Yan R, Li W, Xu K Nature methods 32203387 Nat Methods 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32203387
Probing Nanoscale Diffusional Heterogeneities in Cellular Membranes through Multidimensional Single-Molecule and Super-Resolution Microscopy. Yan R, Chen K, Xu K Journal of the American Chemical Society 33084318 J Am Chem Soc 2020 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/33084318
Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing. Chen K, Yan R, Xiang L, Xu K Light, science & applications 33963178 Light Sci Appl 2021 May 8 https://www.ncbi.nlm.nih.gov/pubmed/33963178
Multidimensional Super-Resolution Microscopy Unveils Nanoscale Surface Aggregates in the Aging of FUS Condensates. He C, Wu CY, Li W, Xu K Journal of the American Chemical Society 37782826 J Am Chem Soc 2023 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/37782826
Super-multiplexing excitation spectral microscopy with multiple fluorescence bands. Chen K, Li W, Xu K Biomedical optics express 36733753 Biomed Opt Express 2022 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/36733753
Single-Molecule Spectroscopy and Super-Resolution Mapping of Physicochemical Parameters in Living Cells. Steves MA, He C, Xu K Annual review of physical chemistry 38360526 Annu Rev Phys Chem 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38360526
Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and On-Demand Removal. Kataki-Anastasakou A, Axtell JC, Hernandez S, Dziedzic RM, Balaich GJ, Rheingold AL, Spokoyny AM, Sletten EM Journal of the American Chemical Society 33253553 J Am Chem Soc 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33253553
Expanding the Scope of Palladium-Catalyzed B - N Cross-Coupling Chemistry in Carboranes. Mu X, Hopp M, Dziedzic RM, Waddington MA, Rheingold AL, Sletten EM, Axtell JC, Spokoyny AM Organometallics 34012188 Organometallics 2020 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/34012188
Cell-surface Labeling via Bioorthogonal Host-Guest Chemistry. Kataki-Anastasakou A, Hernandez S, Sletten EM ACS chemical biology 34669367 ACS Chem Biol 2021 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/34669367
Arene-Perfluoroarene Interactions in Solution. Lee GY, Hu E, Rheingold AL, Houk KN, Sletten EM The Journal of organic chemistry 34077211 J Org Chem 2021 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/34077211
Bioorthogonal chemistry: Bridging chemistry, biology, and medicine. Hartung KM, Sletten EM Chem 39006002 Chem 2023 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/39006002
A Fluorescent Unnatural Mannosamine Derivative with Enhanced Emission Upon Complexation with Cucurbit[7]uril. Kataki-Anastasakou A, Jia S, Axtell JC, Sletten EM Israel journal of chemistry 37636996 Isr J Chem 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/37636996
Digital Assembly of Colloidal Particles for Nanoscale Manufacturing. Kotnala A, Zheng Y Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems 33041521 Part Part Syst Charact 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/33041521
Optothermally Assembled Nanostructures. Li J, Zheng Y Accounts of materials research 34396151 Acc Mater Res 2021 May 28 https://www.ncbi.nlm.nih.gov/pubmed/34396151
Liquid Optothermoelectrics: Fundamentals and Applications. Chen Z, Kollipara PS, Ding H, Pughazhendi A, Zheng Y Langmuir : the ACS journal of surfaces and colloids 33410698 Langmuir 2021 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/33410698
Directional Modulation of Exciton Emission Using Single Dielectric Nanospheres. Fang J, Wang M, Yao K, Zhang T, Krasnok A, Jiang T, Choi J, Kahn E, Korgel BA, Terrones M, Li X, Alù A, Zheng Y Advanced materials (Deerfield Beach, Fla.) 33837615 Adv Mater 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33837615
Tunable Chiral Optics in All-Solid-Phase Reconfigurable Dielectric Nanostructures. Li J, Wang M, Wu Z, Li H, Hu G, Jiang T, Guo J, Liu Y, Yao K, Chen Z, Fang J, Fan D, Korgel BA, Alù A, Zheng Y Nano letters 33372805 Nano Lett 2021 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/33372805
All-optical reconfigurable chiral meta-molecules. Lin L, Lepeshov S, Krasnok A, Jiang T, Peng X, Korgel BA, Alù A, Zheng Y Materials today (Kidlington, England) 31777449 Mater Today (Kidlington) 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31777449
Optothermophoretic Manipulation of Colloidal Particles in Nonionic Liquids. Peng X, Lin L, Hill EH, Kunal P, Humphrey SM, Zheng Y The journal of physical chemistry. C, Nanomaterials and interfaces 30766650 J Phys Chem C Nanomater Interfaces 2018 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/30766650
Enhancing Surface Capture and Sensing of Proteins with Low-Power Optothermal Bubbles in a Biphasic Liquid. Kim Y, Ding H, Zheng Y Nano letters 32667815 Nano Lett 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/32667815
Controlling the polarization of chiral dipolar emission with a spherical dielectric nanoantenna. Yao K, Zheng Y The Journal of chemical physics 34911301 J Chem Phys 2021 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/34911301
Room-Temperature Observation of Near-Intrinsic Exciton Linewidth in Monolayer WS(2). Fang J, Yao K, Zhang T, Wang M, Jiang T, Huang S, Korgel BA, Terrones M, Alù A, Zheng Y Advanced materials (Deerfield Beach, Fla.) 35170105 Adv Mater 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35170105
Opto-thermoelectric speckle tweezers. Kotnala A, Kollipara PS, Zheng Y Nanophotonics (Berlin, Germany) 34290954 Nanophotonics 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/34290954
Atomistic modeling and rational design of optothermal tweezers for targeted applications. Ding H, Kollipara PS, Lin L, Zheng Y Nano research 35475031 Nano Res 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/35475031
Tunable Strong Coupling in Transition Metal Dichalcogenide Nanowires. Li J, Yao K, Huang Y, Fang J, Kollipara PS, Fan DE, Zheng Y Advanced materials (Deerfield Beach, Fla.) 35793202 Adv Mater 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35793202
Enhancing Single-Molecule Fluorescence Spectroscopy with Simple and Robust Hybrid Nanoapertures. Kotnala A, Ding H, Zheng Y ACS photonics 35445142 ACS Photonics 2021 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/35445142
Broadband Forward Light Scattering by Architectural Design of Core-Shell Silicon Particles. De Marco ML, Jiang T, Fang J, Lacomme S, Zheng Y, Baron A, Korgel BA, Barois P, Drisko GL, Aymonier C Advanced functional materials 38031546 Adv Funct Mater 2021 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/38031546
Opto-thermophoretic fiber tweezers. Kotnala A, Zheng Y Nanophotonics (Berlin, Germany) 34290953 Nanophotonics 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/34290953
Heat-Mediated Optical Manipulation. Chen Z, Li J, Zheng Y Chemical reviews 34797041 Chem Rev 2022 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/34797041
Overcoming Diffusion-Limited Trapping in Nanoaperture Tweezers Using Opto-Thermal-Induced Flow. Kotnala A, Kollipara PS, Li J, Zheng Y Nano letters 31834809 Nano Lett 2020 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/31834809
Opto-thermoelectric nanotweezers. Lin L, Wang M, Peng X, Lissek EN, Mao Z, Scarabelli L, Adkins E, Coskun S, Unalan HE, Korgel BA, Liz-Marzán LM, Florin EL, Zheng Y Nature photonics 29785202 Nat Photonics 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29785202
Sensitivity-Enhancing Strategies in Optical Biosensing. Kim Y, Gonzales J, Zheng Y Small (Weinheim an der Bergstrasse, Germany) 33369864 Small 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33369864
Directional light emission by electric and magnetic dipoles near a nanosphere: an analytical approach based on the generalized Mie theory. Yao K, Zheng Y Optics letters 33449012 Opt Lett 2021 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/33449012
Opto-refrigerative tweezers. Li J, Chen Z, Liu Y, Kollipara PS, Feng Y, Zhang Z, Zheng Y Science advances 34172454 Sci Adv 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34172454
Bubble-pen lithography: Fundamentals and applications: Nanoscience: Special Issue Dedicated to Professor Paul S. Weiss. Kollipara PS, Mahendra R, Li J, Zheng Y Aggregate (Hoboken, N.J.) 37441005 Aggregate (Hoboken) 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/37441005
Deep Convolutional Mixture Density Network for Inverse Design of Layered Photonic Structures. Unni R, Yao K, Zheng Y ACS photonics 38031541 ACS Photonics 2020 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/38031541
Light-driven C-H activation mediated by 2D transition metal dichalcogenides. Li J, Zhang D, Guo Z, Chen Z, Jiang X, Larson JM, Zhu H, Zhang T, Gu Y, Blankenship BW, Chen M, Wu Z, Huang S, Kostecki R, Minor AM, Grigoropoulos CP, Akinwande D, Terrones M, Redwing JM, Li H, Zheng Y Nature communications 38956055 Nat Commun 2024 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/38956055
Opto-Thermophoretic Attraction, Trapping, and Dynamic Manipulation of Lipid Vesicles. Hill EH, Li J, Lin L, Liu Y, Zheng Y Langmuir : the ACS journal of surfaces and colloids 30350700 Langmuir 2018 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/30350700
Opto-thermoelectric microswimmers. Peng X, Chen Z, Kollipara PS, Liu Y, Fang J, Lin L, Zheng Y Light, science & applications 32864116 Light Sci Appl 2020 https://www.ncbi.nlm.nih.gov/pubmed/32864116
Suppressing material loss in the visible and near-infrared range for functional nanophotonics using bandgap engineering. Wang M, Krasnok A, Lepeshov S, Hu G, Jiang T, Fang J, Korgel BA, Alù A, Zheng Y Nature communications 33028825 Nat Commun 2020 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/33028825
Thermo-Electro-Mechanics at Individual Particles in Complex Colloidal Systems. Kollipara PS, Lin L, Zheng Y The journal of physical chemistry. C, Nanomaterials and interfaces 32913480 J Phys Chem C Nanomater Interfaces 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/32913480
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Optical nanomanipulation on solid substrates via optothermally-gated photon nudging. Li J, Liu Y, Lin L, Wang M, Jiang T, Guo J, Ding H, Kollipara PS, Inoue Y, Fan D, Korgel BA, Zheng Y Nature communications 31831746 Nat Commun 2019 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/31831746
Intelligent nanophotonics: merging photonics and artificial intelligence at the nanoscale. Yao K, Unni R, Zheng Y Nanophotonics (Berlin, Germany) 34290952 Nanophotonics 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/34290952
Plasmonic Nanotweezers and Nanosensors for Point-of-Care Applications. Peng X, Kotnala A, Rajeeva BB, Wang M, Yao K, Bhatt N, Penley D, Zheng Y Advanced optical materials 34434691 Adv Opt Mater 2021 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/34434691
Label-Free Ultrasensitive Detection of Abnormal Chiral Metabolites in Diabetes. Liu Y, Wu Z, Kollipara PS, Montellano R, Sharma K, Zheng Y ACS nano 33760602 ACS Nano 2021 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/33760602
Opto-Thermoelectric Tweezers: Principles and Applications. Pughazhendi A, Chen Z, Wu Z, Li J, Zheng Y Frontiers in physics 38031585 Front Phys 2020 https://www.ncbi.nlm.nih.gov/pubmed/38031585
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Light-driven single-cell rotational adhesion frequency assay. Liu Y, Ding H, Li J, Lou X, Yang M, Zheng Y eLight 35965781 eLight 2022 https://www.ncbi.nlm.nih.gov/pubmed/35965781
Universal optothermal micro/nanoscale rotors. Ding H, Kollipara PS, Kim Y, Kotnala A, Li J, Chen Z, Zheng Y Science advances 35704582 Sci Adv 2022 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/35704582
Decoding Optical Data with Machine Learning. Fang J, Swain A, Unni R, Zheng Y Laser & photonics reviews 34539925 Laser Photon Rev 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/34539925
Digital manufacturing of advanced materials: challenges and perspective. Lin L, Kollipara PS, Zheng Y Materials today (Kidlington, England) 32831619 Mater Today (Kidlington) 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/32831619
Optothermal Manipulations of Colloidal Particles and Living Cells. Lin L, Hill EH, Peng X, Zheng Y Accounts of chemical research 29799720 Acc Chem Res 2018 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/29799720
Nanoradiator-Mediated Deterministic Opto-Thermoelectric Manipulation. Liu Y, Lin L, Bangalore Rajeeva B, Jarrett JW, Li X, Peng X, Kollipara P, Yao K, Akinwande D, Dunn AK, Zheng Y ACS nano 30226980 ACS Nano 2018 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/30226980
Optical Nanoprinting of Colloidal Particles and Functional Structures. Li J, Hill EH, Lin L, Zheng Y ACS nano 30875190 ACS Nano 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/30875190
Evolutionary Engineering a Larger Porin Using a Loop-to-Hairpin Mechanism. Dhar R, Bowman AM, Hatungimana B, Sg Slusky J Journal of molecular biology 37769963 J Mol Biol 2023 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/37769963
MAHOMES II: A webserver for predicting if a metal binding site is enzymatic. Feehan R, Copeland M, Franklin MW, Slusky JSG bioRxiv : the preprint server for biology 36945603 bioRxiv 2023 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/36945603
Colicin E1 opens its hinge to plug TolC. Budiardjo SJ, Stevens JJ, Calkins AL, Ikujuni AP, Wimalasena VK, Firlar E, Case DA, Biteen JS, Kaelber JT, Slusky JSG eLife 35199644 Elife 2022 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/35199644
Machine learning for enzyme engineering, selection and design. Feehan R, Montezano D, Slusky JSG Protein engineering, design & selection : PEDS 34296736 Protein Eng Des Sel 2021 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/34296736
Tight Turns of Outer Membrane Proteins: An Analysis of Sequence, Structure, and Hydrogen Bonding. Franklin MW, Slusky JSG Journal of molecular biology 29944853 J Mol Biol 2018 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/29944853
Efflux Pumps Represent Possible Evolutionary Convergence onto the β-Barrel Fold. Franklin MW, Nepomnyachiy S, Feehan R, Ben-Tal N, Kolodny R, Slusky JSG Structure (London, England : 1993) 30057025 Structure 2018 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/30057025
General features of transmembrane beta barrels from a large database. Montezano D, Bernstein R, Copeland MM, Slusky JSG Proceedings of the National Academy of Sciences of the United States of America 37432995 Proc Natl Acad Sci U S A 2023 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/37432995
Machine learning differentiates enzymatic and non-enzymatic metals in proteins. Feehan R, Franklin MW, Slusky JSG Nature communications 34140507 Nat Commun 2021 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/34140507
MAHOMES II: A webserver for predicting if a metal binding site is enzymatic. Feehan R, Copeland M, Franklin MW, Slusky JSG Protein science : a publication of the Protein Society 36916762 Protein Sci 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36916762
Membrane Barrels Are Taller, Fatter, Inside-Out Soluble Barrels. Dhar R, Feehan R, Slusky JSG The journal of physical chemistry. B 33797916 J Phys Chem B 2021 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/33797916
High-Yield Preparation of Outer Membrane Protein Efflux Pumps by in Vitro Refolding is Concentration Dependent. Budiardjo SJ, Ikujuni AP, Firlar E, Cordova A, Kaelber JT, Slusky JSG The Journal of membrane biology 33462665 J Membr Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33462665
Outer membrane protein evolution. Dhar R, Slusky JS Current opinion in structural biology 33493965 Curr Opin Struct Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33493965
Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis. Ikujuni AP, Dhar R, Cordova A, Bowman AM, Noga S, Slusky JSG Journal of molecular biology 38871177 J Mol Biol 2024 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/38871177
Tuning Optical Absorption and Emission Using Strongly Coupled Dimers in Programmable DNA Scaffolds. Hart SM, Wang X, Guo J, Bathe M, Schlau-Cohen GS The journal of physical chemistry letters 35175058 J Phys Chem Lett 2022 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/35175058
Observation of robust energy transfer in the photosynthetic protein allophycocyanin using single-molecule pump-probe spectroscopy. Moya R, Norris AC, Kondo T, Schlau-Cohen GS Nature chemistry 34992285 Nat Chem 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34992285
Concerted Differential Changes of Helical Dynamics and Packing upon Ligand Occupancy in a Bacterial Chemoreceptor. Gordon JB, Hoffman MC, Troiano JM, Li M, Hazelbauer GL, Schlau-Cohen GS ACS chemical biology 34647725 ACS Chem Biol 2021 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/34647725
Nanoscale 3D spatial addressing and valence control of quantum dots using wireframe DNA origami. Chen C, Wei X, Parsons MF, Guo J, Banal JL, Zhao Y, Scott MN, Schlau-Cohen GS, Hernandez R, Bathe M Nature communications 35999227 Nat Commun 2022 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/35999227
Observation of conformational dynamics in single light-harvesting proteins from cryptophyte algae. Moya R, Norris AC, Spangler LC, Scholes GD, Schlau-Cohen GS The Journal of chemical physics 35868944 J Chem Phys 2022 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/35868944
Phosphorylation-Dependent Conformations of the Disordered Carboxyl-Terminus Domain in the Epidermal Growth Factor Receptor. Regmi R, Srinivasan S, Latham AP, Kukshal V, Cui W, Zhang B, Bose R, Schlau-Cohen GS The journal of physical chemistry letters 33179922 J Phys Chem Lett 2020 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/33179922
Spectrally-tunable femtosecond single-molecule pump-probe spectroscopy. Moya R, Kondo T, Norris AC, Schlau-Cohen GS Optics express 34614960 Opt Express 2021 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/34614960
Ligand-induced transmembrane conformational coupling in monomeric EGFR. Srinivasan S, Regmi R, Lin X, Dreyer CA, Chen X, Quinn SD, He W, Coleman MA, Carraway KL 3rd, Zhang B, Schlau-Cohen GS Nature communications 35794108 Nat Commun 2022 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/35794108
Versatile Peptide Macrocyclization with Diels-Alder Cycloadditions. Montgomery JE, Donnelly JA, Fanning SW, Speltz TE, Shangguan X, Coukos JS, Greene GL, Moellering RE Journal of the American Chemical Society 31523967 J Am Chem Soc 2019 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/31523967
Diels-Alder Cycloadditions for Peptide Macrocycle Formation. Montgomery JE, Moellering RE Methods in molecular biology (Clifton, N.J.) 34596848 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/34596848
Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Speltz TE, Qiao Z, Swenson CS, Shangguan X, Coukos JS, Lee CW, Thomas DM, Santana J, Fanning SW, Greene GL, Moellering RE Nature biotechnology 36302987 Nat Biotechnol 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36302987
High throughput discovery of functional protein modifications by Hotspot Thermal Profiling. Huang JX, Lee G, Cavanaugh KE, Chang JW, Gardel ML, Moellering RE Nature methods 31384043 Nat Methods 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31384043
Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Qiao Z, Nguyen LC, Yang D, Dann C, Thomas DM, Henn M, Valdespino A, Swenson CS, Oakes SA, Rosner MR, Moellering RE Nature chemical biology 39215099 Nat Chem Biol 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39215099
An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Li G, Montgomery JE, Eckert MA, Chang JW, Tienda SM, Lengyel E, Moellering RE Nature communications 29176560 Nat Commun 2017 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/29176560
Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation. Li G, Eckert MA, Chang JW, Montgomery JE, Chryplewicz A, Lengyel E, Moellering RE Proceedings of the National Academy of Sciences of the United States of America 31591248 Proc Natl Acad Sci U S A 2019 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/31591248
Photoproximity Profiling of Protein-Protein Interactions in Cells. McCutcheon DC, Lee G, Carlos A, Montgomery JE, Moellering RE Journal of the American Chemical Society 31820968 J Am Chem Soc 2020 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/31820968
A Concise, Modular Antibody-Oligonucleotide Conjugation Strategy Based on Disuccinimidyl Ester Activation Chemistry. Li G, Moellering RE Chembiochem : a European journal of chemical biology 30767357 Chembiochem 2019 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/30767357
Evolving artificial metalloenzymes via random mutagenesis. Yang H, Swartz AM, Park HJ, Srivastava P, Ellis-Guardiola K, Upp DM, Lee G, Belsare K, Gu Y, Zhang C, Moellering RE, Lewis JC Nature chemistry 29461523 Nat Chem 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29461523
Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in Cancer. Carlos AJ, Yang D, Thomas DM, Huang S, Harter KI, Moellering RE bioRxiv : the preprint server for biology 39345550 bioRxiv 2024 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/39345550
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaženović I, Lastra RR, Curtis M, Yamada SD, Perets R, McGregor SM, Andrade J, Fiehn O, Moellering RE, Mann M, Lengyel E Nature 31043742 Nature 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31043742
Chemoproteomic Profiling of Phosphoaspartate Modifications in Prokaryotes. Chang JW, Montgomery JE, Lee G, Moellering RE Angewandte Chemie (International ed. in English) 30231186 Angew Chem Int Ed Engl 2018 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/30231186
Chemical probes for spatially resolved measurement of active enzymes in single cells. Li G, Moellering RE Methods in enzymology 31668232 Methods Enzymol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31668232
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE Nature 30323285 Nature 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30323285
Spectroscopy-Assisted Label-free Molecular Analysis of Live Cell Surface with Vertically Aligned Plasmonic Nanopillars. Zhang C, Siddhanta S, Paria D, Li Y, Zheng C, Barman I Small (Weinheim an der Bergstrasse, Germany) 33942486 Small 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33942486
Integration of diffraction phase microscopy and Raman imaging for label-free morpho-molecular assessment of live cells. Pandey R, Zhou R, Bordett R, Hunter C, Glunde K, Barman I, Valdez T, Finck C Journal of biophotonics 30421505 J Biophotonics 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30421505
Plexcitonic Quasi-Bound States in the Continuum. Zheng P, Raj P, Mizutani T, Szabo M, Hanson WA, Barman I Small (Weinheim an der Bergstrasse, Germany) 34411423 Small 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34411423
Self-Folding Hybrid Graphene Skin for 3D Biosensing. Xu W, Paidi SK, Qin Z, Huang Q, Yu CH, Pagaduan JV, Buehler MJ, Barman I, Gracias DH Nano letters 30433789 Nano Lett 2019 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/30433789
Raman spectroscopy reveals phenotype switches in breast cancer metastasis. Paidi SK, Troncoso JR, Harper MG, Liu Z, Nguyen KG, Ravindranathan S, Rebello L, Lee DE, Ivers JD, Zaharoff DA, Rajaram N, Barman I Theranostics 35910801 Theranostics 2022 https://www.ncbi.nlm.nih.gov/pubmed/35910801
Silver-Coated Disordered Silicon Nanowires Provide Highly Sensitive Label-Free Glycated Albumin Detection through Molecular Trapping and Plasmonic Hotspot Formation. Paria D, Convertino A, Mussi V, Maiolo L, Barman I Advanced healthcare materials 33236490 Adv Healthc Mater 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33236490
Surface-enhanced Raman scattering: An emerging tool for sensing cellular function. Tanwar S, Kim JH, Bulte JWM, Barman I Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 35510405 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35510405
Label-Free Vibrational and Quantitative Phase Microscopy Reveals Remarkable Pathogen-Induced Morphomolecular Divergence in Tumor-Derived Cells. Liu Z, Parida S, Wu S, Sears CL, Sharma D, Barman I ACS sensors 35583030 ACS Sens 2022 May 27 https://www.ncbi.nlm.nih.gov/pubmed/35583030
Towards rational design and optimization of near-field enhancement and spectral tunability of hybrid core-shell plasmonic nanoprobes. Paria D, Zhang C, Barman I Scientific reports 31690763 Sci Rep 2019 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/31690763
A Smart Intracellular Self-Assembling Bioorthogonal Raman Active Nanoprobe for Targeted Tumor Imaging. Tanwar S, Ghaemi B, Raj P, Singh A, Wu L, Yuan Y, Arifin DR, McMahon MT, Bulte JWM, Barman I Advanced science (Weinheim, Baden-Wurttemberg, Germany) 37715297 Adv Sci (Weinh) 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37715297
Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy. Tanwar S, Wu L, Zahn N, Raj P, Ghaemi B, Chatterjee A, Bulte JWM, Barman I Nano letters 37154678 Nano Lett 2023 May 24 https://www.ncbi.nlm.nih.gov/pubmed/37154678
Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples. Pandey R, Singh SP, Zhang C, Horowitz GL, Lue N, Galindo L, Dasari RR, Barman I Journal of biophotonics 29726123 J Biophotonics 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29726123
Rapid, Label-free Optical Spectroscopy Platform for Diagnosis of Heparin-Induced Thrombocytopenia. Huang Z, Siddhanta S, Zheng G, Kickler T, Barman I Angewandte Chemie (International ed. in English) 31972060 Angew Chem Int Ed Engl 2020 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/31972060
Label-Free Spectroscopic SARS-CoV-2 Detection on Versatile Nanoimprinted Substrates. Paria D, Kwok KS, Raj P, Zheng P, Gracias DH, Barman I Nano letters 35348344 Nano Lett 2022 May 11 https://www.ncbi.nlm.nih.gov/pubmed/35348344
A Dual-Modal Single-Antibody Plasmonic Spectro-Immunoassay for Detection of Small Molecules. Zheng P, Wu L, Raj P, Mizutani T, Szabo M, Hanson WA, Barman I Small (Weinheim an der Bergstrasse, Germany) 35373504 Small 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35373504
Nanowire Assisted Mechanotyping of Cellular Metastatic Potential. Paria D, Convertino A, Raj P, Glunde K, Chen Y, Barman I Advanced functional materials 34512229 Adv Funct Mater 2021 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/34512229
Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential. Paidi SK, Shah V, Raj P, Glunde K, Pandey R, Barman I Biosensors & bioelectronics 33272866 Biosens Bioelectron 2021 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/33272866
Optical properties of symmetry-breaking tetrahedral nanoparticles. Zheng P , Paria D , Wang H , Li M , Barman I Nanoscale 31830188 Nanoscale 2020 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/31830188
Identification and Staging of B-Cell Acute Lymphoblastic Leukemia Using Quantitative Phase Imaging and Machine Learning. Ayyappan V, Chang A, Zhang C, Paidi SK, Bordett R, Liang T, Barman I, Pandey R ACS sensors 33092347 ACS Sens 2020 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/33092347
Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy. Zhang C, Springall JS, Wang X, Barman I Analytica chimica acta 31446951 Anal Chim Acta 2019 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/31446951
Composite-Scattering Plasmonic Nanoprobes for Label-Free, Quantitative Biomolecular Sensing. Zhang C, Paria D, Semancik S, Barman I Small (Weinheim an der Bergstrasse, Germany) 31394029 Small 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31394029
Mapping the genetic basis of breast microcalcifications and their role in metastasis. Rizwan A, Paidi SK, Zheng C, Cheng M, Barman I, Glunde K Scientific reports 30038419 Sci Rep 2018 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/30038419
Shedding Light on the Trehalose-Enabled Mucopermeation of Nanoparticles with Label-Free Raman Spectroscopy. Siddhanta S, Bhattacharjee S, Harrison SM, Scholz D, Barman I Small (Weinheim an der Bergstrasse, Germany) 31267720 Small 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31267720
Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning. Karandikar SH, Zhang C, Meiyappan A, Barman I, Finck C, Srivastava PK, Pandey R Analytical chemistry 30741527 Anal Chem 2019 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/30741527
A Programmable DNA-Silicification-Based Nanocavity for Single-Molecule Plasmonic Sensing. Liang L, Zheng P, Zhang C, Barman I Advanced materials (Deerfield Beach, Fla.) 33458901 Adv Mater 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33458901
Vibrational spectroscopy for decoding cancer microbiota interactions: Current evidence and future perspective. Liu Z, Parida S, Prasad R, Pandey R, Sharma D, Barman I Seminars in cancer biology 34273519 Semin Cancer Biol 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/34273519
Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia. Paidi SK, Raj P, Bordett R, Zhang C, Karandikar SH, Pandey R, Barman I Biosensors & bioelectronics 34130086 Biosens Bioelectron 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34130086
Leveraging Nanomechanical Perturbations in Raman Spectro-Immunoassays to Design a Versatile Serum Biomarker Detection Platform. Zheng P, Raj P, Wu L, Szabo M, Hanson WA, Mizutani T, Barman I Small (Weinheim an der Bergstrasse, Germany) 36117050 Small 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/36117050
Label-Free Morpho-Molecular Imaging for Studying the Differential Interaction of Black Phosphorus with Tumor Cells. Mussi V, Fasolino I, Paria D, De Simone S, Caporali M, Serrano-Ruiz M, Ambrosio L, Barman I, Raucci MG, Convertino A Nanomaterials (Basel, Switzerland) 35745333 Nanomaterials (Basel) 2022 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/35745333
Hyperspectral Raman Imaging for Automated Recognition of Human Renal Amyloid. Kim JH, Zhang C, Sperati CJ, Barman I, Bagnasco SM The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 37833851 J Histochem Cytochem 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37833851
RaMALDI: Enabling simultaneous Raman and MALDI imaging of the same tissue section. Yang E, Kim JH, Tressler CM, Shen XE, Brown DR, Johnson CC, Hahm TH, Barman I, Glunde K Biosensors & bioelectronics 37597501 Biosens Bioelectron 2023 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/37597501
Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells. Bresci A, Kim JH, Ghislanzoni S, Manetti F, Wu L, Vernuccio F, Ceconello C, Sorrentino S, Barman I, Bongarzone I, Cerullo G, Vanna R, Polli D Science advances 37703362 Sci Adv 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37703362
Optical diffraction tomography and Raman spectroscopy reveal distinct cellular phenotypes during white and brown adipocyte differentiation. Anantha P, Liu Z, Raj P, Barman I Biosensors & bioelectronics 37207582 Biosens Bioelectron 2023 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/37207582
Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment. Paidi SK, Diaz PM, Dadgar S, Jenkins SV, Quick CM, Griffin RJ, Dings RPM, Rajaram N, Barman I Cancer research 30819665 Cancer Res 2019 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/30819665
A Fluorescence and Surface-Enhanced Raman Spectroscopic Dual-Modal Aptasensor for Sensitive Detection of Cyanotoxins. Li M, Lin H, Paidi SK, Mesyngier N, Preheim S, Barman I ACS sensors 32314582 ACS Sens 2020 May 22 https://www.ncbi.nlm.nih.gov/pubmed/32314582
Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy. Paidi SK, Rodriguez Troncoso J, Raj P, Monterroso Diaz P, Ivers JD, Lee DE, Avaritt NL, Gies AJ, Quick CM, Byrum SD, Tackett AJ, Rajaram N, Barman I Cancer research 34645610 Cancer Res 2021 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/34645610
Decoding Live Cell Interactions with Multi-Nanoparticle Systems: Differential Implications for Uptake, Trafficking, and Gene Regulation. Liang L, Liu Z, Barman I ACS applied materials & interfaces 31436085 ACS Appl Mater Interfaces 2019 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/31436085
Ultrasensitive Detection of Hepatotoxic Microcystin Production from Cyanobacteria Using Surface-Enhanced Raman Scattering Immunosensor. Li M, Paidi SK, Sakowski E, Preheim S, Barman I ACS sensors 30990314 ACS Sens 2019 May 24 https://www.ncbi.nlm.nih.gov/pubmed/30990314
Molecular Radiative Energy Shifts under Strong Oscillating Fields. Zheng P, Kang J, Paria D, Kang JU, Barman I Small (Weinheim an der Bergstrasse, Germany) 33354911 Small 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33354911
Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors. Yuan Y, Raj P, Zhang J, Siddhanta S, Barman I, Bulte JWM Angewandte Chemie (International ed. in English) 33325142 Angew Chem Int Ed Engl 2021 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/33325142
Cancer cells display increased migration and deformability in pace with metastatic progression. Liu Z, Lee SJ, Park S, Konstantopoulos K, Glunde K, Chen Y, Barman I FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32463148 FASEB J 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32463148
Non-Perturbative Identification and Subtyping of Amyloidosis in Human Kidney Tissue with Raman Spectroscopy and Machine Learning. Kim JH, Zhang C, Sperati CJ, Bagnasco SM, Barman I Biosensors 37185541 Biosensors (Basel) 2023 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/37185541
Engineering vascularized skin-mimetic phantom for non-invasive Raman spectroscopy. Raj P, Wu L, Arora S, Bhatt R, Zuo Y, Fang Z, Verdoold R, Koch T, Gu L, Barman I Sensors and actuators. B, Chemical 38524639 Sens Actuators B Chem 2024 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/38524639
Pyramidal hyperbolic metasurfaces enhance spontaneous emission of nitrogen-vacancy centers in nanodiamond. Zheng P, Liang L, Arora S, Ray K, Semancik S, Barman I Advanced optical materials 37920689 Adv Opt Mater 2023 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/37920689
Quantitative Detection of Thyroid-Stimulating Hormone in Patient Samples with a Nanomechanical Single-Antibody Spectro-Immunoassay. Zheng P, Raj P, Wu L, Mizutani T, Szabo M, Hanson WA, Barman I Small (Weinheim an der Bergstrasse, Germany) 37752776 Small 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37752776
Mechanical expansion microscopy. Fan Y, Lim Y, Wyss LS, Park S, Xu C, Fu H, Fei J, Hong Y, Wang B Methods in cell biology 33478686 Methods Cell Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33478686
RNA Localization in Bacteria. Fei J, Sharma CM Microbiology spectrum 30191804 Microbiol Spectr 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30191804
Continuous active development of super-resolution fluorescence microscopy. Wang Y, Fei J Physical biology 32066124 Phys Biol 2020 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/32066124
Kinetic modeling reveals additional regulation at co-transcriptional level by post-transcriptional sRNA regulators. Reyer MA, Chennakesavalu S, Heideman EM, Ma X, Bujnowska M, Hong L, Dinner AR, Vanderpool CK, Fei J Cell reports 34592145 Cell Rep 2021 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/34592145
Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells. Park S, Prévost K, Heideman EM, Carrier MC, Azam MS, Reyer MA, Liu W, Massé E, Fei J eLife 33616037 Elife 2021 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/33616037
Translational T-box riboswitches bind tRNA by modulating conformational flexibility. Campos-Chavez E, Paul S, Zhou Z, Alonso D, Verma AR, Fei J, Mondragón A Nature communications 39097611 Nat Commun 2024 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/39097611
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency. Wu J, Xiao Y, Liu Y, Wen L, Jin C, Liu S, Paul S, He C, Regev O, Fei J Science advances 39413186 Sci Adv 2024 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/39413186
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. Lerner E, Barth A, Hendrix J, Ambrose B, Birkedal V, Blanchard SC, Börner R, Sung Chung H, Cordes T, Craggs TD, Deniz AA, Diao J, Fei J, Gonzalez RL, Gopich IV, Ha T, Hanke CA, Haran G, Hatzakis NS, Hohng S, Hong SC, Hugel T, Ingargiola A, Joo C, Kapanidis AN, Kim HD, Laurence T, Lee NK, Lee TH, Lemke EA, Margeat E, Michaelis J, Michalet X, Myong S, Nettels D, Peulen TO, Ploetz E, Razvag Y, Robb NC, Schuler B, Soleimaninejad H, Tang C, Vafabakhsh R, Lamb DC, Seidel CA, Weiss S eLife 33779550 Elife 2021 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/33779550
An Improved Method for Bacterial Immunofluorescence Staining To Eliminate Antibody Exclusion from the Fixed Nucleoid. Park S, Reyer MA, McLean EL, Liu W, Fei J Biochemistry 31657208 Biochemistry 2019 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/31657208
Deoxyribozyme-based method for absolute quantification of N(6)-methyladenosine fractions at specific sites of RNA. Bujnowska M, Zhang J, Dai Q, Heideman EM, Fei J The Journal of biological chemistry 32269077 J Biol Chem 2020 May 15 https://www.ncbi.nlm.nih.gov/pubmed/32269077
RNA molecules display distinctive organization at nuclear speckles. Paul S, Arias MA, Wen L, Liao SE, Zhang J, Wang X, Regev O, Fei J iScience 38638569 iScience 2024 May 17 https://www.ncbi.nlm.nih.gov/pubmed/38638569
Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F. Le T, Le SC, Zhang Y, Liang P, Yang H The Journal of biological chemistry 32709749 J Biol Chem 2020 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/32709749
Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury. Zhou Q, Doherty J, Akk A, Springer LE, Fan P, Spasojevic I, Halade GV, Yang H, Pham CTN, Wickline SA, Pan H Nanomaterials (Basel, Switzerland) 35159680 Nanomaterials (Basel) 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/35159680
PIEZO1 Drives Trophoblast Fusion and Placental Development. Zhang Y, Shan KZ, Liang P, Lowry AJ, Feng L, Yang H bioRxiv : the preprint server for biology 40196526 bioRxiv 2025 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/40196526
Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis. Liang P, Zhang Y, Wan YCS, Ma S, Dong P, Lowry AJ, Francis SJ, Khandelwal S, Delahunty M, Telen MJ, Strouse JJ, Arepally GM, Yang H Blood 38033286 Blood 2024 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/38033286
An inner activation gate controls TMEM16F phospholipid scrambling. Le T, Jia Z, Le SC, Zhang Y, Chen J, Yang H Nature communications 31015464 Nat Commun 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/31015464
Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases. Le SC, Liang P, Lowry AJ, Yang H Frontiers in physiology 34867487 Front Physiol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34867487
Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel. Zhou Y, Yang H, Cui J, Lingle CJ The Journal of general physiology 29025867 J Gen Physiol 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/29025867
TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development. Zhang Y, Le T, Grabau R, Mohseni Z, Kim H, Natale DR, Feng L, Pan H, Yang H Science advances 32494719 Sci Adv 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32494719
A simple and robust fluorescent labeling method to quantify trophoblast fusion. Zhang Y, Yang H Placenta 30827351 Placenta 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30827351
An Additional Ca(2+) Binding Site Allosterically Controls TMEM16A Activation. Le SC, Yang H Cell reports 33378669 Cell Rep 2020 Dec 29 https://www.ncbi.nlm.nih.gov/pubmed/33378669
Molecular basis of PIP(2)-dependent regulation of the Ca(2+)-activated chloride channel TMEM16A. Le SC, Jia Z, Chen J, Yang H Nature communications 31434906 Nat Commun 2019 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/31434906
Molecular underpinning of intracellular pH regulation on TMEM16F. Liang P, Yang H The Journal of general physiology 33346788 J Gen Physiol 2021 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/33346788
Niclosamide potentiates TMEM16A and induces vasoconstriction. Liang P, Wan YCS, Yu K, Hartzell HC, Yang H The Journal of general physiology 38814250 J Gen Physiol 2024 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/38814250
Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. Le T, Le SC, Yang H The Journal of biological chemistry 30700552 J Biol Chem 2019 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/30700552
Structure-Function of TMEM16 Ion Channels and Lipid Scramblases. Le SC, Yang H Advances in experimental medicine and biology 35138612 Adv Exp Med Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/35138612
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. Zhang Y, Liang P, Yang L, Shan KZ, Feng L, Chen Y, Liedtke W, Coyne CB, Yang H eLife 35670667 Elife 2022 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/35670667
Trophoblast organoids with physiological polarity model placental structure and function. Yang L, Liang P, Yang H, Coyne CB Journal of cell science 37676312 J Cell Sci 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/37676312
TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids. Lowry AJ, Liang P, Song M, Serena Wan YC, Pei ZM, Yang H, Zhang Y bioRxiv : the preprint server for biology 38370744 bioRxiv 2024 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/38370744
Niclosamide potentiates TMEM16A and induces vasoconstriction. Liang P, Wan YCS, Yu K, Hartzell HC, Yang H bioRxiv : the preprint server for biology 37577682 bioRxiv 2023 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/37577682
Trophoblast organoids with physiological polarity model placental structure and function. Yang L, Liang P, Yang H, Coyne CB bioRxiv : the preprint server for biology 36711688 bioRxiv 2023 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/36711688
TMEM16F scramblase regulates angiogenesis via endothelial intracellular signaling. Shan KZ, Le T, Liang P, Dong P, Lowry AJ, Kremmyda P, Claesson-Welsh L, Yang H Journal of cell science 38940198 J Cell Sci 2024 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/38940198
TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids. Lowry AJ, Liang P, Song M, Wan Y, Pei ZM, Yang H, Zhang Y eLife 39495104 Elife 2024 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/39495104
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY Science (New York, N.Y.) 30733385 Science 2019 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/30733385
Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Zubcevic L, Le S, Yang H, Lee SY Nature structural & molecular biology 29728656 Nat Struct Mol Biol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29728656
Corrigendum to "A simple and robust fluorescent labeling method to quantify trophoblast fusion" [Placenta 77 (2019) 16-18]. Zhang Y, Yang H Placenta 31130263 Placenta 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31130263
Endothelial TMEM16F lipid scramblase regulates angiogenesis. Shan KZ, Le T, Liang P, Dong P, Yang H bioRxiv : the preprint server for biology 37645870 bioRxiv 2023 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/37645870
Improved Yield for the Enzymatic Synthesis of Radiolabeled Nicotinamide Adenine Dinucleotide. Eller J, Goyal S, Cambronne XA ACS bio & med chem Au 36820310 ACS Bio Med Chem Au 2023 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/36820310
SLC25A51 decouples the mitochondrial NAD(+)/NADH ratio to control proliferation of AML cells. Lu MJ, Busquets J, Impedovo V, Wilson CN, Chan HR, Chang YT, Matsui W, Tiziani S, Cambronne XA Cell metabolism 38354740 Cell Metab 2024 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/38354740
Dynamics of SLC25A51 reveal preference for oxidized NAD(+) and substrate led transport. Goyal S, Paspureddi A, Lu MJ, Chan HR, Lyons SN, Wilson CN, Niere M, Ziegler M, Cambronne XA EMBO reports 37575034 EMBO Rep 2023 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/37575034
Methods for Using a Genetically Encoded Fluorescent Biosensor to Monitor Nuclear NAD<sup/>. Cohen MS, Stewart ML, Goodman RH, Cambronne XA Methods in molecular biology (Clifton, N.J.) 30097882 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30097882
Location, Location, Location: Compartmentalization of NAD(+) Synthesis and Functions in Mammalian Cells. Cambronne XA, Kraus WL Trends in biochemical sciences 32595066 Trends Biochem Sci 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32595066
SLC25A51 is a mammalian mitochondrial NAD(+) transporter. Luongo TS, Eller JM, Lu MJ, Niere M, Raith F, Perry C, Bornstein MR, Oliphint P, Wang L, McReynolds MR, Migaud ME, Rabinowitz JD, Johnson FB, Johnsson K, Ziegler M, Cambronne XA, Baur JA Nature 32906142 Nature 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32906142
The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions. Fu Z, Kim H, Morse PT, Lu MJ, Hüttemann M, Cambronne XA, Zhang K, Zhang R Metabolism: clinical and experimental 35932995 Metabolism 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35932995
Pharmacological bypass of NAD(+) salvage pathway protects neurons from chemotherapy-induced degeneration. Liu HW, Smith CB, Schmidt MS, Cambronne XA, Cohen MS, Migaud ME, Brenner C, Goodman RH Proceedings of the National Academy of Sciences of the United States of America 30257945 Proc Natl Acad Sci U S A 2018 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/30257945
Flow Cytometry Analysis of Free Intracellular NAD(+) Using a Targeted Biosensor. Eller JM, Stewart ML, Slepian AJ, Markwardt S, Wiedrick J, Cohen MS, Goodman RH, Cambronne XA Current protocols in cytometry 30556645 Curr Protoc Cytom 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30556645
Layered mechanisms regulating the human mitochondrial NAD+ transporter SLC25A51. Goyal S, Cambronne XA Biochemical Society transactions 38108469 Biochem Soc Trans 2023 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/38108469
Micron-scale geometrical features of microtubules as regulators of microtubule organization. Mani N, Wijeratne SS, Subramanian R eLife 34114950 Elife 2021 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/34114950
Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7. Jiang S, Mani N, Wilson-Kubalek EM, Ku PI, Milligan RA, Subramanian R Developmental cell 31031197 Dev Cell 2019 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/31031197
Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A. Wijeratne S, Subramanian R eLife 30353849 Elife 2018 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/30353849
Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors. Lemma B, Mitchell NP, Subramanian R, Needleman DJ, Dogic Z Physical review. X 36643940 Phys Rev X 2022 Jul-Sep https://www.ncbi.nlm.nih.gov/pubmed/36643940
Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy. Mani N, Marchan MF, Subramanian R Journal of visualized experiments : JoVE 35253794 J Vis Exp 2022 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/35253794
Differential regulation of single microtubules and bundles by a three-protein module. Mani N, Jiang S, Neary AE, Wijeratne SS, Subramanian R Nature chemical biology 34083810 Nat Chem Biol 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34083810
Meeting report - Mitotic spindle: from living and synthetic systems to theory. Simunić J, Subramanian R Journal of cell science 31477579 J Cell Sci 2019 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/31477579
Motor guidance by long-range communication on the microtubule highway. Wijeratne SS, Fiorenza SA, Neary AE, Subramanian R, Betterton MD Proceedings of the National Academy of Sciences of the United States of America 35867749 Proc Natl Acad Sci U S A 2022 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/35867749
Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays. Wijeratne SS, Marchan MF, Tresback JS, Subramanian R Proceedings of the National Academy of Sciences of the United States of America 35101922 Proc Natl Acad Sci U S A 2022 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/35101922
Real-Time Visualization of Microtubule and Protofilament-Scale Dynamics in Multi-Microtubule Arrays by Atomic Force Microscopy. Wijeratne SS, Subramanian R Current protocols 37227098 Curr Protoc 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37227098
A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL Science advances 29507878 Sci Adv 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29507878
Resident risks. Spoto M, Oh J Nature microbiology 30046171 Nat Microbiol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30046171
Using genome-wide expression compendia to study microorganisms. Lee AJ, Reiter T, Doing G, Oh J, Hogan DA, Greene CS Computational and structural biotechnology journal 36016717 Comput Struct Biotechnol J 2022 https://www.ncbi.nlm.nih.gov/pubmed/36016717
Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults. Larson PJ, Zhou W, Santiago A, Driscoll S, Fleming E, Voigt AY, Chun OK, Grady JJ, Kuchel GA, Robison JT, Oh J Nature aging 36398033 Nat Aging 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/36398033
High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells. Deniz Derman I, Yeo M, Castaneda DC, Callender M, Horvath M, Mo Z, Xiong R, Fleming E, Chen P, Peeples ME, Palucka K, Oh J, Ozbolat IT Biofabrication 37536321 Biofabrication 2023 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/37536321
Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma. Voigt AY, Walter A, Young TH, Graham JP, Batista Bittencourt BM, de Mingo Pulido A, Prieto K, Tsai KY, Sundberg JP, Oh J Experimental dermatology 37350109 Exp Dermatol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37350109
Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin. Zhou W, Spoto M, Hardy R, Guan C, Fleming E, Larson PJ, Brown JS, Oh J Cell 32004459 Cell 2020 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/32004459
Recoding the metagenome: microbiome engineering in situ. Whitfill T, Oh J Current opinion in microbiology 31622928 Curr Opin Microbiol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31622928
Selective colonization ability of human fecal microbes in different mouse gut environments. Zhou W, Chow KH, Fleming E, Oh J The ISME journal 30442907 ISME J 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30442907
Strains to go: interactions of the skin microbiome beyond its species. Caldwell R, Zhou W, Oh J Current opinion in microbiology 36242896 Curr Opin Microbiol 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36242896
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Metagenomic growth rate inferences of strains in situ. Emiola A, Zhou W, Oh J Science advances 32494636 Sci Adv 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32494636
A host-microbiota interactome reveals extensive transkingdom connectivity. Sonnert ND, Rosen CE, Ghazi AR, Franzosa EA, Duncan-Lowey B, González-Hernández JA, Huck JD, Yang Y, Dai Y, Rice TA, Nguyen MT, Song D, Cao Y, Martin AL, Bielecka AA, Fischer S, Guan C, Oh J, Huttenhower C, Ring AM, Palm NW Nature 38509360 Nature 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38509360
BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome. Xiong R, Aiken E, Caldwell R, Vernon SD, Kozhaya L, Gunter C, Bateman L, Unutmaz D, Oh J bioRxiv : the preprint server for biology 38979186 bioRxiv 2025 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/38979186
Bioassay-Driven, Fractionation-Empowered, Focused Metabolomics for Discovering Bacterial Activators of Aryl Hydrocarbon Receptor. Tian H, Wang L, Hardy R, Kozhaya L, Placek L, Fleming E, Oh J, Unutmaz D, Yao X Journal of the American Society for Mass Spectrometry 38308645 J Am Soc Mass Spectrom 2024 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/38308645
Multi-'omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients. Xiong R, Gunter C, Fleming E, Vernon SD, Bateman L, Unutmaz D, Oh J Cell host & microbe 36758521 Cell Host Microbe 2023 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/36758521
Genotype-environment-driven dysbiosis in the skin microbiome of ichthyosis. Zhou W, Ring NG, Caldwell R, Milstone LM, Oh J The Journal of investigative dermatology 40571157 J Invest Dermatol 2025 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/40571157
Differential Hairless Mouse Strain-Specific Susceptibility to Skin Cancer and Sunburn. Voigt AY, Michaud M, Tsai KY, Oh J, Sundberg JP The Journal of investigative dermatology 30742806 J Invest Dermatol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/30742806
Challenges in Developing a Human Model System for Skin Microbiome Research. Larson PJ, Chong D, Fleming E, Oh J The Journal of investigative dermatology 32522484 J Invest Dermatol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32522484
Skin Microbiome Variation with Cancer Progression in Human Cutaneous Squamous Cell Carcinoma. Voigt AY, Emiola A, Johnson JS, Fleming ES, Nguyen H, Zhou W, Tsai KY, Fink C, Oh J The Journal of investigative dermatology 35390349 J Invest Dermatol 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35390349
State of Residency: Microbial Strain Diversity in the Skin. Kong HH, Oh J The Journal of investigative dermatology 34688614 J Invest Dermatol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/34688614
Cultivation of common bacterial species and strains from human skin, oral, and gut microbiota. Fleming E, Pabst V, Scholar Z, Xiong R, Voigt AY, Zhou W, Hoyt A, Hardy R, Peterson A, Beach R, Ondouah-Nzutchi Y, Dong J, Bateman L, Vernon SD, Oh J BMC microbiology 34649516 BMC Microbiol 2021 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/34649516
Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19. Landay A, Bartley J, Banerjee D, Hargis G, Haynes L, Keshavarzian A, Kuo CL, Kwon OS, Li S, Li S, Oh J, Ozbolat IT, Ucar D, Xu M, Yao X, Unutmaz D, Kuchel GA Frontiers in aging 35128530 Front Aging 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/35128530
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A Universal, Genomewide GuideFinder for CRISPR/Cas9 Targeting in Microbial Genomes. Spoto M, Guan C, Fleming E, Oh J mSphere 32051236 mSphere 2020 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/32051236
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Large-Scale CRISPRi and Transcriptomics of Staphylococcus epidermidis Identify Genetic Factors Implicated in Lifestyle Versatility. Spoto M, Riera Puma JP, Fleming E, Guan C, Ondouah Nzutchi Y, Kim D, Oh J mBio 36409086 mBio 2022 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/36409086
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Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2. Specht H, Emmott E, Petelski AA, Huffman RG, Perlman DH, Serra M, Kharchenko P, Koller A, Slavov N Genome biology 33504367 Genome Biol 2021 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/33504367
Voices of biotech research. Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett KS, Correia B, Dahlman J, de Oliveira T, Ertuerk A, Yanik MF, Henaff E, Huch M, Iliev ID, Jacobs T, Junca H, Keung A, Kolodkin-Gal I, Krishnaswamy S, Lancaster M, Macosko E, Martínez-Núñez MA, Miura K, Molloy J, Cruz AO, Platt RJ, Posey AD Jr, Shao H, Simunovic M, Slavov N, Takebe T, Vandenberghe LH, Varshney RK, Wang J Nature biotechnology 33692517 Nat Biotechnol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33692517
Ribosome Stoichiometry: From Form to Function. Emmott E, Jovanovic M, Slavov N Trends in biochemical sciences 30473427 Trends Biochem Sci 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30473427
SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation. Budnik B, Levy E, Harmange G, Slavov N Genome biology 30343672 Genome Biol 2018 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/30343672
Unpicking the proteome in single cells. Slavov N Science (New York, N.Y.) 32001644 Science 2020 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/32001644
New Views of Old Proteins: Clarifying the Enigmatic Proteome. Burnum-Johnson KE, Conrads TP, Drake RR, Herr AE, Iyengar R, Kelly RT, Lundberg E, MacCoss MJ, Naba A, Nolan GP, Pevzner PA, Rodland KD, Sechi S, Slavov N, Spraggins JM, Van Eyk JE, Vidal M, Vogel C, Walt DR, Kelleher NL Molecular & cellular proteomics : MCP 35654359 Mol Cell Proteomics 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35654359
Optimizing Accuracy and Depth of Protein Quantification in Experiments Using Isobaric Carriers. Specht H, Slavov N Journal of proteome research 33190502 J Proteome Res 2021 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/33190502
DO-MS: Data-Driven Optimization of Mass Spectrometry Methods. Huffman RG, Chen A, Specht H, Slavov N Journal of proteome research 31081635 J Proteome Res 2019 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/31081635
Exploring functional protein covariation across single cells using nPOP. Leduc A, Huffman RG, Cantlon J, Khan S, Slavov N Genome biology 36527135 Genome Biol 2022 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/36527135
Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments. Gatto L, Aebersold R, Cox J, Demichev V, Derks J, Emmott E, Franks AM, Ivanov AR, Kelly RT, Khoury L, Leduc A, MacCoss MJ, Nemes P, Perlman DH, Petelski AA, Rose CM, Schoof EM, Van Eyk J, Vanderaa C, Yates JR 3rd, Slavov N Nature methods 36864200 Nat Methods 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36864200
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide. Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A Journal of immunology (Baltimore, Md. : 1950) 28461567 J Immunol 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28461567
Integration of a multi-omics stem cell differentiation dataset using a dynamical model. van den Berg PR, Bérenger-Currias NMLP, Budnik B, Slavov N, Semrau S PLoS genetics 37167320 PLoS Genet 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37167320
Single cell protein analysis for systems biology. Levy E, Slavov N Essays in biochemistry 30072488 Essays Biochem 2018 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/30072488
Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics. Huffman RG, Leduc A, Wichmann C, Di Gioia M, Borriello F, Specht H, Derks J, Khan S, Khoury L, Emmott E, Petelski AA, Perlman DH, Cox J, Zanoni I, Slavov N Nature methods 37012480 Nat Methods 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37012480
Driving Single Cell Proteomics Forward with Innovation. Slavov N Journal of proteome research 34597050 J Proteome Res 2021 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/34597050
Increasing proteomics throughput. Slavov N Nature biotechnology 33767394 Nat Biotechnol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33767394
Analyzing Ribosome Remodeling in Health and Disease. Petelski AA, Slavov N Proteomics 32820594 Proteomics 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32820594
Post-transcriptional regulation across human tissues. Franks A, Airoldi E, Slavov N PLoS computational biology 28481885 PLoS Comput Biol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28481885
Single-cell protein analysis by mass spectrometry. Slavov N Current opinion in chemical biology 32599342 Curr Opin Chem Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/32599342
Transformative Opportunities for Single-Cell Proteomics. Specht H, Slavov N Journal of proteome research 29945450 J Proteome Res 2018 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/29945450
Voices in methods development. Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M, Zhuang X Nature methods 31562479 Nat Methods 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31562479
Multiplexed single-cell proteomics using SCoPE2. Petelski AA, Emmott E, Leduc A, Huffman RG, Specht H, Perlman DH, Slavov N Nature protocols 34716448 Nat Protoc 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34716448
DART-ID increases single-cell proteome coverage. Chen AT, Franks A, Slavov N PLoS computational biology 31260443 PLoS Comput Biol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31260443
Approaches for Studying Ribosome Specialization. Emmott E, Jovanovic M, Slavov N Trends in biochemical sciences 30792028 Trends Biochem Sci 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30792028
Increasing the throughput of sensitive proteomics by plexDIA. Derks J, Leduc A, Wallmann G, Huffman RG, Willetts M, Khan S, Specht H, Ralser M, Demichev V, Slavov N Nature biotechnology 35835881 Nat Biotechnol 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/35835881
Scaling Up Single-Cell Proteomics. Slavov N Molecular & cellular proteomics : MCP 34808355 Mol Cell Proteomics 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34808355
Measuring Protein Shapes in Living Cells. Slavov N Journal of proteome research 33988997 J Proteome Res 2021 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/33988997
Quantifying Homologous Proteins and Proteoforms. Malioutov D, Chen T, Airoldi E, Jaffe J, Budnik B, Slavov N Molecular & cellular proteomics : MCP 30282776 Mol Cell Proteomics 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30282776
Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex. Wang JY, Hoel CM, Al-Shayeb B, Banfield JF, Brohawn SG, Doudna JA Nature communications 33958590 Nat Commun 2021 May 6 https://www.ncbi.nlm.nih.gov/pubmed/33958590
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Gunasekar SK, Xie L, Kumar A, Hong J, Chheda PR, Kang C, Kern DM, My-Ta C, Maurer J, Heebink J, Gerber EE, Grzesik WJ, Elliot-Hudson M, Zhang Y, Key P, Kulkarni CA, Beals JW, Smith GI, Samuel I, Smith JK, Nau P, Imai Y, Sheldon RD, Taylor EB, Lerner DJ, Norris AW, Klein S, Brohawn SG, Kerns R, Sah R Nature communications 35145074 Nat Commun 2022 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/35145074
Author Correction: Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG Nature structural & molecular biology 34285420 Nat Struct Mol Biol 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34285420
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R eLife 31674909 Elife 2019 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/31674909
SARS-CoV-2 3a expression, purification, and reconstitution into lipid nanodiscs. Kern DM, Brohawn SG Methods in enzymology 34099172 Methods Enzymol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34099172
Structural basis for pH gating of the two-pore domain K(+) channel TASK2. Li B, Rietmeijer RA, Brohawn SG Nature 32999458 Nature 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32999458
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs. Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG bioRxiv : the preprint server for biology 32587976 bioRxiv 2021 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/32587976
Studying Mechanosensitivity of Two-Pore Domain K(+) Channels in Cellular and Reconstituted Proteoliposome Membranes. Del Mármol J, Rietmeijer RA, Brohawn SG Methods in molecular biology (Clifton, N.J.) 29058189 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29058189
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs. Kern DM, Oh S, Hite RK, Brohawn SG eLife 30775971 Elife 2019 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/30775971
Structural Basis for pH-gating of the K(+) channel TWIK1 at the selectivity filter. Turney TS, Li V, Brohawn SG Nature communications 35680900 Nat Commun 2022 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/35680900
Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs. Tucker K, Sridharan S, Adesnik H, Brohawn SG Nature communications 35977941 Nat Commun 2022 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/35977941
Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Hoel CM, Zhang L, Brohawn SG eLife 36373655 Elife 2022 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/36373655
Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Rietmeijer RA, Sorum B, Li B, Brohawn SG Neuron 34390650 Neuron 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34390650
Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization. Li B, Hoel CM, Brohawn SG Nature communications 34824283 Nat Commun 2021 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/34824283
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG Nature structural & molecular biology 34158638 Nat Struct Mol Biol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34158638
Ultrasound activates mechanosensitive TRAAK K(+) channels through the lipid membrane. Sorum B, Rietmeijer RA, Gopakumar K, Adesnik H, Brohawn SG Proceedings of the National Academy of Sciences of the United States of America 33542098 Proc Natl Acad Sci U S A 2021 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/33542098
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. Reid MS, Kern DM, Brohawn SG eLife 32286222 Elife 2020 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/32286222
Germline DNA replication timing shapes mammalian genome composition. Yehuda Y, Blumenfeld B, Mayorek N, Makedonski K, Vardi O, Cohen-Daniel L, Mansour Y, Baror-Sebban S, Masika H, Farago M, Berger M, Carmi S, Buganim Y, Koren A, Simon I Nucleic acids research 29986092 Nucleic Acids Res 2018 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/29986092
Cell-type specificity of the human mutation landscape with respect to DNA replication dynamics. Caballero M, Boos D, Koren A Cell genomics 37388911 Cell Genom 2023 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/37388911
Next-Generation Sequencing Enables Spatiotemporal Resolution of Human Centromere Replication Timing. Massey DJ, Kim D, Brooks KE, Smolka MB, Koren A Genes 30987063 Genes (Basel) 2019 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/30987063
Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility. Yaacov A, Vardi O, Blumenfeld B, Greenberg A, Massey DJ, Koren A, Adar S, Simon I, Rosenberg S Cancer research 34702725 Cancer Res 2021 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/34702725
The genetic architecture of DNA replication timing in human pluripotent stem cells. Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clark AG, Koren A Nature communications 34799581 Nat Commun 2021 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/34799581
Telomere-to-telomere human DNA replication timing profiles. Massey DJ, Koren A Scientific reports 35688856 Sci Rep 2022 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/35688856
Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation. Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A Human molecular genetics 35394024 Hum Mol Genet 2022 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/35394024
Mutation Rate Variability across Human Y-Chromosome Haplogroups. Ding Q, Hu Y, Koren A, Clark AG Molecular biology and evolution 33049047 Mol Biol Evol 2021 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/33049047
Germline Structural Variations Are Preferential Sites of DNA Replication Timing Plasticity during Development. Hulke ML, Siefert JC, Sansam CL, Koren A Genome biology and evolution 31076752 Genome Biol Evol 2019 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/31076752
TIGER: inferring DNA replication timing from whole-genome sequence data. Koren A, Massey DJ, Bracci AN Bioinformatics (Oxford, England) 33704387 Bioinformatics 2021 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/33704387
Positive and Negative Regulation of DNA Replication Initiation. Ding Q, Koren A Trends in genetics : TIG 32739030 Trends Genet 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32739030
Genomic methods for measuring DNA replication dynamics. Hulke ML, Massey DJ, Koren A Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 31848781 Chromosome Res 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31848781
Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Jones MJK, Gelot C, Munk S, Koren A, Kawasoe Y, George KA, Santos RE, Olsen JV, McCarroll SA, Frattini MG, Takahashi TS, Jallepalli PV Molecular cell 33545059 Mol Cell 2021 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/33545059
High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control. Massey DJ, Koren A Nature communications 35504890 Nat Commun 2022 May 3 https://www.ncbi.nlm.nih.gov/pubmed/35504890
Replication timing analysis in polyploid cells reveals Rif1 uses multiple mechanisms to promote underreplication in Drosophila. Das S, Caballero M, Kolesnikova T, Zhimulev I, Koren A, Nordman J Genetics 34740250 Genetics 2021 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/34740250
Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes. Rivas MA, Durmaz C, Kloetgen A, Chin CR, Chen Z, Bhinder B, Koren A, Viny AD, Scharer CD, Boss JM, Elemento O, Mason CE, Melnick AM Frontiers in immunology 34621263 Front Immunol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34621263
Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells. Deshpande M, Paniza T, Jalloul N, Nanjangud G, Twarowski J, Koren A, Zaninovic N, Zhan Q, Chadalavada K, Malkova A, Khiabanian H, Madireddy A, Rosenwaks Z, Gerhardt J Molecular cell 36099913 Mol Cell 2022 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/36099913
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer. Webster ALH, Sanders MA, Patel K, Dietrich R, Noonan RJ, Lach FP, White RR, Goldfarb A, Hadi K, Edwards MM, Donovan FX, Hoogenboezem RM, Jung M, Sridhar S, Wiley TF, Fedrigo O, Tian H, Rosiene J, Heineman T, Kennedy JA, Bean L, Rosti RO, Tryon R, Gonzalez AM, Rosenberg A, Luo JD, Carroll TS, Shroff S, Beaumont M, Velleuer E, Rastatter JC, Wells SI, Surrallés J, Bagby G, MacMillan ML, Wagner JE, Cancio M, Boulad F, Scognamiglio T, Vaughan R, Beaumont KG, Koren A, Imielinski M, Chandrasekharappa SC, Auerbach AD, Singh B, Kutler DI, Campbell PJ, Smogorzewska A Nature 36450981 Nature 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36450981
Replication timing alterations in leukemia affect clinically relevant chromosome domains. Rivera-Mulia JC, Sasaki T, Trevilla-Garcia C, Nakamichi N, Knapp DJHF, Hammond CA, Chang BH, Tyner JW, Devidas M, Zimmerman J, Klein KN, Somasundaram V, Druker BJ, Gruber TA, Koren A, Eaves CJ, Gilbert DM Blood advances 31698451 Blood Adv 2019 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/31698451
The landscape of somatic mutations in lymphoblastoid cell lines. Caballero M, Koren A Cell genomics 37388907 Cell Genom 2023 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/37388907
Chromosome Translocation Inflates Bacillus Forespores and Impacts Cellular Morphology. Lopez-Garrido J, Ojkic N, Khanna K, Wagner FR, Villa E, Endres RG, Pogliano K Cell 29425492 Cell 2018 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/29425492
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Lu S, Ye Q, Singh D, Cao Y, Diedrich JK, Yates JR 3rd, Villa E, Cleveland DW, Corbett KD Nature communications 33479198 Nat Commun 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/33479198
Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Akey CW, Singh D, Ouch C, Echeverria I, Nudelman I, Varberg JM, Yu Z, Fang F, Shi Y, Wang J, Salzberg D, Song K, Xu C, Gumbart JC, Suslov S, Unruh J, Jaspersen SL, Chait BT, Sali A, Fernandez-Martinez J, Ludtke SJ, Villa E, Rout MP Cell 34982960 Cell 2022 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/34982960
Preparing samples from whole cells using focused-ion-beam milling for cryo-electron tomography. Wagner FR, Watanabe R, Schampers R, Singh D, Persoon H, Schaffer M, Fruhstorfer P, Plitzko J, Villa E Nature protocols 32405053 Nat Protoc 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32405053
The In Situ Structure of Parkinson's Disease-Linked LRRK2. Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Lu TW, Boassa D, Taylor S, Villa E Cell 32783917 Cell 2020 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/32783917
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Yu H, Lu S, Gasior K, Singh D, Vazquez-Sanchez S, Tapia O, Toprani D, Beccari MS, Yates JR 3rd, Da Cruz S, Newby JM, Lafarga M, Gladfelter AS, Villa E, Cleveland DW Science (New York, N.Y.) 33335017 Science 2021 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/33335017
ExoSloNano: Multi-Modal Nanogold Tags for identification of Macromolecules in Live Cells & Cryo-Electron Tomograms. Young LN, Sherrard A, Zhou H, Shaikh F, Hutchings J, Riggi M, Rosen MK, Giraldez AJ, Villa E bioRxiv : the preprint server for biology 39416124 bioRxiv 2024 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/39416124
The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Lu S, Ye Q, Singh D, Villa E, Cleveland DW, Corbett KD bioRxiv : the preprint server for biology 32766587 bioRxiv 2020 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/32766587
Shaping an Endospore: Architectural Transformations During Bacillus subtilis Sporulation. Khanna K, Lopez-Garrido J, Pogliano K Annual review of microbiology 32660383 Annu Rev Microbiol 2020 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/32660383
Practical Approaches for Cryo-FIB Milling and Applications for Cellular Cryo-Electron Tomography. Lam V, Villa E Methods in molecular biology (Clifton, N.J.) 33367999 Methods Mol Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33367999
Assembly of a nucleus-like structure during viral replication in bacteria. Chaikeeratisak V, Nguyen K, Khanna K, Brilot AF, Erb ML, Coker JK, Vavilina A, Newton GL, Buschauer R, Pogliano K, Villa E, Agard DA, Pogliano J Science (New York, N.Y.) 28082593 Science 2017 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/28082593
The molecular architecture of engulfment during Bacillus subtilis sporulation. Khanna K, Lopez-Garrido J, Zhao Z, Watanabe R, Yuan Y, Sugie J, Pogliano K, Villa E eLife 31282858 Elife 2019 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/31282858
Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria. Chaikeeratisak V, Khanna K, Nguyen KT, Sugie J, Egan ME, Erb ML, Vavilina A, Nonejuie P, Nieweglowska E, Pogliano K, Agard DA, Villa E, Pogliano J Cell 31199917 Cell 2019 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/31199917
Generating Chromosome Geometries in a Minimal Cell From Cryo-Electron Tomograms and Chromosome Conformation Capture Maps. Gilbert BR, Thornburg ZR, Lam V, Rashid FM, Glass JI, Villa E, Dame RT, Luthey-Schulten Z Frontiers in molecular biosciences 34368224 Front Mol Biosci 2021 https://www.ncbi.nlm.nih.gov/pubmed/34368224
Challenges of Integrating Stochastic Dynamics and Cryo-Electron Tomograms in Whole-Cell Simulations. Earnest TM, Watanabe R, Stone JE, Mahamid J, Baumeister W, Villa E, Luthey-Schulten Z The journal of physical chemistry. B 28291359 J Phys Chem B 2017 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/28291359
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE Nature 32814344 Nature 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32814344
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems. Lasker K, Boeynaems S, Lam V, Scholl D, Stainton E, Briner A, Jacquemyn M, Daelemans D, Deniz A, Villa E, Holehouse AS, Gitler AD, Shapiro L Nature communications 36163138 Nat Commun 2022 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/36163138
Entropy-regularized deconvolution of cellular cryotransmission electron tomograms. Croxford M, Elbaum M, Arigovindan M, Kam Z, Agard D, Villa E, Sedat J Proceedings of the National Academy of Sciences of the United States of America 34876518 Proc Natl Acad Sci U S A 2021 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/34876518
How TPX2 helps microtubules branch out. Alfaro-Aco R, Petry S Cell cycle (Georgetown, Tex.) 28767311 Cell Cycle 2017 https://www.ncbi.nlm.nih.gov/pubmed/28767311
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A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches. Setru SU, Gouveia B, Alfaro-Aco R, Shaevitz JW, Stone HA, Petry S Nature physics 35211183 Nat Phys 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/35211183
Microtubule nucleation for spindle assembly: one molecule at a time. Kraus J, Alfaro-Aco R, Gouveia B, Petry S Trends in biochemical sciences 37482516 Trends Biochem Sci 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37482516
Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes in Xenopus laevis egg extract. Gouveia B, Setru SU, King MR, Hamlin A, Stone HA, Shaevitz JW, Petry S Nature communications 37344488 Nat Commun 2023 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/37344488
Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules. Song JG, King MR, Zhang R, Kadzik RS, Thawani A, Petry S The Journal of cell biology 29875259 J Cell Biol 2018 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/29875259
Mechanisms of Mitotic Spindle Assembly. Petry S Annual review of biochemistry 27145846 Annu Rev Biochem 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27145846
The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy. Thawani A, Rale MJ, Coudray N, Bhabha G, Stone HA, Shaevitz JW, Petry S eLife 32538784 Elife 2020 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/32538784
Structural analysis of the role of TPX2 in branching microtubule nucleation. Alfaro-Aco R, Thawani A, Petry S The Journal of cell biology 28264915 J Cell Biol 2017 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/28264915
Phase Transitioning the Centrosome into a Microtubule Nucleator. Rale MJ, Kadzik RS, Petry S Biochemistry 29256606 Biochemistry 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29256606
Biochemical reconstitution of branching microtubule nucleation. Alfaro-Aco R, Thawani A, Petry S eLife 31933480 Elife 2020 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/31933480
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Structural basis of protein condensation on microtubules underlying branching microtubule nucleation. Guo C, Alfaro-Aco R, Zhang C, Russell RW, Petry S, Polenova T Nature communications 37344496 Nat Commun 2023 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/37344496
Molecular insight into how γ-TuRC makes microtubules. Thawani A, Petry S Journal of cell science 34297125 J Cell Sci 2021 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/34297125
How Microtubules Build the Spindle Branch by Branch. Travis SM, Mahon BP, Petry S Annual review of cell and developmental biology 35759800 Annu Rev Cell Dev Biol 2022 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/35759800
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Dissecting Protein Complexes in Branching Microtubule Nucleation Using Meiotic Xenopus Egg Extracts. Song JG, Petry S Cold Spring Harbor protocols 29321281 Cold Spring Harb Protoc 2018 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/29321281
Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation. King MR, Petry S Nature communications 31937751 Nat Commun 2020 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/31937751
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The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC). Rale MJ, Romer B, Mahon BP, Travis SM, Petry S eLife 36515268 Elife 2022 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/36515268
Allosteric modulation of protein-protein interactions by individual lipid binding events. Cong X, Liu Y, Liu W, Liang X, Laganowsky A Nature communications 29259178 Nat Commun 2017 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/29259178
Allostery revealed within lipid binding events to membrane proteins. Patrick JW, Boone CD, Liu W, Conover GM, Liu Y, Cong X, Laganowsky A Proceedings of the National Academy of Sciences of the United States of America 29507234 Proc Natl Acad Sci U S A 2018 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/29507234
Variable-Temperature Native Mass Spectrometry for Studies of Protein Folding, Stabilities, Assembly, and Molecular Interactions. Laganowsky A, Clemmer DE, Russell DH Annual review of biophysics 34932911 Annu Rev Biophys 2022 May 9 https://www.ncbi.nlm.nih.gov/pubmed/34932911
Native IM-Orbitrap MS: Resolving What Was Hidden. Poltash ML, McCabe JW, Shirzadeh M, Laganowsky A, Russell DH Trends in analytical chemistry : TRAC 32189816 Trends Analyt Chem 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32189816
Structural basis for lipid and copper regulation of the ABC transporter MsbA. Lyu J, Liu C, Zhang T, Schrecke S, Elam NP, Packianathan C, Hochberg GKA, Russell D, Zhao M, Laganowsky A Nature communications 36435815 Nat Commun 2022 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/36435815
Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions. Lyu J, Zhang T, Marty MT, Clemmer D, Russell DH, Laganowsky A bioRxiv : the preprint server for biology 37461710 bioRxiv 2023 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/37461710
Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry. Sipe SN, Patrick JW, Laganowsky A, Brodbelt JS Analytical chemistry 31765130 Anal Chem 2020 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/31765130
Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel. Liu Y, LoCaste CE, Liu W, Poltash ML, Russell DH, Laganowsky A Nature communications 30902995 Nat Commun 2019 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/30902995
Generation of Charge-Reduced Ions of Membrane Protein Complexes for Native Ion Mobility Mass Spectrometry Studies. Patrick JW, Laganowsky A Journal of the American Society for Mass Spectrometry 30887461 J Am Soc Mass Spectrom 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30887461
Small molecule peptidomimetic trypsin inhibitors: validation of an EKO binding mode, but with a twist. Lyu RL, Joy S, Packianathan C, Laganowsky A, Burgess K Organic & biomolecular chemistry 35225309 Org Biomol Chem 2022 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/35225309
Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions. Zhu Y, Schrecke S, Tang S, Odenkirk MT, Walker T, Stover L, Lyu J, Zhang T, Russell D, Baker ES, Yan X, Laganowsky A Journal of the American Chemical Society 35421309 J Am Chem Soc 2022 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/35421309
Development of Native MS Capabilities on an Extended Mass Range Q-TOF MS. Mallis CS, Zheng X, Qiu X, McCabe JW, Shirzadeh M, Lyu J, Laganowsky A, Russell DH International journal of mass spectrometry 33162786 Int J Mass Spectrom 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33162786
Variable-Temperature Electrospray Ionization for Temperature-Dependent Folding/Refolding Reactions of Proteins and Ligand Binding. McCabe JW, Shirzadeh M, Walker TE, Lin CW, Jones BJ, Wysocki VH, Barondeau DP, Clemmer DE, Laganowsky A, Russell DH Analytical chemistry 33904705 Anal Chem 2021 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33904705
Selective regulation of human TRAAK channels by biologically active phospholipids. Schrecke S, Zhu Y, McCabe JW, Bartz M, Packianathan C, Zhao M, Zhou M, Russell D, Laganowsky A Nature chemical biology 32989299 Nat Chem Biol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32989299
THE IMS PARADOX: A PERSPECTIVE ON STRUCTURAL ION MOBILITY-MASS SPECTROMETRY. McCabe JW, Hebert MJ, Shirzadeh M, Mallis CS, Denton JK, Walker TE, Russell DH Mass spectrometry reviews 32608033 Mass Spectrom Rev 2021 May https://www.ncbi.nlm.nih.gov/pubmed/32608033
Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies. Lyu J, Liu Y, McCabe JW, Schrecke S, Fang L, Russell DH, Laganowsky A Analytical chemistry 32672445 Anal Chem 2020 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/32672445
Surface induced dissociation as a tool to study membrane protein complexes. Harvey SR, Liu Y, Liu W, Wysocki VH, Laganowsky A Chemical communications (Cambridge, England) 28243658 Chem Commun (Camb) 2017 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/28243658
Development and Evaluation of a Reverse-Entry Ion Source Orbitrap Mass Spectrometer. Poltash ML, McCabe JW, Patrick JW, Laganowsky A, Russell DH Journal of the American Society for Mass Spectrometry 29796735 J Am Soc Mass Spectrom 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/29796735
Fourier Transform-Ion Mobility-Orbitrap Mass Spectrometer: A Next-Generation Instrument for Native Mass Spectrometry. Poltash ML, McCabe JW, Shirzadeh M, Laganowsky A, Clowers BH, Russell DH Analytical chemistry 30091588 Anal Chem 2018 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/30091588
Topological Analysis of Transthyretin Disassembly Mechanism: Surface-Induced Dissociation Reveals Hidden Reaction Pathways. Shirzadeh M, Boone CD, Laganowsky A, Russell DH Analytical chemistry 30642177 Anal Chem 2019 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/30642177
Variable-Temperature ESI-IMS-MS Analysis of Myohemerythrin Reveals Ligand Losses, Unfolding, and a Non-Native Disulfide Bond. Woodall DW, El-Baba TJ, Fuller DR, Liu W, Brown CJ, Laganowsky A, Russell DH, Clemmer DE Analytical chemistry 31038926 Anal Chem 2019 May 21 https://www.ncbi.nlm.nih.gov/pubmed/31038926
Insight into the Phospholipid-Binding Preferences of Kir3.4. Qiao P, Schrecke S, Lyu J, Zhu Y, Zhang T, Benavides A, Laganowsky A Biochemistry 34846128 Biochemistry 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34846128
Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions. Qiao P, Schrecke S, Walker T, McCabe JW, Lyu J, Zhu Y, Zhang T, Kumar S, Clemmer D, Russell DH, Laganowsky A The journal of physical chemistry letters 34928154 J Phys Chem Lett 2021 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/34928154
Implementing Digital-Waveform Technology for Extended m/z Range Operation on a Native Dual-Quadrupole FT-IM-Orbitrap Mass Spectrometer. McCabe JW, Jones BJ, Walker TE, Schrader RL, Huntley AP, Lyu J, Hoffman NM, Anderson GA, Reilly PTA, Laganowsky A, Wysocki VH, Russell DH Journal of the American Society for Mass Spectrometry 34797072 J Am Soc Mass Spectrom 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/34797072
Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry. Moghadamchargari Z, Huddleston J, Shirzadeh M, Zheng X, Clemmer DE, M Raushel F, Russell DH, Laganowsky A Biochemistry 31306575 Biochemistry 2019 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/31306575
First-Principles Collision Cross Section Measurements of Large Proteins and Protein Complexes. McCabe JW, Mallis CS, Kocurek KI, Poltash ML, Shirzadeh M, Hebert MJ, Fan L, Walker TE, Zheng X, Jiang T, Dong S, Lin CW, Laganowsky A, Russell DH Analytical chemistry 32662991 Anal Chem 2020 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/32662991
A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Khan D, Lee D, Gulten G, Aggarwal A, Wofford J, Krieger I, Tripathi A, Patrick JW, Eckert DM, Laganowsky A, Sacchettini J, Lindahl P, Bankaitis VA eLife 32780017 Elife 2020 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/32780017
Evidence for Many Unique Solution Structures for Chymotrypsin Inhibitor 2: A Thermodynamic Perspective Derived from vT-ESI-IMS-MS Measurements. Raab SA, El-Baba TJ, Woodall DW, Liu W, Liu Y, Baird Z, Hales DA, Laganowsky A, Russell DH, Clemmer DE Journal of the American Chemical Society 32866376 J Am Chem Soc 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/32866376
Investigation of Protein-Lipid Interactions Using Native Mass Spectrometry. Cong X, Patrick JW, Liu Y, Liang X, Liu W, Laganowsky A Methods in molecular biology (Clifton, N.J.) 34718990 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/34718990
Protons Are Fast and Smart; Proteins Are Slow and Dumb: On the Relationship of Electrospray Ionization Charge States and Conformations. Raab SA, El-Baba TJ, Laganowsky A, Russell DH, Valentine SJ, Clemmer DE Journal of the American Society for Mass Spectrometry 34151568 J Am Soc Mass Spectrom 2021 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/34151568
Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J Proceedings of the National Academy of Sciences of the United States of America 29279396 Proc Natl Acad Sci U S A 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29279396
Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants. Moghadamchargari Z, Shirzadeh M, Liu C, Schrecke S, Packianathan C, Russell DH, Zhao M, Laganowsky A Proceedings of the National Academy of Sciences of the United States of America 33723061 Proc Natl Acad Sci U S A 2021 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/33723061
Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions. Lyu J, Zhang T, Marty MT, Clemmer D, Russell DH, Laganowsky A eLife 38252560 Elife 2024 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/38252560
GenomeDISCO: a concordance score for chromosome conformation capture experiments using random walks on contact map graphs. Ursu O, Boley N, Taranova M, Wang YXR, Yardimci GG, Stafford Noble W, Kundaje A Bioinformatics (Oxford, England) 29554289 Bioinformatics 2018 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/29554289
Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis. Liu X, Sun T, Shcherbina A, Li Q, Jarmoskaite I, Kappel K, Ramaswami G, Das R, Kundaje A, Li JB Nature communications 33846332 Nat Commun 2021 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/33846332
NETWORK MODELLING OF TOPOLOGICAL DOMAINS USING HI-C DATA. Wang YXR, Sarkar P, Ursu O, Kundaje A, Bickel PJ The annals of applied statistics 32968472 Ann Appl Stat 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/32968472
Opportunities and challenges for transcriptome-wide association studies. Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A Nature genetics 30926968 Nat Genet 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30926968
Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts. Nair S, Kim DS, Perricone J, Kundaje A Bioinformatics (Oxford, England) 31510655 Bioinformatics 2019 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/31510655
Denoising genome-wide histone ChIP-seq with convolutional neural networks. Koh PW, Pierson E, Kundaje A Bioinformatics (Oxford, England) 28881977 Bioinformatics 2017 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/28881977
Opportunities and obstacles for deep learning in biology and medicine. Ching T, Himmelstein DS, Beaulieu-Jones BK, Kalinin AA, Do BT, Way GP, Ferrero E, Agapow PM, Zietz M, Hoffman MM, Xie W, Rosen GL, Lengerich BJ, Israeli J, Lanchantin J, Woloszynek S, Carpenter AE, Shrikumar A, Xu J, Cofer EM, Lavender CA, Turaga SC, Alexandari AM, Lu Z, Harris DJ, DeCaprio D, Qi Y, Kundaje A, Peng Y, Wiley LK, Segler MHS, Boca SM, Swamidass SJ, Huang A, Gitter A, Greene CS Journal of the Royal Society, Interface 29618526 J R Soc Interface 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29618526
GkmExplain: fast and accurate interpretation of nonlinear gapped k-mer SVMs. Shrikumar A, Prakash E, Kundaje A Bioinformatics (Oxford, England) 31510661 Bioinformatics 2019 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/31510661
Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin. Yang D, Denny SK, Greenside PG, Chaikovsky AC, Brady JJ, Ouadah Y, Granja JM, Jahchan NS, Lim JS, Kwok S, Kong CS, Berghoff AS, Schmitt A, Reinhardt HC, Park KS, Preusser M, Kundaje A, Greenleaf WJ, Sage J, Winslow MM Cancer discovery 30228179 Cancer Discov 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30228179
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation. Kim DS, Risca VI, Reynolds DL, Chappell J, Rubin AJ, Jung N, Donohue LKH, Lopez-Pajares V, Kathiria A, Shi M, Zhao Z, Deep H, Sharmin M, Rao D, Lin S, Chang HY, Snyder MP, Greenleaf WJ, Kundaje A, Khavari PA Nature genetics 34650237 Nat Genet 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34650237
Base-resolution models of transcription-factor binding reveal soft motif syntax. Avsec Ž, Weilert M, Shrikumar A, Krueger S, Alexandari A, Dalal K, Fropf R, McAnany C, Gagneur J, Kundaje A, Zeitlinger J Nature genetics 33603233 Nat Genet 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33603233
Prediction of protein-ligand interactions from paired protein sequence motifs and ligand substructures. Greenside P, Hillenmeyer M, Kundaje A Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 29218866 Pac Symp Biocomput 2018 https://www.ncbi.nlm.nih.gov/pubmed/29218866
Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells Primed for Differentiation. Shcherbina A, Li J, Narayanan C, Greenleaf W, Kundaje A, Chetty S Stem cells (Dayton, Ohio) 31135093 Stem Cells 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31135093
Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study. Wainberg M, Mahajan A, Kundaje A, McCarthy MI, Ingelsson E, Sinnott-Armstrong N, Rivas MA PLoS medicine 31821322 PLoS Med 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31821322
ChIP-ping the branches of the tree: functional genomics and the evolution of eukaryotic gene regulation. Marinov GK, Kundaje A Briefings in functional genomics 29529131 Brief Funct Genomics 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29529131
Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays. Movva R, Greenside P, Marinov GK, Nair S, Shrikumar A, Kundaje A PloS one 31206543 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/31206543
MTSplice predicts effects of genetic variants on tissue-specific splicing. Cheng J, Çelik MH, Kundaje A, Gagneur J Genome biology 33789710 Genome Biol 2021 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/33789710
Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum. Marinov GK, Trevino AE, Xiang T, Kundaje A, Grossman AR, Greenleaf WJ Nature genetics 33927397 Nat Genet 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33927397
Accelerating in silico saturation mutagenesis using compressed sensing. Schreiber J, Nair S, Balsubramani A, Kundaje A Bioinformatics (Oxford, England) 35678521 Bioinformatics 2022 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/35678521
Discovering epistatic feature interactions from neural network models of regulatory DNA sequences. Greenside P, Shimko T, Fordyce P, Kundaje A Bioinformatics (Oxford, England) 30423062 Bioinformatics 2018 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/30423062
The Kipoi repository accelerates community exchange and reuse of predictive models for genomics. Avsec Ž, Kreuzhuber R, Israeli J, Xu N, Cheng J, Shrikumar A, Banerjee A, Kim DS, Beier T, Urban L, Kundaje A, Stegle O, Gagneur J Nature biotechnology 31138913 Nat Biotechnol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31138913
fastISM: performant in silico saturation mutagenesis for convolutional neural networks. Nair S, Shrikumar A, Schreiber J, Kundaje A Bioinformatics (Oxford, England) 35238376 Bioinformatics 2022 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/35238376
Domain-adaptive neural networks improve cross-species prediction of transcription factor binding. Cochran K, Srivastava D, Shrikumar A, Balsubramani A, Hardison RC, Kundaje A, Mahony S Genome research 35042722 Genome Res 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35042722
Transparency and reproducibility in artificial intelligence. Haibe-Kains B, Adam GA, Hosny A, Khodakarami F, Massive Analysis Quality Control (MAQC) Society Board of Directors, Waldron L, Wang B, McIntosh C, Goldenberg A, Kundaje A, Greene CS, Broderick T, Hoffman MM, Leek JT, Korthauer K, Huber W, Brazma A, Pineau J, Tibshirani R, Hastie T, Ioannidis JPA, Quackenbush J, Aerts HJWL Nature 33057217 Nature 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33057217
The chromatin landscape of the euryarchaeon Haloferax volcanii. Marinov GK, Bagdatli ST, Wu T, He C, Kundaje A, Greenleaf WJ Genome biology 37932847 Genome Biol 2023 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/37932847
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease. Ameen M, Sundaram L, Shen M, Banerjee A, Kundu S, Nair S, Shcherbina A, Gu M, Wilson KD, Varadarajan A, Vadgama N, Balsubramani A, Wu JC, Engreitz JM, Farh K, Karakikes I, Wang KC, Quertermous T, Greenleaf WJ, Kundaje A Cell 36563664 Cell 2022 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/36563664
Epigenetic fates of gene silencing established by heterochromatin spreading in cell identity and genome stability. Greenstein RA, Al-Sady B Current genetics 30390097 Curr Genet 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30390097
Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading. Kennedy DR, Lemiere J, Tan C, Simental E, Braxton J, Maxwell RA, Amine AA, Al-Sady B bioRxiv : the preprint server for biology 39554105 bioRxiv 2024 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/39554105
Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability. Greenstein RA, Jones SK, Spivey EC, Rybarski JR, Finkelstein IJ, Al-Sady B eLife 30020075 Elife 2018 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/30020075
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states. Murawska M, Greenstein RA, Schauer T, Olsen KCF, Ng H, Ladurner AG, Al-Sady B, Braun S Cell reports 34731638 Cell Rep 2021 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/34731638
Heterodimerization of H3K9 histone methyltransferases G9a and GLP activates methyl reading and writing capabilities. Sanchez NA, Kallweit LM, Trnka MJ, Clemmer CL, Al-Sady B The Journal of biological chemistry 34619147 J Biol Chem 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34619147
Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction. Greenstein RA, Ng H, Barrales RR, Tan C, Braun S, Al-Sady B PLoS genetics 35584134 PLoS Genet 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35584134
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability. Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B Genes & development 31805521 Genes Dev 2020 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/31805521
Assembly and structure of the SSU processome-a nucleolar precursor of the small ribosomal subunit. Barandun J, Hunziker M, Klinge S Current opinion in structural biology 29414516 Curr Opin Struct Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29414516
The complete structure of the small-subunit processome. Barandun J, Chaker-Margot M, Hunziker M, Molloy KR, Chait BT, Klinge S Nature structural & molecular biology 28945246 Nat Struct Mol Biol 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28945246
Assembly and early maturation of large subunit precursors. Chaker-Margot M, Klinge S RNA (New York, N.Y.) 30670483 RNA 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30670483
Conformational switches control early maturation of the eukaryotic small ribosomal subunit. Hunziker M, Barandun J, Buzovetsky O, Steckler C, Molina H, Klinge S eLife 31206356 Elife 2019 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/31206356
Ribosome assembly coming into focus. Klinge S, Woolford JL Jr Nature reviews. Molecular cell biology 30467428 Nat Rev Mol Cell Biol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30467428
Nucleolar maturation of the human small subunit processome. Singh S, Vanden Broeck A, Miller L, Chaker-Margot M, Klinge S Science (New York, N.Y.) 34516797 Science 2021 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/34516797
Modular assembly of the nucleolar pre-60S ribosomal subunit. Sanghai ZA, Miller L, Molloy KR, Barandun J, Hunziker M, Chaker-Margot M, Wang J, Chait BT, Klinge S Nature 29512650 Nature 2018 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/29512650
Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome. Barandun J, Hunziker M, Vossbrinck CR, Klinge S Nature microbiology 31332387 Nat Microbiol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31332387
Machine Learning Establishes Single-Cell Calcium Dynamics as an Early Indicator of Antibiotic Response. Meyer CT, Jewell MP, Miller EJ, Kralj JM Microorganisms 34063175 Microorganisms 2021 May 5 https://www.ncbi.nlm.nih.gov/pubmed/34063175
Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides. Bruni GN, Kralj JM eLife 32748785 Elife 2020 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/32748785
A high-throughput and low-waste viability assay for microbes. Meyer CT, Lynch GK, Stamo DF, Miller EJ, Chatterjee A, Kralj JM Nature microbiology 37919425 Nat Microbiol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37919425
High Throughput Viability Assay for Microbiology. Meyer CT, Lynch GK, Stamo DF, Miller EJ, Chatterjee A, Kralj JM bioRxiv : the preprint server for biology 36712102 bioRxiv 2023 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/36712102
Genome-Wide Functional Screen for Calcium Transients in Escherichia coli Identifies Increased Membrane Potential Adaptation to Persistent DNA Damage. Luder R, Bruni GN, Kralj JM Journal of bacteriology 33199283 J Bacteriol 2021 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/33199283
Voltage-gated calcium flux mediates Escherichia coli mechanosensation. Bruni GN, Weekley RA, Dodd BJT, Kralj JM Proceedings of the National Academy of Sciences of the United States of America 28808010 Proc Natl Acad Sci U S A 2017 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/28808010
Live Cell Imaging Reveals pH Oscillations in Saccharomyces cerevisiae During Metabolic Transitions. Dodd BJT, Kralj JM Scientific reports 29066766 Sci Rep 2017 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/29066766
Finding the Spark. Kralj JM Bioelectricity 34476390 Bioelectricity 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/34476390
Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds. Verbanic S, Shen Y, Lee J, Deacon JM, Chen IA NPJ biofilms and microbiomes 32358500 NPJ Biofilms Microbiomes 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32358500
PacBio sequencing output increased through uniform and directional fivefold concatenation. Kanwar N, Blanco C, Chen IA, Seelig B Scientific reports 34508117 Sci Rep 2021 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/34508117
Rapid Colorimetric Detection of Bacterial Species through the Capture of Gold Nanoparticles by Chimeric Phages. Peng H, Chen IA ACS nano 30586498 ACS Nano 2019 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/30586498
Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes. Janzen E, Shen Y, Vázquez-Salazar A, Liu Z, Blanco C, Kenchel J, Chen IA Nature communications 35752631 Nat Commun 2022 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/35752631
Effects of Preservation and Propagation Methodology on Microcosms Derived from the Oral Microbiome. Zhou B, Mobberley J, Shi K, Chen IA Microorganisms 36363738 Microorganisms 2022 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/36363738
Biosourced Functional Hydroxybenzoate-co-Lactide Polymers with Antimicrobial Activity. Salas-Ambrosio P, Vexler S, P Sivasankaran R, Vlahakis N, Lai RS, Johnson C, Baas-Maynard SI, Min DS, Lower H, Doyle AG, Tang Y, Rodriguez JA, Chen IA, Read de Alaniz J, Maynard HD Journal of the American Chemical Society 40380948 J Am Chem Soc 2025 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/40380948
Phage therapy administered noninvasively could be effective in thin tubes subject to episodic flow despite washout: a simulation study. Blanco C, Chen IA Physical biology 31266001 Phys Biol 2019 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/31266001
Modulation of α-Synuclein Aggregation In Vitro by a DNA Aptamer. Tran CH, Saha R, Blanco C, Bagchi D, Chen IA Biochemistry 35994742 Biochemistry 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/35994742
Vesicle encapsulation stabilizes intermolecular association and structure formation of functional RNA and DNA. Peng H, Lelievre A, Landenfeld K, Müller S, Chen IA Current biology : CB 34762821 Curr Biol 2022 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/34762821
A Bayesian nonparametric analysis for zero-inflated multivariate count data with application to microbiome study. Shuler K, Verbanic S, Chen IA, Lee J Journal of the Royal Statistical Society. Series C, Applied statistics 37440868 J R Stat Soc Ser C Appl Stat 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/37440868
Preparation of Bioconjugates of Chimeric M13 Phage and Gold Nanorods. Peng H, Chen IA Methods in molecular biology (Clifton, N.J.) 38526728 Methods Mol Biol 2024 https://www.ncbi.nlm.nih.gov/pubmed/38526728
Visualization of Engineered M13 Phages Bound to Bacterial Targets by Transmission Electron Microscopy. Yang Y, Chen IA Methods in molecular biology (Clifton, N.J.) 38526731 Methods Mol Biol 2024 https://www.ncbi.nlm.nih.gov/pubmed/38526731
High throughput sequencing of in vitro selections of mRNA-displayed peptides: data analysis and applications. Blanco C , Verbanic S , Seelig B , Chen IA Physical chemistry chemical physics : PCCP 31967131 Phys Chem Chem Phys 2020 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/31967131
Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy. Kang D, Bagchi D, Chen IA Advanced therapeutics 38933919 Adv Ther (Weinh) 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38933919
Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution. Janzen E, Blanco C, Peng H, Kenchel J, Chen IA Chemical reviews 32011135 Chem Rev 2020 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/32011135
The Chronic Wound Phageome: Phage Diversity and Associations with Wounds and Healing Outcomes. Verbanic S, Deacon JM, Chen IA Microbiology spectrum 35435739 Microbiol Spectr 2022 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/35435739
Self-cleaving ribozymes: substrate specificity and synthetic biology applications. Peng H, Latifi B, Müller S, Lupták A, Chen IA RSC chemical biology 34704043 RSC Chem Biol 2021 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/34704043
Kinetic sequencing (k-Seq) as a massively parallel assay for ribozyme kinetics: utility and critical parameters. Shen Y, Pressman A, Janzen E, Chen IA Nucleic acids research 33772580 Nucleic Acids Res 2021 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/33772580
Chimeric Phage Nanoparticles for Rapid Characterization of Bacterial Pathogens: Detection in Complex Biological Samples and Determination of Antibiotic Sensitivity. Peng H, Borg RE, Nguyen ABN, Chen IA ACS sensors 32314570 ACS Sens 2020 May 22 https://www.ncbi.nlm.nih.gov/pubmed/32314570
EasyDIVER: A Pipeline for Assembling and Counting High-Throughput Sequencing Data from In Vitro Evolution of Nucleic Acids or Peptides. Blanco C, Verbanic S, Seelig B, Chen IA Journal of molecular evolution 32529275 J Mol Evol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32529275
Treatment of Wound Infections in a Mouse Model Using Zn(2+)-Releasing Phage Bound to Gold Nanorods. Peng H, Rossetto D, Mansy SS, Jordan MC, Roos KP, Chen IA ACS nano 35239330 ACS Nano 2022 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/35239330
Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. Verbanic S, Kim CY, Deacon JM, Chen IA BMC microbiology 31488062 BMC Microbiol 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/31488062
Phage engineering and the evolutionary arms race. Peng H, Chen IA Current opinion in biotechnology 33113495 Curr Opin Biotechnol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33113495
Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages. Peng H, Borg RE, Dow LP, Pruitt BL, Chen IA Proceedings of the National Academy of Sciences of the United States of America 31932441 Proc Natl Acad Sci U S A 2020 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/31932441
Genetically engineered filamentous phage for bacterial detection using magnetic resonance imaging. Borg RE, Ozbakir HF, Xu B, Li E, Fang X, Peng H, Chen IA, Mukherjee A Sensors & diagnostics 38405385 Sens Diagn 2023 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/38405385
Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Jacobsen JT, Hu W, R Castro TB, Solem S, Galante A, Lin Z, Allon SJ, Mesin L, Bilate AM, Schiepers A, Shalek AK, Rudensky AY, Victora GD Science (New York, N.Y.) 34437125 Science 2021 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/34437125
Allergic inflammatory memory in human respiratory epithelial progenitor cells. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH 2nd, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK Nature 30135581 Nature 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30135581
A Single Human V(H)-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood. Sangesland M, Yousif AS, Ronsard L, Kazer SW, Zhu AL, Gatter GJ, Hayward MR, Barnes RM, Quirindongo-Crespo M, Rohrer D, Lonberg N, Kwon D, Shalek AK, Lingwood D Cell reports 32846123 Cell Rep 2020 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/32846123
Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. Martin-Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb KE, Schulze Zur Wiesch J, Cubas R, Porichis F, Shalek AK, van Lunzen J, Haddad EK, Walker BD, Kaufmann DE, Lichterfeld M, Yu XG JCI insight 28138558 JCI Insight 2017 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/28138558
Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies. Sanjuan Nandin I, Fong C, Deantonio C, Torreno-Pina JA, Pecetta S, Maldonado P, Gasparrini F, Ordovas-Montanes J, Kazer SW, Kjaer S, Borley DW, Nair U, Coleman JA, Lingwood D, Shalek AK, Meffre E, Poignard P, Burton DR, Batista FD The Journal of experimental medicine 28739603 J Exp Med 2017 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/28739603
Antiviral CD8(+) T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB, Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, Crawford F, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ, Kappler JW, Walker BD Immunity 27760342 Immunity 2016 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/27760342
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer. Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR Proceedings of the National Academy of Sciences of the United States of America 30674677 Proc Natl Acad Sci U S A 2019 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/30674677
Single-cell analyses to tailor treatments. Shalek AK, Benson M Science translational medicine 28931656 Sci Transl Med 2017 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/28931656
Identification of a Master Regulator of Differentiation in Toxoplasma. Waldman BS, Schwarz D, Wadsworth MH 2nd, Saeij JP, Shalek AK, Lourido S Cell 31955846 Cell 2020 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/31955846
PI3Kβ controls immune evasion in PTEN-deficient breast tumours. Bergholz JS, Wang Q, Wang Q, Ramseier M, Prakadan S, Wang W, Fang R, Kabraji S, Zhou Q, Gray GK, Abell-Hart K, Xie S, Guo X, Gu H, Von T, Jiang T, Tang S, Freeman GJ, Kim HJ, Shalek AK, Roberts TM, Zhao JJ Nature 37076617 Nature 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37076617
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Mead BE, Hattori K, Levy L, Imada S, Goto N, Vukovic M, Sze D, Kummerlowe C, Matute JD, Duan J, Langer R, Blumberg RS, Ordovas-Montanes J, Yilmaz ÖH, Karp JM, Shalek AK Nature biomedical engineering 35314801 Nat Biomed Eng 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35314801
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration. Pepe-Mooney BJ, Dill MT, Alemany A, Ordovas-Montanes J, Matsushita Y, Rao A, Sen A, Miyazaki M, Anakk S, Dawson PA, Ono N, Shalek AK, van Oudenaarden A, Camargo FD Cell stem cell 31080134 Cell Stem Cell 2019 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/31080134
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases. Gawel DR, Serra-Musach J, Lilja S, Aagesen J, Arenas A, Asking B, Bengnér M, Björkander J, Biggs S, Ernerudh J, Hjortswang H, Karlsson JE, Köpsen M, Lee EJ, Lentini A, Li X, Magnusson M, Martínez-Enguita D, Matussek A, Nestor CE, Schäfer S, Seifert O, Sonmez C, Stjernman H, Tjärnberg A, Wu S, Åkesson K, Shalek AK, Stenmarker M, Zhang H, Gustafsson M, Benson M Genome medicine 31358043 Genome Med 2019 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/31358043
Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing. Aicher TP, Carroll S, Raddi G, Gierahn T, Wadsworth MH 2nd, Hughes TK, Love C, Shalek AK Methods in molecular biology (Clifton, N.J.) 31028635 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31028635
Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity. Zhivaki D, Borriello F, Chow OA, Doran B, Fleming I, Theisen DJ, Pallis P, Shalek AK, Sokol CL, Zanoni I, Kagan JC Cell reports 33207188 Cell Rep 2020 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/33207188
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA Science (New York, N.Y.) 27124452 Science 2016 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/27124452
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Kimmerling RJ, Lee Szeto G, Li JW, Genshaft AS, Kazer SW, Payer KR, de Riba Borrajo J, Blainey PC, Irvine DJ, Shalek AK, Manalis SR Nature communications 26732280 Nat Commun 2016 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/26732280
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction. Genshaft AS, Li S, Gallant CJ, Darmanis S, Prakadan SM, Ziegler CG, Lundberg M, Fredriksson S, Hong J, Regev A, Livak KJ, Landegren U, Shalek AK Genome biology 27640647 Genome Biol 2016 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/27640647
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential. Huang S, Ziegler CGK, Austin J, Mannoun N, Vukovic M, Ordovas-Montanes J, Shalek AK, von Andrian UH Cell 33333021 Cell 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/33333021
Distribution and storage of inflammatory memory in barrier tissues. Ordovas-Montanes J, Beyaz S, Rakoff-Nahoum S, Shalek AK Nature reviews. Immunology 32015472 Nat Rev Immunol 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32015472
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis. Corleis B, Tzouanas CN, Wadsworth MH 2nd, Cho JL, Linder AH, Schiff AE, Zessin B, Stei F, Dorhoi A, Dickey AK, Medoff BD, Shalek AK, Kwon DS Science translational medicine 38055798 Sci Transl Med 2023 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/38055798
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput. Gierahn TM, Wadsworth MH 2nd, Hughes TK, Bryson BD, Butler A, Satija R, Fortune S, Love JC, Shalek AK Nature methods 28192419 Nat Methods 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28192419
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices. Prakadan SM, Shalek AK, Weitz DA Nature reviews. Genetics 28392571 Nat Rev Genet 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28392571
Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity. Burbage M, Gasparrini F, Aggarwal S, Gaya M, Arnold J, Nair U, Way M, Bruckbauer A, Batista FD eLife 29337666 Elife 2018 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/29337666
Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus. Sangesland M, Ronsard L, Kazer SW, Bals J, Boyoglu-Barnum S, Yousif AS, Barnes R, Feldman J, Quirindongo-Crespo M, McTamney PM, Rohrer D, Lonberg N, Chackerian B, Graham BS, Kanekiyo M, Shalek AK, Lingwood D Immunity 31563464 Immunity 2019 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/31563464
TCR sequencing paired with massively parallel 3' RNA-seq reveals clonotypic T cell signatures. Tu AA, Gierahn TM, Monian B, Morgan DM, Mehta NK, Ruiter B, Shreffler WG, Shalek AK, Love JC Nature immunology 31745340 Nat Immunol 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31745340
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression. Tsankov AM, Wadsworth MH 2nd, Akopian V, Charlton J, Allon SJ, Arczewska A, Mead BE, Drake RS, Smith ZD, Mikkelsen TS, Shalek AK, Meissner A Development (Cambridge, England) 31515224 Development 2019 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/31515224
Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents. Lossos C, Liu Y, Kolb KE, Christie AL, Van Scoyk A, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM Cancer discovery 31040105 Cancer Discov 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31040105
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. Genshaft AS, Ziegler CGK, Tzouanas CN, Mead BE, Jaeger AM, Navia AW, King RP, Mana MD, Huang S, Mitsialis V, Snapper SB, Yilmaz ÖH, Jacks T, Van Humbeck JF, Shalek AK Nature communications 34404785 Nat Commun 2021 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/34404785
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. Pae J, Ersching J, Castro TBR, Schips M, Mesin L, Allon SJ, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek AK, Meyer-Hermann M, Victora GD The Journal of experimental medicine 33332554 J Exp Med 2021 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/33332554
A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers. Martin-Gayo E, Cole MB, Kolb KE, Ouyang Z, Cronin J, Kazer SW, Ordovas-Montanes J, Lichterfeld M, Walker BD, Yosef N, Shalek AK, Yu XG Genome biology 29378643 Genome Biol 2018 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/29378643
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense. Wellford SA, Chen CW, Vukovic M, Batich KA, Lin E, Shalek AK, Ordovas-Montanes J, Moseman AP, Moseman EA Mucosal immunology 39074615 Mucosal Immunol 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39074615
The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Long AF, Kuhn J, Dumont S Current opinion in cell biology 31132675 Curr Opin Cell Biol 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31132675
Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. Kuhn J, Dumont S The Journal of cell biology 28536121 J Cell Biol 2017 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/28536121
MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A Cell reports 32160543 Cell Rep 2020 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/32160543
NuMA recruits dynein activity to microtubule minus-ends at mitosis. Hueschen CL, Kenny SJ, Xu K, Dumont S eLife 29185983 Elife 2017 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/29185983
The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. Karg T, Elting MW, Vicars H, Dumont S, Sullivan W The Journal of cell biology 28500183 J Cell Biol 2017 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/28500183
Opposing motors provide mechanical and functional robustness in the human spindle. Neahring L, Cho NH, Dumont S Developmental cell 34614397 Dev Cell 2021 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/34614397
Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Long AF, Udy DB, Dumont S Current biology : CB 28552353 Curr Biol 2017 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/28552353
The Spindle: Integrating Architecture and Mechanics across Scales. Elting MW, Suresh P, Dumont S Trends in cell biology 30093097 Trends Cell Biol 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30093097
Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S Molecular biology of the cell 28468979 Mol Biol Cell 2017 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/28468979
Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Elting MW, Prakash M, Udy DB, Dumont S Current biology : CB 28690110 Curr Biol 2017 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/28690110
The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S The Journal of cell biology 33044554 J Cell Biol 2020 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/33044554
Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S Current biology : CB 30744975 Curr Biol 2019 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/30744975
Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure. Long AF, Suresh P, Dumont S The Journal of cell biology 32435797 J Cell Biol 2020 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/32435797
Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. Kuhn J, Dumont S The Journal of cell biology 31492713 J Cell Biol 2019 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/31492713
Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. Suresh P, Long AF, Dumont S eLife 32191206 Elife 2020 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/32191206
The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Rosas-Salvans M, Sutanto R, Suresh P, Dumont S Current biology : CB 35580605 Curr Biol 2022 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/35580605
Progress and challenges for chemical probing of RNA structure inside living cells. Kubota M, Tran C, Spitale RC Nature chemical biology 26575240 Nat Chem Biol 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26575240
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Bioorthogonal Metabolic Labeling of Nascent RNA in Neurons Improves the Sensitivity of Transcriptome-Wide Profiling. Zajaczkowski EL, Zhao QY, Zhang ZH, Li X, Wei W, Marshall PR, Leighton LJ, Nainar S, Feng C, Spitale RC, Bredy TW ACS chemical neuroscience 29874042 ACS Chem Neurosci 2018 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/29874042
Protected pyrimidine nucleosides for cell-specific metabolic labeling of RNA. Beasley S, Nguyen K, Fazio M, Spitale RC Tetrahedron letters 31031425 Tetrahedron Lett 2018 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/31031425
Measuring RNA structure transcriptome-wide with icSHAPE. Chan D, Feng C, Spitale RC Methods (San Diego, Calif.) 28336307 Methods 2017 May 1 https://www.ncbi.nlm.nih.gov/pubmed/28336307
Human iPSC-derived microglia: A growing toolset to study the brain's innate immune cells. Hasselmann J, Blurton-Jones M Glia 31926038 Glia 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/31926038
Evolving insights into RNA modifications and their functional diversity in the brain. Nainar S, Marshall PR, Tyler CR, Spitale RC, Bredy TW Nature neuroscience 27669990 Nat Neurosci 2016 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/27669990
Defining Functional Structured RNA inside Living Cells. Chan D, Spitale RC Biochemistry 29064690 Biochemistry 2017 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/29064690
Expanding the Scope of RNA Metabolic Labeling with Vinyl Nucleosides and Inverse Electron-Demand Diels-Alder Chemistry. Kubota M, Nainar S, Parker SM, England W, Furche F, Spitale RC ACS chemical biology 31310712 ACS Chem Biol 2019 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/31310712
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Biochemical Methods To Image and Analyze RNA Localization: From One to Many. Li Y, Ke K, Spitale RC Biochemistry 30444114 Biochemistry 2019 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/30444114
Chemical Tools for Dissecting the Role of lncRNAs in Epigenetic Regulation. Nainar S, Feng C, Spitale RC ACS chemical biology 27267401 ACS Chem Biol 2016 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/27267401
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Photo-controlled cell-specific metabolic labeling of RNA. Feng C, Li Y, Spitale RC Organic & biomolecular chemistry 28569333 Org Biomol Chem 2017 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/28569333
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M Neuron 31375314 Neuron 2019 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/31375314
A Bump-Hole Strategy for Increased Stringency of Cell-Specific Metabolic Labeling of RNA. Nguyen K, Kubota M, Arco JD, Feng C, Singha M, Beasley S, Sakr J, Gandhi SP, Blurton-Jones M, Fernández Lucas J, Spitale RC ACS chemical biology 33222436 ACS Chem Biol 2020 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/33222436
Metabolic Incorporation of Azide Functionality into Cellular RNA. Nainar S, Beasley S, Fazio M, Kubota M, Dai N, Corrêa IR Jr, Spitale RC Chembiochem : a European journal of chemical biology 27595557 Chembiochem 2016 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/27595557
Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation. Li Y, Aggarwal MB, Nguyen K, Ke K, Spitale RC ACS chemical biology 28952711 ACS Chem Biol 2017 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/28952711
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Halo-seq: An RNA Proximity Labeling Method for the Isolation and Analysis of Subcellular RNA Populations. Lo HG, Engel KL, Goering R, Li Y, Spitale RC, Taliaferro JM Current protocols 35532287 Curr Protoc 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35532287
Cycloaddition enabled mutational profiling of 5-vinyluridine in RNA. Gupta M, Wang J, Garfio CM, Vandewalle A, Spitale RC Chemical communications (Cambridge, England) 36815680 Chem Commun (Camb) 2023 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/36815680
Comparative Analysis Reveals Furoyl in Vivo Selective Hydroxyl Acylation Analyzed by Primer Extension Reagents Form Stable Ribosyl Ester Adducts. Chan D, Feng C, Zhen Y, Flynn RA, Spitale RC Biochemistry 28319368 Biochemistry 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28319368
Facile synthesis and evaluation of a dual-functioning furoyl probe for in-cell SHAPE. Chan D, Beasley S, Zhen Y, Spitale RC Bioorganic & medicinal chemistry letters 29398542 Bioorg Med Chem Lett 2018 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/29398542
Improved Analysis of RNA Localization by Spatially Restricted Oxidation of RNA-Protein Complexes. Li Y, Aggarwal MB, Ke K, Nguyen K, Spitale RC Biochemistry 29474061 Biochemistry 2018 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/29474061
Light-activated chemical probing of nucleobase solvent accessibility inside cells. Feng C, Chan D, Joseph J, Muuronen M, Coldren WH, Dai N, Corrêa IR Jr, Furche F, Hadad CM, Spitale RC Nature chemical biology 29334380 Nat Chem Biol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29334380
Spatially Restricting Bioorthogonal Nucleoside Biosynthesis Enables Selective Metabolic Labeling of the Mitochondrial Transcriptome. Nguyen K, Aggarwal MB, Feng C, Balderrama G, Fazio M, Mortazavi A, Spitale RC ACS chemical biology 29756767 ACS Chem Biol 2018 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/29756767
Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents. Li Y, Göhl M, Ke K, Vanderwal CD, Spitale RC Organic letters 31516001 Org Lett 2019 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/31516001
Mutually Orthogonal DNA Replication Systems In Vivo. Arzumanyan GA, Gabriel KN, Ravikumar A, Javanpour AA, Liu CC ACS synthetic biology 29969238 ACS Synth Biol 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/29969238
Genetic Compatibility and Extensibility of Orthogonal Replication. Javanpour AA, Liu CC ACS synthetic biology 31095905 ACS Synth Biol 2019 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/31095905
Automated Continuous Evolution of Proteins in Vivo. Zhong Z, Wong BG, Ravikumar A, Arzumanyan GA, Khalil AS, Liu CC ACS synthetic biology 32374988 ACS Synth Biol 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32374988
Rapid generation of potent antibodies by autonomous hypermutation in yeast. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC Nature chemical biology 34168368 Nat Chem Biol 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34168368
Evolving Small-Molecule Biosensors with Improved Performance and Reprogrammed Ligand Preference Using OrthoRep. Javanpour AA, Liu CC ACS synthetic biology 34597502 ACS Synth Biol 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34597502
Tunable Expression Systems for Orthogonal DNA Replication. Zhong Z, Ravikumar A, Liu CC ACS synthetic biology 30408954 ACS Synth Biol 2018 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/30408954
Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities. Rix G, Watkins-Dulaney EJ, Almhjell PJ, Boville CE, Arnold FH, Liu CC Nature communications 33159067 Nat Commun 2020 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/33159067
Rapid generation of potent antibodies by autonomous hypermutation in yeast. Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC bioRxiv : the preprint server for biology 33200136 bioRxiv 2020 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/33200136
Open-ended molecular recording of sequential cellular events into DNA. Loveless TB, Carlson CK, Dentzel Helmy CA, Hu VJ, Ross SK, Demelo MC, Murtaza A, Liang G, Ficht M, Singhai A, Pajoh-Casco MJ, Liu CC Nature chemical biology 39543397 Nat Chem Biol 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/39543397
Scalable, Continuous Evolution of Genes at Mutation Rates above Genomic Error Thresholds. Ravikumar A, Arzumanyan GA, Obadi MKA, Javanpour AA, Liu CC Cell 30415839 Cell 2018 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/30415839
Toward an orthogonal central dogma. Liu CC, Jewett MC, Chin JW, Voigt CA Nature chemical biology 29337969 Nat Chem Biol 2018 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/29337969
Synthetic Epigenetics To Engineer Regulation. Loveless TB, Liu CC Biochemistry 30860818 Biochemistry 2019 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/30860818
Probing pathways of adaptation with continuous evolution. Zhong Z, Liu CC Current opinion in systems biology 31608311 Curr Opin Syst Biol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/31608311
Lineage tracing and analog recording in mammalian cells by single-site DNA writing. Loveless TB, Grotts JH, Schechter MW, Forouzmand E, Carlson CK, Agahi BS, Liang G, Ficht M, Liu B, Xie X, Liu CC Nature chemical biology 33753928 Nat Chem Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33753928
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Genetic Engineering by DNA Recombineering. Papa LJ 3rd, Shoulders MD Current protocols in chemical biology 31483098 Curr Protoc Chem Biol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31483098
Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin. Phillips AM, Doud MB, Gonzalez LO, Butty VL, Lin YS, Bloom JD, Shoulders MD eLife 30188321 Elife 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/30188321
Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1. Moore CL, Dewal MB, Nekongo EE, Santiago S, Lu NB, Levine SS, Shoulders MD ACS chemical biology 26502114 ACS Chem Biol 2016 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/26502114
Chemical Biology Framework to Illuminate Proteostasis. Sebastian RM, Shoulders MD Annual review of biochemistry 32097570 Annu Rev Biochem 2020 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/32097570
Multidimensional chemical control of CRISPR-Cas9. Maji B, Moore CL, Zetsche B, Volz SE, Zhang F, Shoulders MD, Choudhary A Nature chemical biology 27820801 Nat Chem Biol 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27820801
Host proteostasis modulates influenza evolution. Phillips AM, Gonzalez LO, Nekongo EE, Ponomarenko AI, McHugh SM, Butty VL, Levine SS, Lin YS, Mirny LA, Shoulders MD eLife 28949290 Elife 2017 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/28949290
A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo. Moore CL, Papa LJ 3rd, Shoulders MD Journal of the American Chemical Society 29991261 J Am Chem Soc 2018 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/29991261
Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones. Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD PLoS biology 30222731 PLoS Biol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30222731
The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to Oseltamivir. Phillips AM, Shoulders MD Journal of molecular biology 26748011 J Mol Biol 2016 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/26748011
HSF1 Activation Can Restrict HIV Replication. Nekongo EE, Ponomarenko AI, Dewal MB, Butty VL, Browne EP, Shoulders MD ACS infectious diseases 32502335 ACS Infect Dis 2020 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/32502335
High-throughput Screening for Protein-based Inheritance in S. cerevisiae. Byers JS, Jarosz DF Journal of visualized experiments : JoVE 28809826 J Vis Exp 2017 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/28809826
A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program. Chakravarty AK, Smejkal T, Itakura AK, Garcia DM, Jarosz DF Molecular cell 31757755 Mol Cell 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31757755
Hsp90 shapes adaptation by controlling the fitness consequences of regulatory variation. Jakobson CM, Aguilar-Rodríguez J, Jarosz DF bioRxiv : the preprint server for biology 37961536 bioRxiv 2023 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/37961536
Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate. Chen YR, Harel I, Singh PP, Ziv I, Moses E, Goshtchevsky U, Machado BE, Brunet A, Jarosz DF Developmental cell 38810654 Dev Cell 2024 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/38810654
Massively parallel experimental interrogation of natural variants in ancient signaling pathways reveals both purifying selection and local adaptation. Aguilar-Rodríguez J, Vila J, Chen SA, Razo-Mejia M, Ghosh O, Fraser HB, Jarosz DF, Petrov DA bioRxiv : the preprint server for biology 39553990 bioRxiv 2024 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/39553990
The Hunt for Ancient Prions: Archaeal Prion-Like Domains Form Amyloid-Based Epigenetic Elements. Zajkowski T, Lee MD, Mondal SS, Carbajal A, Dec R, Brennock PD, Piast RW, Snyder JE, Bense NB, Dzwolak W, Jarosz DF, Rothschild LJ Molecular biology and evolution 33480998 Mol Biol Evol 2021 May 4 https://www.ncbi.nlm.nih.gov/pubmed/33480998
Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae. Itakura AK, Chakravarty AK, Jakobson CM, Jarosz DF Molecular cell 31757756 Mol Cell 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31757756
What Has a Century of Quantitative Genetics Taught Us About Nature's Genetic Tool Kit? Jakobson CM, Jarosz DF Annual review of genetics 32897739 Annu Rev Genet 2020 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/32897739
Organizing biochemistry in space and time using prion-like self-assembly. Jakobson CM, Jarosz DF Current opinion in systems biology 29725624 Curr Opin Syst Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29725624
It Pays To Be in Phase. Itakura AK, Futia RA, Jarosz DF Biochemistry 29509425 Biochemistry 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29509425
A common bacterial metabolite elicits prion-based bypass of glucose repression. Garcia DM, Dietrich D, Clardy J, Jarosz DF eLife 27906649 Elife 2016 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/27906649
Protein self-assembly: A new frontier in cell signaling. Saad S, Jarosz DF Current opinion in cell biology 33493989 Curr Opin Cell Biol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33493989
Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships. Jakobson CM, Jarosz DF Cell systems 31054809 Cell Syst 2019 May 22 https://www.ncbi.nlm.nih.gov/pubmed/31054809
A prion accelerates proliferation at the expense of lifespan. Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF eLife 34545808 Elife 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34545808
Protein aggregation and the evolution of stress resistance in clinical yeast. Chen YR, Ziv I, Swaminathan K, Elias JE, Jarosz DF Philosophical transactions of the Royal Society of London. Series B, Biological sciences 33866806 Philos Trans R Soc Lond B Biol Sci 2021 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/33866806
A Prion Epigenetic Switch Establishes an Active Chromatin State. Harvey ZH, Chakravarty AK, Futia RA, Jarosz DF Cell 32109413 Cell 2020 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/32109413
Biomolecular Condensation: A New Phase in Cancer Research. Chakravarty AK, McGrail DJ, Lozanoski TM, Dunn BS, Shih DJH, Cirillo KM, Cetinkaya SH, Zheng WJ, Mills GB, Yi SS, Jarosz DF, Sahni N Cancer discovery 35852417 Cancer Discov 2022 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/35852417
The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective. Aguilar-Rodríguez J, Jakobson CM, Jarosz DF Journal of molecular biology 39481633 J Mol Biol 2024 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/39481633
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Chakrabortee S, Byers JS, Jones S, Garcia DM, Bhullar B, Chang A, She R, Lee L, Fremin B, Lindquist S, Jarosz DF Cell 27693355 Cell 2016 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/27693355
Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, Chakravarty AK, Layton CJ, Chircus LM, Andreasson JO, Damaraju N, McMahon PL, Buenrostro JD, Jarosz DF, Greenleaf WJ Proceedings of the National Academy of Sciences of the United States of America 28325876 Proc Natl Acad Sci U S A 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28325876
Mutations, protein homeostasis, and epigenetic control of genome integrity. Xie JL, Jarosz DF DNA repair 30181040 DNA Repair (Amst) 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30181040
More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change. Chakravarty AK, Jarosz DF Journal of molecular biology 30031007 J Mol Biol 2018 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/30031007
Mapping Causal Variants with Single-Nucleotide Resolution Reveals Biochemical Drivers of Phenotypic Change. She R, Jarosz DF Cell 29373829 Cell 2018 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/29373829
Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae. Jakobson CM, She R, Jarosz DF Nature communications 30874558 Nat Commun 2019 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/30874558
Protein-Based Inheritance: Epigenetics beyond the Chromosome. Harvey ZH, Chen Y, Jarosz DF Molecular cell 29153393 Mol Cell 2018 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/29153393
A genome-to-proteome atlas charts natural variants controlling proteome diversity and forecasts their fitness effects. Jakobson CM, Hartl J, Trébulle P, Mülleder M, Jarosz DF, Ralser M bioRxiv : the preprint server for biology 39484408 bioRxiv 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/39484408
A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K PLoS biology 30148842 PLoS Biol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30148842
Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT Nature biotechnology 29334369 Nat Biotechnol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29334369
Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. Kanfer G, Sarraf SA, Maman Y, Baldwin H, Dominguez-Martin E, Johnson KR, Ward ME, Kampmann M, Lippincott-Schwartz J, Youle RJ The Journal of cell biology 33464298 J Cell Biol 2021 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/33464298
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M Neuron 31422865 Neuron 2019 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/31422865
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M The Journal of biological chemistry 31578281 J Biol Chem 2019 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/31578281
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J Molecular cell 35063133 Mol Cell 2022 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/35063133
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M Nature neuroscience 35953545 Nat Neurosci 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35953545
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine. Kampmann M ACS chemical biology 29035510 ACS Chem Biol 2018 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/29035510
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS eLife 27661255 Elife 2016 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/27661255
A CRISPR Approach to Neurodegenerative Diseases. Kampmann M Trends in molecular medicine 28478951 Trends Mol Med 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28478951
Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Kampmann M Chemical communications (Cambridge, England) 28487920 Chem Commun (Camb) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28487920
An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J Cell 36638793 Cell 2023 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/36638793
The mTOR Complex Controls HIV Latency. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E Cell host & microbe 27978436 Cell Host Microbe 2016 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/27978436
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS Scientific reports 29686391 Sci Rep 2018 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/29686391
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS Biology open 30037883 Biol Open 2018 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/30037883
CRISPulator: a discrete simulation tool for pooled genetic screens. Nagy T, Kampmann M BMC bioinformatics 28732459 BMC Bioinformatics 2017 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/28732459
Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability. Abrams J, Arhar T, Mok SA, Taylor IR, Kampmann M, Gestwicki JE Cell stress & chaperones 33547632 Cell Stress Chaperones 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33547632
A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. Semesta KM, Tian R, Kampmann M, von Zastrow M, Tsvetanova NG PLoS genetics 33052901 PLoS Genet 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33052901
Defining the ATPome reveals cross-optimization of metabolic pathways. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K Nature communications 32859923 Nat Commun 2020 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/32859923
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M ACS chemical biology 32786289 ACS Chem Biol 2020 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/32786289
CRISPR-based functional genomics for neurological disease. Kampmann M Nature reviews. Neurology 32641861 Nat Rev Neurol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32641861
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS Cell 33838111 Cell 2021 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/33838111
Mapping the Genetic Landscape of Human Cells. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA Cell 30033366 Cell 2018 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/30033366
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ Cell 30053424 Cell 2018 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/30053424
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L Science (New York, N.Y.) 30765536 Science 2019 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/30765536
LRP1 is a master regulator of tau uptake and spread. Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS Nature 32296178 Nature 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32296178
Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast. Eisenberg AR, Higdon AL, Hollerer I, Fields AP, Jungreis I, Diamond PD, Kellis M, Jovanovic M, Brar GA Cell systems 32710835 Cell Syst 2020 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/32710835
Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis. Eisenberg AR, Higdon A, Keskin A, Hodapp S, Jovanovic M, Brar GA Cell reports 30590036 Cell Rep 2018 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/30590036
Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. Cheng Z, Mugler CF, Keskin A, Hodapp S, Chan LY, Weis K, Mertins P, Regev A, Jovanovic M, Brar GA Molecular cell 30503772 Mol Cell 2019 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/30503772
Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms. Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA Developmental cell 30016623 Dev Cell 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30016623
Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster. Jorgensen V, Chen J, Vander Wende H, Harris DE, McCarthy A, Breznak S, Wong-Deyrup SW, Chen Y, Rangan P, Brar GA, Sawyer EM, Chan LY, Ünal E G3 (Bethesda, Md.) 32213532 G3 (Bethesda) 2020 May 4 https://www.ncbi.nlm.nih.gov/pubmed/32213532
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Frequency-chirped dynamic nuclear polarization with magic angle spinning using a frequency-agile gyrotron. Gao C, Alaniva N, Saliba EP, Sesti EL, Judge PT, Scott FJ, Halbritter T, Sigurdsson ST, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 31525550 J Magn Reson 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31525550
Dynamic Nuclear Polarization Nuclear Magnetic Resonance in Human Cells Using Fluorescent Polarizing Agents. Albert BJ, Gao C, Sesti EL, Saliba EP, Alaniva N, Scott FJ, Sigurdsson ST, Barnes AB Biochemistry 29924582 Biochemistry 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/29924582
Electron Decoupling with Dynamic Nuclear Polarization in Rotating Solids. Saliba EP, Sesti EL, Scott FJ, Albert BJ, Choi EJ, Alaniva N, Gao C, Barnes AB Journal of the American Chemical Society 28429936 J Am Chem Soc 2017 May 10 https://www.ncbi.nlm.nih.gov/pubmed/28429936
Instrumentation for cryogenic magic angle spinning dynamic nuclear polarization using 90L of liquid nitrogen per day. Albert BJ, Pahng SH, Alaniva N, Sesti EL, Rand PW, Saliba EP, Scott FJ, Choi EJ, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 28888182 J Magn Reson 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28888182
Magic angle spinning NMR with metallized rotors as cylindrical microwave resonators. Scott FJ, Sesti EL, Choi EJ, Laut AJ, Sirigiri JR, Barnes AB Magnetic resonance in chemistry : MRC 29672916 Magn Reson Chem 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/29672916
Magic angle spinning NMR below 6 K with a computational fluid dynamics analysis of fluid flow and temperature gradients. Sesti EL, Alaniva N, Rand PW, Choi EJ, Albert BJ, Saliba EP, Scott FJ, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 29161649 J Magn Reson 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29161649
Dynamic Nuclear Polarization with Electron Decoupling in Intact Human Cells and Cell Lysates. Judge PT, Sesti EL, Price LE, Albert BJ, Alaniva N, Saliba EP, Halbritter T, Sigurdsson ST, Kyei GB, Barnes AB The journal of physical chemistry. B 32083876 J Phys Chem B 2020 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/32083876
Sensitivity analysis of magic angle spinning dynamic nuclear polarization below 6 K. Judge PT, Sesti EL, Saliba EP, Alaniva N, Halbritter T, Sigurdsson ST, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 31212198 J Magn Reson 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31212198
Frequency swept microwaves for hyperfine decoupling and time domain dynamic nuclear polarization. Hoff DE, Albert BJ, Saliba EP, Scott FJ, Choi EJ, Mardini M, Barnes AB Solid state nuclear magnetic resonance 26482131 Solid State Nucl Magn Reson 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26482131
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation. Albert BJ, Niu A, Ramani R, Marshall GR, Wender PA, Williams RM, Ratner L, Barnes AB, Kyei GB Scientific reports 28785069 Sci Rep 2017 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/28785069
A versatile custom cryostat for dynamic nuclear polarization supports multiple cryogenic magic angle spinning transmission line probes. Scott FJ, Alaniva N, Golota NC, Sesti EL, Saliba EP, Price LE, Albert BJ, Chen P, O'Connor RD, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 30342370 J Magn Reson 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30342370
Magic angle spinning spheres. Chen P, Albert BJ, Gao C, Alaniva N, Price LE, Scott FJ, Saliba EP, Sesti EL, Judge PT, Fisher EW, Barnes AB Science advances 30255153 Sci Adv 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30255153
Pulsed Electron Decoupling and Strategies for Time Domain Dynamic Nuclear Polarization with Magic Angle Spinning. Saliba EP, Sesti EL, Alaniva N, Barnes AB The journal of physical chemistry letters 30180584 J Phys Chem Lett 2018 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/30180584
Electron decoupling with cross polarization and dynamic nuclear polarization below 6 K. Sesti EL, Saliba EP, Alaniva N, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 30077145 J Magn Reson 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30077145
Characterization of frequency-chirped dynamic nuclear polarization in rotating solids. Judge PT, Sesti EL, Alaniva N, Saliba EP, Price LE, Gao C, Halbritter T, Sigurdsson ST, Kyei GB, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 32203923 J Magn Reson 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32203923
Fast electron paramagnetic resonance magic angle spinning simulations using analytical powder averaging techniques. Saliba EP, Barnes AB The Journal of chemical physics 31542017 J Chem Phys 2019 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/31542017
Frequency-agile gyrotron for electron decoupling and pulsed dynamic nuclear polarization. Scott FJ, Saliba EP, Albert BJ, Alaniva N, Sesti EL, Gao C, Golota NC, Choi EJ, Jagtap AP, Wittmann JJ, Eckardt M, Harneit W, Corzilius B, Th Sigurdsson S, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 29471275 J Magn Reson 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29471275
Akt3 is a privileged first responder in isozyme-specific electrophile response. Long MJ, Parvez S, Zhao Y, Surya SL, Wang Y, Zhang S, Aye Y Nature chemical biology 28114274 Nat Chem Biol 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28114274
A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. Lin HY, Haegele JA, Disare MT, Lin Q, Aye Y Journal of the American Chemical Society 25909755 J Am Chem Soc 2015 May 20 https://www.ncbi.nlm.nih.gov/pubmed/25909755
Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition. Wisitpitthaya S, Zhao Y, Long MJ, Li M, Fletcher EA, Blessing WA, Weiss RS, Aye Y ACS chemical biology 27159113 ACS Chem Biol 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27159113
T-REX on-demand redox targeting in live cells. Parvez S, Long MJ, Lin HY, Zhao Y, Haegele JA, Pham VN, Lee DK, Aye Y Nature protocols 27809314 Nat Protoc 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27809314
Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology. Long MJ, Poganik JR, Ghosh S, Aye Y ACS chemical biology 28068059 ACS Chem Biol 2017 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/28068059
Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor. Surya SL, Long MJC, Urul DA, Zhao Y, Mercer EJ, EIsaid IM, Evans T, Aye Y ACS chemical biology 29397684 ACS Chem Biol 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/29397684
Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation. Khatri HR, Bhattarai B, Kaplan W, Li Z, Curtis Long MJ, Aye Y, Nagorny P Journal of the American Chemical Society 30802047 J Am Chem Soc 2019 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/30802047
Genie in a bottle: controlled release helps tame natural polypharmacology? Long MJ, Liu X, Aye Y Current opinion in chemical biology 30913473 Curr Opin Chem Biol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/30913473
The Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making. Long MJC, Aye Y Chemical research in toxicology 27617777 Chem Res Toxicol 2016 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/27617777
Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1. Poganik JR, Long MJC, Disare MT, Liu X, Chang SH, Hla T, Aye Y FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31665914 FASEB J 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31665914
Empowering Global Chemical Biology at the Dawn of the New Decade. Hoogendoorn S, Aye Y ACS chemical biology 32315151 ACS Chem Biol 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32315151
Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis. Long MJC, Zhao Y, Aye Y Cell chemical biology 31836351 Cell Chem Biol 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31836351
Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities. Long MJC, Zhao Y, Aye Y RSC chemical biology 34458747 RSC Chem Biol 2020 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/34458747
Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery. Long MJC, Hnedzko D, Kim BK, Aye Y Chembiochem : a European journal of chemical biology 30589188 Chembiochem 2019 May 2 https://www.ncbi.nlm.nih.gov/pubmed/30589188
Redox Signaling by Reactive Electrophiles and Oxidants. Parvez S, Long MJC, Poganik JR, Aye Y Chemical reviews 30148624 Chem Rev 2018 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/30148624
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3. Fu Y, Long MJC, Wisitpitthaya S, Inayat H, Pierpont TM, Elsaid IM, Bloom JC, Ortega J, Weiss RS, Aye Y Nature chemical biology 30150681 Nat Chem Biol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30150681
Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response. Parvez S, Fu Y, Li J, Long MJ, Lin HY, Lee DK, Hu GS, Aye Y Journal of the American Chemical Society 25544059 J Am Chem Soc 2015 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/25544059
Single-Protein-Specific Redox Targeting in Live Mammalian Cells and C. elegans. Van Hall-Beauvais A, Zhao Y, Urul DA, Long MJC, Aye Y Current protocols in chemical biology 30085412 Curr Protoc Chem Biol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30085412
Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles. Liu X, Long MJC, Aye Y Trends in biochemical sciences 30327250 Trends Biochem Sci 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30327250
β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y Cell chemical biology 28736239 Cell Chem Biol 2017 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/28736239
Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity. Long MJC, Liu X, Aye Y Frontiers in chemistry 30949469 Front Chem 2019 https://www.ncbi.nlm.nih.gov/pubmed/30949469
Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals. Poganik JR, Aye Y Frontiers in aging neuroscience 32116644 Front Aging Neurosci 2020 https://www.ncbi.nlm.nih.gov/pubmed/32116644
REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins. Long MJC, Urul DA, Aye Y Methods in enzymology 32046846 Methods Enzymol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32046846
The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor. Poganik JR, Van Hall-Beauvais AK, Long MJC, Disare MT, Zhao Y, Aye Y Helvetica chimica acta 34113045 Helv Chim Acta 2020 May https://www.ncbi.nlm.nih.gov/pubmed/34113045
On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry. Long MJ, Poganik JR, Aye Y Journal of the American Chemical Society 26907082 J Am Chem Soc 2016 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/26907082
Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators. Poganik JR, Long MJC, Aye Y BioEssays : news and reviews in molecular, cellular and developmental biology 29603288 Bioessays 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29603288
Privileged Electrophile Sensors: A Resource for Covalent Drug Development. Long MJC, Aye Y Cell chemical biology 28648380 Cell Chem Biol 2017 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/28648380
Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling. Long MJC, Wang L, Aye Y Antioxidants & redox signaling 31578876 Antioxid Redox Signal 2020 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/31578876
The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase. Long MJC, Van Hall-Beauvais A, Aye Y Current opinion in chemical biology 31734537 Curr Opin Chem Biol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31734537
Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses. Zhao Y, Long MJC, Wang Y, Zhang S, Aye Y ACS central science 29532025 ACS Cent Sci 2018 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/29532025
Weighing up the Selenocysteome Uncovers New Sec-rets. Poganik JR, Aye Y Cell chemical biology 30445052 Cell Chem Biol 2018 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/30445052
Optimal Design of Single-Cell Experiments within Temporally Fluctuating Environments. Fox ZR, Neuert G, Munsky B Complexity 32982137 Complexity 2020 https://www.ncbi.nlm.nih.gov/pubmed/32982137
From analog to digital models of gene regulation. Munsky B, Neuert G Physical biology 26086470 Phys Biol 2015 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/26086470
Phenotypic consequences of logarithmic signaling in MAPK stress response. Jashnsaz H, Neuert G bioRxiv : the preprint server for biology 38106069 bioRxiv 2023 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/38106069
Modelling patient drug exposure profiles in vitro to narrow the valley of death. Leasure CS, Neuert G Nature reviews bioengineering 38873361 Nat Rev Bioeng 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38873361
Automated cell boundary and 3D nuclear segmentation of cells in suspension. Kesler B, Li G, Thiemicke A, Venkat R, Neuert G Scientific reports 31308458 Sci Rep 2019 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/31308458
Multiplex RNA single molecule FISH of inducible mRNAs in single yeast cells. Li G, Neuert G Scientific data 31209217 Sci Data 2019 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/31209217
Integrating single-molecule experiments and discrete stochastic models to understand heterogeneous gene transcription dynamics. Munsky B, Fox Z, Neuert G Methods (San Diego, Calif.) 26079925 Methods 2015 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/26079925
A rate threshold mechanism regulates MAPK stress signaling and survival. Johnson AN, Li G, Jashnsaz H, Thiemicke A, Kesler BK, Rogers DC, Neuert G Proceedings of the National Academy of Sciences of the United States of America 33443180 Proc Natl Acad Sci U S A 2021 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/33443180
Rate thresholds in cell signaling have functional and phenotypic consequences in non-linear time-dependent environments. Thiemicke A, Neuert G Frontiers in cell and developmental biology 37025183 Front Cell Dev Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/37025183
TrueSpot: A robust automated tool for quantifying signal puncta in fluorescent imaging. Hospelhorn BG, Kesler BK, Jashnsaz H, Neuert G bioRxiv : the preprint server for biology 39868229 bioRxiv 2025 May 21 https://www.ncbi.nlm.nih.gov/pubmed/39868229
Distribution shapes govern the discovery of predictive models for gene regulation. Munsky B, Li G, Fox ZR, Shepherd DP, Neuert G Proceedings of the National Academy of Sciences of the United States of America 29959206 Proc Natl Acad Sci U S A 2018 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/29959206
Finite state projection based bounds to compare chemical master equation models using single-cell data. Fox Z, Neuert G, Munsky B The Journal of chemical physics 27544081 J Chem Phys 2016 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/27544081
Kinetics of osmotic stress regulate a cell fate switch of cell survival. Thiemicke A, Neuert G Science advances 33608274 Sci Adv 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33608274
Generating kinetic environments to study dynamic cellular processes in single cells. Thiemicke A, Jashnsaz H, Li G, Neuert G Scientific reports 31300695 Sci Rep 2019 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/31300695
Diverse Cell Stimulation Kinetics Identify Predictive Signal Transduction Models. Jashnsaz H, Fox ZR, Hughes JJ, Li G, Munsky B, Neuert G iScience 33083733 iScience 2020 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/33083733
Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL Molecular pharmaceutics 26262434 Mol Pharm 2015 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/26262434
Enrichment of S-Palmitoylated Proteins for Mass Spectrometry Analysis. Cheung See Kit M, Martin BR Methods in molecular biology (Clifton, N.J.) 31152396 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31152396
Targeted Annotation of S-Sulfonylated Peptides by Selective Infrared Multiphoton Dissociation Mass Spectrometry. Borotto NB, McClory PJ, Martin BR, Håkansson K Analytical chemistry 28708386 Anal Chem 2017 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/28708386
APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells. Hernandez JL, Davda D, Cheung See Kit M, Majmudar JD, Won SJ, Gang M, Pasupuleti SC, Choi AI, Bartkowiak CM, Martin BR Cell chemical biology 28065656 Cell Chem Biol 2017 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/28065656
Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. Won SJ, Martin BR ACS chemical biology 29733200 ACS Chem Biol 2018 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/29733200
Protein depalmitoylases. Won SJ, Cheung See Kit M, Martin BR Critical reviews in biochemistry and molecular biology 29239216 Crit Rev Biochem Mol Biol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29239216
HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking. Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA Journal of the American Chemical Society 29035536 J Am Chem Soc 2017 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/29035536
Chemoselective ratiometric imaging of protein S-sulfenylation. Tom CTMB, Crellin JE, Motiwala HF, Stone MB, Davda D, Walker W, Kuo YH, Hernandez JL, Labby KJ, Gomez-Rodriguez L, Jenkins PM, Veatch SL, Martin BR Chemical communications (Cambridge, England) 28613292 Chem Commun (Camb) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28613292
DIA-SIFT: A Precursor and Product Ion Filter for Accurate Stable Isotope Data-Independent Acquisition Proteomics. Haynes SE, Majmudar JD, Martin BR Analytical chemistry 29989796 Anal Chem 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/29989796
Free Radical Initiated Peptide Sequencing for Direct Site Localization of Sulfation and Phosphorylation with Negative Ion Mode Mass Spectrometry. Borotto NB, Ileka KM, Tom CATMB, Martin BR, Håkansson K Analytical chemistry 30063332 Anal Chem 2018 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/30063332
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). Won SJ, Davda D, Labby KJ, Hwang SY, Pricer R, Majmudar JD, Armacost KA, Rodriguez LA, Rodriguez CL, Chong FS, Torossian KA, Palakurthi J, Hur ES, Meagher JL, Brooks CL 3rd, Stuckey JA, Martin BR ACS chemical biology 27748579 ACS Chem Biol 2016 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/27748579
Harnessing Redox Cross-Reactivity To Profile Distinct Cysteine Modifications. Majmudar JD, Konopko AM, Labby KJ, Tom CT, Crellin JE, Prakash A, Martin BR Journal of the American Chemical Society 26780921 J Am Chem Soc 2016 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/26780921
Variable-Velocity Traveling-Wave Ion Mobility Separation Enhancing Peak Capacity for Data-Independent Acquisition Proteomics. Haynes SE, Polasky DA, Dixit SM, Majmudar JD, Neeson K, Ruotolo BT, Martin BR Analytical chemistry 28471653 Anal Chem 2017 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/28471653
Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2. Won SJ, Eschweiler JD, Majmudar JD, Chong FS, Hwang SY, Ruotolo BT, Martin BR ACS medicinal chemistry letters 28197315 ACS Med Chem Lett 2017 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/28197315
Activated G Protein Gαs Samples Multiple Endomembrane Compartments. Martin BR, Lambert NA The Journal of biological chemistry 27528603 J Biol Chem 2016 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/27528603
Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly. ElAzzouny M, Tom CT, Evans CR, Olson LL, Tanga MJ, Gallagher KA, Martin BR, Burant CF The Journal of biological chemistry 28188288 J Biol Chem 2017 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/28188288
Profiling Protein S-Sulfination with Maleimide-Linked Probes. Kuo YH, Konopko AM, Borotto NB, Majmudar JD, Haynes SE, Martin BR Chembiochem : a European journal of chemical biology 28809078 Chembiochem 2017 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/28809078
Global Analysis of Palmitoylated Proteins in Toxoplasma gondii. Foe IT, Child MA, Majmudar JD, Krishnamurthy S, van der Linden WA, Ward GE, Martin BR, Bogyo M Cell host & microbe 26468752 Cell Host Microbe 2015 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/26468752
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation. Zhao D, Yin Z, Soellner MB, Martin BR Cell chemical biology 33730553 Cell Chem Biol 2021 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/33730553
Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition. Hernandez JL, Davda D, Majmudar JD, Won SJ, Prakash A, Choi AI, Martin BR Molecular bioSystems 27030425 Mol Biosyst 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27030425
Tunable Heteroaromatic Sulfones Enhance in-Cell Cysteine Profiling. Motiwala HF, Kuo YH, Stinger BL, Palfey BA, Martin BR Journal of the American Chemical Society 31881155 J Am Chem Soc 2020 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/31881155
DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching. Powell JT, Akhuetie-Oni BO, Zhang Z, Lin C Angewandte Chemie (International ed. in English) 27527591 Angew Chem Int Ed Engl 2016 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/27527591
FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. Landajuela A, Braun M, Rodrigues CDA, Martínez-Calvo A, Doan T, Horenkamp F, Andronicos A, Shteyn V, Williams ND, Lin C, Wingreen NS, Rudner DZ, Karatekin E PLoS biology 34185788 PLoS Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34185788
Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging. Chung KKH, Zhang Z, Kidd P, Zhang Y, Williams ND, Rollins B, Yang Y, Lin C, Baddeley D, Bewersdorf J Nature methods 35501386 Nat Methods 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35501386
Vesicle Tubulation with Self-Assembling DNA Nanosprings. Grome MW, Zhang Z, Pincet F, Lin C Angewandte Chemie (International ed. in English) 29575478 Angew Chem Int Ed Engl 2018 May 4 https://www.ncbi.nlm.nih.gov/pubmed/29575478
Directing reconfigurable DNA nanoarrays. Yang Y, Lin C Science (New York, N.Y.) 28751594 Science 2017 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/28751594
A programmable DNA-origami platform for studying lipid transfer between bilayers. Bian X, Zhang Z, Xiong Q, De Camilli P, Lin C Nature chemical biology 31320758 Nat Chem Biol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31320758
A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement. Fisher PDE, Shen Q, Akpinar B, Davis LK, Chung KKH, Baddeley D, Šarić A, Melia TJ, Hoogenboom BW, Lin C, Lusk CP ACS nano 29350911 ACS Nano 2018 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/29350911
Placing and shaping liposomes with reconfigurable DNA nanocages. Zhang Z, Yang Y, Pincet F, Llaguno MC, Lin C Nature chemistry 28644472 Nat Chem 2017 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/28644472
DNA-Origami-Based Fluorescence Brightness Standards for Convenient and Fast Protein Counting in Live Cells. Williams ND, Landajuela A, Kasula RK, Zhou W, Powell JT, Xi Z, Isaacs FJ, Berro J, Toomre D, Karatekin E, Lin C Nano letters 33164530 Nano Lett 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33164530
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Yang Y, Wu Z, Wang L, Zhou K, Xia K, Xiong Q, Liu L, Zhang Z, Chapman ER, Xiong Y, Melia TJ, Karatekin E, Gu H, Lin C Nature chemistry 33785892 Nat Chem 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33785892
Engineering Lipid Membranes with Programmable DNA Nanostructures. Shen Q, Grome MW, Yang Y, Lin C Advanced biosystems 31934608 Adv Biosyst 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31934608
Stiffness and Membrane Anchor Density Modulate DNA-Nanospring-Induced Vesicle Tubulation. Grome MW, Zhang Z, Lin C ACS applied materials & interfaces 31252462 ACS Appl Mater Interfaces 2019 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/31252462
DNA Origami Post-Processing by CRISPR-Cas12a. Xiong Q, Xie C, Zhang Z, Liu L, Powell JT, Shen Q, Lin C Angewandte Chemie (International ed. in English) 31883145 Angew Chem Int Ed Engl 2020 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/31883145
Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross. Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW eLife 33179598 Elife 2020 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/33179598
Systematic Dissection of Sequence Elements Controlling σ70 Promoters Using a Genomically Encoded Multiplexed Reporter Assay in Escherichia coli. Urtecho G, Tripp AD, Insigne KD, Kim H, Kosuri S Biochemistry 29388765 Biochemistry 2019 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/29388765
A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing. Jones EM, Jajoo R, Cancilla D, Lubock NB, Wang J, Satyadi M, Chong R, de March C, Bloom JS, Matsunami H, Kosuri S Cell systems 30904378 Cell Syst 2019 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/30904378
Highly parallel genome variant engineering with CRISPR-Cas9. Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L Nature genetics 29632376 Nat Genet 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29632376
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A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control. Strobel EJ, Cheng L, Berman KE, Carlson PD, Lucks JB Nature chemical biology 31636437 Nat Chem Biol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31636437
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Choosing the right pharmacotherapeutic strategy for HIV maintenance in patients with alcohol addiction. Kodidela S, Kumar S Expert opinion on pharmacotherapy 30724618 Expert Opin Pharmacother 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30724618
Characterizing the Structure-Function Relationship of a Naturally Occurring RNA Thermometer. Meyer S, Carlson PD, Lucks JB Biochemistry 29172455 Biochemistry 2017 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/29172455
An underlying mechanism for the increased mutagenesis of lagging-strand genes in Bacillus subtilis. Million-Weaver S, Samadpour AN, Moreno-Habel DA, Nugent P, Brittnacher MJ, Weiss E, Hayden HS, Miller SI, Liachko I, Merrikh H Proceedings of the National Academy of Sciences of the United States of America 25713353 Proc Natl Acad Sci U S A 2015 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/25713353
Inhibiting the Evolution of Antibiotic Resistance. Ragheb MN, Thomason MK, Hsu C, Nugent P, Gage J, Samadpour AN, Kariisa A, Merrikh CN, Miller SI, Sherman DR, Merrikh H Molecular cell 30449724 Mol Cell 2019 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/30449724
Gene inversion potentiates bacterial evolvability and virulence. Merrikh CN, Merrikh H Nature communications 30405125 Nat Commun 2018 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/30405125
Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts. Lang KS, Merrikh H Cell reports 33657379 Cell Rep 2021 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/33657379
The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units. Merrikh CN, Brewer BJ, Merrikh H PLoS genetics 26070154 PLoS Genet 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/26070154
The bacterial replisome has factory-like localization. Mangiameli SM, Cass JA, Merrikh H, Wiggins PA Current genetics 29632994 Curr Genet 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29632994
The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria. Lang KS, Merrikh H Annual review of microbiology 29856930 Annu Rev Microbiol 2018 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/29856930
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Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis. Lang KS, Hall AN, Merrikh CN, Ragheb M, Tabakh H, Pollock AJ, Woodward JJ, Dreifus JE, Merrikh H Cell 28802046 Cell 2017 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/28802046
DNA gyrase activity regulates DnaA-dependent replication initiation in Bacillus subtilis. Samadpour AN, Merrikh H Molecular microbiology 29396913 Mol Microbiol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29396913
The Accelerated Evolution of Lagging Strand Genes Is Independent of Sequence Context. Merrikh CN, Weiss E, Merrikh H Genome biology and evolution 28039230 Genome Biol Evol 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/28039230
Spatial and Temporal Control of Evolution through Replication-Transcription Conflicts. Merrikh H Trends in microbiology 28216294 Trends Microbiol 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28216294
Crystal structure of a membrane-bound O-acyltransferase. Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W Nature 30283133 Nature 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30283133
Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. Kalia R, Frost A Molecular biology of the cell 31365329 Mol Biol Cell 2019 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/31365329
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS eLife 33236988 Elife 2020 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/33236988
In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE eLife 28718767 Elife 2017 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/28718767
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A Proceedings of the National Academy of Sciences of the United States of America 28242692 Proc Natl Acad Sci U S A 2017 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/28242692
Structural basis of mitochondrial receptor binding and constriction by DRP1. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A Nature 29899447 Nature 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29899447
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P Science (New York, N.Y.) 29599213 Science 2018 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/29599213
Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. Nguyen HC, Melo AA, Kruk J, Frost A, Gabruk M Nature plants 33875834 Nat Plants 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33875834
Structural and functional studies of membrane remodeling machines. Kalia R, Talledge N, Frost A Methods in cell biology 25997348 Methods Cell Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25997348
A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ The EMBO journal 27655872 EMBO J 2016 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/27655872
Structural basis of TRPV1 modulation by endogenous bioactive lipids. Arnold WR, Mancino A, Moss FR 3rd, Frost A, Julius D, Cheng Y Nature structural & molecular biology 38698206 Nat Struct Mol Biol 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38698206
Vms1p is a release factor for the ribosome-associated quality control complex. Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J Nature communications 29875445 Nat Commun 2018 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/29875445
CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS Science (New York, N.Y.) 28751611 Science 2017 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/28751611
Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM. Carragher B, Cheng Y, Frost A, Glaeser RM, Lander GC, Nogales E, Wang HW Journal of microscopy 31553060 J Microsc 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31553060
Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases. Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P The Journal of cell biology 31904797 J Cell Biol 2020 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/31904797
FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK Analytical chemistry 30071717 Anal Chem 2018 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/30071717
Brominated lipid probes expose structural asymmetries in constricted membranes. Moss FR 3rd, Lincoff J, Tucker M, Mohammed A, Grabe M, Frost A Nature structural & molecular biology 36624348 Nat Struct Mol Biol 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36624348
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM Proceedings of the National Academy of Sciences of the United States of America 23530241 Proc Natl Acad Sci U S A 2013 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/23530241
Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. McCullough J, Frost A, Sundquist WI Annual review of cell and developmental biology 30095293 Annu Rev Cell Dev Biol 2018 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/30095293
Cell biology: Double agents for mitochondrial division. McBride HM, Frost A Nature 27880759 Nature 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27880759
Structural inhibition of dynamin-mediated membrane fission by endophilin. Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A eLife 28933693 Elife 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28933693
Membrane fission by dynamin: what we know and what we need to know. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S The EMBO journal 27670760 EMBO J 2016 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/27670760
Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M Nature structural & molecular biology 26656853 Nat Struct Mol Biol 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26656853
Structure and membrane remodeling activity of ESCRT-III helical polymers. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A Science (New York, N.Y.) 26634441 Science 2015 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/26634441
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The genomic architecture and molecular evolution of ant odorant receptors. McKenzie SK, Kronauer DJC Genome research 30249741 Genome Res 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30249741
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Social regulation of insulin signaling and the evolution of eusociality in ants. Chandra V, Fetter-Pruneda I, Oxley PR, Ritger AL, McKenzie SK, Libbrecht R, Kronauer DJC Science (New York, N.Y.) 30049879 Science 2018 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/30049879
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The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. Elbaum-Garfinkle S, Kim Y, Szczepaniak K, Chen CC, Eckmann CR, Myong S, Brangwynne CP Proceedings of the National Academy of Sciences of the United States of America 26015579 Proc Natl Acad Sci U S A 2015 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/26015579
G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy. Lee CY, McNerney C, Myong S Methods in molecular biology (Clifton, N.J.) 31444758 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31444758
Single-molecule real-time detection of telomerase extension activity. Hwang H, Opresko P, Myong S Scientific reports 25263700 Sci Rep 2014 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/25263700
RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP. Kim Y, Myong S Molecular cell 27546789 Mol Cell 2016 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/27546789
Oxidative guanine base damage regulates human telomerase activity. Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL Nature structural & molecular biology 27820808 Nat Struct Mol Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27820808
RNA stem structure governs coupling of dicing and gene silencing in RNA interference. Koh HR, Ghanbariniaki A, Myong S Proceedings of the National Academy of Sciences of the United States of America 29133395 Proc Natl Acad Sci U S A 2017 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/29133395
Dynamic profiling of double-stranded RNA binding proteins. Wang X, Vukovic L, Koh HR, Schulten K, Myong S Nucleic acids research 26184879 Nucleic Acids Res 2015 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/26184879
Quantitative analysis and prediction of G-quadruplex forming sequences in double-stranded DNA. Kim M, Kreig A, Lee CY, Rube HT, Calvert J, Song JS, Myong S Nucleic acids research 27095201 Nucleic Acids Res 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27095201
ATP-independent diffusion of double-stranded RNA binding proteins. Koh HR, Kidwell MA, Ragunathan K, Doudna JA, Myong S Proceedings of the National Academy of Sciences of the United States of America 23251028 Proc Natl Acad Sci U S A 2013 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/23251028
Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing. Koh HR, Xing L, Kleiman L, Myong S Nucleic acids research 24914047 Nucleic Acids Res 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24914047
Molecular mechanism of resolving trinucleotide repeat hairpin by helicases. Qiu Y, Niu H, Vukovic L, Sung P, Myong S Structure (London, England : 1993) 26004439 Structure 2015 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/26004439
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Chen MC, Tippana R, Demeshkina NA, Murat P, Balasubramanian S, Myong S, Ferré-D'Amaré AR Nature 29899445 Nature 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29899445
POT1-TPP1 regulates telomeric overhang structural dynamics. Hwang H, Buncher N, Opresko PL, Myong S Structure (London, England : 1993) 22981946 Structure 2012 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/22981946
RNA Scanning of a Molecular Machine with a Built-in Ruler. Koh HR, Kidwell MA, Doudna J, Myong S Journal of the American Chemical Society 27958730 J Am Chem Soc 2017 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/27958730
Visualizing repetitive diffusion activity of double-strand RNA binding proteins by single molecule fluorescence assays. Koh HR, Wang X, Myong S Methods (San Diego, Calif.) 27012177 Methods 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/27012177
Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases. Tippana R, Hwang H, Opresko PL, Bohr VA, Myong S Proceedings of the National Academy of Sciences of the United States of America 27407146 Proc Natl Acad Sci U S A 2016 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/27407146
G-quadruplex formation in double strand DNA probed by NMM and CV fluorescence. Kreig A, Calvert J, Sanoica J, Cullum E, Tipanna R, Myong S Nucleic acids research 26202971 Nucleic Acids Res 2015 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/26202971
Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, Costello JF Science (New York, N.Y.) 25977370 Science 2015 May 29 https://www.ncbi.nlm.nih.gov/pubmed/25977370
Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteins. Hwang H, Kreig A, Calvert J, Lormand J, Kwon Y, Daley JM, Sung P, Opresko PL, Myong S Structure (London, England : 1993) 24836024 Structure 2014 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/24836024
Substrate recognition and specificity of double-stranded RNA binding proteins. Vuković L, Koh HR, Myong S, Schulten K Biochemistry 24801449 Biochemistry 2014 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/24801449
G-quadruplex conformation and dynamics are determined by loop length and sequence. Tippana R, Xiao W, Myong S Nucleic acids research 24920827 Nucleic Acids Res 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24920827
mRNA structure determines specificity of a polyQ-driven phase separation. Langdon EM, Qiu Y, Ghanbari Niaki A, McLaughlin GA, Weidmann CA, Gerbich TM, Smith JA, Crutchley JM, Termini CM, Weeks KM, Myong S, Gladfelter AS Science (New York, N.Y.) 29650703 Science 2018 May 25 https://www.ncbi.nlm.nih.gov/pubmed/29650703
Single-Cell Imaging Approaches for Studying Small-RNA-Induced Gene Regulation. Koh HR, Myong S Biophysical journal 29970232 Biophys J 2018 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/29970232
The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer. Qiu Y, Levendosky RF, Chakravarthy S, Patel A, Bowman GD, Myong S Molecular cell 28943314 Mol Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28943314
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R Developmental cell 29401421 Dev Cell 2018 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/29401421
Lipid droplets can promote drug accumulation and activation. Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R Nature chemical biology 31932720 Nat Chem Biol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31932720
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW EMBO reports 27113758 EMBO Rep 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27113758
Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R Cancer research 27503929 Cancer Res 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27503929
Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG Developmental cell 25936505 Dev Cell 2015 May 26 https://www.ncbi.nlm.nih.gov/pubmed/25936505
Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR. Niewiadomski P, Rohatgi R Methods in molecular biology (Clifton, N.J.) 26179041 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26179041
G-protein-coupled receptors, Hedgehog signaling and primary cilia. Mukhopadhyay S, Rohatgi R Seminars in cell & developmental biology 24845016 Semin Cell Dev Biol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/24845016
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R eLife 27996937 Elife 2016 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/27996937
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R Developmental cell 29290584 Dev Cell 2018 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/29290584
G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R Science signaling 29438014 Sci Signal 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29438014
In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes. Schmidt HB, Rohatgi R Cell reports 27452472 Cell Rep 2016 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/27452472
Phase separation-deficient TDP43 remains functional in splicing. Schmidt HB, Barreau A, Rohatgi R Nature communications 31653829 Nat Commun 2019 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/31653829
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R eLife 31657721 Elife 2019 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/31657721
Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry. Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R Methods in molecular biology (Clifton, N.J.) 26179043 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26179043
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T Cell 28086093 Cell 2017 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/28086093
R-spondins can potentiate WNT signaling without LGRs. Lebensohn AM, Rohatgi R eLife 29405118 Elife 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29405118
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL The EMBO journal 29438978 EMBO J 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29438978
Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens. Patel BB, Lebensohn AM, Pusapati GV, Carette JE, Salzman J, Rohatgi R PloS one 30695034 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/30695034
TDP-43 α-helical structure tunes liquid-liquid phase separation and function. Conicella AE, Dignon GL, Zerze GH, Schmidt HB, D'Ordine AM, Kim YC, Rohatgi R, Ayala YM, Mittal J, Fawzi NL Proceedings of the National Academy of Sciences of the United States of America 32132204 Proc Natl Acad Sci U S A 2020 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/32132204
Rapid Screening of Gli2/3 Mutants Using the Flp-In System. Niewiadomski P, Rohatgi R Methods in molecular biology (Clifton, N.J.) 26179044 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26179044
Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC Nature communications 29712905 Nat Commun 2018 Apr 30 https://www.ncbi.nlm.nih.gov/pubmed/29712905
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates. Byrne EF, Luchetti G, Rohatgi R, Siebold C Current opinion in cell biology 29268141 Curr Opin Cell Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29268141
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R Developmental cell 24582806 Dev Cell 2014 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/24582806
Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X Molecular cell 29307513 Mol Cell 2018 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/29307513
Precision Optogenetic Tool for Selective Single- and Multiple-Cell Ablation in a Live Animal Model System. Makhijani K, To TL, Ruiz-González R, Lafaye C, Royant A, Shu X Cell chemical biology 28065655 Cell Chem Biol 2017 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/28065655
A rapid fluorogenic GPCR-β-arrestin interaction assay. Zhang Q, Zheng YW, Coughlin SR, Shu X Protein science : a publication of the Protein Society 29411438 Protein Sci 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29411438
Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach. Chung CI, Zhang Q, Shu X Analytical chemistry 30431263 Anal Chem 2018 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/30431263
Singlet oxygen triplet energy transfer-based imaging technology for mapping protein-protein proximity in intact cells. To TL, Fadul MJ, Shu X Nature communications 24905026 Nat Commun 2014 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/24905026
Photoactivatable protein labeling by singlet oxygen mediated reactions. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X Bioorganic & medicinal chemistry letters 27220724 Bioorg Med Chem Lett 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27220724
Structure-guided design of a reversible fluorogenic reporter of protein-protein interactions. To TL, Zhang Q, Shu X Protein science : a publication of the Protein Society 26690964 Protein Sci 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26690964
Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership. Mo CY, Culyba MJ, Selwood T, Kubiak JM, Hostetler ZM, Jurewicz AJ, Keller PM, Pope AJ, Quinn A, Schneck J, Widdowson KL, Kohli RM ACS infectious diseases 29275629 ACS Infect Dis 2018 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/29275629
Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network. Culyba MJ, Kubiak JM, Mo CY, Goulian M, Kohli RM PLoS genetics 29856734 PLoS Genet 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29856734
Targets for Combating the Evolution of Acquired Antibiotic Resistance. Culyba MJ, Mo CY, Kohli RM Biochemistry 26016604 Biochemistry 2015 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/26016604
Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response. Selwood T, Larsen BJ, Mo CY, Culyba MJ, Hostetler ZM, Kohli RM, Reitz AB, Baugh SDP Frontiers in microbiology 30619111 Front Microbiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30619111
Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics. Mo CY, Manning SA, Roggiani M, Culyba MJ, Samuels AN, Sniegowski PD, Goulian M, Kohli RM mSphere 27536734 mSphere 2016 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/27536734
A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage. Kubiak JM, Culyba MJ, Liu MY, Mo CY, Goulian M, Kohli RM ACS synthetic biology 28826208 ACS Synth Biol 2017 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/28826208
Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis. Mo CY, Birdwell LD, Kohli RM Biochemistry 24779472 Biochemistry 2014 May 20 https://www.ncbi.nlm.nih.gov/pubmed/24779472
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Fusion of dysfunction muscle stem cells with myofibers induces sarcopenia in mice. Wang X, Mishra P bioRxiv : the preprint server for biology 36711602 bioRxiv 2023 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/36711602
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis. Shelton SD, House S, Martins Nascentes Melo L, Ramesh V, Chen Z, Wei T, Wang X, Llamas CB, Venigalla SSK, Menezes CJ, Allies G, Krystkiewicz J, Rösler J, Meckelmann SW, Zhao P, Rambow F, Schadendorf D, Zhao Z, Gill JG, DeBerardinis RJ, Morrison SJ, Tasdogan A, Mishra P Science advances 39485847 Sci Adv 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39485847
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis. Shelton SD, House S, Ramesh V, Chen Z, Wei T, Wang X, Llamas CB, Venigalla SSK, Menezes CJ, Zhao Z, Gill JG, DeBerardinis RJ, Morrison SJ, Tasdogan A, Mishra P bioRxiv : the preprint server for biology 37732192 bioRxiv 2023 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/37732192
Lactate metabolism is essential in early-onset mitochondrial myopathy. Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P Science advances 36598990 Sci Adv 2023 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/36598990
Metabolic inflexibility promotes mitochondrial health during liver regeneration. Wang X, Menezes CJ, Jia Y, Xiao Y, Venigalla SSK, Cai F, Hsieh MH, Gu W, Du L, Sudderth J, Kim D, Shelton SD, Llamas CB, Lin YH, Zhu M, Merchant S, Bezwada D, Kelekar S, Zacharias LG, Mathews TP, Hoxhaj G, Wynn RM, Tambar UK, DeBerardinis RJ, Zhu H, Mishra P Science (New York, N.Y.) 38870309 Science 2024 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/38870309
Autosomal recessive progeroid syndrome due to homozygosity for a TOMM7 variant. Garg A, Keng WT, Chen Z, Sathe AA, Xing C, Kailasam PD, Shao Y, Lesner NP, Llamas CB, Agarwal AK, Mishra P The Journal of clinical investigation 36282599 J Clin Invest 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36282599
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy. Gok MO, Connor OM, Wang X, Menezes CJ, Llamas CB, Mishra P, Friedman JR The Journal of cell biology 36795401 J Cell Biol 2023 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/36795401
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Wang X, Shelton SD, Bordieanu B, Frank AR, Yi Y, Venigalla SSK, Gu Z, Lenser NP, Glogauer M, Chandel NS, Zhao H, Zhao Z, McFadden DG, Mishra P Nature aging 35342888 Nat Aging 2022 https://www.ncbi.nlm.nih.gov/pubmed/35342888
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle. Wang X, Jia Y, Zhao J, Lesner NP, Menezes CJ, Shelton SD, Venigalla SSK, Xu J, Cai C, Mishra P The Journal of clinical investigation 36125902 J Clin Invest 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36125902
Differential requirements for mitochondrial electron transport chain components in the adult murine liver. Lesner NP, Wang X, Chen Z, Frank A, Menezes CJ, House S, Shelton SD, Lemoff A, McFadden DG, Wansapura J, DeBerardinis RJ, Mishra P eLife 36154948 Elife 2022 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/36154948
Synthesis of push-pull-activated ynol ethers and their evaluation in the bioorthogonal hydroamination reaction. Kang D, Wahl C, Kim J Organic & biomolecular chemistry 36367436 Org Biomol Chem 2022 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/36367436
Bioorthogonally activated reactive species for target identification. Siriwongsup S, Schmoker AM, Ficarro SB, Marto JA, Kim J Chem 38617077 Chem 2024 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/38617077
Bioorthogonal Click and Release: A General, Rapid, Chemically Revertible Bioconjugation Strategy Employing Enamine N-oxides. Kang D, Lee S, Kim J Chem 36176744 Chem 2022 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/36176744
Bioorthogonal Hydroamination of Push-Pull-Activated Linear Alkynes. Kang D, Cheung ST, Kim J Angewandte Chemie (International ed. in English) 34019705 Angew Chem Int Ed Engl 2021 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/34019705
Bioorthogonal Retro-Cope Elimination Reaction of N,N-Dialkylhydroxylamines and Strained Alkynes. Kang D, Kim J Journal of the American Chemical Society 33829777 J Am Chem Soc 2021 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/33829777
Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents. Kang D, Cheung ST, Wong-Rolle A, Kim J ACS central science 34056093 ACS Cent Sci 2021 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/34056093
Enamine N-oxides: Design, Synthesis, and Function in Bioorthogonal Reactions. Kang D, Kim J Synlett : accounts and rapid communications in synthetic organic chemistry 38947226 Synlett 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38947226
Depolarization signatures map gold nanorods within biological tissue. Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE Nature photonics 29201136 Nat Photonics 2017 https://www.ncbi.nlm.nih.gov/pubmed/29201136
Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. Weng FJ, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M, Ku T, Zemoura K, Rich D, Garcia-Dominguez D, Hung M, Yelhekar TD, Sørensen AT, Xu W, Chung K, Castillo PE, Lin Y Neuron 29429933 Neuron 2018 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/29429933
Basic principles of hydrogel-based tissue transformation technologies and their applications. Choi SW, Guan W, Chung K Cell 34358468 Cell 2021 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/34358468
Multiscale 3D phenotyping of human cerebral organoids. Albanese A, Swaney JM, Yun DH, Evans NB, Antonucci JM, Velasco S, Sohn CH, Arlotta P, Gehrke L, Chung K Scientific reports 33293587 Sci Rep 2020 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/33293587
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH Cell 30879788 Cell 2019 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/30879788
Integrated platform for multiscale molecular imaging and phenotyping of the human brain. Park J, Wang J, Guan W, Gjesteby LA, Pollack D, Kamentsky L, Evans NB, Stirman J, Gu X, Zhao C, Marx S, Kim ME, Choi SW, Snyder M, Chavez D, Su-Arcaro C, Tian Y, Park CS, Zhang Q, Yun DH, Moukheiber M, Feng G, Yang XW, Keene CD, Hof PR, Ghosh SS, Frosch MP, Brattain LJ, Chung K Science (New York, N.Y.) 38870291 Science 2024 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/38870291
Self-organized developmental patterning and differentiation in cerebral organoids. Renner M, Lancaster MA, Bian S, Choi H, Ku T, Peer A, Chung K, Knoblich JA The EMBO journal 28283582 EMBO J 2017 May 15 https://www.ncbi.nlm.nih.gov/pubmed/28283582
Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions. Roy DS, Park YG, Kim ME, Zhang Y, Ogawa SK, DiNapoli N, Gu X, Cho JH, Choi H, Kamentsky L, Martin J, Mosto O, Aida T, Chung K, Tonegawa S Nature communications 35379803 Nat Commun 2022 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/35379803
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN Science translational medicine 28724577 Sci Transl Med 2017 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/28724577
Label-free volumetric optical imaging of intact murine brains. Ren J, Choi H, Chung K, Bouma BE Scientific reports 28401897 Sci Rep 2017 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/28401897
Elasticizing tissues for reversible shape transformation and accelerated molecular labeling. Ku T, Guan W, Evans NB, Sohn CH, Albanese A, Kim JG, Frosch MP, Chung K Nature methods 32424271 Nat Methods 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32424271
Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems. Murray E, Cho JH, Goodwin D, Ku T, Swaney J, Kim SY, Choi H, Park YG, Park JY, Hubbert A, McCue M, Vassallo S, Bakh N, Frosch MP, Wedeen VJ, Seung HS, Chung K Cell 26638076 Cell 2015 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/26638076
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. Ku T, Swaney J, Park JY, Albanese A, Murray E, Cho JH, Park YG, Mangena V, Chen J, Chung K Nature biotechnology 27454740 Nat Biotechnol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27454740
Protection of tissue physicochemical properties using polyfunctional crosslinkers. Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K Nature biotechnology 30556815 Nat Biotechnol 2018 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/30556815
TISSUE CLEARING. Richardson DS, Guan W, Matsumoto K, Pan C, Chung K, Ertürk A, Ueda HR, Lichtman JW Nature reviews. Methods primers 35128463 Nat Rev Methods Primers 2021 https://www.ncbi.nlm.nih.gov/pubmed/35128463
Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy. Mano T, Albanese A, Dodt HU, Erturk A, Gradinaru V, Treweek JB, Miyawaki A, Chung K, Ueda HR The Journal of neuroscience : the official journal of the Society for Neuroscience 30381424 J Neurosci 2018 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/30381424
Tissue clearing and its applications in neuroscience. Ueda HR, Ertürk A, Chung K, Gradinaru V, Chédotal A, Tomancak P, Keller PJ Nature reviews. Neuroscience 31896771 Nat Rev Neurosci 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31896771
Fetal and postnatal metal dysregulation in autism. Arora M, Reichenberg A, Willfors C, Austin C, Gennings C, Berggren S, Lichtenstein P, Anckarsäter H, Tammimies K, Bölte S Nature communications 28569757 Nat Commun 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28569757
Exposure to environmental chemical mixtures is associated with nasal colonization by Staphylococcus aureus: NHANES 2001-2004. Eggers S, Gennings C, Malecki KMC, Safdar N, Arora M Environmental research 32771801 Environ Res 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32771801
Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Austin C, Smith TM, Farahani RM, Hinde K, Carter EA, Lee J, Lay PA, Kennedy BJ, Sarrafpour B, Wright RJ, Wright RO, Arora M Scientific reports 26727334 Sci Rep 2016 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/26727334
Wintertime stress, nursing, and lead exposure in Neanderthal children. Smith TM, Austin C, Green DR, Joannes-Boyau R, Bailey S, Dumitriu D, Fallon S, Grün R, James HF, Moncel MH, Williams IS, Wood R, Arora M Science advances 30402544 Sci Adv 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30402544
Bayesian varying coefficient kernel machine regression to assess neurodevelopmental trajectories associated with exposure to complex mixtures. Liu SH, Bobb JF, Claus Henn B, Gennings C, Schnaas L, Tellez-Rojo M, Bellinger D, Arora M, Wright RO, Coull BA Statistics in medicine 30277584 Stat Med 2018 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/30277584
Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures. Liu SH, Bobb JF, Lee KH, Gennings C, Claus Henn B, Bellinger D, Austin C, Schnaas L, Tellez-Rojo MM, Hu H, Wright RO, Arora M, Coull BA Biostatistics (Oxford, England) 28968676 Biostatistics 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/28968676
Extending the Distributed Lag Model framework to handle chemical mixtures. Bello GA, Arora M, Austin C, Horton MK, Wright RO, Gennings C Environmental research 28371754 Environ Res 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28371754
Near-Infrared Intraoperative Chemiluminescence Imaging. Büchel GE, Carney B, Shaffer TM, Tang J, Austin C, Arora M, Zeglis BM, Grimm J, Eppinger J, Reiner T ChemMedChem 27471800 ChemMedChem 2016 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/27471800
Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives. Andra SS, Austin C, Yang J, Patel D, Arora M The Science of the total environment 27586167 Sci Total Environ 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27586167
Comparison of multiple X-ray fluorescence techniques for elemental analysis of particulate matter collected on air filters. Bilo F, Borgese L, Wambui A, Assi A, Zacco A, Federici S, Eichert DM, Tsuji K, Lucchini RG, Placidi D, Bontempi E, Depero LE Journal of aerosol science 30662085 J Aerosol Sci 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30662085
In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort. Cassidy-Bushrow AE, Wu KH, Sitarik AR, Park SK, Bielak LF, Austin C, Gennings C, Curtin P, Johnson CC, Arora M Environmental research 30735952 Environ Res 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30735952
Elemental signatures of Australopithecus africanus teeth reveal seasonal dietary stress. Joannes-Boyau R, Adams JW, Austin C, Arora M, Moffat I, Herries AIR, Tonge MP, Benazzi S, Evans AR, Kullmer O, Wroe S, Dosseto A, Fiorenza L Nature 31308534 Nature 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31308534
Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents. Chiu YM, Claus Henn B, Hsu HL, Pendo MP, Coull BA, Austin C, Cagna G, Fedrighi C, Placidi D, Smith DR, Wright RO, Lucchini RG, Arora M Environmental research 28858760 Environ Res 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28858760
Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities. Andra SS, Austin C, Arora M Environmental research 26219084 Environ Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26219084
Manganese in teeth and neurodevelopment in young Mexican-American children. Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B Environmental research 26381693 Environ Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26381693
Tooth manganese as a biomarker of exposure and body burden in rats. Austin C, Richardson C, Smith D, Arora M Environmental research 28279842 Environ Res 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28279842
Environmental exposures and pediatric kidney function and disease: A systematic review. Zheng LY, Sanders AP, Saland JM, Wright RO, Arora M Environmental research 28727988 Environ Res 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28727988
Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis. Curtin P, Austin C, Curtin A, Gennings C, Figueroa-Romero C, Mikhail KA, Botero TM, Goutman SA, Feldman EL, Arora M PLoS computational biology 32294079 PLoS Comput Biol 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32294079
Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice. Morris-Schaffer K, Sobolewski M, Allen JL, Marvin E, Yee M, Arora M, O'Reilly MA, Cory-Slechta DA Neurotoxicology 29920326 Neurotoxicology 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29920326
Early-life dentine manganese concentrations and intrinsic functional brain connectivity in adolescents: A pilot study. de Water E, Papazaharias DM, Ambrosi C, Mascaro L, Iannilli E, Gasparotti R, Lucchini RG, Austin C, Arora M, Tang CY, Smith DR, Wright RO, Horton MK PloS one 31412061 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/31412061
Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Curtin P, Austin C, Curtin A, Gennings C, Arora M, (for the Emergent Dynamical Systems Group), Tammimies K, Willfors C, Berggren S, Siper P, Rai D, Meyering K, Kolevzon A, Mollon J, David AS, Lewis G, Zammit S, Heilbrun L, Palmer RF, Wright RO, Bölte S, Reichenberg A Science advances 29854952 Sci Adv 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29854952
Stress exposure histories revealed by biochemical changes along accentuated lines in teeth. Austin C, Kumar P, Carter EA, Lee J, Smith TM, Hinde K, Arora M, Lay PA Chemosphere 37054846 Chemosphere 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37054846
Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry. Bauer JA, White RF, Coull BA, Austin C, Oppini M, Zoni S, Fedrighi C, Cagna G, Placidi D, Guazzetti S, Yang Q, Bellinger DC, Webster TF, Wright RO, Smith D, Horton M, Lucchini RG, Arora M, Claus Henn B Neurotoxicology 34478771 Neurotoxicology 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34478771
New Research Strategy for Measuring Pre- and Postnatal Metal Dysregulation in Psychotic Disorders. Velthorst E, Smith L, Bello G, Austin C, Gennings C, Modabbernia A, Franke N, Frangou S, Wright R, de Haan L, Reichenberg A, Arora M Schizophrenia bulletin 28981868 Schizophr Bull 2017 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/28981868
Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses. Claus Henn B, Austin C, Coull BA, Schnaas L, Gennings C, Horton MK, Hernández-Ávila M, Hu H, Téllez-Rojo MM, Wright RO, Arora M Environmental research 29247915 Environ Res 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29247915
A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers. Niedzwiecki MM, Austin C, Remark R, Merad M, Gnjatic S, Estrada-Gutierrez G, Espejel-Nuñez A, Borboa-Olivares H, Guzman-Huerta M, Wright RJ, Wright RO, Arora M Metallomics : integrated biometal science 26987553 Metallomics 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26987553
Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior. Horton MK, Hsu L, Claus Henn B, Margolis A, Austin C, Svensson K, Schnaas L, Gennings C, Hu H, Wright R, Rojo MMT, Arora M Environment international 30205321 Environ Int 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30205321
Cross-sectional study of the association between serum perfluorinated alkyl acid concentrations and dental caries among US adolescents (NHANES 1999-2012). Puttige Ramesh N, Arora M, Braun JM BMJ open 30782897 BMJ Open 2019 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/30782897
Is poor oral health a risk marker for incident cardiovascular disease hospitalisation and all-cause mortality? Findings from 172 630 participants from the prospective 45 and Up Study. Joshy G, Arora M, Korda RJ, Chalmers J, Banks E BMJ open 27577588 BMJ Open 2016 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/27577588
Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility. Bauer JA, Claus Henn B, Austin C, Zoni S, Fedrighi C, Cagna G, Placidi D, White RF, Yang Q, Coull BA, Smith D, Lucchini RG, Wright RO, Arora M Environment international 28941415 Environ Int 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28941415
Cyclical nursing patterns in wild orangutans. Smith TM, Austin C, Hinde K, Vogel ER, Arora M Science advances 28560319 Sci Adv 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28560319
Recurrence quantification analysis to characterize cyclical components of environmental elemental exposures during fetal and postnatal development. Curtin P, Curtin A, Austin C, Gennings C, Tammimies K, Bölte S, Arora M PloS one 29112980 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/29112980
Tooth-Matrix Biomarkers to Reconstruct Critical Periods of Brain Plasticity. Morishita H, Arora M Trends in neurosciences 28038829 Trends Neurosci 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/28038829
Multielemental bioimaging of tissues in children's environmental health research. Austinc C, Niedzwiecki MM, Arora M Current opinion in pediatrics 26845145 Curr Opin Pediatr 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26845145
Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome. Andra SS, Austin C, Wright RO, Arora M Environment international 26134987 Environ Int 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26134987
The tooth exposome in children's health research. Andra SS, Austin C, Arora M Current opinion in pediatrics 26859286 Curr Opin Pediatr 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26859286
Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernández-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B Environment international 26209874 Environ Int 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26209874
Burden of higher lead exposure in African-Americans starts in utero and persists into childhood. Cassidy-Bushrow AE, Sitarik AR, Havstad S, Park SK, Bielak LF, Austin C, Johnson CC, Arora M Environment international 28886415 Environ Int 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28886415
Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth. Wahlberg K, Arora M, Curtin A, Curtin P, Wright RO, Smith DR, Lucchini RG, Broberg K, Austin C Neurotoxicology 28917719 Neurotoxicology 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28917719
Manganese transporter genetics and sex modify the association between environmental manganese exposure and neurobehavioral outcomes in children. Broberg K, Taj T, Guazzetti S, Peli M, Cagna G, Pineda D, Placidi D, Wright RO, Smith DR, Lucchini RG, Wahlberg K Environment international 31233999 Environ Int 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31233999
Dynamical properties of elemental metabolism distinguish attention deficit hyperactivity disorder from autism spectrum disorder. Austin C, Curtin P, Curtin A, Gennings C, Arora M, Tammimies K, Isaksson J, Willfors C, Bölte S Translational psychiatry 31551411 Transl Psychiatry 2019 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/31551411
Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Liu SH, Bobb JF, Claus Henn B, Schnaas L, Tellez-Rojo MM, Gennings C, Arora M, Wright RO, Coull BA, Wand MP Environmetrics 30686915 Environmetrics 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/30686915
A Perspective on Crowdsourcing and Human-in-the-Loop Workflows in Precision Health. Washington P Journal of medical Internet research 38602750 J Med Internet Res 2024 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/38602750
Digitally Diagnosing Multiple Developmental Delays Using Crowdsourcing Fused With Machine Learning: Protocol for a Human-in-the-Loop Machine Learning Study. Jaiswal A, Kruiper R, Rasool A, Nandkeolyar A, Wall DP, Washington P JMIR research protocols 38329783 JMIR Res Protoc 2024 Feb 8 https://www.ncbi.nlm.nih.gov/pubmed/38329783
Audio-Based Emotion Recognition Using Self-Supervised Learning on an Engineered Feature Space. Nimitsurachat P, Washington P AI (Basel, Switzerland) 38715564 AI (Basel) 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38715564
Challenges in the Differential Classification of Individual Diagnoses from Co-Occurring Autism and ADHD Using Survey Data. Jaiswal A, Wall DP, Washington P ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics 40256615 IEEE EMBS Int Conf Biomed Health Inform 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/40256615
Soft mechanical sensors for wearable and implantable applications. Papani R, Li Y, Wang S Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 38723798 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2024 May-Jun https://www.ncbi.nlm.nih.gov/pubmed/38723798
Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design. Li Y, Li N, Liu W, Prominski A, Kang S, Dai Y, Liu Y, Hu H, Wai S, Dai S, Cheng Z, Su Q, Cheng P, Wei C, Jin L, Hubbell JA, Tian B, Wang S Nature communications 37495580 Nat Commun 2023 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/37495580
Bioadhesive polymer semiconductors and transistors for intimate biointerfaces. Li N, Li Y, Cheng Z, Liu Y, Dai Y, Kang S, Li S, Shan N, Wai S, Ziaja A, Wang Y, Strzalka J, Liu W, Zhang C, Gu X, Hubbell JA, Tian B, Wang S Science (New York, N.Y.) 37561870 Science 2023 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/37561870
Evaluation of Durability of Transparent Graphene Electrodes Fabricated on Different Flexible Substrates for Chronic In Vivo Experiments. Ding D, Lu Y, Zhao R, Liu X, De-Eknamkul C, Ren C, Mehrsa A, Komiyama T, Kuzum D IEEE transactions on bio-medical engineering 32191878 IEEE Trans Biomed Eng 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32191878
Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. Wilson MN, Thunemann M, Liu X, Lu Y, Puppo F, Adams JW, Kim JH, Ramezani M, Pizzo DP, Djurovic S, Andreassen OA, Mansour AA, Gage FH, Muotri AR, Devor A, Kuzum D Nature communications 36572698 Nat Commun 2022 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/36572698
E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies. Liu X, Terada S, Ramezani M, Kim JH, Lu Y, Grosmark A, Losonczy A, Kuzum D Cell reports 36198271 Cell Rep 2022 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/36198271
Energy-efficient Mott activation neuron for full-hardware implementation of neural networks. Oh S, Shi Y, Del Valle J, Salev P, Lu Y, Huang Z, Kalcheim Y, Schuller IK, Kuzum D Nature nanotechnology 33737724 Nat Nanotechnol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33737724
Innovating beyond electrophysiology through multimodal neural interfaces. Ramezani M, Ren Y, Cubukcu E, Kuzum D Nature reviews electrical engineering 40552318 Nat Rev Electr Eng 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/40552318
High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings. Ramezani M, Kim JH, Liu X, Ren C, Alothman A, De-Eknamkul C, Wilson MN, Cubukcu E, Gilja V, Komiyama T, Kuzum D Nature nanotechnology 38212523 Nat Nanotechnol 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38212523
Decoding of cortex-wide brain activity from local recordings of neural potentials. Liu X, Ren C, Huang Z, Wilson M, Kim JH, Lu Y, Ramezani M, Komiyama T, Kuzum D Journal of neural engineering 34706356 J Neural Eng 2021 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/34706356
Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical-hippocampal interactions. Liu X, Ren C, Lu Y, Liu Y, Kim JH, Leutgeb S, Komiyama T, Kuzum D Nature neuroscience 33875893 Nat Neurosci 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33875893
A Neuromorphic Brain Interface based on RRAM Crossbar Arrays for High Throughput Real-time Spike Sorting. Shi Y, Ananthakrishnan A, Oh S, Liu X, Hota G, Cauwenberghs G, Kuzum D IEEE transactions on electron devices 37168652 IEEE Trans Electron Devices 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/37168652
Microscale Physiological Events on the Human Cortical Surface. Paulk AC, Yang JC, Cleary DR, Soper DJ, Halgren M, O'Donnell AR, Lee SH, Ganji M, Ro YG, Oh H, Hossain L, Lee J, Tchoe Y, Rogers N, Kiliç K, Ryu SB, Lee SW, Hermiz J, Gilja V, Ulbert I, Fabó D, Thesen T, Doyle WK, Devinsky O, Madsen JR, Schomer DL, Eskandar EN, Lee JW, Maus D, Devor A, Fried SI, Jones PS, Nahed BV, Ben-Haim S, Bick SK, Richardson RM, Raslan AM, Siler DA, Cahill DP, Williams ZM, Cosgrove GR, Dayeh SA, Cash SS Cerebral cortex (New York, N.Y. : 1991) 33749727 Cereb Cortex 2021 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/33749727
Microscale dynamics of electrophysiological markers of epilepsy. Yang JC, Paulk AC, Salami P, Lee SH, Ganji M, Soper DJ, Cleary D, Simon M, Maus D, Lee JW, Nahed BV, Jones PS, Cahill DP, Cosgrove GR, Chu CJ, Williams Z, Halgren E, Dayeh S, Cash SS Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 34419344 Clin Neurophysiol 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34419344
Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks. Liu R, Lee J, Tchoe Y, Pre D, Bourhis AM, D'Antonio-Chronowska A, Robin G, Lee SH, Ro YG, Vatsyayan R, Tonsfeldt KJ, Hossain LA, Phipps ML, Yoo J, Nogan J, Martinez JS, Frazer KA, Bang AG, Dayeh SA Advanced functional materials 35603230 Adv Funct Mater 2022 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/35603230
Scalable tactile sensor arrays on flexible substrates with high spatiotemporal resolution enabling slip and grip for closed-loop robotics. Oh H, Yi GC, Yip M, Dayeh SA Science advances 33188031 Sci Adv 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33188031
Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces. Lee SH, Thunemann M, Lee K, Cleary DR, Tonsfeldt KJ, Oh H, Azzazy F, Tchoe Y, Bourhis AM, Hossain L, Ro YG, Tanaka A, Kılıç K, Devor A, Dayeh SA Advanced functional materials 36381629 Adv Funct Mater 2022 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/36381629
Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays. Russman SM, Cleary DR, Tchoe Y, Bourhis AM, Stedelin B, Martin J, Brown EC, Zhang X, Kawamoto A, Ryu WHA, Raslan AM, Ciacci JD, Dayeh SA Science translational medicine 36170445 Sci Transl Med 2022 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/36170445
Intraoperative application and early experience with novel high-resolution, high-channel-count thin-film electrodes for human microelectrocorticography. Tan H, Paulk AC, Stedelin B, Cleary DR, Nerison C, Tchoe Y, Brown EC, Bourhis A, Russman S, Lee J, Tonsfeldt KJ, Yang JC, Oh H, Ro YG, Lee K, Ganji M, Galton I, Siler D, Han SJ, Collins KL, Ben-Haim S, Halgren E, Cash SS, Dayeh S, Raslan AM Journal of neurosurgery 37874692 J Neurosurg 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/37874692
Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces. Vatsyayan R, Lee J, Bourhis AM, Tchoe Y, Cleary DR, Tonsfeldt KJ, Lee K, Montgomery-Walsh R, Paulk AC, U HS, Cash SS, Dayeh SA MRS bulletin 37476355 MRS Bull 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37476355
Flexible, scalable, high channel count stereo-electrode for recording in the human brain. Lee K, Paulk AC, Ro YG, Cleary DR, Tonsfeldt KJ, Kfir Y, Pezaris JS, Tchoe Y, Lee J, Bourhis AM, Vatsyayan R, Martin JR, Russman SM, Yang JC, Baohan A, Richardson RM, Williams ZM, Fried SI, Hoi Sang U, Raslan AM, Ben-Haim S, Halgren E, Cash SS, Dayeh SA Nature communications 38233418 Nat Commun 2024 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/38233418
Modular Phoneme Processing in Human Superior Temporal Gyrus. Cleary DR, Tchoe Y, Bourhis A, Dickey CW, Stedelin B, Ganji M, Lee SH, Lee J, Siler DA, Brown EC, Rosen BQ, Kaestner E, Yang JC, Soper DJ, Han SJ, Paulk AC, Cash SS, Raslan AMT, Dayeh SA, Halgren E bioRxiv : the preprint server for biology 38293030 bioRxiv 2024 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/38293030
Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics. Tchoe Y, Bourhis AM, Cleary DR, Stedelin B, Lee J, Tonsfeldt KJ, Brown EC, Siler DA, Paulk AC, Yang JC, Oh H, Ro YG, Lee K, Russman SM, Ganji M, Galton I, Ben-Haim S, Raslan AM, Dayeh SA Science translational medicine 35044788 Sci Transl Med 2022 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/35044788
An Analytical Model for Dual Gate Piezoelectrically Sensitive ZnO Thin Film Transistors. Oh H, Dayeh SA Advanced materials technologies 34485683 Adv Mater Technol 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34485683
Syllable processing is organized in discrete subregions of the human superior temporal gyrus. Cleary DR, Tchoe Y, Bourhis A, Dickey CW, Stedelin B, Ganji M, Lee SH, Lee J, Siler DA, Brown EC, Rosen BQ, Kaestner E, Yang JC, Soper DJ, Han SJ, Paulk AC, Cash SS, Raslan AM, Dayeh SA, Halgren E PLoS biology 39241107 PLoS Biol 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39241107
Surface-Grafted Biocompatible Polymer Conductors for Stable and Compliant Electrodes for Brain Interfaces. Blau R, Russman SM, Qie Y, Shipley W, Lim A, Chen AX, Nyayachavadi A, Ah L, Abdal A, Esparza GL, Edmunds SJ, Vatsyayan R, Dunfield SP, Halder M, Jokerst JV, Fenning DP, Tao AR, Dayeh SA, Lipomi DJ Advanced healthcare materials 39011811 Adv Healthc Mater 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39011811
Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces. Ganji M, Paulk AC, Yang JC, Vahidi NW, Lee SH, Liu R, Hossain L, Arneodo EM, Thunemann M, Shigyo M, Tanaka A, Ryu SB, Lee SW, Tchoe Y, Marsala M, Devor A, Cleary DR, Martin JR, Oh H, Gilja V, Gentner TQ, Fried SI, Halgren E, Cash SS, Dayeh SA Nano letters 31369283 Nano Lett 2019 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/31369283
Electrochemical safety limits for clinical stimulation investigated using depth and strip electrodes in the pig brain. Vatsyayan R, Cleary D, Martin JR, Halgren E, Dayeh SA Journal of neural engineering 34015769 J Neural Eng 2021 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/34015769
Considerations and recent advances in nanoscale interfaces with neuronal and cardiac networks. Tchoe Y, Lee J, Liu R, Bourhis AM, Vatsyayan R, Tonsfeldt KJ, Dayeh SA Applied physics reviews 34868443 Appl Phys Rev 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34868443
Spatially confined responses of mouse visual cortex to intracortical magnetic stimulation from micro-coils. Ryu SB, Paulk AC, Yang JC, Ganji M, Dayeh SA, Cash SS, Fried SI, Lee SW Journal of neural engineering 32998116 J Neural Eng 2020 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/32998116
Conductive electrospun polymer improves stem cell-derived cardiomyocyte function and maturation. Gonzalez G, Nelson AC, Holman AR, Whitehead AJ, LaMontagne E, Lian R, Vatsyayan R, Dayeh SA, Engler AJ Biomaterials 37898021 Biomaterials 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37898021
A Low-Noise Low-Power 0.001Hz-1kHz Neural Recording System-on-Chip With Sample-Level Duty-Cycling. Wu J, Akinin A, Somayajulu J, Lee MS, Paul A, Lu H, Park Y, Kim SJ, Mercier PP, Cauwenberghs G IEEE transactions on biomedical circuits and systems 38408002 IEEE Trans Biomed Circuits Syst 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38408002
An electroencephalogram microdisplay to visualize neuronal activity on the brain surface. Tchoe Y, Wu T, U HS, Roth DM, Kim D, Lee J, Cleary DR, Pizarro P, Tonsfeldt KJ, Lee K, Chen PC, Bourhis AM, Galton I, Coughlin B, Yang JC, Paulk AC, Halgren E, Cash SS, Dayeh SA Science translational medicine 38657026 Sci Transl Med 2024 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/38657026
The Brain Electroencephalogram Microdisplay for Precision Neurosurgery. Tchoe Y, Wu T, U HS, Roth DM, Kim D, Lee J, Cleary DR, Pizarro P, Tonsfeldt KJ, Lee K, Chen PC, Bourhis AM, Galton I, Coughlin B, Yang JC, Paulk AC, Halgren E, Cash SS, Dayeh SA bioRxiv : the preprint server for biology 37503216 bioRxiv 2023 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/37503216
A Comprehensive Large Signal, Small Signal, and Noise Model for IGZO Thin Film Transistor Circuits. Vatsyayan R, Dayeh SA IEEE transactions on electron devices 37680851 IEEE Trans Electron Devices 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37680851
Basics of Expansion Microscopy. Klimas A, Gallagher B, Zhao Y Current protocols in cytometry 31763769 Curr Protoc Cytom 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31763769
Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology. Bucur O, Fu F, Calderon M, Mylvaganam GH, Ly NL, Day J, Watkin S, Walker BD, Boyden ES, Zhao Y Nature protocols 32238952 Nat Protoc 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32238952
Expansion microscopy: A powerful nanoscale imaging tool for neuroscientists. Gallagher BR, Zhao Y Neurobiology of disease 33813047 Neurobiol Dis 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33813047
Expansion Microscopy: Toward Nanoscale Imaging of a Diverse Range of Biomolecules. Klimas A, Zhao Y ACS nano 32628828 ACS Nano 2020 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/32628828
MicroMagnify: A Multiplexed Expansion Microscopy Method for Pathogens and Infected Tissues. Cheng Z, Stefani C, Skillman T, Klimas A, Lee A, DiBernardo EF, Brown KM, Milman T, Wang Y, Gallagher BR, Lagree K, Jena BP, Pulido JS, Filler SG, Mitchell AP, Hiller NL, Lacy-Hulbert A, Zhao Y Advanced science (Weinheim, Baden-Wurttemberg, Germany) 37658522 Adv Sci (Weinh) 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37658522
Magnify is a universal molecular anchoring strategy for expansion microscopy. Klimas A, Gallagher BR, Wijesekara P, Fekir S, DiBernardo EF, Cheng Z, Stolz DB, Cambi F, Watkins SC, Brody SL, Horani A, Barth AL, Moore CI, Ren X, Zhao Y Nature biotechnology 36593399 Nat Biotechnol 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/36593399
Super-Resolution Vibrational Imaging Using Expansion Stimulated Raman Scattering Microscopy. Shi L, Klimas A, Gallagher B, Cheng Z, Fu F, Wijesekara P, Miao Y, Ren X, Zhao Y, Min W Advanced science (Weinheim, Baden-Wurttemberg, Germany) 35521971 Adv Sci (Weinh) 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35521971
A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function. Pinckard KM, Shettigar VK, Wright KR, Abay E, Baer LA, Vidal P, Dewal RS, Das D, Duarte-Sanmiguel S, Hernández-Saavedra D, Arts PJ, Lehnig AC, Bussberg V, Narain NR, Kiebish MA, Yi F, Sparks LM, Goodpaster BH, Smith SR, Pratley RE, Lewandowski ED, Raman SV, Wold LE, Gallego-Perez D, Coen PM, Ziolo MT, Stanford KI Circulation 33106031 Circulation 2021 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/33106031
Nanotransfection-based vasculogenic cell reprogramming drives functional recovery in a mouse model of ischemic stroke. Lemmerman LR, Balch MHH, Moore JT, Alzate-Correa D, Rincon-Benavides MA, Salazar-Puerta A, Gnyawali S, Harris HN, Lawrence W, Ortega-Pineda L, Wilch L, Risser IB, Maxwell AJ, Duarte-Sanmiguel S, Dodd D, Guio-Vega GP, McTigue DM, Arnold WD, Nimjee SM, Sen CK, Khanna S, Rink C, Higuita-Castro N, Gallego-Perez D Science advances 33741587 Sci Adv 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33741587
Injectable pulverized electrospun poly(lactic-co-glycolic acid) fibers improve human adipose tissue engraftment and volume retention. Das D, Lawrence WR, Diaz-Starokozheva L, Salazar-Puerta AI, Ott N, Goebel ER, Damughatla A, Vidal P, Gallentine S, Moore JT, Kayuha D, Mendonca NC, Albert JB, Houser R, Johnson J, Powell H, Higuita-Castro N, Stanford KI, Gallego-Perez D Journal of biomedical materials research. Part A 37326365 J Biomed Mater Res A 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37326365
Engineered extracellular vesicles from human skin cells induce pro-β-cell conversions in pancreatic ductal cells. Ortega-Pineda L, Guilfoyle E, Rincon-Benavides MA, Anaparthi AL, Lemmerman LR, Cuellar-Gaviria TZ, Lawrence W, Buss JL, Deng B, Blackstone BN, Salazar-Puerta A, McComb DW, Powell H, Gallego-Perez D, Higuita-Castro N Advanced nanobiomed research 38911285 Adv Nanobiomed Res 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/38911285
Tissue nano-transfection of antimicrobial genes drives bacterial biofilm killing in wounds and is potentially mediated by extracellular vesicles. Cuellar-Gaviria TZ, Rincon-Benavides MA, Halipci Topsakal HN, Salazar-Puerta AI, Jaramillo-Garrido S, Kordowski M, Vasquez-Martinez CA, Nguyen KT, Rima XY, Rana PSJB, Combita-Heredia O, Deng B, Dathathreya K, McComb DW, Reategui E, Wozniak D, Higuita-Castro N, Gallego-Perez D Journal of controlled release : official journal of the Controlled Release Society 39491627 J Control Release 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39491627
The Fifth Annual Symposium of the Midwest Aging Consortium. Reader BF, Rosas L, Knopf BA, Liu Y, Alzate-Correa D, Bhat A, Carey A, Cuervo AM, Dayal S, Demarco RS, Elliehausen CJ, Englund DA, Hamilton HL, Johnston M, Kang P, Konopka AR, Lepola N, Presley CJ, Schafer MJ, Serrano J, Singer BD, Song MA, Stanford KI, Taylor J, Wei W, Yeh CY, Zhang L, Zhang L, Anderson RM, Bai H, Robbins PD, Lamming DW, Mihaylova MM, Rojas M, Mora AL The journals of gerontology. Series A, Biological sciences and medical sciences 39704343 J Gerontol A Biol Sci Med Sci 2025 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/39704343
Engineered Extracellular Vesicle-Based Therapies for Valvular Heart Disease. Salazar-Puerta AI, Kordowski M, Cuellar-Gaviria TZ, Rincon-Benavides MA, Hussein J, Flemister D, Mayoral-Andrade G, Barringer G, Guilfoyle E, Blackstone BN, Deng B, Zepeda-Orozco D, McComb DW, Powell H, Dasi LP, Gallego-Perez D, Higuita-Castro N Cellular and molecular bioengineering 37810997 Cell Mol Bioeng 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37810997
Nanotechnology-Driven Cell-Based Therapies in Regenerative Medicine. Alzate-Correa D, Lawrence WR, Salazar-Puerta A, Higuita-Castro N, Gallego-Perez D The AAPS journal.. 35292878 AAPS J 2022 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/35292878
Transient Middle Cerebral Artery Occlusion with an Intraluminal Suture Enables Reproducible Induction of Ischemic Stroke in Mice. Lemmerman LR, Harris HN, Balch MHH, Rincon-Benavides MA, Higuita-Castro N, Arnold DW, Gallego-Perez D Bio-protocol 35284595 Bio Protoc 2022 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/35284595
Early Intervention in Ischemic Tissue with Oxygen Nanocarriers Enables Successful Implementation of Restorative Cell Therapies. Diaz-Starokozheva L, Das D, Gu X, Moore JT, Lemmerman LR, Valerio I, Powell HM, Higuita-Castro N, Go MR, Palmer AF, Gallego-Perez D Cellular and molecular bioengineering 33184576 Cell Mol Bioeng 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33184576
Nanochannel-Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue. Moore JT, Wier CG, Lemmerman LR, Ortega-Pineda L, Dodd DJ, Lawrence WR, Duarte-Sanmiguel S, Dathathreya K, Diaz-Starokozheva L, Harris HN, Sen CK, Valerio IL, Higuita-Castro N, Arnold WD, Kolb SJ, Gallego-Perez D Advanced biosystems 32939985 Adv Biosyst 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32939985
Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment. Lemmerman LR, Das D, Higuita-Castro N, Mirmira RG, Gallego-Perez D Trends in endocrinology and metabolism: TEM 32396845 Trends Endocrinol Metab 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32396845
Reciprocal Signaling between Myeloid Derived Suppressor and Tumor Cells Enhances Cellular Motility and is Mediated by Structural Cues in the Microenvironment. Shukla VC, Duarte-Sanmiguel S, Panic A, Senthilvelan A, Moore J, Bobba C, Benner B, Carson WE 3rd, Ghadiali SN, Gallego-Perez D Advanced biosystems 32419350 Adv Biosyst 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32419350
Designer Extracellular Vesicles Modulate Pro-Neuronal Cell Responses and Improve Intracranial Retention. Ortega-Pineda L, Sunyecz A, Salazar-Puerta AI, Rincon-Benavides MA, Alzate-Correa D, Anaparthi AL, Guilfoyle E, Mezache L, Struckman HL, Duarte-Sanmiguel S, Deng B, McComb DW, Dodd DJ, Lawrence WR, Moore J, Zhang J, Reátegui E, Veeraraghavan R, Nelson MT, Gallego-Perez D, Higuita-Castro N Advanced healthcare materials 35014204 Adv Healthc Mater 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35014204
In Situ Deployment of Engineered Extracellular Vesicles into the Tumor Niche via Myeloid-Derived Suppressor Cells. Duarte-Sanmiguel S, Panic A, Dodd DJ, Salazar-Puerta A, Moore JT, Lawrence WR, Nairon K, Francis C, Zachariah N, McCoy W, Turaga R, Skardal A, Carson WE, Higuita-Castro N, Gallego-Perez D Advanced healthcare materials 34662497 Adv Healthc Mater 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34662497
Engineered Vasculogenic Extracellular Vesicles Drive Nonviral Direct Conversions of Human Dermal Fibroblasts into Induced Endothelial Cells and Improve Wound Closure. Rincon-Benavides MA, Mendonca NC, Cuellar-Gaviria TZ, Salazar-Puerta AI, Ortega-Pineda L, Blackstone BN, Deng B, McComb DW, Gallego-Perez D, Powell HM, Higuita-Castro N Advanced therapeutics 37577183 Adv Ther (Weinh) 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/37577183
Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury. Salazar-Puerta AI, Rincon-Benavides MA, Cuellar-Gaviria TZ, Aldana J, Vasquez Martinez G, Ortega-Pineda L, Das D, Dodd D, Spencer CA, Deng B, McComb DW, Englert JA, Ghadiali S, Zepeda-Orozco D, Wold LE, Gallego-Perez D, Higuita-Castro N Advanced materials (Deerfield Beach, Fla.) 37119468 Adv Mater 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37119468
Guided migration analyses at the single-clone level uncover cellular targets of interest in tumor-associated myeloid-derived suppressor cell populations. Duarte-Sanmiguel S, Shukla V, Benner B, Moore J, Lemmerman L, Lawrence W, Panic A, Wang S, Idzkowski N, Guio-Vega G, Higuita-Castro N, Ghadiali S, Carson WE, Gallego-Perez D Scientific reports 31988310 Sci Rep 2020 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/31988310
ICAM-1-decorated extracellular vesicles loaded with miR-146a and Glut1 drive immunomodulation and hinder tumor progression in a murine model of breast cancer. Duarte-Sanmiguel S, Salazar-Puerta AI, Panic A, Dodd D, Francis C, Alzate-Correa D, Ortega-Pineda L, Lemmerman L, Rincon-Benavides MA, Dathathreya K, Lawrence W, Ott N, Zhang J, Deng B, Wang S, Santander SP, McComb DW, Reategui E, Palmer AF, Carson WE, Higuita-Castro N, Gallego-Perez D Biomaterials science 37646133 Biomater Sci 2023 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/37646133
Self-assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics. Desai P, Venkataramanan A, Schneider R, Jaiswal MK, Carrow JK, Purwada A, Singh A, Gaharwar AK Journal of biomedical materials research. Part A 29577576 J Biomed Mater Res A 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29577576
3D Bioprinted Multicellular Vascular Models. Gold KA, Saha B, Rajeeva Pandian NK, Walther BK, Palma JA, Jo J, Cooke JP, Jain A, Gaharwar AK Advanced healthcare materials 34310082 Adv Healthc Mater 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34310082
Nanoengineered Colloidal Inks for 3D Bioprinting. Peak CW, Stein J, Gold KA, Gaharwar AK Langmuir : the ACS journal of surfaces and colloids 28981287 Langmuir 2018 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/28981287
Photothermal modulation of human stem cells using light-responsive 2D nanomaterials. Carrow JK, Singh KA, Jaiswal MK, Ramirez A, Lokhande G, Yeh AT, Sarkar TR, Singh I, Gaharwar AK Proceedings of the National Academy of Sciences of the United States of America 32461372 Proc Natl Acad Sci U S A 2020 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/32461372
Conditioning of 3D Printed Nanoengineered Ionic-Covalent Entanglement Scaffolds with iP-hMSCs Derived Matrix. Sears C, Mondragon E, Richards ZI, Sears N, Chimene D, McNeill EP, Gregory CA, Gaharwar AK, Kaunas R Advanced healthcare materials 32147960 Adv Healthc Mater 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32147960
Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates. Cross LM, Carrow JK, Ding X, Singh KA, Gaharwar AK ACS applied materials & interfaces 30676016 ACS Appl Mater Interfaces 2019 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/30676016
Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion. Jaiswal MK , Singh KA , Lokhande G , Gaharwar AK Chemical communications (Cambridge, England) 31172998 Chem Commun (Camb) 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31172998
Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips. Mathur T, Singh KA, R Pandian NK, Tsai SH, Hein TW, Gaharwar AK, Flanagan JM, Jain A Lab on a chip 31246211 Lab Chip 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31246211
Comparison of Photo Cross Linkable Gelatin Derivatives and Initiators for Three-Dimensional Extrusion Bioprinting. Tigner TJ, Rajput S, Gaharwar AK, Alge DL Biomacromolecules 31743018 Biomacromolecules 2020 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/31743018
Animal models of postpartum hemorrhage. Hargett SE, Leslie EF, Chapa HO, Gaharwar AK Lab animal 38528231 Lab Anim (NY) 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38528231
Nanobio Interface Between Proteins and 2D Nanomaterials. Roy S, Aastha, Deo KA, Dey K, Gaharwar AK, Jaiswal A ACS applied materials & interfaces 37487195 ACS Appl Mater Interfaces 2023 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/37487195
Dynamically crosslinked thermoresponsive granular hydrogels. Lee HP, Cai KX, Wang TC, Davis R Jr, Deo K, Singh KA, Lele TP, Gaharwar AK Journal of biomedical materials research. Part A 37199446 J Biomed Mater Res A 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37199446
Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue. Chimene D, Miller L, Cross LM, Jaiswal MK, Singh I, Gaharwar AK ACS applied materials & interfaces 32091189 ACS Appl Mater Interfaces 2020 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/32091189
Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program. Brokesh AM, Cross LM, Kersey AL, Murali A, Richter C, Gregory CA, Singh I, Gaharwar AK Science advances 35476448 Sci Adv 2022 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/35476448
Gradient nanocomposite hydrogels for interface tissue engineering. Cross LM, Shah K, Palani S, Peak CW, Gaharwar AK Nanomedicine : nanotechnology, biology, and medicine 28554596 Nanomedicine 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/28554596
Light-Responsive Inorganic Biomaterials for Biomedical Applications. Lee HP, Gaharwar AK Advanced science (Weinheim, Baden-Wurttemberg, Germany) 32995121 Adv Sci (Weinh) 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32995121
Inorganic ions activate lineage-specific gene regulatory networks. Kersey AL, Singh I, Gaharwar AK Acta biomaterialia 38552761 Acta Biomater 2024 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/38552761
Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis. Singh KA, Soukar J, Zulkifli M, Kersey A, Lokhande G, Ghosh S, Murali A, Garza NM, Kaur H, Keeney JN, Banavath R, Ceylan Koydemir H, Sitcheran R, Singh I, Gohil VM, Gaharwar AK Nature communications 39289340 Nat Commun 2024 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/39289340
Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation. Murali A, Brokesh AM, Cross LM, Kersey AL, Jaiswal MK, Singh I, Gaharwar A Advanced science (Weinheim, Baden-Wurttemberg, Germany) 38738803 Adv Sci (Weinh) 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38738803
Organelle-Targeting Nanoparticles. Soukar J, Peppas NA, Gaharwar AK Advanced science (Weinheim, Baden-Wurttemberg, Germany) 39806939 Adv Sci (Weinh) 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39806939
Effect of ionic strength on shear-thinning nanoclay-polymer composite hydrogels. Sheikhi A , Afewerki S , Oklu R , Gaharwar AK , Khademhosseini A Biomaterials science 29944151 Biomater Sci 2018 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/29944151
Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration. Peak CW, Singh KA, Adlouni M, Chen J, Gaharwar AK Advanced healthcare materials 31066517 Adv Healthc Mater 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31066517
3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering. Carrow JK, Di Luca A, Dolatshahi-Pirouz A, Moroni L, Gaharwar AK Regenerative biomaterials 30740240 Regen Biomater 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30740240
Emerging 2D Nanomaterials for Biomedical Applications. Murali A, Lokhande G, Deo KA, Brokesh A, Gaharwar AK Materials today (Kidlington, England) 34970073 Mater Today (Kidlington) 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34970073
Polymer-Coated Extracellular Vesicles for Selective Codelivery of Chemotherapeutics and siRNA to Cancer Cells. Jhan YY, Palou Zuniga G, Singh KA, Gaharwar AK, Alge DL, Bishop CJ ACS applied bio materials 35014481 ACS Appl Bio Mater 2021 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/35014481
Nanoengineered Ink for Designing 3D Printable Flexible Bioelectronics. Deo KA, Jaiswal MK, Abasi S, Lokhande G, Bhunia S, Nguyen TU, Namkoong M, Darvesh K, Guiseppi-Elie A, Tian L, Gaharwar AK ACS nano 35675588 ACS Nano 2022 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/35675588
Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting. Xin S , Chimene D , Garza JE , Gaharwar AK , Alge DL Biomaterials science 30656307 Biomater Sci 2019 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/30656307
Nano-bio interactions of 2D molybdenum disulfide. Roy S, Deo KA, Singh KA, Lee HP, Jaiswal A, Gaharwar AK Advanced drug delivery reviews 35636569 Adv Drug Deliv Rev 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35636569
2D layered nanomaterials for therapeutics delivery. Davis R Jr, Urbanowski RA Jr, Gaharwar AK Current opinion in biomedical engineering 35814330 Curr Opin Biomed Eng 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/35814330
2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells. Bhunia S, Jaiswal MK, Singh KA, Deo KA, Gaharwar AK Advanced healthcare materials 35104392 Adv Healthc Mater 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35104392
Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting. Xin S, Deo KA, Dai J, Pandian NKR, Chimene D, Moebius RM, Jain A, Han A, Gaharwar AK, Alge DL Science advances 34652944 Sci Adv 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34652944
Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing. Gold K, Gaharwar AK, Jain A Biomaterials 30072038 Biomaterials 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30072038
2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing. Gaharwar AK, Cross LM, Peak CW, Gold K, Carrow JK, Brokesh A, Singh KA Advanced materials (Deerfield Beach, Fla.) 30941811 Adv Mater 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30941811
Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders. Erezuma I, Eufrasio-da-Silva T, Golafshan N, Deo K, Mishra YK, Castilho M, Gaharwar AK, Leeuwenburgh S, Dolatshahi-Pirouz A, Orive G Advanced healthcare materials 34185438 Adv Healthc Mater 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34185438
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting. Deo KA, Murali A, Tronolone JJ, Mandrona C, Lee HP, Rajput S, Hargett SE, Selahi A, Sun Y, Alge DL, Jain A, Gaharwar AK Advanced healthcare materials 38749006 Adv Healthc Mater 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38749006
Intra-Articular Injectable Biomaterials for Cartilage Repair and Regeneration. Kalairaj MS, Pradhan R, Saleem W, Smith MM, Gaharwar AK Advanced healthcare materials 38324655 Adv Healthc Mater 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38324655
Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery. Lee HP, Davis R Jr, Wang TC, Deo KA, Cai KX, Alge DL, Lele TP, Gaharwar AK ACS applied bio materials 37584641 ACS Appl Bio Mater 2023 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/37584641
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs. Kersey AL, Cheng DY, Deo KA, Dubell CR, Wang TC, Jaiswal MK, Kim MH, Murali A, Hargett SE, Mallick S, Lele TP, Singh I, Gaharwar AK Biomaterials 38335719 Biomaterials 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38335719
Screening a chemically defined extracellular matrix mimetic substrate library to identify substrates that enhance substrate-mediated transfection. Hamann A, Thomas AK, Kozisek T, Farris E, Lück S, Zhang Y, Pannier AK Experimental biology and medicine (Maywood, N.J.) 32183552 Exp Biol Med (Maywood) 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32183552
Formulation of Chitosan-Zein Nano-in-Microparticles for Oral DNA Delivery. Heck K, Farris E, Pannier AK Methods in molecular biology (Clifton, N.J.) 37775665 Methods Mol Biol 2024 https://www.ncbi.nlm.nih.gov/pubmed/37775665
Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications. Hamann A, Nguyen A, Pannier AK Journal of biological engineering 30675180 J Biol Eng 2019 https://www.ncbi.nlm.nih.gov/pubmed/30675180
High- and low-molecular-weight chitosan act as adjuvants during single-dose influenza A virus protein vaccination through distinct mechanisms. Lampe AT, Farris EJ, Brown DM, Pannier AK Biotechnology and bioengineering 33289090 Biotechnol Bioeng 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33289090
Glucocorticoid Priming of Nonviral Gene Delivery to hMSCs Increases Transfection by Reducing Induced Stresses. Hamann A, Kozisek T, Broad K, Pannier AK Molecular therapy. Methods & clinical development 32913879 Mol Ther Methods Clin Dev 2020 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/32913879
High-throughput screening of clinically approved drugs that prime nonviral gene delivery to human Mesenchymal stem cells. Kozisek T, Hamann A, Nguyen A, Miller M, Plautz S, Pannier AK Journal of biological engineering 32467728 J Biol Eng 2020 https://www.ncbi.nlm.nih.gov/pubmed/32467728
Mechanisms of unprimed and dexamethasone-primed nonviral gene delivery to human mesenchymal stem cells. Hamann A, Broad K, Nguyen A, Pannier AK Biotechnology and bioengineering 30450542 Biotechnol Bioeng 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30450542
Oral Non-Viral Gene Delivery for Applications in DNA Vaccination and Gene Therapy. Farris E, Sanderfer K, Lampe A, Brown DM, Ramer-Tait AE, Pannier AK Current opinion in biomedical engineering 31011691 Curr Opin Biomed Eng 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/31011691
Systematic comparison of nonviral gene delivery strategies for efficient co-expression of two transgenes in human mesenchymal stem cells. Kozisek T, Samuelson L, Hamann A, Pannier AK Journal of biological engineering 38062439 J Biol Eng 2023 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/38062439
Free Polyethylenimine Enhances Substrate-Mediated Gene Delivery on Titanium Substrates Modified With RGD-Functionalized Poly(acrylic acid) Brushes. Mantz A, Rosenthal A, Farris E, Kozisek T, Bittrich E, Nazari S, Schubert E, Schubert M, Stamm M, Uhlmann P, Pannier AK Frontiers in chemistry 30792979 Front Chem 2019 https://www.ncbi.nlm.nih.gov/pubmed/30792979
Surface- and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles. Pannier AK, Kozisek T, Segura T Methods in molecular biology (Clifton, N.J.) 30838617 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/30838617
Combined TLR4 and TLR9 agonists induce distinct phenotypic changes in innate immunity in vitro and in vivo. Lampe AT, Puniya BL, Pannier AK, Helikar T, Brown DM Cellular immunology 32619809 Cell Immunol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32619809
Innovative nonviral gene delivery strategies for engineering human mesenchymal stem cell phenotypes toward clinical applications. Hamann A, Pannier AK Current opinion in biotechnology 36274497 Curr Opin Biotechnol 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36274497
Comparison of promoter, DNA vector, and cationic carrier for efficient transfection of hMSCs from multiple donors and tissue sources. Kozisek T, Hamann A, Samuelson L, Fudolig M, Pannier AK Molecular therapy. Nucleic acids 34513295 Mol Ther Nucleic Acids 2021 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/34513295
Biomaterial substrate modifications that influence cell-material interactions to prime cellular responses to nonviral gene delivery. Mantz A, Pannier AK Experimental biology and medicine (Maywood, N.J.) 30621454 Exp Biol Med (Maywood) 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30621454
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Nanoscale partitioning of paclitaxel in hybrid lipid-polymer membranes. Tuteja M , Kang M , Leal C , Centrone A The Analyst 29878001 Analyst 2018 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/29878001
Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion. Koo J, Kim SB, Choi YS, Xie Z, Bandodkar AJ, Khalifeh J, Yan Y, Kim H, Pezhouh MK, Doty K, Lee G, Chen YY, Lee SM, D'Andrea D, Jung K, Lee K, Li K, Jo S, Wang H, Kim JH, Kim J, Choi SG, Jang WJ, Oh YS, Park I, Kwak SS, Park JH, Hong D, Feng X, Lee CH, Banks A, Leal C, Lee HM, Huang Y, Franz CK, Ray WZ, MacEwan M, Kang SK, Rogers JA Science advances 32923633 Sci Adv 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32923633
Open-air synthesis of oligo(ethylene glycol)-functionalized polypeptides from non-purified N-carboxyanhydrides. Tan Z, Song Z, Xue T, Zheng L, Jiang L, Jiang Y, Fu Z, Nguyen A, Leal C, Cheng J Biomaterials science 33949455 Biomater Sci 2021 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/33949455
Microfluidics Synthesis of Gene Silencing Cubosomes. Kim H, Sung J, Chang Y, Alfeche A, Leal C ACS nano 30081623 ACS Nano 2018 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/30081623
Self-organization of Nucleic Acids in Lipid Constructs. Kang M, Kim H, Leal C Current opinion in colloid & interface science 28496379 Curr Opin Colloid Interface Sci 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/28496379
Thermally Functional Liquid Crystal Networks by Magnetic Field Driven Molecular Orientation. Shin J, Kang M, Tsai T, Leal C, Braun PV, Cahill DG ACS macro letters 35607211 ACS Macro Lett 2016 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/35607211
Lipid-based Liquid Crystalline Films and Solutions for the Delivery of Cargo to Cells. Porras-Gomez M, Leal C Liquid crystals reviews 31942262 Liq Cryst Rev 2019 https://www.ncbi.nlm.nih.gov/pubmed/31942262
Three-Dimensional Microphase Separation and Synergistic Permeability in Stacked Lipid-Polymer Hybrid Membranes. Kang M, Lee B, Leal C Chemistry of materials : a publication of the American Chemical Society 31097879 Chem Mater 2017 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/31097879
Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm. Zheng L, Bandara SR, Tan Z, Leal C Proceedings of the National Academy of Sciences of the United States of America 37364130 Proc Natl Acad Sci U S A 2023 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/37364130
Polymer-Lipid Hybrid Materials. Go YK, Leal C Chemical reviews 34752064 Chem Rev 2021 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/34752064
Graphene-based sensing of oxygen transport through pulmonary membranes. Kim M, Porras-Gomez M, Leal C Nature communications 32107376 Nat Commun 2020 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/32107376
Near-Infrared-Triggered Reversible Transformations of Gold Nanorod-Laden Lipid Assemblies: Implications for Cellular Delivery. Rueben J, Jayaraman A, Mahanthappa MK, Leal C ACS applied nano materials 40115494 ACS Appl Nano Mater 2022 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/40115494
Hybrid Unilamellar Vesicles of Phospholipids and Block Copolymers with Crystalline Domains. Go YK, Kambar N, Leal C Polymers 32485809 Polymers (Basel) 2020 May 29 https://www.ncbi.nlm.nih.gov/pubmed/32485809
The stabilization of primitive bicontinuous cubic phases with tunable swelling over a wide composition range. Leung SSW , Leal C Soft matter 30462135 Soft Matter 2019 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/30462135
Nanostructured Lipid-based Films for Substrate Mediated Applications in Biotechnology. Kang M, Tuteja M, Centrone A, Topgaard D, Leal C Advanced functional materials 31080383 Adv Funct Mater 2018 https://www.ncbi.nlm.nih.gov/pubmed/31080383
The structural fate of lipid nanoparticles in the extracellular matrix. Bandara SR, Molley TG, Kim H, Bharath PA, Kilian KA, Leal C Materials horizons 31942243 Mater Horiz 2020 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/31942243
3D Columnar Phase of Stacked Short DNA Organized by Coherent Membrane Undulations. Bouxsein NF, Leal C, McAllister CS, Li Y, Ewert KK, Samuel CE, Safinya CR Langmuir : the ACS journal of surfaces and colloids 31408350 Langmuir 2019 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/31408350
Optogenetic Reconstitution for Determining the Form and Function of Membraneless Organelles. Dine E, Toettcher JE Biochemistry 29373016 Biochemistry 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29373016
Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Zhao EM, Zhang Y, Mehl J, Park H, Lalwani MA, Toettcher JE, Avalos JL Nature 29562237 Nature 2018 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/29562237
Engineering combinatorial and dynamic decoders using synthetic immediate-early genes. Ravindran PT, Wilson MZ, Jena SG, Toettcher JE Communications biology 32792645 Commun Biol 2020 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/32792645
Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. Iuliano JN, Collado JT, Gil AA, Ravindran PT, Lukacs A, Shin S, Woroniecka HA, Adamczyk K, Aramini JM, Edupuganti UR, Hall CR, Greetham GM, Sazanovich IV, Clark IP, Daryaee T, Toettcher JE, French JB, Gardner KH, Simmerling CL, Meech SR, Tonge PJ ACS chemical biology 32880430 ACS Chem Biol 2020 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/32880430
A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Goglia AG, Wilson MZ, Jena SG, Silbert J, Basta LP, Devenport D, Toettcher JE Cell systems 32191874 Cell Syst 2020 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/32191874
A synthetic gene circuit for imaging-free detection of signaling pulses. Ravindran PT, McFann S, Thornton RH, Toettcher JE Cell systems 34739875 Cell Syst 2022 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/34739875
Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Wilson MZ, Ravindran PT, Lim WA, Toettcher JE Molecular cell 28826673 Mol Cell 2017 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/28826673
Erratum: Publisher Correction: Deconstructing and repurposing the light-regulated interplay between Arabidopsis phytochromes and interacting factors. Golonka D, Fischbach P, Jena SG, Kleeberg JRW, Essen LO, Toettcher JE, Zurbriggen MD, Möglich A Communications biology 31872077 Commun Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31872077
Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Goglia AG, Wilson MZ, DiGiorno DB, Toettcher JE Methods in molecular biology (Clifton, N.J.) 28730469 Methods Mol Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28730469
Membrane-proximal motifs encode differences in signaling strength between type I and III interferon receptors. Mesev EV, Lin AE, Guare EG, Heller BL, Douam F, Adamson B, Toettcher JE, Ploss A Science signaling 37816090 Sci Signal 2023 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/37816090
Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds. Bracha D, Walls MT, Wei MT, Zhu L, Kurian M, Avalos JL, Toettcher JE, Brangwynne CP Cell 30500534 Cell 2018 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/30500534
A size-invariant bud-duration timer enables robustness in yeast cell size control. Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR PloS one 30576342 PLoS One 2018 https://www.ncbi.nlm.nih.gov/pubmed/30576342
Capicua is a fast-acting transcriptional brake. Patel AL, Zhang L, Keenan SE, Rushlow CA, Fradin C, Shvartsman SY Current biology : CB 34166605 Curr Biol 2021 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/34166605
Optogenetic Rescue of a Patterning Mutant. Johnson HE, Djabrayan NJV, Shvartsman SY, Toettcher JE Current biology : CB 32707057 Curr Biol 2020 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/32707057
Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold. Carrasco-López C, Zhao EM, Gil AA, Alam N, Toettcher JE, Avalos JL Nature communications 32792484 Nat Commun 2020 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/32792484
Optogenetic control of protein binding using light-switchable nanobodies. Gil AA, Carrasco-López C, Zhu L, Zhao EM, Ravindran PT, Wilson MZ, Goglia AG, Avalos JL, Toettcher JE Nature communications 32792536 Nat Commun 2020 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/32792536
Deconstructing and repurposing the light-regulated interplay between Arabidopsis phytochromes and interacting factors. Golonka D, Fischbach P, Jena SG, Kleeberg JRW, Essen LO, Toettcher JE, Zurbriggen MD, Möglich A Communications biology 31815202 Commun Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31815202
Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems. Farahani PE, Reed EH, Underhill EJ, Aoki K, Toettcher JE Annual review of biomedical engineering 33722063 Annu Rev Biomed Eng 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/33722063
A bright future: optogenetics to dissect the spatiotemporal control of cell behavior. Goglia AG, Toettcher JE Current opinion in chemical biology 30529586 Curr Opin Chem Biol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30529586
P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer. Barrio-Real L, Lopez-Haber C, Casado-Medrano V, Goglia AG, Toettcher JE, Caloca MJ, Kazanietz MG Oncotarget 29983884 Oncotarget 2018 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/29983884
Light-based control of metabolic flux through assembly of synthetic organelles. Zhao EM, Suek N, Wilson MZ, Dine E, Pannucci NL, Gitai Z, Avalos JL, Toettcher JE Nature chemical biology 31086330 Nat Chem Biol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31086330
Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD Cell systems 29960885 Cell Syst 2018 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/29960885
Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo. Johnson HE, Toettcher JE Developmental cell 30753836 Dev Cell 2019 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/30753836
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Dine E, Reed EH, Toettcher JE Cell reports 34161759 Cell Rep 2021 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/34161759
Optogenetic Amplification Circuits for Light-Induced Metabolic Control. Zhao EM, Lalwani MA, Chen JM, Orillac P, Toettcher JE, Avalos JL ACS synthetic biology 33835777 ACS Synth Biol 2021 May 21 https://www.ncbi.nlm.nih.gov/pubmed/33835777
The Spatiotemporal Limits of Developmental Erk Signaling. Johnson HE, Goyal Y, Pannucci NL, Schüpbach T, Shvartsman SY, Toettcher JE Developmental cell 28118601 Dev Cell 2017 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/28118601
Optimizing photoswitchable MEK. Patel AL, Yeung E, McGuire SE, Wu AY, Toettcher JE, Burdine RD, Shvartsman SY Proceedings of the National Academy of Sciences of the United States of America 31796593 Proc Natl Acad Sci U S A 2019 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/31796593
Dynamics of Drosophila endoderm specification. Keenan SE, Avdeeva M, Yang L, Alber DS, Wieschaus EF, Shvartsman SY Proceedings of the National Academy of Sciences of the United States of America 35412853 Proc Natl Acad Sci U S A 2022 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/35412853
A self-exciting point process to study multicellular spatial signaling patterns. Verma A, Jena SG, Isakov DR, Aoki K, Toettcher JE, Engelhardt BE Proceedings of the National Academy of Sciences of the United States of America 34362843 Proc Natl Acad Sci U S A 2021 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/34362843
Substratum stiffness regulates Erk signaling dynamics through receptor-level control. Farahani PE, Lemke SB, Dine E, Uribe G, Toettcher JE, Nelson CM Cell reports 34965432 Cell Rep 2021 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/34965432
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA Science (New York, N.Y.) 30166458 Science 2018 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/30166458
Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Dine E, Gil AA, Uribe G, Brangwynne CP, Toettcher JE Cell systems 29859829 Cell Syst 2018 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/29859829
Illuminating developmental biology with cellular optogenetics. Johnson HE, Toettcher JE Current opinion in biotechnology 29505976 Curr Opin Biotechnol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29505976
Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. Zhao EM, Lalwani MA, Lovelett RJ, García-Echauri SA, Hoffman SM, Gonzalez CL, Toettcher JE, Kevrekidis IG, Avalos JL ACS synthetic biology 33232598 ACS Synth Biol 2020 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/33232598
Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. Lovelett RJ, Zhao EM, Lalwani MA, Toettcher JE, Kevrekidis IG, L Avalos J ACS synthetic biology 33492138 ACS Synth Biol 2021 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/33492138
A Universal Live Cell Barcoding-Platform for Multiplexed Human Single Cell Analysis. Hartmann FJ, Simonds EF, Bendall SC Scientific reports 30018331 Sci Rep 2018 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/30018331
A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging. Keren L, Bosse M, Marquez D, Angoshtari R, Jain S, Varma S, Yang SR, Kurian A, Van Valen D, West R, Bendall SC, Angelo M Cell 30193111 Cell 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/30193111
Single-cell metabolic profiling of human cytotoxic T cells. Hartmann FJ, Mrdjen D, McCaffrey E, Glass DR, Greenwald NF, Bharadwaj A, Khair Z, Verberk SGS, Baranski A, Baskar R, Graf W, Van Valen D, Van den Bossche J, Angelo M, Bendall SC Nature biotechnology 32868913 Nat Biotechnol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/32868913
Immune monitoring using mass cytometry and related high-dimensional imaging approaches. Hartmann FJ, Bendall SC Nature reviews. Rheumatology 31892734 Nat Rev Rheumatol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31892734
The basis of cellular and regional vulnerability in Alzheimer's disease. Mrdjen D, Fox EJ, Bukhari SA, Montine KS, Bendall SC, Montine TJ Acta neuropathologica 31392412 Acta Neuropathol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31392412
MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure. Keren L, Bosse M, Thompson S, Risom T, Vijayaragavan K, McCaffrey E, Marquez D, Angoshtari R, Greenwald NF, Fienberg H, Wang J, Kambham N, Kirkwood D, Nolan G, Montine TJ, Galli SJ, West R, Bendall SC, Angelo M Science advances 31633026 Sci Adv 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31633026
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Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors. Favaro P, Glass DR, Borges L, Baskar R, Reynolds W, Ho D, Bruce T, Tebaykin D, Scanlon VM, Shestopalov I, Bendall SC bioRxiv : the preprint server for biology 37693547 bioRxiv 2023 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/37693547
NK-like CD8(+) γδ T cells are expanded in persistent Mycobacterium tuberculosis infection. Roy Chowdhury R, Valainis JR, Dubey M, von Boehmer L, Sola E, Wilhelmy J, Guo J, Kask O, Ohanyan M, Sun M, Huang H, Huang X, Nguyen PK, Scriba TJ, Davis MM, Bendall SC, Chien YH Science immunology 37000856 Sci Immunol 2023 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/37000856
Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells. Good Z, Borges L, Vivanco Gonzalez N, Sahaf B, Samusik N, Tibshirani R, Nolan GP, Bendall SC Nature biotechnology 30742126 Nat Biotechnol 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30742126
High-Parameter Immune Profiling with CyTOF. Sahaf B, Rahman A, Maecker HT, Bendall SC Methods in molecular biology (Clifton, N.J.) 31502160 Methods Mol Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/31502160
Mass synaptometry: High-dimensional multi parametric assay for single synapses. Gajera CR, Fernandez R, Postupna N, Montine KS, Fox EJ, Tebaykin D, Angelo M, Bendall SC, Keene CD, Montine TJ Journal of neuroscience methods 30465796 J Neurosci Methods 2019 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/30465796
Mass-tag barcoding for multiplexed analysis of human synaptosomes and other anuclear events. Gajera CR, Fernandez R, Montine KS, Fox EJ, Mrdjen D, Postupna NO, Keene CD, Bendall SC, Montine TJ Cytometry. Part A : the journal of the International Society for Analytical Cytology 33818911 Cytometry A 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33818911
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Multiplexed single-cell morphometry for hematopathology diagnostics. Tsai AG, Glass DR, Juntilla M, Hartmann FJ, Oak JS, Fernandez-Pol S, Ohgami RS, Bendall SC Nature medicine 32161403 Nat Med 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32161403
Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells. Kimmey SC, Borges L, Baskar R, Bendall SC Nature communications 30862852 Nat Commun 2019 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/30862852
4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. Miao S, Zhu W, Castro NJ, Nowicki M, Zhou X, Cui H, Fisher JP, Zhang LG Scientific reports 27251982 Sci Rep 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27251982
Four-Dimensional Printing Hierarchy Scaffolds with Highly Biocompatible Smart Polymers for Tissue Engineering Applications. Miao S, Zhu W, Castro NJ, Leng J, Zhang LG Tissue engineering. Part C, Methods 28195832 Tissue Eng Part C Methods 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/28195832
Engineering a Novel 3D Printed Vascularized Tissue Model for Investigating Breast Cancer Metastasis to Bone. Cui H, Esworthy T, Zhou X, Hann SY, Glazer RI, Li R, Zhang LG Advanced healthcare materials 31846231 Adv Healthc Mater 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/31846231
Biologically Inspired Smart Release System Based on 3D Bioprinted Perfused Scaffold for Vascularized Tissue Regeneration. Cui H, Zhu W, Holmes B, Zhang LG Advanced science (Weinheim, Baden-Wurttemberg, Germany) 27818910 Adv Sci (Weinh) 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27818910
Design of a Novel 3D Printed Bioactive Nanocomposite Scaffold for Improved Osteochondral Regeneration. Castro NJ, Patel R, Zhang LG Cellular and molecular bioengineering 26366231 Cell Mol Bioeng 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26366231
3D Bioprinting for Organ Regeneration. Cui H, Nowicki M, Fisher JP, Zhang LG Advanced healthcare materials 27995751 Adv Healthc Mater 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27995751
A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair. Holmes B, Bulusu K, Plesniak M, Zhang LG Nanotechnology 26758780 Nanotechnology 2016 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/26758780
Enhanced bone tissue regeneration using a 3D printed microstructure incorporated with a hybrid nano hydrogel. Heo DN, Castro NJ, Lee SJ, Noh H, Zhu W, Zhang LG Nanoscale 28211933 Nanoscale 2017 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/28211933
Advanced 4D Bioprinting Technologies for Brain Tissue Modeling and Study. Esworthy TJ, Miao S, Lee SJ, Zhou X, Cui H, Zuo YY, Zhang LG International journal of smart and nano materials 32864037 Int J Smart Nano Mater 2019 https://www.ncbi.nlm.nih.gov/pubmed/32864037
In vitro and in vivo evaluation of 3D bioprinted small-diameter vasculature with smooth muscle and endothelium. Cui H, Zhu W, Huang Y, Liu C, Yu ZX, Nowicki M, Miao S, Cheng Y, Zhou X, Lee SJ, Zhou Y, Wang S, Mohiuddin M, Horvath K, Zhang LG Biofabrication 31470437 Biofabrication 2019 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/31470437
Integration of biological systems with electronic-mechanical assemblies. Yi N, Cui H, Zhang LG, Cheng H Acta biomaterialia 31004844 Acta Biomater 2019 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/31004844
Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design. Cui H, Zhu W, Nowicki M, Zhou X, Khademhosseini A, Zhang LG Advanced healthcare materials 27383032 Adv Healthc Mater 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27383032
A 3D printed nano bone matrix for characterization of breast cancer cell and osteoblast interactions. Zhu W, Castro NJ, Cui H, Zhou X, Boualam B, McGrane R, Glazer RI, Zhang LG Nanotechnology 27346678 Nanotechnology 2016 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/27346678
4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction. Cui H, Liu C, Esworthy T, Huang Y, Yu ZX, Zhou X, San H, Lee SJ, Hann SY, Boehm M, Mohiuddin M, Fisher JP, Zhang LG Science advances 32637623 Sci Adv 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32637623
Photolithographic-stereolithographic-tandem fabrication of 4D smart scaffolds for improved stem cell cardiomyogenic differentiation. Miao S, Cui H, Nowicki M, Lee SJ, Almeida J, Zhou X, Zhu W, Yao X, Masood F, Plesniak MW, Mohiuddin M, Zhang LG Biofabrication 29651999 Biofabrication 2018 May 2 https://www.ncbi.nlm.nih.gov/pubmed/29651999
Integrating three-dimensional printing and nanotechnology for musculoskeletal regeneration. Nowicki M, Castro NJ, Rao R, Plesniak M, Zhang LG Nanotechnology 28762957 Nanotechnology 2017 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/28762957
Recent advances in 3D printing: vascular network for tissue and organ regeneration. Hann SY, Cui H, Esworthy T, Miao S, Zhou X, Lee SJ, Fisher JP, Zhang LG Translational research : the journal of laboratory and clinical medicine 31004563 Transl Res 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31004563
3D Printed Stretchable Tactile Sensors. Guo SZ, Qiu K, Meng F, Park SH, McAlpine MC Advanced materials (Deerfield Beach, Fla.) 28474793 Adv Mater 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28474793
3D Printed Organ Models for Surgical Applications. Qiu K, Haghiashtiani G, McAlpine MC Annual review of analytical chemistry (Palo Alto, Calif.) 29589961 Annu Rev Anal Chem (Palo Alto Calif) 2018 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/29589961
3D Printed Neural Regeneration Devices. Joung D, Lavoie NS, Guo SZ, Park SH, Parr AM, McAlpine MC Advanced functional materials 32038121 Adv Funct Mater 2020 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/32038121
3D Printed Bionic Nanodevices. Kong YL, Gupta MK, Johnson BN, McAlpine MC Nano today 27617026 Nano Today 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27617026
3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments. Meng F, Meyer CM, Joung D, Vallera DA, McAlpine MC, Panoskaltsis-Mortari A Advanced materials (Deerfield Beach, Fla.) 30663123 Adv Mater 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30663123
3D Printed Skin-Interfaced UV-Visible Hybrid Photodetectors. Ouyang X, Su R, Ng DWH, Han G, Pearson DR, McAlpine MC Advanced science (Weinheim, Baden-Wurttemberg, Germany) 35818683 Adv Sci (Weinh) 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35818683
3D-printed flexible organic light-emitting diode displays. Su R, Park SH, Ouyang X, Ahn SI, McAlpine MC Science advances 34995118 Sci Adv 2022 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/34995118
3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors. Qiu K, Zhao Z, Haghiashtiani G, Guo SZ, He M, Su R, Zhu Z, Bhuiyan DB, Murugan P, Meng F, Park SH, Chu CC, Ogle BM, Saltzman DA, Konety BR, Sweet RM, McAlpine MC Advanced materials technologies 29608202 Adv Mater Technol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29608202
3D printed self-supporting elastomeric structures for multifunctional microfluidics. Su R, Wen J, Su Q, Wiederoder MS, Koester SJ, Uzarski JR, McAlpine MC Science advances 33036980 Sci Adv 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33036980
The Role of Nanoparticle Design in Determining Analytical Performance of Lateral Flow Immunoassays. Zhan L, Guo SZ, Song F, Gong Y, Xu F, Boulware DR, McAlpine MC, Chan WCW, Bischof JC Nano letters 29120648 Nano Lett 2017 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/29120648
3D Printed Functional and Biological Materials on Moving Freeform Surfaces. Zhu Z, Guo SZ, Hirdler T, Eide C, Fan X, Tolar J, McAlpine MC Advanced materials (Deerfield Beach, Fla.) 29691902 Adv Mater 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29691902
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3D printed patient-specific aortic root models with internal sensors for minimally invasive applications. Haghiashtiani G, Qiu K, Zhingre Sanchez JD, Fuenning ZJ, Nair P, Ahlberg SE, Iaizzo PA, McAlpine MC Science advances 32923641 Sci Adv 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32923641
3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds. Joung D, Truong V, Neitzke CC, Guo SZ, Walsh PJ, Monat JR, Meng F, Park SH, Dutton JR, Parr AM, McAlpine MC Advanced functional materials 32595422 Adv Funct Mater 2018 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/32595422
Conduction Cooling and Plasmonic Heating Dramatically Increase Droplet Vitrification Volumes for Cell Cryopreservation. Zhan L, Guo SZ, Kangas J, Shao Q, Shiao M, Khosla K, Low WC, McAlpine MC, Bischof J Advanced science (Weinheim, Baden-Wurttemberg, Germany) 34141523 Adv Sci (Weinh) 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34141523
3D Printed Polymer Photodetectors. Park SH, Su R, Jeong J, Guo SZ, Qiu K, Joung D, Meng F, McAlpine MC Advanced materials (Deerfield Beach, Fla.) 30151842 Adv Mater 2018 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/30151842
3D Printed Programmable Release Capsules. Gupta MK, Meng F, Johnson BN, Kong YL, Tian L, Yeh YW, Masters N, Singamaneni S, McAlpine MC Nano letters 26042472 Nano Lett 2015 Aug 12 https://www.ncbi.nlm.nih.gov/pubmed/26042472
3D Printed Electrically-Driven Soft Actuators. Haghiashtiani G, Habtour E, Park SH, Gardea F, McAlpine MC Extreme Mechanics Letters 32596434 Extreme Mech Lett 2018 May https://www.ncbi.nlm.nih.gov/pubmed/32596434
3D printed deformable sensors. Zhu Z, Park HS, McAlpine MC Science advances 32596461 Sci Adv 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32596461
In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid. Kupfer ME, Lin WH, Ravikumar V, Qiu K, Wang L, Gao L, Bhuiyan DB, Lenz M, Ai J, Mahutga RR, Townsend D, Zhang J, McAlpine MC, Tolkacheva EG, Ogle BM Circulation research 32228120 Circ Res 2020 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/32228120
Setting the dynein motor in motion: New insights from electron tomography. Grotjahn DA, Lander GC The Journal of biological chemistry 31285262 J Biol Chem 2019 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/31285262
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity. Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B Proceedings of the National Academy of Sciences of the United States of America 28438998 Proc Natl Acad Sci U S A 2017 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/28438998
The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading. Gardner BM, Castanzo DT, Chowdhury S, Stjepanovic G, Stefely MS, Hurley JH, Lander GC, Martin A Nature communications 29321502 Nat Commun 2018 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/29321502
Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC Science advances 32490208 Sci Adv 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32490208
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC Nature structural & molecular biology 29416113 Nat Struct Mol Biol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29416113
The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL The EMBO journal 28655754 EMBO J 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28655754
An allosteric network in spastin couples multiple activities required for microtubule severing. Sandate CR, Szyk A, Zehr EA, Lander GC, Roll-Mecak A Nature structural & molecular biology 31285604 Nat Struct Mol Biol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31285604
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY Nature communications 31431622 Nat Commun 2019 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/31431622
Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A Cell 25959773 Cell 2015 May 21 https://www.ncbi.nlm.nih.gov/pubmed/25959773
Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation. de la Peña AH, Goodall EA, Gates SN, Lander GC, Martin A Science (New York, N.Y.) 30309908 Science 2018 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/30309908
The rod-shaped ATG2A-WIPI4 complex tethers membranes in vitro. Otomo T, Chowdhury S, Lander GC Contact (Thousand Oaks (Ventura County, Calif.)) 30766969 Contact (Thousand Oaks) 2018 Jan-Dec https://www.ncbi.nlm.nih.gov/pubmed/30766969
Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome. Bashore C, Dambacher CM, Goodall EA, Matyskiela ME, Lander GC, Martin A Nature structural & molecular biology 26301997 Nat Struct Mol Biol 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26301997
Exploring applications of crowdsourcing to cryo-EM. Bruggemann J, Lander GC, Su AI Journal of structural biology 29486249 J Struct Biol 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29486249
Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis. Wu M, Lander GC Biophysical journal 32919493 Biophys J 2020 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/32919493
Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama F, Partch CL eLife 32101164 Elife 2020 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/32101164
Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC Science (New York, N.Y.) 29097521 Science 2017 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/29097521
Structure of the cold- and menthol-sensing ion channel TRPM8. Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY Science (New York, N.Y.) 29217583 Science 2018 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/29217583
Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV. Herzik MA Jr, Wu M, Lander GC Nature methods 28991891 Nat Methods 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28991891
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Hirschi M, Herzik MA Jr, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY Nature 29019979 Nature 2017 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/29019979
A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality. Herzik MA Jr, Fraser JS, Lander GC Structure (London, England : 1993) 30449687 Structure 2019 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/30449687
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex. Chowdhury S, Otomo C, Leitner A, Ohashi K, Aebersold R, Lander GC, Otomo T Proceedings of the National Academy of Sciences of the United States of America 30185561 Proc Natl Acad Sci U S A 2018 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/30185561
A guided approach for subtomogram averaging of challenging macromolecular assemblies. Basanta B, Chowdhury S, Lander GC, Grotjahn DA Journal of structural biology: X 33319208 J Struct Biol X 2020 https://www.ncbi.nlm.nih.gov/pubmed/33319208
AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex. Hirschi M, Lu WT, Santiago-Frangos A, Wilkinson R, Golden SM, Davidson AR, Lander GC, Wiedenheft B Nature communications 32483187 Nat Commun 2020 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/32483187
Site-specific labeling of proteins for electron microscopy. Dambacher CM, Lander GC Journal of structural biology 26409249 J Struct Biol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26409249
Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. Dambacher CM, Worden EJ, Herzik MA, Martin A, Lander GC eLife 26744777 Elife 2016 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/26744777
Isolation of yeast complex IV in native lipid nanodiscs. Smirnova IA, Sjöstrand D, Li F, Björck M, Schäfer J, Östbye H, Högbom M, von Ballmoos C, Lander GC, Ädelroth P, Brzezinski P Biochimica et biophysica acta 27620332 Biochim Biophys Acta 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27620332
The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits. Gardner BM, Chowdhury S, Lander GC, Martin A Journal of molecular biology 25659908 J Mol Biol 2015 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/25659908
Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B Cell 28340349 Cell 2017 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/28340349
Cryo-EM structure of a mitochondrial calcium uniporter. Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY Science (New York, N.Y.) 29954988 Science 2018 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/29954988
Structural organization of the dynein-dynactin complex bound to microtubules. Chowdhury S, Ketcham SA, Schroer TA, Lander GC Nature structural & molecular biology 25751425 Nat Struct Mol Biol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25751425
Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Puchades C, Ding B, Song A, Wiseman RL, Lander GC, Glynn SE Molecular cell 31327635 Mol Cell 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/31327635
High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM. Herzik MA Jr, Wu M, Lander GC Nature communications 30833564 Nat Commun 2019 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/30833564
Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry. Rollins MF, Chowdhury S, Carter J, Golden SM, Miettinen HM, Santiago-Frangos A, Faith D, Lawrence CM, Lander GC, Wiedenheft B Molecular cell 30872121 Mol Cell 2019 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/30872121
The molecular principles governing the activity and functional diversity of AAA+ proteins. Puchades C, Sandate CR, Lander GC Nature reviews. Molecular cell biology 31754261 Nat Rev Mol Cell Biol 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31754261
Conformational ensemble of the human TRPV3 ion channel. Zubcevic L, Herzik MA Jr, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY Nature communications 30429472 Nat Commun 2018 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/30429472
Contact Line Pinning Is Not Required for Nanobubble Stability on Copolymer Brushes. Bull DS, Nelson N, Konetski D, Bowman CN, Schwartz DK, Goodwin AP The journal of physical chemistry letters 30010342 J Phys Chem Lett 2018 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/30010342
Surface-Templated Nanobubbles Protect Proteins from Surface-Mediated Denaturation. Bull DS, Kienle DF, Chaparro Sosa AF, Nelson N, Roy S, Cha JN, Schwartz DK, Kaar JL, Goodwin AP The journal of physical chemistry letters 31067058 J Phys Chem Lett 2019 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/31067058
Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy. Harguindey A, Roy S, Harris AW, Fairbanks BD, Goodwin AP, Bowman CN, Cha JN Biomacromolecules 30884222 Biomacromolecules 2019 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/30884222
Depolymerizable Poly(O-vinyl carbamate-alt-sulfones) as Customizable Macromolecular Scaffolds for Mucosal Drug Delivery. Kumar K, Castaño EJ, Weidner AR, Yildirim A, Goodwin AP ACS macro letters 28480130 ACS Macro Lett 2016 May 17 https://www.ncbi.nlm.nih.gov/pubmed/28480130
DNA-Assembled Core-Satellite Upconverting-Metal-Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy. He L, Brasino M, Mao C, Cho S, Park W, Goodwin AP, Cha JN Small (Weinheim an der Bergstrasse, Germany) 28481463 Small 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28481463
Understanding Acoustic Cavitation Initiation by Porous Nanoparticles: Toward Nanoscale Agents for Ultrasound Imaging and Therapy. Yildirim A, Chattaraj R, Blum NT, Goodwin AP Chemistry of materials : a publication of the American Chemical Society 28484307 Chem Mater 2016 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/28484307
Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photoconjugation and Increased Retention in Tumors. Brasino M, Roy S, Erbse AH, He L, Mao C, Park W, Cha JN, Goodwin AP Journal of the American Chemical Society 30203972 J Am Chem Soc 2018 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/30203972
Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing. Chattaraj R, Mohan P, Besmer JD, Goodwin AP Advanced healthcare materials 26084414 Adv Healthc Mater 2015 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/26084414
Mutually-Reactive, Fluorogenic Hydrocyanine/Quinone Reporter Pairs for In-Solution Biosensing via Nanodroplet Association. Chattaraj R, Mohan P, Livingston CM, Besmer JD, Kumar K, Goodwin AP ACS applied materials & interfaces 26710239 ACS Appl Mater Interfaces 2016 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/26710239
Conversion of Ethanol to 2-Ethylhexenal at Ambient Conditions Using Tandem, Biphasic Catalysis. Hafenstine GR, Harris AW, Ma K, Cha JN, Goodwin AP ACS sustainable chemistry & engineering 33224638 ACS Sustain Chem Eng 2017 https://www.ncbi.nlm.nih.gov/pubmed/33224638
Light-Driven Catalytic Upgrading of Butanol in a Biohybrid Photoelectrochemical System. Harris AW, Yehezkeli O, Hafenstine GR, Goodwin AP, Cha JN ACS sustainable chemistry & engineering 33133786 ACS Sustain Chem Eng 2017 https://www.ncbi.nlm.nih.gov/pubmed/33133786
Solar Photocatalytic Phenol Polymerization and Hydrogen Generation for Flocculation of Wastewater Impurities. Hafenstine GR, Patalano RE, Harris AW, Jiang G, Ma K, Goodwin AP, Cha JN ACS applied polymer materials 37206614 ACS Appl Polym Mater 2019 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/37206614
Alternating Sulfone Copolymers Depolymerize in Response to Both Chemical and Mechanical Stimuli. Kumar K, Goodwin AP ACS macro letters 28480129 ACS Macro Lett 2015 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/28480129
Nanoparticles Formed by Acoustic Destruction of Microbubbles and Their Utilization for Imaging and Effects on Therapy by High Intensity Focused Ultrasound. Blum NT, Yildirim A, Chattaraj R, Goodwin AP Theranostics 28255360 Theranostics 2017 https://www.ncbi.nlm.nih.gov/pubmed/28255360
Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation. Yildirim A, Chattaraj R, Blum NT, Shi D, Kumar K, Goodwin AP Advanced healthcare materials 28699308 Adv Healthc Mater 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28699308
Phase Behavior of Mixed Lipid Monolayers on Perfluorocarbon Nanoemulsions and its Effect on Acoustic Contrast. Chattaraj R, Goldscheitter GM, Yildirim A, Goodwin AP RSC advances 28603605 RSC Adv 2016 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/28603605
Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation. Domaille DW, Hafenstine GR, Greer MA, Goodwin AP, Cha JN ACS sustainable chemistry & engineering 28480149 ACS Sustain Chem Eng 2016 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/28480149
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Polyacrylamide Hydrogels Produce Hydrogen Peroxide from Osmotic Swelling in Aqueous Media. Parameswar AV, Fitch KR, Bull DS, Duke VR, Goodwin AP Biomacromolecules 30052430 Biomacromolecules 2018 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/30052430
Multicatalytic, Light-Driven Upgrading of Butanol to 2-Ethylhexenal and Hydrogen under Mild Aqueous Conditions. Hafenstine GR, Ma K, Harris AW, Yehezkeli O, Park E, Domaille DW, Cha JN, Goodwin AP ACS catalysis 33133753 ACS Catal 2017 https://www.ncbi.nlm.nih.gov/pubmed/33133753
Phospholipid-Coated Hydrophobic Mesoporous Silica Nanoparticles Enhance Thrombectomy by High-Intensity Focused Ultrasound with Low Production of Embolism-Inducing Clot Debris. Blum NT, Gyorkos CM, Narowetz SJ, Mueller EN, Goodwin AP ACS applied materials & interfaces 31556582 ACS Appl Mater Interfaces 2019 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/31556582
Design and Application of Stimulus-Responsive Droplets and Bubbles Stabilized by Phospholipid Monolayers. Chattaraj R, Blum NT, Goodwin AP Current opinion in colloid & interface science 31086500 Curr Opin Colloid Interface Sci 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/31086500
Enzymes Photo-Cross-Linked to Live Cell Receptors Retain Activity and EGFR Inhibition after Both Internalization and Recycling. Roy S, Brasino M, Beirne JM, Harguindey A, Chapnick DA, Liu X, Cha JN, Goodwin AP Bioconjugate chemistry 31840981 Bioconjug Chem 2020 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/31840981
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Single dish gradient screening of small molecule localization. Beuzer P, Axelrod J, Trzoss L, Fenical W, Dasari R, Evidente A, Kornienko A, Cang H, La Clair JJ Organic & biomolecular chemistry 27530345 Org Biomol Chem 2016 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/27530345
Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. Gimple RC, Kidwell RL, Kim LJY, Sun T, Gromovsky AD, Wu Q, Wolf M, Lv D, Bhargava S, Jiang L, Prager BC, Wang X, Ye Q, Zhu Z, Zhang G, Dong Z, Zhao L, Lee D, Bi J, Sloan AE, Mischel PS, Brown JM, Cang H, Huan T, Mack SC, Xie Q, Rich JN Cancer discovery 31201181 Cancer Discov 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31201181
Ritterostatin G(N) 1(N) , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78. Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kumar Kanduluru A, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ Chembiochem : a European journal of chemical biology 28074539 Chembiochem 2017 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/28074539
Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. Fan JB, Miyauchi S, Xu HZ, Liu D, Kim LJY, Burkart C, Cheng H, Arimoto KI, Yan M, Zhou Y, Győrffy B, Knobeloch KP, Rich JN, Cang H, Fu XD, Zhang DE Cancer discovery 31974171 Cancer Discov 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31974171
Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy. Xu H, Tong Z, Ye Q, Sun T, Hong Z, Zhang L, Bortnick A, Cho S, Beuzer P, Axelrod J, Hu Q, Wang M, Evans SM, Murre C, Lu LF, Sun S, Corbett KD, Cang H Proceedings of the National Academy of Sciences of the United States of America 31444302 Proc Natl Acad Sci U S A 2019 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/31444302
Adiabatic far-field sub-diffraction imaging. Cang H, Salandrino A, Wang Y, Zhang X Nature communications 26258769 Nat Commun 2015 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/26258769
Droplet-based transcriptome profiling of individual synapses. Niu M, Cao W, Wang Y, Zhu Q, Luo J, Wang B, Zheng H, Weitz DA, Zong C Nature biotechnology 36646931 Nat Biotechnol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/36646931
Single-cell Damagenome Profiling by Linear Copying and Splitting based Whole Genome Amplification (LCS-WGA). Niu Y, Zhu Q, Zong C Bio-protocol 35434195 Bio Protoc 2022 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/35434195
Single-cell total-RNA profiling unveils regulatory hubs of transcription factors. Niu Y, Luo J, Zong C Nature communications 39009595 Nat Commun 2024 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/39009595
Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage. Zhu Q, Niu Y, Gundry M, Zong C Science advances 34215579 Sci Adv 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34215579
Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer. Yamauchi M, Gibbons DL, Zong C, Fradette JJ, Bota-Rabassedas N, Kurie JM Matrix biology : journal of the International Society for Matrix Biology 32442601 Matrix Biol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32442601
Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence. Liu S, Cao W, Niu Y, Luo J, Zhao Y, Hu Z, Zong C eLife 33983114 Elife 2021 May 13 https://www.ncbi.nlm.nih.gov/pubmed/33983114
Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1. Jen HI, Hill MC, Tao L, Sheng K, Cao W, Zhang H, Yu HV, Llamas J, Zong C, Martin JF, Segil N, Groves AK eLife 31033441 Elife 2019 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/31033441
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch. Oakes BL, Nadler DC, Flamholz A, Fellmann C, Staahl BT, Doudna JA, Savage DF Nature biotechnology 27136077 Nat Biotechnol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27136077
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR Nature biotechnology 31110355 Nat Biotechnol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31110355
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification. Oakes BL, Fellmann C, Rishi H, Taylor KL, Ren SM, Nadler DC, Yokoo R, Arkin AP, Doudna JA, Savage DF Cell 30633905 Cell 2019 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/30633905
Rapid and Programmable Protein Mutagenesis Using Plasmid Recombineering. Higgins SA, Ouonkap SVY, Savage DF ACS synthetic biology 28707884 ACS Synth Biol 2017 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/28707884
Rapid construction of metabolite biosensors using domain-insertion profiling. Nadler DC, Morgan SA, Flamholz A, Kortright KE, Savage DF Nature communications 27470466 Nat Commun 2016 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/27470466
Protein engineering of Cas9 for enhanced function. Oakes BL, Nadler DC, Savage DF Methods in enzymology 25398355 Methods Enzymol 2014 https://www.ncbi.nlm.nih.gov/pubmed/25398355
Biofuel metabolic engineering with biosensors. Morgan SA, Nadler DC, Yokoo R, Savage DF Current opinion in chemical biology 27768949 Curr Opin Chem Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27768949
Cas14: Big Advances from Small CRISPR Proteins. Savage DF Biochemistry 30740978 Biochemistry 2019 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/30740978
Imaging and three-dimensional reconstruction of chemical groups inside a protein complex using atomic force microscopy. Kim D, Sahin O Nature nanotechnology 25664622 Nat Nanotechnol 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25664622
Calibration of T-shaped atomic force microscope cantilevers using the thermal noise method. Kim Y, Mandriota N, Goodnight D, Sahin O The Review of scientific instruments 32872926 Rev Sci Instrum 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32872926
Cellular nanoscale stiffness patterns governed by intracellular forces. Mandriota N, Friedsam C, Jones-Molina JA, Tatem KV, Ingber DE, Sahin O Nature materials 31209386 Nat Mater 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31209386
Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes. Wei L, Hu F, Chen Z, Shen Y, Zhang L, Min W Accounts of chemical research 27486796 Acc Chem Res 2016 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/27486796
Spectral tracing of deuterium for imaging glucose metabolism. Zhang L, Shi L, Shen Y, Miao Y, Wei M, Qian N, Liu Y, Min W Nature biomedical engineering 31036888 Nat Biomed Eng 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31036888
A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering. Zeng C , Hu F , Long R , Min W The Analyst 30246812 Analyst 2018 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/30246812
Supermultiplexed optical imaging and barcoding with engineered polyynes. Hu F, Zeng C, Long R, Miao Y, Wei L, Xu Q, Min W Nature methods 29334378 Nat Methods 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29334378
Two-color vibrational imaging of glucose metabolism using stimulated Raman scattering. Long R, Zhang L, Shi L, Shen Y, Hu F, Zeng C, Min W Chemical communications (Cambridge, England) 29218356 Chem Commun (Camb) 2018 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/29218356
Applications of vibrational tags in biological imaging by Raman microscopy. Zhao Z, Shen Y, Hu F, Min W The Analyst 28875184 Analyst 2017 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/28875184
Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette. Chen Z, Paley DW, Wei L, Weisman AL, Friesner RA, Nuckolls C, Min W Journal of the American Chemical Society 24849912 J Am Chem Soc 2014 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/24849912
Operando and three-dimensional visualization of anion depletion and lithium growth by stimulated Raman scattering microscopy. Cheng Q, Wei L, Liu Z, Ni N, Sang Z, Zhu B, Xu W, Chen M, Miao Y, Chen LQ, Min W, Yang Y Nature communications 30061610 Nat Commun 2018 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/30061610
Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering. Hu F, Chen Z, Zhang L, Shen Y, Wei L, Min W Angewandte Chemie (International ed. in English) 26207979 Angew Chem Int Ed Engl 2015 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/26207979
Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy. Wei L, Yu Y, Shen Y, Wang MC, Min W Proceedings of the National Academy of Sciences of the United States of America 23798434 Proc Natl Acad Sci U S A 2013 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/23798434
Super-multiplex vibrational imaging. Wei L, Chen Z, Shi L, Long R, Anzalone AV, Zhang L, Hu F, Yuste R, Cornish VW, Min W Nature 28424513 Nature 2017 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/28424513
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering. Wei L, Hu F, Shen Y, Chen Z, Yu Y, Lin CC, Wang MC, Min W Nature methods 24584195 Nat Methods 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24584195
Live-cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling. Hu F, Wei L, Zheng C, Shen Y, Min W The Analyst 24555181 Analyst 2014 May 21 https://www.ncbi.nlm.nih.gov/pubmed/24555181
Imaging complex protein metabolism in live organisms by stimulated Raman scattering microscopy with isotope labeling. Wei L, Shen Y, Xu F, Hu F, Harrington JK, Targoff KL, Min W ACS chemical biology 25560305 ACS Chem Biol 2015 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/25560305
Optical imaging of metabolic dynamics in animals. Shi L, Zheng C, Shen Y, Chen Z, Silveira ES, Zhang L, Wei M, Liu C, de Sena-Tomas C, Targoff K, Min W Nature communications 30082908 Nat Commun 2018 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/30082908
Live-cell quantitative imaging of proteome degradation by stimulated Raman scattering. Shen Y, Xu F, Wei L, Hu F, Min W Angewandte Chemie (International ed. in English) 24737659 Angew Chem Int Ed Engl 2014 May 26 https://www.ncbi.nlm.nih.gov/pubmed/24737659
Bioorthogonal chemical imaging of metabolic activities in live mammalian hippocampal tissues with stimulated Raman scattering. Hu F, Lamprecht MR, Wei L, Morrison B, Min W Scientific reports 28000773 Sci Rep 2016 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/28000773
Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging. Hu F, Brucks SD, Lambert TH, Campos LM, Min W Chemical communications (Cambridge, England) 28474031 Chem Commun (Camb) 2017 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/28474031
Metabolic activity induces membrane phase separation in endoplasmic reticulum. Shen Y, Zhao Z, Zhang L, Shi L, Shahriar S, Chan RB, Di Paolo G, Min W Proceedings of the National Academy of Sciences of the United States of America 29196526 Proc Natl Acad Sci U S A 2017 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/29196526
Electronic Preresonance Stimulated Raman Scattering Microscopy. Wei L, Min W The journal of physical chemistry letters 30001137 J Phys Chem Lett 2018 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/30001137
Bioorthogonal chemical imaging of metabolic changes during epithelial-mesenchymal transition of cancer cells by stimulated Raman scattering microscopy. Zhang L, Min W Journal of biomedical optics 29043713 J Biomed Opt 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29043713
Surface charge controlled nucleoli selective staining with nanoscale carbon dots. Zhu Z, Li Q, Li P, Xun X, Zheng L, Ning D, Su M PloS one 31150413 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/31150413
Monte Carlo and analytic simulations in nanoparticle-enhanced radiation therapy. Paro AD, Hossain M, Webster TJ, Su M International journal of nanomedicine 27695329 Int J Nanomedicine 2016 https://www.ncbi.nlm.nih.gov/pubmed/27695329
Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles. Zhang P, Qiao Y, Wang C, Ma L, Su M Nanoscale 25032891 Nanoscale 2014 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/25032891
Reducing X-Ray Induced Oxidative Damages in Fibroblasts with Graphene Oxide. Qiao Y, Zhang P, Wang C, Ma L, Su M Nanomaterials (Basel, Switzerland) 25530873 Nanomaterials (Basel) 2014 https://www.ncbi.nlm.nih.gov/pubmed/25530873
Multiplexed detection of molecular biomarkers with phase-change nanoparticles. Su M Nanomedicine (London, England) 23394155 Nanomedicine (Lond) 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23394155
Cationic surface modification of gold nanoparticles for enhanced cellular uptake and X-ray radiation therapy. Wang C, Sun A, Qiao Y, Zhang P, Ma L, Su M Journal of materials chemistry. B 26512323 J Mater Chem B 2015 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/26512323
Three-dimensional microtissues as an in vitro model for personalized radiation therapy. Qiu Y, Ning D, Zhang P, Curly S, Qiao Y, Ma L, Su M The Analyst 28812074 Analyst 2017 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/28812074
Chip-scale alignment of long DNA nanofibers on a patterned self-assembled monolayer. Xia J, Su M Lab on a chip 28820213 Lab Chip 2017 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/28820213
Whole slide imaging of circulating tumor cells captured on a capillary microchannel device. Zheng Y, Li Q, Hu W, Liao J, Zheng G, Su M Lab on a chip 31621763 Lab Chip 2019 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/31621763
Nanoparticle location and material dependent dose enhancement in X-ray radiation therapy. Hossain M, Su M The journal of physical chemistry. C, Nanomaterials and interfaces 23393610 J Phys Chem C Nanomater Interfaces 2012 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/23393610
Polydopamine Nanoparticles for Combined Chemo- and Photothermal Cancer Therapy. Zhu Z, Su M Nanomaterials (Basel, Switzerland) 28661423 Nanomaterials (Basel) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28661423
A noncanonical polyamine from bacteria antagonizes animal mitochondrial function. Nauta KM, Gates DR, Weiland M, Mechan-Llontop ME, Wang X, Nguyen KP, Isaguirre C, Genjdar MR, Sheldon RD, Krawczyk CM, Burton NO bioRxiv : the preprint server for biology 38746390 bioRxiv 2025 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/38746390
An ultrathin membrane mediates tissue-specific morphogenesis and barrier function in a human kidney chip. Mou X, Shah J, Roye Y, Du C, Musah S Science advances 38838141 Sci Adv 2024 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/38838141
Unleashing the power of biomaterials to enhance organoid differentiation and function. Musah S, Arzaghi H Nature methods 39179910 Nat Methods 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39179910
Fenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease. Mou X, Leeman SM, Roye Y, Miller C, Musah S International journal of molecular sciences 39201792 Int J Mol Sci 2024 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/39201792
Kidney Disease Modeling with Organoids and Organs-on-Chips. Musah S, Bhattacharya R, Himmelfarb J Annual review of biomedical engineering 38424088 Annu Rev Biomed Eng 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38424088
Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated SMAD2 mutations. Bhattacharya R, Ward T, Kalejaiye TD, Mishra A, Leeman S, Arzaghi H, Seidman JG, Seidman CE, Musah S bioRxiv : the preprint server for biology 39211233 bioRxiv 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39211233
Chemical interplay between gut microbiota and epigenetics: Implications in circadian biology. Sharma SA, Oladejo SO, Kuang Z Cell chemical biology 38776923 Cell Chem Biol 2025 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/38776923
Editorial: Environmental rhythms at the host-microbe interface. Brooks JF, Heath-Heckman E, Kuang Z Frontiers in genetics 37811149 Front Genet 2023 https://www.ncbi.nlm.nih.gov/pubmed/37811149
HDAC3 integrates TGF-β and microbial cues to program tuft cell biogenesis and diurnal rhythms in mucosal immune surveillance. Zhang J, Wang G, Ma J, Duan Y, Sharma SA, Oladejo S, Ma X, Arellano G, Orchard RC, Reese TA, Kuang Z Science immunology 39331726 Sci Immunol 2024 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/39331726
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan. Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S bioRxiv : the preprint server for biology 38585858 bioRxiv 2024 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/38585858
Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death. Lam B, Kajderowicz KM, Keys HR, Roessler JM, Frenkel EM, Kirkland A, Bisht P, El-Brolosy MA, Jaenisch R, Bell GW, Weissman JS, Griffith EC, Hrvatin S bioRxiv : the preprint server for biology 39091747 bioRxiv 2024 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/39091747
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan. Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S Nature aging 40055478 Nat Aging 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/40055478
Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindström NO, McMahon AP, Li Z Cell stem cell 38692273 Cell Stem Cell 2024 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/38692273
Building a kidney tree: Functional collecting duct from human pluripotent stem cells. Li Z, Lindström NO Developmental cell 36220079 Dev Cell 2022 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/36220079
Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, Zhang CC, Schreiber ME, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Lindström NO, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, McMahon AP, Li Z bioRxiv : the preprint server for biology 37293038 bioRxiv 2023 May 25 https://www.ncbi.nlm.nih.gov/pubmed/37293038
3D kidney organoids for bench-to-bedside translation. Gupta N, Dilmen E, Morizane R Journal of molecular medicine (Berlin, Germany) 33034708 J Mol Med (Berl) 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33034708
Live functional assays reveal longitudinal maturation of transepithelial transport in kidney organoids. Rizki-Safitri A, Gupta N, Hiratsuka K, Kobayashi K, Zhang C, Ida K, Satlin LM, Morizane R Frontiers in cell and developmental biology 36046340 Front Cell Dev Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/36046340
Navigating the kidney organoid: insights into assessment and enhancement of nephron function. Tabibzadeh N, Satlin LM, Jain S, Morizane R American journal of physiology. Renal physiology 37767571 Am J Physiol Renal Physiol 2023 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/37767571
Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery. Hiratsuka K, Miyoshi T, Kroll KT, Gupta NR, Valerius MT, Ferrante T, Yamashita M, Lewis JA, Morizane R Science advances 36129975 Sci Adv 2022 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/36129975
Engineering multicellular living systems-a Keystone Symposia report. Cable J, Arlotta P, Parker KK, Hughes AJ, Goodwin K, Mummery CL, Kamm RD, Engle SJ, Tagle DA, Boj SF, Stanton AE, Morishita Y, Kemp ML, Norfleet DA, May EE, Lu A, Bashir R, Feinberg AW, Hull SM, Gonzalez AL, Blatchley MR, Montserrat Pulido N, Morizane R, McDevitt TC, Mishra D, Mulero-Russe A Annals of the New York Academy of Sciences 36177947 Ann N Y Acad Sci 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36177947
Cryopreservation of human kidney organoids. Mashouf P, Tabibzadeh N, Kuraoka S, Oishi H, Morizane R Cellular and molecular life sciences : CMLS 39023560 Cell Mol Life Sci 2024 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/39023560
Advancing preclinical drug evaluation through automated 3D imaging for high-throughput screening with kidney organoids. Oishi H, Tabibzadeh N, Morizane R Biofabrication 38547531 Biofabrication 2024 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/38547531
Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury. Ettou S, Jung YL, Miyoshi T, Jain D, Hiratsuka K, Schumacher V, Taglienti ME, Morizane R, Park PJ, Kreidberg JA Science advances 32754639 Sci Adv 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32754639
3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake. Aceves JO, Heja S, Kobayashi K, Robinson SS, Miyoshi T, Matsumoto T, Schäffers OJM, Morizane R, Lewis JA Scientific reports 36056134 Sci Rep 2022 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/36056134
A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. Yoon SH, Meyer MB, Arevalo C, Tekguc M, Zhang C, Wang JS, Castro Andrade CD, Strauss K, Sato T, Benkusky NA, Lee SM, Berdeaux R, Foretz M, Sundberg TB, Xavier RJ, Adelmann CH, Brooks DJ, Anselmo A, Sadreyev RI, Rosales IA, Fisher DE, Gupta N, Morizane R, Greka A, Pike JW, Mannstadt M, Wein MN The Journal of clinical investigation 36862513 J Clin Invest 2023 May 1 https://www.ncbi.nlm.nih.gov/pubmed/36862513
Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. Ruiz-Babot G, Eceiza A, Abollo-Jiménez F, Malyukov M, Carlone DL, Borges K, Da Costa AR, Qarin S, Matsumoto T, Morizane R, Skarnes WC, Ludwig B, Chapple PJ, Guasti L, Storr HL, Bornstein SR, Breault DT Cell reports methods 37924815 Cell Rep Methods 2023 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/37924815
Advancements in therapeutic development: kidney organoids and organs on a chip. Tabibzadeh N, Morizane R Kidney international 38296026 Kidney Int 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38296026
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R Science translational medicine 35235339 Sci Transl Med 2022 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/35235339
Strategies for Improving Vascularization in Kidney Organoids: A Review of Current Trends. Konoe R, Morizane R Biology 37106704 Biology (Basel) 2023 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/37106704
ATP/ADP biosensor organoids for drug nephrotoxicity assessment. Susa K, Kobayashi K, Galichon P, Matsumoto T, Tamura A, Hiratsuka K, Gupta NR, Yazdi IK, Bonventre JV, Morizane R Frontiers in cell and developmental biology 36936695 Front Cell Dev Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36936695
Kidney organoids: a pioneering model for kidney diseases. Tekguc M, Gaal RCV, Uzel SGM, Gupta N, Riella LV, Lewis JA, Morizane R Translational research : the journal of laboratory and clinical medicine 35750295 Transl Res 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/35750295
Kidney development to kidney organoids and back again. Gupta N, Morizane R Seminars in cell & developmental biology 34627669 Semin Cell Dev Biol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/34627669
The NIH Somatic Cell Genome Editing program. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB Jr, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium Nature 33828315 Nature 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33828315
Kidney organoids in translational medicine: Disease modeling and regenerative medicine. Miyoshi T, Hiratsuka K, Saiz EG, Morizane R Developmental dynamics : an official publication of the American Association of Anatomists 30843293 Dev Dyn 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/30843293
Bioengineered Kidney Models: Methods and Functional Assessments. Rizki-Safitri A, Traitteur T, Morizane R Function (Oxford, England) 35330622 Function (Oxf) 2021 https://www.ncbi.nlm.nih.gov/pubmed/35330622
Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca(2+) signaling. Carrisoza-Gaytan R, Kroll KT, Hiratsuka K, Gupta NR, Morizane R, Lewis JA, Satlin LM American journal of physiology. Cell physiology 36745528 Am J Physiol Cell Physiol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36745528
Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies. Kroll KT, Mata MM, Homan KA, Micallef V, Carpy A, Hiratsuka K, Morizane R, Moisan A, Gubler M, Walz AC, Marrer-Berger E, Lewis JA Proceedings of the National Academy of Sciences of the United States of America 37603766 Proc Natl Acad Sci U S A 2023 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/37603766
Brain Defense of Glycemia in Health and Diabetes. Mirzadeh Z, Faber C Diabetes.. 39401393 Diabetes 2024 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/39401393
Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes? Mirzadeh Z, Faber CL, Schwartz MW Annual review of pharmacology and toxicology 34990204 Annu Rev Pharmacol Toxicol 2022 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/34990204
Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism. Faber CL, Deem JD, Phan BA, Doan TP, Ogimoto K, Mirzadeh Z, Schwartz MW, Morton GJ eLife 33527893 Elife 2021 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/33527893
COVID-19 Gastrointestinal Symptoms and Attenuation of the Immune Response to SARS-CoV-2. Miller J, Yan KS Gastroenterology 33753106 Gastroenterology 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33753106
Presentation of the Julius M. Friedenwald Medal to Timothy C. Wang, MD, AGAF. Abrams J, Camilleri M, Merchant J, Rustgi AK, Yan K Gastroenterology 35443933 Gastroenterology 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35443933
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids. Flashner S, Martin C, Matsuura N, Shimonosono M, Tomita Y, Morimoto M, Okolo O, Yu VX, Parikh AS, Klein-Szanto AJP, Yan K, Gabre JT, Lu C, Momen-Heravi F, Rustgi AK, Nakagawa H Journal of visualized experiments : JoVE 36622034 J Vis Exp 2022 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/36622034
Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Capdevila C, Miller J, Cheng L, Kornberg A, George JJ, Lee H, Botella T, Moon CS, Murray JW, Lam S, Calderon RI, Malagola E, Whelan G, Lin CS, Han A, Wang TC, Sims PA, Yan KS Cell 38848677 Cell 2024 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/38848677
Cellular origins and lineage relationships of the intestinal epithelium. Capdevila C, Trifas M, Miller J, Anderson T, Sims PA, Yan KS American journal of physiology. Gastrointestinal and liver physiology 34431400 Am J Physiol Gastrointest Liver Physiol 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34431400
R-SPONDIN2(+) mesenchymal cells form the bud tip progenitor niche during human lung development. Hein RFC, Wu JH, Holloway EM, Frum T, Conchola AS, Tsai YH, Wu A, Fine AS, Miller AJ, Szenker-Ravi E, Yan KS, Kuo CJ, Glass I, Reversade B, Spence JR Developmental cell 35679862 Dev Cell 2022 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/35679862
Single-Cell Studies of Intestinal Stem Cell Heterogeneity During Homeostasis and Regeneration. Norkin M, Capdevila C, Calderon RI, Su T, Trifas M, Ordóñez-Morán P, Yan KS Methods in molecular biology (Clifton, N.J.) 32705640 Methods Mol Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32705640
Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration. Jiang Z, Waterbury QT, Malagola E, Fu N, Kim W, Ochiai Y, Wu F, Guha C, Shawber CJ, Yan KS, Wang TC Cellular and molecular gastroenterology and hepatology 37898454 Cell Mol Gastroenterol Hepatol 2024 https://www.ncbi.nlm.nih.gov/pubmed/37898454
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease. Kornberg A, Botella T, Moon CS, Rao S, Gelbs J, Cheng L, Miller J, Bacarella AM, García-Vilas JA, Vargas J, Yu X, Krupska I, Bush E, Garcia-Carrasquillo R, Lebwohl B, Krishnareddy S, Lewis S, Green PHR, Bhagat G, Yan KS, Han A Science immunology 37450575 Sci Immunol 2023 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/37450575
Single-Cell Transcriptional Profiling of the Intestinal Epithelium. Capdevila C, Calderon RI, Bush EC, Sheldon-Collins K, Sims PA, Yan KS Methods in molecular biology (Clifton, N.J.) 32705639 Methods Mol Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32705639
3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers. Flashner S, Yan KS, Nakagawa H Microorganisms 34835308 Microorganisms 2021 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/34835308
Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury. Malagola E, Vasciaveo A, Ochiai Y, Kim W, Zheng B, Zanella L, Wang ALE, Middelhoff M, Nienhüser H, Deng L, Wu F, Waterbury QT, Belin B, LaBella J, Zamechek LB, Wong MH, Li L, Guha C, Cheng CW, Yan KS, Califano A, Wang TC Cell 38848678 Cell 2024 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/38848678
Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration. Maan ZN, Rinkevich Y, Barrera J, Chen K, Henn D, Foster D, Bonham CA, Padmanabhan J, Sivaraj D, Duscher D, Hu M, Yan K, Januszyk M, Longaker MT, Weissman IL, Gurtner GC Journal of clinical medicine 34575372 J Clin Med 2021 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/34575372
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer. Masuda K, Kornberg A, Miller J, Lin S, Suek N, Botella T, Secener KA, Bacarella AM, Cheng L, Ingham M, Rosario V, Al-Mazrou AM, Lee-Kong SA, Kiran RP, Stoeckius M, Smibert P, Del Portillo A, Oberstein PE, Sims PA, Yan KS, Han A JCI insight 35192548 JCI Insight 2022 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/35192548
Xiphoid nucleus of the midline thalamus controls cold-induced food seeking. Lal NK, Le P, Aggarwal S, Zhang A, Wang K, Qi T, Pang Z, Yang D, Nudell V, Yeo GW, Banks AS, Ye L Nature 37587337 Nature 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37587337
In situ identification of cellular drug targets in mammalian tissue. Pang Z, Schafroth MA, Ogasawara D, Wang Y, Nudell V, Lal NK, Yang D, Wang K, Herbst DM, Ha J, Guijas C, Blankman JL, Cravatt BF, Ye L Cell 35483372 Cell 2022 May 12 https://www.ncbi.nlm.nih.gov/pubmed/35483372
The Afferent Function of Adipose Innervation. Wang Y, Ye L Diabetes.. 38377447 Diabetes 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/38377447
Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope. Lovelace JW, Ma J, Yadav S, Chhabria K, Shen H, Pang Z, Qi T, Sehgal R, Zhang Y, Bali T, Vaissiere T, Tan S, Liu Y, Rumbaugh G, Ye L, Kleinfeld D, Stringer C, Augustine V Nature 37914931 Nature 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37914931
HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodies. Nudell V, Wang Y, Pang Z, Lal NK, Huang M, Shaabani N, Kanim W, Teijaro J, Maximov A, Ye L Nature methods 35347322 Nat Methods 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35347322
Cortical Representations of Conspecific Sex Shape Social Behavior. Kingsbury L, Huang S, Raam T, Ye LS, Wei D, Hu RK, Ye L, Hong W Neuron 32663438 Neuron 2020 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/32663438
Xiphoid nucleus of the midline thalamus controls cold-induced food seeking. Lal NK, Le P, Aggarwal S, Zhang A, Wang K, Qi T, Pang Z, Yang D, Nudell V, Yeo GW, Banks AS, Ye L bioRxiv : the preprint server for biology 36993706 bioRxiv 2023 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/36993706
A protocol to visualize on-target specific drug binding in mammalian tissue with cellular resolution using tissue clearing and click chemistry. Pang Z, Ye L STAR protocols 36313539 STAR Protoc 2022 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/36313539
Illuminating spatial pharmacology with in situ drug imaging. Pang Z, Ye L Clinical and translational medicine 36030504 Clin Transl Med 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/36030504
Somatosensory innervation of adipose tissues. Wang Y, Ye L Physiology & behavior 36965573 Physiol Behav 2023 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/36965573
Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity. Yang D, Wang Y, Qi T, Zhang X, Shen L, Ma J, Pang Z, Lal NK, McClatchy DB, Seradj SH, Leung VH, Wang K, Xie Y, Polli FS, Maximov A, Gonzalez OC, de Lecea L, Cline HT, Augustine V, Yates JR 3rd, Ye L Neuron 38266644 Neuron 2024 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/38266644
Brainstem Dbh(+) neurons control allergen-induced airway hyperreactivity. Su Y, Xu J, Zhu Z, Chin J, Xu L, Yu H, Nudell V, Dash B, Moya EA, Ye L, Nimmerjahn A, Sun X Nature 38987587 Nature 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38987587
TESOS: an integrated approach for uniform mesoscale imaging. Wang Y, Ye L Cell research 38168641 Cell Res 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38168641
The role of somatosensory innervation of adipose tissues. Wang Y, Leung VH, Zhang Y, Nudell VS, Loud M, Servin-Vences MR, Yang D, Wang K, Moya-Garzon MD, Li VL, Long JZ, Patapoutian A, Ye L Nature 36045288 Nature 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36045288
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation. Wang Y, Zhang Y, Leung V, Seradj SH, Sonmez U, Servin-Vences R, Lipomi D, Ye L, Patapoutian A bioRxiv : the preprint server for biology 39605632 bioRxiv 2024 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/39605632
Acetylcholine-synthesizing macrophages in subcutaneous fat are regulated by β(2) -adrenergic signaling. Knights AJ, Liu S, Ma Y, Nudell VS, Perkey E, Sorensen MJ, Kennedy RT, Maillard I, Ye L, Jun H, Wu J The EMBO journal 34459015 EMBO J 2021 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/34459015
Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection. Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Iskhakova M, Fernando MB, Deans PJM, Powell SK, Javidfar B, Murphy A, Peter C, Møeller R, Garcia MF, Kimura M, Iwasawa K, Crary J, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ bioRxiv : the preprint server for biology 32995783 bioRxiv 2020 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/32995783
Narrative engineering of the liver. Lee IS, Takebe T Current opinion in genetics & development 35700688 Curr Opin Genet Dev 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35700688
Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids. Reza HA, Farooqui Z, Reza AA, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T Stem cell reports 37832542 Stem Cell Reports 2023 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/37832542
Intercellular mRNA transfer alters the human pluripotent stem cell state. Yoneyama Y, Zhang RR, Maezawa M, Masaki H, Kimura M, Cai Y, Adam M, Parameswaran S, Mizuno N, Bhadury J, Maezawa S, Ochiai H, Nakauchi H, Potter SS, Weirauch MT, Takebe T Proceedings of the National Academy of Sciences of the United States of America 39841146 Proc Natl Acad Sci U S A 2025 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/39841146
In toto biological framework: Modeling interconnectedness during human development. Yoneyama Y, Wu Y, Mori K, Takebe T Developmental cell 39765224 Dev Cell 2025 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/39765224
Organogenesis in vitro. Iwasawa K, Takebe T Current opinion in cell biology 34352726 Curr Opin Cell Biol 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34352726
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. Marsee A, Roos FJM, Verstegen MMA, HPB Organoid Consortium, Gehart H, de Koning E, Lemaigre F, Forbes SJ, Peng WC, Huch M, Takebe T, Vallier L, Clevers H, van der Laan LJW, Spee B Cell stem cell 33961769 Cell Stem Cell 2021 May 6 https://www.ncbi.nlm.nih.gov/pubmed/33961769
Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T Nature protocols 33432231 Nat Protoc 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33432231
Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids. Miao Y, Tan C, Pek NM, Yu Z, Iwasawa K, Kechele DO, Sundaram N, Pastrana-Gomez V, Kishimoto K, Yang MC, Jiang C, Tchieu J, Whitsett JA, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen YW, Guo M, Gu M bioRxiv : the preprint server for biology 38370768 bioRxiv 2024 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/38370768
Cellotype-phenotype associations using 'organoid villages'. Kimura M, Takebe T Trends in endocrinology and metabolism: TEM 38575442 Trends Endocrinol Metab 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38575442
Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids. Sheth M, Sharma M, Lehn M, Reza H, Takebe T, Takiar V, Wise-Draper T, Esfandiari L APL bioengineering 39092008 APL Bioeng 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/39092008
Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State. Yoneyama Y, Zhang RR, Kimura M, Cai Y, Adam M, Parameswaran S, Masaki H, Mizuno N, Bhadury J, Maezawa S, Ochiai H, Nakauchi H, Potter SS, Weirauch MT, Takebe T bioRxiv : the preprint server for biology 38979277 bioRxiv 2024 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/38979277
Self-Organization of Sinusoidal Vessels in Pluripotent Stem Cell-derived Human Liver Bud Organoids. Saiki N, Nio Y, Yoneyama Y, Kawamura S, Iwasawa K, Kawakami E, Araki K, Fukumura J, Sakairi T, Kono T, Ohmura R, Koido M, Funata M, Thompson WL, Cruz-Encarnacion P, Chen YW, Takebe T bioRxiv : the preprint server for biology 39005378 bioRxiv 2024 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/39005378
Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease. Jurickova I, Dreskin BW, Angerman E, Bonkowski E, Nguyen J, Villarreal R, Tominaga K, Iwasawa K, Braun T, Takebe T, Helmrath MA, Haberman Y, Wells JM, Denson LA Journal of Crohn's & colitis 39212594 J Crohns Colitis 2025 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/39212594
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ Stem cell reports 33636110 Stem Cell Reports 2021 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/33636110
Polygenic architecture informs potential vulnerability to drug-induced liver injury. Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal GP, Daly AK, Watkins PB, Anayama H, Dragan Y, Shinozawa T, Takebe T Nature medicine 32895570 Nat Med 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32895570
Human liver model systems in a dish. Thompson WL, Takebe T Development, growth & differentiation 33423319 Dev Growth Differ 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33423319
Fetal liver hematopoiesis: from development to delivery. Lewis K, Yoshimoto M, Takebe T Stem cell research & therapy 33597015 Stem Cell Res Ther 2021 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/33597015
Generation of multi-cellular human liver organoids from pluripotent stem cells. Thompson WL, Takebe T Methods in cell biology 32586449 Methods Cell Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32586449
Organoid transplant approaches for the liver. Reza HA, Okabe R, Takebe T Transplant international : official journal of the European Society for Organ Transplantation 34614263 Transpl Int 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34614263
Synthesis and application of POLYseq for profiling human liver organoids. Dunn AW, Cai Y, Iwasawa K, Kimura M, Takebe T STAR protocols 34934958 STAR Protoc 2021 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/34934958
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19. Kawakami E, Saiki N, Yoneyama Y, Moriya C, Maezawa M, Kawamura S, Kinebuchi A, Kono T, Funata M, Sakoda A, Kondo S, Ebihara T, Matsumoto H, Togami Y, Ogura H, Sugihara F, Okuzaki D, Kojima T, Deguchi S, Vallee S, McQuade S, Islam R, Natarajan M, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Wu Y, Mori K, Hishiki T, Takasaki T, Itoh Y, Takayama K, Nio Y, Takebe T Cell stem cell 37802037 Cell Stem Cell 2023 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/37802037
POLYseq: A poly(β-amino ester)-based vector for multifunctional cellular barcoding. Dunn A, Cai Y, Iwasawa K, Kimura M, Takebe T Stem cell reports 34450040 Stem Cell Reports 2021 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/34450040
En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH. Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson WL, Yoneyama Y, Chaturvedi P, Zorn AM, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers RP, Subramanian GM, Hwa V, Takebe T Cell 36240780 Cell 2022 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/36240780
Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems. Kishimoto K, Iwasawa K, Sorel A, Ferran-Heredia C, Han L, Morimoto M, Wells JM, Takebe T, Zorn AM Nature protocols 35978039 Nat Protoc 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/35978039
In vitro human cell-based models: What can they do and what are their limitations? Lutolf MP, Radisic M, Beekman J, Huh DD, Huch M, Turco MY, Tahmasebi Birgani ZN, Gao D, Yao R, Lin H, Takebe T Cell 39178827 Cell 2024 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/39178827
ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH. Liu YJ, Kimura M, Li X, Sulc J, Wang Q, Rodríguez-López S, Scantlebery AML, Strotjohann K, Gallart-Ayala H, Vijayakumar A, Myers RP, Ivanisevic J, Houtkooper RH, Subramanian GM, Takebe T, Auwerx J Journal of hepatology 39181211 J Hepatol 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39181211
Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells. Al Reza H, Santangelo C, Al Reza A, Iwasawa K, Sachiko S, Glaser K, Bondoc A, Merola J, Takebe T bioRxiv : the preprint server for biology 39257824 bioRxiv 2024 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/39257824
Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells. Rezvani M, Lewis K, Quach S, Iwasawa K, Weihs J, Reza H, Cai Y, Kimura M, Zhang R, Milton Y, Chaturvedi P, Thorner K, Nayak RC, Munera JO, Kramer P, Davis B, Balamurugan A, Ait Ahmed Y, Finke M, Behncke RY, Guillot A, Haegerling R, Polansky J, Bufler P, Cancelas J, Wells J, Yoshimoto M, Takebe T bioRxiv : the preprint server for biology 39416072 bioRxiv 2024 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/39416072
The promise of human organoids in the digestive system. Funata M, Nio Y, Erion DM, Thompson WL, Takebe T Cell death and differentiation 33204011 Cell Death Differ 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33204011
High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, Koike H, Maezawa M, Zhang RR, Dunn A, Ferguson A, Togo S, Lewis K, Thompson WL, Asai A, Takebe T Gastroenterology 33039464 Gastroenterology 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33039464
Organoid-guided precision hepatology for metabolic liver disease. Osonoi S, Takebe T Journal of hepatology 38237864 J Hepatol 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38237864
A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis. Kang SY, Kimura M, Shrestha S, Lewis P, Lee S, Cai Y, Joshi P, Acharya P, Liu J, Yang Y, Sanchez JG, Ayyagari S, Alsberg E, Wells JM, Takebe T, Lee MY Advanced healthcare materials 37616035 Adv Healthc Mater 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/37616035
Within-host evolution of a gut pathobiont facilitates liver translocation. Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW Nature 35831502 Nature 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35831502
Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition. Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E Science (New York, N.Y.) 32675374 Science 2020 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/32675374
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Chen H, Rosen CE, González-Hernández JA, Song D, Potempa J, Ring AM, Palm NW Cell 37321219 Cell 2023 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/37321219
Small Molecule Metabolites at the Host-Microbiota Interface. Bishai JD, Palm NW Journal of immunology (Baltimore, Md. : 1950) 34544815 J Immunol 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34544815
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