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NIH Director's New Innovator  (NIA)

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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Author Journal Name PubMedID Journal Abbreviation Publication Date PubMedLink
Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning. Romanowicz KJ, Resnick C, Hinton SR, Plesa C Science advances 40802757 Sci Adv 2025 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/40802757
Exploring Antibiotic Resistance in Diverse Homologs of the Dihydrofolate Reductase Protein Family through Broad Mutational Scanning. Romanowicz KJ, Resnick C, Hinton SR, Plesa C bioRxiv : the preprint server for biology 39896582 bioRxiv 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/39896582
Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 30290244 J Control Release 2018 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/30290244
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device. Shepherd SJ, Warzecha CC, Yadavali S, El-Mayta R, Alameh MG, Wang L, Weissman D, Wilson JM, Issadore D, Mitchell MJ Nano letters 34189917 Nano Lett 2021 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/34189917
An ionizable lipid toolbox for RNA delivery. Han X, Zhang H, Butowska K, Swingle KL, Alameh MG, Weissman D, Mitchell MJ Nature communications 34903741 Nat Commun 2021 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/34903741
Microfluidic formulation of nanoparticles for biomedical applications. Shepherd SJ, Issadore D, Mitchell MJ Biomaterials 33965797 Biomaterials 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33965797
Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing. El-Mayta R, Padilla MS, Billingsley MM, Han X, Mitchell MJ Journal of visualized experiments : JoVE 36744791 J Vis Exp 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36744791
Nanoparticle protein corona: from structure and function to therapeutic targeting. Bashiri G, Padilla MS, Swingle KL, Shepherd SJ, Mitchell MJ, Wang K Lab on a chip 36655824 Lab Chip 2023 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/36655824
Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery. Zhang H, Han X, Alameh MG, Shepherd SJ, Padilla MS, Xue L, Butowska K, Weissman D, Mitchell MJ Journal of biomedical materials research. Part A 35076171 J Biomed Mater Res A 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35076171
In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH Proceedings of the National Academy of Sciences of the United States of America 39078677 Proc Natl Acad Sci U S A 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39078677
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Han X, Xu J, Xu Y, Alameh MG, Xue L, Gong N, El-Mayta R, Palanki R, Warzecha CC, Zhao G, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ Nature communications 38409275 Nat Commun 2024 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/38409275
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y Science advances 38416830 Sci Adv 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38416830
Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation. Atsavapranee E, Haley RM, Billingsley MM, Chan A, Ruan B, Figueroa-Espada CG, Gong N, Mukalel AJ, Bryan PN, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 38729436 J Control Release 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38729436
Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy. Swingle KL, Hamilton AG, Mitchell MJ Placenta 39181830 Placenta 2025 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/39181830
Piperazine-Derived Bisphosphonate-Based Ionizable Lipid Nanoparticles Enhance mRNA Delivery to the Bone Microenvironment. Yoon IC, Xue L, Chen Q, Liu J, Xu J, Siddiqui Z, Kim D, Chen B, Shi Q, Laura Han E, Cherry Ruiz M, Vining KH, Mitchell MJ Angewandte Chemie (International ed. in English) 39379320 Angew Chem Int Ed Engl 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39379320
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Zhao G, Xue L, Geisler HC, Xu J, Li X, Mitchell MJ, Vaughan AE Proceedings of the National Academy of Sciences of the United States of America 38315853 Proc Natl Acad Sci U S A 2024 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/38315853
Emerging strategies for nanomedicine in autoimmunity. Thatte AS, Billingsley MM, Weissman D, Melamed JR, Mitchell MJ Advanced drug delivery reviews 38342243 Adv Drug Deliv Rev 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38342243
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells. Patel SK, Billingsley MM, Frazee C, Han X, Swingle KL, Qin J, Alameh MG, Wang K, Weissman D, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 35569584 J Control Release 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35569584
Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ Nano letters 39688915 Nano Lett 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39688915
Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries. Hanna AR, Shepherd SJ, Datto GA, Navarro IB, Ricciardi AS, Padilla MS, Srikumar N, Zhang S, Yamagata HM, Meng NY, Buser JR, Mitchell MJ, Issadore DA bioRxiv : the preprint server for biology 40501993 bioRxiv 2025 May 29 https://www.ncbi.nlm.nih.gov/pubmed/40501993
Rational Design of Nanomedicine for Placental Disorders: Birthing a New Era in Women's Reproductive Health. Geisler HC, Safford HC, Mitchell MJ Small (Weinheim an der Bergstrasse, Germany) 37191231 Small 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/37191231
Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease. Palanki R, Bose SK, Dave A, White BM, Berkowitz C, Luks V, Yaqoob F, Han E, Swingle KL, Menon P, Hodgson E, Biswas A, Billingsley MM, Li L, Yiping F, Carpenter M, Trokhan A, Yeo J, Johana N, Wan TY, Alameh MG, Bennett FC, Storm PB, Jain R, Chan J, Weissman D, Mitchell MJ, Peranteau WH ACS nano 37458484 ACS Nano 2023 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/37458484
Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta. Safford HC, Swingle KL, Geisler HC, Hamilton AG, Thatte AS, Ghalsasi AA, Billingsley MM, Alameh MG, Weissman D, Mitchell MJ Small (Weinheim an der Bergstrasse, Germany) 37537704 Small 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/37537704
Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Hamilton AG, Swingle KL, Joseph RA, Mai D, Gong N, Billingsley MM, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ Advanced healthcare materials 37602495 Adv Healthc Mater 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37602495
Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Han EL, Padilla MS, Palanki R, Kim D, Mrksich K, Li JJ, Tang S, Yoon IC, Mitchell MJ Nano letters 38259198 Nano Lett 2024 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/38259198
Enhancing in situ cancer vaccines using delivery technologies. Gong N, Alameh MG, El-Mayta R, Xue L, Weissman D, Mitchell MJ Nature reviews. Drug discovery 38951662 Nat Rev Drug Discov 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38951662
Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Chan A, Haley RM, Najar MA, Gonzalez-Martinez D, Bugaj LJ, Burslem GM, Mitchell MJ, Tsourkas A Nature communications 38987546 Nat Commun 2024 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/38987546
Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ Lab on a chip 39037068 Lab Chip 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39037068
Ionizable lipid nanoparticles for in utero mRNA delivery. Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH, Mitchell MJ Science advances 33523869 Sci Adv 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33523869
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. Zhang D, Atochina-Vasserman EN, Maurya DS, Huang N, Xiao Q, Ona N, Liu M, Shahnawaz H, Ni H, Kim K, Billingsley MM, Pochan DJ, Mitchell MJ, Weissman D, Percec V Journal of the American Chemical Society 34324336 J Am Chem Soc 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34324336
Engineering precision nanoparticles for drug delivery. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R Nature reviews. Drug discovery 33277608 Nat Rev Drug Discov 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33277608
Delivery technologies for cancer immunotherapy. Riley RS, June CH, Langer R, Mitchell MJ Nature reviews. Drug discovery 30622344 Nat Rev Drug Discov 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30622344
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. Swingle KL, Billingsley MM, Bose SK, White B, Palanki R, Dave A, Patel SK, Gong N, Hamilton AG, Alameh MG, Weissman D, Peranteau WH, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 34742747 J Control Release 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34742747
Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition. Haley RM, Chan A, Billingsley MM, Gong N, Padilla MS, Kim EH, Wang H, Yin D, Wangensteen KJ, Tsourkas A, Mitchell MJ ACS applied materials & interfaces 37115558 ACS Appl Mater Interfaces 2023 May 10 https://www.ncbi.nlm.nih.gov/pubmed/37115558
siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy. Figueroa-Espada CG, Guimarães PPG, Riley RS, Xue L, Wang K, Mitchell MJ Cellular and molecular bioengineering 37810998 Cell Mol Bioeng 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37810998
Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery. Patel SK, Billingsley MM, Mukalel AJ, Thatte AS, Hamilton AG, Gong N, El-Mayta R, Safford HC, Merolle M, Mitchell MJ Theranostics 38164140 Theranostics 2024 https://www.ncbi.nlm.nih.gov/pubmed/38164140
In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism. Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ Small (Weinheim an der Bergstrasse, Germany) 38072809 Small 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38072809
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines. Shepherd SJ, Han X, Mukalel AJ, El-Mayta R, Thatte AS, Wu J, Padilla MS, Alameh MG, Srikumar N, Lee D, Weissman D, Issadore D, Mitchell MJ Proceedings of the National Academy of Sciences of the United States of America 37556502 Proc Natl Acad Sci U S A 2023 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/37556502
Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Gong N, Han X, Xue L, Billingsley MM, Huang X, El-Mayta R, Qin J, Sheppard NC, June CH, Mitchell MJ Nature biomedical engineering 38378820 Nat Biomed Eng 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38378820
EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 38789090 J Control Release 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38789090
High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ ACS nano 38861479 ACS Nano 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38861479
Peptide-functionalized nanoparticles for brain-targeted therapeutics. Tang S, Han EL, Mitchell MJ Drug delivery and translational research 40164912 Drug Deliv Transl Res 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/40164912
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Han X, Xu Y, Ricciardi A, Xu J, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Weissman D, Mitchell MJ bioRxiv : the preprint server for biology 40060499 bioRxiv 2025 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/40060499
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Han X, Alameh MG, Butowska K, Knox JJ, Lundgreen K, Ghattas M, Gong N, Xue L, Xu Y, Lavertu M, Bates P, Xu J, Nie G, Zhong Y, Weissman D, Mitchell MJ Nature nanotechnology 37365276 Nat Nanotechnol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37365276
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Han X, Alameh MG, Gong N, Xue L, Ghattas M, Bojja G, Xu J, Zhao G, Warzecha CC, Padilla MS, El-Mayta R, Dwivedi G, Xu Y, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ Nature chemistry 38982196 Nat Chem 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38982196
Elucidating lipid nanoparticle properties and structure through biophysical analyses. Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Joseph RA, Yamagata HM, Ricciardi AS, Mrksich K, Issadore D, Gupta K, Mitchell MJ bioRxiv : the preprint server for biology 39763759 bioRxiv 2025 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/39763759
Oxidized mRNA Lipid Nanoparticles for In Situ Chimeric Antigen Receptor Monocyte Engineering. Mukalel AJ, Hamilton AG, Billingsley MM, Li J, Thatte AS, Han X, Safford HC, Padilla MS, Papp T, Parhiz H, Weissman D, Mitchell MJ Advanced functional materials 39628840 Adv Funct Mater 2024 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/39628840
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ Nature nanotechnology 39354147 Nat Nanotechnol 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39354147
Biomaterials for vaccine-based cancer immunotherapy. Zhang R, Billingsley MM, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 30312721 J Control Release 2018 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/30312721
Nanomaterial Interactions with Human Neutrophils. Bisso PW, Gaglione S, Guimarães PPG, Mitchell MJ, Langer R ACS biomaterials science & engineering 31497639 ACS Biomater Sci Eng 2018 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/31497639
Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy. Mukalel AJ, Riley RS, Zhang R, Mitchell MJ Cancer letters 31100411 Cancer Lett 2019 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/31100411
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. Guimaraes PPG, Zhang R, Spektor R, Tan M, Chung A, Billingsley MM, El-Mayta R, Riley RS, Wang L, Wilson JM, Mitchell MJ Journal of controlled release : official journal of the Controlled Release Society 31678653 J Control Release 2019 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/31678653
Chiral Supraparticles for Controllable Nanomedicine. Yeom J, Guimaraes PPG, Ahn HM, Jung BK, Hu Q, McHugh K, Mitchell MJ, Yun CO, Langer R, Jaklenec A Advanced materials (Deerfield Beach, Fla.) 31686433 Adv Mater 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31686433
Peptide functionalized liposomes for receptor targeted cancer therapy. Aronson MR, Medina SH, Mitchell MJ APL bioengineering 33532673 APL Bioeng 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33532673
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver. Zhang R , El-Mayta R , Murdoch TJ , Warzecha CC , Billingsley MM , Shepherd SJ , Gong N , Wang L , Wilson JM , Lee D , Mitchell MJ Biomaterials science 33404020 Biomater Sci 2021 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/33404020
mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies. Thatte AS, Hamilton AG, Nachod BE, Mukalel AJ, Billingsley MM, Palanki R, Swingle KL, Mitchell MJ Nano letters 37906000 Nano Lett 2023 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/37906000
Cytosolic Delivery of Small Protein Scaffolds Enables Efficient Inhibition of Ras and Myc. Chan A, Wang HH, Haley RM, Song C, Gonzalez-Martinez D, Bugaj L, Mitchell MJ, Tsourkas A Molecular pharmaceutics 35225618 Mol Pharm 2022 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/35225618
Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Huang M, Yang F, Zhang D, Lin M, Duan H, El-Mayta R, Zhang L, Qin L, Shewale SV, Pei L, Mitchell MJ, Rader DJ, Fan Y, Gong Y Nature cardiovascular research 35571674 Nat Cardiovasc Res 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35571674
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy. Swingle KL, Safford HC, Geisler HC, Hamilton AG, Thatte AS, Billingsley MM, Joseph RA, Mrksich K, Padilla MS, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ Journal of the American Chemical Society 36789893 J Am Chem Soc 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36789893
A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma. Palanki R, Swingle KL, Mitchell MJ Clinical cancer research : an official journal of the American Association for Cancer Research 36190329 Clin Cancer Res 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36190329
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE Science translational medicine 38295183 Sci Transl Med 2024 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/38295183
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ Advanced materials (Deerfield Beach, Fla.) 38419362 Adv Mater 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38419362
Circular RNA lipid nanoparticle vaccine against SARS-CoV-2. Swingle KL, Hamilton AG, Han X, Liao KC, Safford HC, Thatte AS, Geisler HC, Xu J, Saw TY, Wan Y, Mitchell MJ Proceedings of the National Academy of Sciences of the United States of America 40953267 Proc Natl Acad Sci U S A 2025 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/40953267
Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets. Haley RM, Padilla MS, El-Mayta RD, Joseph RA, Weber JA, Figueroa-Espada CG, Mukalel AJ, Ricciardi AS, Palanki R, Geisler HC, Jester MT, Davidson BL, Mitchell MJ ACS nano 40183470 ACS Nano 2025 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/40183470
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Gong N, Zhong W, Alameh MG, Han X, Xue L, El-Mayta R, Zhao G, Vaughan AE, Qin Z, Xu F, Hamilton AG, Kim D, Xu J, Kim J, Teng X, Li J, Liang XJ, Weissman D, Guo W, Mitchell MJ Nature materials 39223270 Nat Mater 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39223270
Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen. Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ Journal of the American Chemical Society 39742515 J Am Chem Soc 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39742515
Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta. Safford HC, Shuler CF, Geisler HC, Thatte AS, Swingle KL, Han EL, Murray AM, Hamilton AG, Yamagata HM, Mitchell MJ Nano letters 40084657 Nano Lett 2025 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/40084657
Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome. Mrksich K, Padilla MS, Mitchell MJ Advanced drug delivery reviews 39293650 Adv Drug Deliv Rev 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39293650
Nanoparticle-Based Tolerogenic Vaccines: Next-Generation Strategies for Autoimmune and Allergic Disease Therapies. Nachod BE, Thatte AS, Palanki R, Mitchell MJ Angewandte Chemie (International ed. in English) 41451511 Angew Chem Int Ed Engl 2026 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/41451511
Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy. Shi Q, Gong N, Wang J, Palanki R, Zheng Q, Alameh MG, Dwivedi G, Davis B, Melamed J, Luo Z, Xu J, Figueroa-Espada CG, Xue L, Zeng Y, Han X, Kim D, Chen Q, Yamagata H, Geisler HC, El-Mayta R, Yoon IC, Weissman D, Mitchell MJ Nature nanotechnology 41851499 Nat Nanotechnol 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41851499
Nanotechnology-based strategies against SARS-CoV-2 variants. Huang X, Kon E, Han X, Zhang X, Kong N, Mitchell MJ, Peer D, Tao W Nature nanotechnology 35982317 Nat Nanotechnol 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35982317
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering. Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ Nano letters 31951421 Nano Lett 2020 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/31951421
Cyclodextrins in drug delivery: applications in gene and combination therapy. Haley RM, Gottardi R, Langer R, Mitchell MJ Drug delivery and translational research 32077052 Drug Deliv Transl Res 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32077052
Nanomaterials for T-cell cancer immunotherapy. Gong N, Sheppard NC, Billingsley MM, June CH, Mitchell MJ Nature nanotechnology 33437036 Nat Nanotechnol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33437036
Delivery technologies for in utero gene therapy. Palanki R, Peranteau WH, Mitchell MJ Advanced drug delivery reviews 33181188 Adv Drug Deliv Rev 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33181188
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ Nature communications 38424061 Nat Commun 2024 Feb 29 https://www.ncbi.nlm.nih.gov/pubmed/38424061
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. Mrksich K, Padilla MS, Joseph RA, Han EL, Kim D, Palanki R, Xu J, Mitchell MJ Journal of biomedical materials research. Part A 38487970 J Biomed Mater Res A 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38487970
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ Nature 39663452 Nature 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39663452
Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers. Sanati M, Figueroa-Espada CG, Han EL, Mitchell MJ, Yavari SA ACS nano 39666006 ACS Nano 2024 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/39666006
Lipid nanoparticle-mediated RNA delivery for immune cell modulation. Kim EH, Teerdhala SV, Padilla MS, Joseph RA, Li JJ, Haley RM, Mitchell MJ European journal of immunology 39279550 Eur J Immunol 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39279550
Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ Nature communications 39856035 Nat Commun 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/39856035
In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Guimarães PPG, Figueroa-Espada CG, Riley RS, Gong N, Xue L, Sewastianik T, Dennis PS, Loebel C, Chung A, Shepherd SJ, Haley RM, Hamilton AG, El-Mayta R, Wang K, Langer R, Anderson DG, Carrasco RD, Mitchell MJ Proceedings of the National Academy of Sciences of the United States of America 37310997 Proc Natl Acad Sci U S A 2023 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/37310997
Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain. Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva RY, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA ACS nano 37432926 ACS Nano 2023 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/37432926
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity. Zhong W, Lu Y, Han X, Yang J, Qin Z, Zhang W, Yu Z, Wu B, Liu S, Xu W, Zheng C, Schuchter LM, Karakousis GC, Mitchell TC, Amaravadi R, Flowers AJ, Gimotty PA, Xiao M, Mills G, Herlyn M, Dong H, Mitchell MJ, Kim J, Xu X, Guo W Cell reports 37805922 Cell Rep 2023 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/37805922
Lymphatic vessels in health and disease. Kesler CT, Liao S, Munn LL, Padera TP Wiley interdisciplinary reviews. Systems biology and medicine 23209022 Wiley Interdiscip Rev Syst Biol Med 2013 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/23209022
In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ Scientific reports 27377852 Sci Rep 2016 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/27377852
Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP Science translational medicine 29343625 Sci Transl Med 2018 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/29343625
Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography. Blatter C, Meijer EFJ, Padera TP, Vakoc BJ Journal of biophotonics 28700145 J Biophotonics 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/28700145
Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer. Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D Proceedings of the National Academy of Sciences of the United States of America 28900008 Proc Natl Acad Sci U S A 2017 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/28900008
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D The Journal of clinical investigation 28691930 J Clin Invest 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28691930
The Lymphatic System in Disease Processes and Cancer Progression. Padera TP, Meijer EF, Munn LL Annual review of biomedical engineering 26863922 Annu Rev Biomed Eng 2016 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/26863922
Mechanobiological oscillators control lymph flow. Kunert C, Baish JW, Liao S, Padera TP, Munn LL Proceedings of the National Academy of Sciences of the United States of America 26283382 Proc Natl Acad Sci U S A 2015 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/26283382
The lymph node microenvironment and its role in the progression of metastatic cancer. Pereira ER, Jones D, Jung K, Padera TP Seminars in cell & developmental biology 25620792 Semin Cell Dev Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25620792
Method for the quantitative measurement of collecting lymphatic vessel contraction in mice. Liao S, Jones D, Cheng G, Padera TP Journal of biological methods 25512945 J Biol Methods 2014 https://www.ncbi.nlm.nih.gov/pubmed/25512945
Solid stress impairs lymphocyte infiltration into lymph-node metastases. Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP Nature biomedical engineering 34282290 Nat Biomed Eng 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34282290
Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK Intravital 24353926 Intravital 2012 https://www.ncbi.nlm.nih.gov/pubmed/24353926
Local failure in parameningeal rhabdomyosarcoma correlates with poor response to induction chemotherapy. Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI International journal of radiation oncology, biology, physics 25864172 Int J Radiat Oncol Biol Phys 2015 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/25864172
Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25977256 FASEB J 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/25977256
Fate Mapping of Cancer Cells in Metastatic Lymph Nodes Using Photoconvertible Proteins. Pereira ER, Kedrin D, Padera TP Methods in molecular biology (Clifton, N.J.) 33704727 Methods Mol Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33704727
A retrospective analysis of commonly prescribed medications and the risk of developing breast cancer related lymphedema. Meijer EF, Bouta EM, Mendonca C, Skolny MN, Salama LW, Taghian AG, Padera TP Clinical research and trials 32864167 Clin Res Trials 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/32864167
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP Science (New York, N.Y.) 29567713 Science 2018 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/29567713
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK Nature biomedical engineering 30948807 Nat Biomed Eng 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30948807
Murine chronic lymph node window for longitudinal intravital lymph node imaging. Meijer EFJ, Jeong HS, Pereira ER, Ruggieri TA, Blatter C, Vakoc BJ, Padera TP Nature protocols 28683064 Nat Protoc 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28683064
Lymph node effective vascular permeability and chemotherapy uptake. Meijer EFJ, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP Microcirculation (New York, N.Y. : 1994) 28510992 Microcirculation 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28510992
Growth and Immune Evasion of Lymph Node Metastasis. Jones D, Pereira ER, Padera TP Frontiers in oncology 29527513 Front Oncol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29527513
Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells. Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP Angiogenesis 24201897 Angiogenesis 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24201897
Measuring Vascular Permeability In Vivo. Meijer EF, Baish JW, Padera TP, Fukumura D Methods in molecular biology (Clifton, N.J.) 27581015 Methods Mol Biol 2016 https://www.ncbi.nlm.nih.gov/pubmed/27581015
Reply to Davis: Nitric oxide regulates lymphatic contractions. Kunert C, Baish JW, Liao S, Padera TP, Munn LL Proceedings of the National Academy of Sciences of the United States of America 26719425 Proc Natl Acad Sci U S A 2016 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/26719425
Lymphatic function measurements influenced by contrast agent volume and body position. Bouta EM, Blatter C, Ruggieri TA, Meijer EF, Munn LL, Vakoc BJ, Padera TP JCI insight 29367467 JCI Insight 2018 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/29367467
Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation. Kuo AH, Ancukiewicz M, Kozak KR, Yock TI, Padera TP Radiation oncology (London, England) 25573181 Radiat Oncol 2015 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/25573181
Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP Journal of the National Cancer Institute 26063793 J Natl Cancer Inst 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26063793
Significance of lymph node metastasis in cancer dissemination of head and neck cancer. Cho JK, Hyun SH, Choi N, Kim MJ, Padera TP, Choi JY, Jeong HS Translational oncology 25926078 Transl Oncol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25926078
Editorial: rapid growth in the field of lymphatic biology. Padera TP Seminars in cell & developmental biology 25868083 Semin Cell Dev Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25868083
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK Cancer cell 25026209 Cancer Cell 2014 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/25026209
Novel molecular pathways in Gorham disease: implications for treatment. Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH Pediatric blood & cancer 24214028 Pediatr Blood Cancer 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24214028
Solid stress and elastic energy as measures of tumour mechanopathology. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK Nature biomedical engineering 28966873 Nat Biomed Eng 2016 https://www.ncbi.nlm.nih.gov/pubmed/28966873
Imaging the lymphatic system. Munn LL, Padera TP Microvascular research 24956510 Microvasc Res 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/24956510
Lymphatic function and immune regulation in health and disease. Liao S, Padera TP Lymphatic research and biology 24024577 Lymphat Res Biol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/24024577
Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK Journal of the National Cancer Institute 23899555 J Natl Cancer Inst 2013 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/23899555
Synchronization and Random Triggering of Lymphatic Vessel Contractions. Baish JW, Kunert C, Padera TP, Munn LL PLoS computational biology 27935958 PLoS Comput Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27935958
Inducible Nitric Oxide Synthase and CD11b(+)Gr1(+) Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP Lymphatic research and biology 30358484 Lymphat Res Biol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30358484
Low Efficiency Upconversion Nanoparticles for High-Resolution Coalignment of Near-Infrared and Visible Light Paths on a Light Microscope. Sundaramoorthy S, Garcia Badaracco A, Hirsch SM, Park JH, Davies T, Dumont J, Shirasu-Hiza M, Kummel AC, Canman JC ACS applied materials & interfaces 28221018 ACS Appl Mater Interfaces 2017 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/28221018
Microtubule Dynamics Scale with Cell Size to Set Spindle Length and Assembly Timing. Lacroix B, Letort G, Pitayu L, Sallé J, Stefanutti M, Maton G, Ladouceur AM, Canman JC, Maddox PS, Maddox AS, Minc N, Nédélec F, Dumont J Developmental cell 29787710 Dev Cell 2018 May 21 https://www.ncbi.nlm.nih.gov/pubmed/29787710
period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Allen VW, O'Connor RM, Ulgherait M, Zhou CG, Stone EF, Hill VM, Murphy KR, Canman JC, Ja WW, Shirasu-Hiza MM Current biology : CB 26748856 Curr Biol 2016 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/26748856
Kinetochore components are required for central spindle assembly. Maton G, Edwards F, Lacroix B, Stefanutti M, Laband K, Lieury T, Kim T, Espeut J, Canman JC, Dumont J Nature cell biology 26123112 Nat Cell Biol 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/26123112
High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis. Davies T, Jordan SN, Chand V, Sees JA, Laband K, Carvalho AX, Shirasu-Hiza M, Kovar DR, Dumont J, Canman JC Developmental cell 25073157 Dev Cell 2014 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/25073157
Kinetochore components are required for central spindle assembly. Maton G, Edwards F, Lacroix B, Stefanutti M, Laband K, Lieury T, Kim T, Espeut J, Canman JC, Dumont J Nature cell biology 25866924 Nat Cell Biol 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25866924
Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division. Jordan SN, Davies T, Zhuravlev Y, Dumont J, Shirasu-Hiza M, Canman JC The Journal of cell biology 26728855 J Cell Biol 2016 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/26728855
A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells. O'Connor RM, Stone EF, Wayne CR, Marcinkevicius EV, Ulgherait M, Delventhal R, Pantalia MM, Hill VM, Zhou CG, McAllister S, Chen A, Ziegenfuss JS, Grueber WB, Canman JC, Shirasu-Hiza MM The Journal of cell biology 28223318 J Cell Biol 2017 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/28223318
period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection. Allen VW, O'Connor RM, Ulgherait M, Zhou CG, Stone EF, Hill VM, Murphy KR, Canman JC, Ja WW, Shirasu-Hiza MM Current biology : CB 27218838 Curr Biol 2016 May 23 https://www.ncbi.nlm.nih.gov/pubmed/27218838
Stuck in the middle: Rac, adhesion, and cytokinesis. Davies T, Canman JC The Journal of cell biology 22945931 J Cell Biol 2012 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/22945931
Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans. Davies T, Sundaramoorthy S, Jordan SN, Shirasu-Hiza M, Dumont J, Canman JC Methods in cell biology 28065312 Methods Cell Biol 2017 https://www.ncbi.nlm.nih.gov/pubmed/28065312
Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Jordan SN, Canman JC Cytoskeleton (Hoboken, N.J.) 23047851 Cytoskeleton (Hoboken) 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/23047851
CYK-4 regulates Rac, but not Rho, during cytokinesis. Zhuravlev Y, Hirsch SM, Jordan SN, Dumont J, Shirasu-Hiza M, Canman JC Molecular biology of the cell 28298491 Mol Biol Cell 2017 May 1 https://www.ncbi.nlm.nih.gov/pubmed/28298491
Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per. Ulgherait M, Chen A, Oliva MK, Kim HX, Canman JC, Ja WW, Shirasu-Hiza M Cell metabolism 27916531 Cell Metab 2016 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/27916531
Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7 prevents chromosome segregation and cytokinesis defects in oocytes. Gigant E, Stefanutti M, Laband K, Gluszek-Kustusz A, Edwards F, Lacroix B, Maton G, Canman JC, Welburn JPI, Dumont J Development (Cambridge, England) 28289130 Development 2017 May 1 https://www.ncbi.nlm.nih.gov/pubmed/28289130
Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. Davies T, Kim HX, Romano Spica N, Lesea-Pringle BJ, Dumont J, Shirasu-Hiza M, Canman JC eLife 30028292 Elife 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/30028292
FLIRT: fast local infrared thermogenetics for subcellular control of protein function. Hirsch SM, Sundaramoorthy S, Davies T, Zhuravlev Y, Waters JC, Shirasu-Hiza M, Dumont J, Canman JC Nature methods 30377360 Nat Methods 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30377360
Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging. DelBove CE, Strothman CE, Lazarenko RM, Huang H, Sanders CR, Zhang Q Neurobiology of disease 30885793 Neurobiol Dis 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30885793
Ammonium chloride alters neuronal excitability and synaptic vesicle release. Lazarenko RM, DelBove CE, Strothman CE, Zhang Q Scientific reports 28698583 Sci Rep 2017 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/28698583
A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Gu H, Lazarenko RM, Koktysh D, Iacovitti L, Zhang Q Stem cells translational medicine 26025981 Stem Cells Transl Med 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26025981
Fluorescent Measurement of Synaptic Activity Using FM Dyes in Dissociated Hippocampal Cultured Neurons. Lazarenko RM, DelBove CE, Zhang Q Bio-protocol 29552593 Bio Protoc 2018 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/29552593
Effect of Competitive Surface Functionalization on Dual-Modality Fluorescence and Magnetic Resonance Imaging of Single-Walled Carbon Nanotubes. Hong T, Lazarenko RM, Colvin DC, Flores RL, Zhang Q, Xu YQ The journal of physical chemistry. C, Nanomaterials and interfaces 26644813 J Phys Chem C Nanomater Interfaces 2012 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/26644813
NKG2C, HLA-E and their association with psoriasis. Patel F, Marusina AI, Duong C, Adamopoulos IE, Maverakis E Experimental dermatology 24279916 Exp Dermatol 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24279916
Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. Park DD, Xu G, Wong M, Phoomak C, Liu M, Haigh NE, Wongkham S, Yang P, Maverakis E, Lebrilla CB Chemical science 30123482 Chem Sci 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/30123482
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review. Sukhov A, Adamopoulos IE, Maverakis E Clinical reviews in allergy & immunology 26780035 Clin Rev Allergy Immunol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/26780035
Classic Ulcerative Pyoderma Gangrenosum Is a T Cell-Mediated Disease Targeting Follicular Adnexal Structures: A Hypothesis Based on Molecular and Clinicopathologic Studies. Wang EA, Steel A, Luxardi G, Mitra A, Patel F, Cheng MY, Wilken R, Kao J, de Ga K, Sultani H, Merleev AA, Marusina AI, Brassard A, Fung MA, Konia T, Shimoda M, Maverakis E Frontiers in immunology 29379508 Front Immunol 2017 https://www.ncbi.nlm.nih.gov/pubmed/29379508
A site-specific map of the human plasma glycome and its age and gender-associated alterations. Merleev AA, Park D, Xie Y, Kailemia MJ, Xu G, Ruhaak LR, Kim K, Hong Q, Li Q, Patel F, Wan YY, Marusina AI, Adamopoulos IE, Lal NN, Mitra A, Le ST, Shimoda M, Luxardi G, Lebrilla CB, Maverakis E Scientific reports 33060657 Sci Rep 2020 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/33060657
Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion. Park D, Arabyan N, Williams CC, Song T, Mitra A, Weimer BC, Maverakis E, Lebrilla CB Molecular & cellular proteomics : MCP 27754876 Mol Cell Proteomics 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27754876
Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma. Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri S, Fiorentino D, Raychaudhuri SP, Maverakis E The Journal of investigative dermatology 26134944 J Invest Dermatol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26134944
Surface Glycans Regulate Salmonella Infection-Dependent Directional Switch in Macrophage Galvanotaxis Independent of NanH. Sun YH, Luxardi G, Xu G, Zhu K, Reid B, Guo BP, Lebrilla CB, Maverakis E, Zhao M Infection and immunity 34662214 Infect Immun 2022 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/34662214
Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab. He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, Konia T, Grando SA, Zone JJ, Maverakis E JAMA dermatology 25901938 JAMA Dermatol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25901938
Clonal Vγ6(+)Vδ4(+) T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection. Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, Cai SS, Limjunyawong N, Dong X, Yeaman MR, Simon SI, Shen W, Durum SK, O'Brien RL, Maverakis E, Miller LS Proceedings of the National Academy of Sciences of the United States of America 31088972 Proc Natl Acad Sci U S A 2019 May 28 https://www.ncbi.nlm.nih.gov/pubmed/31088972
Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A. Merleev AA, Marusina AI, Ma C, Elder JT, Tsoi LC, Raychaudhuri SP, Weidinger S, Wang EA, Adamopoulos IE, Luxardi G, Gudjonsson JE, Shimoda M, Maverakis E JCI insight 29997305 JCI Insight 2018 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/29997305
Peristomal pyoderma gangrenosum: An exceedingly rare and overdiagnosed entity? Le ST, Wang JZ, Alexanian C, Ellis S, Martinez-Alvarado YC, Johng S, Sood A, Maverakis E Journal of the American Academy of Dermatology 30772334 J Am Acad Dermatol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30772334
Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages. Sun Y, Reid B, Ferreira F, Luxardi G, Ma L, Lokken KL, Zhu K, Xu G, Sun Y, Ryzhuk V, Guo BP, Lebrilla CB, Maverakis E, Mogilner A, Zhao M PLoS biology 30964858 PLoS Biol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30964858
Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission. Safra N, Hitchens PL, Maverakis E, Mitra A, Korff C, Johnson E, Kol A, Bannasch MJ, Pedersen NC, Bannasch DL Veterinary immunology and immunopathology 27590423 Vet Immunol Immunopathol 2016 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/27590423
ITK inhibition for the targeted treatment of CTCL. Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, Marusina AI, Merleev AA, Wang EA, Sukhov A, Sultani H, Liu R, Bhardwaj G, Guo W, Kung HJ, Lam KS, Maverakis E Journal of dermatological science 28434812 J Dermatol Sci 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28434812
HDL Glycoprotein Composition and Site-Specific Glycosylation Differentiates Between Clinical Groups and Affects IL-6 Secretion in Lipopolysaccharide-Stimulated Monocytes. Krishnan S, Shimoda M, Sacchi R, Kailemia MJ, Luxardi G, Kaysen GA, Parikh AN, Ngassam VN, Johansen K, Chertow GM, Grimes B, Smilowitz JT, Maverakis E, Lebrilla CB, Zivkovic AM Scientific reports 28287093 Sci Rep 2017 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/28287093
CD4(+) virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity. Marusina AI, Ono Y, Merleev AA, Shimoda M, Ogawa H, Wang EA, Kondo K, Olney L, Luxardi G, Miyamura Y, Yilma TD, Villalobos IB, Bergstrom JW, Kronenberg DG, Soulika AM, Adamopoulos IE, Maverakis E Journal of autoimmunity 27894837 J Autoimmun 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27894837
T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1. Zhang W, Ono Y, Miyamura Y, Bowlus CL, Gershwin ME, Maverakis E Journal of autoimmunity 21636249 J Autoimmun 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21636249
Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential. Kharkar PM, Scott RA, Olney LP, LeValley PJ, Maverakis E, Kiick KL, Kloxin AM Advanced healthcare materials 29024487 Adv Healthc Mater 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29024487
Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical review. Maverakis E, Kim K, Shimoda M, Gershwin ME, Patel F, Wilken R, Raychaudhuri S, Ruhaak LR, Lebrilla CB Journal of autoimmunity 25578468 J Autoimmun 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25578468
Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes. Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, Watkins SM, Patel F, Billi AC, Wiedemann J, Izumiya Y, Kumar A, Uppala R, Kahlenberg JM, Liu FT, Adamopoulos IE, Wang EA, Ma C, Cheng MY, Xiong H, Kirane A, Luxardi G, Andersen B, Tsoi LC, Lebrilla CB, Gudjonsson JE, Maverakis E JCI insight 35900871 JCI Insight 2022 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/35900871
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Spo0A~P imposes a temporal gate for the bimodal expression of competence in Bacillus subtilis. Mirouze N, Desai Y, Raj A, Dubnau D PLoS genetics 22412392 PLoS Genet 2012 https://www.ncbi.nlm.nih.gov/pubmed/22412392
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Cabili MN, Dunagin MC, McClanahan PD, Biaesch A, Padovan-Merhar O, Regev A, Rinn JL, Raj A Genome biology 25630241 Genome Biol 2015 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/25630241
Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O'Shea JJ, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J Immunity 28930659 Immunity 2017 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/28930659
Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels. Dar RD, Shaffer SM, Singh A, Razooky BS, Simpson ML, Raj A, Weinberger LS PloS one 27467384 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27467384
What's Luck Got to Do with It: Single Cells, Multiple Fates, and Biological Nondeterminism. Symmons O, Raj A Molecular cell 27259209 Mol Cell 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27259209
A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition. Hsiung CC, Bartman CR, Huang P, Ginart P, Stonestrom AJ, Keller CA, Face C, Jahn KS, Evans P, Sankaranarayanan L, Giardine B, Hardison RC, Raj A, Blobel GA Genes & development 27340175 Genes Dev 2016 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/27340175
Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S Proceedings of the National Academy of Sciences of the United States of America 25197089 Proc Natl Acad Sci U S A 2014 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/25197089
The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development. Walton T, Preston E, Nair G, Zacharias AL, Raj A, Murray JI PLoS genetics 25738873 PLoS Genet 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25738873
Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms. Padovan-Merhar O, Nair GP, Biaesch AG, Mayer A, Scarfone S, Foley SW, Wu AR, Churchman LS, Singh A, Raj A Molecular cell 25866248 Mol Cell 2015 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/25866248
Targeting tumor vasculature: expanding the potential of DNA cancer vaccines. Ugel S, Facciponte JG, De Sanctis F, Facciabene A Cancer immunology, immunotherapy : CII 26267042 Cancer Immunol Immunother 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26267042
Rare Cell Detection by Single-Cell RNA Sequencing as Guided by Single-Molecule RNA FISH. Torre E, Dueck H, Shaffer S, Gospocic J, Gupte R, Bonasio R, Kim J, Murray J, Raj A Cell systems 29454938 Cell Syst 2018 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/29454938
Visualizing SNVs to quantify allele-specific expression in single cells. Levesque MJ, Ginart P, Wei Y, Raj A Nature methods 23913259 Nat Methods 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23913259
Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency. Abranches E, Guedes AM, Moravec M, Maamar H, Svoboda P, Raj A, Henrique D Development (Cambridge, England) 25005472 Development 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/25005472
Amendments: Author Correction: ClampFISH detects individual nucleic acid molecules using click chemistry-based amplification. Rouhanifard SH, Mellis IA, Dunagin M, Bayatpour S, Jiang CL, Dardani I, Symmons O, Emert B, Torre E, Cote A, Sullivan A, Stamatoyannopoulos JA, Raj A Nature biotechnology 30605160 Nat Biotechnol 2019 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/30605160
Turbo FISH: a method for rapid single molecule RNA FISH. Shaffer SM, Wu MT, Levesque MJ, Raj A PloS one 24066168 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24066168
Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation. Levesque MJ, Raj A Nature methods 23416756 Nat Methods 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23416756
Quantitative assessment of ratiometric bimolecular beacons as a tool for imaging single engineered RNA transcripts and measuring gene expression in living cells. Zhang X, Song Y, Shah AY, Lekova V, Raj A, Huang L, Behlke MA, Tsourkas A Nucleic acids research 23814183 Nucleic Acids Res 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23814183
Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting. Symmons O, Chang M, Mellis IA, Kalish JM, Park J, Suszták K, Bartolomei MS, Raj A PLoS genetics 30625149 PLoS Genet 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30625149
Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation. Nair G, Abranches E, Guedes AM, Henrique D, Raj A Scientific reports 26292941 Sci Rep 2015 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/26292941
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH Proceedings of the National Academy of Sciences of the United States of America 29078295 Proc Natl Acad Sci U S A 2017 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/29078295
Multiplexed detection of viral infections using rapid in situ RNA analysis on a chip. Shaffer SM, Joshi RP, Chambers BS, Sterken D, Biaesch AG, Gabrieli DJ, Li Y, Feemster KA, Hensley SE, Issadore D, Raj A Lab on a chip 26113495 Lab Chip 2015 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/26113495
Dynamic enhancer-gene body contacts during transcription elongation. Lee K, Hsiung CC, Huang P, Raj A, Blobel GA Genes & development 26443845 Genes Dev 2015 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/26443845
Using variability in gene expression as a tool for studying gene regulation. Padovan-Merhar O, Raj A Wiley interdisciplinary reviews. Systems biology and medicine 23996796 Wiley Interdiscip Rev Syst Biol Med 2013 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/23996796
Visualizing adenosine-to-inosine RNA editing in single mammalian cells. Mellis IA, Gupte R, Raj A, Rouhanifard SH Nature methods 28604724 Nat Methods 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28604724
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance. Shaffer SM, Dunagin MC, Torborg SR, Torre EA, Emert B, Krepler C, Beqiri M, Sproesser K, Brafford PA, Xiao M, Eggan E, Anastopoulos IN, Vargas-Garcia CA, Singh A, Nathanson KL, Herlyn M, Raj A Nature 28607484 Nature 2017 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/28607484
The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries. Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins JE, Blobel GA Molecular cell 28388437 Mol Cell 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28388437
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J Nature 27525555 Nature 2016 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/27525555
Nanoscale imaging of RNA with expansion microscopy. Chen F, Wassie AT, Cote AJ, Sinha A, Alon S, Asano S, Daugharthy ER, Chang JB, Marblestone A, Church GM, Raj A, Boyden ES Nature methods 27376770 Nat Methods 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27376770
Visualization of lncRNA by single-molecule fluorescence in situ hybridization. Dunagin M, Cabili MN, Rinn J, Raj A Methods in molecular biology (Clifton, N.J.) 25555572 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25555572
Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I. Xu J, Mercado-López X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, López CB mBio 26443454 mBio 2015 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/26443454
Half dozen of one, six billion of the other: What can small- and large-scale molecular systems biology learn from one another? Mellis IA, Raj A Genome research 26430156 Genome Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26430156
linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Maamar H, Cabili MN, Rinn J, Raj A Genes & development 23723417 Genes Dev 2013 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/23723417
Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant. Ginart P, Kalish JM, Jiang CL, Yu AC, Bartolomei MS, Raj A Genes & development 26944681 Genes Dev 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26944681
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a. Weis B, Schmidt J, Maamar H, Raj A, Lin H, Tóth C, Riedmann K, Raddatz G, Seitz HK, Ho AD, Lyko F, Linhart HG Oncogene 24837369 Oncogene 2015 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/24837369
Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature. Facciponte JG, Ugel S, De Sanctis F, Li C, Wang L, Nair G, Sehgal S, Raj A, Matthaiou E, Coukos G, Facciabene A The Journal of clinical investigation 24642465 J Clin Invest 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24642465
LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T Molecular cell 24857549 Mol Cell 2014 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/24857549
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL Nature structural & molecular biology 24463464 Nat Struct Mol Biol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24463464
Tailor made protein synthesis for HSCs. Barna M, Ruggero D Cell stem cell 24702992 Cell Stem Cell 2014 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/24702992
Cis-regulatory RNA elements that regulate specialized ribosome activity. Xue S, Barna M RNA biology 26327194 RNA Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26327194
The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Simsek D, Tiu GC, Flynn RA, Byeon GW, Leppek K, Xu AF, Chang HY, Barna M Cell 28575669 Cell 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28575669
RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation. Xue S, Tian S, Fujii K, Kladwang W, Das R, Barna M Nature 25409156 Nature 2015 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/25409156
Insights into kidney stem cell development and regeneration using zebrafish. Drummond BE, Wingert RA World journal of stem cells 26981168 World J Stem Cells 2016 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/26981168
Renal progenitors: Roles in kidney disease and regeneration. Chambers BE, Wingert RA World journal of stem cells 27928463 World J Stem Cells 2016 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/27928463
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. Gerlach GF, Wingert RA Developmental biology 25446529 Dev Biol 2014 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/25446529
Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and retinoic acid in zebrafish. Cheng CN, Wingert RA Developmental biology 25542995 Dev Biol 2015 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/25542995
Temporal and spatial expression of tight junction genes during zebrafish pronephros development. McKee R, Gerlach GF, Jou J, Cheng CN, Wingert RA Gene expression patterns : GEP 25460834 Gene Expr Patterns 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25460834
Flat mount preparation for observation and analysis of zebrafish embryo specimens stained by whole mount in situ hybridization. Cheng CN, Li Y, Marra AN, Verdun V, Wingert RA Journal of visualized experiments : JoVE 25078510 J Vis Exp 2014 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/25078510
Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration. McCampbell KK, Springer KN, Wingert RA Stem cells international 26089919 Stem Cells Int 2015 https://www.ncbi.nlm.nih.gov/pubmed/26089919
Zebrafish Renal Pathology: Emerging Models of Acute Kidney Injury. McKee RA, Wingert RA Current pathobiology reports 25973344 Curr Pathobiol Rep 2015 https://www.ncbi.nlm.nih.gov/pubmed/25973344
Roles of Iroquois Transcription Factors in Kidney Development. Marra AN, Wingert RA Cell & developmental biology 24855634 Cell Dev Biol 2014 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/24855634
Renal stem cells: fact or science fiction? McCampbell KK, Wingert RA The Biochemical journal 22574774 Biochem J 2012 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/22574774
Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation. McKee RA, Wingert RA Materials (Basel, Switzerland) 27375844 Materials (Basel) 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27375844
Renal stem cell reprogramming: Prospects in regenerative medicine. Morales EE, Wingert RA World journal of stem cells 25258667 World J Stem Cells 2014 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/25258667
Kidney organogenesis in the zebrafish: insights into vertebrate nephrogenesis and regeneration. Gerlach GF, Wingert RA Wiley interdisciplinary reviews. Developmental biology 24014448 Wiley Interdiscip Rev Dev Biol 2013 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/24014448
Congenital and Acute Kidney Disease: Translational Research Insights from Zebrafish Chemical Genetics. Poureetezadi SJ, Wingert RA General medicine (Los Angeles, Calif.) 24653992 Gen Med (Los Angel) 2013 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/24653992
Analysis of nephron composition and function in the adult zebrafish kidney. McCampbell KK, Springer KN, Wingert RA Journal of visualized experiments : JoVE 25145398 J Vis Exp 2014 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/25145398
Update on Janus kinase antagonists in inflammatory bowel disease. Boland BS, Sandborn WJ, Chang JT Gastroenterology clinics of North America 25110261 Gastroenterol Clin North Am 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25110261
Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι. Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley K, Akimoto K, Ohno S, Yeo GW, Chang JT Journal of immunology (Baltimore, Md. : 1950) 25617472 J Immunol 2015 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/25617472
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe SE, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang JT Journal of immunology (Baltimore, Md. : 1950) 25667416 J Immunol 2015 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/25667416
Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, Chang JT Oncotarget 26930717 Oncotarget 2016 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/26930717
USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis. Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT Molecular cancer research : MCR 29724812 Mol Cancer Res 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29724812
Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang JT, Gonzalez DJ, Nizet V Nature communications 26458291 Nat Commun 2015 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/26458291
Asymmetric Cell Division in T Lymphocyte Fate Diversification. Arsenio J, Metz PJ, Chang JT Trends in immunology 26474675 Trends Immunol 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26474675
Molecular regulation of effector and memory T cell differentiation. Chang JT, Wherry EJ, Goldrath AW Nature immunology 25396352 Nat Immunol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25396352
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Metz PJ, Lopez J, Kim SH, Akimoto K, Ohno S, Chang JT Scientific reports 26765121 Sci Rep 2016 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/26765121
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT Journal of immunology (Baltimore, Md. : 1950) 28515282 J Immunol 2017 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/28515282
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT The Journal of clinical investigation 28846070 J Clin Invest 2017 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/28846070
Early transcriptional and epigenetic regulation of CD8(+) T cell differentiation revealed by single-cell RNA sequencing. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW Nature immunology 28218746 Nat Immunol 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28218746
Ubiquitylation of CD98 limits cell proliferation and clonal expansion. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH Journal of cell science 26493331 J Cell Sci 2015 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/26493331
Reply to: "CD8(+) T cell diversification by asymmetric cell division". Arsenio J, Kakaradov B, Metz PJ, Yeo GW, Chang JT Nature immunology 26287585 Nat Immunol 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26287585
Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT Inflammatory bowel diseases 25545378 Inflamm Bowel Dis 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25545378
Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT Alimentary pharmacology & therapeutics 25041724 Aliment Pharmacol Ther 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25041724
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Arsenio J, Kakaradov B, Metz PJ, Kim SH, Yeo GW, Chang JT Nature immunology 24584088 Nat Immunol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24584088
Polarity and lymphocyte fate determination. Chang JT Current opinion in cell biology 22658837 Curr Opin Cell Biol 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22658837
Cutting edge: Asymmetric memory T cell division in response to rechallenge. Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL Journal of immunology (Baltimore, Md. : 1950) 22467651 J Immunol 2012 May 1 https://www.ncbi.nlm.nih.gov/pubmed/22467651
The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. Ngoi SM, Lopez JM, Chang JT Journal of immunology (Baltimore, Md. : 1950) 27029586 J Immunol 2016 May 15 https://www.ncbi.nlm.nih.gov/pubmed/27029586
Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT Journal of immunology (Baltimore, Md. : 1950) 29703862 J Immunol 2018 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/29703862
A gp130-Src-YAP module links inflammation to epithelial regeneration. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M Nature 25731159 Nature 2015 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/25731159
Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. Jung HR, Song KH, Chang JT, Doh J PloS one 24632942 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24632942
HIV protease inhibitors block streptolysin S production. Maxson T, Deane CD, Molloy EM, Cox CL, Markley AL, Lee SW, Mitchell DA ACS chemical biology 25668590 ACS Chem Biol 2015 May 15 https://www.ncbi.nlm.nih.gov/pubmed/25668590
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin-4(3H)-one derivatives as potential aldose reductase inhibitors. Tokalı FS, Demir Y, Demircioğlu İH, Türkeş C, Kalay E, Şendil K, Beydemir Ş Drug development research 34585414 Drug Dev Res 2022 May https://www.ncbi.nlm.nih.gov/pubmed/34585414
Using bacterial genomes and essential genes for the development of new antibiotics. Fields FR, Lee SW, McConnell MJ Biochemical pharmacology 27940263 Biochem Pharmacol 2017 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/27940263
Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics. Kane TL, Carothers KE, Lee SW Current drug targets 27894236 Curr Drug Targets 2018 https://www.ncbi.nlm.nih.gov/pubmed/27894236
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains. Fields FR, Freed SD, Carothers KE, Hamid MN, Hammers DE, Ross JN, Kalwajtys VR, Gonzalez AJ, Hildreth AD, Friedberg I, Lee SW Drug development research 31483516 Drug Dev Res 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31483516
Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells. Flaherty RA, Lee SW Journal of visualized experiments : JoVE 27585035 J Vis Exp 2016 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/27585035
CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants. Bao YJ, Liang Z, Mayfield JA, Lee SW, Ploplis VA, Castellino FJ Journal of bacteriology 26216843 J Bacteriol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26216843
Knowing is half the battle: targeting virulence factors of group A Streptococcus for vaccine and therapeutics. Thomas CL, Lee SW Current drug targets 22206254 Curr Drug Targets 2012 Mar https://www.ncbi.nlm.nih.gov/pubmed/22206254
Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties. Corman HN, Ross JN, Fields FR, Shoue DA, McDowell MA, Lee SW Microbiology spectrum 36342284 Microbiol Spectr 2022 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/36342284
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48. Fields FR, Carothers KE, Balsara RD, Ploplis VA, Castellino FJ, Lee SW The Journal of antibiotics 29463889 J Antibiot (Tokyo) 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29463889
Design and evaluation of a peptide-based immunotoxin for breast cancer therapeutics. Weigel KJ, Shen L, Thomas CL, Alber D, Drapalik L, Schafer ZT, Lee SW FEBS open bio 25853036 FEBS Open Bio 2015 https://www.ncbi.nlm.nih.gov/pubmed/25853036
Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution. Vu HM, Hammers DE, Liang Z, Nguyen GL, Benz ME, Moran TE, Higashi DL, Park CJ, Ayinuola YA, Donahue DL, Flores-Mireles AL, Ploplis VA, Castellino FJ, Lee SW Frontiers in cardiovascular medicine 34179133 Front Cardiovasc Med 2021 https://www.ncbi.nlm.nih.gov/pubmed/34179133
Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection. Flaherty RA, Puricelli JM, Higashi DL, Park CJ, Lee SW Infection and immunity 26238711 Infect Immun 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26238711
Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection. Flaherty RA, Donahue DL, Carothers KE, Ross JN, Ploplis VA, Castellino FJ, Lee SW Frontiers in cellular and infection microbiology 30018884 Front Cell Infect Microbiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30018884
A multiparametric computational algorithm for comprehensive assessment of genetic mutations in mucopolysaccharidosis type IIIA (Sanfilippo syndrome). Ugrinov KG, Freed SD, Thomas CL, Lee SW PloS one 25807448 PLoS One 2015 https://www.ncbi.nlm.nih.gov/pubmed/25807448
A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins. Morton JT, Freed SD, Lee SW, Friedberg I BMC bioinformatics 26558535 BMC Bioinformatics 2015 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/26558535
The wide world of ribosomally encoded bacterial peptides. Flaherty RA, Freed SD, Lee SW PLoS pathogens 25079075 PLoS Pathog 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/25079075
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Streptolysin S-like virulence factors: the continuing sagA. Molloy EM, Cotter PD, Hill C, Mitchell DA, Ross RP Nature reviews. Microbiology 21822292 Nat Rev Microbiol 2011 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/21822292
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA Natural product reports 23165928 Nat Prod Rep 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23165928
Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete. Metelev M, Tietz JI, Melby JO, Blair PM, Zhu L, Livnat I, Severinov K, Mitchell DA Chemistry & biology 25601074 Chem Biol 2015 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/25601074
Head-to-Head Prenyl Synthases in Pathogenic Bacteria. Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E Chembiochem : a European journal of chemical biology 28340291 Chembiochem 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28340291
Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase. Melby JO, Dunbar KL, Trinh NQ, Mitchell DA Journal of the American Chemical Society 22401305 J Am Chem Soc 2012 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/22401305
Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide. Maxson T, Bertke JA, Gray DL, Mitchell DA Acta crystallographica. Section E, Crystallographic communications 26594520 Acta Crystallogr E Crystallogr Commun 2015 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/26594520
In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin. Hudson GA, Zhang Z, Tietz JI, Mitchell DA, van der Donk WA Journal of the American Chemical Society 26675417 J Am Chem Soc 2015 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/26675417
A new genome-mining tool redefines the lasso peptide biosynthetic landscape. Tietz JI, Schwalen CJ, Patel PS, Maxson T, Blair PM, Tai HC, Zakai UI, Mitchell DA Nature chemical biology 28244986 Nat Chem Biol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28244986
Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics. Maxson T, Mitchell DA Tetrahedron 27429480 Tetrahedron 2016 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/27429480
In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products. Deane CD, Burkhart BJ, Saint-Vincent PMB, Tietz JI, Lin A, Mitchell DA ACS chemical biology 27248686 ACS Chem Biol 2016 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/27248686
Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA Proceedings of the National Academy of Sciences of the United States of America 23878226 Proc Natl Acad Sci U S A 2013 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/23878226
Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase. Sharma A, Saint-Vincent PMB, Mitchell DA Organic letters 24063702 Org Lett 2013 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/24063702
YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations. Dunbar KL, Melby JO, Mitchell DA Nature chemical biology 22522320 Nat Chem Biol 2012 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/22522320
Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Molloy EM, Tietz JI, Blair PM, Mitchell DA Bioorganic & medicinal chemistry 27234886 Bioorg Med Chem 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27234886
Nucleophilic 1,4-additions for natural product discovery. Cox CL, Tietz JI, Sokolowski K, Melby JO, Doroghazi JR, Mitchell DA ACS chemical biology 24937678 ACS Chem Biol 2014 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/24937678
Multitarget drug discovery for tuberculosis and other infectious diseases. Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E Journal of medicinal chemistry 24568559 J Med Chem 2014 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/24568559
Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads. Sinko W, Wang Y, Zhu W, Zhang Y, Feixas F, Cox CL, Mitchell DA, Oldfield E, McCammon JA Journal of medicinal chemistry 24827744 J Med Chem 2014 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/24827744
Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family. Molloy EM, Casjens SR, Cox CL, Maxson T, Ethridge NA, Margos G, Fingerle V, Mitchell DA BMC microbiology 26204951 BMC Microbiol 2015 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/26204951
Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. Deane CD, Mitchell DA Journal of industrial microbiology & biotechnology 24142337 J Ind Microbiol Biotechnol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24142337
Engineering unnatural variants of plantazolicin through codon reprogramming. Deane CD, Melby JO, Molohon KJ, Susarrey AR, Mitchell DA ACS chemical biology 23823732 ACS Chem Biol 2013 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/23823732
Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates. Melby JO, Nard NJ, Mitchell DA Current opinion in chemical biology 21429787 Curr Opin Chem Biol 2011 Jun https://www.ncbi.nlm.nih.gov/pubmed/21429787
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E ACS medicinal chemistry letters 22662288 ACS Med Chem Lett 2012 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/22662288
Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin. Hao Y, Saint-Vincent PMB, Sharma A, Mitchell DA, Nair SK ACS chemical biology 25635336 ACS Chem Biol 2015 May 15 https://www.ncbi.nlm.nih.gov/pubmed/25635336
Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins. Maxson T, Tietz JI, Hudson GA, Guo XR, Tai HC, Mitchell DA Journal of the American Chemical Society 27797509 J Am Chem Soc 2016 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/27797509
The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles. Cox CL, Doroghazi JR, Mitchell DA BMC genomics 26462797 BMC Genomics 2015 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/26462797
YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function. Burkhart BJ, Schwalen CJ, Mann G, Naismith JH, Mitchell DA Chemical reviews 28256131 Chem Rev 2017 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/28256131
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2. Erdemli SB, Gupta R, Bishai WR, Lamichhane G, Amzel LM, Bianchet MA Structure (London, England : 1993) 23103390 Structure 2012 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/23103390
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Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development. Moraes GL, Gomes GC, Monteiro de Sousa PR, Alves CN, Govender T, Kruger HG, Maguire GE, Lamichhane G, Lameira J Tuberculosis (Edinburgh, Scotland) 25701501 Tuberculosis (Edinb) 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25701501
Ldt(Mav2), a nonclassical transpeptidase and susceptibility of Mycobacterium avium to carbapenems. Mattoo R, Lloyd EP, Kaushik A, Kumar P, Brunelle JL, Townsend CA, Lamichhane G Future microbiology 28555497 Future Microbiol 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28555497
In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis. Kaushik A, Ammerman NC, Tasneen R, Story-Roller E, Dooley KE, Dorman SE, Nuermberger EL, Lamichhane G The Journal of antimicrobial chemotherapy 28575382 J Antimicrob Chemother 2017 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/28575382
Carbapenems against Mycobacterium tuberculosis: a review of the evidence. Jaganath D, Lamichhane G, Shah M The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 27776583 Int J Tuberc Lung Dis 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27776583
Carbapenems and Rifampin Exhibit Synergy against Mycobacterium tuberculosis and Mycobacterium abscessus. Kaushik A, Makkar N, Pandey P, Parrish N, Singh U, Lamichhane G Antimicrobial agents and chemotherapy 26259792 Antimicrob Agents Chemother 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26259792
Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis. Brammer Basta LA, Ghosh A, Pan Y, Jakoncic J, Lloyd EP, Townsend CA, Lamichhane G, Bianchet MA The Journal of biological chemistry 26304120 J Biol Chem 2015 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/26304120
Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis. Wang X, Perryman AL, Li SG, Paget SD, Stratton TP, Lemenze A, Olson AJ, Ekins S, Kumar P, Freundlich JS ACS infectious diseases 31625383 ACS Infect Dis 2019 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/31625383
A screen for non-coding RNA in Mycobacterium tuberculosis reveals a cAMP-responsive RNA that is expressed during infection. Pelly S, Bishai WR, Lamichhane G Gene 22446041 Gene 2012 May 25 https://www.ncbi.nlm.nih.gov/pubmed/22446041
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Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis. Makafe GG, Cao Y, Tan Y, Julius M, Liu Z, Wang C, Njire MM, Cai X, Liu T, Wang B, Pang W, Tan S, Zhang B, Yew WW, Lamichhane G, Guo J, Zhang T Antimicrobial agents and chemotherapy 26953211 Antimicrob Agents Chemother 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26953211
Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis. Njire M, Wang N, Wang B, Tan Y, Cai X, Liu Y, Mugweru J, Guo J, Hameed HMA, Tan S, Liu J, Yew WW, Nuermberger E, Lamichhane G, Liu J, Zhang T Antimicrobial agents and chemotherapy 28438933 Antimicrob Agents Chemother 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28438933
Non-classical transpeptidases yield insight into new antibacterials. Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Ammerman NC, Bell DT, Perryman AL, Zandi TA, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G Nature chemical biology 27820797 Nat Chem Biol 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/27820797
A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA. Perryman AL, Yu W, Wang X, Ekins S, Forli S, Li SG, Freundlich JS, Tonge PJ, Olson AJ Journal of chemical information and modeling 25636146 J Chem Inf Model 2015 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/25636146
Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt(Mt2) by biapenem and tebipenem. Bianchet MA, Pan YH, Basta LAB, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G BMC biochemistry 28545389 BMC Biochem 2017 May 25 https://www.ncbi.nlm.nih.gov/pubmed/28545389
Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins. Kumar P, Chauhan V, Silva JRA, Lameira J, d'Andrea FB, Li SG, Ginell SL, Freundlich JS, Alves CN, Bailey S, Cohen KA, Lamichhane G Antimicrobial agents and chemotherapy 28760902 Antimicrob Agents Chemother 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28760902
Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2. Silva JR, Bishai WR, Govender T, Lamichhane G, Maguire GE, Kruger HG, Lameira J, Alves CN Journal of biomolecular structure & dynamics 25762064 J Biomol Struct Dyn 2016 https://www.ncbi.nlm.nih.gov/pubmed/25762064
Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams. Schoonmaker MK, Bishai WR, Lamichhane G Journal of bacteriology 24464457 J Bacteriol 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24464457
Pooled ChIP-Seq Links Variation in Transcription Factor Binding to Complex Disease Risk. Tehranchi AK, Myrthil M, Martin T, Hie BL, Golan D, Fraser HB Cell 27087447 Cell 2016 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/27087447
Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR Cell metabolism 24703700 Cell Metab 2014 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/24703700
Doxycycline alters metabolism and proliferation of human cell lines. Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR PloS one 23741339 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/23741339
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Krall AS, Xu S, Graeber TG, Braas D, Christofk HR Nature communications 27126896 Nat Commun 2016 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/27126896
Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR Cancer discovery 23230188 Cancer Discov 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/23230188
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication. Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR Nature communications 26561297 Nat Commun 2015 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/26561297
MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR Cell reports 26876179 Cell Rep 2016 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/26876179
Social interaction, noise and antibiotic-mediated switches in the intestinal microbiota. Bucci V, Bradde S, Biroli G, Xavier JB PLoS computational biology 22577356 PLoS Comput Biol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22577356
The ecological basis of morphogenesis: branching patterns in swarming colonies of bacteria. Deng P, de Vargas Roditi L, van Ditmarsch D, Xavier JB New journal of physics 24587694 New J Phys 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/24587694
Convergent evolution of hyperswarming leads to impaired biofilm formation in pathogenic bacteria. van Ditmarsch D, Boyle KE, Sakhtah H, Oyler JE, Nadell CD, Déziel É, Dietrich LE, Xavier JB Cell reports 23954787 Cell Rep 2013 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/23954787
Sociomicrobiology and Pathogenic Bacteria. Xavier JB Microbiology spectrum 27337482 Microbiol Spectr 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27337482
Tumour-stromal interactions generate emergent persistence in collective cancer cell migration. Chang WK, Carmona-Fontaine C, Xavier JB Interface focus 24511381 Interface Focus 2013 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/24511381
Turning ecology and evolution against cancer. Korolev KS, Xavier JB, Gore J Nature reviews. Cancer 24739582 Nat Rev Cancer 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24739582
Towards predictive models of the human gut microbiome. Bucci V, Xavier JB Journal of molecular biology 24727124 J Mol Biol 2014 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/24727124
Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Taur Y, Xavier JB, Lipuma L, Ubeda C, Goldberg J, Gobourne A, Lee YJ, Dubin KA, Socci ND, Viale A, Perales MA, Jenq RR, van den Brink MR, Pamer EG Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 22718773 Clin Infect Dis 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22718773
Multilevel selection analysis of a microbial social trait. de Vargas Roditi L, Boyle KE, Xavier JB Molecular systems biology 23959025 Mol Syst Biol 2013 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/23959025
Facultative control of matrix production optimizes competitive fitness in Pseudomonas aeruginosa PA14 biofilm models. Madsen JS, Lin YC, Squyres GR, Price-Whelan A, de Santiago Torio A, Song A, Cornell WC, Sørensen SJ, Xavier JB, Dietrich LE Applied and environmental microbiology 26431965 Appl Environ Microbiol 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26431965
Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Wexler AG, Bao Y, Whitney JC, Bobay LM, Xavier JB, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD, Goodman AL Proceedings of the National Academy of Sciences of the United States of America 26957597 Proc Natl Acad Sci U S A 2016 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/26957597
Metabolism and the Evolution of Social Behavior. Boyle KE, Monaco HT, Deforet M, Yan J, Wang Z, Rhee K, Xavier JB Molecular biology and evolution 28595344 Mol Biol Evol 2017 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/28595344
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, No D, Liu H, Kinnebrew M, Viale A, Littmann E, van den Brink MR, Jenq RR, Taur Y, Sander C, Cross JR, Toussaint NC, Xavier JB, Pamer EG Nature 25337874 Nature 2015 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/25337874
Hyperswarming adaptations in a bacterium improve collective motility without enhancing single cell motility. Deforet M, van Ditmarsch D, Carmona-Fontaine C, Xavier JB Soft matter 24622509 Soft Matter 2014 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/24622509
Integration of Metabolic and Quorum Sensing Signals Governing the Decision to Cooperate in a Bacterial Social Trait. Boyle KE, Monaco H, van Ditmarsch D, Deforet M, Xavier JB PLoS computational biology 26102206 PLoS Comput Biol 2015 May https://www.ncbi.nlm.nih.gov/pubmed/26102206
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect. Carmona-Fontaine C, Bucci V, Akkari L, Deforet M, Joyce JA, Xavier JB Proceedings of the National Academy of Sciences of the United States of America 24218566 Proc Natl Acad Sci U S A 2013 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/24218566
Cutting through the complexity of cell collectives. Nadell CD, Bucci V, Drescher K, Levin SA, Bassler BL, Xavier JB Proceedings. Biological sciences 23363630 Proc Biol Sci 2013 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/23363630
Exploiting social evolution in biofilms. Boyle KE, Heilmann S, van Ditmarsch D, Xavier JB Current opinion in microbiology 23357558 Curr Opin Microbiol 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23357558
Cell-Size Homeostasis and the Incremental Rule in a Bacterial Pathogen. Deforet M, van Ditmarsch D, Xavier JB Biophysical journal 26244734 Biophys J 2015 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/26244734
Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota. Stein RR, Bucci V, Toussaint NC, Buffie CG, Rätsch G, Pamer EG, Sander C, Xavier JB PLoS computational biology 24348232 PLoS Comput Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/24348232
Digital and analog gene circuits for biotechnology. Roquet N, Lu TK Biotechnology journal 24677719 Biotechnol J 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24677719
Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics. Cheng AA, Ding H, Lu TK Proceedings of the National Academy of Sciences of the United States of America 25114216 Proc Natl Acad Sci U S A 2014 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/25114216
Synthetic biology. Genomically encoded analog memory with precise in vivo DNA writing in living cell populations. Farzadfard F, Lu TK Science (New York, N.Y.) 25395541 Science 2014 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/25395541
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Citorik RJ, Mimee M, Lu TK Nature biotechnology 25240928 Nat Biotechnol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25240928
DNA nanotechnology: new adventures for an old warhorse. Zakeri B, Lu TK Current opinion in chemical biology 26056949 Curr Opin Chem Biol 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26056949
Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing. Ando H, Lemire S, Pires DP, Lu TK Cell systems 26973885 Cell Syst 2015 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/26973885
Genetically Engineered Phages: a Review of Advances over the Last Decade. Pires DP, Cleto S, Sillankorva S, Azeredo J, Lu TK Microbiology and molecular biology reviews : MMBR 27250768 Microbiol Mol Biol Rev 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27250768
Rule-based design of synthetic transcription factors in eukaryotes. Purcell O, Peccoud J, Lu TK ACS synthetic biology 24933274 ACS Synth Biol 2014 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/24933274
Engineering living functional materials. Chen AY, Zhong C, Lu TK ACS synthetic biology 25592034 ACS Synth Biol 2015 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/25592034
Single-molecule detection of protein efflux from microorganisms using fluorescent single-walled carbon nanotube sensor arrays. Landry MP, Ando H, Chen AY, Cao J, Kottadiel VI, Chio L, Yang D, Dong J, Lu TK, Strano MS Nature nanotechnology 28114298 Nat Nanotechnol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28114298
Synthetic recombinase-based state machines in living cells. Roquet N, Soleimany AP, Ferris AC, Aaronson S, Lu TK Science (New York, N.Y.) 27463678 Science 2016 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/27463678
Synthetic mixed-signal computation in living cells. Rubens JR, Selvaggio G, Lu TK Nature communications 27255669 Nat Commun 2016 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/27255669
Multiplexed Sequence Encoding: A Framework for DNA Communication. Zakeri B, Carr PA, Lu TK PloS one 27050646 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27050646
Strong underwater adhesives made by self-assembling multi-protein nanofibres. Zhong C, Gurry T, Cheng AA, Downey J, Deng Z, Stultz CM, Lu TK Nature nanotechnology 25240674 Nat Nanotechnol 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25240674
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. Farzadfard F, Perli SD, Lu TK ACS synthetic biology 23977949 ACS Synth Biol 2013 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/23977949
Synthesis and patterning of tunable multiscale materials with engineered cells. Chen AY, Deng Z, Billings AN, Seker UO, Lu MY, Citorik RJ, Zakeri B, Lu TK Nature materials 24658114 Nat Mater 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24658114
Synthetic analog and digital circuits for cellular computation and memory. Purcell O, Lu TK Current opinion in biotechnology 24794536 Curr Opin Biotechnol 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24794536
Bacteriophage-based synthetic biology for the study of infectious diseases. Citorik RJ, Mimee M, Lu TK Current opinion in microbiology 24997401 Curr Opin Microbiol 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24997401
Enhancing phage therapy through synthetic biology and genome engineering. Lenneman BR, Fernbach J, Loessner MJ, Lu TK, Kilcher S Current opinion in biotechnology 33310655 Curr Opin Biotechnol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33310655
Hydrogel-based biocontainment of bacteria for continuous sensing and computation. Tang TC, Tham E, Liu X, Yehl K, Rovner AJ, Yuk H, de la Fuente-Nunez C, Isaacs FJ, Zhao X, Lu TK Nature chemical biology 33820990 Nat Chem Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33820990
Gene networks that compensate for crosstalk with crosstalk. Müller IE, Rubens JR, Jun T, Graham D, Xavier R, Lu TK Nature communications 31492904 Nat Commun 2019 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/31492904
Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis. Yehl K, Lemire S, Yang AC, Ando H, Mimee M, Torres MT, de la Fuente-Nunez C, Lu TK Cell 31585083 Cell 2019 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/31585083
Towards a whole-cell modeling approach for synthetic biology. Purcell O, Jain B, Karr JR, Covert MW, Lu TK Chaos (Woodbury, N.Y.) 23822510 Chaos 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23822510
Complete Genome Sequence of Pseudomonas aeruginosa Phage vB_PaeM_CEB_DP1. Pires DP, Sillankorva S, Kropinski AM, Lu TK, Azeredo J Genome announcements 26404589 Genome Announc 2015 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/26404589
Synthetic Biogenesis of Bacterial Amyloid Nanomaterials with Tunable Inorganic-Organic Interfaces and Electrical Conductivity. Seker UO, Chen AY, Citorik RJ, Lu TK ACS synthetic biology 27794590 ACS Synth Biol 2017 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/27794590
Microbiome therapeutics - Advances and challenges. Mimee M, Citorik RJ, Lu TK Advanced drug delivery reviews 27158095 Adv Drug Deliv Rev 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27158095
Massively parallel high-order combinatorial genetics in human cells. Wong AS, Choi GC, Cheng AA, Purcell O, Lu TK Nature biotechnology 26280411 Nat Biotechnol 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26280411
A Modular Toolkit for Generating Pichia pastoris Secretion Libraries. Obst U, Lu TK, Sieber V ACS synthetic biology 28252957 ACS Synth Biol 2017 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/28252957
Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells. Nissim L, Perli SD, Fridkin A, Perez-Pinera P, Lu TK Molecular cell 24837679 Mol Cell 2014 May 22 https://www.ncbi.nlm.nih.gov/pubmed/24837679
A synthetic biology framework for programming eukaryotic transcription functions. Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, Joung JK, Collins JJ Cell 22863014 Cell 2012 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/22863014
Synthetic biology: an emerging engineering discipline. Cheng AA, Lu TK Annual review of biomedical engineering 22577777 Annu Rev Biomed Eng 2012 https://www.ncbi.nlm.nih.gov/pubmed/22577777
Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. Radovic-Moreno AF, Lu TK, Puscasu VA, Yoon CJ, Langer R, Farokhzad OC ACS nano 22471841 ACS Nano 2012 May 22 https://www.ncbi.nlm.nih.gov/pubmed/22471841
Advancing bacteriophage-based microbial diagnostics with synthetic biology. Lu TK, Bowers J, Koeris MS Trends in biotechnology 23608522 Trends Biotechnol 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23608522
Synthetic biology of antimicrobial discovery. Zakeri B, Lu TK ACS synthetic biology 23654251 ACS Synth Biol 2013 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/23654251
Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi). Cleto S, Jensen JV, Wendisch VF, Lu TK ACS synthetic biology 26829286 ACS Synth Biol 2016 May 20 https://www.ncbi.nlm.nih.gov/pubmed/26829286
Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota. Mimee M, Tucker AC, Voigt CA, Lu TK Cell systems 26918244 Cell Syst 2015 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/26918244
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. Wong AS, Choi GC, Cui CH, Pregernig G, Milani P, Adam M, Perli SD, Kazer SW, Gaillard A, Hermann M, Shalek AK, Fraenkel E, Lu TK Proceedings of the National Academy of Sciences of the United States of America 26864203 Proc Natl Acad Sci U S A 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26864203
Foundations and Emerging Paradigms for Computing in Living Cells. Ma KC, Perli SD, Lu TK Journal of molecular biology 26908220 J Mol Biol 2016 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/26908220
Engineering genetic circuits that compute and remember. Siuti P, Yazbek J, Lu TK Nature protocols 24810038 Nat Protoc 2014 https://www.ncbi.nlm.nih.gov/pubmed/24810038
Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica. Cleto S, Haslinger K, Prather KLJ, Lu TK BMC biology 33722216 BMC Biol 2021 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/33722216
Full-colour Jabuticaba-like nanostructures via the multiplex and orthogonal self-assembly of protein-conjugated quantum dots with engineered biofilms. Deng Z, Chen AY, Zakeri B, Zhong C, Lu TK Materials horizons 36786820 Mater Horiz 2023 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/36786820
Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks. Leland BA, Chen AC, Zhao AY, Wharton RC, King MC eLife 29697047 Elife 2018 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/29697047
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe. Laffitte A, Lin D, Tian YJ, Liu N, Lusk CP, Mochrie SGJ, King MC Genes & development 41436280 Genes Dev 2026 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/41436280
A quality control mechanism linking meiotic success to release of ascospores. Guo H, King MC PloS one 24312672 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24312672
A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity. King MC, Lusk CP Current opinion in cell biology 27031045 Curr Opin Cell Biol 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27031045
TERRA promotes telomerase-mediated telomere elongation in Schizosaccharomyces pombe. Moravec M, Wischnewski H, Bah A, Hu Y, Liu N, Lafranchi L, King MC, Azzalin CM EMBO reports 27154402 EMBO Rep 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27154402
RNA-DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast. Hu Y, Bennett HW, Liu N, Moravec M, Williams JF, Azzalin CM, King MC Genetics 31405990 Genetics 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31405990
The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. Wälde S, King MC Journal of cell science 24963130 J Cell Sci 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24963130
The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in S. pombe. Laffitte A, Lin D, Tian YJ, Liu N, Lusk CP, Mochrie SGJ, King MC bioRxiv : the preprint server for biology 41278860 bioRxiv 2025 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/41278860
Improved Determination of Subnuclear Position Enabled by Three-Dimensional Membrane Reconstruction. Zhao Y, Schreiner SM, Koo PK, Colombi P, King MC, Mochrie SG Biophysical journal 27410730 Biophys J 2016 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/27410730
TeloPCR-seq: a high-throughput sequencing approach for telomeres. Bennett HW, Liu N, Hu Y, King MC FEBS letters 27714790 FEBS Lett 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27714790
Forces, fluctuations, and self-organization in the nucleus. Pederson T, King MC, Marko JF Molecular biology of the cell 26543199 Mol Biol Cell 2015 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/26543199
A role for nuclear envelope-bridging complexes in homology-directed repair. Swartz RK, Rodriguez EC, King MC Molecular biology of the cell 24943839 Mol Biol Cell 2014 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/24943839
Applying superresolution localization-based microscopy to neurons. Zhong H Synapse (New York, N.Y.) 25648102 Synapse 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25648102
Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database. Duchman KR, Gao Y, Miller BJ Cancer epidemiology 26002013 Cancer Epidemiol 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26002013
Vending Assessment and Program Implementation in Four Iowa Worksites. Lillehoj CJ, Nothwehr F, Shipley K, Voss C Health promotion practice 26220278 Health Promot Pract 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26220278
Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices. Do AV, Worthington KS, Tucker BA, Salem AK International journal of pharmaceutics 30268853 Int J Pharm 2018 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/30268853
Structural and biochemical analyses of choroidal thickness in human donor eyes. Sohn EH, Khanna A, Tucker BA, Abràmoff MD, Stone EM, Mullins RF Investigative ophthalmology & visual science 24519422 Invest Ophthalmol Vis Sci 2014 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/24519422
Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Baranov PY, Tucker BA, Young MJ Tissue engineering. Part A 24320879 Tissue Eng Part A 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24320879
Photoreceptor cells with profound structural deficits can support useful vision in mice. Thompson S, Blodi FR, Lee S, Welder CR, Mullins RF, Tucker BA, Stasheff SF, Stone EM Investigative ophthalmology & visual science 24569582 Invest Ophthalmol Vis Sci 2014 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/24569582
Stem cells for investigation and treatment of inherited retinal disease. Tucker BA, Mullins RF, Stone EM Human molecular genetics 24647603 Hum Mol Genet 2014 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/24647603
ABCB5 is a limbal stem cell gene required for corneal development and repair. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY Nature 25030174 Nature 2014 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/25030174
Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration. Zeng S, Whitmore SS, Sohn EH, Riker MJ, Wiley LA, Scheetz TE, Stone EM, Tucker BA, Mullins RF The Journal of pathology 26564985 J Pathol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26564985
Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC Human molecular genetics 26494905 Hum Mol Genet 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26494905
Influence of a loop electrosurgical excision procedure (LEEP) on levels of cytokines in cervical secretions. Saftlas AF, Spracklen CN, Ryckman KK, Stockdale CK, Penrose K, Ault K, Rubenstein LM, Pinto LA Journal of reproductive immunology 25721621 J Reprod Immunol 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25721621
Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate. Worthington KS, Do AV, Smith R, Tucker BA, Salem AK Macromolecular bioscience 30430755 Macromol Biosci 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30430755
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness. Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, Penticoff JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA Scientific reports 27471043 Sci Rep 2016 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/27471043
Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa. Tucker BA, Scheetz TE, Mullins RF, DeLuca AP, Hoffmann JM, Johnston RM, Jacobson SG, Sheffield VC, Stone EM Proceedings of the National Academy of Sciences of the United States of America 21825139 Proc Natl Acad Sci U S A 2011 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/21825139
Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation. Tucker BA, Anfinson KR, Mullins RF, Stone EM, Young MJ Stem cells translational medicine 23283489 Stem Cells Transl Med 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23283489
Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial. Tucker BA, Cranston CM, Anfinson KA, Shrestha S, Streb LM, Leon A, Mullins RF, Stone EM Translational research : the journal of laboratory and clinical medicine 26364624 Transl Res 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26364624
Risk of recurrent preterm birth among women according to change in partner. Baer RJ, Yang J, Chambers CD, Ryckman KK, Saftlas AF, Berghella V, Schetter CD, Shaw GM, Stevenson DK, Jelliffe-Pawlowski LL Journal of perinatal medicine 27718495 J Perinat Med 2017 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/27718495
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration. Songstad AE, Wiley LA, Duong K, Kaalberg E, Flamme-Wiese MJ, Cranston CM, Riker MJ, Levasseur D, Stone EM, Mullins RF, Tucker BA Investigative ophthalmology & visual science 26720480 Invest Ophthalmol Vis Sci 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26720480
Intravesical and alternative bladder-preservation therapies in the management of non-muscle-invasive bladder cancer unresponsive to bacillus Calmette-Guérin. Steinberg RL, Thomas LJ, Nepple KG Urologic oncology 26777259 Urol Oncol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26777259
Sources of bias in peoples' social-comparative estimates of food consumption. Scherer AM, Bruchmann K, Windschitl PD, Rose JP, Smith AR, Koestner B, Snetselaar L, Suls J Journal of experimental psychology. Applied 27054551 J Exp Psychol Appl 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27054551
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells. Ozden O, Park SH, Wagner BA, Song HY, Zhu Y, Vassilopoulos A, Jung B, Buettner GR, Gius D Free radical biology & medicine 25152236 Free Radic Biol Med 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25152236
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease. Giacalone JC, Wiley LA, Burnight ER, Songstad AE, Mullins RF, Stone EM, Tucker BA Stem cells translational medicine 26683869 Stem Cells Transl Med 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26683869
Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds. Worthington KS, Wiley LA, Guymon CA, Salem AK, Tucker BA Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 26692377 J Ocul Pharmacol Ther 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26692377
Stem cells as tools for studying the genetics of inherited retinal degenerations. Wiley LA, Burnight ER, Mullins RF, Stone EM, Tucker BA Cold Spring Harbor perspectives in medicine 25502747 Cold Spring Harb Perspect Med 2014 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/25502747
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy. Whitmore SS, Sohn EH, Chirco KR, Drack AV, Stone EM, Tucker BA, Mullins RF Progress in retinal and eye research 25486088 Prog Retin Eye Res 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25486088
Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy. Boye SE, Huang WC, Roman AJ, Sumaroka A, Boye SL, Ryals RC, Olivares MB, Ruan Q, Tucker BA, Stone EM, Swaroop A, Cideciyan AV, Hauswirth WW, Jacobson SG PloS one 24671090 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24671090
CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype. Burnight ER, Wiley LA, Drack AV, Braun TA, Anfinson KR, Kaalberg EE, Halder JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA Gene therapy 24807808 Gene Ther 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24807808
Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study. Sohn EH, Jiao C, Kaalberg E, Cranston C, Mullins RF, Stone EM, Tucker BA Scientific reports 26138532 Sci Rep 2015 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/26138532
Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases. Wiley LA, Burnight ER, Songstad AE, Drack AV, Mullins RF, Stone EM, Tucker BA Progress in retinal and eye research 25448922 Prog Retin Eye Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25448922
Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis. Drivas TG, Wojno AP, Tucker BA, Stone EM, Bennett J Science translational medicine 26062849 Sci Transl Med 2015 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/26062849
Weight loss after head and neck cancer: A dynamic relationship with depressive symptoms. Van Liew JR, Brock RL, Christensen AJ, Karnell LH, Pagedar NA, Funk GF Head & neck 27704695 Head Neck 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/27704695
Perception of patient appearance following various methods of reconstruction after orbital exenteration. Kuiper JJ, Zimmerman MB, Pagedar NA, Carter KD, Allen RC, Shriver EM Orbit (Amsterdam, Netherlands) 27341072 Orbit 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/27341072
Loss of CD34 expression in aging human choriocapillaris endothelial cells. Sohn EH, Flamme-Wiese MJ, Whitmore SS, Wang K, Tucker BA, Mullins RF PloS one 24466138 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24466138
Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012. Khaja SF, Hoffman HT, Pagedar NA The Annals of otology, rhinology, and laryngology 26481178 Ann Otol Rhinol Laryngol 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26481178
Use of the Teres Major Muscle in Chimeric Subscapular System Free Flaps for Head and Neck Reconstruction. Tomlinson AR, Jameson MJ, Pagedar NA, Schoeff SS, Shearer AE, Boyd NH JAMA otolaryngology-- head & neck surgery 26312435 JAMA Otolaryngol Head Neck Surg 2015 Sep https://www.ncbi.nlm.nih.gov/pubmed/26312435
A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids. Wiley LA, Beebe DC, Mullins RF, Stone EM, Tucker BA Current protocols in stem cell biology 27171793 Curr Protoc Stem Cell Biol 2016 May 12 https://www.ncbi.nlm.nih.gov/pubmed/27171793
Prevascularized silicon membranes for the enhancement of transport to implanted medical devices. Worthington KS, Wiley LA, Mullins RF, Tucker BA, Nuxoll E Journal of biomedical materials research. Part B, Applied biomaterials 26316050 J Biomed Mater Res B Appl Biomater 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/26316050
Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma. Tucker BA, Solivan-Timpe F, Roos BR, Anfinson KR, Robin AL, Wiley LA, Mullins RF, Fingert JH Journal of stem cell research & therapy 24883232 J Stem Cell Res Ther 2014 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/24883232
Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease. Braun TA, Mullins RF, Wagner AH, Andorf JL, Johnston RM, Bakall BB, Deluca AP, Fishman GA, Lam BL, Weleber RG, Cideciyan AV, Jacobson SG, Sheffield VC, Tucker BA, Stone EM Human molecular genetics 23918662 Hum Mol Genet 2013 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/23918662
Gene therapy using stem cells. Burnight ER, Wiley LA, Mullins RF, Stone EM, Tucker BA Cold Spring Harbor perspectives in medicine 25395375 Cold Spring Harb Perspect Med 2014 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/25395375
Wafer Scale Integration of CMOS Chips for Biomedical Applications via Self-Aligned Masking. Uddin A, Milaninia K, Chen CH, Theogarajan L IEEE transactions on components, packaging, and manufacturing technology 22400126 IEEE Trans Compon Packaging Manuf Technol 2011 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/22400126
Clickable Amphiphilic Triblock Copolymers. Isaacman MJ, Barron KA, Theogarajan LS Journal of polymer science. Part A, Polymer chemistry 23100856 J Polym Sci A Polym Chem 2012 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/23100856
Rapid Metal -free Macromolecular Coupling via in situ Nitrile Oxide-Activated Alkene Cycloaddition. Isaacman MJ, Cui W, Theogarajan LS Journal of polymer science. Part A, Polymer chemistry 26811566 J Polym Sci A Polym Chem 2014 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/26811566
Solid-state nanopore based biomimetic voltage gated ion channels. Pevarnik M, Cui W, Yemenicioglu S, Rofeh J, Theogarajan L Bioinspiration & biomimetics 28726670 Bioinspir Biomim 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/28726670
Integration of solid-state nanopores in a 0.5 μm CMOS foundry process. Uddin A, Yemenicioglu S, Chen CH, Corigliano E, Milaninia K, Theogarajan L Nanotechnology 23519330 Nanotechnology 2013 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/23519330
Stealth polymeric vesicles via metal-free click coupling. Isaacman MJ, Corigliano EM, Theogarajan LS Biomacromolecules 23952743 Biomacromolecules 2013 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/23952743
A CMOS enhanced solid-state nanopore based single molecule detection platform. Chen C, Yemenicioglu S, Uddin A, Corgliano E, Theogarajan L Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 24109650 Annu Int Conf IEEE Eng Med Biol Soc 2013 https://www.ncbi.nlm.nih.gov/pubmed/24109650
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Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD Stem cell reports 27569062 Stem Cell Reports 2016 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/27569062
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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J Nature chemical biology 21743462 Nat Chem Biol 2011 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/21743462
Revealing histone variant induced changes via quantitative proteomics. Arnaudo AM, Molden RC, Garcia BA Critical reviews in biochemistry and molecular biology 21526979 Crit Rev Biochem Mol Biol 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21526979
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O Molecular cell 22099308 Mol Cell 2011 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/22099308
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Van Aller GS, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos AF, McDevitt P, Sinnamon R, Le B, Mas G, Annan R, Sage J, Garcia BA, Tummino PJ, Gozani O, Kruger RG Epigenetics 22419068 Epigenetics 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22419068
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O Nature 24847881 Nature 2014 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/24847881
Middle-Down and Top-Down Mass Spectrometric Analysis of Co-occurring Histone Modifications. Molden RC, Garcia BA Current protocols in protein science 25081742 Curr Protoc Protein Sci 2014 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/25081742
Large-scale global identification of protein lysine methylation in vivo. Cao XJ, Arnaudo AM, Garcia BA Epigenetics 23644510 Epigenetics 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23644510
Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation. Cao XJ, Zee BM, Garcia BA Methods in molecular biology (Clifton, N.J.) 23436372 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23436372
Quantitative dynamics of the link between cellular metabolism and histone acetylation. Evertts AG, Zee BM, Dimaggio PA, Gonzales-Cope M, Coller HA, Garcia BA The Journal of biological chemistry 23482559 J Biol Chem 2013 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/23482559
Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Rothbart SB, Lin S, Britton LM, Krajewski K, Keogh MC, Garcia BA, Strahl BD Scientific reports 22761995 Sci Rep 2012 https://www.ncbi.nlm.nih.gov/pubmed/22761995
Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications. Molden RC, Bhanu NV, LeRoy G, Arnaudo AM, Garcia BA Epigenetics & chromatin 25922622 Epigenetics Chromatin 2015 https://www.ncbi.nlm.nih.gov/pubmed/25922622
EpiProfile Quantifies Histone Peptides With Modifications by Extracting Retention Time and Intensity in High-resolution Mass Spectra. Yuan ZF, Lin S, Molden RC, Cao XJ, Bhanu NV, Wang X, Sidoli S, Liu S, Garcia BA Molecular & cellular proteomics : MCP 25805797 Mol Cell Proteomics 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25805797
Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells. Gonzales-Cope M, Sidoli S, Bhanu NV, Won KJ, Garcia BA BMC genomics 26847871 BMC Genomics 2016 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/26847871
Quantitative proteomic analysis of histone modifications. Huang H, Lin S, Garcia BA, Zhao Y Chemical reviews 25688442 Chem Rev 2015 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/25688442
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW Science (New York, N.Y.) 27174990 Science 2016 May 13 https://www.ncbi.nlm.nih.gov/pubmed/27174990
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression. Jain SU, Khazaei S, Marchione DM, Lundgren SM, Wang X, Weinberg DN, Deshmukh S, Juretic N, Lu C, Allis CD, Garcia BA, Jabado N, Lewis PW Proceedings of the National Academy of Sciences of the United States of America 33067396 Proc Natl Acad Sci U S A 2020 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/33067396
Low Resolution Data-Independent Acquisition in an LTQ-Orbitrap Allows for Simplified and Fully Untargeted Analysis of Histone Modifications. Sidoli S, Simithy J, Karch KR, Kulej K, Garcia BA Analytical chemistry 26505526 Anal Chem 2015 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/26505526
Asymmetrically modified nucleosomes. Voigt P, LeRoy G, Drury WJ 3rd, Zee BM, Son J, Beck DB, Young NL, Garcia BA, Reinberg D Cell 23021224 Cell 2012 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/23021224
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD Science (New York, N.Y.) 23539183 Science 2013 May 17 https://www.ncbi.nlm.nih.gov/pubmed/23539183
Initial characterization of histone H3 serine 10 O-acetylation. Britton LM, Newhart A, Bhanu NV, Sridharan R, Gonzales-Cope M, Plath K, Janicki SM, Garcia BA Epigenetics 23949383 Epigenetics 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23949383
SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Binda O, Sevilla A, LeRoy G, Lemischka IR, Garcia BA, Richard S Epigenetics 23324626 Epigenetics 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23324626
Quantitative proteomic approaches to studying histone modifications. Zee BM, Young NL, Garcia BA Current chemical genomics 21966350 Curr Chem Genomics 2011 https://www.ncbi.nlm.nih.gov/pubmed/21966350
ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression. Ratnakumar K, Duarte LF, LeRoy G, Hasson D, Smeets D, Vardabasso C, Bönisch C, Zeng T, Xiang B, Zhang DY, Li H, Wang X, Hake SB, Schermelleh L, Garcia BA, Bernstein E Genes & development 22391447 Genes Dev 2012 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/22391447
Examining histone posttranslational modification patterns by high-resolution mass spectrometry. Lin S, Garcia BA Methods in enzymology 22910200 Methods Enzymol 2012 https://www.ncbi.nlm.nih.gov/pubmed/22910200
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF Nature 22722849 Nature 2012 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/22722849
Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation. Wu Y, DiMaggio PA Jr, Perlman DH, Zakian VA, Garcia BA Journal of proteome research 23181431 J Proteome Res 2013 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/23181431
H3R42me2a is a histone modification with positive transcriptional effects. Casadio F, Lu X, Pollock SB, LeRoy G, Garcia BA, Muir TW, Roeder RG, Allis CD Proceedings of the National Academy of Sciences of the United States of America 23980157 Proc Natl Acad Sci U S A 2013 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/23980157
Mass spectrometric analysis of histone proteoforms. Yuan ZF, Arnaudo AM, Garcia BA Annual review of analytical chemistry (Palo Alto, Calif.) 24896311 Annu Rev Anal Chem (Palo Alto Calif) 2014 https://www.ncbi.nlm.nih.gov/pubmed/24896311
Quantitative proteomic discovery of dynamic epigenome changes that control human cytomegalovirus (HCMV) infection. O'Connor CM, DiMaggio PA Jr, Shenk T, Garcia BA Molecular & cellular proteomics : MCP 24987098 Mol Cell Proteomics 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/24987098
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2. Garrigues JM, Sidoli S, Garcia BA, Strome S Genome research 25467431 Genome Res 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25467431
Bottom-up and middle-down proteomics have comparable accuracies in defining histone post-translational modification relative abundance and stoichiometry. Sidoli S, Lin S, Karch KR, Garcia BA Analytical chemistry 25719549 Anal Chem 2015 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/25719549
An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma'ayan A, Lemischka IR Frontiers in cell and developmental biology 33816475 Front Cell Dev Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/33816475
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW Nature communications 31086175 Nat Commun 2019 May 13 https://www.ncbi.nlm.nih.gov/pubmed/31086175
Global turnover of histone post-translational modifications and variants in human cells. Zee BM, Levin RS, DiMaggio PA, Garcia BA Epigenetics & chromatin 21134274 Epigenetics Chromatin 2010 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/21134274
The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Wu L, Zee BM, Wang Y, Garcia BA, Dou Y Molecular cell 21726816 Mol Cell 2011 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/21726816
Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Green EM, Mas G, Young NL, Garcia BA, Gozani O Nature structural & molecular biology 22343720 Nat Struct Mol Biol 2012 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/22343720
Comprehending dynamic protein methylation with mass spectrometry. Afjehi-Sadat L, Garcia BA Current opinion in chemical biology 23333572 Curr Opin Chem Biol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23333572
Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI Nature structural & molecular biology 23295261 Nat Struct Mol Biol 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23295261
Global secretome analysis identifies novel mediators of bone metastasis. Blanco MA, LeRoy G, Khan Z, Alečković M, Zee BM, Garcia BA, Kang Y Cell research 22688892 Cell Res 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22688892
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Chicas A, Kapoor A, Wang X, Aksoy O, Evertts AG, Zhang MQ, Garcia BA, Bernstein E, Lowe SW Proceedings of the National Academy of Sciences of the United States of America 22615382 Proc Natl Acad Sci U S A 2012 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/22615382
Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins. LeRoy G, Chepelev I, DiMaggio PA, Blanco MA, Zee BM, Zhao K, Garcia BA Genome biology 22897906 Genome Biol 2012 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/22897906
Combining genomic and proteomic approaches for epigenetics research. Han Y, Garcia BA Epigenomics 23895656 Epigenomics 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23895656
Proteomic characterization of novel histone post-translational modifications. Arnaudo AM, Garcia BA Epigenetics & chromatin 23916056 Epigenetics Chromatin 2013 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/23916056
Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations. Önder Ö, Sidoli S, Carroll M, Garcia BA Expert review of proteomics 26400466 Expert Rev Proteomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26400466
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, Hother C, Liu S, Cao XJ, Tam W, Shaknovich R, Garcia BA, Gascoyne RD, Ge K, Shilatifard A, Elemento O, Nussenzweig A, Melnick AM, Wendel HG Nature medicine 26366710 Nat Med 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26366710
Evaluation of proteomic search engines for the analysis of histone modifications. Yuan ZF, Lin S, Molden RC, Garcia BA Journal of proteome research 25167464 J Proteome Res 2014 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/25167464
Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression. Peixoto LL, Wimmer ME, Poplawski SG, Tudor JC, Kenworthy CA, Liu S, Mizuno K, Garcia BA, Zhang NR, Giese K, Abel T BMC genomics 26040834 BMC Genomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26040834
Complete Workflow for Analysis of Histone Post-translational Modifications Using Bottom-up Mass Spectrometry: From Histone Extraction to Data Analysis. Sidoli S, Bhanu NV, Karch KR, Wang X, Garcia BA Journal of visualized experiments : JoVE 27286567 J Vis Exp 2016 May 17 https://www.ncbi.nlm.nih.gov/pubmed/27286567
A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics. Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA Molecular & cellular proteomics : MCP 27114449 Mol Cell Proteomics 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/27114449
Characterization of BRD4 during mammalian postmeiotic sperm development. Bryant JM, Donahue G, Wang X, Meyer-Ficca M, Luense LJ, Weller AH, Bartolomei MS, Blobel GA, Meyer RG, Garcia BA, Berger SL Molecular and cellular biology 25691659 Mol Cell Biol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25691659
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE Cell metabolism 24998913 Cell Metab 2014 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/24998913
BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones. Kanno T, Kanno Y, LeRoy G, Campos E, Sun HW, Brooks SR, Vahedi G, Heightman TD, Garcia BA, Reinberg D, Siebenlist U, O'Shea JJ, Ozato K Nature structural & molecular biology 25383670 Nat Struct Mol Biol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25383670
High resolution is not a strict requirement for characterization and quantification of histone post-translational modifications. Karch KR, Zee BM, Garcia BA Journal of proteome research 25325711 J Proteome Res 2014 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/25325711
Post-Translational Modification Profiling--a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Merbl Y, Kirschner MW Current protocols in protein science 25081743 Curr Protoc Protein Sci 2014 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/25081743
A proteomic glimpse into the initial global epigenetic changes during HIV infection. Britton LM, Sova P, Belisle S, Liu S, Chan EY, Katze MG, Garcia BA Proteomics 25116026 Proteomics 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25116026
SnapShot: histone modifications. Huang H, Sabari BR, Garcia BA, Allis CD, Zhao Y Cell 25303536 Cell 2014 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/25303536
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Gaspar-Maia A, Qadeer ZA, Hasson D, Ratnakumar K, Leu NA, Leroy G, Liu S, Costanzi C, Valle-Garcia D, Schaniel C, Lemischka I, Garcia B, Pehrson JR, Bernstein E Nature communications 23463008 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23463008
Origins and formation of histone methylation across the human cell cycle. Zee BM, Britton LM, Wolle D, Haberman DM, Garcia BA Molecular and cellular biology 22547680 Mol Cell Biol 2012 Jul https://www.ncbi.nlm.nih.gov/pubmed/22547680
Discovery of lysine post-translational modifications through mass spectrometric detection. Zee BM, Garcia BA Essays in biochemistry 22708569 Essays Biochem 2012 https://www.ncbi.nlm.nih.gov/pubmed/22708569
Validation of protein acetylation by mass spectrometry. Zee BM, Garcia BA Methods in molecular biology (Clifton, N.J.) 23381849 Methods Mol Biol 2013 https://www.ncbi.nlm.nih.gov/pubmed/23381849
Breaking the histone code with quantitative mass spectrometry. Britton LM, Gonzales-Cope M, Zee BM, Garcia BA Expert review of proteomics 21999833 Expert Rev Proteomics 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21999833
Proteomic interrogation of human chromatin. Torrente MP, Zee BM, Young NL, Baliban RC, LeRoy G, Floudas CA, Hake SB, Garcia BA PloS one 21935452 PLoS One 2011 https://www.ncbi.nlm.nih.gov/pubmed/21935452
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Kang S, Tsai LT, Zhou Y, Evertts A, Xu S, Griffin MJ, Issner R, Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, Rosen ED Nature cell biology 25503565 Nat Cell Biol 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25503565
Drawbacks in the use of unconventional hydrophobic anhydrides for histone derivatization in bottom-up proteomics PTM analysis. Sidoli S, Yuan ZF, Lin S, Karch K, Wang X, Bhanu N, Arnaudo AM, Britton LM, Cao XJ, Gonzales-Cope M, Han Y, Liu S, Molden RC, Wein S, Afjehi-Sadat L, Garcia BA Proteomics 25641854 Proteomics 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25641854
De novo peptide design and experimental validation of histone methyltransferase inhibitors. Smadbeck J, Peterson MB, Zee BM, Garapaty S, Mago A, Lee C, Giannis A, Trojer P, Garcia BA, Floudas CA PloS one 24587223 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24587223
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen LH, Curtis C, Emtage S, Fan L, Gheyi T, Li F, Liu S, Martin JR, Mendel D, Olsen JB, Pelletier L, Shatseva T, Wu S, Zhang FF, Arrowsmith CH, Brown PJ, Campbell RM, Garcia BA, Barsyte-Lovejoy D, Mader M, Vedadi M The Journal of biological chemistry 25825497 J Biol Chem 2015 May 29 https://www.ncbi.nlm.nih.gov/pubmed/25825497
Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications. Vasudevan D, Hickok JR, Bovee RC, Pham V, Mantell LL, Bahroos N, Kanabar P, Cao XJ, Maienschein-Cline M, Garcia BA, Thomas DD Cancer research 26542213 Cancer Res 2015 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/26542213
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Multiscale photoacoustic microscopy of single-walled carbon nanotube-incorporated tissue engineering scaffolds. Cai X, Paratala BS, Hu S, Sitharaman B, Wang LV Tissue engineering. Part C, Methods 22082018 Tissue Eng Part C Methods 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22082018
Physicochemical characterization, and relaxometry studies of micro-graphite oxide, graphene nanoplatelets, and nanoribbons. Paratala BS, Jacobson BD, Kanakia S, Francis LD, Sitharaman B PloS one 22685555 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22685555
In vitro cytocompatibility of one-dimensional and two-dimensional nanostructure-reinforced biodegradable polymeric nanocomposites. Farshid B, Lalwani G, Sitharaman B Journal of biomedical materials research. Part A 25367032 J Biomed Mater Res A 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25367032
Tungsten disulfide nanotubes reinforced biodegradable polymers for bone tissue engineering. Lalwani G, Henslee AM, Farshid B, Parmar P, Lin L, Qin YX, Kasper FK, Mikos AG, Sitharaman B Acta biomaterialia 23727293 Acta Biomater 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23727293
Fabrication and cytocompatibility of in situ crosslinked carbon nanomaterial films. Patel SC, Lalwani G, Grover K, Qin YX, Sitharaman B Scientific reports 26018775 Sci Rep 2015 May 28 https://www.ncbi.nlm.nih.gov/pubmed/26018775
Interaction of graphene nanoribbons with components of the blood vascular system. Chowdhury SM, Fang J, Sitharaman B Future science OA 26925250 Future Sci OA 2015 https://www.ncbi.nlm.nih.gov/pubmed/26925250
The magnetic, relaxometric, and optical properties of gadolinium-catalyzed single walled carbon nanotubes. Sitharaman B, Jacobson BD, Wadghiri YZ, Bryant H, Frank J Journal of applied physics 23653487 J Appl Phys 2013 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/23653487
Cytotoxicity, cytocompatibility, cell-labeling efficiency, and in vitro cellular magnetic resonance imaging of gadolinium-catalyzed single-walled carbon nanotubes. Avti PK, Caparelli ED, Sitharaman B Journal of biomedical materials research. Part A 23686792 J Biomed Mater Res A 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23686792
Detection, mapping, and quantification of single walled carbon nanotubes in histological specimens with photoacoustic microscopy. Avti PK, Hu S, Favazza C, Mikos AG, Jansen JA, Shroyer KR, Wang LV, Sitharaman B PloS one 22496892 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22496892
Graphene-based contrast agents for photoacoustic and thermoacoustic tomography. Lalwani G, Cai X, Nie L, Wang LV, Sitharaman B Photoacoustics 24490141 Photoacoustics 2013 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/24490141
Multimodal ultrasound-photoacoustic imaging of tissue engineering scaffolds and blood oxygen saturation in and around the scaffolds. Talukdar Y, Avti P, Sun J, Sitharaman B Tissue engineering. Part C, Methods 24107069 Tissue Eng Part C Methods 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24107069
A novel nanoparticle-enhanced photoacoustic stimulus for bone tissue engineering. Sitharaman B, Avti PK, Schaefer K, Talukdar Y, Longtin JP Tissue engineering. Part A 21395444 Tissue Eng Part A 2011 Jul https://www.ncbi.nlm.nih.gov/pubmed/21395444
Synthesis, Characterization, In Vitro Phantom Imaging, and Cytotoxicity of A Novel Graphene-Based Multimodal Magnetic Resonance Imaging - X-Ray Computed Tomography Contrast Agent. Lalwani G, Sundararaj JL, Schaefer K, Button T, Sitharaman B Journal of materials chemistry. B 24999431 J Mater Chem B 2014 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/24999431
Boron nitride nanotubes and nanoplatelets as reinforcing agents of polymeric matrices for bone tissue engineering. Farshid B, Lalwani G, Shir Mohammadi M, Simonsen J, Sitharaman B Journal of biomedical materials research. Part B, Applied biomaterials 26526153 J Biomed Mater Res B Appl Biomater 2017 Feb https://www.ncbi.nlm.nih.gov/pubmed/26526153
Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells. Rashkow JT, Talukdar Y, Lalwani G, Sitharaman B Nanomedicine (London, England) 26080694 Nanomedicine (Lond) 2015 https://www.ncbi.nlm.nih.gov/pubmed/26080694
Three-dimensional carbon nanotube scaffolds for long-term maintenance and expansion of human mesenchymal stem cells. Lalwani G, D'agati M, Gopalan A, Patel SC, Talukdar Y, Sitharaman B Journal of biomedical materials research. Part A 28295953 J Biomed Mater Res A 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28295953
Graphene-based platforms for cancer therapeutics. Patel SC, Lee S, Lalwani G, Suhrland C, Chowdhury SM, Sitharaman B Therapeutic delivery 26769305 Ther Deliv 2016 https://www.ncbi.nlm.nih.gov/pubmed/26769305
Cell specific cytotoxicity and uptake of graphene nanoribbons. Mullick Chowdhury S, Lalwani G, Zhang K, Yang JY, Neville K, Sitharaman B Biomaterials 23072942 Biomaterials 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23072942
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Vasoactive effects of stable aqueous suspensions of single walled carbon nanotubes in hamsters and mice. Frame MD, Dewar AM, Mullick Chowdhury S, Sitharaman B Nanotoxicology 23992463 Nanotoxicology 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/23992463
Toward single-walled carbon nanotube-gadolinium complex as advanced MRI contrast agents: pharmacodynamics and global genomic response in small animals. Avti PK, Talukdar Y, Sirotkin MV, Shroyer KR, Sitharaman B Journal of biomedical materials research. Part B, Applied biomaterials 23559429 J Biomed Mater Res B Appl Biomater 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23559429
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Delivery of long chain C(16) and C(24) ceramide in HeLa cells using oxidized graphene nanoribbons. Suhrland C, Truman JP, Obeid LM, Sitharaman B Journal of biomedical materials research. Part B, Applied biomaterials 31444959 J Biomed Mater Res B Appl Biomater 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/31444959
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In Vitro Bioactivity of One- and Two-Dimensional Nanoparticle-Incorporated Bone Tissue Engineering Scaffolds. Rashkow JT, Lalwani G, Sitharaman B Tissue engineering. Part A 28762866 Tissue Eng Part A 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/28762866
Quantification of single-cell nanoparticle concentrations and the distribution of these concentrations in cell population. Rashkow JT, Patel SC, Tappero R, Sitharaman B Journal of the Royal Society, Interface 24554576 J R Soc Interface 2014 May 6 https://www.ncbi.nlm.nih.gov/pubmed/24554576
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Toxicology of graphene-based nanomaterials. Lalwani G, D'Agati M, Khan AM, Sitharaman B Advanced drug delivery reviews 27154267 Adv Drug Deliv Rev 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27154267
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Enzymatic Degradation of Oxidized and Reduced Graphene Nanoribbons by Lignin Peroxidase. Lalwani G, Xing W, Sitharaman B Journal of materials chemistry. B 25215188 J Mater Chem B 2014 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/25215188
Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Chowdhury SM, Surhland C, Sanchez Z, Chaudhary P, Suresh Kumar MA, Lee S, Peña LA, Waring M, Sitharaman B, Naidu M Nanomedicine : nanotechnology, biology, and medicine 25131339 Nanomedicine 2015 Jan https://www.ncbi.nlm.nih.gov/pubmed/25131339
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In vivo imaging of transplanted stem cells in the central nervous system. Duffy BA, Weitz AJ, Lee JH Current opinion in genetics & development 25461455 Curr Opin Genet Dev 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25461455
Tracing activity across the whole brain neural network with optogenetic functional magnetic resonance imaging. Lee JH Frontiers in neuroinformatics 22046160 Front Neuroinform 2011 https://www.ncbi.nlm.nih.gov/pubmed/22046160
MRI compatible optrodes for simultaneous LFP and optogenetic fMRI investigation of seizure-like afterdischarges. Duffy BA, Choy M, Chuapoco MR, Madsen M, Lee JH NeuroImage 26208873 Neuroimage 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26208873
High spatial resolution compressed sensing (HSPARSE) functional MRI. Fang Z, Van Le N, Choy M, Lee JH Magnetic resonance in medicine 26511101 Magn Reson Med 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/26511101
Silicon coupled with plasmon nanocavity generates bright visible hot-luminescence. Cho CH, Aspetti CO, Park J, Agarwal R Nature photonics 23710256 Nat Photonics 2013 https://www.ncbi.nlm.nih.gov/pubmed/23710256
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Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles. Cely I, Yiv S, Yin Q, Shahidzadeh A, Tang L, Cheng J, Uckun FM Journal of analytical oncology 23730399 J Anal Oncol 2012 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/23730399
PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation. Zhang Y, Yin Q, Lu H, Xia H, Lin Y, Cheng J ACS macro letters 24159425 ACS Macro Lett 2013 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/24159425
Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation. Yin L, Song Z, Qu Q, Kim KH, Zheng N, Yao C, Chaudhury I, Tang H, Gabrielson NP, Uckun FM, Cheng J Angewandte Chemie (International ed. in English) 23610013 Angew Chem Int Ed Engl 2013 May 27 https://www.ncbi.nlm.nih.gov/pubmed/23610013
Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates. Tang L, Gabrielson NP, Uckun FM, Fan TM, Cheng J Molecular pharmaceutics 23301497 Mol Pharm 2013 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/23301497
Polypeptides with quaternary phosphonium side chains: synthesis, characterization, and cell-penetrating properties. Song Z, Zheng N, Ba X, Yin L, Zhang R, Ma L, Cheng J Biomacromolecules 24635536 Biomacromolecules 2014 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/24635536
Reconfiguring the architectures of cationic helical polypeptides to control non-viral gene delivery. Yin L, Song Z, Kim KH, Zheng N, Tang H, Lu H, Gabrielson N, Cheng J Biomaterials 23283350 Biomaterials 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23283350
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Helical Poly(arginine) Mimics with Superior Cell-Penetrating and Molecular Transporting Properties. Tang H, Yin L, Kim KH, Cheng J Chemical science 25400902 Chem Sci 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/25400902
A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies. Uckun FM, Qazi S, Ma H, Yin L, Cheng J EBioMedicine 25599086 EBioMedicine 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25599086
Selective in vivo metabolic cell-labeling-mediated cancer targeting. Wang H, Wang R, Cai K, He H, Liu Y, Yen J, Wang Z, Xu M, Sun Y, Zhou X, Yin Q, Tang L, Dobrucki IT, Dobrucki LW, Chaney EJ, Boppart SA, Fan TM, Lezmi S, Chen X, Yin L, Cheng J Nature chemical biology 28192414 Nat Chem Biol 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/28192414
Manipulating the membrane penetration mechanism of helical polypeptides via aromatic modification for efficient gene delivery. Zheng N, Song Z, Yang J, Liu Y, Li F, Cheng J, Yin L Acta biomaterialia 28476586 Acta Biomater 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28476586
Targeting tumor vasculature with aptamer-functionalized doxorubicin-polylactide nanoconjugates for enhanced cancer therapy. Tang L, Tong R, Coyle VJ, Yin Q, Pondenis H, Borst LB, Cheng J, Fan TM ACS nano 25938427 ACS Nano 2015 May 26 https://www.ncbi.nlm.nih.gov/pubmed/25938427
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Dynamics and Molecular Mechanisms of p53 Transcriptional Activation. Offutt TL, Ieong PU, Demir Ö, Amaro RE Biochemistry 30388364 Biochemistry 2018 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/30388364
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Expression of essential B cell development genes in horses with common variable immunodeficiency. Tallmadge RL, Such KA, Miller KC, Matychak MB, Felippe MJ Molecular immunology 22464097 Mol Immunol 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22464097
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Effects of autologous stromal cells and cytokines on differentiation of equine bone marrow-derived progenitor cells. Schwab UE, Tallmadge RL, Matychak MB, Felippe MJB American journal of veterinary research 28945121 Am J Vet Res 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28945121
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Three-dimensional continuous particle focusing in a microfluidic channel via standing surface acoustic waves (SSAW). Shi J, Yazdi S, Lin SC, Ding X, Chiang IK, Sharp K, Huang TJ Lab on a chip 21709881 Lab Chip 2011 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/21709881
A reconfigurable plasmofluidic lens. Zhao C, Liu Y, Zhao Y, Fang N, Huang TJ Nature communications 23929463 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23929463
Microfluidic opportunities in the field of nutrition. Li S, Kiehne J, Sinoway LI, Cameron CE, Huang TJ Lab on a chip 24056522 Lab Chip 2013 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/24056522
Accelerating drug discovery via organs-on-chips. Chan CY, Huang PH, Guo F, Ding X, Kapur V, Mai JD, Yuen PK, Huang TJ Lab on a chip 24193241 Lab Chip 2013 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/24193241
Immunological analyses of whole blood via "microfluidic drifting" based flow cytometric chip. Nawaz AA, Nissly RH, Li P, Chen Y, Guo F, Li S, Shariff YM, Qureshi AN, Wang L, Huang TJ Annals of biomedical engineering 24893596 Ann Biomed Eng 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/24893596
Theory and experiment on particle trapping and manipulation via optothermally generated bubbles. Zhao C, Xie Y, Mao Z, Zhao Y, Rufo J, Yang S, Guo F, Mai JD, Huang TJ Lab on a chip 24276624 Lab Chip 2014 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/24276624
Dark-field illumination on zero-mode waveguide/microfluidic hybrid chip reveals T4 replisomal protein interactions. Zhao Y, Chen D, Yue H, Spiering MM, Zhao C, Benkovic SJ, Huang TJ Nano letters 24628474 Nano Lett 2014 https://www.ncbi.nlm.nih.gov/pubmed/24628474
Continuous enrichment of low-abundance cell samples using standing surface acoustic waves (SSAW). Chen Y, Li S, Gu Y, Li P, Ding X, Wang L, McCoy JP, Levine SJ, Huang TJ Lab on a chip 24413889 Lab Chip 2014 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/24413889
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves. Ding X, Lin SC, Kiraly B, Yue H, Li S, Chiang IK, Shi J, Benkovic SJ, Huang TJ Proceedings of the National Academy of Sciences of the United States of America 22733731 Proc Natl Acad Sci U S A 2012 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/22733731
Fabrication and characterization of beaded SiC quantum rings with anomalous red spectral shift. Yang S, Kiraly B, Wang WY, Shang S, Cao B, Zeng H, Zhao Y, Li W, Liu ZK, Cai W, Huang TJ Advanced materials (Deerfield Beach, Fla.) 22911493 Adv Mater 2012 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/22911493
A single-layer, planar, optofluidic switch powered by acoustically driven, oscillating microbubbles. Huang PH, Ian Lapsley M, Ahmed D, Chen Y, Wang L, Jun Huang T Applied physics letters 23112348 Appl Phys Lett 2012 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/23112348
Optofluidic tunable microlens by manipulating the liquid meniscus using a flared microfluidic structure. Mao X, Stratton ZI, Nawaz AA, Lin SC, Huang TJ Biomicrofluidics 21267439 Biomicrofluidics 2010 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/21267439
Optoacoustic tweezers: a programmable, localized cell concentrator based on opto-thermally generated, acoustically activated, surface bubbles. Xie Y, Zhao C, Zhao Y, Li S, Rufo J, Yang S, Guo F, Huang TJ Lab on a chip 23511348 Lab Chip 2013 May 7 https://www.ncbi.nlm.nih.gov/pubmed/23511348
Tunable nanowire patterning using standing surface acoustic waves. Chen Y, Ding X, Steven Lin SC, Yang S, Huang PH, Nama N, Zhao Y, Nawaz AA, Guo F, Wang W, Gu Y, Mallouk TE, Huang TJ ACS nano 23540330 ACS Nano 2013 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/23540330
Label-free measurements of reaction kinetics using a droplet-based optofluidic device. Mao Z, Guo F, Xie Y, Zhao Y, Lapsley MI, Wang L, Mai JD, Costanzo F, Huang TJ Journal of laboratory automation 25249275 J Lab Autom 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25249275
Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves. Guo F, Zhou W, Li P, Mao Z, Yennawar NH, French JB, Huang TJ Small (Weinheim an der Bergstrasse, Germany) 25641793 Small 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25641793
Combining the Masking and Scaffolding Modalities of Colloidal Crystal Templates: Plasmonic Nanoparticle Arrays with Multiple Periodicities. Yang S, Slotcavage D, Mai JD, Liang W, Xie Y, Chen Y, Huang TJ Chemistry of materials : a publication of the American Chemical Society 25620849 Chem Mater 2014 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/25620849
In situ fabrication of 3D Ag@ZnO nanostructures for microfluidic surface-enhanced Raman scattering systems. Xie Y, Yang S, Mao Z, Li P, Zhao C, Cohick Z, Huang PH, Huang TJ ACS nano 25402207 ACS Nano 2014 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/25402207
Cell separation using tilted-angle standing surface acoustic waves. Ding X, Peng Z, Lin SC, Geri M, Li S, Li P, Chen Y, Dao M, Suresh S, Huang TJ Proceedings of the National Academy of Sciences of the United States of America 25157150 Proc Natl Acad Sci U S A 2014 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/25157150
A reliable and programmable acoustofluidic pump powered by oscillating sharp-edge structures. Huang PH, Nama N, Mao Z, Li P, Rufo J, Chen Y, Xie Y, Wei CH, Wang L, Huang TJ Lab on a chip 25188786 Lab Chip 2014 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/25188786
Lab-on-a-chip technologies for single-molecule studies. Zhao Y, Chen D, Yue H, French JB, Rufo J, Benkovic SJ, Huang TJ Lab on a chip 23670195 Lab Chip 2013 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/23670195
Unconventional microfluidics: expanding the discipline. Nawaz AA, Mao X, Stratton ZS, Huang TJ Lab on a chip 23478651 Lab Chip 2013 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/23478651
Three-dimensional hydrodynamic focusing method for polyplex synthesis. Lu M, Ho YP, Grigsby CL, Nawaz AA, Leong KW, Huang TJ ACS nano 24341632 ACS Nano 2014 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/24341632
Probing cell-cell communication with microfluidic devices. Guo F, French JB, Li P, Zhao H, Chan CY, Fick JR, Benkovic SJ, Huang TJ Lab on a chip 23843092 Lab Chip 2013 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/23843092
An acoustofluidic micromixer based on oscillating sidewall sharp-edges. Huang PH, Xie Y, Ahmed D, Rufo J, Nama N, Chen Y, Chan CY, Huang TJ Lab on a chip 23896797 Lab Chip 2013 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/23896797
Standing surface acoustic wave (SSAW) based multichannel cell sorting. Ding X, Lin SC, Lapsley MI, Li S, Guo X, Chan CY, Chiang IK, Wang L, McCoy JP, Huang TJ Lab on a chip 22992833 Lab Chip 2012 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/22992833
Microfluidic synthesis of multifunctional Janus particles for biomedical applications. Yang S, Guo F, Kiraly B, Mao X, Lu M, Leong KW, Huang TJ Lab on a chip 22584998 Lab Chip 2012 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/22584998
Revisiting lab-on-a-chip technology for drug discovery. Neuži P, Giselbrecht S, Länge K, Huang TJ, Manz A Nature reviews. Drug discovery 22850786 Nat Rev Drug Discov 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22850786
Optofluidic imaging: now and beyond. Zhao Y, Stratton ZS, Guo F, Lapsley MI, Chan CY, Lin SC, Huang TJ Lab on a chip 23138193 Lab Chip 2013 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/23138193
A droplet-based, optofluidic device for high-throughput, quantitative bioanalysis. Guo F, Lapsley MI, Nawaz AA, Zhao Y, Lin SC, Chen Y, Yang S, Zhao XZ, Huang TJ Analytical chemistry 23140515 Anal Chem 2012 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/23140515
An on-chip, multichannel droplet sorter using standing surface acoustic waves. Li S, Ding X, Guo F, Chen Y, Lapsley MI, Lin SC, Wang L, McCoy JP, Cameron CE, Huang TJ Analytical chemistry 23647057 Anal Chem 2013 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/23647057
Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles. Ahmed D, Chan CY, Lin SC, Muddana HS, Nama N, Benkovic SJ, Huang TJ Lab on a chip 23254861 Lab Chip 2013 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/23254861
Probing circulating tumor cells in microfluidics. Li P, Stratton ZS, Dao M, Ritz J, Huang TJ Lab on a chip 23306378 Lab Chip 2013 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/23306378
Investigation of acoustic streaming patterns around oscillating sharp edges. Nama N, Huang PH, Huang TJ, Costanzo F Lab on a chip 24903475 Lab Chip 2014 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/24903475
All-Optical Modulation of Localized Surface Plasmon Coupling in a Hybrid System Composed of Photo-Switchable Gratings and Au Nanodisk Arrays. Liu YJ, Zheng YB, Liou J, Chiang IK, Khoo IC, Huang TJ The journal of physical chemistry. C, Nanomaterials and interfaces 21643480 J Phys Chem C Nanomater Interfaces 2011 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/21643480
A single-layer, planar, optofluidic Mach-Zehnder interferometer for label-free detection. Lapsley MI, Chiang IK, Zheng YB, Ding X, Mao X, Huang TJ Lab on a chip 21479332 Lab Chip 2011 May 21 https://www.ncbi.nlm.nih.gov/pubmed/21479332
Tunable patterning of microparticles and cells using standing surface acoustic waves. Ding X, Shi J, Lin SC, Yazdi S, Kiraly B, Huang TJ Lab on a chip 22648600 Lab Chip 2012 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/22648600
Surface acoustic wave (SAW) acoustophoresis: now and beyond. Lin SC, Mao X, Huang TJ Lab on a chip 22781941 Lab Chip 2012 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/22781941
Microfluidic diagnostics for the developing world. Mao X, Huang TJ Lab on a chip 22406768 Lab Chip 2012 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/22406768
Single-shot characterization of enzymatic reaction constants Km and kcat by an acoustic-driven, bubble-based fast micromixer. Xie Y, Ahmed D, Lapsley MI, Lin SC, Nawaz AA, Wang L, Huang TJ Analytical chemistry 22880882 Anal Chem 2012 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/22880882
Exploiting mechanical biomarkers in microfluidics. Mao X, Huang TJ Lab on a chip 22968689 Lab Chip 2012 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/22968689
Molecular plasmonics for biology and nanomedicine. Zheng YB, Kiraly B, Weiss PS, Huang TJ Nanomedicine (London, England) 22630155 Nanomedicine (Lond) 2012 May https://www.ncbi.nlm.nih.gov/pubmed/22630155
Selectively manipulable acoustic-powered microswimmers. Ahmed D, Lu M, Nourhani A, Lammert PE, Stratton Z, Muddana HS, Crespi VH, Huang TJ Scientific reports 25993314 Sci Rep 2015 May 20 https://www.ncbi.nlm.nih.gov/pubmed/25993314
Standing surface acoustic wave (SSAW)-based cell washing. Li S, Ding X, Mao Z, Chen Y, Nama N, Guo F, Li P, Wang L, Cameron CE, Huang TJ Lab on a chip 25372273 Lab Chip 2015 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/25372273
Acoustofluidic chemical waveform generator and switch. Ahmed D, Muddana HS, Lu M, French JB, Ozcelik A, Fang Y, Butler PJ, Benkovic SJ, Manz A, Huang TJ Analytical chemistry 25405550 Anal Chem 2014 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/25405550
Acoustic propulsion of nanorod motors inside living cells. Wang W, Li S, Mair L, Ahmed S, Huang TJ, Mallouk TE Angewandte Chemie (International ed. in English) 24677393 Angew Chem Int Ed Engl 2014 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/24677393
Controlling cell-cell interactions using surface acoustic waves. Guo F, Li P, French JB, Mao Z, Zhao H, Li S, Nama N, Fick JR, Benkovic SJ, Huang TJ Proceedings of the National Academy of Sciences of the United States of America 25535339 Proc Natl Acad Sci U S A 2015 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/25535339
Acoustic separation of circulating tumor cells. Li P, Mao Z, Peng Z, Zhou L, Chen Y, Huang PH, Truica CI, Drabick JJ, El-Deiry WS, Dao M, Suresh S, Huang TJ Proceedings of the National Academy of Sciences of the United States of America 25848039 Proc Natl Acad Sci U S A 2015 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/25848039
Standing surface acoustic wave (SSAW)-based microfluidic cytometer. Chen Y, Nawaz AA, Zhao Y, Huang PH, McCoy JP, Levine SJ, Wang L, Huang TJ Lab on a chip 24406848 Lab Chip 2014 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/24406848
Rare cell isolation and analysis in microfluidics. Chen Y, Li P, Huang PH, Xie Y, Mai JD, Wang L, Nguyen NT, Huang TJ Lab on a chip 24406985 Lab Chip 2014 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/24406985
Acoustofluidic relay: sequential trapping and transporting of microparticles via acoustically excited oscillating bubbles. Xie Y, Ahmed D, Lapsley MI, Lu M, Li S, Huang TJ Journal of laboratory automation 23592570 J Lab Autom 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/23592570
Holographically formed, acoustically switchable gratings based on polymer-dispersed liquid crystals. Liu YJ, Lu M, Ding X, Leong ES, Lin SC, Shi J, Teng JH, Wang L, Bunning TJ, Huang TJ Journal of laboratory automation 22909448 J Lab Autom 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/22909448
An integrated, multiparametric flow cytometry chip using "microfluidic drifting" based three-dimensional hydrodynamic focusing. Mao X, Nawaz AA, Lin SC, Lapsley MI, Zhao Y, McCoy JP, El-Deiry WS, Huang TJ Biomicrofluidics 22567082 Biomicrofluidics 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22567082
Scalable manufacturing of plasmonic nanodisk dimers and cusp nanostructures using salting-out quenching method and colloidal lithography. Juluri BK, Chaturvedi N, Hao Q, Lu M, Velegol D, Jensen L, Huang TJ ACS nano 21692473 ACS Nano 2011 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/21692473
An acoustofluidic micromixer via bubble inception and cavitation from microchannel sidewalls. Ozcelik A, Ahmed D, Xie Y, Nama N, Qu Z, Nawaz AA, Huang TJ Analytical chemistry 24754496 Anal Chem 2014 May 20 https://www.ncbi.nlm.nih.gov/pubmed/24754496
Superhydrophobic Surface Enhanced Raman Scattering Sensing using Janus Particle Arrays Realized by Site-Specific Electrochemical Growth. Yang S, Hricko PJ, Huang PH, Li S, Zhao Y, Xie Y, Guo F, Wang L, Huang TJ Journal of materials chemistry. C 24748991 J Mater Chem C Mater 2014 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/24748991
Shape-controlled synthesis of hybrid nanomaterials via three-dimensional hydrodynamic focusing. Lu M, Yang S, Ho YP, Grigsby CL, Leong KW, Huang TJ ACS nano 25268035 ACS Nano 2014 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/25268035
Multifunctional porous silicon nanopillar arrays: antireflection, superhydrophobicity, photoluminescence, and surface-enhanced Raman scattering. Kiraly B, Yang S, Huang TJ Nanotechnology 23703091 Nanotechnology 2013 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/23703091
Sub-micrometer-precision, three-dimensional (3D) hydrodynamic focusing via "microfluidic drifting". Nawaz AA, Zhang X, Mao X, Rufo J, Lin SC, Guo F, Zhao Y, Lapsley M, Li P, McCoy JP, Levine SJ, Huang TJ Lab on a chip 24287742 Lab Chip 2014 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/24287742
Surface acoustic wave microfluidics. Ding X, Li P, Lin SC, Stratton ZS, Nama N, Guo F, Slotcavage D, Mao X, Shi J, Costanzo F, Huang TJ Lab on a chip 23900527 Lab Chip 2013 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/23900527
Surface-Enhanced Raman Scattering Study on Graphene-Coated Metallic Nanostructure Substrates. Hao Q, Wang B, Bossard JA, Kiraly B, Zeng Y, Chiang IK, Jensen L, Werner DH, Huang TJ The journal of physical chemistry. C, Nanomaterials and interfaces 24772200 J Phys Chem C Nanomater Interfaces 2012 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/24772200
Standing surface acoustic wave based cell coculture. Li S, Guo F, Chen Y, Ding X, Li P, Wang L, Cameron CE, Huang TJ Analytical chemistry 25232648 Anal Chem 2014 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/25232648
Electrochemically Created Highly Surface Roughened Ag Nanoplate Arrays for SERS Biosensing Applications. Yang S, Slotcavage D, Mai JD, Guo F, Li S, Zhao Y, Lei Y, Cameron CE, Huang TJ Journal of materials chemistry. C 25383191 J Mater Chem C Mater 2014 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/25383191
High-speed optical humidity sensors based on chiral sculptured thin films. Liu YJ, Shi J, Zhang F, Liang H, Xu J, Lakhtakia A, Fonash SJ, Huang TJ Sensors and actuators. B, Chemical 30739999 Sens Actuators B Chem 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/30739999
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Identification of regulatory targets for the bacterial Nus factor complex. Baniulyte G, Singh N, Benoit C, Johnson R, Ferguson R, Paramo M, Stringer AM, Scott A, Lapierre P, Wade JT Nature communications 29229908 Nat Commun 2017 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/29229908
The BvgAS Regulon of Bordetella pertussis. Moon K, Bonocora RP, Kim DD, Chen Q, Wade JT, Stibitz S, Hinton DM mBio 29018122 mBio 2017 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/29018122
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Identification of novel sRNAs in mycobacterial species. Tsai CH, Baranowski C, Livny J, McDonough KA, Wade JT, Contreras LM PloS one 24244498 PLoS One 2013 https://www.ncbi.nlm.nih.gov/pubmed/24244498
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Genome-Scale Mapping of Escherichia coli σ54 Reveals Widespread, Conserved Intragenic Binding. Bonocora RP, Smith C, Lapierre P, Wade JT PLoS genetics 26425847 PLoS Genet 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26425847
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Identification of HilD-regulated genes in Salmonella enterica serovar Typhimurium. Petrone BL, Stringer AM, Wade JT Journal of bacteriology 24375101 J Bacteriol 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24375101
MrpJ Directly Regulates Proteus mirabilis Virulence Factors, Including Fimbriae and Type VI Secretion, during Urinary Tract Infection. Debnath I, Stringer AM, Smith SN, Bae E, Mobley HLT, Wade JT, Pearson MM Infection and immunity 30082479 Infect Immun 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30082479
FRUIT, a scar-free system for targeted chromosomal mutagenesis, epitope tagging, and promoter replacement in Escherichia coli and Salmonella enterica. Stringer AM, Singh N, Yermakova A, Petrone BL, Amarasinghe JJ, Reyes-Diaz L, Mantis NJ, Wade JT PloS one 23028641 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/23028641
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Determining the Specificity of Cascade Binding, Interference, and Primed Adaptation In Vivo in the Escherichia coli Type I-E CRISPR-Cas System. Cooper LA, Stringer AM, Wade JT mBio 29666291 mBio 2018 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/29666291
Chemical Inhibition of Kynureninase Reduces Pseudomonas aeruginosa Quorum Sensing and Virulence Factor Expression. Kasper SH, Bonocora RP, Wade JT, Musah RA, Cady NC ACS chemical biology 26785289 ACS Chem Biol 2016 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/26785289
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Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading. Lu Y, Gao J, Zhang DD, Gau V, Liao JC, Wong PK Analytical chemistry 23445209 Anal Chem 2013 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/23445209
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A UAV-Mounted Whole Cell Biosensor System for Environmental Monitoring Applications. Lu Y, Macias D, Dean ZS, Kreger NR, Wong PK IEEE transactions on nanobioscience 26584498 IEEE Trans Nanobioscience 2015 Dec https://www.ncbi.nlm.nih.gov/pubmed/26584498
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Molecular detection of bacterial pathogens using microparticle enhanced double-stranded DNA probes. Riahi R, Mach KE, Mohan R, Liao JC, Wong PK Analytical chemistry 21718053 Anal Chem 2011 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/21718053
Oncogenic KRAS confers chemoresistance by upregulating NRF2. Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD Cancer research 25339352 Cancer Res 2014 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/25339352
Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1. Chu M, Novak SM, Cover C, Wang AA, Chinyere IR, Juneman EB, Zarnescu DC, Wong PK, Gregorio CC Circulation 29101288 Circulation 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29101288
A Microfiltration Device for Urogenital Schistosomiasis Diagnostics. Xiao Y, Lu Y, Hsieh M, Liao J, Wong PK PloS one 27124499 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27124499
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Single cell nanobiosensors for dynamic gene expression profiling in native tissue microenvironments. Wang S, Riahi R, Li N, Zhang DD, Wong PK Advanced materials (Deerfield Beach, Fla.) 26314800 Adv Mater 2015 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/26314800
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC Proceedings of the National Academy of Sciences of the United States of America 26487682 Proc Natl Acad Sci U S A 2015 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/26487682
A microfluidic model for organ-specific extravasation of circulating tumor cells. Riahi R, Yang YL, Kim H, Jiang L, Wong PK, Zohar Y Biomicrofluidics 24803959 Biomicrofluidics 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24803959
Intelligent Systems and Technology for Integrative and Predictive Medicine: An ACP Approach. Wang FY, Wong PK ACM transactions on intelligent systems and technology 24883228 ACM Trans Intell Syst Technol 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24883228
Mechanically induced intercellular calcium communication in confined endothelial structures. Junkin M, Lu Y, Long J, Deymier PA, Hoying JB, Wong PK Biomaterials 23267827 Biomaterials 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23267827
Versatile control of Plasmodium falciparum gene expression with an inducible protein-RNA interaction. Goldfless SJ, Wagner JC, Niles JC Nature communications 25370483 Nat Commun 2014 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/25370483
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Least median of squares filtering of locally optimal point matches for compressible flow image registration. Castillo E, Castillo R, White B, Rojo J, Guerrero T Physics in medicine and biology 22797602 Phys Med Biol 2012 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/22797602
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Morphometry-based measurements of the structural response to whole-brain radiation. Fuentes D, Contreras J, Yu J, He R, Castillo E, Castillo R, Guerrero T International journal of computer assisted radiology and surgery 25408306 Int J Comput Assist Radiol Surg 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25408306
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Pre-Radiation Therapy Fluorine 18 Fluorodeoxyglucose PET Helps Identify Patients with Esophageal Cancer at High Risk for Radiation Pneumonitis. Castillo R, Pham N, Castillo E, Aso-Gonzalez S, Ansari S, Hobbs B, Palacio D, Skinner H, Guerrero TM Radiology 25584706 Radiology 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25584706
A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive. Castillo R, Castillo E, Fuentes D, Ahmad M, Wood AM, Ludwig MS, Guerrero T Physics in medicine and biology 23571679 Phys Med Biol 2013 May 7 https://www.ncbi.nlm.nih.gov/pubmed/23571679
Modeling lung deformation: a combined deformable image registration method with spatially varying Young's modulus estimates. Li M, Castillo E, Zheng XL, Luo HY, Castillo R, Wu Y, Guerrero T Medical physics 23927316 Med Phys 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23927316
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Comparison of 4-dimensional computed tomography ventilation with nuclear medicine ventilation-perfusion imaging: a clinical validation study. Vinogradskiy Y, Koo PJ, Castillo R, Castillo E, Guerrero T, Gaspar LE, Miften M, Kavanagh BD International journal of radiation oncology, biology, physics 24725702 Int J Radiat Oncol Biol Phys 2014 May 1 https://www.ncbi.nlm.nih.gov/pubmed/24725702
Results of a Multi-Institutional Phase 2 Clinical Trial for 4DCT-Ventilation Functional Avoidance Thoracic Radiation Therapy. Vinogradskiy Y, Castillo R, Castillo E, Schubert L, Jones BL, Faught A, Gaspar LE, Kwak J, Bowles DW, Waxweiler T, Dougherty JM, Gao D, Stevens C, Miften M, Kavanagh B, Grills I, Rusthoven CG, Guerrero T International journal of radiation oncology, biology, physics 34767934 Int J Radiat Oncol Biol Phys 2022 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/34767934
Cervical and Tumor-Associated Microbiomes in Botswana Women With and Without HIV With Carcinoma of the Cervix Before and After Definitive Chemoradiation. Sims TT, Yoshida-Court K, El Alam MB, Ramatlho P, Ketlametswe R, Ning MS, Robertson ES, Schmeler KM, Colbert LE, Klopp AH, Grover S JCO global oncology 41160784 JCO Glob Oncol 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/41160784
Computing global minimizers to a constrained B-spline image registration problem from optimal l1 perturbations to block match data. Castillo E, Castillo R, Fuentes D, Guerrero T Medical physics 24694135 Med Phys 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24694135
Pre-radiotherapy FDG PET predicts radiation pneumonitis in lung cancer. Castillo R, Pham N, Ansari S, Meshkov D, Castillo S, Li M, Olanrewaju A, Hobbs B, Castillo E, Guerrero T Radiation oncology (London, England) 24625207 Radiat Oncol 2014 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/24625207
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Quality assurance assessment of diagnostic and radiation therapy-simulation CT image registration for head and neck radiation therapy: anatomic region of interest-based comparison of rigid and deformable algorithms. Mohamed AS, Ruangskul MN, Awan MJ, Baron CA, Kalpathy-Cramer J, Castillo R, Castillo E, Guerrero TM, Kocak-Uzel E, Yang J, Court LE, Kantor ME, Gunn GB, Colen RR, Frank SJ, Garden AS, Rosenthal DI, Fuller CD Radiology 25380454 Radiology 2015 Mar https://www.ncbi.nlm.nih.gov/pubmed/25380454
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An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation. Potts MB, Lim DA Cell stem cell 22770236 Cell Stem Cell 2012 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/22770236
Distinct and separable roles for EZH2 in neurogenic astroglia. Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA eLife 24867641 Elife 2014 May 27 https://www.ncbi.nlm.nih.gov/pubmed/24867641
Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells. Delgado RN, Lim DA Developmental biology 26387477 Dev Biol 2015 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/26387477
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1. Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA Science (New York, N.Y.) 32241942 Science 2020 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/32241942
Normalization, bias correction, and peak calling for ChIP-seq. Diaz A, Park K, Lim DA, Song JS Statistical applications in genetics and molecular biology 22499706 Stat Appl Genet Mol Biol 2012 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/22499706
Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo. Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim DA Cell stem cell 23583100 Cell Stem Cell 2013 May 2 https://www.ncbi.nlm.nih.gov/pubmed/23583100
Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis. Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim DA Cell reports 25176653 Cell Rep 2014 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/25176653
Adult neural stem cells stake their ground. Lim DA, Alvarez-Buylla A Trends in neurosciences 25223700 Trends Neurosci 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/25223700
Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming. Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, Ramos AD, Hahn J, Margeta M, Oldham MC, Lim DA Neurosurgery 24887289 Neurosurgery 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24887289
Chromatin-based epigenetics of adult subventricular zone neural stem cells. Gonzales-Roybal G, Lim DA Frontiers in genetics 24115953 Front Genet 2013 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/24115953
Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA Stereotactic and functional neurosurgery 23343609 Stereotact Funct Neurosurg 2013 https://www.ncbi.nlm.nih.gov/pubmed/23343609
The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation. Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim DA The Journal of neuroscience : the official journal of the Society for Neuroscience 25209293 J Neurosci 2014 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/25209293
Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective. Han X, Brown E Optics express 20588906 Opt Express 2010 May 10 https://www.ncbi.nlm.nih.gov/pubmed/20588906
Multiphoton fluorescence recovery after photobleaching in bounded systems. Sullivan KD, Brown EB Physical review. E, Statistical, nonlinear, and soft matter physics 21728580 Phys Rev E Stat Nonlin Soft Matter Phys 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21728580
Two-photon and second harmonic microscopy in clinical and translational cancer research. Perry SW, Burke RM, Brown EB Annals of biomedical engineering 22258888 Ann Biomed Eng 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/22258888
In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice. Bouta EM, Wood RW, Brown EB, Rahimi H, Ritchlin CT, Schwarz EM The Journal of physiology 24421350 J Physiol 2014 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/24421350
Fluoxetine modulates breast cancer metastasis to the brain in a murine model. Shapovalov Y, Zettel M, Spielman SC, Amico-Ruvio SA, Kelly EA, Sipe GO, Dickerson IM, Majewska AK, Brown EB BMC cancer 25129445 BMC Cancer 2014 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/25129445
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The role of the lymphatic system in inflammatory-erosive arthritis. Bouta EM, Li J, Ju Y, Brown EB, Ritchlin CT, Xing L, Schwarz EM Seminars in cell & developmental biology 25598390 Semin Cell Dev Biol 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25598390
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Application of fiber-optic attenuated total reflection-FT-IR methods for in situ characterization of protein delivery systems in real time. McFearin CL, Sankaranarayanan J, Almutairi A Analytical chemistry 21476582 Anal Chem 2011 May 15 https://www.ncbi.nlm.nih.gov/pubmed/21476582
Photochemical mechanisms of light-triggered release from nanocarriers. Fomina N, Sankaranarayanan J, Almutairi A Advanced drug delivery reviews 22386560 Adv Drug Deliv Rev 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22386560
Nanogels from metal-chelating crosslinkers as versatile platforms applied to copper-64 PET imaging of tumors and metastases. Lux J, White AG, Chan M, Anderson CJ, Almutairi A Theranostics 25553115 Theranostics 2015 https://www.ncbi.nlm.nih.gov/pubmed/25553115
Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye. Huu VA, Luo J, Zhu J, Zhu J, Patel S, Boone A, Mahmoud E, McFearin C, Olejniczak J, de Gracia Lux C, Lux J, Fomina N, Huynh M, Zhang K, Almutairi A Journal of controlled release : official journal of the Controlled Release Society 25571784 J Control Release 2015 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/25571784
Collective activation of MRI agents via encapsulation and disease-triggered release. Viger ML, Sankaranarayanan J, de Gracia Lux C, Chan M, Almutairi A Journal of the American Chemical Society 23672342 J Am Chem Soc 2013 May 29 https://www.ncbi.nlm.nih.gov/pubmed/23672342
Highest Efficiency Two-Photon Degradable Copolymer for Remote Controlled Release. Olejniczak J, Sankaranarayanan J, Viger ML, Almutairi A ACS macro letters 24044102 ACS Macro Lett 2013 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/24044102
Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide. de Gracia Lux C, Joshi-Barr S, Nguyen T, Mahmoud E, Schopf E, Fomina N, Almutairi A Journal of the American Chemical Society 22946840 J Am Chem Soc 2012 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/22946840
A Single UV or Near IR Triggering Event Leads to Polymer Degradation into Small Molecules. de Gracia Lux C, McFearin CL, Joshi-Barr S, Sankaranarayanan J, Fomina N, Almutairi A ACS macro letters 23066523 ACS Macro Lett 2012 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/23066523
Nanogels as imaging agents for modalities spanning the electromagnetic spectrum. Chan M, Almutairi A Materials horizons 27398218 Mater Horiz 2016 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/27398218
Light-triggered chemical amplification to accelerate degradation and release from polymeric particles. Olejniczak J, Nguyen Huu VA, Lux J, Grossman M, He S, Almutairi A Chemical communications (Cambridge, England) 26445896 Chem Commun (Camb) 2015 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/26445896
Density gradient multilayer polymerization for creating complex tissue. Karpiak JV, Ner Y, Almutairi A Advanced materials (Deerfield Beach, Fla.) 22318771 Adv Mater 2012 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/22318771
Iron oxide nanoparticle-based magnetic resonance method to monitor release kinetics from polymeric particles with high resolution. Chan M, Schopf E, Sankaranarayanan J, Almutairi A Analytical chemistry 22891894 Anal Chem 2012 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/22891894
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Inflammation responsive logic gate nanoparticles for the delivery of proteins. Mahmoud EA, Sankaranarayanan J, Morachis JM, Kim G, Almutairi A Bioconjugate chemistry 21688843 Bioconjug Chem 2011 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/21688843
Tunable protein release from acetalated dextran microparticles: a platform for delivery of protein therapeutics to the heart post-MI. Suarez S, Grover GN, Braden RL, Christman KL, Almutairi A Biomacromolecules 24053580 Biomacromolecules 2013 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/24053580
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Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds. Fomina N, McFearin CL, Almutairi A Chemical communications (Cambridge, England) 22475792 Chem Commun (Camb) 2012 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/22475792
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Gold Nanoparticle-assisted Selective Photothermolysis of Adipose Tissue (NanoLipo). Sheng W, Alhasan AH, DiBernardo G, Almutairi KM, Rubin JP, DiBernardo BE, Almutairi A Plastic and reconstructive surgery. Global open 25587517 Plast Reconstr Surg Glob Open 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25587517
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Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent. Chan M, Lux J, Nishimura T, Akiyoshi K, Almutairi A Biomacromolecules 26278775 Biomacromolecules 2015 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/26278775
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Altered neuronal network and rescue in a human MECP2 duplication model. Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri AR Molecular psychiatry 26347316 Mol Psychiatry 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26347316
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Griesi-Oliveira K, Acab A, Gupta AR, Sunaga DY, Chailangkarn T, Nicol X, Nunez Y, Walker MF, Murdoch JD, Sanders SJ, Fernandez TV, Ji W, Lifton RP, Vadasz E, Dietrich A, Pradhan D, Song H, Ming GL, Gu X, Haddad G, Marchetto MC, Spitzer N, Passos-Bueno MR, State MW, Muotri AR Molecular psychiatry 25385366 Mol Psychiatry 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/25385366
The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. Acab A, Muotri AR Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 25851569 Neurotherapeutics 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25851569
Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony. Vessoni AT, Herai RH, Karpiak JV, Leal AM, Trujillo CA, Quinet A, Agnez Lima LF, Menck CF, Muotri AR Human molecular genetics 26755826 Hum Mol Genet 2016 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/26755826
Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons. Negraes PD, Cugola FR, Herai RH, Trujillo CA, Cristino AS, Chailangkarn T, Muotri AR, Duvvuri V Translational psychiatry 28291261 Transl Psychiatry 2017 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/28291261
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR Cell 21074045 Cell 2010 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/21074045
Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri AR, Gage FH, Chen G Stem cell research 23759711 Stem Cell Res 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23759711
KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G Proceedings of the National Academy of Sciences of the United States of America 26733678 Proc Natl Acad Sci U S A 2016 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/26733678
Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. Pillat MM, Lameu C, Trujillo CA, Glaser T, Cappellari AR, Negraes PD, Battastini AM, Schwindt TT, Muotri AR, Ulrich H Journal of cell science 27528403 J Cell Sci 2016 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/27528403
Systematic optimization of human pluripotent stem cells media using Design of Experiments. Marinho PA, Chailangkarn T, Muotri AR Scientific reports 25940691 Sci Rep 2015 May 5 https://www.ncbi.nlm.nih.gov/pubmed/25940691
Brains, genes, and primates. Izpisua Belmonte JC, Callaway EM, Caddick SJ, Churchland P, Feng G, Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S, Moutri AR, Movshon JA, Okano H, Reynolds JH, Ringach D, Sejnowski TJ, Silva AC, Strick PL, Wu J, Zhang F Neuron 25950631 Neuron 2015 May 6 https://www.ncbi.nlm.nih.gov/pubmed/25950631
Micro RNA detection in long-term fixed tissue of cortical glutamatergic pyramidal neurons after targeted laser-capture neuroanatomical microdissection. Herai RR, Stefanacci L, Hrvoj-Mihic B, Chailangkarn T, Hanson K, Semendeferi K, Muotri AR Journal of neuroscience methods 24992573 J Neurosci Methods 2014 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/24992573
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR Nature neuroscience 25108912 Nat Neurosci 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25108912
Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus. Lovatel GA, Elsner VR, Bertoldi K, Vanzella C, Moysés Fdos S, Vizuete A, Spindler C, Cechinel LR, Netto CA, Muotri AR, Siqueira IR Neurobiology of learning and memory 23357282 Neurobiol Learn Mem 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23357282
Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. Trujillo CA, Negraes PD, Schwindt TT, Lameu C, Carromeu C, Muotri AR, Pesquero JB, Cerqueira DM, Pillat MM, de Souza HD, Turaça LT, Abreu JG, Ulrich H The Journal of biological chemistry 23132855 J Biol Chem 2012 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/23132855
Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Hrvoj-Mihic B, Marchetto MC, Gage FH, Semendeferi K, Muotri AR Biological psychiatry 24041506 Biol Psychiatry 2014 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/24041506
Evolution, development, and plasticity of the human brain: from molecules to bones. Hrvoj-Mihic B, Bienvenu T, Stefanacci L, Muotri AR, Semendeferi K Frontiers in human neuroscience 24194709 Front Hum Neurosci 2013 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/24194709
Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri AR, Haddad GG Neuroscience 25559931 Neuroscience 2015 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/25559931
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH Proceedings of the National Academy of Sciences of the United States of America 22159035 Proc Natl Acad Sci U S A 2011 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/22159035
L1 Retrotransposition in Neural Progenitor Cells. Muotri AR Methods in molecular biology (Clifton, N.J.) 26895053 Methods Mol Biol 2016 https://www.ncbi.nlm.nih.gov/pubmed/26895053
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR Molecular psychiatry 27378147 Mol Psychiatry 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/27378147
Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. Thomas CA, Tejwani L, Trujillo CA, Negraes PD, Herai RH, Mesci P, Macia A, Crow YJ, Muotri AR Cell stem cell 28803918 Cell Stem Cell 2017 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/28803918
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH eLife 30730291 Elife 2019 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/30730291
Characterizing complex structural variation in germline and somatic genomes. Quinlan AR, Hall IM Trends in genetics : TIG 22094265 Trends Genet 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22094265
YAHA: fast and flexible long-read alignment with optimal breakpoint detection. Faust GG, Hall IM Bioinformatics (Oxford, England) 22829624 Bioinformatics 2012 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/22829624
Role of network-mediated stochasticity in mammalian drug resistance. Farquhar KS, Charlebois DA, Szenk M, Cohen J, Nevozhay D, Balázsi G Nature communications 31235692 Nat Commun 2019 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/31235692
Efflux Pump Control Alters Synthetic Gene Circuit Function. Diao J, Charlebois DA, Nevozhay D, Bódi Z, Pál C, Balázsi G ACS synthetic biology 27111147 ACS Synth Biol 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27111147
Two-dimensionality of yeast colony expansion accompanied by pattern formation. Chen L, Noorbakhsh J, Adams RM, Samaniego-Evans J, Agollah G, Nevozhay D, Kuzdzal-Fick J, Mehta P, Balázsi G PLoS computational biology 25504059 PLoS Comput Biol 2014 Dec https://www.ncbi.nlm.nih.gov/pubmed/25504059
The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response. Tiwari A, Balázsi G, Gennaro ML, Igoshin OA Physical biology 20733247 Phys Biol 2010 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/20733247
Tuning and controlling gene expression noise in synthetic gene networks. Murphy KF, Adams RM, Wang X, Balázsi G, Collins JJ Nucleic acids research 20211838 Nucleic Acids Res 2010 May https://www.ncbi.nlm.nih.gov/pubmed/20211838
Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli. Quan S, Ray JC, Kwota Z, Duong T, Balázsi G, Cooper TF, Monds RD PLoS genetics 22253602 PLoS Genet 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/22253602
Cellular Growth Arrest and Persistence from Enzyme Saturation. Ray JC, Wickersheim ML, Jalihal AP, Adeshina YO, Cooper TF, Balázsi G PLoS computational biology 27010473 PLoS Comput Biol 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27010473
Negative Regulation Gene Circuits for Efflux Pump Control. Charlebois DA, Diao J, Nevozhay D, Balázsi G Methods in molecular biology (Clifton, N.J.) 29754221 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29754221
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. Lee J, Lee J, Farquhar KS, Yun J, Frankenberger CA, Bevilacqua E, Yeung K, Kim EJ, Balázsi G, Rosner MR Proceedings of the National Academy of Sciences of the United States of America 24395801 Proc Natl Acad Sci U S A 2014 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/24395801
Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection. Rohde KH, Veiga DF, Caldwell S, Balázsi G, Russell DG PLoS pathogens 22737072 PLoS Pathog 2012 https://www.ncbi.nlm.nih.gov/pubmed/22737072
A common repressor pool results in indeterminacy of extrinsic noise. Stamatakis M, Adams RM, Balázsi G Chaos (Woodbury, N.Y.) 22225397 Chaos 2011 Dec https://www.ncbi.nlm.nih.gov/pubmed/22225397
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Network reconstruction reveals new links between aging and calorie restriction in yeast. Balázsi G HFSP journal 21119761 HFSP J 2010 Jun https://www.ncbi.nlm.nih.gov/pubmed/21119761
Stress-response balance drives the evolution of a network module and its host genome. González C, Ray JC, Manhart M, Adams RM, Nevozhay D, Morozov AV, Balázsi G Molecular systems biology 26324468 Mol Syst Biol 2015 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/26324468
Disadvantages and benefits of evolved unicellularity versus multicellularity in budding yeast. Kuzdzal-Fick JJ, Chen L, Balázsi G Ecology and evolution 31410258 Ecol Evol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31410258
MXD3 regulation of DAOY cell proliferation dictated by time course of activation. Ngo T, Barisone GA, Lam KS, Dίaz E BMC cell biology 25053245 BMC Cell Biol 2014 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/25053245
Role of MXD3 in proliferation of DAOY human medulloblastoma cells. Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E PloS one 22808009 PLoS One 2012 https://www.ncbi.nlm.nih.gov/pubmed/22808009
Mechanisms of excitatory synapse maturation by trans-synaptic organizing complexes. McMahon SA, Díaz E Current opinion in neurobiology 21242087 Curr Opin Neurobiol 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21242087
Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia. Satake N, Duong C, Chen C, Barisone GA, Diaz E, Tuscano J, Rocke DM, Nolta J, Nitin N British journal of haematology 25196579 Br J Haematol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25196579
Focus formation: a cell-based assay to determine the oncogenic potential of a gene. Alvarez A, Barisone GA, Diaz E Journal of visualized experiments : JoVE 25590282 J Vis Exp 2014 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/25590282
Activity-Dependent Palmitoylation Controls SynDIG1 Stability, Localization, and Function. Kaur I, Yarov-Yarovoy V, Kirk LM, Plambeck KE, Barragan EV, Ontiveros ES, Díaz E The Journal of neuroscience : the official journal of the Society for Neuroscience 27445135 J Neurosci 2016 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/27445135
Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma. Ngo T, Corrales A, Bourne T, Elmojahid S, Lam KS, Díaz E Frontiers in molecular biosciences 30838212 Front Mol Biosci 2019 https://www.ncbi.nlm.nih.gov/pubmed/30838212
Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain. Kirk LM, Ti SW, Bishop HI, Orozco-Llamas M, Pham M, Trimmer JS, Díaz E The Journal of comparative neurology 26660156 J Comp Neurol 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/26660156
DNA microarrays: sample quality control, array hybridization and scanning. Diaz E, Barisone GA Journal of visualized experiments : JoVE 21445042 J Vis Exp 2011 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/21445042
SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Matt L, Kirk LM, Chenaux G, Speca DJ, Puhger KR, Pride MC, Qneibi M, Haham T, Plambeck KE, Stern-Bach Y, Silverman JL, Crawley JN, Hell JW, Díaz E Cell reports 29490264 Cell Rep 2018 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/29490264
Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells. Barisone GA, Satake N, Lewis C, Duong C, Chen C, Lam KS, Nolta J, Dίaz E Blood cells, molecules & diseases 25554682 Blood Cells Mol Dis 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25554682
Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Speca DJ, Trimmer JS, Peterson AS, Díaz E Mammalian genome : official journal of the International Mammalian Genome Society 28894906 Mamm Genome 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28894906
Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. Chenaux G, Matt L, Hill TC, Kaur I, Liu XB, Kirk LM, Speca DJ, McMahon SA, Zito K, Hell JW, Díaz E eNeuro 27800545 eNeuro 2016 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/27800545
Control of Collagen Stability and Heterotrimer Specificity through Repulsive Electrostatic Interactions. Parmar AS, Joshi M, Nosker PL, Hasan NF, Nanda V Biomolecules 24970200 Biomolecules 2013 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/24970200
De novo self-assembling collagen heterotrimers using explicit positive and negative design. Xu F, Zhang L, Koder RL, Nanda V Biochemistry 20170197 Biochemistry 2010 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/20170197
Morphological diversity and polymorphism of self-assembling collagen peptides controlled by length of hydrophobic domains. McGuinness K, Khan IJ, Nanda V ACS nano 25390880 ACS Nano 2014 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/25390880
Dissecting Electrostatic Contributions to Folding and Self-Assembly Using Designed Multicomponent Peptide Systems. Parmar AS, James JK, Grisham DR, Pike DH, Nanda V Journal of the American Chemical Society 26966815 J Am Chem Soc 2016 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/26966815
Circular Dichroism Spectroscopy of Collagen Fibrillogenesis: A New Use for an Old Technique. Drzewiecki KE, Grisham DR, Parmar AS, Nanda V, Shreiber DI Biophysical journal 27926839 Biophys J 2016 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/27926839
Compositional control of higher order assembly using synthetic collagen peptides. Xu F, Li J, Jain V, Tu RS, Huang Q, Nanda V Journal of the American Chemical Society 22171825 J Am Chem Soc 2012 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/22171825
Parallels between DNA and collagen - comparing elastic models of the double and triple helix. Xu F, Zheng H, Clauvelin N, Lu XJ, Olson WK, Nanda V Scientific reports 29038480 Sci Rep 2017 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/29038480
Structural principles for computational and de novo design of 4Fe-4S metalloproteins. Nanda V, Senn S, Pike DH, Rodriguez-Granillo A, Hansen WA, Khare SD, Noy D Biochimica et biophysica acta 26449207 Biochim Biophys Acta 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26449207
Self-assembly of left- and right-handed molecular screws. Xu F, Khan IJ, McGuinness K, Parmar AS, Silva T, Murthy NS, Nanda V Journal of the American Chemical Society 24283407 J Am Chem Soc 2013 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/24283407
Circular permutation directs orthogonal assembly in complex collagen peptide mixtures. Xu F, Silva T, Joshi M, Zahid S, Nanda V The Journal of biological chemistry 24043622 J Biol Chem 2013 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/24043622
Marginal protein stability drives subcellular proteome isoelectric point. Loell K, Nanda V Proceedings of the National Academy of Sciences of the United States of America 30385634 Proc Natl Acad Sci U S A 2018 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/30385634
Hydrodynamic radius coincides with the slip plane position in the electrokinetic behavior of lysozyme. Grisham DR, Nanda V Proteins 29383755 Proteins 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29383755
Computational design of a collagen A:B:C-type heterotrimer. Xu F, Zahid S, Silva T, Nanda V Journal of the American Chemical Society 21902217 J Am Chem Soc 2011 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/21902217
Designing artificial enzymes by intuition and computation. Nanda V, Koder RL Nature chemistry 21124375 Nat Chem 2010 Jan https://www.ncbi.nlm.nih.gov/pubmed/21124375
Sequence recombination improves target specificity in a redesigned collagen peptide abc-type heterotrimer. Giddu S, Xu F, Nanda V Proteins 23042255 Proteins 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23042255
Empirical estimation of local dielectric constants: Toward atomistic design of collagen mimetic peptides. Pike DH, Nanda V Biopolymers 25784456 Biopolymers 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25784456
Metal Stabilization of Collagen and de Novo Designed Mimetic Peptides. Parmar AS, Xu F, Pike DH, Belure SV, Hasan NF, Drzewiecki KE, Shreiber DI, Nanda V Biochemistry 26225466 Biochemistry 2015 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/26225466
Molecular Self-Assembly Strategy for Generating Catalytic Hybrid Polypeptides. Maeda Y, Fang J, Ikezoe Y, Pike DH, Nanda V, Matsui H PloS one 27116246 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27116246
Collagen mimetic peptide discs promote assembly of a broad range of natural protein fibers through hydrophobic interactions. McGuinness K, Nanda V Organic & biomolecular chemistry 28678287 Org Biomol Chem 2017 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/28678287
Zeta Potential Prediction from Protein Structure in General Aqueous Electrolyte Solutions. Grisham DR, Nanda V Langmuir : the ACS journal of surfaces and colloids 33186035 Langmuir 2020 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/33186035
Design of net-charged abc-type collagen heterotrimers. Parmar AS, Zahid S, Belure SV, Young R, Hasan N, Nanda V Journal of structural biology 23603270 J Struct Biol 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/23603270
Methacrylation induces rapid, temperature-dependent, reversible self-assembly of type-I collagen. Drzewiecki KE, Parmar AS, Gaudet ID, Branch JR, Pike DH, Nanda V, Shreiber DI Langmuir : the ACS journal of surfaces and colloids 25208340 Langmuir 2014 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/25208340
Protein-engineered biomaterials: nanoscale mimics of the extracellular matrix. Romano NH, Sengupta D, Chung C, Heilshorn SC Biochimica et biophysica acta 20647034 Biochim Biophys Acta 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/20647034
Complex chemoattractive and chemorepellent Kit signals revealed by direct imaging of murine mast cells in microfluidic gradient chambers. Shamloo A, Manchandia M, Ferreira M, Mani M, Nguyen C, Jahn T, Weinberg K, Heilshorn S Integrative biology : quantitative biosciences from nano to macro 23835699 Integr Biol (Camb) 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23835699
Sequence-specific crosslinking of electrospun, elastin-like protein preserves bioactivity and native-like mechanics. Benitez PL, Sweet JA, Fink H, Chennazhi KP, Nair SV, Enejder A, Heilshorn SC Advanced healthcare materials 23184558 Adv Healthc Mater 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23184558
A microfluidic-based genetic screen to identify microbial virulence factors that inhibit dendritic cell migration. McLaughlin LM, Xu H, Carden SE, Fisher S, Reyes M, Heilshorn SC, Monack DM Integrative biology : quantitative biosciences from nano to macro 24599496 Integr Biol (Camb) 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24599496
Molecular-level engineering of protein physical hydrogels for predictive sol-gel phase behavior. Mulyasasmita W, Lee JS, Heilshorn SC Biomacromolecules 21861461 Biomacromolecules 2011 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/21861461
Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities. Romano NH, Lampe KJ, Xu H, Ferreira MM, Heilshorn SC Small (Weinheim an der Bergstrasse, Germany) 25315156 Small 2015 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/25315156
Microfluidic analysis of extracellular matrix-bFGF crosstalk on primary human myoblast chemoproliferation, chemokinesis, and chemotaxis. Ferreira MM, Dewi RE, Heilshorn SC Integrative biology : quantitative biosciences from nano to macro 25909157 Integr Biol (Camb) 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25909157
Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding. Madl CM, Heilshorn SC Neural regeneration research 26170800 Neural Regen Res 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/26170800
Avidity-controlled delivery of angiogenic peptides from injectable molecular-recognition hydrogels. Mulyasasmita W, Cai L, Hori Y, Heilshorn SC Tissue engineering. Part A 24490588 Tissue Eng Part A 2014 Aug https://www.ncbi.nlm.nih.gov/pubmed/24490588
Chemotaxis of human induced pluripotent stem cell-derived endothelial cells. Huang NF, Dewi RE, Okogbaa J, Lee JC, Jalilrufaihah A, Heilshorn SC, Cooke JP American journal of translational research 23977410 Am J Transl Res 2013 https://www.ncbi.nlm.nih.gov/pubmed/23977410
Photoreactive elastin-like proteins for use as versatile bioactive materials and surface coatings. Raphel J, Parisi-Amon A, Heilshorn S Journal of materials chemistry 23015764 J Mater Chem 2012 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/23015764
Protein-engineered biomaterials to generate human skeletal muscle mimics. Sengupta D, Gilbert PM, Johnson KJ, Blau HM, Heilshorn SC Advanced healthcare materials 23184832 Adv Healthc Mater 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/23184832
Small-molecule axon-polarization studies enabled by a shear-free microfluidic gradient generator. Xu H, Ferreira MM, Heilshorn SC Lab on a chip 24781157 Lab Chip 2014 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/24781157
Avidity-controlled hydrogels for injectable co-delivery of induced pluripotent stem cell-derived endothelial cells and growth factors. Mulyasasmita W, Cai L, Dewi RE, Jha A, Ullmann SD, Luong RH, Huang NF, Heilshorn SC Journal of controlled release : official journal of the Controlled Release Society 24848744 J Control Release 2014 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/24848744
Mechanisms of vascular endothelial growth factor-induced pathfinding by endothelial sprouts in biomaterials. Shamloo A, Xu H, Heilshorn S Tissue engineering. Part A 21888475 Tissue Eng Part A 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/21888475
Building stem cell niches from the molecule up through engineered peptide materials. Lampe KJ, Heilshorn SC Neuroscience letters 22322073 Neurosci Lett 2012 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/22322073
Multifunctional materials through modular protein engineering. DiMarco RL, Heilshorn SC Advanced materials (Deerfield Beach, Fla.) 22730248 Adv Mater 2012 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/22730248
Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ Science (New York, N.Y.) 21071672 Science 2010 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/21071672
Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients. Shamloo A, Heilshorn SC Lab on a chip 20820484 Lab Chip 2010 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/20820484
Hydrogel crosslinking density regulates temporal contractility of human embryonic stem cell-derived cardiomyocytes in 3D cultures. Chung C, Anderson E, Pera RR, Pruitt BL, Heilshorn SC Soft matter 23226161 Soft Matter 2012 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/23226161
Design of three-dimensional engineered protein hydrogels for tailored control of neurite growth. Lampe KJ, Antaris AL, Heilshorn SC Acta biomaterialia 23128159 Acta Biomater 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23128159
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Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1. Pirazzoli V, Nebhan C, Song X, Wurtz A, Walther Z, Cai G, Zhao Z, Jia P, de Stanchina E, Shapiro EM, Gale M, Yin R, Horn L, Carbone DP, Stephens PJ, Miller V, Gettinger S, Pao W, Politi K Cell reports 24813888 Cell Rep 2014 May 22 https://www.ncbi.nlm.nih.gov/pubmed/24813888
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Dual-modality, fluorescent, PLGA encapsulated bismuth nanoparticles for molecular and cellular fluorescence imaging and computed tomography. Swy ER, Schwartz-Duval AS, Shuboni DD, Latourette MT, Mallet CL, Parys M, Cormode DP, Shapiro EM Nanoscale 25248645 Nanoscale 2014 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/25248645
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Self-folding polymeric containers for encapsulation and delivery of drugs. Fernandes R, Gracias DH Advanced drug delivery reviews 22425612 Adv Drug Deliv Rev 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22425612
Three-dimensional microwell arrays for cell culture. Randall CL, Kalinin YV, Jamal M, Manohar T, Gracias DH Lab on a chip 21063585 Lab Chip 2011 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/21063585
Self-folding micropatterned polymeric containers. Azam A, Laflin KE, Jamal M, Fernandes R, Gracias DH Biomedical microdevices 20838901 Biomed Microdevices 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/20838901
Plastic deformation drives wrinkling, saddling, and wedging of annular bilayer nanostructures. Cho JH, Datta D, Park SY, Shenoy VB, Gracias DH Nano letters 21090597 Nano Lett 2010 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/21090597
Three dimensional nanofabrication using surface forces. Cho JH, Azam A, Gracias DH Langmuir : the ACS journal of surfaces and colloids 20507147 Langmuir 2010 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/20507147
Patternable nanowire sensors for electrochemical recording of dopamine. Tyagi P, Postetter D, Saragnese DL, Randall CL, Mirski MA, Gracias DH Analytical chemistry 19904993 Anal Chem 2009 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/19904993
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Three-dimensional chemical patterns for cellular self-organization. Kalinin YV, Randhawa JS, Gracias DH Angewandte Chemie (International ed. in English) 21370335 Angew Chem Int Ed Engl 2011 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/21370335
Silane surface modification for improved bioadhesion of esophageal stents. Karakoy M, Gultepe E, Pandey S, Khashab MA, Gracias DH Applied surface science 25663731 Appl Surf Sci 2014 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/25663731
Self-folding devices and materials for biomedical applications. Randall CL, Gultepe E, Gracias DH Trends in biotechnology 21764161 Trends Biotechnol 2012 Mar https://www.ncbi.nlm.nih.gov/pubmed/21764161
Voltage-gated ion transport through semiconducting conical nanopores formed by metal nanoparticle-assisted plasma etching. James T, Kalinin YV, Chan CC, Randhawa JS, Gaevski M, Gracias DH Nano letters 22725714 Nano Lett 2012 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/22725714
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Directed growth of fibroblasts into three dimensional micropatterned geometries via self-assembling scaffolds. Jamal M, Bassik N, Cho JH, Randall CL, Gracias DH Biomaterials 20022106 Biomaterials 2010 Mar https://www.ncbi.nlm.nih.gov/pubmed/20022106
Biopsy with thermally-responsive untethered microtools. Gultepe E, Randhawa JS, Kadam S, Yamanaka S, Selaru FM, Shin EJ, Kalloo AN, Gracias DH Advanced materials (Deerfield Beach, Fla.) 23047708 Adv Mater 2013 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/23047708
3D printed bionic ears. Mannoor MS, Jiang Z, James T, Kong YL, Malatesta KA, Soboyejo WO, Verma N, Gracias DH, McAlpine MC Nano letters 23635097 Nano Lett 2013 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/23635097
Self-folding thermo-magnetically responsive soft microgrippers. Breger JC, Yoon C, Xiao R, Kwag HR, Wang MO, Fisher JP, Nguyen TD, Gracias DH ACS applied materials & interfaces 25594664 ACS Appl Mater Interfaces 2015 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/25594664
Self-folding single cell grippers. Malachowski K, Jamal M, Jin Q, Polat B, Morris CJ, Gracias DH Nano letters 24937214 Nano Lett 2014 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/24937214
Stimuli-responsive theragrippers for chemomechanical controlled release. Malachowski K, Breger J, Kwag HR, Wang MO, Fisher JP, Selaru FM, Gracias DH Angewandte Chemie (International ed. in English) 24634136 Angew Chem Int Ed Engl 2014 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/24634136
Chemistry with spatial control using particles and streams(). Kalinin YV, Murali A, Gracias DH RSC advances 23145348 RSC Adv 2012 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/23145348
Bio-origami hydrogel scaffolds composed of photocrosslinked PEG bilayers. Jamal M, Kadam SS, Xiao R, Jivan F, Onn TM, Fernandes R, Nguyen TD, Gracias DH Advanced healthcare materials 23386382 Adv Healthc Mater 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23386382
Biopsy using a magnetic capsule endoscope carrying, releasing, and retrieving untethered microgrippers. Yim S, Gultepe E, Gracias DH, Sitti M IEEE transactions on bio-medical engineering 24108454 IEEE Trans Biomed Eng 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24108454
Three-dimensional fabrication at small size scales. Leong TG, Zarafshar AM, Gracias DH Small (Weinheim an der Bergstrasse, Germany) 20349446 Small 2010 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/20349446
Reversible actuation of microstructures by surface-chemical modification of thin-film bilayers. Randhawa JS, Keung MD, Tyagi P, Gracias DH Advanced materials (Deerfield Beach, Fla.) 20217729 Adv Mater 2010 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/20217729
Hierarchical self-assembly of complex polyhedral microcontainers. Filipiak DJ, Azam A, Leong TG, Gracias DH Journal of micromechanics and microengineering : structures, devices, and systems 20161118 J Micromech Microeng 2009 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/20161118
Curving nanostructures using extrinsic stress. Cho JH, James T, Gracias DH Advanced materials (Deerfield Beach, Fla.) 20376856 Adv Mater 2010 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/20376856
Enzymatically triggered actuation of miniaturized tools. Bassik N, Brafman A, Zarafshar AM, Jamal M, Luvsanjav D, Selaru FM, Gracias DH Journal of the American Chemical Society 20849106 J Am Chem Soc 2010 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/20849106
Differentially photo-crosslinked polymers enable self-assembling microfluidics. Jamal M, Zarafshar AM, Gracias DH Nature communications 22068594 Nat Commun 2011 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/22068594
Enabling cargo-carrying bacteria via surface attachment and triggered release. Fernandes R, Zuniga M, Sassine FR, Karakoy M, Gracias DH Small (Weinheim an der Bergstrasse, Germany) 21370460 Small 2011 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/21370460
A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Xu C, Tabebordbar M, Iovino S, Ciarlo C, Liu J, Castiglioni A, Price E, Liu M, Barton ER, Kahn CR, Wagers AJ, Zon LI Cell 24209627 Cell 2013 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/24209627
The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation. Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD Cancer cell 25087979 Cancer Cell 2014 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/25087979
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Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Mayack SR, Shadrach JL, Kim FS, Wagers AJ Nature 20110993 Nature 2010 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/20110993
Rejuvenation of regeneration in the aging central nervous system. Ruckh JM, Zhao JW, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, Franklin RJ Cell stem cell 22226359 Cell Stem Cell 2012 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/22226359
Engineering Escherichia coli into a protein delivery system for mammalian cells. Reeves AZ, Spears WE, Du J, Tan KY, Wagers AJ, Lesser CF ACS synthetic biology 25853840 ACS Synth Biol 2015 May 15 https://www.ncbi.nlm.nih.gov/pubmed/25853840
Young, proliferative thymic epithelial cells engraft and function in aging thymuses. Kim MJ, Miller CM, Shadrach JL, Wagers AJ, Serwold T Journal of immunology (Baltimore, Md. : 1950) 25870244 J Immunol 2015 May 15 https://www.ncbi.nlm.nih.gov/pubmed/25870244
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Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT Cell 23663781 Cell 2013 May 9 https://www.ncbi.nlm.nih.gov/pubmed/23663781
Mutations in Hedgehog pathway genes in fetal rhabdomyomas. Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ The Journal of pathology 23780909 J Pathol 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23780909
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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ Science (New York, N.Y.) 24797481 Science 2014 May 9 https://www.ncbi.nlm.nih.gov/pubmed/24797481
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN Cell reports 23375376 Cell Rep 2013 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/23375376
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High-kappa oxide nanoribbons as gate dielectrics for high mobility top-gated graphene transistors. Liao L, Bai J, Qu Y, Lin YC, Li Y, Huang Y, Duan X Proceedings of the National Academy of Sciences of the United States of America 20308584 Proc Natl Acad Sci U S A 2010 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/20308584
Sub-100 nm channel length graphene transistors. Liao L, Bai J, Cheng R, Lin YC, Jiang S, Qu Y, Huang Y, Duan X Nano letters 20815334 Nano Lett 2010 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/20815334
Very large magnetoresistance in graphene nanoribbons. Bai J, Cheng R, Xiu F, Liao L, Wang M, Shailos A, Wang KL, Huang Y, Duan X Nature nanotechnology 20693988 Nat Nanotechnol 2010 Sep https://www.ncbi.nlm.nih.gov/pubmed/20693988
Graphene-Dielectric Integration for Graphene Transistors. Liao L, Duan X Materials science & engineering. R, Reports : a review journal 21278913 Mater Sci Eng R Rep 2010 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/21278913
High-performance top-gated graphene-nanoribbon transistors using zirconium oxide nanowires as high-dielectric-constant gate dielectrics. Liao L, Bai J, Lin YC, Qu Y, Huang Y, Duan X Advanced materials (Deerfield Beach, Fla.) 20526997 Adv Mater 2010 May 4 https://www.ncbi.nlm.nih.gov/pubmed/20526997
Photocatalytic Properties of Porous Silicon Nanowires. Qu Y, Zhong X, Li Y, Liao L, Huang Y, Duan X Journal of materials chemistry 22190767 J Mater Chem 2010 https://www.ncbi.nlm.nih.gov/pubmed/22190767
Domain wall motion in synthetic Co2Si nanowires. Liu G, Lin YC, Liao L, Liu L, Chen Y, Liu Y, Weiss NO, Zhou H, Huang Y, Duan X Nano letters 22469009 Nano Lett 2012 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/22469009
Porous silicon nanowires. Qu Y, Zhou H, Duan X Nanoscale 21869999 Nanoscale 2011 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/21869999
pH-Operated mechanized porous silicon nanoparticles. Xue M, Zhong X, Shaposhnik Z, Qu Y, Tamanoi F, Duan X, Zink JI Journal of the American Chemical Society 21595466 J Am Chem Soc 2011 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/21595466
Unveiling the formation pathway of single crystalline porous silicon nanowires. Zhong X, Qu Y, Lin YC, Liao L, Duan X ACS applied materials & interfaces 21244020 ACS Appl Mater Interfaces 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21244020
High-capacity silicon-air battery in alkaline solution. Zhong X, Zhang H, Liu Y, Bai J, Liao L, Huang Y, Duan X ChemSusChem 22144348 ChemSusChem 2012 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/22144348
Nanoscale morphology, dimensional control, and electrical properties of oligoanilines. Wang Y, Tran HD, Liao L, Duan X, Kaner RB Journal of the American Chemical Society 20662516 J Am Chem Soc 2010 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/20662516
Highly spectral dependent enhancement of upconversion emission with sputtered gold island films. Zhang H, Xu D, Huang Y, Duan X Chemical communications (Cambridge, England) 21079884 Chem Commun (Camb) 2011 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/21079884
Graphene nanomesh. Bai J, Zhong X, Jiang S, Huang Y, Duan X Nature nanotechnology 20154685 Nat Nanotechnol 2010 Mar https://www.ncbi.nlm.nih.gov/pubmed/20154685
Top-gated graphene nanoribbon transistors with ultrathin high-k dielectrics. Liao L, Bai J, Cheng R, Lin YC, Jiang S, Huang Y, Duan X Nano letters 20380441 Nano Lett 2010 May 12 https://www.ncbi.nlm.nih.gov/pubmed/20380441
Plasmonic modulation of the upconversion fluorescence in NaYF4 :Yb/Tm hexaplate nanocrystals using gold nanoparticles or nanoshells. Zhang H, Li Y, Ivanov IA, Qu Y, Huang Y, Duan X Angewandte Chemie (International ed. in English) 20235253 Angew Chem Int Ed Engl 2010 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/20235253
Rational design and synthesis of freestanding photoelectric nanodevices as highly efficient photocatalysts. Qu Y, Liao L, Cheng R, Wang Y, Lin YC, Huang Y, Duan X Nano letters 20373781 Nano Lett 2010 May 12 https://www.ncbi.nlm.nih.gov/pubmed/20373781
High-speed graphene transistors with a self-aligned nanowire gate. Liao L, Lin YC, Bao M, Cheng R, Bai J, Liu Y, Qu Y, Wang KL, Huang Y, Duan X Nature 20811365 Nature 2010 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/20811365
Single-layer graphene on Al2O3/Si substrate: better contrast and higher performance of graphene transistors. Liao L, Bai J, Qu Y, Huang Y, Duan X Nanotechnology 19946170 Nanotechnology 2010 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/19946170
Rational fabrication of graphene nanoribbons using a nanowire etch mask. Bai J, Duan X, Huang Y Nano letters 19344151 Nano Lett 2009 May https://www.ncbi.nlm.nih.gov/pubmed/19344151
Electrically conductive and optically active porous silicon nanowires. Qu Y, Liao L, Li Y, Zhang H, Huang Y, Duan X Nano letters 19807130 Nano Lett 2009 Dec https://www.ncbi.nlm.nih.gov/pubmed/19807130
Composition tuning the upconversion emission in NaYF4:Yb/Tm hexaplate nanocrystals. Zhang H, Li Y, Lin Y, Huang Y, Duan X Nanoscale 21264435 Nanoscale 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21264435
Heterointegration of Pt/Si/Ag Nanowire Photodiodes and Their Photocatalytic Properties. Qu Y, Xue T, Zhong X, Lin YC, Liao L, Choi J, Duan X Advanced functional materials 21629399 Adv Funct Mater 2010 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/21629399
Plasmonic enhancements of photocatalytic activity of Pt/n-Si/Ag photodiodes using Au/Ag core/shell nanorods. Qu Y, Cheng R, Su Q, Duan X Journal of the American Chemical Society 21961900 J Am Chem Soc 2011 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/21961900
Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Singelyn JM, DeQuach JA, Seif-Naraghi SB, Littlefield RB, Schup-Magoffin PJ, Christman KL Biomaterials 19608268 Biomaterials 2009 Oct https://www.ncbi.nlm.nih.gov/pubmed/19608268
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Injectable biomaterials for adipose tissue engineering. Young DA, Christman KL Biomedical materials (Bristol, England) 22456805 Biomed Mater 2012 Apr https://www.ncbi.nlm.nih.gov/pubmed/22456805
Award winner for outstanding research in the PhD category, 2014 Society for Biomaterials annual meeting and exposition, Denver, Colorado, April 16-19, 2014: Decellularized adipose matrix hydrogels stimulate in vivo neovascularization and adipose formation. Adam Young D, Bajaj V, Christman KL Journal of biomedical materials research. Part A 24510423 J Biomed Mater Res A 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24510423
Fibroblasts influence muscle progenitor differentiation and alignment in contact independent and dependent manners in organized co-culture devices. Rao N, Evans S, Stewart D, Spencer KH, Sheikh F, Hui EE, Christman KL Biomedical microdevices 22983793 Biomed Microdevices 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/22983793
Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model. DeQuach JA, Lin JE, Cam C, Hu D, Salvatore MA, Sheikh F, Christman KL European cells & materials 22665162 Eur Cell Mater 2012 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/22665162
Injectable extracellular matrix derived hydrogel provides a platform for enhanced retention and delivery of a heparin-binding growth factor. Seif-Naraghi SB, Horn D, Schup-Magoffin PJ, Christman KL Acta biomaterialia 22750737 Acta Biomater 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22750737
Modulation of material properties of a decellularized myocardial matrix scaffold. Singelyn JM, Christman KL Macromolecular bioscience 21322109 Macromol Biosci 2011 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/21322109
Human cardiomyogenesis and the need for systems biology analysis. Young DA, DeQuach JA, Christman KL Wiley interdisciplinary reviews. Systems biology and medicine 21197666 Wiley Interdiscip Rev Syst Biol Med 2011 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/21197666
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Comparison of Magnetic Resonance Spectra Acquired With Hybrid PET/MR and Standalone MR Scanners. Macdonald CB, Bhattacharya A, Risk BB, Zuleger TM, Mandava S, Noeske R, Fleischer CC Journal of magnetic resonance imaging : JMRI 40758419 J Magn Reson Imaging 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/40758419
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Estimating muscle activation from EMG using deep learning-based dynamical systems models. Wimalasena LN, Braun JF, Keshtkaran MR, Hofmann D, Gallego JÁ, Alessandro C, Tresch MC, Miller LE, Pandarinath C Journal of neural engineering 35366649 J Neural Eng 2022 May 19 https://www.ncbi.nlm.nih.gov/pubmed/35366649
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Pseudo-linear summation explains neural geometry of multi-finger movements in human premotor cortex. Shah NP, Avansino D, Kamdar F, Nicolas C, Kapitonava A, Vargas-Irwin C, Hochberg LR, Pandarinath C, Shenoy KV, Willett FR, Henderson JM Nature communications 40442062 Nat Commun 2025 May 30 https://www.ncbi.nlm.nih.gov/pubmed/40442062
Computation-through-Dynamics Benchmark: Simulated datasets and quality metrics for dynamical models of neural activity. Versteeg C, McCart JD, Ostrow M, Zoltowski DM, Washington CB, Driscoll L, Codol O, Michaels JA, Linderman SW, Sussillo D, Pandarinath C bioRxiv : the preprint server for biology 39975240 bioRxiv 2025 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/39975240
Myomatrix arrays for high-definition muscle recording. Chung B, Zia M, Thomas KA, Michaels JA, Jacob A, Pack A, Williams MJ, Nagapudi K, Teng LH, Arrambide E, Ouellette L, Oey N, Gibbs R, Anschutz P, Lu J, Wu Y, Kashefi M, Oya T, Kersten R, Mosberger AC, O'Connell S, Wang R, Marques H, Mendes AR, Lenschow C, Kondakath G, Kim JJ, Olson W, Quinn KN, Perkins P, Gatto G, Thanawalla A, Coltman S, Kim T, Smith T, Binder-Markey B, Zaback M, Thompson CK, Giszter S, Person A, Goulding M, Azim E, Thakor N, O'Connor D, Trimmer B, Lima SQ, Carey MR, Pandarinath C, Costa RM, Pruszynski JA, Bakir M, Sober SJ bioRxiv : the preprint server for biology 36865176 bioRxiv 2023 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/36865176
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Identifying Distinct Neural Features between the Initial and Corrective Phases of Precise Reaching Using AutoLFADS. Lee WH, Karpowicz BM, Pandarinath C, Rouse AG The Journal of neuroscience : the official journal of the Society for Neuroscience 38538142 J Neurosci 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/38538142
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Stabilizing brain-computer interfaces through alignment of latent dynamics. Karpowicz BM, Ali YH, Wimalasena LN, Sedler AR, Keshtkaran MR, Bodkin K, Ma X, Rubin DB, Williams ZM, Cash SS, Hochberg LR, Miller LE, Pandarinath C Nature communications 40389429 Nat Commun 2025 May 19 https://www.ncbi.nlm.nih.gov/pubmed/40389429
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DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi S, Sharma N, Ginty DD Cell 37541195 Cell 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37541195
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Enhanced magnetic transduction of neuronal activity by nanofabricated inductors quantified via finite element analysis. Phillips J, Glodowski M, Gokhale Y, Dwyer M, Ashtiani A, Hai A Journal of neural engineering 35705065 J Neural Eng 2022 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/35705065
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Self-Aligned Multilayered Nitrogen Vacancy Diamond Nanoparticles for High Spatial Resolution Magnetometry of Microelectronic Currents. Gokhale Y, Coventry BS, Rogers T, Lines M, Vena A, Phillips J, Zhu T, Bok I, Troche D, Glodowski M, Vareberg A, Bhatt S, Ashtiani AO, Eliceiri KW, Hai A Nano letters 40387807 Nano Lett 2025 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/40387807
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Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus. Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A The Journal of neuroscience : the official journal of the Society for Neuroscience 33762407 J Neurosci 2021 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/33762407
The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases. Lane-Donovan C, Paredes M, Kao AW Progress in neurobiology 41253210 Prog Neurobiol 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41253210
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A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion. Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP Scientific reports 37169815 Sci Rep 2023 May 11 https://www.ncbi.nlm.nih.gov/pubmed/37169815
β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice. Rosenberg MF, Godoy MI, Wade SD, Paredes MF, Zhang Y, Molofsky AV The Journal of neuroscience : the official journal of the Society for Neuroscience 37845031 J Neurosci 2023 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/37845031
Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence. Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC The Journal of neuroscience : the official journal of the Society for Neuroscience 33637558 J Neurosci 2021 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/33637558
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The information bottleneck as a principle underlying multi-area cortical representations during decision-making. Kleinman M, Wang T, Xiao D, Feghhi E, Lee K, Carr N, Li Y, Hadidi N, Chandrasekaran C, Kao JC bioRxiv : the preprint server for biology 37502862 bioRxiv 2025 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/37502862
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A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality. Krishnan S, Dong C, Ratigan H, Morales-Rodriguez D, Cherian C, Sheffield M bioRxiv : the preprint server for biology 39651122 bioRxiv 2025 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/39651122
A Preprocessing Toolbox for 2-Photon Subcellular Calcium Imaging. Jiang A, Zhao C, Sheffield MEJ eNeuro 40360280 eNeuro 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40360280
Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments. Heer CM, Sheffield MEJ bioRxiv : the preprint server for biology 38076843 bioRxiv 2024 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/38076843
Robust genome and cell engineering via in vitro and in situ circularized RNAs. Tong M, Palmer N, Dailamy A, Kumar A, Khaliq H, Han S, Finburgh E, Wing M, Hong C, Xiang Y, Miyasaki K, Portell A, Rainaldi J, Suhardjo A, Nourreddine S, Chew WL, Kwon EJ, Mali P Nature biomedical engineering 39187662 Nat Biomed Eng 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39187662
Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain. Wu JR, Hernandez Y, Miyasaki KF, Kwon EJ Advanced drug delivery reviews 37054953 Adv Drug Deliv Rev 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37054953
Formulation methods for peptide-modified lipid nanoparticles. Miyasaki K, Han S, Carton O, Kandell RM, Gunn J, Kwon EJ Journal of controlled release : official journal of the Controlled Release Society 40645295 J Control Release 2025 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/40645295
Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury. Diaz MD, Kandell RM, Wu JR, Chen A, Christman KL, Kwon EJ Advanced healthcare materials 37390094 Adv Healthc Mater 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37390094
An Activity-Based Nanosensor for Minimally-Invasive Measurement of Protease Activity in Traumatic Brain Injury. Kudryashev JA, Madias MI, Kandell RM, Lin QX, Kwon EJ Advanced functional materials 37873031 Adv Funct Mater 2023 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/37873031
An Activity-Based Nanosensor for Traumatic Brain Injury. Kudryashev JA, Waggoner LE, Leng HT, Mininni NH, Kwon EJ ACS sensors 32100994 ACS Sens 2020 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/32100994
Nanomedicine for Acute Brain Injuries: Insight from Decades of Cancer Nanomedicine. Kandell RM, Waggoner LE, Kwon EJ Molecular pharmaceutics 32584042 Mol Pharm 2021 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/32584042
Pharmacokinetic Analysis of Peptide-Modified Nanoparticles with Engineered Physicochemical Properties in a Mouse Model of Traumatic Brain Injury. Waggoner LE, Madias MI, Hurtado AA, Kwon EJ The AAPS journal 34401968 AAPS J 2021 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/34401968
Impact of Conjugation Chemistry on the Pharmacokinetics of Peptide-Polymer Conjugates in a Model of Traumatic Brain Injury. Wu JR, Canjels A, Miyauchi R, Kwon EJ Bioconjugate chemistry 40577388 Bioconjug Chem 2025 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/40577388
Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury. Waggoner LE, Kang J, Zuidema JM, Vijayakumar S, Hurtado AA, Sailor MJ, Kwon EJ Bioconjugate chemistry 36017941 Bioconjug Chem 2022 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/36017941
Analysis of PEG-lipid anchor length on lipid nanoparticle pharmacokinetics and activity in a mouse model of traumatic brain injury. Waggoner LE, Miyasaki KF, Kwon EJ Biomaterials science 36987922 Biomater Sci 2023 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/36987922
Spatial Measurement and Inhibition of Calpain Activity in Traumatic Brain Injury with an Activity-Based Nanotheranostic Platform. Madias MI, Stessman LN, Warlof SJ, Kudryashev JA, Kwon EJ ACS nano 39236689 ACS Nano 2024 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/39236689
Reprograming Clots for In Vivo Chemical Targeting in Traumatic Brain Injury. Kandell RM, Wu JR, Kwon EJ Advanced materials (Deerfield Beach, Fla.) 38780012 Adv Mater 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38780012
Mechanobiological Modulation of In Vitro Astrocyte Reactivity Using Variable Gel Stiffness. C Benincasa J, Madias MI, Kandell RM, Delgado-Garcia LM, Engler AJ, Kwon EJ, Porcionatto MA ACS biomaterials science & engineering 38870483 ACS Biomater Sci Eng 2024 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/38870483
PEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury. Han S, Yoo W, Carton O, Joo J, Kwon EJ Small (Weinheim an der Bergstrasse, Germany) 39498752 Small 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39498752
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A kinetic-optimized CoChR variant with enhanced high-frequency spiking fidelity. Bi X, Beck C, Gong Y Biophysical journal 36151721 Biophys J 2022 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/36151721
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Segmentation of Neurons from Fluorescence Calcium Recordings Beyond Real-time. Bao Y, Soltanian-Zadeh S, Farsiu S, Gong Y Nature machine intelligence 34485824 Nat Mach Intell 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34485824
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Rational engineering of ratiometric calcium sensors with bright green and red fluorescent proteins. Zhang D, Redington E, Gong Y Communications biology 34326458 Commun Biol 2021 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/34326458
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A high-speed, bright, red fluorescent voltage sensor to detect neural activity. Beck C, Gong Y Scientific reports 31685893 Sci Rep 2019 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/31685893
Identifying properties of pattern completion neurons in a computational model of the visual cortex. Baker CM, Gong Y PLoS computational biology 37279242 PLoS Comput Biol 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37279242
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Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases. Watanabe S, Nihongaki Y, Itoh K, Uyama T, Toda S, Watanabe S, Inoue T Nature communications 35906209 Nat Commun 2022 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/35906209
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Beyond Clathrin: Decoding the Mechanism of Ultrafast Endocytosis. Imoto Y, Watanabe S Physiology (Bethesda, Md.) 40062769 Physiology (Bethesda) 2025 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/40062769
SynapsEM: Computer-Assisted Synapse Morphometry. Watanabe S, Davis MW, Kusick GF, Iwasa J, Jorgensen EM Frontiers in synaptic neuroscience 33390925 Front Synaptic Neurosci 2020 https://www.ncbi.nlm.nih.gov/pubmed/33390925
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons. Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER eLife 34543184 Elife 2021 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/34543184
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ActuAtor, a Listeria-inspired molecular tool for physical manipulation of intracellular organizations through de novo actin polymerization. Nakamura H, Rho E, Lee CT, Itoh K, Deng D, Watanabe S, Razavi S, Matsubayashi HT, Zhu C, Jung E, Rangamani P, Watanabe S, Inoue T Cell reports 37734382 Cell Rep 2023 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/37734382
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Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated Ca(V)2.2 Calcium Channel Activity in Peripheral Axon Terminals Innervating Skin. DuBreuil DM, Lopez Soto EJ, Daste S, Meir R, Li D, Wainger B, Fleischmann A, Lipscombe D The Journal of neuroscience : the official journal of the Society for Neuroscience 34353899 J Neurosci 2021 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/34353899
Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs. Hawrot J, Imhof S, Wainger BJ Neurobiology of disease 31759135 Neurobiol Dis 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31759135
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia. Marques C, Held A, Dorfman K, Sung J, Song C, Kavuturu AS, Aguilar C, Russo T, Oakley DH, Albers MW, Hyman BT, Petrucelli L, Lagier-Tourenne C, Wainger BJ Acta neuropathologica 38478117 Acta Neuropathol 2024 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/38478117
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Corticospinal Modulation of Precision Movements. Marino F, Moreno-López Y, Hollis E Neuroscience insights 38680210 Neurosci Insights 2024 https://www.ncbi.nlm.nih.gov/pubmed/38680210
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Proximity labeling identifies a repertoire of site-specific R-loop modulators. Yan Q, Wulfridge P, Doherty J, Fernandez-Luna JL, Real PJ, Tang HY, Sarma K Nature communications 35013239 Nat Commun 2022 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/35013239
Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach. Yan Q, Shields EJ, Bonasio R, Sarma K Cell reports 31665646 Cell Rep 2019 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/31665646
MapR: A Method for Identifying Native R-Loops Genome Wide. Yan Q, Sarma K Current protocols in molecular biology 31943854 Curr Protoc Mol Biol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31943854
Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Ren W, Medeiros N, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K Nature communications 32376827 Nat Commun 2020 May 6 https://www.ncbi.nlm.nih.gov/pubmed/32376827
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures. Shukla V, Samaniego-Castruita D, Dong Z, González-Avalos E, Yan Q, Sarma K, Rao A Nature immunology 34937926 Nat Immunol 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34937926
Targeted Enhancer Activation by a Subunit of the Integrator Complex. Barbieri E, Trizzino M, Welsh SA, Owens TA, Calabretta B, Carroll M, Sarma K, Gardini A Molecular cell 30008316 Mol Cell 2018 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/30008316
A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide. Wulfridge P, Sarma K eLife 33620319 Elife 2021 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/33620319
Targeted Nuclease Approaches for Mapping Native R-Loops. Wulfridge P, Yan Q, Sarma K Methods in molecular biology (Clifton, N.J.) 35704205 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35704205
ATRX histone binding and helicase activities have distinct roles in neuronal differentiation. Bieluszewska A, Wulfridge P, Doherty J, Ren W, Sarma K Nucleic acids research 35998910 Nucleic Acids Res 2022 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/35998910
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R Nature communications 34493732 Nat Commun 2021 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/34493732
SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia. Han C, Khodadadi-Jamayran A, Lorch AH, Jin Q, Serafin V, Zhu P, Politanska Y, Sun L, Gutierrez-Diaz BT, Pryzhkova MV, Abdala-Valencia H, Bartom ET, Buldini B, Basso G, Velu SE, Sarma K, Mattamana BB, Cho BK, Obeng RC, Goo YA, Jordan PW, Tsirigos A, Zhou Y, Ntziachristos P Science advances 35061527 Sci Adv 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/35061527
G-quadruplexes associated with R-loops promote CTCF binding. Wulfridge P, Yan Q, Rell N, Doherty J, Jacobson S, Offley S, Deliard S, Feng K, Phillips-Cremins JE, Gardini A, Sarma K Molecular cell 37552993 Mol Cell 2023 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/37552993
The Cerebellar Nuclei and Dexterous Limb Movements. Thanawalla AR, Chen AI, Azim E Neuroscience 32652173 Neuroscience 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/32652173
Proprioception. Tuthill JC, Azim E Current biology : CB 29510103 Curr Biol 2018 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/29510103
Modulation of tactile feedback for the execution of dexterous movement. Conner JM, Bohannon A, Igarashi M, Taniguchi J, Baltar N, Azim E Science (New York, N.Y.) 34648327 Science 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34648327
The dorsal column nuclei scale mechanical sensitivity in naive and neuropathic pain states. Upadhyay A, Gradwell MA, Vajtay TJ, Conner J, Sanyal AA, Azadegan C, Patel KR, Thackray JK, Bohic M, Imai F, Ogundare SO, Yoshida Y, Abdus-Saboor I, Azim E, Abraira VE Cell reports 40202848 Cell Rep 2025 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/40202848
Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models. Butler DJ, Keim AP, Ray S, Azim E Nature communications 37752123 Nat Commun 2023 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/37752123
Gain control in the sensorimotor system. Azim E, Seki K Current opinion in physiology 31403088 Curr Opin Physiol 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/31403088
Reverse-translational identification of a cerebellar satiation network. Low AYT, Goldstein N, Gaunt JR, Huang KP, Zainolabidin N, Yip AKK, Carty JRE, Choi JY, Miller AM, Ho HST, Lenherr C, Baltar N, Azim E, Sessions OM, Ch'ng TH, Bruce AS, Martin LE, Halko MA, Brady RO Jr, Holsen LM, Alhadeff AL, Chen AI, Betley JN Nature 34789878 Nature 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34789878
Anipose: A toolkit for robust markerless 3D pose estimation. Karashchuk P, Rupp KL, Dickinson ES, Walling-Bell S, Sanders E, Azim E, Brunton BW, Tuthill JC Cell reports 34592148 Cell Rep 2021 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/34592148
Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity. Lustig J, Lammers A, Kaiser J, Patel P, Raghu A, Conner JM, Nguyen P, Azim E, Sahni V bioRxiv : the preprint server for biology 39713479 bioRxiv 2024 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/39713479
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The Sensorimotor Basis of Whisker-Guided Anteroposterior Object Localization in Head-Fixed Mice. Cheung J, Maire P, Kim J, Sy J, Hires SA Current biology : CB 31474537 Curr Biol 2019 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/31474537
Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice. Kim J, Erskine A, Cheung JA, Hires SA Neuron 33002411 Neuron 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33002411
Dynamic cues for whisker-based object localization: An analytical solution to vibration during active whisker touch. Vaxenburg R, Wyche I, Svoboda K, Efros AL, Hires SA PLoS computational biology 29584719 PLoS Comput Biol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29584719
Posterior amygdala regulates sexual and aggressive behaviors in male mice. Yamaguchi T, Wei D, Song SC, Lim B, Tritsch NX, Lin D Nature neuroscience 32719562 Nat Neurosci 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32719562
Subsecond dopamine fluctuations do not specify the vigor of ongoing actions. Liu H, Melani R, Maltese M, Taniguchi J, Sankaramanchi A, Zeng R, Martin JR, Tritsch NX Nature neuroscience 41214177 Nat Neurosci 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41214177
G protein-coupled receptors cooperate to silence dopamine neurons. Liu H, Tritsch NX The Journal of physiology 36214545 J Physiol 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36214545
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Unraveling the dynamics of dopamine release and its actions on target cells. Sippy T, Tritsch NX Trends in neurosciences 36635111 Trends Neurosci 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36635111
Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice. Longo F, Aryal S, Anastasiades PG, Maltese M, Baimel C, Albanese F, Tabor J, Zhu JD, Oliveira MM, Gastaldo D, Bagni C, Santini E, Tritsch NX, Carter AG, Klann E Cell reports 37505982 Cell Rep 2023 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/37505982
GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABA(A) receptors. Patel JC, Sherpa AD, Melani R, Witkovsky P, Wiseman MR, O'Neill B, Aoki C, Tritsch NX, Rice ME Cell reports 38431842 Cell Rep 2024 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/38431842
A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors. Fang YY, Yamaguchi T, Song SC, Tritsch NX, Lin D Neuron 29621487 Neuron 2018 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/29621487
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Acetylcholine waves and dopamine release in the striatum. Matityahu L, Gilin N, Sarpong GA, Atamna Y, Tiroshi L, Tritsch NX, Wickens JR, Goldberg JA Nature communications 37891198 Nat Commun 2023 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/37891198
Intrinsic dopamine and acetylcholine dynamics in the striatum of mice. Krok AC, Maltese M, Mistry P, Miao X, Li Y, Tritsch NX Nature 37558873 Nature 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37558873
Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation. Lee YV, Tian B Nano letters 30888185 Nano Lett 2019 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/30888185
Nongenetic optical neuromodulation with silicon-based materials. Jiang Y, Parameswaran R, Li X, Carvalho-de-Souza JL, Gao X, Meng L, Bezanilla F, Shepherd GMG, Tian B Nature protocols 30980031 Nat Protoc 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30980031
Inorganic semiconductor biointerfaces. Jiang Y, Tian B Nature reviews. Materials 31656635 Nat Rev Mater 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/31656635
Living myofibroblast-silicon composites for probing electrical coupling in cardiac systems. Rotenberg MY, Yamamoto N, Schaumann EN, Matino L, Santoro F, Tian B Proceedings of the National Academy of Sciences of the United States of America 31624124 Proc Natl Acad Sci U S A 2019 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/31624124
Nano-enabled cellular engineering for bioelectric studies. Shi J, Clayton C, Tian B Nano research 34295455 Nano Res 2020 May https://www.ncbi.nlm.nih.gov/pubmed/34295455
Biological Interfaces, Modulation, and Sensing with Inorganic Nano-Bioelectronic Materials. Schaumann EN, Tian B Small methods 34295965 Small Methods 2020 May 11 https://www.ncbi.nlm.nih.gov/pubmed/34295965
Rational design of silicon structures for optically controlled multiscale biointerfaces. Jiang Y, Li X, Liu B, Yi J, Fang Y, Shi F, Gao X, Sudzilovsky E, Parameswaran R, Koehler K, Nair V, Yue J, Guo K, Fang Y, Tsai HM, Freyermuth G, Wong RCS, Kao CM, Chen CT, Nicholls AW, Wu X, Shepherd GMG, Tian B Nature biomedical engineering 30906646 Nat Biomed Eng 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/30906646
An atlas of nano-enabled neural interfaces. Acarón Ledesma H, Li X, Carvalho-de-Souza JL, Wei W, Bezanilla F, Tian B Nature nanotechnology 31270446 Nat Nanotechnol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31270446
Dissecting Biological and Synthetic Soft-Hard Interfaces for Tissue-Like Systems. Fang Y, Yang X, Lin Y, Shi J, Prominski A, Clayton C, Ostroff E, Tian B Chemical reviews 34677943 Chem Rev 2022 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/34677943
Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces. Fang Y, Prominski A, Rotenberg MY, Meng L, Acarón Ledesma H, Lv Y, Yue J, Schaumann E, Jeong J, Yamamoto N, Jiang Y, Elbaz B, Wei W, Tian B Nature nanotechnology 33288948 Nat Nanotechnol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33288948
Laser writing of nitrogen-doped silicon carbide for biological modulation. Nair V, Yi J, Isheim D, Rotenberg M, Meng L, Shi F, Chen X, Gao X, Prominski A, Jiang Y, Yue J, Gallagher CT, Seidman DN, Tian B Science advances 32937377 Sci Adv 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32937377
Silicon Nanowires for Intracellular Optical Interrogation with Subcellular Resolution. Rotenberg MY, Elbaz B, Nair V, Schaumann EN, Yamamoto N, Sarma N, Matino L, Santoro F, Tian B Nano letters 31904975 Nano Lett 2020 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/31904975
Alloy-assisted deposition of three-dimensional arrays of atomic gold catalyst for crystal growth studies. Fang Y, Jiang Y, Cherukara MJ, Shi F, Koehler K, Freyermuth G, Isheim D, Narayanan B, Nicholls AW, Seidman DN, Sankaranarayanan SKRS, Tian B Nature communications 29222439 Nat Commun 2017 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/29222439
Soft-Hard Composites for Bioelectric Interfaces. Lin Y, Fang Y, Yue J, Tian B Trends in chemistry 34296076 Trends Chem 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/34296076
Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. Lee YV, Wu D, Fang Y, Peng Y, Tian B Nano letters 32208712 Nano Lett 2020 May 13 https://www.ncbi.nlm.nih.gov/pubmed/32208712
Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix. Parameswaran R, Koehler K, Rotenberg MY, Burke MJ, Kim J, Jeong KY, Hissa B, Paul MD, Moreno K, Sarma N, Hayes T, Sudzilovsky E, Park HG, Tian B Proceedings of the National Academy of Sciences of the United States of America 30538202 Proc Natl Acad Sci U S A 2019 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/30538202
Recent advances in bioelectronics chemistry. Fang Y , Meng L , Prominski A , Schaumann EN , Seebald M , Tian B Chemical Society reviews 32672777 Chem Soc Rev 2020 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/32672777
Texturing Silicon Nanowires for Highly Localized Optical Modulation of Cellular Dynamics. Fang Y, Jiang Y, Acaron Ledesma H, Yi J, Gao X, Weiss DE, Shi F, Tian B Nano letters 29894630 Nano Lett 2018 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/29894630
Nongenetic Optical Methods for Measuring and Modulating Neuronal Response. Zimmerman JF, Tian B ACS nano 29727159 ACS Nano 2018 May 22 https://www.ncbi.nlm.nih.gov/pubmed/29727159
Talking to cells: semiconductor nanomaterials at the cellular interface. Rotenberg MY, Tian B Advanced biosystems 30906852 Adv Biosyst 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/30906852
Biomimetic Approaches Toward Smart Bio-hybrid Systems. Luo Z, Weiss DE, Liu Q, Tian B Nano research 30906509 Nano Res 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/30906509
Nanowired Bioelectric Interfaces. Tian B, Lieber CM Chemical reviews 30995019 Chem Rev 2019 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/30995019
Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires. Parameswaran R, Carvalho-de-Souza JL, Jiang Y, Burke MJ, Zimmerman JF, Koehler K, Phillips AW, Yi J, Adams EJ, Bezanilla F, Tian B Nature nanotechnology 29459654 Nat Nanotechnol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29459654
Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons. Campbell EP, Abushawish AA, Valdez LA, Bell MK, Haryono M, Rangamani P, Bloodgood BL Cell reports 36640310 Cell Rep 2023 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/36640310
Acoustic Pattern Recognition and Courtship Songs: Insights from Insects. Baker CA, Clemens J, Murthy M Annual review of neuroscience 30786225 Annu Rev Neurosci 2019 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/30786225
Quantifying behavior to solve sensorimotor transformations: advances from worms and flies. Calhoun AJ, Murthy M Current opinion in neurobiology 28850885 Curr Opin Neurobiol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28850885
Experimental and statistical reevaluation provides no evidence for Drosophila courtship song rhythms. Stern DL, Clemens J, Coen P, Calhoun AJ, Hogenesch JB, Arthur BJ, Murthy M Proceedings of the National Academy of Sciences of the United States of America 28851830 Proc Natl Acad Sci U S A 2017 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/28851830
Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression. Crocker A, Guan XJ, Murphy CT, Murthy M Cell reports 27160913 Cell Rep 2016 May 17 https://www.ncbi.nlm.nih.gov/pubmed/27160913
Auditory activity is diverse and widespread throughout the central brain of Drosophila. Pacheco DA, Thiberge SY, Pnevmatikakis E, Murthy M Nature neuroscience 33230320 Nat Neurosci 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33230320
Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors. Deutsch D, Clemens J, Thiberge SY, Guan G, Murthy M Current biology : CB 31564492 Curr Biol 2019 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/31564492
Connecting Neural Codes with Behavior in the Auditory System of Drosophila. Clemens J, Girardin CC, Coen P, Guan XJ, Dickson BJ, Murthy M Neuron 26365767 Neuron 2015 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/26365767
Singing on the fly: sensorimotor integration and acoustic communication in Drosophila. Coen P, Murthy M Current opinion in neurobiology 26874218 Curr Opin Neurobiol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26874218
Sensorimotor Transformations Underlying Variability in Song Intensity during Drosophila Courtship. Coen P, Xie M, Clemens J, Murthy M Neuron 26844835 Neuron 2016 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/26844835
Fast intensity adaptation enhances the encoding of sound in Drosophila. Clemens J, Ozeri-Engelhard N, Murthy M Nature communications 29317624 Nat Commun 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29317624
Discovery of a New Song Mode in Drosophila Reveals Hidden Structure in the Sensory and Neural Drivers of Behavior. Clemens J, Coen P, Roemschied FA, Pereira TD, Mazumder D, Aldarondo DE, Pacheco DA, Murthy M Current biology : CB 30057309 Curr Biol 2018 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/30057309
Neural network organization for courtship-song feature detection in Drosophila. Baker CA, McKellar C, Pang R, Nern A, Dorkenwald S, Pacheco DA, Eckstein N, Funke J, Dickson BJ, Murthy M Current biology : CB 35793679 Curr Biol 2022 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/35793679
Directed evolution of a far-red fluorescent rhodopsin. McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH Proceedings of the National Academy of Sciences of the United States of America 25157169 Proc Natl Acad Sci U S A 2014 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/25157169
Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research. Robinson JE, Gradinaru V Current opinion in neurobiology 28850815 Curr Opin Neurobiol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/28850815
Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology? Greenbaum A, Jang MJ, Challis C, Gradinaru V BMC biology 28946882 BMC Biol 2017 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/28946882
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Challis C, Hori A, Sampson TR, Yoo BB, Challis RC, Hamilton AM, Mazmanian SK, Volpicelli-Daley LA, Gradinaru V Nature neuroscience 32066981 Nat Neurosci 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32066981
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics. Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH Nature methods 31611694 Nat Methods 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31611694
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types. Ravindra Kumar S, Miles TF, Chen X, Brown D, Dobreva T, Huang Q, Ding X, Luo Y, Einarsson PH, Greenbaum A, Jang MJ, Deverman BE, Gradinaru V Nature methods 32313222 Nat Methods 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32313222
Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V Chemistry & biology 26211362 Chem Biol 2015 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/26211362
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses. Kahan A, Greenbaum A, Jang MJ, Robinson JE, Cho JR, Chen X, Kassraian P, Wagenaar DA, Gradinaru V Cell reports 34592157 Cell Rep 2021 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/34592157
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Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, Deverman BE, Münzberg H, Ardell JL, Salama G, Gradinaru V, Shivkumar K Nature communications 31028266 Nat Commun 2019 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/31028266
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Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V Nature neuroscience 28671695 Nat Neurosci 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28671695
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Using machine learning with passive wearable sensors to pilot the detection of eating disorder behaviors in everyday life. Ralph-Nearman C, Sandoval-Araujo LE, Karem A, Cusack CE, Glatt S, Hooper MA, Rodriguez Pena C, Cohen D, Allen S, Cash ED, Welch K, Levinson CA Psychological medicine 37859600 Psychol Med 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/37859600
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Super-resolved, three-dimensional spatial transcriptomics reveals cell-type and brain-region-specific modulation of key epitranscriptomic switches following adolescent alcohol exposure. Tandukar J, Islam A, Malovic E, Afzal B, Zhang H, Pandey SC, Gao R bioRxiv : the preprint server for biology 41648353 bioRxiv 2026 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/41648353
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Re-evaluating National Suicide Prevention Month: Strategic Timing and Enhanced Impact. Ward JM, Yang A, Shi Y, Haydinger A, Blosnich JR Critical public health 40741523 Crit Public Health 2025 https://www.ncbi.nlm.nih.gov/pubmed/40741523
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Adverse Childhood Experiences Among Lesbian, Gay, Bisexual, and Queer Veterans. Hahn HA, Blosnich JR American journal of preventive medicine 37037327 Am J Prev Med 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37037327
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Exploring Bankruptcy Attorneys' Experiences With Clients Exhibiting Suicidality: Challenges and Recommendations for Suicide Prevention. Blosnich JR, Ward JM, Perkins M, Ding M, De Luca S Behavioral sciences & the law 41431169 Behav Sci Law 2026 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/41431169
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Arousal and Locomotion Differently Modulate Activity of Somatostatin Neurons across Cortex. Khoury CF, Fala NG, Runyan CA eNeuro 37169583 eNeuro 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37169583
Simultaneous interneuron labeling reveals cell type-specific, population-level interactions in cortex. Potter CT, Bassi CD, Runyan CA iScience 39280622 iScience 2024 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/39280622
The spatial scale of somatostatin subnetworks increases from sensory to association cortex. Khoury CF, Fala NG, Runyan CA Cell reports 36070697 Cell Rep 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/36070697
Parietal cortex is causally required for state-dependent decisions. Bandi AC, McCann JP, Carpenter RM, Lower MJ, Long JN, Runyan CA Cell reports 41389207 Cell Rep 2025 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/41389207
Local Differences in Network Organization in the Auditory and Parietal Cortex, Revealed with Single Neuron Activation. Khoury CF, Ferrone M, Runyan CA The Journal of neuroscience : the official journal of the Society for Neuroscience 39890466 J Neurosci 2025 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/39890466
Parietal cortex is causally required for state-dependent decisions. Bandi AC, McCann JP, Carpenter RM, Lower MJ, Long JN, Runyan CA bioRxiv : the preprint server for biology 38826351 bioRxiv 2025 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/38826351
Focus on your locus with a massively parallel reporter assay. McAfee JC, Bell JL, Krupa O, Matoba N, Stein JL, Won H Journal of neurodevelopmental disorders 36085003 J Neurodev Disord 2022 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/36085003
Annotating genetic variants to target genes using H-MAGMA. Sey NYA, Pratt BM, Won H Nature protocols 36289406 Nat Protoc 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36289406
Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review. Raznahan A, Won H, Glahn DC, Jacquemont S JAMA psychiatry 35767289 JAMA Psychiatry 2022 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/35767289
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. Hu B, Won H, Mah W, Park RB, Kassim B, Spiess K, Kozlenkov A, Crowley CA, Pochareddy S, PsychENCODE Consortium, Li Y, Dracheva S, Sestan N, Akbarian S, Geschwind DH Nature communications 34172755 Nat Commun 2021 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/34172755
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB Nature communications 33144568 Nat Commun 2020 Nov 3 https://www.ncbi.nlm.nih.gov/pubmed/33144568
Limited Association between Schizophrenia Genetic Risk Factors and Transcriptomic Features. Yu AW, Peery JD, Won H Genes 34356078 Genes (Basel) 2021 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/34356078
Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features. Bond ML, Davis ES, Quiroga IY, Dey A, Kiran M, Love MI, Won H, Phanstiel DH Genome research 37699658 Genome Res 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37699658
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants. McAfee JC, Lee S, Lee J, Bell JL, Krupa O, Davis J, Insigne K, Bond ML, Zhao N, Boyle AP, Phanstiel DH, Love MI, Stein JL, Ruzicka WB, Davila-Velderrain J, Kosuri S, Won H Cell genomics 37868037 Cell Genom 2023 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/37868037
Advances in profiling chromatin architecture shed light on the regulatory dynamics underlying brain disorders. Pratt BM, Won H Seminars in cell & developmental biology 34483043 Semin Cell Dev Biol 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34483043
Regulatory landscape in brain development and disease. Spiess K, Won H Current opinion in genetics & development 32563855 Curr Opin Genet Dev 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32563855
Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Ramaswami G, Won H, Gandal MJ, Haney J, Wang JC, Wong CCY, Sun W, Prabhakar S, Mill J, Geschwind DH Nature communications 32978376 Nat Commun 2020 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/32978376
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development. Liu D, Zinski A, Mishra A, Noh H, Park GH, Qin Y, Olorife O, Park JM, Abani CP, Park JS, Fung J, Sawaqed F, Coyle JT, Stahl E, Bendl J, Fullard JF, Roussos P, Zhang X, Stanton PK, Yin C, Huang W, Kim HY, Won H, Cho JH, Chung S Molecular psychiatry 35701597 Mol Psychiatry 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35701597
Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia. Wen J, Trost B, Engchuan W, Halvorsen M, Pallotto LM, Mitina A, Ancalade N, Farrell M, Backstrom I, Guo K, Pellecchia G, Thiruvahindrapuram B, Giusti-Rodriguez P, Rosen JD, Li Y, Won H, Magnusson PKE, Gyllensten U, Bassett AS, Hultman CM, Sullivan PF, Yuen RKC, Szatkiewicz JP Molecular psychiatry 36380236 Mol Psychiatry 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36380236
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders. Lee S, McAfee JC, Lee J, Gomez A, Ledford AT, Clarke D, Min H, Gerstein MB, Boyle AP, Sullivan PF, Beltran AS, Won H Cell 39848247 Cell 2025 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/39848247
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Sey NYA, Hu B, Mah W, Fauni H, McAfee JC, Rajarajan P, Brennand KJ, Akbarian S, Won H Nature neuroscience 32152537 Nat Neurosci 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32152537
Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Sey NYA, Hu B, Iskhakova M, Lee S, Sun H, Shokrian N, Ben Hutta G, Marks JA, Quach BC, Johnson EO, Hancock DB, Akbarian S, Won H Molecular psychiatry 35422469 Mol Psychiatry 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35422469
Common genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism. Matoba N, Liang D, Sun H, Aygün N, McAfee JC, Davis JE, Raffield LM, Qian H, Piven J, Li Y, Kosuri S, Won H, Stein JL Translational psychiatry 32747698 Transl Psychiatry 2020 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/32747698
Chromatin architecture provides a roadmap to improve our understanding of psychiatric disorders. Hu B, Won H Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 32859998 Neuropsychopharmacology 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32859998
Schizophrenia-Linked Protein tSNARE1 Regulates Endosomal Trafficking in Cortical Neurons. Plooster M, Rossi G, Farrell MS, McAfee JC, Bell JL, Ye M, Diering GH, Won H, Gupton SL, Brennwald P The Journal of neuroscience : the official journal of the Society for Neuroscience 34642214 J Neurosci 2021 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/34642214
HIV integration in the human brain is linked to microglial activation and 3D genome remodeling. Plaza-Jennings AL, Valada A, O'Shea C, Iskhakova M, Hu B, Javidfar B, Ben Hutta G, Lambert TY, Murray J, Kassim B, Chandrasekaran S, Chen BK, Morgello S, Won H, Akbarian S Molecular cell 36525955 Mol Cell 2022 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/36525955
Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex. Liu S, Won H, Clarke D, Matoba N, Khullar S, Mu Y, Wang D, Gerstein M Genome medicine 36424644 Genome Med 2022 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/36424644
The preference for sugar over sweetener depends on a gut sensor cell. Buchanan KL, Rupprecht LE, Kaelberer MM, Sahasrabudhe A, Klein ME, Villalobos JA, Liu WW, Yang A, Gelman J, Park S, Anikeeva P, Bohórquez DV Nature neuroscience 35027761 Nat Neurosci 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35027761
The Crunchometer: A Low-Cost, Open-Source Acoustic Analysis of Feeding Microstructure. Gil-Lievana E, Arroyo B, Pérez-Ortega J, Lopez A, Rodriguez Blanco LA, Diaz X, Hernandez G, Coss A, Alway E, Reicher N, Lemus EH, Kaelberer M, Bohórquez DV, Gutierrez R bioRxiv : the preprint server for biology 40766613 bioRxiv 2025 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/40766613
The neural basis of sugar preference. Liu WW, Bohórquez DV Nature reviews. Neuroscience 35879409 Nat Rev Neurosci 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35879409
Deciphering visceral instincts: a scientific quest to unravel food choices from molecules to mind. Alway E, Reicher N, Bohórquez DV Genes & development 39362782 Genes Dev 2024 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/39362782
The nerve not taken. Rupprecht LE, Bohórquez DV Cell metabolism 33657390 Cell Metab 2021 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/33657390
Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction. Kaelberer MM, Rupprecht LE, Liu WW, Weng P, Bohórquez DV Annual review of neuroscience 32101483 Annu Rev Neurosci 2020 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/32101483
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Interfacing behavioral and neural circuit models for habit formation. Lerner TN Journal of neuroscience research 31916623 J Neurosci Res 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/31916623
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Editorial: Dopamine Neuron Diversity in Circuits and Diseases. Poulin JF, Lerner TN, Howe MW Frontiers in neural circuits 35310549 Front Neural Circuits 2022 https://www.ncbi.nlm.nih.gov/pubmed/35310549
Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning. Lopez GC, Van Camp LD, Kovaleski RF, Schaid MD, Sherathiya VN, Cox JM, Lerner TN Current biology : CB 40267916 Curr Biol 2025 May 19 https://www.ncbi.nlm.nih.gov/pubmed/40267916
Dopamine signaling in the dorsomedial striatum promotes compulsive behavior. Seiler JL, Cosme CV, Sherathiya VN, Schaid MD, Bianco JM, Bridgemohan AS, Lerner TN Current biology : CB 35134327 Curr Biol 2022 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/35134327
GuPPy, a Python toolbox for the analysis of fiber photometry data. Sherathiya VN, Schaid MD, Seiler JL, Lopez GC, Lerner TN Scientific reports 34930955 Sci Rep 2021 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/34930955
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Hidden variables in stress neurobiology research. Holloway AL, Lerner TN Trends in neurosciences 37985263 Trends Neurosci 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37985263
Reverse engineering human brain evolution using organoid models. Mostajo-Radji MA, Schmitz MT, Montoya ST, Pollen AA Brain research 31809699 Brain Res 2020 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/31809699
Accelerated Tempo of Cortical Neurogenesis in Down Syndrome. Ding JW, Kim CN, Steyert MR, Yuan AT, Shin D, Ivanov D, Nowakowski TJ, Pollen AA bioRxiv : the preprint server for biology 41256555 bioRxiv 2025 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/41256555
Mapping cis- and trans-regulatory target genes of human-specific deletions. Fair T, Pavlovic BJ, Swope D, Castillo OE, Schaefer NK, Pollen AA bioRxiv : the preprint server for biology 38234800 bioRxiv 2024 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/38234800
Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability. Nolbrant S, Wallace JL, Ding JW, Zhu T, Sevetson JL, Kajtez J, Baldacci IA, Corrigan EK, Hoglin K, McMullen R, Ostrowski MS, Schmitz MT, Breevoort A, Swope D, Wu F, Pavlovic BJ, Salama SR, Kirkeby A, Huang H, Schaefer NK, Pollen AA bioRxiv : the preprint server for biology 39605599 bioRxiv 2025 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/39605599
CellBouncer, A Unified Toolkit for Single-Cell Demultiplexing and Ambient RNA Analysis, Reveals Hominid Mitochondrial Incompatibilities. Schaefer NK, Pavlovic BJ, Pollen AA bioRxiv : the preprint server for biology 40166335 bioRxiv 2025 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/40166335
UCSC Cell Browser: visualize your single-cell data. Speir ML, Bhaduri A, Markov NS, Moreno P, Nowakowski TJ, Papatheodorou I, Pollen AA, Raney BJ, Seninge L, Kent WJ, Haeussler M Bioinformatics (Oxford, England) 34244710 Bioinformatics 2021 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/34244710
Three-dimensional genome rewiring in loci with human accelerated regions. Keough KC, Whalen S, Inoue F, Przytycki PF, Fair T, Deng C, Steyert M, Ryu H, Lindblad-Toh K, Karlsson E, Zoonomia Consortium§, Nowakowski T, Ahituv N, Pollen A, Pollard KS Science (New York, N.Y.) 37104607 Science 2023 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/37104607
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Massively parallel characterization of regulatory elements in the developing human cortex. Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM, PsychENCODE Consortium‡, Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS, PsychENCODE Consortium Science (New York, N.Y.) 38781390 Science 2024 May 24 https://www.ncbi.nlm.nih.gov/pubmed/38781390
Dissecting gene regulatory networks governing human cortical cell fate. Ding JW, Kim CN, Ostrowski MS, Abeykoon Y, Pavlovic BJ, Wallace JL, Schaefer NK, Nowakowski TJ, Pollen AA Nature 41565813 Nature 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41565813
Comparative landscape of genetic dependencies in human and chimpanzee stem cells. She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA bioRxiv : the preprint server for biology 36993685 bioRxiv 2023 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/36993685
Genetic architecture of human brain evolution. Fair T, Pollen AA Current opinion in neurobiology 37003107 Curr Opin Neurobiol 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37003107
Machine learning dissection of human accelerated regions in primate neurodevelopment. Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, Kriegstein A, Rubenstein JL, Shendure J, Pollen AA, Ahituv N, Pollard KS Neuron 36640767 Neuron 2023 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36640767
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Interrogating the Regulatory Function of HAQERs during Human Cortical Development. Abeykoon Y, Dzikowski N, Luo Y, Sinniah E, Weaver S, Pavlovic BJ, Wallace JL, Mangan RJ, Lowe CB, Pollen AA bioRxiv : the preprint server for biology 41377512 bioRxiv 2025 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/41377512
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A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies. Durand-de Cuttoli R, Martínez-Rivera FJ, Li L, Minier-Toribio A, Dong Z, Cai DJ, Russo SJ, Nestler EJ, Sweis BM Biological psychiatry 38141911 Biol Psychiatry 2024 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/38141911
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Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior. Pennington ZT, LaBanca AR, Sompolpong P, Abdel-Raheim SD, Ko B, Christenson Wick Z, Feng Y, Dong Z, Francisco TR, Bacon ME, Chen L, Fulton SL, Maze I, Shuman T, Cai DJ bioRxiv : the preprint server for biology 36945605 bioRxiv 2024 May 8 https://www.ncbi.nlm.nih.gov/pubmed/36945605
Ensemble-specific deficit in neuronal intrinsic excitability in aged mice. Chen L, Francisco TR, Baggetta AM, Zaki Y, Ramirez S, Clem RL, Shuman T, Cai DJ Neurobiology of aging 36652783 Neurobiol Aging 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36652783
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy. Feng Y, Diego KS, Dong Z, Wick ZC, Page-Harley L, Page-Harley V, Schnipper J, Lamsifer SI, Pennington ZT, Vetere LM, Philipsberg PA, Soler I, Jurkowski A, Rosado CJ, Khan NN, Cai DJ, Shuman T bioRxiv : the preprint server for biology 38559224 bioRxiv 2024 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/38559224
Simultaneous two-color imaging with a dual-channel miniscope in freely behaving mice. Dong Z, Feng Y, Diego K, Baggetta AM, Sweis BM, Pennington ZT, Lamsifer SI, Zaki Y, Sangiuliano F, Philipsberg PA, Morales-Rodriguez D, Kircher D, Slesinger P, Shuman T, Aharoni D, Cai DJ Science advances 40601747 Sci Adv 2025 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/40601747
Interneuron theta phase locking controls seizure susceptibility. Wick ZC, Philipsberg PA, Kohler C, Lamsifer SI, Katanov E, Adam CD, Gordon KE, Feng Y, Vetere LM, Donnelly GC, Humphrey C, Cai DJ, Shuman T bioRxiv : the preprint server for biology 40964369 bioRxiv 2025 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/40964369
Minian, an open-source miniscope analysis pipeline. Dong Z, Mau W, Feng Y, Pennington ZT, Chen L, Zaki Y, Rajan K, Shuman T, Aharoni D, Cai DJ eLife 35642786 Elife 2022 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/35642786
A distinct signaling pathway in parvalbumin-positive interneurons controls flexible memory updating. Cai DJ, Shuman T Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 35236915 Neuropsychopharmacology 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35236915
Memory engram stability and flexibility. Zaki Y, Cai DJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 39300271 Neuropsychopharmacology 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39300271
Progressive Excitability Changes in the Medial Entorhinal Cortex in the 3xTg Mouse Model of Alzheimer's Disease Pathology. Chen L, Christenson Wick Z, Vetere LM, Vaughan N, Jurkowski A, Galas A, Diego KS, Philipsberg PA, Soler I, Feng Y, Cai DJ, Shuman T The Journal of neuroscience : the official journal of the Society for Neuroscience 37714705 J Neurosci 2023 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/37714705
Chronotate: An open-source tool for manual timestamping and quantification of animal behavior. Philipsberg PA, Christenson Wick Z, Diego KS, Vaughan N, Galas A, Jurkowski A, Feng Y, Vetere LM, Chen L, Soler I, Cai DJ, Shuman T Neuroscience letters 37619698 Neurosci Lett 2023 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/37619698
Simultaneous dual-color calcium imaging in freely-behaving mice. Dong Z, Feng Y, Diego K, Baggetta AM, Sweis BM, Pennington ZT, Lamsifer SI, Zaki Y, Sangiuliano F, Philipsberg PA, Morales-Rodriguez D, Kircher D, Slesinger P, Shuman T, Aharoni D, Cai DJ bioRxiv : the preprint server for biology 39005306 bioRxiv 2024 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/39005306
India ink to 3D imaging: The legacy of Dr. Deepak "Dee" N. Pandya and his influence on generations of neuroanatomists. Blatt GJ, Brandenburg C, Poulopoulos A The Journal of comparative neurology 37916788 J Comp Neurol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37916788
Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins. Richardson RR, Steyert M, Khim SN, Crutcher GW, Brandenburg C, Robertson CD, Romanowski AJ, Inen J, Altas B, Poulopoulos A The CRISPR journal 37713292 CRISPR J 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37713292
Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos A Biological psychiatry 38154503 Biol Psychiatry 2024 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/38154503
Prime Editing of Mouse Primary Neurons. Robertson CD, Richardson RR, Steyert M, Martin CA, Flynn C, Poulopoulos A Methods in molecular biology (Clifton, N.J.) 40220094 Methods Mol Biol 2025 https://www.ncbi.nlm.nih.gov/pubmed/40220094
NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold. Iffland PH, Everett ME, Cobb-Pitstick KM, Bowser LE, Barnes AE, Babus JK, Romanowski AJ, Baybis M, Elziny S, Puffenberger EG, Gonzaga-Jauregui C, Poulopoulos A, Carson VJ, Crino PB Brain : a journal of neurology 35136953 Brain 2022 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/35136953
Neuronal mTOR Outposts: Implications for Translation, Signaling, and Plasticity. Altas B, Romanowski AJ, Bunce GW, Poulopoulos A Frontiers in cellular neuroscience 35465614 Front Cell Neurosci 2022 https://www.ncbi.nlm.nih.gov/pubmed/35465614
Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres. Poulopoulos A, Davis P, Brandenburg C, Itoh Y, Galazo MJ, Greig LC, Romanowski AJ, Budnik B, Macklis JD bioRxiv : the preprint server for biology 38585721 bioRxiv 2024 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/38585721
Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing. Robertson CD, Davis P, Richardson RR, Iffland PH 2nd, Vieira DCO, Steyert M, McKeon PN, Romanowski AJ, Crutcher G, Jašarević E, Wolff SBE, Mathur BN, Crino PB, Bale TL, Dick IE, Poulopoulos A bioRxiv : the preprint server for biology 38106154 bioRxiv 2023 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/38106154
The brain's dark transcriptome: Sequencing RNA in distal compartments of neurons and glia. Ament SA, Poulopoulos A Current opinion in neurobiology 37196598 Curr Opin Neurobiol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37196598
Neural resources shift under Methylphenidate: A computational approach to examine anxiety-cognition interplay. Saggar M, Bruno J, Gaillard C, Claudino L, Ernst M NeuroImage 36273770 Neuroimage 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36273770
Cross-attractor repertoire provides new perspective on structure-function relationship in the brain. Zhang M, Sun Y, Saggar M NeuroImage 35732244 Neuroimage 2022 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/35732244
Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults. Ayub R, Sun KL, Flores RE, Lam VT, Jo B, Saggar M, Fung LK Translational psychiatry 33536431 Transl Psychiatry 2021 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/33536431
Pushing the Boundaries of Psychiatric Neuroimaging to Ground Diagnosis in Biology. Saggar M, Uddin LQ eNeuro 31685674 eNeuro 2019 Nov/Dec https://www.ncbi.nlm.nih.gov/pubmed/31685674
Deconstructing the Mapper algorithm to extract richer topological and temporal features from functional neuroimaging data. Haşegan D, Geniesse C, Chowdhury S, Saggar M bioRxiv : the preprint server for biology 37904918 bioRxiv 2023 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/37904918
Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial. Gajawelli N, Geoly AD, Batail JM, Xiao X, Maron-Katz A, Cole E, Azeez A, Kratter IH, Saggar M, Williams NR Npj mental health research 38971869 Npj Ment Health Res 2024 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/38971869
Generating dynamical neuroimaging spatiotemporal representations (DyNeuSR) using topological data analysis. Geniesse C, Sporns O, Petri G, Saggar M Network neuroscience (Cambridge, Mass.) 31410378 Netw Neurosci 2019 https://www.ncbi.nlm.nih.gov/pubmed/31410378
Development of top-down cortical propagations in youth. Pines A, Keller AS, Larsen B, Bertolero M, Ashourvan A, Bassett DS, Cieslak M, Covitz S, Fan Y, Feczko E, Houghton A, Rueter AR, Saggar M, Shafiei G, Tapera TM, Vogel J, Weinstein SM, Shinohara RT, Williams LM, Fair DA, Satterthwaite TD Neuron 36803653 Neuron 2023 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/36803653
Altered canonical and striatal-frontal resting state functional connectivity in children with pathogenic variants in the Ras/mitogen-activated protein kinase pathway. Bruno JL, Shrestha SB, Reiss AL, Saggar M, Green T Molecular psychiatry 35087195 Mol Psychiatry 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35087195
Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders. Sun Y, Zhang M, Saggar M NeuroImage 37579998 Neuroimage 2023 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/37579998
NeuMapper: A scalable computational framework for multiscale exploration of the brain's dynamical organization. Geniesse C, Chowdhury S, Saggar M Network neuroscience (Cambridge, Mass.) 35733428 Netw Neurosci 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35733428
Precision dynamical mapping using topological data analysis reveals a hub-like transition state at rest. Saggar M, Shine JM, Liégeois R, Dosenbach NUF, Fair D Nature communications 35970984 Nat Commun 2022 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/35970984
Spontaneous and deliberate modes of creativity: Multitask eigen-connectivity analysis captures latent cognitive modes during creative thinking. Xie H, Beaty RE, Jahanikia S, Geniesse C, Sonalkar NS, Saggar M NeuroImage 34469816 Neuroimage 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34469816
Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice. Rosenberg AM, Saggar M, Monzel AS, Devine J, Rogu P, Limoges A, Junker A, Sandi C, Mosharov EV, Dumitriu D, Anacker C, Picard M Nature communications 37563104 Nat Commun 2023 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/37563104
Brief intensive social gaze training reorganizes functional brain connectivity in boys with fragile X syndrome. Saggar M, Bruno JL, Hall SS Cerebral cortex (New York, N.Y. : 1991) 36376964 Cereb Cortex 2023 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/36376964
Deconstructing the Mapper algorithm to extract richer topological and temporal features from functional neuroimaging data. Haşegan D, Geniesse C, Chowdhury S, Saggar M Network neuroscience (Cambridge, Mass.) 39735492 Netw Neurosci 2024 https://www.ncbi.nlm.nih.gov/pubmed/39735492
Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder. Pasquini L, Fryer SL, Eisendrath SJ, Segal ZV, Lee AJ, Brown JA, Saggar M, Mathalon DH Biological psychiatry. Cognitive neuroscience and neuroimaging 36754677 Biol Psychiatry Cogn Neurosci Neuroimaging 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/36754677
Temporal Mapper: Transition networks in simulated and real neural dynamics. Zhang M, Chowdhury S, Saggar M Network neuroscience (Cambridge, Mass.) 37397880 Netw Neurosci 2023 https://www.ncbi.nlm.nih.gov/pubmed/37397880
Network effects of Stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder: a randomized, controlled trial. Batail JM, Xiao X, Azeez A, Tischler C, Kratter IH, Bishop JH, Saggar M, Williams NR Translational psychiatry 37400432 Transl Psychiatry 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/37400432
Densely sampled stimulus-response map of human cortex with single pulse TMS-EEG and its relation to whole brain neuroimaging measures. Sun Y, Lucas MV, Cline CC, Menezes MC, Kim S, Badami FS, Narayan M, Wu W, Daskalakis ZJ, Etkin A, Saggar M bioRxiv : the preprint server for biology 38948696 bioRxiv 2024 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/38948696
Topological data analysis reveals rigid brain-state dynamics during self-viewing in trait rumination. Geniesse C, Jahanikia S, Xie H, Sonalkar NS, Williams LM, Saggar M bioRxiv : the preprint server for biology 41497618 bioRxiv 2025 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/41497618
Wireless multilateral devices for optogenetic studies of individual and social behaviors. Yang Y, Wu M, Vázquez-Guardado A, Wegener AJ, Grajales-Reyes JG, Deng Y, Wang T, Avila R, Moreno JA, Minkowicz S, Dumrongprechachan V, Lee J, Zhang S, Legaria AA, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson ZR, Gereau RW 4th, Good CH, Xie Z, Huang Y, Kozorovitskiy Y, Rogers JA Nature neuroscience 33972800 Nat Neurosci 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33972800
Emergent intra-pair sex differences and organized behavior in pair bonded prairie voles (Microtus ochrogaster). Brusman LE, Protter DSW, Fultz AC, Paulson MU, Chapel GD, Elges IO, Cameron RT, Beery AK, Donaldson ZR Genes, brain, and behavior 35044090 Genes Brain Behav 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35044090
Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner. Sadino JM, Donaldson ZR Annals of the New York Academy of Sciences 38594916 Ann N Y Acad Sci 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38594916
Exposure to novel females increases fecundity in adult male prairie voles. Hurd JA, Watanabe YL, Toben GJ, Ford AK, Miller CA, Sergott CE, Kelley D, Donaldson ZR, McCullagh EA bioRxiv : the preprint server for biology 39763992 bioRxiv 2024 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/39763992
PhAT: A flexible open-source GUI-driven toolkit for photometry analysis. Murphy KZ, Haile E, McTigue A, Pierce AF, Donaldson ZR bioRxiv : the preprint server for biology 36993180 bioRxiv 2023 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/36993180
Neurobiology and treatment advances for prolonged grief disorder. Donaldson ZR, Shear MK Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 37479860 Neuropsychopharmacology 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37479860
PhAT: A Flexible Open-Source GUI-Driven Toolkit for Photometry Analysis. Murphy KZ, Haile ED, McTigue AD, Pierce AF, Donaldson ZR Current protocols 37184156 Curr Protoc 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37184156
Sex differences in the reward value of familiar mates in prairie voles. Vahaba DM, Halstead ER, Donaldson ZR, Ahern TH, Beery AK Genes, brain, and behavior 35044087 Genes Brain Behav 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35044087
A neuronal signature for monogamous reunion. Scribner JL, Vance EA, Protter DSW, Sheeran WM, Saslow E, Cameron RT, Klein EM, Jimenez JC, Kheirbek MA, Donaldson ZR Proceedings of the National Academy of Sciences of the United States of America 32381740 Proc Natl Acad Sci U S A 2020 May 19 https://www.ncbi.nlm.nih.gov/pubmed/32381740
Exposure to novel females increases fecundity in adult male prairie voles. Hurd JA, Watanabe YL, Toben GJ, Ford AK, Miller CA, Sergott CE, Kelley D, Donaldson ZR, McCullagh EA Hormones and behavior 40627990 Horm Behav 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40627990
How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles. Harbert KJ, Pellegrini M, Gordon KM, Donaldson ZR Hormones and behavior 32910950 Horm Behav 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32910950
Prairie vole pair bonding and plasticity of the social brain. Hiura LC, Donaldson ZR Trends in neurosciences 36369029 Trends Neurosci 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36369029
Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles. Sadino JM, Bradeen XG, Kelly CJ, Brusman LE, Walker DM, Donaldson ZR eLife 36852906 Elife 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/36852906
Nucleus accumbens dopamine release reflects the selective nature of pair bonds. Pierce AF, Protter DSW, Watanabe YL, Chapel GD, Cameron RT, Donaldson ZR Current biology : CB 38218185 Curr Biol 2024 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/38218185
Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment. El-Kalliny MM, Kushner JK, Sheeran WM, Neilly OE, Winther KE, Brusman LE, Kelberman MA, Hoeffer CA, Donaldson ZR Nature communications 41501009 Nat Commun 2026 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/41501009
Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice. Zahler SH, Taylor DE, Wong JY, Adams JM, Feinberg EH eLife 34970968 Elife 2021 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/34970968
Soma-Targeted Imaging of Neural Circuits by Ribosome Tethering. Chen Y, Jang H, Spratt PWE, Kosar S, Taylor DE, Essner RA, Bai L, Leib DE, Kuo TW, Lin YC, Patel M, Subkhangulova A, Kato S, Feinberg EH, Bender KJ, Knight ZA, Garrison JL Neuron 32574560 Neuron 2020 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/32574560
Transcriptional profiling of mouse projection neurons with VECTORseq. Cheung V, Chung P, Feinberg EH STAR protocols 36035788 STAR Protoc 2022 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/36035788
Virally encoded connectivity transgenic overlay RNA sequencing (VECTORseq) defines projection neurons involved in sensorimotor integration. Cheung V, Chung P, Bjorni M, Shvareva VA, Lopez YC, Feinberg EH Cell reports 34936877 Cell Rep 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34936877
Hindbrain modules differentially transform activity of single collicular neurons to coordinate movements. Zahler SH, Taylor DE, Wright BS, Wong JY, Shvareva VA, Park YA, Feinberg EH Cell 37343561 Cell 2023 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/37343561
An open-source transparent microelectrode array. Weaver IA, Li AW, Shields BC, Tadross MR Journal of neural engineering 35349992 J Neural Eng 2022 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/35349992
Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell. Manz KM, Coleman BC, Grueter CA, Shields BC, Tadross MR, Grueter BA The Journal of neuroscience : the official journal of the Society for Neuroscience 33737458 J Neurosci 2021 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/33737458
Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations. Fleming EA, Field GD, Tadross MR, Hull C Nature neuroscience 38321293 Nat Neurosci 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38321293
Acute restraint stress redirects prefrontal cortex circuit function through mGlu(5) receptor plasticity on somatostatin-expressing interneurons. Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ Neuron 35045338 Neuron 2022 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/35045338
Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity. Cammarata CM, Pei Y, Hu T, Shields BC, Lim SSX, Hawley T, Li JY, St Amand D, Brunel N, Tadross MR, Glickfeld LL Cell reports 40638386 Cell Rep 2025 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/40638386
Natural phasic inhibition of dopamine neurons signals cognitive rigidity. Burwell SCV, Yan H, Lim SSX, Shields BC, Tadross MR bioRxiv : the preprint server for biology 38766037 bioRxiv 2024 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/38766037
DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity. Shields BC, Yan H, Lim SSX, Burwell SCV, Cammarata CM, Fleming EA, Yousefzadeh SA, Goldenshtein VZ, Kahuno EW, Vagadia PP, Loughran MH, Zhiquan L, McDonnell ME, Scalabrino ML, Thapa M, Hawley TM, Field GD, Hull C, Schiltz GE, Glickfeld LL, Reitz AB, Tadross MR Nature methods 38877316 Nat Methods 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38877316
Diverse Molecular Mechanisms Contribute to Differential Expression of Human Duplicated Genes. Shew CJ, Carmona-Mora P, Soto DC, Mastoras M, Roberts E, Rosas J, Jagannathan D, Kaya G, O'Geen H, Dennis MY Molecular biology and evolution 34009325 Mol Biol Evol 2021 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/34009325
RapID Cell Counter: Semi-Automated and Mid-Throughput Estimation of Cell Density within Diverse Cortical Layers. Sekar A, Sanches TM, Hino K, Kumar M, Wang J, Ha E, Durbin-Johnson B, Simó S, Dennis MY eNeuro 34725102 eNeuro 2021 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/34725102
Local genetic adaptation to habitat in wild chimpanzees. Ostridge HJ, Fontsere C, Lizano E, Soto DC, Schmidt JM, Saxena V, Alvarez-Estape M, Barratt CD, Gratton P, Bocksberger G, Lester JD, Dieguez P, Agbor A, Angedakin S, Assumang AK, Bailey E, Barubiyo D, Bessone M, Brazzola G, Chancellor R, Cohen H, Coupland C, Danquah E, Deschner T, Dotras L, Dupain J, Egbe VE, Granjon AC, Head J, Hedwig D, Hermans V, Hernandez-Aguilar RA, Jeffery KJ, Jones S, Junker J, Kadam P, Kaiser M, Kalan AK, Kambere M, Kienast I, Kujirakwinja D, Langergraber KE, Lapuente J, Larson B, Laudisoit A, Lee KC, Llana M, Maretti G, Martín R, Meier AC, Morgan D, Neil E, Nicholl S, Nixon S, Normand E, Orbell C, Ormsby LJ, Orume R, Pacheco L, Preece J, Regnaut S, Robbins MM, Rundus A, Sanz C, Sciaky L, Sommer V, Stewart FA, Tagg N, Tédonzong LR, van Schijndel J, Vendras E, Wessling EG, Willie J, Wittig RM, Yuh YG, Yurkiw K, Vigilant L, Piel AK, Boesch C, Kühl HS, Dennis MY, Marques-Bonet T, Arandjelovic M, Andrés AM Science (New York, N.Y.) 41296989 Science 2025 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/41296989
m(6)A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly. Nishizaki SS, Haghani NK, La GN, Mariano NAF, Uribe-Salazar JM, Kaya G, Regester M, Andrews DS, Nordahl CW, Amaral DG, Dennis MY Autism research : official journal of the International Society for Autism Research 39887636 Autism Res 2025 May https://www.ncbi.nlm.nih.gov/pubmed/39887636
Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing. Soto DC, Shew C, Mastoras M, Schmidt JM, Sahasrabudhe R, Kaya G, Andrés AM, Dennis MY Genes 32143403 Genes (Basel) 2020 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/32143403
FixItFelix: improving genomic analysis by fixing reference errors. Behera S, LeFaive J, Orchard P, Mahmoud M, Paulin LF, Farek J, Soto DC, Parker SCJ, Smith AV, Dennis MY, Zook JM, Sedlazeck FJ Genome biology 36810122 Genome Biol 2023 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/36810122
Evaluation of CRISPR gene-editing tools in zebrafish. Uribe-Salazar JM, Kaya G, Sekar A, Weyenberg K, Ingamells C, Dennis MY BMC genomics 34986794 BMC Genomics 2022 Jan 6 https://www.ncbi.nlm.nih.gov/pubmed/34986794
Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism. Zhu Y, Gomez JA, Laufer BI, Mordaunt CE, Mouat JS, Soto DC, Dennis MY, Benke KS, Bakulski KM, Dou J, Marathe R, Jianu JM, Williams LA, Gutierrez Fugón OJ, Walker CK, Ozonoff S, Daniels J, Grosvenor LP, Volk HE, Feinberg JI, Fallin MD, Hertz-Picciotto I, Schmidt RJ, Yasui DH, LaSalle JM Genome biology 35168652 Genome Biol 2022 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/35168652
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Telomere-to-telomere assembly of a complete human X chromosome. Miga KH, Koren S, Rhie A, Vollger MR, Gershman A, Bzikadze A, Brooks S, Howe E, Porubsky D, Logsdon GA, Schneider VA, Potapova T, Wood J, Chow W, Armstrong J, Fredrickson J, Pak E, Tigyi K, Kremitzki M, Markovic C, Maduro V, Dutra A, Bouffard GG, Chang AM, Hansen NF, Wilfert AB, Thibaud-Nissen F, Schmitt AD, Belton JM, Selvaraj S, Dennis MY, Soto DC, Sahasrabudhe R, Kaya G, Quick J, Loman NJ, Holmes N, Loose M, Surti U, Risques RA, Graves Lindsay TA, Fulton R, Hall I, Paten B, Howe K, Timp W, Young A, Mullikin JC, Pevzner PA, Gerton JL, Sullivan BA, Eichler EE, Phillippy AM Nature 32663838 Nature 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32663838
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Serotonin neurons in mating female mice are activated by male ejaculation. Troconis EL, Seo C, Guru A, Warden MR bioRxiv : the preprint server for biology 37645786 bioRxiv 2023 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/37645786
Depression: the search for separable behaviors and circuits. Post RJ, Warden MR Current opinion in neurobiology 29529482 Curr Opin Neurobiol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29529482
Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode. Seo C, Guru A, Jin M, Ito B, Sleezer BJ, Ho YY, Wang E, Boada C, Krupa NA, Kullakanda DS, Shen CX, Warden MR Science (New York, N.Y.) 30705194 Science 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30705194
Infralimbic parvalbumin neural activity facilitates cued threat avoidance. Ho YY, Yang Q, Boddu P, Bulkin DA, Warden MR bioRxiv : the preprint server for biology 37645876 bioRxiv 2024 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/37645876
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Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model. Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L Cell reports 29996097 Cell Rep 2018 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/29996097
Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. Patriarchi T, Shen A, He W, Baikoghli M, Cheng RH, Xiang YK, Coleman MA, Tian L Scientific reports 29476125 Sci Rep 2018 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/29476125
Psychedelic-inspired drug discovery using an engineered biosensor. Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L Cell 33915107 Cell 2021 May 13 https://www.ncbi.nlm.nih.gov/pubmed/33915107
Imaging voltage and brain chemistry with genetically encoded sensors and modulators. Pal A, Tian L Current opinion in chemical biology 32823064 Curr Opin Chem Biol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32823064
An expanded palette of dopamine sensors for multiplex imaging in vivo. Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L Nature methods 32895537 Nat Methods 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32895537
Maps of neuronal activity across the mouse brain. Andreoni A, Tian L Nature biomedical engineering 31073176 Nat Biomed Eng 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31073176
SynQuant: an automatic tool to quantify synapses from microscopy images. Wang Y, Wang C, Ranefall P, Broussard GJ, Wang Y, Shi G, Lyu B, Wu CT, Wang Y, Tian L, Yu G Bioinformatics (Oxford, England) 31596456 Bioinformatics 2020 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/31596456
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum. Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA Frontiers in cellular neuroscience 31798415 Front Cell Neurosci 2019 https://www.ncbi.nlm.nih.gov/pubmed/31798415
A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System. de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S Neuron 30503173 Neuron 2019 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/30503173
Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor. Salinas AG, Lee JO, Augustin SM, Zhang S, Patriarchi T, Tian L, Morales M, Mateo Y, Lovinger DM Nature communications 37739964 Nat Commun 2023 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/37739964
Monitoring activity in neural circuits with genetically encoded indicators. Broussard GJ, Liang R, Tian L Frontiers in molecular neuroscience 25538558 Front Mol Neurosci 2014 https://www.ncbi.nlm.nih.gov/pubmed/25538558
Imaging Neurotransmitter and Neuromodulator Dynamics In Vivo with Genetically Encoded Indicators. Sabatini BL, Tian L Neuron 33058762 Neuron 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/33058762
Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. Corre J, van Zessen R, Loureiro M, Patriarchi T, Tian L, Pascoli V, Lüscher C eLife 30373717 Elife 2018 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/30373717
In vivo measurement of afferent activity with axon-specific calcium imaging. Broussard GJ, Liang Y, Fridman M, Unger EK, Meng G, Xiao X, Ji N, Petreanu L, Tian L Nature neuroscience 30127424 Nat Neurosci 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30127424
Imaging chemical neurotransmission with genetically encoded fluorescent sensors. Liang R, Broussard GJ, Tian L ACS chemical neuroscience 25565280 ACS Chem Neurosci 2015 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/25565280
Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance. Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tsuboi T, Kitaguchi T, Tian L, McHugh TJ, Hirase H Nature communications 31980655 Nat Commun 2020 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/31980655
Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1. Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V eLife 31545171 Elife 2019 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/31545171
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J Nature chemical biology 32989297 Nat Chem Biol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32989297
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L Cell 33333022 Cell 2020 Dec 23 https://www.ncbi.nlm.nih.gov/pubmed/33333022
H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification. Nicetto D, Donahue G, Jain T, Peng T, Sidoli S, Sheng L, Montavon T, Becker JS, Grindheim JM, Blahnik K, Garcia BA, Tan K, Bonasio R, Jenuwein T, Zaret KS Science (New York, N.Y.) 30606806 Science 2019 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/30606806
Social reprogramming in ants induces longevity-associated glia remodeling. Sheng L, Shields EJ, Gospocic J, Glastad KM, Ratchasanmuang P, Berger SL, Raj A, Little S, Bonasio R Science advances 32875108 Sci Adv 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32875108
An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants. Yan H, Opachaloemphan C, Mancini G, Yang H, Gallitto M, Mlejnek J, Leibholz A, Haight K, Ghaninia M, Huo L, Perry M, Slone J, Zhou X, Traficante M, Penick CA, Dolezal K, Gokhale K, Stevens K, Fetter-Pruneda I, Bonasio R, Zwiebel LJ, Berger SL, Liebig J, Reinberg D, Desplan C Cell 28802043 Cell 2017 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/28802043
The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants. Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS, Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R Cell 28802044 Cell 2017 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/28802044
Specialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones. Pask GM, Slone JD, Millar JG, Das P, Moreira JA, Zhou X, Bello J, Berger SL, Bonasio R, Desplan C, Reinberg D, Liebig J, Zwiebel LJ, Ray A Nature communications 28819196 Nat Commun 2017 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/28819196
The expanding epigenetic landscape of non-model organisms. Bonasio R The Journal of experimental biology 25568458 J Exp Biol 2015 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/25568458
Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency. Beck DB, Petracovici A, He C, Moore HW, Louie RJ, Ansar M, Douzgou S, Sithambaram S, Cottrell T, Santos-Cortez RLP, Prijoles EJ, Bend R, Keren B, Mignot C, Nougues MC, Õunap K, Reimand T, Pajusalu S, Zahid M, Saqib MAN, Buratti J, Seaby EG, McWalter K, Telegrafi A, Baldridge D, Shinawi M, Leal SM, Schaefer GB, Stevenson RE, Banka S, Bonasio R, Fahrner JA American journal of human genetics 31928709 Am J Hum Genet 2020 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/31928709
lncRedibly versatile: biochemical and biological functions of long noncoding RNAs. Shields EJ, Petracovici AF, Bonasio R The Biochemical journal 30971458 Biochem J 2019 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/30971458
Kr-h1 maintains distinct caste-specific neurotranscriptomes in response to socially regulated hormones. Gospocic J, Glastad KM, Sheng L, Shields EJ, Berger SL, Bonasio R Cell 34739833 Cell 2021 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/34739833
Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus. Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, Berger SL Science (New York, N.Y.) 26722000 Science 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26722000
RNA Binding to CBP Stimulates Histone Acetylation and Transcription. Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL Cell 28086087 Cell 2017 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/28086087
Genome annotation with long RNA reads reveals new patterns of gene expression and improves single-cell analyses in an ant brain. Shields EJ, Sorida M, Sheng L, Sieriebriennikov B, Ding L, Bonasio R BMC biology 34838024 BMC Biol 2021 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/34838024
High-Quality Genome Assemblies Reveal Long Non-coding RNAs Expressed in Ant Brains. Shields EJ, Sheng L, Weiner AK, Garcia BA, Bonasio R Cell reports 29874592 Cell Rep 2018 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/29874592
Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L Nature cell biology 29695787 Nat Cell Biol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29695787
CA1 hippocampal network activity changes during sleep-dependent memory consolidation. Ognjanovski N, Maruyama D, Lashner N, Zochowski M, Aton SJ Frontiers in systems neuroscience 24860440 Front Syst Neurosci 2014 https://www.ncbi.nlm.nih.gov/pubmed/24860440
Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation. Ognjanovski N, Schaeffer S, Wu J, Mofakham S, Maruyama D, Zochowski M, Aton SJ Nature communications 28382952 Nat Commun 2017 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/28382952
The role of clock genes in sleep, stress and memory. Bolsius YG, Zurbriggen MD, Kim JK, Kas MJ, Meerlo P, Aton SJ, Havekes R Biochemical pharmacology 33647263 Biochem Pharmacol 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33647263
Acetylcholine-gated current translates wake neuronal firing rate information into a spike timing-based code in Non-REM sleep, stabilizing neural network dynamics during memory consolidation. Skilling QM, Eniwaye B, Clawson BC, Shaver J, Ognjanovski N, Aton SJ, Zochowski M PLoS computational biology 34543284 PLoS Comput Biol 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34543284
Set and setting: how behavioral state regulates sensory function and plasticity. Aton SJ Neurobiology of learning and memory 23792020 Neurobiol Learn Mem 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/23792020
Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation. Yang Y, Gritton H, Sarter M, Aton SJ, Booth V, Zochowski M PLoS computational biology 34329297 PLoS Comput Biol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34329297
Sleep Promotes, and Sleep Loss Inhibits, Selective Changes in Firing Rate, Response Properties and Functional Connectivity of Primary Visual Cortex Neurons. Clawson BC, Durkin J, Suresh AK, Pickup EJ, Broussard CG, Aton SJ Frontiers in systems neuroscience 30245617 Front Syst Neurosci 2018 https://www.ncbi.nlm.nih.gov/pubmed/30245617
Hippocampal Network Oscillations Rescue Memory Consolidation Deficits Caused by Sleep Loss. Ognjanovski N, Broussard C, Zochowski M, Aton SJ Cerebral cortex (New York, N.Y. : 1991) 30060138 Cereb Cortex 2018 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/30060138
Linking Network Activity to Synaptic Plasticity during Sleep: Hypotheses and Recent Data. Puentes-Mestril C, Aton SJ Frontiers in neural circuits 28932187 Front Neural Circuits 2017 https://www.ncbi.nlm.nih.gov/pubmed/28932187
Sleep loss disrupts Arc expression in dentate gyrus neurons. Delorme JE, Kodoth V, Aton SJ Neurobiology of learning and memory 29635031 Neurobiol Learn Mem 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/29635031
Hypnotic treatment reverses NREM sleep disruption and EEG desynchronization in a mouse model of Fragile X syndrome to rescue memory consolidation deficits. Martinez JD, Wilson LG, Brancaleone WP, Peterson KG, Popke DS, Garzon VC, Perez Tremble RE, Donnelly MJ, Mendez Ortega SL, Torres D, Shaver JJ, Clawson BC, Jiang S, Yang Z, Aton SJ bioRxiv : the preprint server for biology 37502832 bioRxiv 2023 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/37502832
Form and Function of Sleep Spindles across the Lifespan. Clawson BC, Durkin J, Aton SJ Neural plasticity 27190654 Neural Plast 2016 https://www.ncbi.nlm.nih.gov/pubmed/27190654
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T eLife 27549340 Elife 2016 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/27549340
Waking up to the alarm: sleep, clocks, and making memory (s)tick. Gerstner JR, Aton SJ, Heller HC Frontiers in systems neuroscience 25954165 Front Syst Neurosci 2015 https://www.ncbi.nlm.nih.gov/pubmed/25954165
Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory. Prince TM, Wimmer M, Choi J, Havekes R, Aton S, Abel T Neurobiology of learning and memory 24380868 Neurobiol Learn Mem 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24380868
Hippocampal neurons' cytosolic and membrane-bound ribosomal transcript profiles are differentially regulated by learning and subsequent sleep. Delorme J, Wang L, Kodoth V, Wang Y, Ma J, Jiang S, Aton SJ Proceedings of the National Academy of Sciences of the United States of America 34819370 Proc Natl Acad Sci U S A 2021 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/34819370
Sleep Loss Drives Brain Region-Specific and Cell Type-Specific Alterations in Ribosome-Associated Transcripts Involved in Synaptic Plasticity and Cellular Timekeeping. Puentes-Mestril C, Delorme J, Wang L, Donnelly M, Popke D, Jiang S, Aton SJ The Journal of neuroscience : the official journal of the Society for Neuroscience 34001629 J Neurosci 2021 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/34001629
Functional network stability and average minimal distance - A framework to rapidly assess dynamics of functional network representations. Wu J, Skilling QM, Maruyama D, Li C, Ognjanovski N, Aton S, Zochowski M Journal of neuroscience methods 29294309 J Neurosci Methods 2018 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/29294309
Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks. Roach JP, Pidde A, Katz E, Wu J, Ognjanovski N, Aton SJ, Zochowski MR Proceedings of the National Academy of Sciences of the United States of America 29545273 Proc Natl Acad Sci U S A 2018 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/29545273
Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome. Martinez JD, Wilson LG, Brancaleone WP, Peterson KG, Popke DS, Garzon VC, Perez Tremble RE, Donnelly MJ, Mendez Ortega SL, Torres D, Shaver JJ, Jiang S, Yang Z, Aton SJ Cell reports 38787724 Cell Rep 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38787724
Erratum: Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation. Ognjanovski N, Schaeffer S, Wu J, Mofakham S, Maruyama D, Zochowski M, Aton SJ Nature communications 28681846 Nat Commun 2017 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/28681846
Editorial-Methods and models in sleep research. Aton SJ, Di Giovanni G, Leresche N Journal of neuroscience methods 30576680 J Neurosci Methods 2019 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/30576680
Sleep loss drives acetylcholine- and somatostatin interneuron-mediated gating of hippocampal activity to inhibit memory consolidation. Delorme J, Wang L, Kuhn FR, Kodoth V, Ma J, Martinez JD, Raven F, Toth BA, Balendran V, Vega Medina A, Jiang S, Aton SJ Proceedings of the National Academy of Sciences of the United States of America 34344824 Proc Natl Acad Sci U S A 2021 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/34344824
Digital Phenotyping to Quantify Psychosocial Well-Being Trajectories After Spinal Cord Injury. Mercier HW, Hamner JW, Torous J, Onnela JP, Taylor JA American journal of physical medicine & rehabilitation 32576743 Am J Phys Med Rehabil 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32576743
EndNote: Feature-based classification of networks. Barnett I, Malik N, Kuijjer ML, Mucha PJ, Onnela JP Network science (Cambridge University Press) 31984135 Netw Sci (Camb Univ Press) 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31984135
Harnessing Smartphone-Based Digital Phenotyping to Enhance Behavioral and Mental Health. Onnela JP, Rauch SL Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 26818126 Neuropsychopharmacology 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26818126
New Tools for New Research in Psychiatry: A Scalable and Customizable Platform to Empower Data Driven Smartphone Research. Torous J, Kiang MV, Lorme J, Onnela JP JMIR mental health 27150677 JMIR Ment Health 2016 May 5 https://www.ncbi.nlm.nih.gov/pubmed/27150677
Beyond smartphones and sensors: choosing appropriate statistical methods for the analysis of longitudinal data. Barnett I, Torous J, Staples P, Keshavan M, Onnela JP Journal of the American Medical Informatics Association : JAMIA 30272176 J Am Med Inform Assoc 2018 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/30272176
Expected Versus Experienced Health-Related Quality of Life Among Patients Recovering From Cancer Surgery: A Prospective Cohort Study. Panda N, Solsky I, Neal BJ, Hawrusik B, Lipsitz S, Lubitz CC, Gibbons C, Brindle M, Sinyard RD, Onnela JP, Cauley CE, Haynes AB Annals of surgery open : perspectives of surgical history, education, and clinical approaches 34179891 Ann Surg Open 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34179891
Smartphone-based Assessment of Preoperative Decision Conflict and Postoperative Physical Activity Among Patients Undergoing Cancer Surgery: A Prospective Cohort Study. Panda N, Solsky I, Cauley CE, Lipsitz S, Desai EV, Huang EJ, Benjamin EM, Lubitz CC, Onnela JP, Haynes AB Annals of surgery 32941270 Ann Surg 2022 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/32941270
Augmented Movelet Method for Activity Classification Using Smartphone Gyroscope and Accelerometer Data. Huang EJ, Onnela JP Sensors (Basel, Switzerland) 32630752 Sensors (Basel) 2020 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/32630752
Fluctuations in behavior and affect in college students measured using deep phenotyping. Vidal Bustamante CM, Coombs G 3rd, Rahimi-Eichi H, Mair P, Onnela JP, Baker JT, Buckner RL Scientific reports 35121741 Sci Rep 2022 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/35121741
The HOPE Pilot Study: Harnessing Patient-Reported Outcomes and Biometric Data to Enhance Cancer Care. Wright AA, Raman N, Staples P, Schonholz S, Cronin A, Carlson K, Keating NL, Onnela JP JCO clinical cancer informatics 30652585 JCO Clin Cancer Inform 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30652585
The relationship of rate and pause features to the communicative participation of people living with ALS. Connaghan KP, Green JR, Eshghi M, Haenssler AE, Scheier ZA, Clark A, Iyer A, Richburg BD, Rowe HP, Okada J, Johnson SA, Onnela JP, Burke KM, Berry JD Muscle & nerve 38837773 Muscle Nerve 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38837773
Sociodemographic characteristics of missing data in digital phenotyping. Kiang MV, Chen JT, Krieger N, Buckee CO, Alexander MJ, Baker JT, Buckner RL, Coombs G 3rd, Rich-Edwards JW, Carlson KW, Onnela JP Scientific reports 34326370 Sci Rep 2021 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/34326370
Smartphone Global Positioning System (GPS) Data Enhances Recovery Assessment After Breast Cancer Surgery. Panda N, Solsky I, Hawrusik B, Liu G, Reeder H, Lipsitz S, Desai EV, Lowery KW, Miller K, Gadd MA, Lubitz CC, Smith BL, Specht M, Onnela JP, Haynes AB Annals of surgical oncology 32812109 Ann Surg Oncol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/32812109
Relapse prediction in schizophrenia through digital phenotyping: a pilot study. Barnett I, Torous J, Staples P, Sandoval L, Keshavan M, Onnela JP Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 29511333 Neuropsychopharmacology 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29511333
Understanding the quality, effectiveness and attributes of top-rated smartphone health apps. Wisniewski H, Liu G, Henson P, Vaidyam A, Hajratalli NK, Onnela JP, Torous J Evidence-based mental health 30635262 Evid Based Ment Health 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30635262
Smartphone-Based Tracking of Sleep in Depression, Anxiety, and Psychotic Disorders. Aledavood T, Torous J, Triana Hoyos AM, Naslund JA, Onnela JP, Keshavan M Current psychiatry reports 31161412 Curr Psychiatry Rep 2019 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/31161412
Open-source Longitudinal Sleep Analysis From Accelerometer Data (DPSleep): Algorithm Development and Validation. Rahimi-Eichi H, Coombs Iii G, Vidal Bustamante CM, Onnela JP, Baker JT, Buckner RL JMIR mHealth and uHealth 34612831 JMIR Mhealth Uhealth 2021 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/34612831
Utilizing a Personal Smartphone Custom App to Assess the Patient Health Questionnaire-9 (PHQ-9) Depressive Symptoms in Patients With Major Depressive Disorder. Torous J, Staples P, Shanahan M, Lin C, Peck P, Keshavan M, Onnela JP JMIR mental health 26543914 JMIR Ment Health 2015 Jan-Mar https://www.ncbi.nlm.nih.gov/pubmed/26543914
Realizing the potential of mobile mental health: new methods for new data in psychiatry. Torous J, Staples P, Onnela JP Current psychiatry reports 26073363 Curr Psychiatry Rep 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26073363
Estimating longitudinal depressive symptoms from smartphone data in a transdiagnostic cohort. Pellegrini AM, Huang EJ, Staples PC, Hart KL, Lorme JM, Brown HE, Perlis RH, Onnela JJ Brain and behavior 35076166 Brain Behav 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35076166
Determining sample size and length of follow-up for smartphone-based digital phenotyping studies. Barnett I, Torous J, Reeder HT, Baker J, Onnela JP Journal of the American Medical Informatics Association : JAMIA 33043370 J Am Med Inform Assoc 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33043370
Design and results of a smartphone-based digital phenotyping study to quantify ALS progression. Berry JD, Paganoni S, Carlson K, Burke K, Weber H, Staples P, Salinas J, Chan J, Green JR, Connaghan K, Barback J, Onnela JP Annals of clinical and translational neurology 31139685 Ann Clin Transl Neurol 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31139685
Characterizing the clinical relevance of digital phenotyping data quality with applications to a cohort with schizophrenia. Torous J, Staples P, Barnett I, Sandoval LR, Keshavan M, Onnela JP NPJ digital medicine 31304300 NPJ Digit Med 2018 https://www.ncbi.nlm.nih.gov/pubmed/31304300
A crossroad for validating digital tools in schizophrenia and mental health. Torous J, Staples P, Barnett I, Onnela JP, Keshavan M NPJ schizophrenia 29626190 NPJ Schizophr 2018 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/29626190
A comparison of passive and active estimates of sleep in a cohort with schizophrenia. Staples P, Torous J, Barnett I, Carlson K, Sandoval L, Keshavan M, Onnela JP NPJ schizophrenia 29038553 NPJ Schizophr 2017 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/29038553
Precision Assessment of Real-World Associations Between Stress and Sleep Duration Using Actigraphy Data Collected Continuously for an Academic Year: Individual-Level Modeling Study. Vidal Bustamante CM, Coombs Iii G, Rahimi-Eichi H, Mair P, Onnela JP, Baker JT, Buckner RL JMIR formative research 38687600 JMIR Form Res 2024 Apr 30 https://www.ncbi.nlm.nih.gov/pubmed/38687600
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Mapping local hot spots with routine tuberculosis data: A pragmatic approach to identify spatial variability. Brooks MB, Millones AK, Puma D, Contreras C, Jimenez J, Tzelios C, Jenkins HE, Yuen CM, Keshavjee S, Lecca L, Becerra MC PloS one 35324987 PLoS One 2022 https://www.ncbi.nlm.nih.gov/pubmed/35324987
Person-centered strategies for delivering TB diagnostic services in Lima, Peru. Yuen CM, Millones AK, Acosta D, Torres I, Farroñay S, Jimenez J, Lecca L Public health action 37736576 Public Health Action 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37736576
Adapting a mobile TB screening unit to provide integrated screening services and linkage to primary care. Millones AK, Cohen S, Acosta D, Campos H, Condeso A, Farroñay S, Torres I, Vargas C, Abanto K, Contreras C, Palomino S, Jimenez J, Lecca L, Yuen CM Public health action 39618835 Public Health Action 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39618835
Identifying barriers and facilitators to implementation of community-based tuberculosis active case finding with mobile X-ray units in Lima, Peru: a RE-AIM evaluation. Yuen CM, Puma D, Millones AK, Galea JT, Tzelios C, Calderon RI, Brooks MB, Jimenez J, Contreras C, Nichols TC, Nicholson T, Lecca L, Becerra MC, Keshavjee S BMJ open 34234000 BMJ Open 2021 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/34234000
The impact of the COVID-19 pandemic on patients' experiences obtaining a tuberculosis diagnosis in Peru: a mixed-methods study. Millones AK, Lecca L, Acosta D, Campos H, Del Águila-Rojas E, Farroñay S, Morales G, Ramirez-Sandoval J, Torres I, Jimenez J, Yuen CM BMC infectious diseases 36352374 BMC Infect Dis 2022 Nov 9 https://www.ncbi.nlm.nih.gov/pubmed/36352374
Exploring the Role of the Private Sector in Tuberculosis Detection and Management in Lima, Peru: A Mixed-Methods Patient Pathway Analysis. Wippel C, Farroñay S, Gilbert HN, Millones AK, Acosta D, Torres I, Jimenez J, Alarcón VA, Lecca L, Yuen CM The American journal of tropical medicine and hygiene 38744270 Am J Trop Med Hyg 2024 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/38744270
Barriers and facilitators to tuberculosis diagnosis in Lima, Peru: a mixed methods study. Geadas C, Millones AK, Acosta D, Campos H, Del Aguila-Rojas E, Farroñay S, Morales G, Ramirez-Sandoval J, Torres I, Jimenez J, Lecca L, Yuen CM BMC infectious diseases 39118040 BMC Infect Dis 2024 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/39118040
A role for community-level socioeconomic indicators in targeting tuberculosis screening interventions. Brooks MB, Jenkins HE, Puma D, Tzelios C, Millones AK, Jimenez J, Galea JT, Lecca L, Becerra MC, Keshavjee S, Yuen CM Scientific reports 35039612 Sci Rep 2022 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/35039612
Geospatial analysis of reported activity locations to identify sites for tuberculosis screening. Yuen CM, Brooks MB, Millones AK, Acosta D, Del Águila-Rojas E, Campos H, Farroñay S, Morales G, Ramirez-Sandoval J, Nichols TC, Jimenez J, Jenkins HE, Lecca L Scientific reports 35982104 Sci Rep 2022 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/35982104
Exploring the role of the private sector in tuberculosis detection and management in Lima, Peru: a mixed-methods patient pathway analysis. Wippel C, Farroñay S, Gilbert HN, Millones AK, Acosta D, Torres I, Jimenez J, Lecca L, Yuen CM medRxiv : the preprint server for health sciences 37808756 medRxiv 2023 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/37808756
Closing delivery gaps in the treatment of tuberculosis infection: Lessons from implementation research in Peru. Yuen CM, Millones AK, Puma D, Jimenez J, Galea JT, Calderon R, Pages GS, Brooks MB, Lecca L, Nicholson T, Becerra MC, Keshavjee S PloS one 33606824 PLoS One 2021 https://www.ncbi.nlm.nih.gov/pubmed/33606824
Impact of the private sector on spatial accessibility to chest radiography services in Lima, Peru. Xiong Y, Millones AK, Farroñay S, Torres I, Acosta D, Jordan DR, Jimenez J, Wippel C, Jenkins HE, Lecca L, Yuen CM IJTLD open 38698907 IJTLD Open 2024 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/38698907
Utility of Mycobacterium tuberculosis Genome Sequencing Snapshots to Assess Transmission Dynamics Over Time. Yuen CM, Huang CC, Millones AK, Calderon RI, Manson AL, Jimenez J, Contreras C, Earl AM, Becerra MC, Lecca L, Murray MB The Journal of infectious diseases 37995298 J Infect Dis 2024 May 15 https://www.ncbi.nlm.nih.gov/pubmed/37995298
The Profundity of the Everyday: Family Routines in Adolescence Predict Development in Young Adulthood. Barton AW, Brody GH, Yu T, Kogan SM, Chen E, Ehrlich KB The Journal of adolescent health : official publication of the Society for Adolescent Medicine 30392861 J Adolesc Health 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30392861
Neighborhood poverty, allostatic load, and changes in cellular aging in African American young adults: the moderating role of attachment. Ehrlich KB, Yu T, Sadiq A, Brody GH Attachment & human development 34617499 Attach Hum Dev 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/34617499
Attachment and physical health: introduction to the special issue. B Ehrlich K, Cassidy J Attachment & human development 30406722 Attach Hum Dev 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30406722
The benefits of nurturant-involved parenting for children's internalizing symptoms and cardiometabolic health in high-risk contexts. Wiggins ER, Brisson JM, Lavner JA, Ehrlich KB Development and psychopathology 37386849 Dev Psychopathol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37386849
Socioeconomic disadvantage and high-effort coping in childhood: evidence of skin-deep resilience. Ehrlich KB, Lyle SM, Corallo KL, Brisson JM, Wiggins ER, Yu T, Chen E, Miller GE, Brody GH Journal of child psychology and psychiatry, and allied disciplines 37246563 J Child Psychol Psychiatry 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/37246563
Changes in depressive symptoms and antibody production following influenza vaccination in adolescents and adults. Ehrlich KB, Lyle SM, Corallo KL, Lavner JA, Ross TM Vaccine 38702230 Vaccine 2024 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/38702230
A preliminary investigation of attachment style and inflammation in African-American young adults. Ehrlich KB, Stern JA, Eccles J, Dinh JV, Hopper EA, Kemeny ME, Adam EK, Cassidy J Attachment & human development 30406721 Attach Hum Dev 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30406721
The protective role of parental vigilance in the link between risky childhood environments and health. Corallo KL, Carr CP, Lavner JA, Koss KJ, Ehrlich KB Social science & medicine (1982) 36527897 Soc Sci Med 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36527897
Exposure to parental depression in adolescence and proinflammatory phenotypes 20 years later. Ehrlich KB, Celia-Sanchez ML, Yu T, Heard-Garris N, Chen E, Miller GE, Brody GH Brain, behavior, and immunity 38242368 Brain Behav Immun 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38242368
Maltreatment exposure across childhood and low-grade inflammation: Considerations of exposure type, timing, and sex differences. Ehrlich KB, Miller GE, Rogosch FA, Cicchetti D Developmental psychobiology 32896910 Dev Psychobiol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/32896910
Harsh parenting and youth systemic inflammation: Modulation by the autonomic nervous system. Oshri A, Duprey EB, Liu S, Ehrlich KB Health psychology : official journal of the Division of Health Psychology, American Psychological Association 32202827 Health Psychol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32202827
Attachment and psychoneuroimmunology. Ehrlich KB Current opinion in psychology 29631123 Curr Opin Psychol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/29631123
Preventive parenting intervention during childhood and young black adults' unhealthful behaviors: a randomized controlled trial. Brody GH, Yu T, Miller GE, Ehrlich KB, Chen E Journal of child psychology and psychiatry, and allied disciplines 30203840 J Child Psychol Psychiatry 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30203840
Beyond Early Adversity: The Role of Parenting in Infant Physical Health. Stern JA, Beijers R, Ehrlich KB, Cassidy J, de Weerth C Journal of developmental and behavioral pediatrics : JDBP 32271266 J Dev Behav Pediatr 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32271266
How does the social world shape health across the lifespan? Insights and new directions. Ehrlich KB The American psychologist 33382288 Am Psychol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33382288
Recalled Neighborhood Environments, Parental Control, and Cytokine-Mediated Response to Viral Challenge. Corallo KL, Lyle SM, Murphy MLM, vanDellen MR, Ehrlich KB Psychosomatic medicine 34334728 Psychosom Med 2021 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/34334728
Emotional Distress, Targeted Rejection, and Antibody Production After Influenza Vaccination in Adolescence. Corallo KL, Lyle SM, Carlock MA, Ross TM, Ehrlich KB Psychosomatic medicine 35100185 Psychosom Med 2022 May 1 https://www.ncbi.nlm.nih.gov/pubmed/35100185
Intersections of machine learning and epidemiological methods for health services research. Rose S International journal of epidemiology 32236476 Int J Epidemiol 2021 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/32236476
Ethical Machine Learning in Healthcare. Chen IY, Pierson E, Rose S, Joshi S, Ferryman K, Ghassemi M Annual review of biomedical data science 34396058 Annu Rev Biomed Data Sci 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34396058
All Models are Wrong, but Many are Useful: Learning a Variable's Importance by Studying an Entire Class of Prediction Models Simultaneously. Fisher A, Rudin C, Dominici F Journal of machine learning research : JMLR 34335110 J Mach Learn Res 2019 https://www.ncbi.nlm.nih.gov/pubmed/34335110
Identifying undercompensated groups defined by multiple attributes in risk adjustment. Zink A, Rose S BMJ health & care informatics 34535447 BMJ Health Care Inform 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34535447
Air pollution exposure disparities across US population and income groups. Jbaily A, Zhou X, Liu J, Lee TH, Kamareddine L, Verguet S, Dominici F Nature 35022594 Nature 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/35022594
Conditional cross-design synthesis estimators for generalizability in Medicaid. Degtiar I, Layton T, Wallace J, Rose S Biometrics 37018228 Biometrics 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37018228
Reflection on modern methods: when worlds collide-prediction, machine learning and causal inference. Blakely T, Lynch J, Simons K, Bentley R, Rose S International journal of epidemiology 31298274 Int J Epidemiol 2021 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/31298274
Limitations of P-Values and R-squared for Stepwise Regression Building: A Fairness Demonstration in Health Policy Risk Adjustment. Rose S, McGuire TG The American statistician 31263291 Am Stat 2019 https://www.ncbi.nlm.nih.gov/pubmed/31263291
CAUSAL INFERENCE IN THE CONTEXT OF AN ERROR PRONE EXPOSURE: AIR POLLUTION AND MORTALITY. Wu X, Braun D, Kioumourtzoglou MA, Choirat C, Di Q, Dominici F The annals of applied statistics 31649797 Ann Appl Stat 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/31649797
Evaluating Federal Policies Using Bayesian Time Series Models: Estimating the Causal Impact of the Hospital Readmissions Reduction Program. Papadogeorgou G, Menchetti F, Choirat C, Wasfy JH, Zigler CM, Mealli F Health services & outcomes research methodology 39866244 Health Serv Outcomes Res Methodol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/39866244
High-Dimensional Confounding Adjustment Using Continuous Spike and Slab Priors. Antonelli J, Parmigiani G, Dominici F Bayesian analysis 32431779 Bayesian Anal 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/32431779
A causal inference framework for cancer cluster investigations using publicly available data. Nethery RC, Yang Y, Brown AJ, Dominici F Journal of the Royal Statistical Society. Series A, (Statistics in Society) 34262243 J R Stat Soc Ser A Stat Soc 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/34262243
A generalizable data assembly algorithm for infectious disease outbreaks. Majumder MS, Rose S JAMIA open 34350393 JAMIA Open 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34350393
Discussion on "Approval policies for modifications to machine learning-based software as a medical device: A study of biocreep" by Jean Feng, Scott Emerson, and Noah Simon. Rose S Biometrics 33040334 Biometrics 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33040334
Considerations for outcome-dependent biased sampling in health databases. Rose S Statistics in medicine 31489684 Stat Med 2019 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/31489684
Improving the Performance of Risk Adjustment Systems: Constrained Regressions, Reinsurance, and Variable Selection. McGuire TG, Zink AL, Rose S American journal of health economics 34869790 Am J Health Econ 2021 Fall https://www.ncbi.nlm.nih.gov/pubmed/34869790
Discovering Heterogeneous Exposure Effects Using Randomization Inference in Air Pollution Studies. Lee K, Small DS, Dominici F Journal of the American Statistical Association 36311902 J Am Stat Assoc 2021 https://www.ncbi.nlm.nih.gov/pubmed/36311902
Uncertainty in lung cancer stage for survival estimation via set-valued classification. Bergquist S, Brooks GA, Landrum MB, Keating NL, Rose S Statistics in medicine 35675972 Stat Med 2022 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/35675972
Data Source Concordance for Infectious Disease Epidemiology. Majumder M, Cusick MM, Rose S medRxiv : the preprint server for health sciences 35677068 medRxiv 2022 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/35677068
Measuring concordance of data sources used for infectious disease research in the USA: a retrospective data analysis. Majumder MS, Cusick M, Rose S BMJ open 36854597 BMJ Open 2023 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/36854597
Incidence, Persistence, and Steady-State Prevalence in Coding Intensity for Health Plan Payment. McGuire TG, Enache OM, Chernew M, McWilliams JM, Nham T, Rose S Health services research 41204802 Health Serv Res 2026 Feb https://www.ncbi.nlm.nih.gov/pubmed/41204802
Machine Learning for Prediction in Electronic Health Data. Rose S JAMA network open 30646089 JAMA Netw Open 2018 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/30646089
Considerations Across Three Cultures: Parametric Regressions, Interpretable Algorithms, and Complex Algorithms. Eloyan A, Rose S Observational studies 34485997 Obs Stud 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34485997
Evaluation of the health impacts of the 1990 Clean Air Act Amendments using causal inference and machine learning. Nethery RC, Mealli F, Sacks JD, Dominici F Journal of the American Statistical Association 33424062 J Am Stat Assoc 2020 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/33424062
Fair regression for health care spending. Zink A, Rose S Biometrics 31860120 Biometrics 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/31860120
Causal inference in high dimensions: A marriage between Bayesian modeling and good frequentist properties. Antonelli J, Papadogeorgou G, Dominici F Biometrics 33349923 Biometrics 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/33349923
Incidence, Persistence, and Steady-State Prevalence in Coding Intensity for Health Plan Payment. McGuire TG, Enache OM, Chernew M, McWilliams JM, Nham T, Rose S medRxiv : the preprint server for health sciences 40321285 medRxiv 2025 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/40321285
Assessment of Changes in the Geographical Distribution of Opioid-Related Mortality Across the United States by Opioid Type, 1999-2016. Kiang MV, Basu S, Chen J, Alexander MJ JAMA network open 30794299 JAMA Netw Open 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30794299
Detecting Heterogeneous Treatment Effects to Guide Personalized Blood Pressure Treatment: A Modeling Study of Randomized Clinical Trials. Basu S, Sussman JB, Hayward RA Annals of internal medicine 28055048 Ann Intern Med 2017 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/28055048
Health Behaviors, Mental Health, and Health Care Utilization Among Single Mothers After Welfare Reforms in the 1990s. Basu S, Rehkopf DH, Siddiqi A, Glymour MM, Kawachi I American journal of epidemiology 26946395 Am J Epidemiol 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26946395
Evaluating the Health Impact of Large-Scale Public Policy Changes: Classical and Novel Approaches. Basu S, Meghani A, Siddiqi A Annual review of public health 28384086 Annu Rev Public Health 2017 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/28384086
Basu et al. Respond to "Interdisciplinary Approach for Policy Evaluation". Basu S, Rehkopf DH, Siddiqi A, Glymour MM, Kawachi I American journal of epidemiology 26946397 Am J Epidemiol 2016 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/26946397
The Monthly Cycle of Hypoglycemia: An Observational Claims-based Study of Emergency Room Visits, Hospital Admissions, and Costs in a Commercially Insured Population. Basu S, Berkowitz SA, Seligman H Medical care 28481762 Med Care 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28481762
Cost Effectiveness of Subsidizing Fruit and Vegetable Purchases Through the Supplemental Nutrition Assistance Program. Choi SE, Seligman H, Basu S American journal of preventive medicine 28153648 Am J Prev Med 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28153648
Supplemental Nutrition Assistance Program (SNAP) Participation and Health Care Expenditures Among Low-Income Adults. Berkowitz SA, Seligman HK, Rigdon J, Meigs JB, Basu S JAMA internal medicine 28973507 JAMA Intern Med 2017 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/28973507
Machine learning with sparse nutrition data to improve cardiovascular mortality risk prediction in the USA using nationally randomly sampled data. Rigdon J, Basu S BMJ open 31784446 BMJ Open 2019 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/31784446
Personalizing Second-Line Type 2 Diabetes Treatment Selection: Combining Network Meta-analysis, Individualized Risk, and Patient Preferences for Unified Decision Support. Choi SE, Berkowitz SA, Yudkin JS, Naci H, Basu S Medical decision making : an international journal of the Society for Medical Decision Making 30767632 Med Decis Making 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30767632
Food insecurity, healthcare utilization, and high cost: a longitudinal cohort study. Berkowitz SA, Seligman HK, Meigs JB, Basu S The American journal of managed care 30222918 Am J Manag Care 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30222918
Mother's education and late-life disparities in memory and dementia risk among US military veterans and non-veterans. Vable AM, Eng CW, Mayeda ER, Basu S, Marden JR, Hamad R, Glymour MM Journal of epidemiology and community health 30082424 J Epidemiol Community Health 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30082424
Moderation of the Relation of County-Level Cost of Living to Nutrition by the Supplemental Nutrition Assistance Program. Basu S, Wimer C, Seligman H American journal of public health 27631742 Am J Public Health 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27631742
Evaluating strategies for control of tuberculosis in prisons and prevention of spillover into communities: An observational and modeling study from Brazil. Mabud TS, de Lourdes Delgado Alves M, Ko AI, Basu S, Walter KS, Cohen T, Mathema B, Colijn C, Lemos E, Croda J, Andrews JR PLoS medicine 30677013 PLoS Med 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30677013
Association between access to social service resources and cardiometabolic risk factors: a machine learning and multilevel modeling analysis. Berkowitz SA, Basu S, Venkataramani A, Reznor G, Fleegler EW, Atlas SJ BMJ open 30862634 BMJ Open 2019 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/30862634
Anticipated burden and mitigation of carbon-dioxide-induced nutritional deficiencies and related diseases: A simulation modeling study. Weyant C, Brandeau ML, Burke M, Lobell DB, Bendavid E, Basu S PLoS medicine 29969442 PLoS Med 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29969442
Illustrating a "consequential" shift in the study of health inequalities: a decomposition of racial differences in the distribution of body mass. Siddiqi A, Shahidi FV, Hildebrand V, Hong A, Basu S Annals of epidemiology 29576050 Ann Epidemiol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29576050
BOUNDS ON THE CONDITIONAL AND AVERAGE TREATMENT EFFECT WITH UNOBSERVED CONFOUNDING FACTORS. Yadlowsky S, Namkoong H, Basu S, Duchi J, Tian L Annals of statistics 38050638 Ann Stat 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/38050638
Health and Economic Implications of National Treatment Coverage for Cardiovascular Disease in India: Cost-Effectiveness Analysis. Basu S, Bendavid E, Sood N Circulation. Cardiovascular quality and outcomes 26555122 Circ Cardiovasc Qual Outcomes 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26555122
Near-Far Matching in R: The nearfar Package. Rigdon J, Baiocchi M, Basu S Journal of statistical software 30386186 J Stat Softw 2018 https://www.ncbi.nlm.nih.gov/pubmed/30386186
Huntington's disease in the United States: Variation by demographic and socioeconomic factors. Bruzelius E, Scarpa J, Zhao Y, Basu S, Faghmous JH, Baum A Movement disorders : official journal of the Movement Disorder Society 30868663 Mov Disord 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30868663
Detecting Anomalies Among Practice Sites Within Multicenter Trials. Berkowitz SA, Rudolph KE, Basu S Circulation. Cardiovascular quality and outcomes 30857413 Circ Cardiovasc Qual Outcomes 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30857413
Alternative Strategies to Achieve Cardiovascular Mortality Goals in China and India: A Microsimulation of Target- Versus Risk-Based Blood Pressure Treatment. Basu S, Yudkin JS, Sussman JB, Millett C, Hayward RA Circulation 26762520 Circulation 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26762520
Are There Spillover Effects from the GI Bill? The Mental Health of Wives of Korean War Veterans. Vable AM, Kawachi I, Canning D, Glymour MM, Jimenez MP, Subramanian SV PloS one 27186983 PLoS One 2016 https://www.ncbi.nlm.nih.gov/pubmed/27186983
A New Tool for Case Studies in Epidemiology-the Synthetic Control Method. Rehkopf DH, Basu S Epidemiology (Cambridge, Mass.) 29613871 Epidemiology 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29613871
Military Service, Childhood Socio-Economic Status, and Late-Life Lung Function: Korean War Era Military Service Associated with Smaller Disparities. Vable AM, Kiang MV, Basu S, Rudolph KE, Kawachi I, Subramanian SV, Glymour MM Military medicine 29509934 Mil Med 2018 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/29509934
Clinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk. Yadlowsky S, Hayward RA, Sussman JB, McClelland RL, Min YI, Basu S Annals of internal medicine 29868850 Ann Intern Med 2018 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/29868850
Validation of Risk Equations for Complications of Type 2 Diabetes (RECODe) Using Individual Participant Data From Diverse Longitudinal Cohorts in the U.S. Basu S, Sussman JB, Berkowitz SA, Hayward RA, Bertoni AG, Correa A, Mwasongwe S, Yudkin JS Diabetes care 29269511 Diabetes Care 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29269511
Characteristics Associated With Decreased or Increased Mortality Risk From Glycemic Therapy Among Patients With Type 2 Diabetes and High Cardiovascular Risk: Machine Learning Analysis of the ACCORD Trial. Basu S, Raghavan S, Wexler DJ, Berkowitz SA Diabetes care 29279299 Diabetes Care 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29279299
Preventing false discovery of heterogeneous treatment effect subgroups in randomized trials. Rigdon J, Baiocchi M, Basu S Trials 30012181 Trials 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30012181
Black-White Cardiovascular Disease Disparities After Target-Based Versus Personalized Benefit-Based Lipid and Blood Pressure Treatment. Basu S, Sussman JB, Hayward RA MDM policy & practice 30288429 MDM Policy Pract 2017 Jul-Dec https://www.ncbi.nlm.nih.gov/pubmed/30288429
Decomposition of the US black/white inequality in premature mortality, 2010-2015: an observational study. Kiang MV, Krieger N, Buckee CO, Onnela JP, Chen JT BMJ open 31748287 BMJ Open 2019 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/31748287
Personalizing Medical Treatment Decisions: Integrating Meta-analytic Treatment Comparisons with Patient-Specific Risks and Preferences. Weyant C, Brandeau ML, Basu S Medical decision making : an international journal of the Society for Medical Decision Making 31707910 Med Decis Making 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31707910
Comparative effectiveness and cost-effectiveness of treat-to-target versus benefit-based tailored treatment of type 2 diabetes in low-income and middle-income countries: a modelling analysis. Basu S, Shankar V, Yudkin JS The lancet. Diabetes & endocrinology 27717768 Lancet Diabetes Endocrinol 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27717768
Food Insecurity and Health Care Expenditures in the United States, 2011-2013. Berkowitz SA, Basu S, Meigs JB, Seligman HK Health services research 28608473 Health Serv Res 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/28608473
Impact of the North American Free Trade Agreement on high-fructose corn syrup supply in Canada: a natural experiment using synthetic control methods. Barlow P, McKee M, Basu S, Stuckler D CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 28676578 CMAJ 2017 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/28676578
Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial. Baum A, Scarpa J, Bruzelius E, Tamler R, Basu S, Faghmous J The lancet. Diabetes & endocrinology 28711469 Lancet Diabetes Endocrinol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28711469
Machine Learning Methods for Precision Medicine Research Designed to Reduce Health Disparities: A Structured Tutorial. Basu S, Faghmous JH, Doupe P Ethnicity & disease 32269464 Ethn Dis 2020 https://www.ncbi.nlm.nih.gov/pubmed/32269464
Development and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials. Basu S, Sussman JB, Berkowitz SA, Hayward RA, Yudkin JS The lancet. Diabetes & endocrinology 28803840 Lancet Diabetes Endocrinol 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28803840
Dynamic treatment selection and modification for personalised blood pressure therapy using a Markov decision process model: a cost-effectiveness analysis. Choi SE, Brandeau ML, Basu S BMJ open 29146652 BMJ Open 2017 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/29146652
Re-evaluating associations between the Supplemental Nutrition Assistance Program participation and body mass index in the context of unmeasured confounders. Rigdon J, Berkowitz SA, Seligman HK, Basu S Social science & medicine (1982) 28965002 Soc Sci Med 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28965002
Matching Microsimulation Risk Factor Correlations to Cross-sectional Data: The Shortest Distance Method. Suen SC, Goldhaber-Fiebert JD, Basu S Medical decision making : an international journal of the Society for Medical Decision Making 29185378 Med Decis Making 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29185378
Benefit and harm of intensive blood pressure treatment: Derivation and validation of risk models using data from the SPRINT and ACCORD trials. Basu S, Sussman JB, Rigdon J, Steimle L, Denton BT, Hayward RA PLoS medicine 29040268 PLoS Med 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/29040268
Generalizing Intensive Blood Pressure Treatment to Adults With Diabetes Mellitus. Berkowitz SA, Sussman JB, Jonas DE, Basu S Journal of the American College of Cardiology 30189998 J Am Coll Cardiol 2018 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/30189998
Long-term effects of neighbourhood deprivation on diabetes risk: quasi-experimental evidence from a refugee dispersal policy in Sweden. White JS, Hamad R, Li X, Basu S, Ohlsson H, Sundquist J, Sundquist K The lancet. Diabetes & endocrinology 27131930 Lancet Diabetes Endocrinol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27131930
Association of Primary Care Physician Supply With Population Mortality in the United States, 2005-2015. Basu S, Berkowitz SA, Phillips RL, Bitton A, Landon BE, Phillips RS JAMA internal medicine 30776056 JAMA Intern Med 2019 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/30776056
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mL-BFGS: A Momentum-based L-BFGS for Distributed Large-Scale Neural Network Optimization. Niu Y, Fabian Z, Lee S, Soltanolkotabi M, Avestimehr S Transactions on machine learning research 40896294 Transact Mach Learn Res 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/40896294
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Deep Learning-Based Control of Electrically Evoked Activity in Human Visual Cortex. Moure P, Granley J, Grani F, Soo L, Lozano A, López-Peco R, Villamarin-Ortiz A, Soto-Sanchez C, Liu SC, Beyeler M, Fernández E bioRxiv : the preprint server for biology 41279945 bioRxiv 2025 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/41279945
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Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias. Haghighi K, Gardner G, Vafiadaki E, Kumar M, Green LC, Ma J, Crocker JS, Koch S, Arvanitis DA, Bidwell P, Rubinstein J, van de Leur R, Doevendans PA, Akar FG, Tranter M, Wang HS, Sadayappan S, DeMazumder D, Sanoudou D, Hajjar RJ, Stillitano F, Kranias EG Journal of personalized medicine 34204946 J Pers Med 2021 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/34204946
Contemporary Applications of Machine Learning for Device Therapy in Heart Failure. Gautam N, Ghanta SN, Clausen A, Saluja P, Sivakumar K, Dhar G, Chang Q, DeMazumder D, Rabbat MG, Greene SJ, Fudim M, Al'Aref SJ JACC. Heart failure 36049812 JACC Heart Fail 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36049812
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Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts. Joshi P, Estes S, DeMazumder D, Knollmann BC, Dey S eLife 38078905 Elife 2023 Dec 11 https://www.ncbi.nlm.nih.gov/pubmed/38078905
SEMTWIST Quantification of Biofilm Infection in Human Chronic Wound Using Scanning Electron Microscopy and Machine Learning. Singh S, Muniz De Oliveira F, Wang C, Kumar M, Xuan Y, DeMazumder D, Sen CK, Roy S Advances in wound care 40358506 Adv Wound Care (New Rochelle) 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40358506
Cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity. Dey S, Joshi P, O'Rourke B, Estes S, DeMazumder D bioRxiv : the preprint server for biology 36778270 bioRxiv 2023 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/36778270
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Neurocardiac Changes Preceding and During the Onset of Takotsubo Cardiomyopathy in the Cardiac Electrophysiology Laboratory. Thirumal R, Wittstein IS, Calkins H, DeMazumder D JACC. Clinical electrophysiology 35210091 JACC Clin Electrophysiol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35210091
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TET2-mutant clonal hematopoiesis and risk of gout. Agrawal M, Niroula A, Cunin P, McConkey M, Shkolnik V, Kim PG, Wong WJ, Weeks LD, Lin AE, Miller PG, Gibson CJ, Sekar A, Schaefer IM, Neuberg D, Stone RM, Bick AG, Uddin MM, Griffin GK, Jaiswal S, Natarajan P, Nigrovic PA, Rao DA, Ebert BL Blood 35714308 Blood 2022 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/35714308
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias. Schuermans A, Vlasschaert C, Nauffal V, Cho SMJ, Uddin MM, Nakao T, Niroula A, Klarqvist MDR, Weeks LD, Lin AE, Saadatagah S, Lannery K, Wong M, Hornsby W, Lubitz SA, Ballantyne C, Jaiswal S, Libby P, Ebert BL, Bick AG, Ellinor PT, Natarajan P, Honigberg MC European heart journal 37952204 Eur Heart J 2024 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/37952204
Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease. Gumuser ED, Schuermans A, Cho SMJ, Sporn ZA, Uddin MM, Paruchuri K, Nakao T, Yu Z, Haidermota S, Hornsby W, Weeks LD, Niroula A, Jaiswal S, Libby P, Ebert BL, Bick AG, Natarajan P, Honigberg MC Journal of the American College of Cardiology 37197843 J Am Coll Cardiol 2023 May 23 https://www.ncbi.nlm.nih.gov/pubmed/37197843
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Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate. Mack TM, Raddatz MA, Pershad Y, Nachun DC, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Kenny EE, Loos RJF, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Cho MH, DeMeo DL, Levy D, Johnson AD, Mathias RA, Yanek LR, Heckbert SR, Smith NL, Wiggins KL, Raffield LM, Carson AP, Rotter JI, Rich SS, Manichaikul AW, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Roden DM, Kooperberg C, Auer PL, Desai P, Blackwell TW, Smith AV, Reiner AP, Jaiswal S, Weinstock JS, Bick AG Nature aging 38834882 Nat Aging 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38834882
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. Nachun D, Lu AT, Bick AG, Natarajan P, Weinstock J, Szeto MD, Kathiresan S, Abecasis G, Taylor KD, Guo X, Tracy R, Durda P, Liu Y, Johnson C, Rich SS, Van Den Berg D, Laurie C, Blackwell T, Papanicolaou GJ, Correa A, Raffield LM, Johnson AD, Murabito J, Manson JE, Desai P, Kooperberg C, Assimes TL, Levy D, Rotter JI, Reiner AP, Whitsel EA, Wilson JG, Horvath S, Jaiswal S, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Aging cell 34050697 Aging Cell 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34050697
Insights into clonal hematopoiesis and its relation to cancer risk. Mitchell SR, Gopakumar J, Jaiswal S Current opinion in genetics & development 33422951 Curr Opin Genet Dev 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33422951
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ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Gallì A, Castellano CA, McConkey M, Tarun A, Wong W, Schenone M, Stanclift C, Tanenbaum B, Malolepsza E, Nilsson B, Bick AG, Weinstock JS, Miller M, Niroula A, Dunford A, Taylor-Weiner A, Wood T, Barbera A, Anand S, Psaty BM, Desai P, Cho MH, Johnson AD, Loos R, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, MacArthur DG, Lek M, Exome Aggregation Consortium, Neuberg DS, Lage K, Carr SA, Hellstrom-Lindberg E, Malcovati L, Papaemmanuil E, Stewart C, Getz G, Bradley RK, Jaiswal S, Ebert BL Blood cancer discovery 34568833 Blood Cancer Discov 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34568833
Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self. Chowdhury RR, D'Addabbo J, Huang X, Veizades S, Sasagawa K, Louis DM, Cheng P, Sokol J, Jensen A, Tso A, Shankar V, Wendel BS, Bakerman I, Liang G, Koyano T, Fong R, Nau AN, Ahmad H, Gopakumar J, Wirka R, Lee AS, Boyd J, Woo YJ, Quertermous T, Gulati GS, Jaiswal S, Chien YH, Chan CKF, Davis MM, Nguyen PK Circulation research 35430876 Circ Res 2022 May 13 https://www.ncbi.nlm.nih.gov/pubmed/35430876
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, Sharber B, Silver AJ, Xu Y, Savona M, Gibson C, Lanktree MB, Rauh MJ, Ebert BL, Natarajan P, Jaiswal S, Bick AG Blood 36652671 Blood 2023 May 4 https://www.ncbi.nlm.nih.gov/pubmed/36652671
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, Niroula A, Carty CL, Lane J, Honigberg MC, Weinstock JS, Pampana A, Gibson CJ, Griffin GK, Clarke SL, Bhattacharya R, Assimes TL, Emery LS, Stilp AM, Wong Q, Broome J, Laurie CA, Khan AT, Smith AV, Blackwell TW, Codd V, Nelson CP, Yoneda ZT, Peralta JM, Bowden DW, Irvin MR, Boorgula M, Zhao W, Yanek LR, Wiggins KL, Hixson JE, Gu CC, Peloso GM, Roden DM, Reupena MS, Hwu CM, DeMeo DL, North KE, Kelly S, Musani SK, Bis JC, Lloyd-Jones DM, Johnsen JM, Preuss M, Tracy RP, Peyser PA, Qiao D, Desai P, Curran JE, Freedman BI, Tiwari HK, Chavan S, Smith JA, Smith NL, Kelly TN, Hidalgo B, Cupples LA, Weeks DE, Hawley NL, Minster RL, Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Deka R, Naseri TT, de las Fuentes L, Raffield LM, Morrison AC, Vries PS, Ballantyne CM, Kenny EE, Rich SS, Whitsel EA, Cho MH, Shoemaker MB, Pace BS, Blangero J, Palmer ND, Mitchell BD, Shuldiner AR, Barnes KC, Redline S, Kardia SLR, Abecasis GR, Becker LC, Heckbert SR, He J, Post W, Arnett DK, Vasan RS, Darbar D, Weiss ST, McGarvey ST, de Andrade M, Chen YI, Kaplan RC, Meyers DA, Custer BS, Correa A, Psaty BM, Fornage M, Manson JE, Boerwinkle E, Konkle BA, Loos RJF, Rotter JI, Silverman EK, Kooperberg C, Danesh J, Samani NJ, Jaiswal S, Libby P, Ellinor PT, Pankratz N, Ebert BL, Reiner AP, Mathias RA, Do R, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Natarajan P Science advances 35385311 Sci Adv 2022 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/35385311
Clonal haematopoiesis and atherosclerotic cardiovascular disease. Ahmad H, Jaiswal S Nature reviews. Cardiology 37169832 Nat Rev Cardiol 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37169832
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics. Uddin MM, Zhou Y, Bick AG, Burugula BB, Jaiswal S, Desai P, Honigberg MC, Love SA, Barac A, Hayden KM, Manson JE, Whitsel EA, Kooperberg C, Natarajan P, Reiner AP, Kitzman JO Immunity & ageing : I & A 35610705 Immun Ageing 2022 May 24 https://www.ncbi.nlm.nih.gov/pubmed/35610705
Single cell RNA sequencing of haematopoietic cells in fresh and frozen human atheroma tissue. Ahmad H, Gopakumar J, Nachun DC, Ma L, D'Addabbo J, Huang X, Koyano T, Boyd J, Woo YJ, Fong R, Aalami O, Nguyen PK, Jaiswal S Cardiovascular research 39907372 Cardiovasc Res 2025 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/39907372
Clonal haematopoiesis and risk of chronic liver disease. Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, Dichtel L, Griffin G, Uddin MM, Gibson CJ, Kovalcik V, Lin AE, McConkey ME, Vromman A, Sellar RS, Kim PG, Agrawal M, Weinstock J, Long MT, Yu B, Banerjee R, Nicholls RC, Dennis A, Kelly M, Loh PR, McCarroll S, Boerwinkle E, Vasan RS, Jaiswal S, Johnson AD, Chung RT, Corey K, Levy D, Ballantyne C, NHLBI TOPMed Hematology Working Group, Ebert BL, Natarajan P Nature 37046084 Nature 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/37046084
Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. Jaiswal S, Libby P Nature reviews. Cardiology 31406340 Nat Rev Cardiol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31406340
Clonal Hematopoiesis and Its Impact on Human Health. Ahmad H, Jahn N, Jaiswal S Annual review of medicine 36450282 Annu Rev Med 2023 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/36450282
Prediction of risk for myeloid malignancy in clonal hematopoiesis. Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL NEJM evidence 37483562 NEJM Evid 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37483562
Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood. Schuermans A, Nakao T, Ruan Y, Koyama S, Yu Z, Uddin MM, Haidermota S, Hornsby W, Lewandowski AJ, Bick AG, Niroula A, Jaiswal S, Ebert BL, Natarajan P, Honigberg MC Journal of the American Heart Association 37345823 J Am Heart Assoc 2023 Jul 4 https://www.ncbi.nlm.nih.gov/pubmed/37345823
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. Uddin MDM, Nguyen NQH, Yu B, Brody JA, Pampana A, Nakao T, Fornage M, Bressler J, Sotoodehnia N, Weinstock JS, Honigberg MC, Nachun D, Bhattacharya R, Griffin GK, Chander V, Gibbs RA, Rotter JI, Liu C, Baccarelli AA, Chasman DI, Whitsel EA, Kiel DP, Murabito JM, Boerwinkle E, Ebert BL, Jaiswal S, Floyd JS, Bick AG, Ballantyne CM, Psaty BM, Natarajan P, Conneely KN Nature communications 36097025 Nat Commun 2022 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/36097025
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia. Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M Blood 36130297 Blood 2022 Nov 24 https://www.ncbi.nlm.nih.gov/pubmed/36130297
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis. Weinstock JS, Gopakumar J, Burugula BB, Uddin MM, Jahn N, Belk JA, Bouzid H, Daniel B, Miao Z, Ly N, Mack TM, Luna SE, Prothro KP, Mitchell SR, Laurie CA, Broome JG, Taylor KD, Guo X, Sinner MF, von Falkenhausen AS, Kääb S, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Hou L, Lloyd-Jones DM, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Palmer ND, Freedman BI, Bowden DW, Cho MH, DeMeo DL, Vasan RS, Yanek LR, Becker LC, Kardia SLR, Peyser PA, He J, Rienstra M, Van der Harst P, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Cutler MJ, Knight S, Muhlestein JB, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Tracy RP, Konkle BA, Johnsen JM, Wheeler MM, Smith JG, Melander O, Nilsson PM, Custer BS, Duggirala R, Curran JE, Blangero J, McGarvey S, Williams LK, Xiao S, Yang M, Gu CC, Chen YI, Lee WJ, Marcus GM, Kane JP, Pullinger CR, Shoemaker MB, Darbar D, Roden DM, Albert C, Kooperberg C, Zhou Y, Manson JE, Desai P, Johnson AD, Mathias RA, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Satpathy AT, Natarajan P, Kitzman JO, Whitsel EA, Reiner AP, Bick AG, Jaiswal S Nature 37046083 Nature 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/37046083
Human Plasma Proteomic Profile of Clonal Hematopoiesis. Yu Z, Vromman A, Nguyen NQH, Schuermans A, Rentz T, Vellarikkal SK, Uddin MM, Niroula A, Griffin G, Honigberg MC, Lin AE, Gibson CJ, Katz DH, Tahir U, Fang S, Haidermota S, Ganesh S, Antoine T, Weinstock J, Austin TR, Ramachandran VS, Peloso GM, Hornsby W, Ganz P, Manson JE, Haring B, Kooperberg CL, Reiner AP, Bis JC, Psaty BM, Min YI, Correa A, Lange LA, Post WS, Rotter JI, Rich SS, Wilson JG, Ebert BL, Yu B, Ballantyne CM, Coresh J, Sankaran VG, Bick AG, Jaiswal S, Gerszten RE, NHLBI Trans-Omics for Precision Medicine, Libby P, Gupta RM, Natarajan P bioRxiv : the preprint server for biology 39554199 bioRxiv 2024 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/39554199
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk. Choi SH, Jurgens SJ, Xiao L, Hill MC, Haggerty CM, Sveinbjörnsson G, Morrill VN, Marston NA, Weng LC, Pirruccello JP, Arnar DO, Gudbjartsson DF, Mantineo H, von Falkenhausen AS, Natale A, Tveit A, Geelhoed B, Roselli C, Van Wagoner DR, Darbar D, Haase D, Soliman EZ, Davogustto GE, Jun G, Calkins H, Anderson JL, Brody JA, Halford JL, Barnard J, Hokanson JE, Smith JD, Bis JC, Young K, Johnson LSB, Risch L, Gula LJ, Kwee LC, Chaffin MD, Kühne M, Preuss M, Gupta N, Nafissi NA, Smith NL, Nilsson PM, van der Harst P, Wells QS, Judy RL, Schnabel RB, Johnson R, Smit RAJ, Gabriel S, Knight S, Furukawa T, Blackwell TW, Nauffal V, Wang X, Min YI, Yoneda ZT, Laksman ZWM, Bezzina CR, Alonso A, Psaty BM, Albert CM, Arking DE, Roden DM, Chasman DI, Rader DJ, Conen D, McManus DD, Fatkin D, Benjamin EJ, Boerwinkle E, Marcus GM, Christophersen IE, Smith JG, Roberts JD, Raffield LM, Shoemaker MB, Cho MH, Cutler MJ, Rienstra M, Chung MK, S Olesen M, Sinner MF, Sotoodehnia N, Kirchhof P, Loos RJF, Nazarian S, Mohanty S, Damrauer SM, Kaab S, Heckbert SR, Redline S, Shah SH, Tanaka T, Ebana Y, Regeneron Genetics Center, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Holm H, Stefansson K, Ruff CT, Sabatine MS, Lunetta KL, Lubitz SA, Ellinor PT Nature genetics 40050430 Nat Genet 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/40050430
Human plasma proteomic profile of clonal hematopoiesis. Yu Z, Vromman A, Nguyen NQH, Schuermans A, Li L, Rentz T, Nakao T, Vellarikkal SK, Uddin MM, Niroula A, Griffin G, Honigberg MC, Lin AE, Gibson CJ, Katz DH, Tahir UA, Fang S, Dron JS, Pan M, Haidermota S, Ganesh S, Antoine T, Weinstock J, Austin TR, Vasan RS, Peloso GM, Hornsby W, Ganz P, Manson JE, Haring B, Kooperberg C, Reiner AP, Bis JC, Psaty BM, Min YI, Correa A, Lange LA, Post WS, Rotter JI, Rich SS, Wilson JG, Ebert BL, Yu B, Ballantyne CM, Coresh J, Sankaran VG, Bick AG, Jaiswal S, Gerszten RE, NHLBI Trans-Omics for Precision Medicine, Libby P, Gupta RM, Natarajan P Nature communications 41309676 Nat Commun 2025 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/41309676
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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL The Journal of experimental medicine 34698806 J Exp Med 2021 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/34698806
Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. Bhattacharya R, Zekavat SM, Haessler J, Fornage M, Raffield L, Uddin MM, Bick AG, Niroula A, Yu B, Gibson C, Griffin G, Morrison AC, Psaty BM, Longstreth WT, Bis JC, Rich SS, Rotter JI, Tracy RP, Correa A, Seshadri S, Johnson A, Collins JM, Hayden KM, Madsen TE, Ballantyne CM, Jaiswal S, Ebert BL, Kooperberg C, Manson JE, Whitsel EA, NHLBI Trans-Omics for Precision Medicine Program, Natarajan P, Reiner AP Stroke 34743536 Stroke 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/34743536
Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, Niroula A, McConkey ME, Sandoval B, Miller BC, Shi W, Viswanathan K, Leventhal M, Werner L, Moll M, Cade BE, Barr RG, Correa A, Cupples LA, Gharib SA, Jain D, Gogarten SM, Lange LA, London SJ, Manichaikul A, O'Connor GT, Oelsner EC, Redline S, Rich SS, Rotter JI, Ramachandran V, Yu B, Sholl L, Neuberg D, Jaiswal S, Levy BD, Owen CA, Natarajan P, Silverman EK, van Galen P, Tesfaigzi Y, Cho MH, Ebert BL, COPDGene Study Investigators, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium Blood 34855941 Blood 2022 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/34855941
Clonal hematopoiesis is associated with protection from Alzheimer's disease. Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S Nature medicine 37322115 Nat Med 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37322115
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, Cade BE, Gilliland FD, Chen Z, Gauderman WJ, Kumar R, Grammer L, Schleimer RP, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Qiao D, Weiss ST, Lasky-Su J, DeMeo DL, Palmer ND, Freedman BI, Bowden DW, Cho MH, Vasan RS, Johnson AD, Yanek LR, Becker LC, Kardia S, He J, Kaplan R, Heckbert SR, Smith NL, Wiggins KL, Arnett DK, Irvin MR, Tiwari H, Correa A, Raffield LM, Gao Y, de Andrade M, Rotter JI, Rich SS, Manichaikul AW, Konkle BA, Johnsen JM, Wheeler MM, Custer BS, Duggirala R, Curran JE, Blangero J, Gui H, Xiao S, Williams LK, Meyers DA, Li X, Ortega V, McGarvey S, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Darbar D, Roden D, Albert C, Kooperberg C, Desai P, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Mathias R, Natarajan P, Jaiswal S, Reiner AP, Bick AG, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Science advances 37126548 Sci Adv 2023 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/37126548
Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement. Sagar R, Almeida-Porada G, Blakemore K, Chan JKY, Choolani M, Götherström C, Jaulent A, MacKenzie TC, Mattar C, Porada CD, Peranteau WH, Schneider H, Shaw SW, Waddington SN, Westgren M, David AL Molecular therapy : the journal of the American Society of Gene Therapy 33069884 Mol Ther 2020 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/33069884
Preexisting maternal immunity to AAV but not Cas9 impairs in utero gene editing in mice. Riley JS, Luks VL, Berkowitz CL, Dumitru AM, Kus NJ, Dave A, Menon P, De Paepe ME, Jain R, Li L, Dugoff L, Teefey CP, Alameh MG, Zoltick PW, Peranteau WH The Journal of clinical investigation 38950310 J Clin Invest 2024 May 9 https://www.ncbi.nlm.nih.gov/pubmed/38950310
The Future of In Utero Gene Therapy. Peranteau WH, Flake AW Molecular diagnosis & therapy 32020561 Mol Diagn Ther 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32020561
Comment on: Premature delivery in the domestic sow in response to in utero delivery of AAV9 to fetal piglets. Dave A, Berkowitz CL, Luks VL, White BM, Palanki R, Carpenter MD, Riley JS, Bose SK, Li H, Li L, Menon PV, Teerdhala S, Ebrahimi M, Zoltick PW, Peranteau WH Gene therapy 36918654 Gene Ther 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36918654
Molecular and Cellular In Utero Therapy. Berkowitz CL, Luks VL, Puc M, Peranteau WH Clinics in perinatology 36328600 Clin Perinatol 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36328600
Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs. Whittaker MN, Testa LC, Brooks DL, Quigley A, Said H, Dwivedi G, Jindal I, Volpp D, Qu P, Wang JZ, Levine MA, Ahrens-Nicklas RC, Li Q, Musunuru K, Alameh MG, Peranteau WH, Wang X bioRxiv : the preprint server for biology 38712058 bioRxiv 2025 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/38712058
In utero pulse injection of isotopic amino acids quantifies protein turnover rates during murine fetal development. Baeza J, Coons BE, Lin Z, Riley J, Mendoza M, Peranteau WH, Garcia BA bioRxiv : the preprint server for biology 37293076 bioRxiv 2023 May 21 https://www.ncbi.nlm.nih.gov/pubmed/37293076
In utero hematopoietic cell transplantation leads to sustained engraftment in a mouse model of Fanconi anemia. Dave A, Liu S, Riley JS, Bose S, Luks V, Berkowitz C, Menon P, Jung S, Li H, Kurre P, Peranteau WH Blood advances 37906519 Blood Adv 2024 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/37906519
Fetal allotransplant recipients are resistant to graft-versus-host disease. Riley JS, McClain LE, Stratigis JD, Coons BE, Bose SK, Dave A, White BM, Li H, Loukogeorgakis SP, Fachin CG, Dias AIBS, Flake AW, Peranteau WH Experimental hematology 36535408 Exp Hematol 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36535408
Immune modulation permits tolerance and engraftment in a murine model of late-gestation transplantation. Riley JS, Berkowitz CL, Luks VL, Dave A, Cyril-Olutayo MC, Pogoriler J, Flake AW, Abdulmalik O, Peranteau WH Blood advances 38941538 Blood Adv 2024 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/38941538
InUtero Gene Therapy: Progress and Challenges. Bose SK, Menon P, Peranteau WH Trends in molecular medicine 34176774 Trends Mol Med 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34176774
Prenatal Gene Therapy for Metabolic Disorders. Coons B, Peranteau WH Clinical obstetrics and gynecology 34652302 Clin Obstet Gynecol 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/34652302
In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH Nature communications 34257302 Nat Commun 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/34257302
Foetal genome editing. Bose SK, Kennedy K, Peranteau WH Current opinion in obstetrics & gynecology 36924409 Curr Opin Obstet Gynecol 2023 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/36924409
Fetal gene therapy. Waddington SN, Peranteau WH, Rahim AA, Boyle AK, Kurian MA, Gissen P, Chan JKY, David AL Journal of inherited metabolic disease 37470194 J Inherit Metab Dis 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37470194
Secret messengers: Extracellular RNA communication in the immune system. Nation GK, Saffold CE, Pua HH Immunological reviews 34542176 Immunol Rev 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34542176
Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution. von Lersner AK, Fernandes F, Ozawa PMM, Jackson M, Masureel M, Ho H, Lima SM, Vagner T, Sung BH, Wehbe M, Franze K, Pua H, Wilson JT, Irish JM, Weaver AM, Di Vizio D, Zijlstra A ACS nano 38578701 ACS Nano 2024 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/38578701
Nasal Epithelial Extracellular Vesicles Correlate with Type 2 Inflammation during Aspirin-induced Respiratory Reactions. Bunn KE, Bressman ZJ, Nation GK, Wu P, Amin T, Lehman C, Lin A, Gray CJ, Laidlaw TM, Cahill KN, Pua HH American journal of respiratory cell and molecular biology 40085481 Am J Respir Cell Mol Biol 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40085481
RNY1 partitions into extracellular vesicles and ribonucleoprotein particles during airway inflammation to regulate macrophage programming. Saffold CE, Richardson AC, Pua HH bioRxiv : the preprint server for biology 41427290 bioRxiv 2025 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/41427290
RNA regulation in immunity. Pua H, Ansel KM Immunological reviews 34816450 Immunol Rev 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34816450
MicroRNAs in Macrophages: Regulators of Activation and Function. Sprenkle NT, Serezani CH, Pua HH Journal of immunology (Baltimore, Md. : 1950) 36724439 J Immunol 2023 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/36724439
Developmental trajectory of extracellular vesicle characteristics from the lungs of preterm infants. Ransom MA, Bunn KE, Negretti NM, Jetter CS, Bressman ZJ, Sucre JMS, Pua HH American journal of physiology. Lung cellular and molecular physiology 36719083 Am J Physiol Lung Cell Mol Physiol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36719083
Extracellular vesicles: mediators of intercellular communication in tissue injury and disease. Berumen Sánchez G, Bunn KE, Pua HH, Rafat M Cell communication and signaling : CCS 34656117 Cell Commun Signal 2021 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/34656117
Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, Van Kaer L Proceedings of the National Academy of Sciences of the United States of America 36574710 Proc Natl Acad Sci U S A 2023 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/36574710
Transcriptome Complexity Disentangled: A Regulatory Molecules Approach. Asiaee A, Abrams ZB, Pua HH, Coombes KR bioRxiv : the preprint server for biology 37131792 bioRxiv 2025 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/37131792
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbrügger U, Falcon-Perez JM, Fu QL, Hill AF, Lenassi M, Lim SK, Mahoney MG, Mohanty S, Möller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas AC, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges EM, Brucale M, Burger D, Carney RP, Cocucci E, Crescitelli R, Hanser E, Harris AL, Haughey NJ, Hendrix A, Ivanov AR, Jovanovic-Talisman T, Kruh-Garcia NA, Ku'ulei-Lyn Faustino V, Kyburz D, Lässer C, Lennon KM, Lötvall J, Maddox AL, Martens-Uzunova ES, Mizenko RR, Newman LA, Ridolfi A, Rohde E, Rojalin T, Rowland A, Saftics A, Sandau US, Saugstad JA, Shekari F, Swift S, Ter-Ovanesyan D, Tosar JP, Useckaite Z, Valle F, Varga Z, van der Pol E, van Herwijnen MJC, Wauben MHM, Wehman AM, Williams S, Zendrini A, Zimmerman AJ, MISEV Consortium, Théry C, Witwer KW Journal of extracellular vesicles 38326288 J Extracell Vesicles 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38326288
Extracellular RNA in oncogenesis, metastasis and drug resistance. Nelson H, Qu S, Franklin JL, Liu Q, Pua HH, Vickers KC, Weaver AM, Coffey RJ, Patton JG RNA biology 39107918 RNA Biol 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/39107918
The emerging role of extracellular vesicles in bronchopulmonary dysplasia. Ransom MA, Blatt AM, Pua HH, Sucre JMS American journal of physiology. Lung cellular and molecular physiology 38469633 Am J Physiol Lung Cell Mol Physiol 2024 May 1 https://www.ncbi.nlm.nih.gov/pubmed/38469633
Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes. Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V Frontiers in physiology 38179138 Front Physiol 2023 https://www.ncbi.nlm.nih.gov/pubmed/38179138
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function. Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V Circulation research 33044128 Circ Res 2020 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/33044128
Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes. Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V bioRxiv : the preprint server for biology 36747643 bioRxiv 2023 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/36747643
Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1. Garbutt TA, Wang Z, Wang H, Ma H, Ruan H, Dong Y, Xie Y, Tan L, Phookan R, Stouffer JA, Vedantham V, Yang Y, Qian L, Liu J Circulation 38223978 Circulation 2024 May 7 https://www.ncbi.nlm.nih.gov/pubmed/38223978
Single Cell Multi-Omics of an iPSC Model of Human Sinoatrial Node Development Reveals Genetic Determinants of Heart Rate and Arrhythmia Susceptibility. Engel JL, Zhang X, Lu DR, Vila OF, Arias V, Lee J, Hale C, Hsu YH, Li CM, Wu RS, Vedantham V, Ang YS bioRxiv : the preprint server for biology 37425707 bioRxiv 2023 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/37425707
Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D Circulation 35938400 Circulation 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/35938400
Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node. Mandla R, Jung C, Vedantham V Frontiers in physiology 34335313 Front Physiol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34335313
On-demand and tunable dual wavelength release of antibody using light-responsive hydrogels. LeValley PJ, Sutherland BP, Jaje J, Gibbs S, Jones M, Gala R, Kloxin CJ, Kiick KL, Kloxin AM ACS applied bio materials 34327309 ACS Appl Bio Mater 2020 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/34327309
Multiscale Invasion Assay for Probing Macrophage Response to Gram-Negative Bacteria. Wodzanowski KA, Caplan JL, Kloxin AM, Grimes CL Frontiers in chemistry 35242744 Front Chem 2022 https://www.ncbi.nlm.nih.gov/pubmed/35242744
Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function. Bomb K, Pradhan L, Zhang Q, Jarai BM, Bhattacharjee A, Burris DL, Kloxin AM, Fromen CA Biomaterials science 36018297 Biomater Sci 2022 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/36018297
Harnessing multifunctional collagen mimetic peptides to create bioinspired stimuli responsive hydrogels for controlled cell culture. Ford EM, Hilderbrand AM, Kloxin AM Journal of materials chemistry. B 39211975 J Mater Chem B 2024 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/39211975
Effects of solvent conditions on the self-assembly of heterotrimeric collagen-like peptide (CLP) triple helices: a coarse-grained simulation study. Taylor PA, Kronenberger S, Kloxin AM, Jayaraman A Soft matter 37340986 Soft Matter 2023 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/37340986
Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations. Cassel SE, Huntington BM, Chen W, Lei P, Andreadis ST, Kloxin AM APL bioengineering 38938687 APL Bioeng 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38938687
Tools for probing host-bacteria interactions in the gut microenvironment: From molecular to cellular levels. Wodzanowski KA, Cassel SE, Grimes CL, Kloxin AM Bioorganic & medicinal chemistry letters 32223923 Bioorg Med Chem Lett 2020 May 15 https://www.ncbi.nlm.nih.gov/pubmed/32223923
Rational Design of Hydrogel Networks with Dynamic Mechanical Properties to Mimic Matrix Remodeling. Wiley KL, Sutherland BP, Ogunnaike BA, Kloxin AM Advanced healthcare materials 34936227 Adv Healthc Mater 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/34936227
On the path to predicting immune responses in the lung: Modeling the pulmonary innate immune system at the air-liquid interface (ALI). Graf J, Trautmann-Rodriguez M, Sabnis S, Kloxin AM, Fromen CA European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 37770004 Eur J Pharm Sci 2023 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/37770004
Engineered hydrogels for mechanobiology. Blache U, Ford EM, Ha B, Rijns L, Chaudhuri O, Dankers PYW, Kloxin AM, Snedeker JG, Gentleman E Nature reviews. Methods primers 37461429 Nat Rev Methods Primers 2022 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/37461429
High-throughput bioprinted 3D cultures for probing host-pathogen interactions in bioinspired microenvironments. Graf J, Moore D, Grimes CL, Fromen CA, Kloxin AM RSC applied polymers 41602571 RSC Appl Polym 2026 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/41602571
Combining simulations and experiments for the molecular engineering of multifunctional collagen mimetic peptide-based materials. Hilderbrand AM, Taylor PA, Stanzione F, LaRue M, Guo C, Jayaraman A, Kloxin AM Soft matter 33434255 Soft Matter 2021 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/33434255
Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials. Sutherland BP, LeValley PJ, Bischoff DJ, Kloxin AM, Kloxin CJ Chemical communications (Cambridge, England) 32820777 Chem Commun (Camb) 2020 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/32820777
Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19. Jarai BM, Stillman Z, Bomb K, Kloxin AM, Fromen CA ACS biomaterials science & engineering 33356134 ACS Biomater Sci Eng 2021 May 10 https://www.ncbi.nlm.nih.gov/pubmed/33356134
Rapid Production of Multifunctional Self-Assembling Peptides for Incorporation and Visualization within Hydrogel Biomaterials. Ford EM, Kloxin AM ACS biomaterials science & engineering 34283566 ACS Biomater Sci Eng 2021 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/34283566
Microgels Formed by Spontaneous Click Chemistries Utilizing Microfluidic Flow Focusing for Cargo Release in Response to Endogenous or Exogenous Stimuli. LeValley PJ, Parsons AL, Sutherland BP, Kiick KL, Oakey JS, Kloxin AM Pharmaceutics 35631649 Pharmaceutics 2022 May 15 https://www.ncbi.nlm.nih.gov/pubmed/35631649
Impact of collagen-like peptide (CLP) heterotrimeric triple helix design on helical thermal stability and hierarchical assembly: a coarse-grained molecular dynamics simulation study. Taylor PA, Kloxin AM, Jayaraman A Soft matter 35380571 Soft Matter 2022 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/35380571
Dynamic bioinspired coculture model for probing ER(+) breast cancer dormancy in the bone marrow niche. Pradhan L, Moore D, Ovadia EM, Swedzinski SL, Cossette T, Sikes RA, van Golen K, Kloxin AM Science advances 36888709 Sci Adv 2023 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/36888709
Macrophage variance: investigating how macrophage origin influences responses to soluble and physical cues with immortalized vs. primary cells in 2D and 3D culture. Graf J, Bomb K, Trautmann-Rodriguez M, Jarai BM, Gill N, Kloxin AM, Fromen CA Frontiers in biomaterials science 40740983 Front Biomater Sci 2024 https://www.ncbi.nlm.nih.gov/pubmed/40740983
Systematic d-Amino Acid Substitutions to Control Peptide and Hydrogel Degradation in Cellular Microenvironments. Bomb K, Zhang Q, Ford EM, Fromen CA, Kloxin AM ACS macro letters 37195203 ACS Macro Lett 2023 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/37195203
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Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses. Wang M, Lee-Kim VS, Atri DS, Elowe NH, Yu J, Garvie CW, Won HH, Hadaya JE, MacDonald BT, Trindade K, Melander O, Rader DJ, Natarajan P, Kathiresan S, Kaushik VK, Khera AV, Gupta RM Circulation. Genomic and precision medicine 34592835 Circ Genom Precis Med 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34592835
CRISPR-Cas9 Genome Editing of Primary Human Vascular Cells In Vitro. Atri DS, Lee-Kim VS, Vellarikkal SK, Sias-Garcia O, Yanamandala M, Schniztler GR, Gupta RM Current protocols 34748284 Curr Protoc 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34748284
Integrative analysis of single-cell transcriptomics and genetic associations identify cell states associated with vascular disease. Pepin ME, Schwartzman WE, Fang S, Vellarikkal SK, Atri DS, Reddy A, Xu Q, Hamel AR, Billaud M, Segrè AV, Gupta RM Atherosclerosis 40120433 Atherosclerosis 2025 Apr https://www.ncbi.nlm.nih.gov/pubmed/40120433
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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases. Weeks EM, Ulirsch JC, Cheng NY, Trippe BL, Fine RS, Miao J, Patwardhan TA, Kanai M, Nasser J, Fulco CP, Tashman KC, Aguet F, Li T, Ordovas-Montanes J, Smillie CS, Biton M, Shalek AK, Ananthakrishnan AN, Xavier RJ, Regev A, Gupta RM, Lage K, Ardlie KG, Hirschhorn JN, Lander ES, Engreitz JM, Finucane HK Nature genetics 37443254 Nat Genet 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37443254
Multiomic Analysis and CRISPR Perturbation Screens Identify Endothelial Cell Programs and Novel Therapeutic Targets for Coronary Artery Disease. Gupta RM, Schnitzler GR, Fang S, Lee-Kim VS, Barry A Arteriosclerosis, thrombosis, and vascular biology 36994731 Arterioscler Thromb Vasc Biol 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36994731
The Aging Aorta: Are We Only as Old as Our Endothelium? Gupta RM, Plutzky J Arteriosclerosis, thrombosis, and vascular biology 35080899 Arterioscler Thromb Vasc Biol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35080899
Causal Gene Confusion: The Complicated EDN1/PHACTR1 Locus for Coronary Artery Disease. Gupta RM Arteriosclerosis, thrombosis, and vascular biology 35387481 Arterioscler Thromb Vasc Biol 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35387481
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Convergence of coronary artery disease genes onto endothelial cell programs. Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM Nature 38326615 Nature 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38326615
Polygenic prediction of preeclampsia and gestational hypertension. Honigberg MC, Truong B, Khan RR, Xiao B, Bhatta L, Vy HMT, Guerrero RF, Schuermans A, Selvaraj MS, Patel AP, Koyama S, Cho SMJ, Vellarikkal SK, Trinder M, Urbut SM, Gray KJ, Brumpton BM, Patil S, Zöllner S, Antopia MC, Saxena R, Nadkarni GN, Do R, Yan Q, Pe'er I, Verma SS, Gupta RM, Haas DM, Martin HC, van Heel DA, Laisk T, Natarajan P Nature medicine 37248299 Nat Med 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37248299
Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque. Gupta RM, Libby P, Barton M Atherosclerosis 31810569 Atherosclerosis 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31810569
Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease. Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K Communications biology 38216744 Commun Biol 2024 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/38216744
Decoding Vascular Cell Diversity: Single-Cell Approaches to Mechanisms of Vascular Disease. Schwartzman WE, Jiang J, Rao JS, Schnitzler G, Maurya M, Widdup L, Pepin ME, Kang H, Zheng C, Gupta RM Circulation research 41481684 Circ Res 2026 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/41481684
The March of Monocytes in Atherosclerosis: One Cell at a Time. Gupta RM, Lee-Kim VS, Libby P Circulation research 32379573 Circ Res 2020 May 8 https://www.ncbi.nlm.nih.gov/pubmed/32379573
Vagal sensory neurons and gut-brain signaling. Yu CD, Xu QJ, Chang RB Current opinion in neurobiology 32380360 Curr Opin Neurobiol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32380360
A multidimensional coding architecture of the vagal interoceptive system. Zhao Q, Yu CD, Wang R, Xu QJ, Dai Pra R, Zhang L, Chang RB Nature 35296859 Nature 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35296859
Regulation of Cardiac Function by the Autonomic Nervous System. Hafez OA, Chang RB Physiology (Bethesda, Md.) 39585760 Physiology (Bethesda) 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/39585760
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Cardiovascular Brain Circuits. Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht AJR Circulation research 37228235 Circ Res 2023 May 26 https://www.ncbi.nlm.nih.gov/pubmed/37228235
Differential developmental blueprints of organ-intrinsic nervous systems. Hsu IU, Lin Y, Guo Y, Xu QJ, Shao Y, Wang RL, Yin D, Zhao J, Young LH, Zhao H, Zhang L, Chang RB bioRxiv : the preprint server for biology 38168446 bioRxiv 2023 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/38168446
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma. LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T Cancer cell 32707078 Cancer Cell 2020 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/32707078
Functional inference of gene regulation using single-cell multi-omics. Kartha VK, Duarte FM, Hu Y, Ma S, Chew JG, Lareau CA, Earl A, Burkett ZD, Kohlway AS, Lebofsky R, Buenrostro JD Cell genomics 36204155 Cell Genom 2022 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/36204155
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Multiscale footprints reveal the organization of cis-regulatory elements. Hu Y, Horlbeck MA, Zhang R, Ma S, Shrestha R, Kartha VK, Duarte FM, Hock C, Savage RE, Labade A, Kletzien H, Meliki A, Castillo A, Durand NC, Mattei E, Anderson LJ, Tay T, Earl AS, Shoresh N, Epstein CB, Wagers AJ, Buenrostro JD Nature 39843737 Nature 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39843737
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Ma S, Zhang B, LaFave LM, Earl AS, Chiang Z, Hu Y, Ding J, Brack A, Kartha VK, Tay T, Law T, Lareau C, Hsu YC, Regev A, Buenrostro JD Cell 33098772 Cell 2020 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/33098772
Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements. Hu Y, Ma S, Kartha VK, Duarte FM, Horlbeck M, Zhang R, Shrestha R, Labade A, Kletzien H, Meliki A, Castillo A, Durand N, Mattei E, Anderson LJ, Tay T, Earl AS, Shoresh N, Epstein CB, Wagers A, Buenrostro JD bioRxiv : the preprint server for biology 37034577 bioRxiv 2023 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/37034577
scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution. Hingerl JC, Martens LD, Karollus A, Manz T, Buenrostro JD, Theis FJ, Gagneur J bioRxiv : the preprint server for biology 39345504 bioRxiv 2025 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/39345504
A microRNA expression and regulatory element activity atlas of the mouse immune system. Rose SA, Wroblewska A, Dhainaut M, Yoshida H, Shaffer JM, Bektesevic A, Ben-Zvi B, Rhoads A, Kim EY, Yu B, Lavin Y, Merad M, Buenrostro JD, Brown BD, Immunological Genome Consortium Nature immunology 34099919 Nat Immunol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34099919
A transcription factor atlas of directed differentiation. Joung J, Ma S, Tay T, Geiger-Schuller KR, Kirchgatterer PC, Verdine VK, Guo B, Arias-Garcia MA, Allen WE, Singh A, Kuksenko O, Abudayyeh OO, Gootenberg JS, Fu Z, Macrae RK, Buenrostro JD, Regev A, Zhang F Cell 36608654 Cell 2023 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/36608654
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Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome. Clough CA, Pangallo J, Sarchi M, Ilagan JO, North K, Bergantinos R, Stolla MC, Naru J, Nugent P, Kim E, Stirewalt DL, Subramaniam AR, Abdel-Wahab O, Abkowitz JL, Bradley RK, Doulatov S Blood 34861039 Blood 2022 Mar 31 https://www.ncbi.nlm.nih.gov/pubmed/34861039
Understanding Human Oncogene Function and Cooperativity in Myeloid Malignancy Using iPSCs. Sarchi M, Doulatov S Experimental hematology 39674361 Exp Hematol 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39674361
Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells. Wellington R, Cheng X, Campbell CA, Trapnell C, Espin-Palazon R, Hadland B, Doulatov S bioRxiv : the preprint server for biology 39386462 bioRxiv 2024 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/39386462
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes. Hsu J, Reilly A, Hayes BJ, Clough CA, Konnick EQ, Torok-Storb B, Gulsuner S, Wu D, Becker PS, Keel SB, Abkowitz JL, Doulatov S Blood 31010849 Blood 2019 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/31010849
Induced pluripotent stem cell models of myeloid malignancies and clonal evolution. Reilly A, Doulatov S Stem cell research 33592565 Stem Cell Res 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33592565
ATG4A regulates human erythroid maturation and mitochondrial clearance. Stolla MC, Reilly A, Bergantinos R, Stewart S, Thom N, Clough CA, Wellington RC, Stolitenko R, Abkowitz JL, Doulatov S Blood advances 35443024 Blood Adv 2022 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/35443024
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function. Reilly A, Philip Creamer J, Stewart S, Stolla MC, Wang Y, Du J, Wellington R, Busch S, Estey EH, Becker PS, Fang M, Keel SB, Abkowitz JL, Soma LA, Ma J, Duan Z, Doulatov S Cell stem cell 35278369 Cell Stem Cell 2022 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/35278369
Induced pluripotent stem cell line (SDQLCHi041-A) from a male patient with mucopolysaccharidosis type IIIB. Guan J, Tian G, Dong R, Zhang H, Yang X, Li Y, Gai Z, Liu Y Stem cell research 33550137 Stem Cell Res 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33550137
Studying clonal evolution of myeloid malignancies using induced pluripotent stem cells. Doulatov S, Papapetrou EP Current opinion in hematology 33264225 Curr Opin Hematol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33264225
Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells. Wellington R, Cheng X, Dutta S, Campbell CA, Trapnell C, Espin-Palazon R, Hadland B, Doulatov S Stem cell reports 40972587 Stem Cell Reports 2025 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/40972587
Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition. Sarchi M, Clough CA, Crosse EI, Kim J, Baquero Galvis LD, Aydinyan N, Wellington R, Yang F, Gallì A, Creamer JP, Stewart S, Bradley RK, Malcovati L, Doulatov S Blood cancer discovery 38856693 Blood Cancer Discov 2024 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/38856693
R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts. Liu ZS, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken AJ, Bonner EA, Hanson BK, Sarchi M, Takashima K, Zong D, Corral VM, Nguyen E, Yoo J, Chiraphapphaiboon W, Leibson C, McMahon MC, Rai S, Swisher EM, Sachs Z, Chatla S, Stirewalt DL, Deeg HJ, Skorski T, Papapetrou EP, Walter MJ, Graubert TA, Doulatov S, Lee SC, Nguyen HD Cancer research 37967363 Cancer Res 2024 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/37967363
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. Berg DA, Su Y, Jimenez-Cyrus D, Patel A, Huang N, Morizet D, Lee S, Shah R, Ringeling FR, Jain R, Epstein JA, Wu QF, Canzar S, Ming GL, Song H, Bond AM Cell 30929900 Cell 2019 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/30929900
Lineage-specific reorganization of nuclear peripheral heterochromatin and H3K9me2 domains. See K, Lan Y, Rhoades J, Jain R, Smith CL, Epstein JA Development (Cambridge, England) 30723106 Development 2019 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/30723106
H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. Poleshko A, Smith CL, Nguyen SC, Sivaramakrishnan P, Wong KG, Murray JI, Lakadamyali M, Joyce EF, Jain R, Epstein JA eLife 31573510 Elife 2019 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/31573510
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate. Shiraishi K, Shah PP, Morley MP, Loebel C, Santini GT, Katzen J, Basil MC, Lin SM, Planer JD, Cantu E, Jones DL, Nottingham AN, Li S, Cardenas-Diaz FL, Zhou S, Burdick JA, Jain R, Morrisey EE Cell 36870331 Cell 2023 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/36870331
Picking Winners and Losers: Cell Competition in Tissue Development and Homeostasis. Kim W, Jain R Trends in genetics : TIG 32418713 Trends Genet 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32418713
Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression. Gozalo A, Duke A, Lan Y, Pascual-Garcia P, Talamas JA, Nguyen SC, Shah PP, Jain R, Joyce EF, Capelson M Molecular cell 31784359 Mol Cell 2020 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/31784359
An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype. Shah PP, Keough KC, Gjoni K, Santini GT, Abdill RJ, Wickramasinghe NM, Dundes CE, Karnay A, Chen A, Salomon REA, Walsh PJ, Nguyen SC, Whalen S, Joyce EF, Loh KM, Dubois N, Pollard KS, Jain R Genome biology 36691074 Genome Biol 2023 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/36691074
Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors. Smith CL, Lan Y, Jain R, Epstein JA, Poleshko A Science advances 34559565 Sci Adv 2021 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/34559565
A LAMP sequencing approach for high-throughput co-detection of SARS-CoV-2 and influenza virus in human saliva. Warneford-Thomson R, Shah PP, Lundgren P, Lerner J, Morgan J, Davila A, Abella BS, Zaret K, Schug J, Jain R, Thaiss CA, Bonasio R eLife 35532013 Elife 2022 May 9 https://www.ncbi.nlm.nih.gov/pubmed/35532013
Aberrant chromatin organization at the nexus of laminopathy disease pathways. Santini GT, Shah PP, Karnay A, Jain R Nucleus (Austin, Tex.) 36503349 Nucleus 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36503349
Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells. Jiang CL, Goyal Y, Jain N, Wang Q, Truitt RE, Coté AJ, Emert B, Mellis IA, Kiani K, Yang W, Jain R, Raj A Genome biology 35382863 Genome Biol 2022 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/35382863
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina. Kiseleva AA, Cheng YC, Smith CL, Katz RA, Poleshko A Nucleus (Austin, Tex.) 36633363 Nucleus 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/36633363
Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE Proceedings of the National Academy of Sciences of the United States of America 30782824 Proc Natl Acad Sci U S A 2019 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/30782824
A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL Circulation research 31822208 Circ Res 2020 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/31822208
Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R Cell stem cell 33529599 Cell Stem Cell 2021 May 6 https://www.ncbi.nlm.nih.gov/pubmed/33529599
InterLINCing Chromatin Organization and Mechanobiology in Laminopathies. Shah PP, Santini GT, Shen KM, Jain R Current cardiology reports 37052760 Curr Cardiol Rep 2023 May https://www.ncbi.nlm.nih.gov/pubmed/37052760
Nanotherapeutics Engineered to Cross the Blood-Brain Barrier for Advanced Drug Delivery to the Central Nervous System. Kim J, Ahn SI, Kim Y Journal of industrial and engineering chemistry (Seoul, Korea) 31588177 J Ind Eng Chem 2019 May 25 https://www.ncbi.nlm.nih.gov/pubmed/31588177
Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors. Lee Y, Choi JJ, Ahn SI, Lee NH, Han WM, Mohiuddin M, Shin EJ, Wood L, Park KD, Kim Y, Jang YC Advanced functional materials 38053980 Adv Funct Mater 2020 Nov 11 https://www.ncbi.nlm.nih.gov/pubmed/38053980
Polymeric Nanoparticles Controlled by On-Chip Self-Assembly Enhance Cancer Treatment Effectiveness. Jung S, Lee J, Lim J, Suh J, Kim T, Ahn J, Kim WJ, Kim Y Advanced healthcare materials 33073526 Adv Healthc Mater 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33073526
Detecting the functional complexities between high-density lipoprotein mimetics. Sei YJ, Ahn J, Kim T, Shin E, Santiago-Lopez AJ, Jang SS, Jeon NL, Jang YC, Kim Y Biomaterials 29653287 Biomaterials 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29653287
Advanced Human BBB-on-a-Chip: A New Platform for Alzheimer's Disease Studies. Yoon JK, Kim J, Shah Z, Awasthi A, Mahajan A, Kim Y Advanced healthcare materials 34075728 Adv Healthc Mater 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34075728
Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma. Kim J, Dey A, Malhotra A, Liu J, Ahn SI, Sei YJ, Kenney AM, MacDonald TJ, Kim Y Proceedings of the National Academy of Sciences of the United States of America 32934143 Proc Natl Acad Sci U S A 2020 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/32934143
Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance. Lim J, Ching H, Yoon JK, Jeon NL, Kim Y Nano convergence 33846849 Nano Converg 2021 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/33846849
Neuromodulation Approaches for Cardiac Arrhythmias: Recent Advances. Dusi V, Zhu C, Ajijola OA Current cardiology reports 30887264 Curr Cardiol Rep 2019 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/30887264
Single-cell transcriptomic profiling of satellite glial cells in stellate ganglia reveals developmental and functional axial dynamics. van Weperen VYH, Littman RJ, Arneson DV, Contreras J, Yang X, Ajijola OA Glia 33432730 Glia 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33432730
Coronary Sinus Neuropeptide Y Levels and Adverse Outcomes in Patients With Stable Chronic Heart Failure. Ajijola OA, Chatterjee NA, Gonzales MJ, Gornbein J, Liu K, Li D, Paterson DJ, Shivkumar K, Singh JP, Herring N JAMA cardiology 31876927 JAMA Cardiol 2020 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/31876927
3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis. Colbert CM, Shao J, Hollowed JJ, Currier JW, Ajijola OA, Fishbein GA, Duarte-Vogel SM, Dharmakumar R, Hu P, Nguyen KL Journal of cardiovascular translational research 32394352 J Cardiovasc Transl Res 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32394352
A novel metric linking stellate ganglion neuronal population dynamics to cardiopulmonary physiology. Sudarshan KB, Hori Y, Swid MA, Karavos AC, Wooten C, Armour JA, Kember G, Ajijola OA American journal of physiology. Heart and circulatory physiology 34213390 Am J Physiol Heart Circ Physiol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/34213390
Prognostic impact of atrial rhythm and dimension in patients with structural heart disease undergoing cardiac sympathetic denervation for ventricular arrhythmias. Dusi V, Sorg JM, Gornbein J, Gima J, Yanagawa J, Lee JM, Vecerek N, Vaseghi M, Bradfield JS, De Ferrari GM, Shivkumar K, Ajijola OA Heart rhythm 31837474 Heart Rhythm 2020 May https://www.ncbi.nlm.nih.gov/pubmed/31837474
Cardiac afferent signaling partially underlies premature ventricular contraction-induced cardiomyopathy. Hori Y, Temma T, Wooten C, Sobowale C, Chan C, Swid M, Ajijola OA Heart rhythm 33845214 Heart Rhythm 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33845214
Aorticorenal ganglion as a novel target for renal neuromodulation. Hori Y, Temma T, Wooten C, Sobowale C, Tahmasian S, Chan C, Swid MA, Zuckerman JE, Peacock W, Ajijola OA Heart rhythm 34182169 Heart Rhythm 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34182169
Circulating Neuropeptide Y as a Biomarker for Neuromodulation in Atrial Fibrillation. Stavrakis S, Morris L, Takashima AD, Elkholey K, Van Wagoner DR, Ajijola OA JACC. Clinical electrophysiology 33213819 JACC Clin Electrophysiol 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33213819
RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity. Bardsley EN, Davis H, Ajijola OA, Buckler KJ, Ardell JL, Shivkumar K, Paterson DJ Scientific reports 29872217 Sci Rep 2018 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/29872217
Inflammation, oxidative stress, and glial cell activation characterize stellate ganglia from humans with electrical storm. Ajijola OA, Hoover DB, Simerly TM, Brown TC, Yanagawa J, Biniwale RM, Lee JM, Sadeghi A, Khanlou N, Ardell JL, Shivkumar K JCI insight 28931760 JCI Insight 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28931760
Cardiac vanilloid receptor-1 afferent depletion enhances stellate ganglion neuronal activity and efferent sympathetic response to cardiac stress. Yoshie K, Rajendran PS, Massoud L, Kwon O, Tadimeti V, Salavatian S, Ardell JL, Shivkumar K, Ajijola OA American journal of physiology. Heart and circulatory physiology 29351450 Am J Physiol Heart Circ Physiol 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29351450
Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains. Davis H, Bardsley EN, Paterson DJ Scientific data 29944142 Sci Data 2018 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/29944142
Efficacy of Stellate Ganglion Blockade in Managing Electrical Storm: A Systematic Review. Meng L, Tseng CH, Shivkumar K, Ajijola O JACC. Clinical electrophysiology 29270467 JACC Clin Electrophysiol 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/29270467
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A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives. El-Nachef D, Shi K, Beussman KM, Martinez R, Regier MC, Everett GW, Murry CE, Stevens KR, Young JE, Sniadecki NJ, Davis J Stem cell reports 32619493 Stem Cell Reports 2020 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/32619493
A FRESH Take on Resolution in 3D Bioprinting. Corbett DC, Olszewski E, Stevens K Trends in biotechnology 31623960 Trends Biotechnol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31623960
Human Pluripotent Stem Cell-Derived Engineered Tissues: Clinical Considerations. Stevens KR, Murry CE Cell stem cell 29499147 Cell Stem Cell 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29499147
Embryo-scale, single-cell spatial transcriptomics. Srivatsan SR, Regier MC, Barkan E, Franks JM, Packer JS, Grosjean P, Duran M, Saxton S, Ladd JJ, Spielmann M, Lois C, Lampe PD, Shendure J, Stevens KR, Trapnell C Science (New York, N.Y.) 34210887 Science 2021 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/34210887
Author Correction: Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates. Kinstlinger IS, Saxton SH, Calderon GA, Ruiz KV, Yalacki DR, Deme PR, Rosenkrantz JE, Louis-Rosenberg JD, Johansson F, Janson KD, Sazer DW, Panchavati SS, Bissig KD, Stevens KR, Miller JS Nature biomedical engineering 34135476 Nat Biomed Eng 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34135476
Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Grigoryan B, Paulsen SJ, Corbett DC, Sazer DW, Fortin CL, Zaita AJ, Greenfield PT, Calafat NJ, Gounley JP, Ta AH, Johansson F, Randles A, Rosenkrantz JE, Louis-Rosenberg JD, Galie PA, Stevens KR, Miller JS Science (New York, N.Y.) 31048486 Science 2019 May 3 https://www.ncbi.nlm.nih.gov/pubmed/31048486
Spatial presentation of biological molecules to cells by localized diffusive transfer. Regier MC, Olszewski E, Carter CC, Aitchison JD, Kaushansky A, Davis J, Berthier E, Beebe DJ, Stevens KR Lab on a chip 31111131 Lab Chip 2019 Jun 11 https://www.ncbi.nlm.nih.gov/pubmed/31111131
Photopatterned biomolecule immobilization to guide three-dimensional cell fate in natural protein-based hydrogels. Batalov I, Stevens KR, DeForest CA Proceedings of the National Academy of Sciences of the United States of America 33468675 Proc Natl Acad Sci U S A 2021 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/33468675
User-defined morphogen patterning for directing human cell fate stratification. Regier MC, Tokar JJ, Warrick JW, Pabon L, Berthier E, Beebe DJ, Stevens KR Scientific reports 31015521 Sci Rep 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/31015521
Engineered tissue vascularization and engraftment depends on host model. Brady EL, Prado O, Johansson F, Mitchell SN, Martinson AM, Karbassi E, Reinecke H, Murry CE, Davis J, Stevens KR Scientific reports 36737618 Sci Rep 2023 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/36737618
Engineering Heart Morphogenesis. Mandrycky CJ, Williams NP, Batalov I, El-Nachef D, de Bakker BS, Davis J, Kim DH, DeForest CA, Zheng Y, Stevens KR, Sniadecki NJ Trends in biotechnology 32673587 Trends Biotechnol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32673587
The development and characterization of a novel yet simple 3D printed tool to facilitate phantom imaging of photoacoustic contrast agents. Arconada-Alvarez SJ, Lemaster JE, Wang J, Jokerst JV Photoacoustics 28239554 Photoacoustics 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28239554
Optics-Free, Non-Contact Measurements of Fluids, Bubbles, and Particles in Microchannels Using Metallic Nano-Islands on Graphene. Dhong C, Edmunds SJ, Ramírez J, Kayser LV, Chen F, Jokerst JV, Lipomi DJ Nano letters 30024767 Nano Lett 2018 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/30024767
Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements. Lin CY, Chen F, Hariri A, Chen CJ, Wilder-Smith P, Takesh T, Jokerst JV Journal of dental research 28880116 J Dent Res 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28880116
Photoacoustic Imaging of Human Mesenchymal Stem Cells Labeled with Prussian Blue-Poly(l-lysine) Nanocomplexes. Kim T, Lemaster JE, Chen F, Li J, Jokerst JV ACS nano 28759195 ACS Nano 2017 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/28759195
Simultaneous Enhancement of Photoluminescence, MRI Relaxivity, and CT Contrast by Tuning the Interfacial Layer of Lanthanide Heteroepitaxial Nanoparticles. He S, Johnson NJJ, Nguyen Huu VA, Cory E, Huang Y, Sah RL, Jokerst JV, Almutairi A Nano letters 28657755 Nano Lett 2017 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/28657755
Assessment of Respiratory Droplet Transmission During the Ophthalmic Slit-Lamp Exam: A Particle Tracking Analysis. Shah SH, Garg AK, Patel S, Yim W, Jokerst JV, Chao DL American journal of ophthalmology 32980331 Am J Ophthalmol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/32980331
Engineering Plasmonic Nanoparticles for Enhanced Photoacoustic Imaging. Mantri Y, Jokerst JV ACS nano 32806027 ACS Nano 2020 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/32806027
Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions. Lemaster JE, Jeevarathinam AS, Kumar A, Chandrasekar B, Chen F, Jokerst JV ACS applied bio materials 31930189 ACS Appl Bio Mater 2019 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/31930189
A fiber optic photoacoustic sensor for real-time heparin monitoring. Zhou J, Yim W, Zhou J, Jin Z, Xu M, Mantri Y, He T, Cheng Y, Fu L, Wu Z, Hancock T, Penny W, Jokerst JV Biosensors & bioelectronics 34653712 Biosens Bioelectron 2022 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/34653712
Gold Nanorod-Melanin Hybrids for Enhanced and Prolonged Photoacoustic Imaging in the Near-Infrared-II Window. Yim W, Zhou J, Mantri Y, Creyer MN, Moore CA, Jokerst JV ACS applied materials & interfaces 33761255 ACS Appl Mater Interfaces 2021 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/33761255
Enhanced Photoacoustic Detection of Heparin in Whole Blood via Melanin Nanocapsules Carrying Molecular Agents. Yim W, Takemura K, Zhou J, Zhou J, Jin Z, Borum RM, Xu M, Cheng Y, He T, Penny W, Miller BR 3rd, Jokerst JV ACS nano 34962765 ACS Nano 2022 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/34962765
Polyphenol-stabilized coacervates for enzyme-triggered drug delivery. Yim W, Jin Z, Chang YC, Brambila C, Creyer MN, Ling C, He T, Li Y, Retout M, Penny WF, Zhou J, Jokerst JV Nature communications 39181884 Nat Commun 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39181884
Activatable Photoacoustic Probe for Imaging Infection: Gold Nanorod Dissociation In Vivo Reports Bacterial Protease Activity. Retout M, Lepeintre V, Amer L, Yim W, Jokerst JV ACS nano 40116426 ACS Nano 2025 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/40116426
A Gold/Silver Hybrid Nanoparticle for Treatment and Photoacoustic Imaging of Bacterial Infection. Kim T, Zhang Q, Li J, Zhang L, Jokerst JV ACS nano 29746090 ACS Nano 2018 Jun 26 https://www.ncbi.nlm.nih.gov/pubmed/29746090
Silicon Carbide Nanoparticles as a Photoacoustic and Photoluminescent Dual-Imaging Contrast Agent for Long-Term Cell Tracking. Chen F, Zhao ER, Hu T, Shi Y, Sirbuly DJ, Jokerst JV Nanoscale advances 33313479 Nanoscale Adv 2019 https://www.ncbi.nlm.nih.gov/pubmed/33313479
Deep learning improves contrast in low-fluence photoacoustic imaging. Hariri A, Alipour K, Mantri Y, Schulze JP, Jokerst JV Biomedical optics express 32637260 Biomed Opt Express 2020 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/32637260
Dictionary learning technique enhances signal in LED-based photoacoustic imaging. Farnia P, Najafzadeh E, Hariri A, Lavasani SN, Makkiabadi B, Ahmadian A, Jokerst JV Biomedical optics express 32499941 Biomed Opt Express 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32499941
Iodide-doped precious metal nanoparticles: measuring oxidative stress in vivo via photoacoustic imaging. Mantri Y, Davidi B, Lemaster JE, Hariri A, Jokerst JV Nanoscale 32396928 Nanoscale 2020 May 21 https://www.ncbi.nlm.nih.gov/pubmed/32396928
Stereoselective Growth of Small Molecule Patches on Nanoparticles. Zhou J, Creyer MN, Chen A, Yim W, Lafleur RPM, He T, Lin Z, Xu M, Abbasi P, Wu J, Pascal TA, Caruso F, Jokerst JV Journal of the American Chemical Society 34270250 J Am Chem Soc 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34270250
Photoacoustic imaging for monitoring periodontal health: A first human study. Moore C, Bai Y, Hariri A, Sanchez JB, Lin CY, Koka S, Sedghizadeh P, Chen C, Jokerst JV Photoacoustics 30450281 Photoacoustics 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30450281
A Photoacoustic Contrast Agent for miR-21 via NIR Fluorescent Hybridization Chain Reaction. Borum RM, Moore C, Chan SK, Steinmetz NF, Jokerst JV Bioconjugate chemistry 34406744 Bioconjug Chem 2022 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/34406744
The in vivo fate of tobacco mosaic virus nanoparticle theranostic agents modified by the addition of a polydopamine coat. Nkanga CI, Chung YH, Shukla S, Zhou J, Jokerst JV, Steinmetz NF Biomaterials science 34591046 Biomater Sci 2021 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/34591046
Development of a Trimodal Contrast Agent for Acoustic and Magnetic Particle Imaging of Stem Cells. Lemaster JE, Chen F, Kim T, Hariri A, Jokerst JV ACS applied nano materials 33860154 ACS Appl Nano Mater 2018 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/33860154
KN95 and N95 Respirators Retain Filtration Efficiency despite a Loss of Dipole Charge during Decontamination. Yim W, Cheng D, Patel SH, Kou R, Meng YS, Jokerst JV ACS applied materials & interfaces 33253527 ACS Appl Mater Interfaces 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33253527
Motion-compensated noninvasive periodontal health monitoring using handheld and motor-based photoacoustic-ultrasound imaging systems. Mozaffarzadeh M, Moore C, Golmoghani EB, Mantri Y, Hariri A, Jorns A, Fu L, Verweij MD, Orooji M, de Jong N, Jokerst JV Biomedical optics express 33796371 Biomed Opt Express 2021 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/33796371
Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine. Wu D , Zhou J , Creyer MN , Yim W , Chen Z , Messersmith PB , Jokerst JV Chemical Society reviews 33595004 Chem Soc Rev 2021 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/33595004
Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging. Moore C, Jokerst JV Theranostics 31037123 Theranostics 2019 https://www.ncbi.nlm.nih.gov/pubmed/31037123
Noninvasive staging of pressure ulcers using photoacoustic imaging. Hariri A, Chen F, Moore C, Jokerst JV Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 31301258 Wound Repair Regen 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31301258
Photoacoustic Imaging Quantifies Drug Release from Nanocarriers via Redox Chemistry of Dye-Labeled Cargo. Jeevarathinam AS, Lemaster JE, Chen F, Zhao E, Jokerst JV Angewandte Chemie (International ed. in English) 31840357 Angew Chem Int Ed Engl 2020 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/31840357
A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity. Retout M, Amer L, Yim W, Creyer MN, Lam B, Trujillo DF, Potempa J, O'Donoghue AJ, Chen C, Jokerst JV ACS nano 37602819 ACS Nano 2023 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/37602819
Exosome-like silica nanoparticles: a novel ultrasound contrast agent for stem cell imaging. Chen F, Ma M, Wang J, Wang F, Chern SX, Zhao ER, Jhunjhunwala A, Darmadi S, Chen H, Jokerst JV Nanoscale 27924340 Nanoscale 2017 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/27924340
Synchronization of RF Data in Ultrasound Open Platforms (UOPs) for High-Accuracy and High-Resolution Photoacoustic Tomography Using the "Scissors" Programming Method. Fu L, Jin Z, Qi B, Yim W, Wu Z, He T, Jokerst JV IEEE transactions on ultrasonics, ferroelectrics, and frequency control 35377843 IEEE Trans Ultrason Ferroelectr Freq Control 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35377843
Gadolinium Doping Enhances the Photoacoustic Signal of Synthetic Melanin Nanoparticles: A Dual Modality Contrast Agent for Stem Cell Imaging. Lemaster JE, Wang Z, Hariri A, Chen F, Hu Z, Huang Y, Barback CV, Cochran R, Gianneschi NC, Jokerst JV Chemistry of materials : a publication of the American Chemical Society 33859455 Chem Mater 2019 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/33859455
Multispectral Nanoparticle Tracking Analysis for the Real-Time and Label-Free Characterization of Amyloid-β Self-Assembly In Vitro. Moore C, Wing R, Pham T, Jokerst JV Analytical chemistry 32786456 Anal Chem 2020 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/32786456
Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging. Wang J, Hsu SW, Gonzalez-Pech N, Jhunjhunwala A, Chen F, Hariri A, Grassian V, Tao A, Jokerst JV Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems 32863594 Part Part Syst Charact 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/32863594
Assessing the Physiological Relevance of Cough Simulators for Respiratory Droplet Dispersion. Patel SH, Yim W, Garg AK, Shah SH, Jokerst JV, Chao DL Journal of clinical medicine 32957639 J Clin Med 2020 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/32957639
Multifunctional nanomedicine with silica: Role of silica in nanoparticles for theranostic, imaging, and drug monitoring. Chen F, Hableel G, Zhao ER, Jokerst JV Journal of colloid and interface science 29510868 J Colloid Interface Sci 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/29510868
Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents. Xie Y, Wang J, Wang J, Hu Z, Hariri A, Tu N, Krug KA, Burkart MD, Gianneschi NC, Jokerst JV, Rinehart JD Journal of materials chemistry. B 31389967 J Mater Chem B 2019 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/31389967
Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system. Hariri A, Zhao E, Jeevarathinam AS, Lemaster J, Zhang J, Jokerst JV Scientific reports 31388020 Sci Rep 2019 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/31388020
Stem Cell Tracking with Nanoparticle-Based Ultrasound Contrast Agents. Chen F, Jokerst JV Methods in molecular biology (Clifton, N.J.) 32112386 Methods Mol Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32112386
Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging. Moore C, Chen F, Wang J, Jokerst JV Advanced drug delivery reviews 31295522 Adv Drug Deliv Rev 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/31295522
The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging. Hariri A, Lemaster J, Wang J, Jeevarathinam AS, Chao DL, Jokerst JV Photoacoustics 29234601 Photoacoustics 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29234601
Cellular toxicity of silicon carbide nanomaterials as a function of morphology. Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV Biomaterials 29980075 Biomaterials 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29980075
A Nanoscale Tool for Photoacoustic-Based Measurements of Clotting Time and Therapeutic Drug Monitoring of Heparin. Wang J, Chen F, Arconada-Alvarez SJ, Hartanto J, Yap LP, Park R, Wang F, Vorobyova I, Dagliyan G, Conti PS, Jokerst JV Nano letters 27668964 Nano Lett 2016 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/27668964
Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions. Zhou J, Penna M, Lin Z, Han Y, Lafleur RPM, Qu Y, Richardson JJ, Yarovsky I, Jokerst JV, Caruso F Angewandte Chemie (International ed. in English) 34258845 Angew Chem Int Ed Engl 2021 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/34258845
Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity. Moore C, Borum RM, Mantri Y, Xu M, Fajtová P, O'Donoghue AJ, Jokerst JV ACS sensors 34038103 ACS Sens 2021 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/34038103
A Wearable Colorimetric Dosimeter to Monitor Sunlight Exposure. Wang J, Jeevarathinam AS, Jhunjhunwala A, Ren H, Lemaster J, Luo Y, Fenning DP, Fullerton EE, Jokerst JV Advanced materials technologies 33928184 Adv Mater Technol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/33928184
Versatile Polymer Nanocapsules via Redox Competition. Zhou J, Xu M, Jin Z, Borum RM, Avakyan N, Cheng Y, Yim W, He T, Zhou J, Wu Z, Mantri Y, Jokerst JV Angewandte Chemie (International ed. in English) 34580967 Angew Chem Int Ed Engl 2021 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/34580967
In vivo photoacoustic imaging of chorioretinal oxygen gradients. Hariri A, Wang J, Kim Y, Jhunjhunwala A, Chao DL, Jokerst JV Journal of biomedical optics 29524321 J Biomed Opt 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29524321
A Mechanistic Investigation of Methylene Blue and Heparin Interactions and Their Photoacoustic Enhancement. Wang J, Jeevarathinam AS, Humphries K, Jhunjhunwala A, Chen F, Hariri A, Miller BR 3rd, Jokerst JV Bioconjugate chemistry 30281976 Bioconjug Chem 2018 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/30281976
Gold nanoparticles to enhance ophthalmic imaging. Chen F , Si P , de la Zerda A , Jokerst JV , Myung D Biomaterials science 33057463 Biomater Sci 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/33057463
Photoacoustic imaging with fiber optic technology: A review. Zhou J, Jokerst JV Photoacoustics 33163358 Photoacoustics 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33163358
Hybridizing clinical translatability with enzyme-free DNA signal amplifiers: recent advances in nucleic acid detection and imaging. Borum RM , Jokerst JV Biomaterials science 32734995 Biomater Sci 2021 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/32734995
Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles. Kang J, Kim D, Wang J, Han Y, Zuidema JM, Hariri A, Park JH, Jokerst JV, Sailor MJ Advanced materials (Deerfield Beach, Fla.) 29782671 Adv Mater 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29782671
Switchable Photoacoustic Intensity of Methylene Blue via Sodium Dodecyl Sulfate Micellization. Wang J, Lin CY, Moore C, Jhunjhunwala A, Jokerst JV Langmuir : the ACS journal of surfaces and colloids 29232146 Langmuir 2018 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/29232146
Smart-Dust-Nanorice for Enhancement of Endogenous Raman Signal, Contrast in Photoacoustic Imaging, and T2-Shortening in Magnetic Resonance Imaging. Pohling C, Campbell JL, Larson TA, Van de Sompel D, Levi J, Bachmann MH, Bohndiek SE, Jokerst JV, Gambhir SS Small (Weinheim an der Bergstrasse, Germany) 29635739 Small 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29635739
A cellulose-based photoacoustic sensor to measure heparin concentration and activity in human blood samples. Jeevarathinam AS, Pai N, Huang K, Hariri A, Wang J, Bai Y, Wang L, Hancock T, Keys S, Penny W, Jokerst JV Biosensors & bioelectronics 30602265 Biosens Bioelectron 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30602265
Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window. Yim W, Borum RM, Zhou J, Mantri Y, Wu Z, Zhou J, Jin Z, Creyer M, Jokerst JV Nanotheranostics 34976582 Nanotheranostics 2022 https://www.ncbi.nlm.nih.gov/pubmed/34976582
Peptide-Induced Fractal Assembly of Silver Nanoparticles for Visual Detection of Disease Biomarkers. Retout M, Mantri Y, Jin Z, Zhou J, Noël G, Donovan B, Yim W, Jokerst JV ACS nano 35377141 ACS Nano 2022 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/35377141
Supramolecular Loading of DNA Hydrogels with Dye-Drug Conjugates for Real-Time Photoacoustic Monitoring of Chemotherapy. Borum RM, Moore C, Mantri Y, Xu M, Jokerst JV Advanced science (Weinheim, Baden-Wurttemberg, Germany) 36403233 Adv Sci (Weinh) 2022 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/36403233
Organosilica Nanoparticles with an Intrinsic Secondary Amine: An Efficient and Reusable Adsorbent for Dyes. Chen F, Zhao E, Kim T, Wang J, Hableel G, Reardon PJT, Ananthakrishna SJ, Wang T, Arconada-Alvarez S, Knowles JC, Jokerst JV ACS applied materials & interfaces 28422482 ACS Appl Mater Interfaces 2017 May 10 https://www.ncbi.nlm.nih.gov/pubmed/28422482
Increasing the Efficacy of Stem Cell Therapy via Triple-Function Inorganic Nanoparticles. Chen F, Zhao ER, Hableel G, Hu T, Kim T, Li J, Gonzalez-Pech NI, Cheng DJ, Lemaster JE, Xie Y, Grassian VH, Sen GL, Jokerst JV ACS nano 31188564 ACS Nano 2019 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/31188564
A Photoacoustic-Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis. Moore C, Cheng Y, Tjokro N, Zhang B, Kerr M, Hayati M, Chang KCJ, Shah N, Chen C, Jokerst JV Angewandte Chemie (International ed. in English) 35583940 Angew Chem Int Ed Engl 2022 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/35583940
Uncovering a Cryptic Site of Malaria Pathogenesis: Models to Study Interactions Between Plasmodium and the Bone Marrow. Feldman TP, Egan ES Frontiers in cellular and infection microbiology 35719356 Front Cell Infect Microbiol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35719356
A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans. Nguetse CN, Purington N, Ebel ER, Shakya B, Tetard M, Kremsner PG, Velavan TP, Egan ES Proceedings of the National Academy of Sciences of the United States of America 32265284 Proc Natl Acad Sci U S A 2020 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/32265284
Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion. Baro B, Kim CY, Lin C, Kongsomboonvech AK, Tetard M, Peterson NA, Salinas ND, Tolia NH, Egan ES Blood 37832027 Blood 2023 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/37832027
Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites. Shakya B, Patel SD, Tani Y, Egan ES eLife 34028351 Elife 2021 May 24 https://www.ncbi.nlm.nih.gov/pubmed/34028351
Cryo-electron tomography with mixed-scale dense neural networks reveals key steps in deployment of Toxoplasma invasion machinery. Segev-Zarko LA, Dahlberg PD, Sun SY, Pelt DM, Kim CY, Egan ES, Sethian JA, Chiu W, Boothroyd JC PNAS nexus 36329726 PNAS Nexus 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36329726
Beyond Hemoglobin: Screening for Malaria Host Factors. Egan ES Trends in genetics : TIG 29249333 Trends Genet 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29249333
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT Communications biology 30271928 Commun Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30271928
Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy. Ebel ER, Uricchio LH, Petrov DA, Egan ES Trends in parasitology 35065882 Trends Parasitol 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35065882
Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum. Sun SY, Segev-Zarko L-a, Pintilie GD, Kim CY, Staggers SR, Schmid MF, Egan ES, Chiu W, Boothroyd JC mBio 38456679 mBio 2024 Apr 10 https://www.ncbi.nlm.nih.gov/pubmed/38456679
Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes. Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W Hepatology (Baltimore, Md.) 31188495 Hepatology 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31188495
Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins. Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ RNA (New York, N.Y.) 31439808 RNA 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31439808
Understanding and repurposing CRISPR-mediated alternative splicing. Smith JL, Mou H, Xue W Genome biology 30400804 Genome Biol 2018 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/30400804
All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ Genome biology 30231914 Genome Biol 2018 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/30231914
In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency. Song CQ, Wang D, Jiang T, O'Connor K, Tang Q, Cai L, Li X, Weng Z, Yin H, Gao G, Mueller C, Flotte TR, Xue W Human gene therapy 29597895 Hum Gene Ther 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29597895
Deletion and replacement of long genomic sequences using prime editing. Jiang T, Zhang XO, Weng Z, Xue W Nature biotechnology 34650270 Nat Biotechnol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34650270
AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys. Liang SQ, Navia AW, Ramseier M, Zhou X, Martinez M, Lee C, Zhou C, Wu J, Xie J, Su Q, Wang D, Flotte TR, Anderson DG, Tarantal AF, Shalek AK, Gao G, Xue W Human gene therapy 38767512 Hum Gene Ther 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38767512
Template-jumping prime editing enables large insertion and exon rewriting in vivo. Zheng C, Liu B, Dong X, Gaston N, Sontheimer EJ, Xue W Nature communications 37291100 Nat Commun 2023 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/37291100
Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing. Li B, Manan RS, Liang SQ, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D Nature biotechnology 36997680 Nat Biotechnol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/36997680
CRISPR-Cas-related technologies in basic and translational liver research. Song CQ, Xue W Nature reviews. Gastroenterology & hepatology 29443117 Nat Rev Gastroenterol Hepatol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29443117
A split prime editor with untethered reverse transcriptase and circular RNA template. Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodríguez TC, Liang SQ, Xue W, Sontheimer EJ Nature biotechnology 35379962 Nat Biotechnol 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35379962
Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Jiang T, Sánchez-Rivera FJ, Soto-Feliciano YM, Yang Q, Song CQ, Bhuatkar A, Haynes CM, Hemann MT, Xue W Hepatology (Baltimore, Md.) 33336367 Hepatology 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33336367
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G Nature biotechnology 30102296 Nat Biotechnol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30102296
Adenine base editing in an adult mouse model of tyrosinaemia. Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W Nature biomedical engineering 31740768 Nat Biomed Eng 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31740768
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG Nature chemical biology 29377001 Nat Chem Biol 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29377001
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, Watts JK, Xue W, Sontheimer EJ Nature biotechnology 37709915 Nat Biotechnol 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/37709915
CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W Genome biology 28615073 Genome Biol 2017 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/28615073
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG Nature biotechnology 29131148 Nat Biotechnol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29131148
The temporal landscape of recursive splicing during Pol II transcription elongation in human cells. Zhang XO, Fu Y, Mou H, Xue W, Weng Z PLoS genetics 30148885 PLoS Genet 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30148885
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Pérez JA, Sontheimer EJ Molecular cell 30581144 Mol Cell 2019 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/30581144
YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells. Smith JL, Rodríguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Weng Z, Sontheimer EJ, Xue W Hepatology (Baltimore, Md.) 32452550 Hepatology 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/32452550
Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases. Wu SS, Li QC, Yin CQ, Xue W, Song CQ Theranostics 32292501 Theranostics 2020 https://www.ncbi.nlm.nih.gov/pubmed/32292501
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D Jr, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W Gastroenterology 27956228 Gastroenterology 2017 Apr https://www.ncbi.nlm.nih.gov/pubmed/27956228
Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Mou H, Moore J, Malonia SK, Li Y, Ozata DM, Hough S, Song CQ, Smith JL, Fischer A, Weng Z, Green MR, Xue W Proceedings of the National Academy of Sciences of the United States of America 28320962 Proc Natl Acad Sci U S A 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28320962
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Liu P, Liang SQ, Zheng C, Mintzer E, Zhao YG, Ponnienselvan K, Mir A, Sontheimer EJ, Gao G, Flotte TR, Wolfe SA, Xue W Nature communications 33837189 Nat Commun 2021 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/33837189
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ Nature communications 34725353 Nat Commun 2021 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/34725353
Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes. Rodríguez TC, Kwan SY, Smith JL, Dadafarin S, Wu CH, Sontheimer EJ, Xue W Hepatology (Baltimore, Md.) 35932276 Hepatology 2023 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/35932276
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, Liu DR, Xue W Nature communications 32332735 Nat Commun 2020 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/32332735
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Liang SQ, Liu P, Smith JL, Mintzer E, Maitland S, Dong X, Yang Q, Lee J, Haynes CM, Zhu LJ, Watts JK, Sontheimer EJ, Wolfe SA, Xue W Nature communications 35064134 Nat Commun 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/35064134
A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver. Zheng C, Liang SQ, Liu B, Liu P, Kwan SY, Wolfe SA, Xue W Molecular therapy : the journal of the American Society of Gene Therapy 34998953 Mol Ther 2022 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/34998953
AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Liang SQ, Walkey CJ, Martinez AE, Su Q, Dickinson ME, Wang D, Lagor WR, Heaney JD, Gao G, Xue W Molecular therapy : the journal of the American Society of Gene Therapy 34695545 Mol Ther 2022 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/34695545
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. Liang SQ, Liu P, Ponnienselvan K, Suresh S, Chen Z, Kramme C, Chatterjee P, Zhu LJ, Sontheimer EJ, Xue W, Wolfe SA Nature methods 37156841 Nat Methods 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37156841
CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling. Mou H, Ozata DM, Smith JL, Sheel A, Kwan SY, Hough S, Kucukural A, Kennedy Z, Cao Y, Xue W Genome medicine 30987660 Genome Med 2019 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/30987660
Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction. Dale BL, Pandey AK, Chen Y, Smart CD, Laroumanie F, Ao M, Xiao L, Dikalova AE, Dikalov SI, Elijovich F, Foss JD, Barbaro NR, Van Beusecum JP, Deger SM, Alsouqi A, Itani HA, Norlander AE, Alexander MR, Zhao S, Ikizler TA, Algood HMS, Madhur MS JCI insight 31013256 JCI Insight 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/31013256
Human monocyte transcriptional profiling identifies IL-18 receptor accessory protein and lactoferrin as novel immune targets in hypertension. Alexander MR, Norlander AE, Elijovich F, Atreya RV, Gaye A, Gnecco JS, Laffer CL, Galindo CL, Madhur MS British journal of pharmacology 29774543 Br J Pharmacol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/29774543
Evidence for a Causal Role of the SH2B3-β(2)M Axis in Blood Pressure Regulation. Keefe JA, Hwang SJ, Huan T, Mendelson M, Yao C, Courchesne P, Saleh MA, Madhur MS, Levy D Hypertension (Dallas, Tex. : 1979) 30624993 Hypertension 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30624993
A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Laroumanie F, Du L, Harrison DG, Madhur MS JCI insight 28679951 JCI Insight 2017 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/28679951
The immunology of hypertension. Norlander AE, Madhur MS, Harrison DG The Journal of experimental medicine 29247045 J Exp Med 2018 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/29247045
Interleukin 17A: Key Player in the Pathogenesis of Hypertension and a Potential Therapeutic Target. Davis GK, Fehrenbach DJ, Madhur MS Current hypertension reports 33666761 Curr Hypertens Rep 2021 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/33666761
Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic? Madhur MS, Elijovich F, Alexander MR, Pitzer A, Ishimwe J, Van Beusecum JP, Patrick DM, Smart CD, Kleyman TR, Kingery J, Peck RN, Laffer CL, Kirabo A Circulation research 33793336 Circ Res 2021 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/33793336
Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease. Gonzalez AL, Dungan MM, Smart CD, Madhur MS, Doran AC Antioxidants & redox signaling 37125445 Antioxid Redox Signal 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37125445
From Rags to Riches: Moving Beyond RAG1 in Studies of Hypertension. Madhur MS, Kirabo A, Guzik TJ, Harrison DG Hypertension (Dallas, Tex. : 1979) 32078385 Hypertension 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32078385
Adaptive immune cells in calcific aortic valve disease. Raddatz MA, Madhur MS, Merryman WD American journal of physiology. Heart and circulatory physiology 31050556 Am J Physiol Heart Circ Physiol 2019 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/31050556
Status of Early-Career Academic Cardiology: A Global Perspective. Tong CW, Madhur MS, Rzeszut AK, Abdalla M, Abudayyeh I, Alexanderson E, Buber J, Feldman DN, Gopinathannair R, Hira RS, Kates AM, Kessler T, Leung S, Raj SR, Spatz ES, Turner MB, Valente AM, West K, Sivaram CA, Hill JA, Mann DL, Freeman AM Journal of the American College of Cardiology 29073958 J Am Coll Cardiol 2017 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/29073958
Targeting IL-33/ST2 Signaling Alters Cardiac Structure and Function in Hypertensive Heart Disease. Wassenaar JW, Smart CD, Fehrenbach DJ, Agrawal V, Dungan MM, Fortune NL, Zhong L, Hemnes AR, Peebles RS Jr, Miller FJ Jr, Doran AC, Madhur MS JACC. Basic to translational science 39958476 JACC Basic Transl Sci 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39958476
Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice. Chen Y, Dale BL, Alexander MR, Xiao L, Ao M, Pandey AK, Smart CD, Davis GK, Madhur MS Cardiovascular research 32609312 Cardiovasc Res 2021 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/32609312
Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species. Alexander MR, Schoeder CT, Brown JA, Smart CD, Moth C, Wikswo JP, Capra JA, Meiler J, Chen W, Madhur MS FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33015868 FASEB J 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33015868
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, Nicklin SA, Marian AJ, Nosalski R, Murray EC, Guzik B, Berry C, Touyz RM, Kreutz R, Wang DW, Bhella D, Sagliocco O, Crea F, Thomson EC, McInnes IB Cardiovascular research 32352535 Cardiovasc Res 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32352535
Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K(+)] during K(+)-deficient diet. McFarlin BE, Chen Y, Priver TS, Ralph DL, Mercado A, Gamba G, Madhur MS, McDonough AA American journal of physiology. Cell physiology 32845718 Am J Physiol Cell Physiol 2020 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/32845718
LNK deficiency promotes acute aortic dissection and rupture. Laroumanie F, Korneva A, Bersi MR, Alexander MR, Xiao L, Zhong X, Van Beusecum JP, Chen Y, Saleh MA, McMaster WG, Gavulic KA, Dale BL, Zhao S, Guo Y, Shyr Y, Perrien DS, Cox NJ, Curci JA, Humphrey JD, Madhur MS JCI insight 30333305 JCI Insight 2018 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/30333305
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure. Smart CD, Fehrenbach DJ, Wassenaar JW, Agrawal V, Fortune NL, Dixon DD, Cottam MA, Hasty AH, Hemnes AR, Doran AC, Gupta DK, Madhur MS Cardiovascular research 37314125 Cardiovasc Res 2023 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/37314125
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage. Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS Circulation research 36169218 Circ Res 2022 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/36169218
Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis. Yi S, Allen SD, Liu YG, Ouyang BZ, Li X, Augsornworawat P, Thorp EB, Scott EA ACS nano 27935698 ACS Nano 2016 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/27935698
Sustained micellar delivery via inducible transitions in nanostructure morphology. Karabin NB, Allen S, Kwon HK, Bobbala S, Firlar E, Shokuhfar T, Shull KR, Scott EA Nature communications 29434200 Nat Commun 2018 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/29434200
Targeted Delivery of Cell Softening Micelles to Schlemm's Canal Endothelial Cells for Treatment of Glaucoma. Stack T, Vincent M, Vahabikashi A, Li G, Perkumas KM, Stamer WD, Johnson M, Scott E Small (Weinheim an der Bergstrasse, Germany) 33015961 Small 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33015961
Employment of targeted nanoparticles for imaging of cellular processes in cardiovascular disease. Modak M, Frey MA, Yi S, Liu Y, Scott EA Current opinion in biotechnology 32682272 Curr Opin Biotechnol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32682272
Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone-sulfone bonding. Du F, Qiao B, Nguyen TD, Vincent MP, Bobbala S, Yi S, Lescott C, Dravid VP, Olvera de la Cruz M, Scott EA Nature communications 32994414 Nat Commun 2020 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/32994414
Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity. Bobbala S, Allen SD, Yi S, Vincent M, Frey M, Karabin NB, Scott EA Nanoscale 32090217 Nanoscale 2020 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/32090217
An Injectable Hydrogel Platform for Sustained Delivery of Anti-inflammatory Nanocarriers and Induction of Regulatory T Cells in Atherosclerosis. Yi S, Karabin NB, Zhu J, Bobbala S, Lyu H, Li S, Liu Y, Frey M, Vincent M, Scott EA Frontiers in bioengineering and biotechnology 32582667 Front Bioeng Biotechnol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32582667
Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection. Li X, Yi S, Scariot DB, Martinez SJ, Falk BA, Olson CL, Romano PS, Scott EA, Engman DM JCI insight 33986194 JCI Insight 2021 May 10 https://www.ncbi.nlm.nih.gov/pubmed/33986194
Pi-stacking Enhances Stability, Scalability of Formation, Control over Flexibility and Circulation Time of Polymeric Filaments. Li S, Bobbala S, Vincent MP, Modak M, Liu Y, Scott EA Advanced nanobiomed research 34870281 Adv Nanobiomed Res 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34870281
Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres. Bobbala S , Allen SD , Scott EA Nanoscale 29255814 Nanoscale 2018 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/29255814
Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence. Du F, Liu YG, Scott EA Cellular and molecular bioengineering 28989540 Cell Mol Bioeng 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28989540
Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis. Allen S, Liu YG, Scott E Regenerative engineering and translational medicine 27135051 Regen Eng Transl Med 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/27135051
Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells. Yi S, Kim SY, Vincent MP, Yuk SA, Bobbala S, Du F, Scott EA iScience 35769884 iScience 2022 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/35769884
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation. Allen S, Vincent M, Scott E Journal of visualized experiments : JoVE 30148497 J Vis Exp 2018 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/30148497
Super-Resolution Imaging of Self-Assembled Nanocarriers Using Quantitative Spectroscopic Analysis for Cluster Extraction. Davis JL, Zhang Y, Yi S, Du F, Song KH, Scott EA, Sun C, Zhang HF Langmuir : the ACS journal of surfaces and colloids 32069413 Langmuir 2020 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/32069413
Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets. Vincent MP, Bobbala S, Karabin NB, Frey M, Liu Y, Navidzadeh JO, Stack T, Scott EA Nature communications 33510170 Nat Commun 2021 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/33510170
The Combination of Morphology and Surface Chemistry Defines the Immunological Identity of Nanocarriers in Human Blood. Vincent MP, Karabin NB, Allen SD, Bobbala S, Frey MA, Yi S, Yang Y, Scott EA Advanced therapeutics 34485684 Adv Ther (Weinh) 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34485684
Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy. Vincent MP, Stack T, Vahabikashi A, Li G, Perkumas KM, Ren R, Gong H, Stamer WD, Johnson M, Scott EA ACS applied materials & interfaces 34232612 ACS Appl Mater Interfaces 2021 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/34232612
Just add water: hydratable, morphologically diverse nanocarrier powders for targeted delivery. Bobbala S, Vincent MP, Scott EA Nanoscale 34160529 Nanoscale 2021 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/34160529
Sequential intracellular release of water-soluble cargos from Shell-crosslinked polymersomes. Du F, Bobbala S, Yi S, Scott EA Journal of controlled release : official journal of the Controlled Release Society 29601932 J Control Release 2018 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/29601932
On the advancement of polymeric bicontinuous nanospheres toward biomedical applications. Allen SD, Bobbala S, Karabin NB, Scott EA Nanoscale horizons 32254084 Nanoscale Horiz 2019 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/32254084
Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers. Shang S, Kats D, Cao L, Morgun E, Velluto D, He Y, Xu Q, Wang CR, Scott EA Frontiers in immunology 30538700 Front Immunol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30538700
Celastrol-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis. Allen SD , Liu YG , Kim T , Bobbala S , Yi S , Zhang X , Choi J , Scott EA Biomaterials science 30601470 Biomater Sci 2019 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/30601470
Minimizing Molecular Misidentification in Imaging Low-Abundance Protein Interactions Using Spectroscopic Single-Molecule Localization Microscopy. Zhang Y, Wang G, Huang P, Sun E, Kweon J, Li Q, Zhe J, Ying LL, Zhang HF Analytical chemistry 36165784 Anal Chem 2022 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/36165784
Influences of nanocarrier morphology on therapeutic immunomodulation. Frey M, Bobbala S, Karabin N, Scott E Nanomedicine (London, England) 30084296 Nanomedicine (Lond) 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/30084296
Dual Treatment of Chronic Chagasic Cardiomyopathy and Parasitic Burden via Combination Nanotherapy. Staneviciute A, B Scariot D, Liu YG, Qian Y, Sharma S, Mbaye EHA, Almunif S, Engman DM, Scott EA ACS nano 40279477 ACS Nano 2025 May 6 https://www.ncbi.nlm.nih.gov/pubmed/40279477
Efficacy of benznidazole delivery during Chagas disease nanotherapy is dependent on the nanocarrier morphology. Scariot DB, Staneviciute A, Machado RRB, Yuk SA, Liu YG, Sharma S, Almunif S, Arona Mbaye EH, Nakamura CV, Engman DM, Scott EA Biomaterials 40318604 Biomaterials 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/40318604
Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair. Zhang S, Yeap XY, DeBerge M, Naresh NK, Wang K, Jiang Z, Wilcox JE, White SM, Morrow JP, Burridge PW, Procissi D, Scott EA, Frazier W, Thorp EB JACC. Basic to translational science 28920097 JACC Basic Transl Sci 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28920097
Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation. Allen S, Osorio O, Liu YG, Scott E Journal of controlled release : official journal of the Controlled Release Society 28736263 J Control Release 2017 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/28736263
Surface engineered polymersomes for enhanced modulation of dendritic cells during cardiovascular immunotherapy. Yi S, Zhang X, Sangji H, Liu Y, Allen SD, Xiao B, Bobbala S, Braverman CL, Cai L, Hecker PI, DeBerge M, Thorp EB, Temel RE, Stupp SI, Scott EA Advanced functional materials 34335131 Adv Funct Mater 2019 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/34335131
Enhancing subcutaneous injection and target tissue accumulation of nanoparticles via co-administration with macropinocytosis inhibitory nanoparticles (MiNP). Stack T, Liu Y, Frey M, Bobbala S, Vincent M, Scott E Nanoscale horizons 33884386 Nanoscale Horiz 2021 May 1 https://www.ncbi.nlm.nih.gov/pubmed/33884386
Modulation of Schlemm's canal endothelial cell stiffness via latrunculin loaded block copolymer micelles. Stack T, Vahabikashi A, Johnson M, Scott E Journal of biomedical materials research. Part A 29468812 J Biomed Mater Res A 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29468812
Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy. Vincent MP, Navidzadeh JO, Bobbala S, Scott EA Cancer cell 35148814 Cancer Cell 2022 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/35148814
Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability. Burke JA, Zhang X, Bobbala S, Frey MA, Bohorquez Fuentes C, Freire Haddad H, Allen SD, Richardson RAK, Ameer GA, Scott EA Nature nanotechnology 35039683 Nat Nanotechnol 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35039683
Outcomes of Catheter Ablation of Ventricular Tachycardia Based on Etiology in Nonischemic Heart Disease: An International Ventricular Tachycardia Ablation Center Collaborative Study. Vaseghi M, Hu TY, Tung R, Vergara P, Frankel DS, Di Biase L, Tedrow UB, Gornbein JA, Yu R, Mathuria N, Nakahara S, Tzou WS, Sauer WH, Burkhardt JD, Tholakanahalli VN, Dickfeld TM, Weiss JP, Bunch TJ, Reddy M, Callans DJ, Lakkireddy DR, Natale A, Marchlinski FE, Stevenson WG, Della Bella P, Shivkumar K JACC. Clinical electrophysiology 30236386 JACC Clin Electrophysiol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30236386
Update on prevention and treatment of sudden cardiac arrest. Krokhaleva Y, Vaseghi M Trends in cardiovascular medicine 30449537 Trends Cardiovasc Med 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/30449537
Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death. Huang WA, Boyle NG, Vaseghi M Cardiac electrophysiology clinics 29173409 Card Electrophysiol Clin 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/29173409
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, Dagres N, Di Toro D, Eckhardt LL, Ellenbogen K, Hardy C, Ikeda T, Jaswal A, Kaufman E, Krahn A, Kusano K, Kutyifa V, Lim HS, Lip GYH, Nava-Townsend S, Pak HN, Rodríguez Diez G, Sauer W, Saxena A, Svendsen JH, Vanegas D, Vaseghi M, Wilde A, Bunch TJ, ESC Scientific Document Group, Buxton AE, Calvimontes G, Chao TF, Eckardt L, Estner H, Gillis AM, Isa R, Kautzner J, Maury P, Moss JD, Nam GB, Olshansky B, Pava Molano LF, Pimentel M, Prabhu M, Tzou WS, Sommer P, Swampillai J, Vidal A, Deneke T, Hindricks G, Leclercq C Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 32538434 Europace 2020 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/32538434
Looking Beyond Storm: Forecast Remains Gloomy for Clustered Ventricular Arrhythmias. Khakpour H, Vaseghi M JACC. Clinical electrophysiology 32192685 JACC Clin Electrophysiol 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32192685
Sex and Race/Ethnicity Differences in Atrial Fibrillation. Volgman AS, Bairey Merz CN, Benjamin EJ, Curtis AB, Fang MC, Lindley KJ, Pepine CJ, Vaseghi M, Waldo AL, Wenger NK, Russo AM Journal of the American College of Cardiology 31779796 J Am Coll Cardiol 2019 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/31779796
Cardiac sympathetic denervation for intractable ventricular arrhythmias in Chagas disease. Saenz LC, Corrales FM, Bautista W, Traina M, Meymandi S, Rodriguez DA, Tellez LJ, Vaseghi M, Garcia F, Shivkumar K, Bradfield JS Heart rhythm 26969783 Heart Rhythm 2016 Jul https://www.ncbi.nlm.nih.gov/pubmed/26969783
Cardiac neuroanatomy - Imaging nerves to define functional control. Hanna P, Rajendran PS, Ajijola OA, Vaseghi M, Andrew Armour J, Ardell JL, Shivkumar K Autonomic neuroscience : basic & clinical 28802636 Auton Neurosci 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28802636
Thoracic Epidural Anesthesia Can Be Effective for the Short-Term Management of Ventricular Tachycardia Storm. Do DH, Bradfield J, Ajijola OA, Vaseghi M, Le J, Rahman S, Mahajan A, Nogami A, Boyle NG, Shivkumar K Journal of the American Heart Association 29079570 J Am Heart Assoc 2017 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/29079570
Editorial Commentary: Chronic obstructive pulmonary disease and sudden cardiac death: Cause and effect or simply an association? Hoffman J, Vaseghi M Trends in cardiovascular medicine 27238054 Trends Cardiovasc Med 2016 Oct https://www.ncbi.nlm.nih.gov/pubmed/27238054
Relationship between sinus rhythm late activation zones and critical sites for scar-related ventricular tachycardia: systematic analysis of isochronal late activation mapping. Irie T, Yu R, Bradfield JS, Vaseghi M, Buch EF, Ajijola O, Macias C, Fujimura O, Mandapati R, Boyle NG, Shivkumar K, Tung R Circulation. Arrhythmia and electrophysiology 25740836 Circ Arrhythm Electrophysiol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25740836
Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction. Yamaguchi N, Yamakawa K, Rajendran PS, Takamiya T, Vaseghi M Heart rhythm 29530832 Heart Rhythm 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/29530832
Microstructural Infarct Border Zone Remodeling in the Post-infarct Swine Heart Measured by Diffusion Tensor MRI. Kung GL, Vaseghi M, Gahm JK, Shevtsov J, Garfinkel A, Shivkumar K, Ennis DB Frontiers in physiology 30246802 Front Physiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30246802
Cardiac sympathetic activation circumvents high-dose beta blocker therapy in part through release of neuropeptide Y. Hoang JD, Salavatian S, Yamaguchi N, Swid MA, David H, Vaseghi M JCI insight 32493842 JCI Insight 2020 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/32493842
Arrhythmic Risk Profile and Outcomes of Patients Undergoing Cardiac Sympathetic Denervation for Recurrent Monomorphic Ventricular Tachycardia After Ablation. Dusi V, Gornbein J, Do DH, Sorg JM, Khakpour H, Krokhaleva Y, Ajijola OA, Macias C, Bradfield JS, Buch E, Fujimura OA, Boyle NG, Yanagawa J, Lee JM, Shivkumar K, Vaseghi M Journal of the American Heart Association 33441022 J Am Heart Assoc 2021 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/33441022
Ventricular Tachycardia in Dilated Cardiomyopathy: Is it Time for Genetic Testing in All Patients? Nguyen HL, Vaseghi M JACC. Clinical electrophysiology 32972545 JACC Clin Electrophysiol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32972545
Arrhythmogenic Right Ventricular Cardiomyopathy: Electroarchitecture of the Substrate. Watanabe A, Seki A, Fishbein MC, Shivkumar K, Vaseghi M HeartRhythm case reports 26955520 HeartRhythm Case Rep 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26955520
Cardiac sympathetic innervation via middle cervical and stellate ganglia and antiarrhythmic mechanism of bilateral stellectomy. Irie T, Yamakawa K, Hamon D, Nakamura K, Shivkumar K, Vaseghi M American journal of physiology. Heart and circulatory physiology 28011590 Am J Physiol Heart Circ Physiol 2017 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/28011590
Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction. Vaseghi M, Salavatian S, Rajendran PS, Yagishita D, Woodward WR, Hamon D, Yamakawa K, Irie T, Habecker BA, Shivkumar K JCI insight 28814663 JCI Insight 2017 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/28814663
The autonomic nervous system and ventricular arrhythmias in myocardial infarction and heart failure. Wu P, Vaseghi M Pacing and clinical electrophysiology : PACE 31823401 Pacing Clin Electrophysiol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31823401
Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Shivkumar K, Ajijola OA, Anand I, Armour JA, Chen PS, Esler M, De Ferrari GM, Fishbein MC, Goldberger JJ, Harper RM, Joyner MJ, Khalsa SS, Kumar R, Lane R, Mahajan A, Po S, Schwartz PJ, Somers VK, Valderrabano M, Vaseghi M, Zipes DP The Journal of physiology 27114333 J Physiol 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27114333
Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK Scientific reports 26935567 Sci Rep 2016 Mar 3 https://www.ncbi.nlm.nih.gov/pubmed/26935567
Direct Cardiac Reprogramming: Progress and Promise. Engel JL, Ardehali R Stem cells international 29731772 Stem Cells Int 2018 https://www.ncbi.nlm.nih.gov/pubmed/29731772
In Vivo Clonal Analysis of Cardiomyocytes. Nguyen NB, Fernandez GE, Ding Y, Hsiai T, Ardehali R Methods in molecular biology (Clifton, N.J.) 32857378 Methods Mol Biol 2021 https://www.ncbi.nlm.nih.gov/pubmed/32857378
Harnessing the versatility of PLGA nanoparticles for targeted Cre-mediated recombination. Nguyen NB, Chen CH, Zhang Y, Zhao P, Wu BM, Ardehali R Nanomedicine : nanotechnology, biology, and medicine 31026512 Nanomedicine 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31026512
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R Nature communications 29467410 Nat Commun 2018 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/29467410
Cardiac fibrosis: potential therapeutic targets. Park S, Nguyen NB, Pezhouman A, Ardehali R Translational research : the journal of laboratory and clinical medicine 30930180 Transl Res 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/30930180
Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. He L, Nguyen NB, Ardehali R, Zhou B Circulation 32687441 Circulation 2020 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/32687441
Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure. Park S, Ranjbarvaziri S, Zhao P, Ardehali R JACC. Basic to translational science 32478206 JACC Basic Transl Sci 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32478206
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R Circulation 29950403 Circulation 2018 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/29950403
Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts. Ranjbarvaziri S, Park S, Nguyen NB, Gilmore WB, Zhao P, Ardehali R Genesis (New York, N.Y. : 2000) 28589709 Genesis 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28589709
HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1. Liu J, Li Y, Lin B, Sheng Y, Yang L Developmental cell 29112854 Dev Cell 2017 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/29112854
Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L Disease models & mechanisms 25791035 Dis Model Mech 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25791035
Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC, Rasmusson RL, London B, Salama G Journal of molecular and cellular cardiology 25644533 J Mol Cell Cardiol 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25644533
Genome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells. Liu J, Liu S, Gao H, Han L, Chu X, Sheng Y, Shou W, Wang Y, Liu Y, Wan J, Yang L Genome biology 32646524 Genome Biol 2020 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/32646524
Comparative transcriptomic analysis of multiple cardiovascular fates from embryonic stem cells predicts novel regulators in human cardiogenesis. Li Y, Lin B, Yang L Scientific reports 25997157 Sci Rep 2015 May 21 https://www.ncbi.nlm.nih.gov/pubmed/25997157
HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1. Liu J, Li Y, Lin B, Sheng Y, Yang L Developmental cell 28829943 Dev Cell 2017 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/28829943
Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues. Paek J, Park SE, Lu Q, Park KT, Cho M, Oh JM, Kwon KW, Yi YS, Song JW, Edelstein HI, Ishibashi J, Yang W, Myerson JW, Kiseleva RY, Aprelev P, Hood ED, Stambolian D, Seale P, Muzykantov VR, Huh D ACS nano 31194909 ACS Nano 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31194909
In Vitro Granuloma Models of Tuberculosis: Potential and Challenges. Elkington P, Lerm M, Kapoor N, Mahon R, Pienaar E, Huh D, Kaushal D, Schlesinger LS The Journal of infectious diseases 30929010 J Infect Dis 2019 May 24 https://www.ncbi.nlm.nih.gov/pubmed/30929010
Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier. Blundell C, Yi YS, Ma L, Tess ER, Farrell MJ, Georgescu A, Aleksunes LM, Huh D Advanced healthcare materials 29121458 Adv Healthc Mater 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29121458
Geometric engineering of organoid culture for enhanced organogenesis in a dish. Park SE, Kang S, Paek J, Georgescu A, Chang J, Yi AY, Wilkins BJ, Karakasheva TA, Hamilton KE, Huh DD Nature methods 36280722 Nat Methods 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36280722
A microengineered model of RBC transfusion-induced pulmonary vascular injury. Seo J, Conegliano D, Farrell M, Cho M, Ding X, Seykora T, Qing D, Mangalmurti NS, Huh D Scientific reports 28611413 Sci Rep 2017 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/28611413
Native extracellular matrix-derived semipermeable, optically transparent, and inexpensive membrane inserts for microfluidic cell culture. Mondrinos MJ, Yi YS, Wu NK, Ding X, Huh D Lab on a chip 28809418 Lab Chip 2017 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/28809418
A microengineered pathophysiological model of early-stage breast cancer. Choi Y, Hyun E, Seo J, Blundell C, Kim HC, Lee E, Lee SH, Moon A, Moon WK, Huh D Lab on a chip 26158500 Lab Chip 2015 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/26158500
Polydopamine-Based Interfacial Engineering of Extracellular Matrix Hydrogels for the Construction and Long-Term Maintenance of Living Three-Dimensional Tissues. Park SE, Georgescu A, Oh JM, Kwon KW, Huh D ACS applied materials & interfaces 31199616 ACS Appl Mater Interfaces 2019 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/31199616
Placenta-on-a-chip: a novel platform to study the biology of the human placenta. Lee JS, Romero R, Han YM, Kim HC, Kim CJ, Hong JS, Huh D The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 26075842 J Matern Fetal Neonatal Med 2016 https://www.ncbi.nlm.nih.gov/pubmed/26075842
Soft robotic constrictor for in vitro modeling of dynamic tissue compression. Paek J, Song JW, Ban E, Morimitsu Y, Osuji CO, Shenoy VB, Huh DD Scientific reports 34389738 Sci Rep 2021 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/34389738
A Human Vascular Injury-on-a-Chip Model of Hemostasis. Poventud-Fuentes I, Kwon KW, Seo J, Tomaiuolo M, Stalker TJ, Brass LF, Huh D Small (Weinheim an der Bergstrasse, Germany) 33150735 Small 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33150735
Multiscale reverse engineering of the human ocular surface. Seo J, Byun WY, Alisafaei F, Georgescu A, Yi YS, Massaro-Giordano M, Shenoy VB, Lee V, Bunya VY, Huh D Nature medicine 31384041 Nat Med 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31384041
Organoids-on-a-chip. Park SE, Georgescu A, Huh D Science (New York, N.Y.) 31171693 Science 2019 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/31171693
A bioinspired microfluidic model of liquid plug-induced mechanical airway injury. Song JW, Paek J, Park KT, Seo J, Huh D Biomicrofluidics 29887935 Biomicrofluidics 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29887935
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip. Georgescu A, Oved JH, Galarraga JH, Cantrell T, Mehta S, Dulmovits BM, Olson TS, Fattahi P, Wang A, Candarlioglu PL, Muvaffak A, Kim MM, Aydin SA, Seo J, Diffenderfer ES, Lynch A, Worthen GS, Huh DD Cell stem cell 39642865 Cell Stem Cell 2024 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/39642865
Organs-on-chips at the frontiers of drug discovery. Esch EW, Bahinski A, Huh D Nature reviews. Drug discovery 25792263 Nat Rev Drug Discov 2015 Apr https://www.ncbi.nlm.nih.gov/pubmed/25792263
A microphysiological model of the human placental barrier. Blundell C, Tess ER, Schanzer AS, Coutifaris C, Su EJ, Parry S, Huh D Lab on a chip 27229450 Lab Chip 2016 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/27229450
Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue. Mondrinos MJ, Alisafaei F, Yi AY, Ahmadzadeh H, Lee I, Blundell C, Seo J, Osborn M, Jeon TJ, Kim SM, Shenoy VB, Huh D Science advances 33712463 Sci Adv 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33712463
Muc5b is required for airway defence. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM Nature 24317696 Nature 2014 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/24317696
Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir. Leiva-Juarez MM, Kirkpatrick CT, Gilbert BE, Scott B, Tuvim MJ, Dickey BF, Evans SE, Markesich D European journal of pharmacology 29066417 Eur J Pharmacol 2018 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/29066417
Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation. Czopik A, Yuan X, Evans SE, Eltzschig HK Anesthesiology 34046661 Anesthesiology 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/34046661
Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming. Wang Y, Kulkarni VV, Pantaleón García J, Leiva-Juárez MM, Goldblatt DL, Gulraiz F, Chen J, Donepudi SR, Lorenzi PL, Wang H, Wong LJ, Tuvim MJ, Evans SE bioRxiv : the preprint server for biology 36711510 bioRxiv 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36711510
The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival. Wang Y, Kulkarni VV, PantaleónGarcía J, Longmire MK, Lethier M, Cusack S, Evans SE JCI insight 39352770 JCI Insight 2024 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/39352770
Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia. Kulkarni VV, Wang Y, Pantaleon Garcia J, Evans SE American journal of respiratory cell and molecular biology 36826841 Am J Respir Cell Mol Biol 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/36826841
Fungal Pneumonia in Patients with Hematologic Malignancy and Hematopoietic Stem Cell Transplantation. Young AY, Leiva Juarez MM, Evans SE Clinics in chest medicine 28797490 Clin Chest Med 2017 Sep https://www.ncbi.nlm.nih.gov/pubmed/28797490
Pneumonia in the neutropenic cancer patient. Evans SE, Ost DE Current opinion in pulmonary medicine 25784246 Curr Opin Pulm Med 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25784246
Toll-like receptor-2/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs. Drake MG, Evans SE, Dickey BF, Fryer AD, Jacoby DB American journal of respiratory cell and molecular biology 23449736 Am J Respir Cell Mol Biol 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23449736
Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands. Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF Frontiers in pharmacology 24567720 Front Pharmacol 2014 https://www.ncbi.nlm.nih.gov/pubmed/24567720
Epithelial immunomodulation by aerosolized Toll-like receptor agonists prevents allergic inflammation in airway mucosa in mice. Goldblatt DL, Valverde Ha G, Wali S, Kulkarni VV, Longmire MK, Jaramillo AM, Chittuluru RP, Fouts A, Martinez-Moczygemba M, Lei JT, Huston DP, Tuvim MJ, Dickey BF, Evans SE Frontiers in pharmacology 36105216 Front Pharmacol 2022 https://www.ncbi.nlm.nih.gov/pubmed/36105216
Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections. Ware HH, Kulkarni VV, Wang Y, Pantaleón García J, Leiva Juarez M, Kirkpatrick CT, Wali S, Syed S, Kontoyiannis AD, Sikkema WKA, Tour JM, Evans SE PloS one 30794556 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/30794556
MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT JCI insight 30944250 JCI Insight 2019 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/30944250
Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases. Smith AM, Harper N, Meunier JA, Branum AP, Jimenez F, Pandranki L, Carrillo A, Dela Cruz CS, Restrepo MI, Maselli DJ, Rather CG, Heisser AH, Ramirez DA, He W, Clark RA, Andrews CP, Evans SE, Pugh JA, Zhang N, Lee GC, Moreira AG, Segal LN, Ramirez RM, Jacobs RL, Manoharan MS, Okulicz JF, Ahuja SK The Journal of allergy and clinical immunology 33493557 J Allergy Clin Immunol 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33493557
Lung epithelial cells are essential effectors of inducible resistance to pneumonia. Cleaver JO, You D, Michaud DR, Pruneda FA, Juarez MM, Zhang J, Weill PM, Adachi R, Gong L, Moghaddam SJ, Poynter ME, Tuvim MJ, Evans SE Mucosal immunology 23632328 Mucosal Immunol 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23632328
Inducible epithelial resistance protects mice against leukemia-associated pneumonia. Leiva-Juárez MM, Ware HH, Kulkarni VV, Zweidler-McKay PA, Tuvim MJ, Evans SE Blood 27317793 Blood 2016 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/27317793
Bacterial Pneumonia in Patients with Cancer: Novel Risk Factors and Management. Wong JL, Evans SE Clinics in chest medicine 28477638 Clin Chest Med 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28477638
Selective Modulation of the Pulmonary Innate Immune Response Does Not Change Lung Microbiota in Healthy Mice. Pantaleón García J, Hinkle KJ, Falkowski NR, Evans SE, Dickson RP American journal of respiratory and critical care medicine 34153197 Am J Respir Crit Care Med 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34153197
Editorial: Purinergic Signaling and Inflammation. Yuan X, Ferrari D, Mills T, Wang Y, Czopik A, Doursout MF, Evans SE, Idzko M, Eltzschig HK Frontiers in immunology 34093597 Front Immunol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34093597
Future Research Directions in Pneumonia. NHLBI Working Group Report. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP American journal of respiratory and critical care medicine 29546996 Am J Respir Crit Care Med 2018 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/29546996
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo. Covés-Datson EM, King SR, Legendre M, Gupta A, Chan SM, Gitlin E, Kulkarni VV, Pantaleón García J, Smee DF, Lipka E, Evans SE, Tarbet EB, Ono A, Markovitz DM Proceedings of the National Academy of Sciences of the United States of America 31932446 Proc Natl Acad Sci U S A 2020 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/31932446
Minimizing caging effects in murine lung microbiome studies. Pantaleón García J, Dickson RP, Evans SE American journal of physiology. Lung cellular and molecular physiology 35944140 Am J Physiol Lung Cell Mol Physiol 2022 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/35944140
Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response. Xia X, Mai J, Xu R, Perez JET, Guevara ML, Shen Q, Mu C, Tung HY, Corry DB, Evans SE, Liu X, Ferrari M, Zhang Z, Li XC, Wang RF, Shen H Cell reports 25937283 Cell Rep 2015 May 12 https://www.ncbi.nlm.nih.gov/pubmed/25937283
The development and plasticity of alveolar type 1 cells. Yang J, Hernandez BJ, Martinez Alanis D, Narvaez del Pilar O, Vila-Ellis L, Akiyama H, Evans SE, Ostrin EJ, Chen J Development (Cambridge, England) 26586225 Development 2016 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/26586225
Viral Pneumonia in Patients with Hematologic Malignancy or Hematopoietic Stem Cell Transplantation. Vakil E, Evans SE Clinics in chest medicine 28159165 Clin Chest Med 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28159165
Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. Goldblatt DL, Flores JR, Valverde Ha G, Jaramillo AM, Tkachman S, Kirkpatrick CT, Wali S, Hernandez B, Ost DE, Scott BL, Chen J, Evans SE, Tuvim MJ, Dickey BF British journal of pharmacology 31968123 Br J Pharmacol 2020 May https://www.ncbi.nlm.nih.gov/pubmed/31968123
Immune Modulation to Improve Survival of Viral Pneumonia in Mice. Wali S, Flores JR, Jaramillo AM, Goldblatt DL, Pantaleón García J, Tuvim MJ, Dickey BF, Evans SE American journal of respiratory cell and molecular biology 32853024 Am J Respir Cell Mol Biol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32853024
Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections. Kirkpatrick CT, Wang Y, Leiva Juarez MM, Shivshankar P, Pantaleón García J, Plumer AK, Kulkarni VV, Ware HH, Gulraiz F, Chavez Cavasos MA, Martinez Zayas G, Wali S, Rice AP, Liu H, Tour JM, Sikkema WKA, Cruz Solbes AS, Youker KA, Tuvim MJ, Dickey BF, Evans SE mBio 29764948 mBio 2018 May 15 https://www.ncbi.nlm.nih.gov/pubmed/29764948
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Automated and Interpretable Patient ECG Profiles for Disease Detection, Tracking, and Discovery. Tison GH, Zhang J, Delling FN, Deo RC Circulation. Cardiovascular quality and outcomes 31525078 Circ Cardiovasc Qual Outcomes 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31525078
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ECM protein nanofibers and nanostructures engineered using surface-initiated assembly. Szymanski JM, Jallerat Q, Feinberg AW Journal of visualized experiments : JoVE 24799041 J Vis Exp 2014 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/24799041
Shrink Wrapping Cells in a Defined Extracellular Matrix to Modulate the Chemo-Mechanical Microenvironment. Palchesko RN, Szymanski JM, Sahu A, Feinberg AW Cellular and molecular bioengineering 25530816 Cell Mol Bioeng 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25530816
Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels. Hinton TJ, Jallerat Q, Palchesko RN, Park JH, Grodzicki MS, Shue HJ, Ramadan MH, Hudson AR, Feinberg AW Science advances 26601312 Sci Adv 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26601312
Engineering Aligned Skeletal Muscle Tissue Using Decellularized Plant-Derived Scaffolds. Cheng YW, Shiwarski DJ, Ball RL, Whitehead KA, Feinberg AW ACS biomaterials science & engineering 33463300 ACS Biomater Sci Eng 2020 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33463300
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3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding. Hinton TJ, Hudson A, Pusch K, Lee A, Feinberg AW ACS biomaterials science & engineering 27747289 ACS Biomater Sci Eng 2016 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/27747289
Stretch-dependent changes in molecular conformation in fibronectin nanofibers. Szymanski JM, Sevcik EN, Zhang K, Feinberg AW Biomaterials science 28612067 Biomater Sci 2017 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/28612067
Engineering aligned human cardiac muscle using developmentally inspired fibronectin micropatterns. Batalov I, Jallerat Q, Kim S, Bliley J, Feinberg AW Scientific reports 34075068 Sci Rep 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/34075068
Extracellular Matrix Structure and Composition in the Early Four-Chambered Embryonic Heart. Jallerat Q, Feinberg AW Cells 31991580 Cells 2020 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/31991580
Large volume syringe pump extruder for desktop 3D printers. Pusch K, Hinton TJ, Feinberg AW HardwareX 30498799 HardwareX 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/30498799
3D bioprinting of collagen to rebuild components of the human heart. Lee A, Hudson AR, Shiwarski DJ, Tashman JW, Hinton TJ, Yerneni S, Bliley JM, Campbell PG, Feinberg AW Science (New York, N.Y.) 31371612 Science 2019 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/31371612
Understanding the Role of ECM Protein Composition and Geometric Micropatterning for Engineering Human Skeletal Muscle. Duffy RM, Sun Y, Feinberg AW Annals of biomedical engineering 26983843 Ann Biomed Eng 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/26983843
Patterning on Topography for Generation of Cell Culture Substrates with Independent Nanoscale Control of Chemical and Topographical Extracellular Matrix Cues. Sevcik EN, Szymanski JM, Jallerat Q, Feinberg AW Current protocols in cell biology 28627752 Curr Protoc Cell Biol 2017 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/28627752
In vitro expansion of corneal endothelial cells on biomimetic substrates. Palchesko RN, Lathrop KL, Funderburgh JL, Feinberg AW Scientific reports 25609008 Sci Rep 2015 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/25609008
Fabrication of freestanding alginate microfibers and microstructures for tissue engineering applications. Szymanski JM, Feinberg AW Biofabrication 24695323 Biofabrication 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24695323
Engineered Basement Membranes for Regenerating the Corneal Endothelium. Palchesko RN, Funderburgh JL, Feinberg AW Advanced healthcare materials 27723276 Adv Healthc Mater 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27723276
Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype. Bliley JM, Vermeer MCSC, Duffy RM, Batalov I, Kramer D, Tashman JW, Shiwarski DJ, Lee A, Teplenin AS, Volkers L, Coffin B, Hoes MF, Kalmykov A, Palchesko RN, Sun Y, Jongbloed JDH, Bomer N, de Boer RA, Suurmeijer AJH, Pijnappels DA, Bolling MC, van der Meer P, Feinberg AW Science translational medicine 34290054 Sci Transl Med 2021 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/34290054
Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue. Shiwarski DJ, Tashman JW, Tsamis A, Bliley JM, Blundon MA, Aranda-Michel E, Jallerat Q, Szymanski JM, McCartney BM, Feinberg AW Nature communications 33208732 Nat Commun 2020 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/33208732
Cryopreserved cell-laden alginate microgel bioink for 3D bioprinting of living tissues. Jeon O, Bin Lee Y, Hinton TJ, Feinberg AW, Alsberg E Materials today. Chemistry 30778400 Mater Today Chem 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30778400
Measuring the Poisson's Ratio of Fibronectin Using Engineered Nanofibers. Szymanski JM, Zhang K, Feinberg AW Scientific reports 29042643 Sci Rep 2017 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/29042643
Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces. Sun Y, Jallerat Q, Szymanski JM, Feinberg AW Nature methods 25506720 Nat Methods 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25506720
Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling. Liu AP Biophysical journal 27456131 Biophys J 2016 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/27456131
Mechanically activated artificial cell by using microfluidics. Ho KK, Lee LM, Liu AP Scientific reports 27610921 Sci Rep 2016 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/27610921
Simultaneous monitoring of transcription and translation in mammalian cell-free expression in bulk and in cell-sized droplets. Wang S, Majumder S, Emery NJ, Liu AP Synthetic biology (Oxford, England) 30003145 Synth Biol (Oxf) 2018 https://www.ncbi.nlm.nih.gov/pubmed/30003145
Protein aggregation with poly(vinyl) alcohol surfactant reduces double emulsion-encapsulated mammalian cell-free expression. Ho KK, Lee JW, Durand G, Majumder S, Liu AP PloS one 28358875 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/28358875
The Application of Micropipette Aspiration in Molecular Mechanics of Single Cells. Lee LM, Liu AP Journal of nanotechnology in engineering and medicine 26155329 J Nanotechnol Eng Med 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/26155329
Bottom-up synthetic biology: modular design for making artificial platelets. Majumder S, Liu AP Physical biology 29091050 Phys Biol 2017 Dec 6 https://www.ncbi.nlm.nih.gov/pubmed/29091050
Development of an advanced microfluidic micropipette aspiration device for single cell mechanics studies. Lee LM, Lee JW, Chase D, Gebrezgiabhier D, Liu AP Biomicrofluidics 27703591 Biomicrofluidics 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27703591
The rise of bottom-up synthetic biology and cell-free biology. Liu AP Physical biology 31018188 Phys Biol 2019 May 7 https://www.ncbi.nlm.nih.gov/pubmed/31018188
Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions. Shao Y, Tan X, Novitski R, Muqaddam M, List P, Williamson L, Fu J, Liu AP The Review of scientific instruments 24289415 Rev Sci Instrum 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24289415
Multiplex detection of homo- and heterodimerization of g protein-coupled receptors by proximity biotinylation. Steel E, Murray VL, Liu AP PloS one 24691126 PLoS One 2014 https://www.ncbi.nlm.nih.gov/pubmed/24691126
Advanced Microfluidic Device Designed for Cyclic Compression of Single Adherent Cells. Ho KKY, Wang YL, Wu J, Liu AP Frontiers in bioengineering and biotechnology 30386779 Front Bioeng Biotechnol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30386779
Synergistic and non-specific nucleic acid production by T7 RNA polymerase and Bsu DNA polymerase catalyzed by single-stranded polynucleotides. Emery NJ, Majumder S, Liu AP Synthetic and systems biotechnology 29900426 Synth Syst Biotechnol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29900426
Lipid bilayer vesicle generation using microfluidic jetting. Coyne CW, Patel K, Heureaux J, Stachowiak J, Fletcher DA, Liu AP Journal of visualized experiments : JoVE 24637415 J Vis Exp 2014 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/24637415
Cofactoring and dimerization of proteinase-activated receptors. Lin H, Liu AP, Smith TH, Trejo J Pharmacological reviews 24064459 Pharmacol Rev 2013 https://www.ncbi.nlm.nih.gov/pubmed/24064459
A microfluidic pipette array for mechanophenotyping of cancer cells and mechanical gating of mechanosensitive channels. Lee LM, Liu AP Lab on a chip 25361042 Lab Chip 2015 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/25361042
Activation of a bacterial mechanosensitive channel in mammalian cells by cytoskeletal stress. Heureaux J, Chen D, Murray VL, Deng CX, Liu AP Cellular and molecular bioengineering 25606062 Cell Mol Bioeng 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/25606062
Engineering artificial cells by combining HeLa-based cell-free expression and ultrathin double emulsion template. Ho KK, Murray VL, Liu AP Methods in cell biology 25997354 Methods Cell Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25997354
Cell-free compartmentalized protein synthesis inside double emulsion templated liposomes with in vitro synthesized and assembled ribosomes. Caschera F, Lee JW, Ho KK, Liu AP, Jewett MC Chemical communications (Cambridge, England) 27019994 Chem Commun (Camb) 2016 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/27019994
Cell-sized mechanosensitive and biosensing compartment programmed with DNA. Majumder S, Garamella J, Wang YL, DeNies M, Noireaux V, Liu AP Chemical communications (Cambridge, England) 28524182 Chem Commun (Camb) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28524182
Acidic pH increases airway surface liquid viscosity in cystic fibrosis. Tang XX, Ostedgaard LS, Hoegger MJ, Moninger TO, Karp PH, McMenimen JD, Choudhury B, Varki A, Stoltz DA, Welsh MJ The Journal of clinical investigation 26808501 J Clin Invest 2016 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/26808501
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Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs. Hoegger MJ, Awadalla M, Namati E, Itani OA, Fischer AJ, Tucker AJ, Adam RJ, McLennan G, Hoffman EA, Stoltz DA, Welsh MJ Proceedings of the National Academy of Sciences of the United States of America 24474805 Proc Natl Acad Sci U S A 2014 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/24474805
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Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis. Diwakar A, Adam RJ, Michalski AS, Tamegnon MM, Fischer AJ, Launspach JL, Horan RA, Kao SC, Chaloner K, Meyerholz DK, Stoltz DA The Laryngoscope 25827636 Laryngoscope 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/25827636
Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans. Meyerholz DK, Lambertz AM, Reznikov LR, Ofori-Amanfo GK, Karp PH, McCray PB Jr, Welsh MJ, Stoltz DA Toxicologic pathology 26511846 Toxicol Pathol 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26511846
Gel-forming mucins form distinct morphologic structures in airways. Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ Proceedings of the National Academy of Sciences of the United States of America 28607090 Proc Natl Acad Sci U S A 2017 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/28607090
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DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance. Zhou N, Choi J, Grothusen G, Kim BJ, Ren D, Cao Z, Liu Y, Li Q, Inamdar A, Beer T, Tang HY, Perkey E, Maillard I, Bonasio R, Shi J, Ruella M, Wan L, Busino L Blood 37235754 Blood 2023 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/37235754
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Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape. Song L, Li Q, Xia L, Sahay AE, Qiu Q, Li Y, Li H, Sasaki K, Susztak K, Wu H, Wan L Nature communications 39009564 Nat Commun 2024 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/39009564
The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers. Eckhardt BV, Richter HJ, Rondeel I, Renduchintala K, Mattiroli F, Ramani V bioRxiv : the preprint server for biology 41000940 bioRxiv 2025 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/41000940
Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription. Parast S, Wang S, Iwanaszko M, He Y, Olgun DG, Gold S, Zeidner JM, Aoi Y, Howard BC, Thakur WR, Ramani V, Shilatifard A Molecular cell 41418754 Mol Cell 2025 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/41418754
The single-molecule accessibility landscape of newly replicated mammalian chromatin. Ostrowski MS, Yang MG, McNally CP, Abdulhay NJ, Wang S, Renduchintala K, Irkliyenko I, Biran A, Chew BTL, Midha AD, Wong EV, Sandoval J, Jain IH, Groth A, Nora EP, Goodarzi H, Ramani V Cell 39549698 Cell 2025 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/39549698
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A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies. Freie B, Carroll PA, Varnum-Finney BJ, Ramsey EL, Ramani V, Bernstein I, Eisenman RN Genes & development 38565249 Genes Dev 2024 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/38565249
ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers. Moore C, Wong E, Kaur U, Chio US, Zhou Z, Ostrowski M, Wu K, Irkliyenko I, Wang S, Ramani V, Narlikar GJ bioRxiv : the preprint server for biology 39314305 bioRxiv 2024 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/39314305
HMGB1 restores a dynamic chromatin environment in the presence of linker histone by deforming nucleosomal DNA. Saunders HS, Chio US, Moore CM, Ramani V, Cheng Y, Narlikar GJ bioRxiv : the preprint server for biology 39229246 bioRxiv 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39229246
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A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies. Freie B, Carroll PA, Varnum-Finney BJ, Ramani V, Bernstein I, Eisenman RN bioRxiv : the preprint server for biology 37961183 bioRxiv 2023 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/37961183
Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Abdulhay NJ, Hsieh LJ, McNally CP, Ostrowski MS, Moore CM, Ketavarapu M, Kasinathan S, Nanda AS, Wu K, Chio US, Zhou Z, Goodarzi H, Narlikar GJ, Ramani V Nature structural & molecular biology 37696956 Nat Struct Mol Biol 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37696956
Direct transposition of native DNA for sensitive multimodal single-molecule sequencing. Nanda AS, Wu K, Irkliyenko I, Woo B, Ostrowski MS, Clugston AS, Sayles LC, Xu L, Satpathy AT, Nguyen HG, Alejandro Sweet-Cordero E, Goodarzi H, Kasinathan S, Ramani V Nature genetics 38724748 Nat Genet 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38724748
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes. Moore C, Wong E, Kaur U, Chio US, Zhou Z, Ostrowski M, Wu K, Irkliyenko I, Wang S, Ramani V, Narlikar GJ Science (New York, N.Y.) 41037607 Science 2025 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/41037607
The Long Noncoding RNA PRANCR Is Associated with Alternative Splicing of Fibronectin-1 in Keratinocytes. Otten ABC, Amarbayar O, Cai P, Cheng B, Qu K, Sun BK The Journal of investigative dermatology 36906126 J Invest Dermatol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/36906126
The role of enhancers in psoriasis and atopic dermatitis. Sui JY, Eichenfield DZ, Sun BK The British journal of dermatology 37658835 Br J Dermatol 2023 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/37658835
Alternative mRNA splicing events and regulators in epidermal differentiation. Takashima S, Sun W, Otten ABC, Cai P, Peng SI, Tong E, Bui J, Mai M, Amarbayar O, Cheng B, Odango RJ, Li Z, Qu K, Sun BK Cell reports 38402585 Cell Rep 2024 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/38402585
Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons. Klompe SE, Jaber N, Beh LY, Mohabir JT, Bernheim A, Sternberg SH Molecular cell 35051352 Mol Cell 2022 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/35051352
Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Meers C, Le HC, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Tang S, Sternberg SH Nature 37758954 Nature 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37758954
Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases. Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH bioRxiv : the preprint server for biology 36993517 bioRxiv 2023 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/36993517
Selective TnsC recruitment enhances the fidelity of RNA-guided transposition. Hoffmann FT, Kim M, Beh LY, Wang J, Vo PLH, Gelsinger DR, George JT, Acree C, Mohabir JT, Fernández IS, Sternberg SH Nature 36002573 Nature 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36002573
Novel recombinases for large DNA insertions. Lampe GD, Sternberg SH Nature biotechnology 36424492 Nat Biotechnol 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36424492
Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases. Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH Nature biotechnology 36991112 Nat Biotechnol 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/36991112
Bacterial genome engineering using CRISPR RNA-guided transposases. Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang H, Sternberg SH bioRxiv : the preprint server for biology 36993567 bioRxiv 2023 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/36993567
Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C, Park JU, Kong M, Wiegand T, Pignot YL, Kellogg EH, Greene EC, Sternberg SH bioRxiv : the preprint server for biology 37503092 bioRxiv 2023 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/37503092
Bacterial genome engineering using CRISPR-associated transposases. Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang HH, Sternberg SH Nature protocols 38216671 Nat Protoc 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38216671
Genome editing with retroelements. Tang S, Sternberg SH Science (New York, N.Y.) 37883564 Science 2023 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/37883564
Antagonistic conflict between transposon-encoded introns and guide RNAs. Žedaveinytė R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH Science (New York, N.Y.) 38991068 Science 2024 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/38991068
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH Nature microbiology 39747689 Nat Microbiol 2025 Jan https://www.ncbi.nlm.nih.gov/pubmed/39747689
TnpB homologues exapted from transposons are RNA-guided transcription factors. Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH Nature 38926585 Nature 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38926585
De novo gene synthesis by an antiviral reverse transcriptase. Tang S, Conte V, Zhang DJ, Žedaveinytė R, Lampe GD, Wiegand T, Tang LC, Wang M, Walker MWG, George JT, Berchowitz LE, Jovanovic M, Sternberg SH Science (New York, N.Y.) 39116258 Science 2024 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/39116258
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase. Witte IP, Lampe GD, Eitzinger S, Miller SM, Berríos KN, McElroy AN, King RT, Stringham OG, Gelsinger DR, Vo PLH, Chen AT, Tolar J, Osborn MJ, Sternberg SH, Liu DR Science (New York, N.Y.) 40373119 Science 2025 May 15 https://www.ncbi.nlm.nih.gov/pubmed/40373119
Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens. Ronda C, Perdue T, Schwanz L, Rivera Gelsinger D, Brockmann L, Kaufman A, Huang Y, Sternberg SH, Wang HH Nature biomedical engineering 40681864 Nat Biomed Eng 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/40681864
Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy. Lek A, Zhang Y, Woodman KG, Huang S, DeSimone AM, Cohen J, Ho V, Conner J, Mead L, Kodani A, Pakula A, Sanjana N, King OD, Jones PL, Wagner KR, Lek M, Kunkel LM Science translational medicine 32213627 Sci Transl Med 2020 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/32213627
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens. Liscovitch-Brauer N, Montalbano A, Deng J, Méndez-Mancilla A, Wessels HH, Moss NG, Kung CY, Sookdeo A, Guo X, Geller E, Jaini S, Smibert P, Sanjana NE Nature biotechnology 33927415 Nat Biotechnol 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/33927415
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome. Montalbano A, Canver MC, Sanjana NE Molecular cell 28985510 Mol Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28985510
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Kasela S, Daniloski Z, Bollepalli S, Jordan TX, tenOever BR, Sanjana NE, Lappalainen T Genome biology 34425859 Genome Biol 2021 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/34425859
Expanding the Scope of Bacterial CRISPR Activation with PAM-Flexible dCas9 Variants. Kiattisewee C, Karanjia AV, Legut M, Daniloski Z, Koplik SE, Nelson J, Kleinstiver BP, Sanjana NE, Carothers JM, Zalatan JG ACS synthetic biology 36378874 ACS Synth Biol 2022 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/36378874
Essential transcription factors for induced neuron differentiation. Lu C, Garipler G, Dai C, Roush T, Salome-Correa J, Martin A, Liscovitch-Brauer N, Mazzoni EO, Sanjana NE Nature communications 38102126 Nat Commun 2023 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/38102126
Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens. Guo X, Rahman JA, Wessels HH, Méndez-Mancilla A, Haro D, Chen X, Sanjana NE Cell genomics 35664829 Cell Genom 2021 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/35664829
Cancer genes disfavoring T cell immunity identified via integrated systems approach. Kishton RJ, Patel SJ, Decker AE, Vodnala SK, Cam M, Yamamoto TN, Patel Y, Sukumar M, Yu Z, Ji M, Henning AN, Gurusamy D, Palmer DC, Stefanescu RA, Girvin AT, Lo W, Pasetto A, Malekzadeh P, Deniger DC, Wood KC, Sanjana NE, Restifo NP Cell reports 35926468 Cell Rep 2022 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/35926468
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling. Yan RE, Corman A, Katgara L, Wang X, Xue X, Gajic ZZ, Sam R, Farid M, Friedman SM, Choo J, Raimondi I, Ganesan S, Katsevich E, Greenfield JP, Dahmane N, Sanjana NE Nature biotechnology 39572737 Nat Biotechnol 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/39572737
Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. Lu C, Shi X, Allen A, Baez-Nieto D, Nikish A, Sanjana NE, Pan JQ FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30698461 FASEB J 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30698461
A genome-wide net to catch and understand cancer. Sanjana NE Science translational medicine 30089637 Sci Transl Med 2018 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/30089637
Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A). Lu C, Sanjana NE Stem cell research 31707212 Stem Cell Res 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31707212
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types. Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE bioRxiv : the preprint server for biology 32587969 bioRxiv 2020 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/32587969
Prediction of on-target and off-target activity of CRISPR-Cas13d guide RNAs using deep learning. Wessels HH, Stirn A, Méndez-Mancilla A, Kim EJ, Hart SK, Knowles DA, Sanjana NE Nature biotechnology 37400521 Nat Biotechnol 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/37400521
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. Kasela S, Daniloski Z, Jordan TX, tenOever BR, Sanjana NE, Lappalainen T medRxiv : the preprint server for health sciences 33880488 medRxiv 2021 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/33880488
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes. Garipler G, Lu C, Morrissey A, Lopez-Zepeda LS, Pei Y, Vidal SE, Zen Petisco Fiore AP, Aydin B, Stadtfeld M, Ohler U, Mahony S, Sanjana NE, Mazzoni EO Cell reports 35294876 Cell Rep 2022 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/35294876
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H Proceedings of the National Academy of Sciences of the United States of America 38743625 Proc Natl Acad Sci U S A 2024 May 21 https://www.ncbi.nlm.nih.gov/pubmed/38743625
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox. Schertzer MD, Stirn A, Isaev K, Pereira L, Park SH, Das A, Réal A, Jeffery ED, Harbison C, Wessels HH, Sheynkman GM, Sanjana NE, Knowles DA Nature communications 40730819 Nat Commun 2025 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/40730819
GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease. Li L, Tian E, Chen X, Chao J, Klein J, Qu Q, Sun G, Sun G, Huang Y, Warden CD, Ye P, Feng L, Li X, Cui Q, Sultan A, Douvaras P, Fossati V, Sanjana NE, Riggs AD, Shi Y Cell stem cell 30075130 Cell Stem Cell 2018 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/30075130
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, Dhingra P, Wong EWP, Chi P, Apostolou E, Sanjana NE, Khurana E Cell systems 31078526 Cell Syst 2019 May 22 https://www.ncbi.nlm.nih.gov/pubmed/31078526
Recurrent somatic mutations as predictors of immunotherapy response. Gajic ZZ, Deshpande A, Legut M, Imieliński M, Sanjana NE Nature communications 35803911 Nat Commun 2022 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/35803911
Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells. Mimitou EP, Cheng A, Montalbano A, Hao S, Stoeckius M, Legut M, Roush T, Herrera A, Papalexi E, Ouyang Z, Satija R, Sanjana NE, Koralov SB, Smibert P Nature methods 31011186 Nat Methods 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31011186
Massively parallel Cas13 screens reveal principles for guide RNA design. Wessels HH, Méndez-Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana NE Nature biotechnology 32518401 Nat Biotechnol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32518401
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE Cell 33147445 Cell 2021 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/33147445
Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity. Sorek M, Oweis W, Nissim-Rafinia M, Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, Zhang F, Levin JZ, Meshorer E Genome biology 33663567 Genome Biol 2021 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/33663567
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells. Méndez-Mancilla A, Wessels HH, Legut M, Kadina A, Mabuchi M, Walker J, Robb GB, Holden K, Sanjana NE Cell chemical biology 34343484 Cell Chem Biol 2022 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/34343484
Tracking cell lineages to improve research reproducibility. Zaaijer S, Groen SC, Sanjana NE Nature biotechnology 34012093 Nat Biotechnol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34012093
RETRACTED: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells. Liang WW, Müller S, Hart SK, Wessels HH, Méndez-Mancilla A, Sookdeo A, Choi O, Caragine CM, Corman A, Lu L, Kolumba O, Williams B, Sanjana NE Cell 39532094 Cell 2024 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/39532094
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers. Caragine CM, Le VT, Mustafa M, Diaz BJ, Morris JA, Müller S, Mendez-Mancilla A, Geller E, Liscovitch-Brauer N, Sanjana NE Nature communications 39948336 Nat Commun 2025 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/39948336
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Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition. Wei W, Geer MJ, Guo X, Dolgalev I, Sanjana NE, Neel BG The Journal of experimental medicine 36820830 J Exp Med 2023 May 1 https://www.ncbi.nlm.nih.gov/pubmed/36820830
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Gut bacteria-derived serotonin promotes immune tolerance in early life. Sanidad KZ, Rager SL, Carrow HC, Ananthanarayanan A, Callaghan R, Hart LR, Li T, Ravisankar P, Brown JA, Amir M, Jin JC, Savage AR, Luo R, Rowdo FM, Martin ML, Silver RB, Guo CJ, Krumsiek J, Inohara N, Zeng MY Science immunology 38489352 Sci Immunol 2024 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/38489352
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Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Li Z, Low V, Luga V, Sun J, Earlie E, Parang B, Shobana Ganesh K, Cho S, Endress J, Schild T, Hu M, Lyden D, Jin W, Guo C, Dephoure N, Cantley LC, Laughney AM, Blenis J Nature communications 36266345 Nat Commun 2022 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/36266345
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. Arifuzzaman M, Won TH, Li TT, Yano H, Digumarthi S, Heras AF, Zhang W, Parkhurst CN, Kashyap S, Jin WB, Putzel GG, Tsou AM, Chu C, Wei Q, Grier A, JRI IBD Live Cell Bank Consortium, Worgall S, Guo CJ, Schroeder FC, Artis D Nature 36323778 Nature 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36323778
Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity. Jin WB, Xiao L, Jeong M, Han SJ, Zhang W, Yano H, Shi H, Arifuzzaman M, Lyu M, Wang D, Tang YA, Qiao S, JRI IBD Live Cell Bank Consortium, Yang X, Yang HS, Fu J, Sonnenberg GF, Collins N, Artis D, Guo CJ Cell 40239649 Cell 2025 May 1 https://www.ncbi.nlm.nih.gov/pubmed/40239649
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Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation. Arifuzzaman M, Collins N, Guo CJ, Artis D Immunity 38198849 Immunity 2024 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/38198849
Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation. Sargsian S, Mondragón-Palomino O, Lejeune A, Ercelen D, Jin WB, Varghese A, Lim YAL, Guo CJ, Loke P, Cadwell K Microbiome 38730492 Microbiome 2024 May 10 https://www.ncbi.nlm.nih.gov/pubmed/38730492
Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL Journal of the neurological sciences 33497950 J Neurol Sci 2021 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/33497950
Optimizing the accuracy of cortical volumetric analysis in traumatic brain injury. Diamond BR, Donald CLM, Frau-Pascual A, Snider SB, Fischl B, Dams-O'Connor K, Edlow BL MethodsX 32760659 MethodsX 2020 https://www.ncbi.nlm.nih.gov/pubmed/32760659
Unmasking Covert Language Processing in the Intensive Care Unit with Electroencephalography. Edlow BL, Naccache L Annals of neurology 33491250 Ann Neurol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33491250
The Quest for Covert Consciousness: Bringing Neuroethics to the Bedside. Young MJ, Edlow BL Neurology 33653901 Neurology 2021 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33653901
MRI in disorders of consciousness. Snider SB, Edlow BL Current opinion in neurology 33044234 Curr Opin Neurol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33044234
A state-space model for dynamic functional connectivity. Chakravarty S, Threlkeld ZD, Bodien YG, Edlow BL, Brown EN Conference record. Asilomar Conference on Signals, Systems & Computers 32801606 Conf Rec Asilomar Conf Signals Syst Comput 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/32801606
Long-Term Recovery from Disordered Consciousness Associated with COVID-19. Fischer D, Edlow BL Neurocritical care 34642843 Neurocrit Care 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34642843
Quantitative epileptiform burden and electroencephalography background features predict post-traumatic epilepsy. Chen Y, Li S, Ge W, Jing J, Chen HY, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher CB, Smith C, Maciel CB, Alkhachroum A, Lee JW, Dhakar MB, Gilmore EJ, Sivaraju A, Hirsch LJ, Omay SB, Blumenfeld H, Sheth KN, Struck AF, Edlow BL, Westover MB, Kim JA Journal of neurology, neurosurgery, and psychiatry 36241423 J Neurol Neurosurg Psychiatry 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36241423
Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations. Fischer D, Rapalino O, Fecchio M, Edlow BL Brain sciences 36552169 Brain Sci 2022 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/36552169
Correcting cardiorespiratory noise in resting-state functional MRI data acquired in critically ill patients. Chan ST, Sanders WR, Fischer D, Kirsch JE, Napadow V, Bodien YG, Edlow BL Brain communications 36382222 Brain Commun 2022 https://www.ncbi.nlm.nih.gov/pubmed/36382222
Early Seizures Are Predictive of Worse Health-Related Quality of Life at Follow-Up After Intracerebral Hemorrhage. Naidech AM, Weaver B, Maas M, Bleck TP, VanHaerents S, Schuele SU Critical care medicine 33729725 Crit Care Med 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/33729725
Joint super-resolution and synthesis of 1 mm isotropic MP-RAGE volumes from clinical MRI exams with scans of different orientation, resolution and contrast. Iglesias JE, Billot B, Balbastre Y, Tabari A, Conklin J, Gilberto González R, Alexander DC, Golland P, Edlow BL, Fischl B, Alzheimer’s Disease Neuroimaging Initiative NeuroImage 34048902 Neuroimage 2021 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/34048902
SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry. Iglesias JE, Billot B, Balbastre Y, Magdamo C, Arnold SE, Das S, Edlow BL, Alexander DC, Golland P, Fischl B Science advances 36724222 Sci Adv 2023 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/36724222
Automated MRI Segmentation of Brainstem Nuclei Critical to Consciousness. Olchanyi MD, Augustinack J, Haynes RL, Lewis LD, Cicero N, Li J, Destrieux C, Folkerth RD, Kinney HC, Fischl B, Brown EN, Iglesias JE, Edlow BL Human brain mapping 41074651 Hum Brain Mapp 2025 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/41074651
Unsupervised semi-automated MRI segmentation detects cortical lesion expansion in chronic traumatic brain injury. Freeman HJ, Atalay AS, Li J, Sobczak E, Gilmore N, Snider SB, Healy BC, Carrington H, Selmanovic E, Pruyser A, Bura L, Sheppard DP, Hunt D, Seifert AC, Bodien YG, Hoffman JM, Mac Donald CL, Dams-O'Connor K, Edlow BL Frontiers in neurology 41170325 Front Neurol 2025 https://www.ncbi.nlm.nih.gov/pubmed/41170325
Probabilistic mapping and automated segmentation of human brainstem white matter bundles. Olchanyi MD, Schreier DR, Li J, Maffei C, Sorby-Adams A, Kinney HC, Healy BC, Freeman HJ, Shless J, Destrieux C, Tregidgo H, Iglesias JE, Brown EN, Edlow BL Proceedings of the National Academy of Sciences of the United States of America 41650217 Proc Natl Acad Sci U S A 2026 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/41650217
Emotional Processing After Severe Traumatic Brain Injury: Insights from Functional MRI and Pupillometry. Kazazian K, Zhang SO, de Jeu J, Lawrence PK, Sanders WR, Meydan A, Bremner F, Mallas EJ, Bodien YG, Dams-O'Connor K, Edlow BL, Li LM medRxiv : the preprint server for health sciences 40832426 medRxiv 2025 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/40832426
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury. Kumar RG, Selmanovic E, Gilmore N, Spielman L, Li LM, Hoffman JM, Bodien YG, Snider SB, Freeman HJ, de Souza NL, Mac Donald CL, Edlow BL, Dams-O'Connor K Brain communications 40574978 Brain Commun 2025 https://www.ncbi.nlm.nih.gov/pubmed/40574978
Increased task-relevant fMRI responsiveness in comatose cardiac arrest patients is associated with improved neurologic outcomes. Dhakal K, Rosenthal ES, Kulpanowski AM, Dodelson JA, Wang Z, Cudemus-Deseda G, Villien M, Edlow BL, Presciutti AM, Januzzi JL, Ning M, Taylor Kimberly W, Amorim E, Brandon Westover M, Copen WA, Schaefer PW, Giacino JT, Greer DM, Wu O Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37728641 J Cereb Blood Flow Metab 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37728641
Common data elements for disorders of consciousness. Edlow BL, Claassen J, Suarez JI Neurocritical care 38291278 Neurocrit Care 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38291278
Model-based navigation of transcranial focused ultrasound neuromodulation in humans: Application to targeting the amygdala and thalamus. Daneshzand M, Guerin B, Kotlarz P, Chou T, Dougherty DD, Edlow BL, Nummenmaa A Brain stimulation 39094682 Brain Stimul 2024 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/39094682
Toward Uniform Insurer Coverage for Functional MRI Following Severe Brain Injury. Young MJ, Bodien YG, Freeman HJ, Fecchio M, Edlow BL The Journal of head trauma rehabilitation 36854104 J Head Trauma Rehabil 2023 Jul-Aug 01 https://www.ncbi.nlm.nih.gov/pubmed/36854104
A human brain network linked to restoration of consciousness after deep brain stimulation. Warren AEL, Raguž M, Friedrich H, Schaper FLWVJ, Tasserie J, Snider SB, Li J, Chua MMJ, Butenko K, Friedrich MU, Jha R, Iglesias JE, Carney PW, Fischer D, Fox MD, Boes AD, Edlow BL, Horn A, Chudy D, Rolston JD medRxiv : the preprint server for health sciences 39484242 medRxiv 2024 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/39484242
Acute biomarkers of consciousness are associated with recovery after severe traumatic brain injury. Bodien YG, Fecchio M, Gilmore N, Freeman HJ, Sanders WR, Meydan A, Lawrence PK, Atalay AS, Kirsch J, Healy BC, Edlow BL medRxiv : the preprint server for health sciences 40093212 medRxiv 2025 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/40093212
Histology-guided MRI segmentation of brainstem nuclei critical to consciousness. Olchanyi MD, Augustinack J, Haynes RL, Lewis LD, Cicero N, Li J, Destrieux C, Folkerth RD, Kinney HC, Fischl B, Brown EN, Iglesias JE, Edlow BL medRxiv : the preprint server for health sciences 39399006 medRxiv 2024 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/39399006
Covert consciousness. Young MJ, Edlow BL, Bodien YG NeuroRehabilitation 38217619 NeuroRehabilitation 2024 https://www.ncbi.nlm.nih.gov/pubmed/38217619
Disclosing Results of Tests for Covert Consciousness: A Framework for Ethical Translation. Young MJ, Kazazian K, Fischer D, Lissak IA, Bodien YG, Edlow BL Neurocritical care 38243150 Neurocrit Care 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38243150
Feasibility and Validity of the Coma Recovery Scale-Revised for Accelerated Standardized Testing: A Practical Assessment Tool for Detecting Consciousness in the Intensive Care Unit. Bodien YG, Vora I, Barra A, Chiang K, Chatelle C, Goostrey K, Martens G, Malone C, Mello J, Parlman K, Ranford J, Sterling A, Waters AB, Hirschberg R, Katz DI, Mazwi N, Ni P, Velmahos G, Waak K, Edlow BL, Giacino JT Annals of neurology 37488068 Ann Neurol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37488068
Multicenter prospective study on predictors of short-term outcome in disorders of consciousness. Estraneo A, Fiorenza S, Magliacano A, Formisano R, Mattia D, Grippo A, Romoli AM, Angelakis E, Cassol H, Thibaut A, Gosseries O, Lamberti G, Noé E, Bagnato S, Edlow BL, Chatelle C, Lejeune N, Veeramuthu V, Bartolo M, Toppi J, Zasler N, Schnakers C, Trojano L, IBIA DoC-SIG Neurology 32661102 Neurology 2020 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/32661102
Common Data Elements for COVID-19 Neuroimaging: A GCS-NeuroCOVID Proposal. Edlow BL, Boly M, Chou SH, Fischer D, Kondziella D, Li LM, Mac Donald CL, McNett M, Newcombe VFJ, Stevens RD, Menon DK, GCS-NeuroCOVID Neurocritical care 33575956 Neurocrit Care 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33575956
Dopaminergic modulation of human consciousness via default mode network connectivity. Edlow BL Proceedings of the National Academy of Sciences of the United States of America 34330840 Proc Natl Acad Sci U S A 2021 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/34330840
Mapping a memory disorder using functional network analysis. Edlow BL Acta neurologica Scandinavica 34231225 Acta Neurol Scand 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34231225
EEG Correlates of Language Function in Traumatic Disorders of Consciousness. Chatelle C, Rosenthal ES, Bodien YG, Spencer-Salmon CA, Giacino JT, Edlow BL Neurocritical care 31900883 Neurocrit Care 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/31900883
Risk factors for 2-year mortality in patients with prolonged disorders of consciousness: An international multicentre study. Estraneo A, Magliacano A, Fiorenza S, Formisano R, Grippo A, Angelakis E, Cassol H, Thibaut A, Gosseries O, Lamberti G, Noé E, Bagnato S, Edlow BL, Chatelle C, Lejeune N, Veeramuthu V, Bartolo M, Mattia D, Toppi J, Zasler N, Schnakers C, Trojano L European journal of neurology 34657359 Eur J Neurol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34657359
Early Rehabilitation for Patients with Disorders of Consciousness after Severe COVID-19. Edlow BL Neurocritical care 34617252 Neurocrit Care 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/34617252
One-Year Outcomes in Disorders of Consciousness Associated with COVID-19. Fischer D, Edlow BL Neurocritical care 36324001 Neurocrit Care 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36324001
Prolonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia. Waldrop G, Safavynia SA, Barra ME, Agarwal S, Berlin DA, Boehme AK, Brodie D, Choi JM, Doyle K, Fins JJ, Ganglberger W, Hoffman K, Mittel AM, Roh D, Mukerji SS, Der Nigoghossian C, Park S, Schenck EJ, Salazar-Schicchi J, Shen Q, Sholle E, Velazquez AG, Walline MC, Westover MB, Brown EN, Victor J, Edlow BL, Schiff ND, Claassen J Annals of neurology 35254675 Ann Neurol 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/35254675
Severe cerebral edema in substance-related cardiac arrest patients. Kulpanowski AM, Copen WA, Hancock BL, Rosenthal ES, Schoenfeld DA, Dodelson JA, Edlow BL, Kimberly WT, Amorim E, Westover MB, Ning MM, Schaefer PW, Malhotra R, Giacino JT, Greer DM, Wu O Resuscitation 35149137 Resuscitation 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35149137
Neuroprognostication: a conceptual framework. Fischer D, Edlow BL, Giacino JT, Greer DM Nature reviews. Neurology 35352033 Nat Rev Neurol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35352033
Predicting Long-Term Recovery of Consciousness in Prolonged Disorders of Consciousness Based on Coma Recovery Scale-Revised Subscores: Validation of a Machine Learning-Based Prognostic Index. Magliacano A, Liuzzi P, Formisano R, Grippo A, Angelakis E, Thibaut A, Gosseries O, Lamberti G, Noé E, Bagnato S, Edlow BL, Lejeune N, Veeramuthu V, Trojano L, Zasler N, Schnakers C, Bartolo M, Mannini A, Estraneo A, IBIA DoC-SIG Brain sciences 36672033 Brain Sci 2022 Dec 27 https://www.ncbi.nlm.nih.gov/pubmed/36672033
What is a minimal clinically important difference for clinical trials in patients with disorders of consciousness? a novel probabilistic approach. Monti MM, Spivak NM, Edlow BL, Bodien YG PloS one 37616196 PLoS One 2023 https://www.ncbi.nlm.nih.gov/pubmed/37616196
Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap. Schiff ND, Diringer M, Diserens K, Edlow BL, Gosseries O, Hill NJ, Hochberg LR, Ismail FY, Meyer IA, Mikell CB, Mofakham S, Molteni E, Polizzotto L, Shah SA, Stevens RD, Thengone D, and the Curing Coma Campaign and its Contributing Members Neurocritical care 38286946 Neurocrit Care 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38286946
Coma Prognostication After Acute Brain Injury: A Review. Fischer D, Edlow BL JAMA neurology 38436946 JAMA Neurol 2024 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/38436946
Are disorders of consciousness 'dis'connection or 'dys'connection syndromes? Edlow BL, Massimini M Brain communications 38410155 Brain Commun 2023 https://www.ncbi.nlm.nih.gov/pubmed/38410155
Visualizing effective connectivity in the human brain. Atalay AS, Fecchio M, Edlow BL Brain stimulation 40550389 Brain Stimul 2025 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/40550389
Behavioral Fluctuation in Disorders of Consciousness: A Retrospective Analysis. Barra A, Bodien YG, Tan CO, Martens G, Malone C, Giacino JT Archives of physical medicine and rehabilitation 40139629 Arch Phys Med Rehabil 2025 Oct https://www.ncbi.nlm.nih.gov/pubmed/40139629
Visualizing Effective Connectivity in the Human Brain. Atalay AS, Fecchio M, Edlow BL bioRxiv : the preprint server for biology 40161749 bioRxiv 2025 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/40161749
Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness. Edlow BL, Olchanyi M, Freeman HJ, Li J, Maffei C, Snider SB, Zöllei L, Iglesias JE, Augustinack J, Bodien YG, Haynes RL, Greve DN, Diamond BR, Stevens A, Giacino JT, Destrieux C, van der Kouwe A, Brown EN, Folkerth RD, Fischl B, Kinney HC Science translational medicine 38691619 Sci Transl Med 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38691619
Automated Measurement of Cerebral Hemorrhagic Contusions and Outcomes After Traumatic Brain Injury in the TRACK-TBI Study. Snider SB, Temkin NR, Sun X, Stubbs JL, Rademaker QJ, Markowitz AJ, Rosenthal ES, Diaz-Arrastia R, Fox MD, Manley GT, Jain S, Edlow BL, TRACK-TBI Investigators JAMA network open 39212991 JAMA Netw Open 2024 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/39212991
Cross-regional coordination of activity in the human brain during autobiographical self-referential processing. Stieger JR, Pinheiro-Chagas P, Fang Y, Li J, Lusk Z, Perry CM, Girn M, Contreras D, Chen Q, Huguenard JR, Spreng RN, Edlow BL, Wagner AD, Buch V, Parvizi J Proceedings of the National Academy of Sciences of the United States of America 39078679 Proc Natl Acad Sci U S A 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39078679
Subcortical Hubs of Brain Networks Sustaining Human Consciousness. Cambareri MK, Horn A, Lewis LD, Li J, Edlow BL Human brain mapping 41074653 Hum Brain Mapp 2025 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/41074653
Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury. Snider SB, Shi H, Bodien YG, Howard C, Sun X, Golby AJ, Zimmerman KA, Bertolini G, Magnoni S, Dunet V, Oddo M, Graham NSN, Mallas EJ, Moro F, Mukherjee P, Temkin NR, Jain S, Sharp DJ, Edlow BL, Fox MD Proceedings of the National Academy of Sciences of the United States of America 41428880 Proc Natl Acad Sci U S A 2025 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/41428880
7 Tesla MRI of the ex vivo human brain at 100 micron resolution. Edlow BL, Mareyam A, Horn A, Polimeni JR, Witzel T, Tisdall MD, Augustinack JC, Stockmann JP, Diamond BR, Stevens A, Tirrell LS, Folkerth RD, Wald LL, Fischl B, van der Kouwe A Scientific data 31666530 Sci Data 2019 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/31666530
Intact Brain Network Function in an Unresponsive Patient with COVID-19. Fischer D, Threlkeld ZD, Bodien YG, Kirsch JE, Huang SY, Schaefer PW, Rapalino O, Hochberg LR, Rosen BR, Edlow BL Annals of neurology 32613682 Ann Neurol 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32613682
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG Neurocritical care 32794142 Neurocrit Care 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/32794142
Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study. Snider SB, Temkin NR, Barber J, Edlow BL, Giacino JT, Hammond FM, Izzy S, Kowalski RG, Markowitz AJ, Rovito CA, Shih SL, Zafonte RD, Manley GT, Bodien YG, TRACK-TBI investigators Annals of neurology 37470289 Ann Neurol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37470289
Sustaining wakefulness: Brainstem connectivity in human consciousness. Edlow BL, Olchanyi M, Freeman HJ, Li J, Maffei C, Snider SB, Zöllei L, Iglesias JE, Augustinack J, Bodien YG, Haynes RL, Greve DN, Diamond BR, Stevens A, Giacino JT, Destrieux C, van der Kouwe A, Brown EN, Folkerth RD, Fischl B, Kinney HC bioRxiv : the preprint server for biology 37502983 bioRxiv 2023 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/37502983
Location of Subcortical Microbleeds and Recovery of Consciousness After Severe Traumatic Brain Injury. Bianciardi M, Izzy S, Rosen BR, Wald LL, Edlow BL Neurology 34050005 Neurology 2021 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/34050005
Emerging Consciousness at a Clinical Crossroads. Young MJ, Edlow BL AJOB neuroscience 33960885 AJOB Neurosci 2021 Apr-Sep https://www.ncbi.nlm.nih.gov/pubmed/33960885
Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies. Edlow BL, Claassen J, Schiff ND, Greer DM Nature reviews. Neurology 33318675 Nat Rev Neurol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33318675
Transcranial Pulsed-Current Stimulation versus Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Pilot, Sham-Controlled Cross-Over Double-Blind Study. Barra A, Rosenfelder M, Mortaheb S, Carrière M, Martens G, Bodien YG, Morales-Quezada L, Bender A, Laureys S, Thibaut A, Fregni F Brain sciences 35447961 Brain Sci 2022 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/35447961
Ascending arousal network connectivity during recovery from traumatic coma. Snider SB, Bodien YG, Frau-Pascual A, Bianciardi M, Foulkes AS, Edlow BL NeuroImage. Clinical 33395992 Neuroimage Clin 2020 https://www.ncbi.nlm.nih.gov/pubmed/33395992
Update on neuroimaging in disorders of consciousness. Sanz LRD, Thibaut A, Edlow BL, Laureys S, Gosseries O Current opinion in neurology 34054109 Curr Opin Neurol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/34054109
Defining the boundary between life and death: New insights from neuropathology. Edlow BL, Kinney HC Journal of neuropathology and experimental neurology 36519398 J Neuropathol Exp Neurol 2022 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/36519398
Pharmacologic Therapies to Promote Recovery of Consciousness. Barra ME, Edlow BL, Brophy GM Seminars in neurology 36100228 Semin Neurol 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/36100228
Conventional and Investigational Approaches Leveraging Clinical EEG for Prognosis in Acute Disorders of Consciousness. Curley WH, Comanducci A, Fecchio M Seminars in neurology 36100227 Semin Neurol 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/36100227
Recovery Potential in Patients Who Died After Withdrawal of Life-Sustaining Treatment: A TRACK-TBI Propensity Score Analysis. Sanders WR, Barber JK, Temkin NR, Foreman B, Giacino JT, Williamson T, Edlow BL, Manley GT, Bodien YG Journal of neurotrauma 38739032 J Neurotrauma 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38739032
Multimodal Biomarkers of Consciousness in Acute Severe Traumatic Brain Injury. Bodien YG, Fecchio M, Gilmore N, Freeman HJ, Sanders WR, Meydan A, Lawrence PK, Atalay AS, Kirsch J, Healy BC, Edlow BL Journal of neurotrauma 41182259 J Neurotrauma 2026 Mar https://www.ncbi.nlm.nih.gov/pubmed/41182259
Structural injuries are associated with better emotional wellbeing after traumatic brain injury. Snider SB, Shi H, Maffei C, Gilmore N, Freeman HJ, Atalay AS, Li J, Yeager JA, Kumar RG, Yew B, Conley EM, Velazquez AL, Kirschenbaum J, Selmanovic E, Carrington H, Bodien YG, Hoffman JM, Donald CM, Edlow BL, Dams-O'Connor K medRxiv : the preprint server for health sciences 40778143 medRxiv 2025 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/40778143
JOSA: Joint surface-based registration and atlas construction of brain geometry and function. Li J, Tuckute G, Fedorenko E, Edlow BL, Dalca AV, Fischl B Medical image analysis 39173411 Med Image Anal 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39173411
Three-dimensional fiber orientation mapping of the human brain at micrometer resolution. Liu CJ, Ammon W, Jones RJ, Nolan JC, Gong D, Maffei C, Edlow BL, Augustinack JC, Magnain C, Yendiki A, Villiger M, Fischl B, Wang H Research square 39149445 Res Sq 2024 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/39149445
A human brain network linked to restoration of consciousness after deep brain stimulation. Warren AEL, Raguž M, Friedrich H, Schaper FLWVJ, Tasserie J, Snider SB, Li J, Chua MMJ, Butenko K, Friedrich MU, Jha R, Iglesias JE, Carney PW, Fischer D, Fox MD, Boes AD, Edlow BL, Horn A, Chudy D, Rolston JD Nature communications 40691170 Nat Commun 2025 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/40691170
Electrophysiological correlates of thalamocortical function in acute severe traumatic brain injury. Curley WH, Bodien YG, Zhou DW, Conte MM, Foulkes AS, Giacino JT, Victor JD, Schiff ND, Edlow BL Cortex; a journal devoted to the study of the nervous system and behavior 35569326 Cortex 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35569326
Stability of extemporaneously prepared preservative-free methylphenidate 5 mg/mL intravenous solution. Barra ME, Edlow BL, Lund JT, DeSanctis KS, Vetrano J, Reilly-Tremblay C, Zhang ER, Bodien YG, Brown EN, Solt K American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 34788364 Am J Health Syst Pharm 2022 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/34788364
Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study. Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond BR, Wang R, Markowitz AJ, Fischl B, Perl DP, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL, TRACK-TBI Investigators Journal of neurotrauma 33412995 J Neurotrauma 2021 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/33412995
Reemergence of the language network during recovery from severe traumatic brain injury: A pilot functional MRI study. Coffey BJ, Threlkeld ZD, Foulkes AS, Bodien YG, Edlow BL Brain injury 34546806 Brain Inj 2021 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/34546806
Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions. Edlow BL, Sanz LRD, Polizzotto L, Pouratian N, Rolston JD, Snider SB, Thibaut A, Stevens RD, Gosseries O, Curing Coma Campaign and its contributing members Neurocritical care 34236624 Neurocrit Care 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34236624
The neuroethics of disorders of consciousness: a brief history of evolving ideas. Young MJ, Bodien YG, Giacino JT, Fins JJ, Truog RD, Hochberg LR, Edlow BL Brain : a journal of neurology 34347037 Brain 2021 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/34347037
Prognostication in Acute Neurological Emergencies. Sloane KL, Miller JJ, Piquet A, Edlow BL, Rosenthal ES, Singhal AB Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 35007934 J Stroke Cerebrovasc Dis 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35007934
Mapping the subcortical connectivity of the human default mode network. Li J, Curley WH, Guerin B, Dougherty DD, Dalca AV, Fischl B, Horn A, Edlow BL NeuroImage 34838949 Neuroimage 2021 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/34838949
Covert cortical processing: a diagnosis in search of a definition. Young MJ, Fecchio M, Bodien YG, Edlow BL Neuroscience of consciousness 38327828 Neurosci Conscious 2024 https://www.ncbi.nlm.nih.gov/pubmed/38327828
Automated detection of axonal damage along white matter tracts in acute severe traumatic brain injury. Maffei C, Gilmore N, Snider SB, Foulkes AS, Bodien YG, Yendiki A, Edlow BL NeuroImage. Clinical 36529035 Neuroimage Clin 2023 https://www.ncbi.nlm.nih.gov/pubmed/36529035
Alpha coherence is a network signature of cognitive recovery from disorders of consciousness. Zhou DW, Conte MM, Curley WH, Spencer-Salmon CA, Chatelle C, Rosenthal ES, Bodien YG, Victor JD, Schiff ND, Brown EN, Edlow BL medRxiv : the preprint server for health sciences 39417105 medRxiv 2024 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/39417105
Cognitive Motor Dissociation in Disorders of Consciousness. Bodien YG, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh JE, Kamau E, Lawrence PK, Lupson VC, Meydan A, Rohaut B, Sanders WR, Sitt JD, Soddu A, Valente M, Velazquez A, Voss HU, Vrosgou A, Claassen J, Edlow BL, Fins JJ, Gosseries O, Laureys S, Menon D, Naccache L, Owen AM, Pickard J, Stamatakis EA, Thibaut A, Victor JD, Giacino JT, Bagiella E, Schiff ND The New England journal of medicine 39141852 N Engl J Med 2024 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/39141852
Cognitive Performance is Associated With 1-Year Participation and Life Satisfaction Outcomes: A Traumatic Brain Injury Model Systems Study. Gilmore N, Bergquist TF, Bogner J, Corrigan JD, Dams-O'Connor K, Dreer LE, Healy BC, Juengst SB, Kumar RG, O'Neil-Pirozzi TM, Wagner AK, Giacino JT, Edlow BL, Bodien YG The Journal of head trauma rehabilitation 39330921 J Head Trauma Rehabil 2025 May-Jun 01 https://www.ncbi.nlm.nih.gov/pubmed/39330921
Three-dimensional fiber orientation mapping of ex vivo human brain at micrometer resolution. Liu CJ, Ammon W, Jones RJ, Nolan JC, Gong D, Maffei C, Blanke N, Edlow BL, Augustinack JC, Magnain C, Yendiki A, Villiger M, Fischl B, Wang H Npj imaging 40213097 Npj Imaging 2025 https://www.ncbi.nlm.nih.gov/pubmed/40213097
Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury. Kumar RG, Selmanovic E, Gilmore N, Spielman L, Li LM, Hoffman JM, Bodien YG, Snider SB, Freeman HJ, de Souza NL, Donald CLM, Edlow BL, Dams-O'Connor K medRxiv : the preprint server for health sciences 39974133 medRxiv 2025 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/39974133
Cortical lesions and focal white matter injury are associated with attentional performance in chronic traumatic brain injury. Snider SB, Gilmore N, Freeman HJ, Maffei C, Atalay A, Kumar RG, Li LM, Shi H, Bodien YG, Mac Donald CL, Dams-O'Connor K, Edlow BL Brain communications 39926612 Brain Commun 2025 https://www.ncbi.nlm.nih.gov/pubmed/39926612
Measuring Consciousness in the Intensive Care Unit. Edlow BL, Fecchio M, Bodien YG, Comanducci A, Rosanova M, Casarotto S, Young MJ, Li J, Dougherty DD, Koch C, Tononi G, Massimini M, Boly M Neurocritical care 37029315 Neurocrit Care 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37029315
Joint cortical registration of geometry and function using semi-supervised learning. Li J, Tuckute G, Fedorenko E, Edlow BL, Fischl B, Dalca AV ArXiv 37744470 ArXiv 2023 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/37744470
Characterizing coma in large vessel occlusion stroke. Young MJ, Awad A, Andreev A, Bonkhoff AK, Schirmer MD, Dmytriw AA, Vranic JE, Rabinov JD, Doron O, Stapleton CJ, Das AS, Edlow BL, Singhal AB, Rost NS, Patel AB, Regenhardt RW Journal of neurology 38366071 J Neurol 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38366071
Cortical Lesion Expansion in Chronic Traumatic Brain Injury. Freeman HJ, Atalay AS, Li J, Sobczak E, Gilmore N, Snider SB, Healy BC, Carrington H, Selmanovic E, Pruyser A, Bura L, Sheppard D, Hunt D, Seifert AC, Bodien YG, Hoffman JM, Mac Donald CL, Dams-O'Connor K, Edlow BL medRxiv : the preprint server for health sciences 38978662 medRxiv 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/38978662
Functional fractionation of large-scale brain networks in the human subcortex. Li J, Atalay AS, Olchanyi M, Cambareri MK, Ghosh SS, Horn A, Lewis L, Brown EN, Fischl B, Kinney HC, Edlow BL bioRxiv : the preprint server for biology 41509362 bioRxiv 2025 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/41509362
High Resolution Postmortem MRI Discovers Developing Structural Connectivity in the Human Ascending Arousal Network. Licandro R, Olchanyi M, Ferraz da Silva LF, van der Kouwe A, Jaimes C, Ngo NX, Kelley W, Folkerth R, Haynes RL, Edlow BL, Kinney HC, Zöllei L Human brain mapping 41319039 Hum Brain Mapp 2025 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/41319039
Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability. Lamson NG, Berger A, Fein KC, Whitehead KA Nature biomedical engineering 31686002 Nat Biomed Eng 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31686002
The Effect of Infant Gastric Digestion on Human Maternal Milk Cells. Doerfler R, Melamed JR, Whitehead KA Molecular nutrition & food research 35984112 Mol Nutr Food Res 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/35984112
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer. Melamed JR, Yerneni SS, Arral ML, LoPresti ST, Chaudhary N, Sehrawat A, Muramatsu H, Alameh MG, Pardi N, Weissman D, Gittes GK, Whitehead KA Science advances 36706177 Sci Adv 2023 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/36706177
Branched-Tail Lipid Nanoparticles for Intravenous mRNA Delivery to Lung Immune, Endothelial, and Alveolar Cells in Mice. Petersen DMS, Weiss RM, Hajj KA, Yerneni SS, Chaudhary N, Newby AN, Arral ML, Whitehead KA Advanced healthcare materials 38888972 Adv Healthc Mater 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38888972
Non-Viral RNA Delivery During Pregnancy: Opportunities and Challenges. Chaudhary N, Newby AN, Whitehead KA Small (Weinheim an der Bergstrasse, Germany) 38145340 Small 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38145340
Oral delivery of peptide therapeutics in infants: Challenges and opportunities. Gleeson JP, Fein KC, Whitehead KA Advanced drug delivery reviews 33774115 Adv Drug Deliv Rev 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33774115
mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Chaudhary N, Weissman D, Whitehead KA Nature reviews. Drug discovery 34433919 Nat Rev Drug Discov 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34433919
Profiling of mature-stage human breast milk cells identifies six unique lactocyte subpopulations. Gleeson JP, Chaudhary N, Fein KC, Doerfler R, Hredzak-Showalter P, Whitehead KA Science advances 35767604 Sci Adv 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35767604
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. Melamed JR, Hajj KA, Chaudhary N, Strelkova D, Arral ML, Pardi N, Alameh MG, Miller JB, Farbiak L, Siegwart DJ, Weissman D, Whitehead KA Journal of controlled release : official journal of the Controlled Release Society 34801660 J Control Release 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34801660
Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes. Chaudhary N, Newby AN, Arral ML, Yerneni SS, LoPresti ST, Doerfler R, Petersen DMS, Montoya C, Kim JS, Fox B, Coon T, Malaney A, Sadovsky Y, Whitehead KA Proceedings of the National Academy of Sciences of the United States of America 38437545 Proc Natl Acad Sci U S A 2024 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/38437545
The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery. Lamson NG, Fein KC, Gleeson JP, Newby AN, Xian S, Cochran K, Chaudhary N, Melamed JR, Ball RL, Suri K, Ahuja V, Zhang A, Berger A, Kolodieznyi D, Schmidt BF, Silva GL, Whitehead KA Proceedings of the National Academy of Sciences of the United States of America 35943988 Proc Natl Acad Sci U S A 2022 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/35943988
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d. Chaudhary N, Kasiewicz LN, Newby AN, Arral ML, Yerneni SS, Melamed JR, LoPresti ST, Fein KC, Strelkova Petersen DM, Kumar S, Purwar R, Whitehead KA Nature biomedical engineering 39363106 Nat Biomed Eng 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39363106
The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology. Gleeson JP, Fein KC, Chaudhary N, Doerfler R, Newby AN, Whitehead KA International journal of pharmaceutics 33249250 Int J Pharm 2021 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/33249250
The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs. LoPresti ST, Arral ML, Chaudhary N, Whitehead KA Journal of controlled release : official journal of the Controlled Release Society 35346768 J Control Release 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35346768
Characterization and comparison of human and mouse milk cells. Doerfler R, Yerneni S, Newby A, Chaudhary N, Shu A, Fein K, Hofstatter Azambuja J, Whitehead KA PloS one 38295101 PLoS One 2024 https://www.ncbi.nlm.nih.gov/pubmed/38295101
Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory control. Mokhtari T, Taheri MN, Akhlaghi S, Aryannejad A, Xiang Y, Mahajan V, Keshavarz K, Kiani A, LoPresti S, LeGraw R, Whitehead KA, Kiani S bioRxiv : the preprint server for biology 40060445 bioRxiv 2025 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/40060445
Maternal milk cell components are uptaken by infant liver macrophages via extracellular vesicle mediated transport. Doerfler R, Yerneni S, LoPresti S, Chaudhary N, Newby A, Melamed JR, Malaney A, Whitehead KA FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39835705 FASEB J 2025 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/39835705
The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism. Strelkova Petersen DM, Chaudhary N, Arral ML, Weiss RM, Whitehead KA European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 37838143 Eur J Pharm Biopharm 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37838143
Placental drug transport and fetal exposure during pregnancy is determined by drug molecular size, chemistry, and conformation. Fein KC, Arral ML, Kim JS, Newby AN, Whitehead KA Journal of controlled release : official journal of the Controlled Release Society 37473809 J Control Release 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37473809
Pushing the Envelope: Developments in Neural Entrainment to Speech and the Biological Underpinnings of Prosody Perception. Myers BR, Lense MD, Gordon RL Brain sciences 30909454 Brain Sci 2019 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/30909454
Neurophysiological Correlates of Dynamic Beat Tracking in Individuals With Williams Syndrome. Kasdan A, Gordon RL, Lense MD Biological psychiatry. Cognitive neuroscience and neuroimaging 33419711 Biol Psychiatry Cogn Neurosci Neuroimaging 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/33419711
Genetic and Environmental Influences on Semantic Verbal Fluency Across Midlife and Later Life. Gustavson DE, Panizzon MS, Kremen WS, Reynolds CA, Pahlen S, Nygaard M, Wod M, Catts VS, Lee T, Gatz M, Franz CE, IGEMS Consortium Behavior genetics 33547998 Behav Genet 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33547998
Medical phenome of musicians: an investigation of health records collected on 9803 musically active individuals. Niarchou M, Lin GT, Lense MD, Gordon RL, Davis LK Annals of the New York Academy of Sciences 34414577 Ann N Y Acad Sci 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34414577
Rhythm and timing as vulnerabilities in neurodevelopmental disorders. Lense MD, Ladányi E, Rabinowitch TC, Trainor L, Gordon R Philosophical transactions of the Royal Society of London. Series B, Biological sciences 34420385 Philos Trans R Soc Lond B Biol Sci 2021 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/34420385
Linking the genomic signatures of human beat synchronization and learned song in birds. Gordon RL, Ravignani A, Hyland Bruno J, Robinson CM, Scartozzi A, Embalabala R, Niarchou M, 23andMe Research Team, Cox NJ, Creanza N Philosophical transactions of the Royal Society of London. Series B, Biological sciences 34420388 Philos Trans R Soc Lond B Biol Sci 2021 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/34420388
A neurodevelopmental disorders perspective into music, social attention, and social bonding. Kasdan A, Gordon RL, Lense MD The Behavioral and brain sciences 34588066 Behav Brain Sci 2021 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/34588066
Heritability of Childhood Music Engagement and Associations with Language and Executive Function: Insights from the Adolescent Brain Cognitive Development (ABCD) Study. Gustavson DE, Nayak S, Coleman PL, Iversen JR, Lense MD, Gordon RL, Maes HH Behavior genetics 36757558 Behav Genet 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36757558
Identifying a brain network for musical rhythm: A functional neuroimaging meta-analysis and systematic review. Kasdan AV, Burgess AN, Pizzagalli F, Scartozzi A, Chern A, Kotz SA, Wilson SM, Gordon RL Neuroscience and biobehavioral reviews 35259422 Neurosci Biobehav Rev 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35259422
Genome-wide association study of musical beat synchronization demonstrates high polygenicity. Niarchou M, Gustavson DE, Sathirapongsasuti JF, Anglada-Tort M, Eising E, Bell E, McArthur E, Straub P, 23andMe Research Team, McAuley JD, Capra JA, Ullén F, Creanza N, Mosing MA, Hinds DA, Davis LK, Jacoby N, Gordon RL Nature human behaviour 35710621 Nat Hum Behav 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35710621
The Neural Correlates of Spontaneous Beat Processing and Its Relationship with Music-Related Characteristics of the Individual. Scartozzi AC, Wang Y, Bush CT, Kasdan AV, Fram NR, Woynaroski T, Lense MD, Gordon RL, Ladányi E eNeuro 39401929 eNeuro 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39401929
The shared genetic architecture and evolution of human language and musical rhythm. Alagöz G, Eising E, Mekki Y, Bignardi G, Fontanillas P, 23andMe Research Team, Nivard MG, Luciano M, Cox NJ, Fisher SE, Gordon RL bioRxiv : the preprint server for biology 37961248 bioRxiv 2023 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/37961248
Is atypical rhythm a risk factor for developmental speech and language disorders? Ladányi E, Persici V, Fiveash A, Tillmann B, Gordon RL Wiley interdisciplinary reviews. Cognitive science 32244259 Wiley Interdiscip Rev Cogn Sci 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32244259
Interprofessional education of the next generation of musician-scientists through music cognition research training: An innovative platform for health professions and biomedical research. Gordon RL, Lense MD Music and medicine 33603955 Music Med 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/33603955
Elevated Polygenic Burden for Autism Spectrum Disorder Is Associated With the Broad Autism Phenotype in Mothers of Individuals With Autism Spectrum Disorder. Nayar K, Sealock JM, Maltman N, Bush L, Cook EH, Davis LK, Losh M Biological psychiatry 33229037 Biol Psychiatry 2021 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/33229037
The Latent Genetic Structure of Impulsivity and Its Relation to Internalizing Psychopathology. Gustavson DE, Friedman NP, Fontanillas P, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S Psychological science 32716714 Psychol Sci 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32716714
New evidence of a rhythmic priming effect that enhances grammaticality judgments in children. Chern A, Tillmann B, Vaughan C, Gordon RL Journal of experimental child psychology 29778278 J Exp Child Psychol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/29778278
You got rhythm, or more: The multidimensionality of rhythmic abilities. Fiveash A, Bella SD, Bigand E, Gordon RL, Tillmann B Attention, perception & psychophysics 35437703 Atten Percept Psychophys 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35437703
The Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) Framework for Understanding Musicality-Language Links Across the Lifespan. Nayak S, Coleman PL, Ladányi E, Nitin R, Gustavson DE, Fisher SE, Magne CL, Gordon RL Neurobiology of language (Cambridge, Mass.) 36742012 Neurobiol Lang (Camb) 2022 https://www.ncbi.nlm.nih.gov/pubmed/36742012
Musical instrument engagement in adolescence predicts verbal ability 4 years later: A twin and adoption study. Gustavson DE, Friedman NP, Stallings MC, Reynolds CA, Coon H, Corley RP, Hewitt JK, Gordon RL Developmental psychology 34914455 Dev Psychol 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34914455
Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study. Gustavson DE, Coleman PL, Wang Y, Nitin R, Petty LE, Bush CT, Mosing MA, Wesseldijk LW, Ullén F, 23 and Me Research Team, Below JE, Cox NJ, Gordon RL Annals of the New York Academy of Sciences 36718543 Ann N Y Acad Sci 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36718543
The case for treatment fidelity in active music interventions: why and how. Wiens N, Gordon RL Annals of the New York Academy of Sciences 29727027 Ann N Y Acad Sci 2018 May 4 https://www.ncbi.nlm.nih.gov/pubmed/29727027
Regular rhythmic primes improve sentence repetition in children with developmental language disorder. Fiveash A, Ladányi E, Camici J, Chidiac K, Bush CT, Canette LH, Bedoin N, Gordon RL, Tillmann B NPJ science of learning 37429839 NPJ Sci Learn 2023 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/37429839
Individual differences in neural markers of beat processing relate to spoken grammar skills in six-year-old children. Persici V, Blain SD, Iversen JR, Key AP, Kotz SA, Devin McAuley J, Gordon RL Brain and language 37994830 Brain Lang 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37994830
Processing rhythm in speech and music: Shared mechanisms and implications for developmental speech and language disorders. Fiveash A, Bedoin N, Gordon RL, Tillmann B Neuropsychology 34435803 Neuropsychology 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34435803
Does rhythmic priming improve grammatical processing in Hungarian-speaking children with and without developmental language disorder? Ladányi E, Lukács Á, Gervain J Developmental science 34060171 Dev Sci 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34060171
Exploring individual differences in musical rhythm and grammar skills in school-aged children with typically developing language. Nitin R, Gustavson DE, Aaron AS, Boorom OA, Bush CT, Wiens N, Vaughan C, Persici V, Blain SD, Soman U, Hambrick DZ, Camarata SM, McAuley JD, Gordon RL Scientific reports 36750727 Sci Rep 2023 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/36750727
Polygenic Associations between Motor Behaviour, Neuromotor Traits, and Active Music Engagement in Four Cohorts. Henechowicz TL, Coleman PL, Gustavson DE, Mekki YN, Nayak S, Nitin R, Scartozzi AC, Tio ES, van Klei R, Felsky D, Thaut MH, Gordon RL bioRxiv : the preprint server for biology 40196524 bioRxiv 2025 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/40196524
GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging. Henechowicz T, Wolford B, Nitin R, Mekki Y, Scartozzi A, Coleman P, Tio E, Schlicht G, Nayak S, Thaut M, Felsky D, Gordon R Research square 41646368 Res Sq 2026 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/41646368
Using a polygenic score in a family design to understand genetic influences on musicality. Wesseldijk LW, Abdellaoui A, Gordon RL, 23andMe Research Team, Ullén F, Mosing MA Scientific reports 36038631 Sci Rep 2022 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/36038631
Mental health and music engagement: review, framework, and guidelines for future studies. Gustavson DE, Coleman PL, Iversen JR, Maes HH, Gordon RL, Lense MD Translational psychiatry 34226495 Transl Psychiatry 2021 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/34226495
Synaptic processes and immune-related pathways implicated in Tourette syndrome. Tsetsos F, Yu D, Sul JH, Huang AY, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau GA, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados MA, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Wagner M, Knowles JA, Jeremy Willsey A, Tischfield JA, Heiman GA, Cox NJ, Freimer NB, Neale BM, Davis LK, Coppola G, Mathews CA, Scharf JM, Paschou P, Tourette Association of America International Consortium for Genetics, Barr CL, Batterson JR, Berlin C, Budman CL, Cath DC, Coppola G, Cox NJ, Darrow S, Davis LK, Dion Y, Freimer NB, Grados MA, Greenberg E, Hirschtritt ME, Huang AY, Illmann C, King RA, Kurlan R, Leckman JF, Lyon GJ, Malaty IA, Mathews CA, McMahon WM, Neale BM, Okun MS, Osiecki L, Robertson MM, Rouleau GA, Sandor P, Scharf JM, Singer HS, Smit JH, Sul JH, Yu D, Gilles de la Tourette GWAS Replication Initiative, Aschauer HAH, Barta C, Budman CL, Cath DC, Depienne C, Hartmann A, Hebebrand J, Konstantinidis A, Mathews CA, Müller-Vahl K, Nagy P, Nöthen MM, Paschou P, Rizzo R, Rouleau GA, Sandor P, Scharf JM, Schlögelhofer M, Stamenkovic M, Stuhrmann M, Tsetsos F, Tarnok Z, Wolanczyk T, Worbe Y, Tourette International Collaborative Genetics Study, Brown L, Cheon KA, Coffey BJ, Dietrich A, Fernandez TV, Garcia-Delgar B, Gilbert D, Grice DE, Hagstrøm J, Hedderly T, Heiman GA, Heyman I, Hoekstra PJ, Huyser C, Kim YK, Kim YS, King RA, Koh YJ, Kook S, Kuperman S, Leventhal BL, Madruga-Garrido M, Mir P, Morer A, Münchau A, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Tischfield JA, Willsey AJ, Zinner S, Psychiatric Genomics Consortium Tourette Syndrome Working Group, Aschauer H, Barr CL, Barta C, Batterson JR, Berlin C, Brown L, Budman CL, Cath DC, Coffey BJ, Coppola G, Cox NJ, Darrow S, Davis LK, Depienne C, Dietrich A, Dion Y, Fernandez T, Freimer NB, Gilbert D, Grados MA, Greenberg E, Hartmann A, Hebebrand J, Heiman G, Hirschtritt ME, Hoekstra P, Huang AY, Illmann C, Jankovic J, King RA, Kuperman S, Lee PC, Lyon GJ, Malaty IA, Mathews CA, McMahon WM, Müller-Vahl K, Nagy P, Neale BM, Nöthen MM, Okun MS, Osiecki L, Paschou P, Rizzo R, Robertson MM, Rouleau GA, Sandor P, Scharf JM, Schlögelhofer M, Singer HS, Stamenkovic M, Stuhrmann M, Sul JH, Tarnok Z, Tischfield J, Tsetsos F, Willsey AJ, Woods D, Worbe Y, Yu D, Zinner S Translational psychiatry 33462189 Transl Psychiatry 2021 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/33462189
Infants' neural speech discrimination predicts individual differences in grammar ability at 6 years of age and their risk of developing speech-language disorders. Zhao TC, Boorom O, Kuhl PK, Gordon R Developmental cognitive neuroscience 33823366 Dev Cogn Neurosci 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33823366
Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. Smit DJA, Andreassen OA, Boomsma DI, Burwell SJ, Chorlian DB, de Geus EJC, Elvsåshagen T, Gordon RL, Harper J, Hegerl U, Hensch T, Iacono WG, Jawinski P, Jönsson EG, Luykx JJ, Magne CL, Malone SM, Medland SE, Meyers JL, Moberget T, Porjesz B, Sander C, Sisodiya SM, Thompson PM, van Beijsterveldt CEM, van Dellen E, Via M, Wright MJ Brain and behavior 34291596 Brain Behav 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34291596
The shared genetic architecture and evolution of human language and musical rhythm. Alagöz G, Eising E, Mekki Y, Bignardi G, Fontanillas P, 23andMe Research Team, Nivard MG, Luciano M, Cox NJ, Fisher SE, Gordon RL Nature human behaviour 39572686 Nat Hum Behav 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39572686
Confronting ethical and social issues related to the genetics of musicality. Gordon RL, Martschenko DO, Nayak S, Niarchou M, Morrison MD, Bell E, Jacoby N, Davis LK Annals of the New York Academy of Sciences 36851882 Ann N Y Acad Sci 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36851882
Targeted Rediscovery and Biosynthesis of the Farnesyl-Transferase Inhibitor Pepticinnamin E. Santa Maria KC, Chan AN, O'Neill EM, Li B Chembiochem : a European journal of chemical biology 30694017 Chembiochem 2019 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/30694017
Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa. Patteson JB, Putz AT, Tao L, Simke WC, Bryant LH 3rd, Britt RD, Li B Science (New York, N.Y.) 34793213 Science 2021 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/34793213
Purification and characterization of tomato arginine decarboxylase and its inhibition by the bacterial small molecule phevamine A. Guo Q, Chen X, Li B Protein expression and purification 37348664 Protein Expr Purif 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37348664
Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. Johnson RA, Chan AN, Ward RD, McGlade CA, Hatfield BM, Peters JM, Li B Journal of the American Chemical Society 34342433 J Am Chem Soc 2021 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/34342433
Specificity of Nonribosomal Peptide Synthetases in the Biosynthesis of the Pseudomonas virulence factor. Morgan GL, Kretsch AM, Santa Maria KC, Weeks SJ, Li B Biochemistry 31243997 Biochemistry 2019 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/31243997
Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas. Kretsch AM, Morgan GL, Tyrrell J, Mevers E, Vallet-Gély I, Li B Organic letters 30073838 Org Lett 2018 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/30073838
Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in Pseudomonas aeruginosa. Patteson JB, Lescallette AR, Li B Organic letters 31247735 Org Lett 2019 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/31247735
Chemoproteomics Reveals Disruption of Metal Homeostasis and Metalloproteins by the Antibiotic Holomycin. Chan AN, Chen X, Falco JA, Bak DW, Weerapana E, Li B ACS chemical biology 37561838 ACS Chem Biol 2023 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/37561838
A Permissive Amide N-Methyltransferase for Dithiolopyrrolones. Chen X, Johnson RM, Li B ACS catalysis 38106463 ACS Catal 2023 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/38106463
Analysis of Co-localized Biosynthetic Gene Clusters Identifies a Membrane-Permeabilizing Natural Product. Chen X, Li B Journal of natural products 38949271 J Nat Prod 2024 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/38949271
Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme. Simke WC, Walker ME, Calderone LA, Putz AT, Patteson JB, Vitro CN, Zizola CF, Redinbo MR, Pandelia ME, Grove TL, Li B ACS central science 39220707 ACS Cent Sci 2024 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/39220707
Pseudomonas Virulence Factor Pathway Synthesizes Autoinducers That Regulate the Secretome of a Pathogen. Kretsch AM, Morgan GL, Acken KA, Barr SA, Li B ACS chemical biology 33595276 ACS Chem Biol 2021 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/33595276
The Hybrid Antibiotic Thiomarinol A Overcomes Intrinsic Resistance in Escherichia coli Using a Privileged Dithiolopyrrolone Moiety. Johnson RM, Li K, Chen X, Morgan GL, Aubé J, Li B ACS infectious diseases 38226592 ACS Infect Dis 2024 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/38226592
Pseudomonas virulence factor controls expression of virulence genes in Pseudomonas entomophila. Acken KA, Li B PloS one 37200397 PLoS One 2023 https://www.ncbi.nlm.nih.gov/pubmed/37200397
In Vitro Reconstitution Reveals a Central Role for the N-Oxygenase PvfB in (Dihydro)pyrazine-N-oxide and Valdiazen Biosynthesis. Morgan GL, Li B Angewandte Chemie (International ed. in English) 32662921 Angew Chem Int Ed Engl 2020 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/32662921
Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase. Morgan GL, Li K, Crawford DM, Aubé J, Li B ACS chemical biology 34767712 ACS Chem Biol 2021 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/34767712
Activation of Dithiolopyrrolone Antibiotics by Cellular Reductants. Steiner OM, Johnson RA, Chen X, Simke WC, Li B Biochemistry 39665630 Biochemistry 2025 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/39665630
Parallel High-Resolution Imaging of Leukocyte Chemotaxis Under Agarose with Rho-Family GTPase Biosensors. Bell GRR, Natwick DE, Collins SR Methods in molecular biology (Clifton, N.J.) 30062406 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30062406
A map of gene expression in neutrophil-like cell lines. Rincón E, Rocha-Gregg BL, Collins SR BMC genomics 30068296 BMC Genomics 2018 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/30068296
Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology. Badu-Nkansah KA, Sernas D, Natwick DE, Collins SR Methods in molecular biology (Clifton, N.J.) 36227545 Methods Mol Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36227545
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors. Lundgren SM, Rocha-Gregg BL, Akdoğan E, Mysore MN, Hayes S, Collins SR Science signaling 37788324 Sci Signal 2023 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/37788324
Flagella-driven motility is a target of human Paneth cell defensin activity. Akahoshi DT, Natwick DE, Yuan W, Lu W, Collins SR, Bevins CL PLoS pathogens 36821624 PLoS Pathog 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36821624
Optimized iLID Membrane Anchors for Local Optogenetic Protein Recruitment. Natwick DE, Collins SR ACS synthetic biology 33843200 ACS Synth Biol 2021 May 21 https://www.ncbi.nlm.nih.gov/pubmed/33843200
Decoding GEFs of animated cells. Natwick DE, Collins SR Nature chemical biology 32694631 Nat Chem Biol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32694631
"Rho"ing a Cellular Boat with Rearward Membrane Flow. Bell GRR, Collins SR Developmental cell 29974859 Dev Cell 2018 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/29974859
Leading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration. Hadjitheodorou A, Bell GRR, Ellett F, Irimia D, Tibshirani R, Collins SR, Theriot JA Cell systems 36827986 Cell Syst 2023 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36827986
Parallel CRISPR screens reveal pathways controlling the cell surface levels of the attractant receptor FPR1. Akdoğan E, Lundgren SM, Kamber RA, Bassik MC, Collins SR Communications biology 41882347 Commun Biol 2026 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/41882347
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens. Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC Nature genetics 30397336 Nat Genet 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30397336
Neutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation. Bhakta SB, Lundgren SM, Sesti BN, Flores BA, Akdogan E, Collins SR, Mercer F PloS one 38324578 PLoS One 2024 https://www.ncbi.nlm.nih.gov/pubmed/38324578
Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity. Hadjitheodorou A, Bell GRR, Ellett F, Shastry S, Irimia D, Collins SR, Theriot JA Nature communications 34785640 Nat Commun 2021 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/34785640
Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes. Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Rixon JA, Mahan SP, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Bäumler AJ Cell host & microbe 35568027 Cell Host Microbe 2022 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/35568027
Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing. Bell GRR, Rincón E, Akdoğan E, Collins SR Nature communications 34785668 Nat Commun 2021 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/34785668
A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties. Dreyer CA, VanderVorst K, Natwick D, Bell G, Sood P, Hernandez M, Angelastro JM, Collins SR, Carraway KL 3rd Cancer letters 37336284 Cancer Lett 2023 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/37336284
Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Belliveau NM, Footer MJ, Akdoǧan E, van Loon AP, Collins SR, Theriot JA Nature communications 37723145 Nat Commun 2023 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/37723145
Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis. VanderVorst K, Dreyer CA, Hatakeyama J, Bell GRR, Learn JA, Berg AL, Hernandez M, Lee H, Collins SR, Carraway KL 3rd Breast cancer research : BCR 37147680 Breast Cancer Res 2023 May 5 https://www.ncbi.nlm.nih.gov/pubmed/37147680
Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene. Berrocal A, Lammers NC, Garcia HG, Eisen MB eLife 33300492 Elife 2020 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/33300492
Multimodal transcriptional control of pattern formation in embryonic development. Lammers NC, Galstyan V, Reimer A, Medin SA, Wiggins CH, Garcia HG Proceedings of the National Academy of Sciences of the United States of America 31882445 Proc Natl Acad Sci U S A 2020 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/31882445
Lighting up the central dogma for predictive developmental biology. Garcia HG, Berrocal A, Kim YJ, Martini G, Zhao J Current topics in developmental biology 32143740 Curr Top Dev Biol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32143740
DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins. Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BVL, Garcia HG, Qian SB, Brunkard JO, Roeder AHK Developmental cell 39305905 Dev Cell 2024 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/39305905
Quantitative imaging of RNA polymerase II activity in plants reveals the single-cell basis of tissue-wide transcriptional dynamics. Alamos S, Reimer A, Niyogi KK, Garcia HG Nature plants 34373604 Nat Plants 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34373604
The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output. Yamada S, Whitney PH, Huang SK, Eck EC, Garcia HG, Rushlow CA Current biology : CB 30982648 Curr Biol 2019 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/30982648
Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression. Phillips R, Belliveau NM, Chure G, Garcia HG, Razo-Mejia M, Scholes C Annual review of biophysics 31084583 Annu Rev Biophys 2019 May 6 https://www.ncbi.nlm.nih.gov/pubmed/31084583
Genetically Encoded Fluorescent Biosensor for Rapid Detection of Protein Expression. Eason MG, Pandelieva AT, Mayer MM, Khan ST, Garcia HG, Chica RA ACS synthetic biology 33044070 ACS Synth Biol 2020 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/33044070
Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility. Eck E, Liu J, Kazemzadeh-Atoufi M, Ghoreishi S, Blythe SA, Garcia HG eLife 33074101 Elife 2020 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/33074101
Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling. Falo-Sanjuan J, Lammers NC, Garcia HG, Bray SJ Developmental cell 31378591 Dev Cell 2019 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/31378591
Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer. Kim YJ, Rhee K, Liu J, Jeammet S, Turner MA, Small SJ, Garcia HG eLife 36503705 Elife 2022 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/36503705
Competing constraints shape the nonequilibrium limits of cellular decision-making. Lammers NC, Flamholz AI, Garcia HG Proceedings of the National Academy of Sciences of the United States of America 36862689 Proc Natl Acad Sci U S A 2023 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/36862689
LlamaTags: A Versatile Tool to Image Transcription Factor Dynamics in Live Embryos. Bothma JP, Norstad MR, Alamos S, Garcia HG Cell 29754814 Cell 2018 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/29754814
Real-time single-cell characterization of the eukaryotic transcription cycle reveals correlations between RNA initiation, elongation, and cleavage. Liu J, Hansen D, Eck E, Kim YJ, Turner M, Alamos S, Garcia HG PLoS computational biology 34003867 PLoS Comput Biol 2021 May https://www.ncbi.nlm.nih.gov/pubmed/34003867
Chromatin Changes in Phytochrome Interacting Factor-Regulated Genes Parallel Their Rapid Transcriptional Response to Light. González-Grandío E, Álamos S, Zhang Y, Dalton-Roesler J, Niyogi KK, García HG, Quail PH Frontiers in plant science 35251080 Front Plant Sci 2022 https://www.ncbi.nlm.nih.gov/pubmed/35251080
Single cell biology-a Keystone Symposia report. Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, Guilliams M, Alon U, Shalek AK, Hamel R, Pfau SJ, Raj A, Quake SR, Zhang NR, Fan J, Trapnell C, Wang B, Greenwald NF, Vento-Tormo R, Santos SDM, Spencer SL, Garcia HG, Arekatla G, Gaiti F, Arbel-Goren R, Rulands S, Junker JP, Klein AM, Morris SA, Murray JI, Galloway KE, Ratz M, Romeike M Annals of the New York Academy of Sciences 34605044 Ann N Y Acad Sci 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34605044
Minimal synthetic enhancers reveal control of the probability of transcriptional engagement and its timing by a morphogen gradient. Alamos S, Reimer A, Westrum C, Turner MA, Talledo P, Zhao J, Luu E, Garcia HG Cell systems 36696901 Cell Syst 2023 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/36696901
Single Molecule Imaging in Live Embryos Using Lattice Light-Sheet Microscopy. Mir M, Reimer A, Stadler M, Tangara A, Hansen AS, Hockemeyer D, Eisen MB, Garcia H, Darzacq X Methods in molecular biology (Clifton, N.J.) 29956254 Methods Mol Biol 2018 https://www.ncbi.nlm.nih.gov/pubmed/29956254
A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting. Lammers NC, Kim YJ, Zhao J, Garcia HG Current opinion in cell biology 33242838 Curr Opin Cell Biol 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33242838
Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila. Child MB 6th, Bateman JR, Jahangiri A, Reimer A, Lammers NC, Sabouni N, Villamarin D, McKenzie-Smith GC, Johnson JE, Jost D, Garcia HG eLife 34100718 Elife 2021 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/34100718
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq. Green CD, Ma Q, Manske GL, Shami AN, Zheng X, Marini S, Moritz L, Sultan C, Gurczynski SJ, Moore BB, Tallquist MD, Li JZ, Hammoud SS Developmental cell 30146481 Dev Cell 2018 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/30146481
TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Shen YC, Shami AN, Moritz L, Larose H, Manske GL, Ma Q, Zheng X, Sukhwani M, Czerwinski M, Sultan C, Chen H, Gurczynski SJ, Spence JR, Orwig KE, Tallquist M, Li JZ, Hammoud SS Nature communications 34162856 Nat Commun 2021 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/34162856
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline. Graniel JV, Bisht K, Friedman A, White J, Perkey E, Vanderbeck A, Moroz A, Carrington LJ, Brandstadter JD, Allen F, Shami AN, Thomas P, Crayton A, Manzor M, Mychalowych A, Chase J, Hammoud SS, Keegan CE, Maillard I, Nandakumar J Life science alliance 34645668 Life Sci Alliance 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34645668
Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation. Tower CA, Manske G, Ferrell EL, Anbarci DN, Jorgensen K, Ma B, Aboelenain M, Ranjan R, Chakraborty S, Moritz L, Das A, Boiani M, Black BE, Chavez S, Marsh EE, Shikanov A, Schindler K, Chen X, Hammoud SS bioRxiv : the preprint server for biology 40766472 bioRxiv 2025 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/40766472
Proteomic analysis of human sperm reveals changes in protamine 1 phosphorylation in men with infertility. Schon SB, Moritz L, Rabbani M, Meguid J, Juliano BR, Ruotolo BT, Aston K, Hammoud SS F&S science 38065301 F S Sci 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38065301
Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis. Shami AN, Zheng X, Munyoki SK, Ma Q, Manske GL, Green CD, Sukhwani M, Orwig KE, Li JZ, Hammoud SS Developmental cell 32504559 Dev Cell 2020 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/32504559
Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq. Ulrich ND, Shen YC, Ma Q, Yang K, Hannum DF, Jones A, Machlin J, Randolph JF Jr, Smith YR, Schon SB, Shikanov A, Marsh EE, Lieberman R, Gurczynski SJ, Moore BB, Li JZ, Hammoud S Developmental cell 35320732 Dev Cell 2022 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/35320732
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1. Moritz L, Schon SB, Rabbani M, Sheng Y, Agrawal R, Glass-Klaiber J, Sultan C, Camarillo JM, Clements J, Baldwin MR, Diehl AG, Boyle AP, O'Brien PJ, Ragunathan K, Hu YC, Kelleher NL, Nandakumar J, Li JZ, Orwig KE, Redding S, Hammoud SS Nature structural & molecular biology 37460896 Nat Struct Mol Biol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37460896
Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation. Tower CA, Manske G, Ferrell EL, Anbarci DN, Jorgensen K, Ma B, Aboelenain M, Ranjan R, Chakraborty S, Moritz L, Das A, Boiani M, Black BE, Chavez S, Marsh EE, Shikanov A, Schindler K, Chen X, Hammoud SS Developmental cell 40997799 Dev Cell 2026 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/40997799
Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. Grill S, Bisht K, Tesmer VM, Shami AN, Hammoud SS, Nandakumar J Cell reports 31216472 Cell Rep 2019 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/31216472
The Art of Packaging the Sperm Genome: Molecular and Structural Basis of the Histone-To-Protamine Exchange. Moritz L, Hammoud SS Frontiers in endocrinology 35813619 Front Endocrinol (Lausanne) 2022 https://www.ncbi.nlm.nih.gov/pubmed/35813619
Decoding the Spermatogenesis Program: New Insights from Transcriptomic Analyses. Rabbani M, Zheng X, Manske GL, Vargo A, Shami AN, Li JZ, Hammoud SS Annual review of genetics 36070560 Annu Rev Genet 2022 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/36070560
Regulation of meiotic progression by Sertoli-cell androgen signaling. Larose H, Kent T, Ma Q, Shami AN, Harerimana N, Li JZ, Hammoud SS, Handel MA Molecular biology of the cell 33026960 Mol Biol Cell 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/33026960
Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women. Ulrich ND, Vargo A, Ma Q, Shen YC, Bazzano D, Hannum DF, Gurczynski SJ, Moore BB, Schon S, Lieberman R, Shikanov A, Marsh EE, Fazleabas A, Li JZ, Hammoud SS Proceedings of the National Academy of Sciences of the United States of America 39471215 Proc Natl Acad Sci U S A 2024 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/39471215
Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells. Ma B, Yang G, Yao J, Wu C, Vega JP, Manske G, Hammoud SS, Sinha S, Singh A, Zhao H, Chen X bioRxiv : the preprint server for biology 40093102 bioRxiv 2025 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/40093102
ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements. Xie W, Gowder M, Bazzano D, Shami AN, Pandey A, Frasca M, Paniker L, de Almeida LP, Bharati BK, Liang J, Tóth A, DeSantis M, Nandakumar J, Nudler E, Mosalaganti S, Pezza R, Cole F, Hammoud SS bioRxiv : the preprint server for biology 41676639 bioRxiv 2026 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/41676639
Rapid DNA replication origin licensing protects stem cell pluripotency. Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG eLife 29148972 Elife 2017 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/29148972
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. Kumar RJ, Chao HX, Simpson DA, Feng W, Cho MG, Roberts VR, Sullivan AR, Shah SJ, Wozny AS, Fagan-Solis K, Kumar S, Luthman A, Ramsden DA, Purvis JE, Gupta GP NAR cancer 33385162 NAR Cancer 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33385162
The structure of the human cell cycle. Stallaert W, Kedziora KM, Taylor CD, Zikry TM, Ranek JS, Sobon HK, Taylor SR, Young CL, Cook JG, Purvis JE Cell systems 35051372 Cell Syst 2022 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/35051372
The consequences of differential origin licensing dynamics in distinct chromatin environments. Mei L, Kedziora KM, Song EA, Purvis JE, Cook JG Nucleic acids research 35079814 Nucleic Acids Res 2022 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/35079814
Inheritance of OCT4 predetermines fate choice in human embryonic stem cells. Wolff SC, Kedziora KM, Dumitru R, Dungee CD, Zikry TM, Beltran AS, Haggerty RA, Cheng J, Redick MA, Purvis JE Molecular systems biology 30177503 Mol Syst Biol 2018 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/30177503
Bistable switches as integrators and actuators during cell cycle progression. Stallaert W, Kedziora KM, Chao HX, Purvis JE FEBS letters 31566708 FEBS Lett 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31566708
Natural language processing: put your model where your mouth is. Haggerty RA, Purvis JE Molecular systems biology 29254950 Mol Syst Biol 2017 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/29254950
The structure of the human cell cycle. Stallaert W, Kedziora KM, Taylor CD, Zikry TM, Ranek JS, Sobon HK, Taylor SR, Young CL, Cook JG, Purvis JE Cell systems 34800361 Cell Syst 2022 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/34800361
Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction. Ranek JS, Stanley N, Purvis JE Genome biology 36064614 Genome Biol 2022 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/36064614
Evidence that the human cell cycle is a series of uncoupled, memoryless phases. Chao HX, Fakhreddin RI, Shimerov HK, Kedziora KM, Kumar RJ, Perez J, Limas JC, Grant GD, Cook JG, Gupta GP, Purvis JE Molecular systems biology 30886052 Mol Syst Biol 2019 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/30886052
The Cell Cycle Browser: An Interactive Tool for Visualizing, Simulating, and Perturbing Cell-Cycle Progression. Borland D, Yi H, Grant GD, Kedziora KM, Chao HX, Haggerty RA, Kumar J, Wolff SC, Cook JG, Purvis JE Cell systems 30077635 Cell Syst 2018 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/30077635
Genetic determinants of cellular addiction to DNA polymerase theta. Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP Nature communications 31537809 Nat Commun 2019 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/31537809
Autophagy regulates the localization and degradation of p16(INK4a). Coryell PR, Goraya SK, Griffin KA, Redick MA, Sisk SR, Purvis JE Aging cell 32662244 Aging Cell 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32662244
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics. Burclaff J, Bliton RJ, Breau KA, Ok MT, Gomez-Martinez I, Ranek JS, Bhatt AP, Purvis JE, Woosley JT, Magness ST Cellular and molecular gastroenterology and hepatology 35176508 Cell Mol Gastroenterol Hepatol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35176508
Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Enrico TP, Stallaert W, Wick ET, Ngoi P, Wang X, Rubin SM, Brown NG, Purvis JE, Emanuele MJ eLife 34851822 Elife 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/34851822
Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle. Chao HX, Poovey CE, Privette AA, Grant GD, Chao HY, Cook JG, Purvis JE Cell systems 29102360 Cell Syst 2017 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/29102360
Accurate delineation of cell cycle phase transitions in living cells with PIP-FUCCI. Grant GD, Kedziora KM, Limas JC, Cook JG, Purvis JE Cell cycle (Georgetown, Tex.) 30421640 Cell Cycle 2018 https://www.ncbi.nlm.nih.gov/pubmed/30421640
Chemical screen for epigenetic barriers to single allele activation of Oct4. Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA Stem cell research 31170660 Stem Cell Res 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31170660
Inferring the structures of signaling motifs from paired dynamic traces of single cells. Haggerty RA, Purvis JE PLoS computational biology 33539338 PLoS Comput Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33539338
Dynamics of the HIV outbreak and response in Scott County, IN, USA, 2011-15: a modelling study. Gonsalves GS, Crawford FW The lancet. HIV 30220531 Lancet HIV 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30220531
An Adaptive Approach to Locating Mobile HIV Testing Services. Gonsalves GS, Crawford FW, Cleary PD, Kaplan EH, Paltiel AD Medical decision making : an international journal of the Society for Medical Decision Making 28699382 Med Decis Making 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/28699382
Transmission Modeling with Regression Adjustment for Analyzing Household-based Studies of Infectious Disease: Application to Tuberculosis. Crawford FW, Marx FM, Zelner J, Cohen T Epidemiology (Cambridge, Mass.) 31764276 Epidemiology 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31764276
Cost-effectiveness of expanding the capacity of opioid agonist treatment in Ukraine: dynamic modeling analysis. Morozova O, Crawford FW, Cohen T, Paltiel AD, Altice FL Addiction (Abingdon, England) 31478285 Addiction 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/31478285
SARS-CoV-2 attack rate and population immunity in southern New England, March 2020 - May 2021. Tran TN, Wikle NB, Yang F, Inam H, Leighow S, Gentilesco B, Chan P, Albert E, Strong ER, Pritchard JR, Hanage WP, Hanks EM, Crawford FW, Boni MF medRxiv : the preprint server for health sciences 34909789 medRxiv 2021 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/34909789
Randomized controlled trials of biomarker targets. Erlendsdottir M, Crawford FW Clinical trials (London, England) 36373783 Clin Trials 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/36373783
Impact of close interpersonal contact on COVID-19 incidence: Evidence from 1 year of mobile device data. Crawford FW, Jones SA, Cartter M, Dean SG, Warren JL, Li ZR, Barbieri J, Campbell J, Kenney P, Valleau T, Morozova O Science advances 34995121 Sci Adv 2022 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/34995121
Dependence-Robust Confidence Intervals for Capture-Recapture Surveys. Sun J, Van Baelen L, Plettinckx E, Crawford FW Journal of survey statistics and methodology 37975066 J Surv Stat Methodol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37975066
Estimating the early death toll of COVID-19 in the United States. Weinberger DM, Cohen T, Crawford FW, Mostashari F, Olson D, Pitzer VE, Reich NG, Russi M, Simonsen L, Watkins A, Viboud C medRxiv : the preprint server for health sciences 32511293 medRxiv 2020 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/32511293
Violence and Discrimination Against Men Who Have Sex With Men in Lebanon: The Role of International Displacement and Migration. Orr L, Shebl FM, Heimer R, Khoshnood K, Barbour R, Khouri D, Aaraj E, Mokhbat JE, Crawford FW Journal of interpersonal violence 31658847 J Interpers Violence 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/31658847
Interpretation of the Individual Effect Under Treatment Spillover. Crawford FW, Morozova O, Buchanan AL, Spiegelman D American journal of epidemiology 31094425 Am J Epidemiol 2019 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/31094425
Estimates of people who injected drugs within the last 12 months in Belgium based on a capture-recapture and multiplier method. Plettinckx E, Crawford FW, Antoine J, Gremeaux L, Van Baelen L Drug and alcohol dependence 33310486 Drug Alcohol Depend 2021 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/33310486
Estimating dose-specific cell division and apoptosis rates from chemo-sensitivity experiments. Liu Y, Crawford FW Scientific reports 29426887 Sci Rep 2018 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/29426887
Opioid Agonist Treatment and Improved Outcomes at Each Stage of the HIV Treatment Cascade in People Who Inject Drugs in Ukraine. Mazhnaya A, Marcus R, Bojko MJ, Zelenev A, Makarenko I, Pykalo I, Filippovych S, Dvoriak S, Altice FL Journal of acquired immune deficiency syndromes (1999) 30312275 J Acquir Immune Defic Syndr 2018 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/30312275
Empirical evidence of recruitment bias in a network study of people who inject drugs. Zeng L, Li J, Crawford FW The American journal of drug and alcohol abuse 30896982 Am J Drug Alcohol Abuse 2019 https://www.ncbi.nlm.nih.gov/pubmed/30896982
Exposure, hazard, and survival analysis of diffusion on social networks. Wu J, Crawford FW, Kim DA, Stafford D, Christakis NA Statistics in medicine 29707798 Stat Med 2018 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/29707798
Estimating the Size of a Large Network and its Communities from a Random Sample. Chen L, Karbasi A, Crawford FW Advances in neural information processing systems 28867924 Adv Neural Inf Process Syst 2016 https://www.ncbi.nlm.nih.gov/pubmed/28867924
Computational methods for birth-death processes. Crawford FW, Ho LST, Suchard MA Wiley interdisciplinary reviews 29942419 Wiley Interdiscip Rev Comput Stat 2018 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/29942419
Risk ratios for contagious outcomes. Morozova O, Cohen T, Crawford FW Journal of the Royal Society, Interface 29343627 J R Soc Interface 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29343627
Evaluating the Mediating Role of Recall of Intervention Knowledge in the Relationship Between a Peer-Driven Intervention and HIV Risk Behaviors Among People Who Inject Drugs. Aroke H, Buchanan A, Katenka N, Crawford FW, Lee T, Halloran ME, Latkin C AIDS and behavior 35932359 AIDS Behav 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/35932359
Randomization for the susceptibility effect of an infectious disease intervention. Eck DJ, Morozova O, Crawford FW Journal of mathematical biology 36127558 J Math Biol 2022 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/36127558
Hidden population size estimation from respondent-driven sampling: a network approach. Crawford FW, Wu J, Heimer R Journal of the American Statistical Association 30828120 J Am Stat Assoc 2018 https://www.ncbi.nlm.nih.gov/pubmed/30828120
Predictors of Mortality within Prison and after Release among Persons Living with HIV in Indonesia. Culbert GJ, Crawford FW, Murni A, Waluyo A, Bazazi AR, Sahar J, Altice FL Research and reports in tropical medicine 29238241 Res Rep Trop Med 2017 https://www.ncbi.nlm.nih.gov/pubmed/29238241
The Burden of Stigma on Health and Well-Being: A Taxonomy of Concealment, Course, Disruptiveness, Aesthetics, Origin, and Peril Across 93 Stigmas. Pachankis JE, Hatzenbuehler ML, Wang K, Burton CL, Crawford FW, Phelan JC, Link BG Personality & social psychology bulletin 29290150 Pers Soc Psychol Bull 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29290150
Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis. Li ZR, Xie E, Crawford FW, Warren JL, McConnell K, Copple JT, Johnson T, Gonsalves GS PLoS medicine 31714940 PLoS Med 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31714940
HIV Testing and awareness of HIV status among people who inject drugs in greater Kuala Lumpur, Malaysia. Bazazi AR, Vijay A, Crawford FW, Heimer R, Kamarulzaman A, Altice FL AIDS care 28803503 AIDS Care 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28803503
Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks. Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V The New England journal of medicine 32242365 N Engl J Med 2020 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/32242365
One year of modeling and forecasting COVID-19 transmission to support policymakers in Connecticut. Morozova O, Li ZR, Crawford FW medRxiv : the preprint server for health sciences 32587978 medRxiv 2021 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/32587978
Using sigLASSO to optimize cancer mutation signatures jointly with sampling likelihood. Li S, Crawford FW, Gerstein MB Nature communications 32681003 Nat Commun 2020 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/32681003
Impact of close interpersonal contact on COVID-19 incidence: evidence from one year of mobile device data. Crawford FW, Jones SA, Cartter M, Dean SG, Warren JL, Li ZR, Barbieri J, Campbell J, Kenney P, Valleau T, Morozova O medRxiv : the preprint server for health sciences 33758869 medRxiv 2021 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/33758869
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE medRxiv : the preprint server for health sciences 34981074 medRxiv 2021 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/34981074
Identification of causal intervention effects under contagion. Cai X, Loh WW, Crawford FW Journal of causal inference 34676152 J Causal Inference 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/34676152
Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Prunas O, Warren JL, Crawford FW, Gazit S, Patalon T, Weinberger DM, Pitzer VE Science (New York, N.Y.) 35084937 Science 2022 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/35084937
Geographic and temporal trends in fentanyl-detected deaths in Connecticut, 2009-2019. Lu H, Crawford FW, Gonsalves GS, Grau LE Annals of epidemiology 36669599 Ann Epidemiol 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36669599
One year of modeling and forecasting COVID-19 transmission to support policymakers in Connecticut. Morozova O, Li ZR, Crawford FW Scientific reports 34642405 Sci Rep 2021 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/34642405
HIV Risk, Prevalence, and Access to Care Among Men Who Have Sex with Men in Lebanon. Heimer R, Barbour R, Khouri D, Crawford FW, Shebl F, Aaraj E, Khoshnood K AIDS research and human retroviruses 28540733 AIDS Res Hum Retroviruses 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28540733
Divergent estimates of HIV incidence among people who inject drugs in Ukraine. Morozova O, Booth RE, Dvoriak S, Dumchev K, Sazonova Y, Saliuk T, Crawford FW The International journal on drug policy 31405731 Int J Drug Policy 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31405731
COVID-19 projections for reopening Connecticut. Crawford FW, Li ZR, Morozova O medRxiv : the preprint server for health sciences 32588003 medRxiv 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32588003
Pentose Metabolism in Saccharomyces cerevisiae: The Need to Engineer Global Regulatory Systems. Endalur Gopinarayanan V, Nair NU Biotechnology journal 30171750 Biotechnol J 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30171750
Engineered lactobacilli display anti-biofilm and growth suppressing activities against Pseudomonas aeruginosa. Chappell TC, Nair NU NPJ biofilms and microbiomes 33127888 NPJ Biofilms Microbiomes 2020 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/33127888
Engineered antimicrobial-derived peptides to manipulate mixed microbial systems. Trivedi VD, Van Deventer JA, Nair NU bioRxiv : the preprint server for biology 41256581 bioRxiv 2025 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/41256581
Pharmacophore-driven antibody discovery on the yeast surface. Huang M, Williams SJ, Trivedi VD, Nair NU, Van Deventer JA bioRxiv : the preprint server for biology 41279963 bioRxiv 2025 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/41279963
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates. Trivedi VD, Sullivan SF, Choudhury D, Endalur Gopinarayanan V, Hart T, Nair NU Cell chemical biology 37421944 Cell Chem Biol 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37421944
Characterization of a membrane enzymatic complex for heterologous production of poly-γ-glutamate in E. coli. Motta Nascimento B, Nair NU Metabolic engineering communications 32963960 Metab Eng Commun 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/32963960
Establishing synthesis pathway-host compatibility via enzyme solubility. Amin SA, Endalur Gopinarayanan V, Nair NU, Hassoun S Biotechnology and bioengineering 30802311 Biotechnol Bioeng 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30802311
Towards creating an extended metabolic model (EMM) for E. coli using enzyme promiscuity prediction and metabolomics data. Amin SA, Chavez E, Porokhin V, Nair NU, Hassoun S Microbial cell factories 31196115 Microb Cell Fact 2019 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/31196115
Galactose to tagatose isomerization at moderate temperatures with high conversion and productivity. Bober JR, Nair NU Nature communications 31591402 Nat Commun 2019 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/31591402
Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications. Bober JR, Beisel CL, Nair NU Annual review of biomedical engineering 29528686 Annu Rev Biomed Eng 2018 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/29528686
A quantitative model for metabolic intervention using gut microbes. Mays ZJS, Nair NU Biotechnology progress 33426814 Biotechnol Prog 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33426814
In-depth Sequence-Function Characterization Reveals Multiple Pathways to Enhance Enzymatic Activity. Trivedi VD, Chappell TC, Krishna NB, Shetty A, Sigamani GG, Mohan K, Ramesh A, Pravin KR, Nair NU ACS catalysis 37325394 ACS Catal 2022 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/37325394
Specific codons control cellular resources and fitness. Love AM, Nair NU Science advances 38381824 Sci Adv 2024 Feb 23 https://www.ncbi.nlm.nih.gov/pubmed/38381824
Toward a genetic tool development pipeline for host-associated bacteria. Waller MC, Bober JR, Nair NU, Beisel CL Current opinion in microbiology 28624690 Curr Opin Microbiol 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28624690
Synthetic biology in probiotic lactic acid bacteria: At the frontier of living therapeutics. Mays ZJ, Nair NU Current opinion in biotechnology 29550614 Curr Opin Biotechnol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29550614
A semi-synthetic regulon enables rapid growth of yeast on xylose. Endalur Gopinarayanan V, Nair NU Nature communications 29581426 Nat Commun 2018 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/29581426
A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy. d'Amone L, Trivedi VD, Nair NU, Omenetto FG Molecular pharmaceutics 35862031 Mol Pharm 2022 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/35862031
Quantifying and Engineering Mucus Adhesion of Probiotics. Mays ZJS, Chappell TC, Nair NU ACS synthetic biology 31909976 ACS Synth Biol 2020 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/31909976
Directed evolution of Anabaena variabilis phenylalanine ammonia-lyase (PAL) identifies mutants with enhanced activities. Mays ZJ , Mohan K , Trivedi VD , Chappell TC , Nair NU Chemical communications (Cambridge, England) 32270162 Chem Commun (Camb) 2020 May 14 https://www.ncbi.nlm.nih.gov/pubmed/32270162
Analysis of metabolic network disruption in engineered microbial hosts due to enzyme promiscuity. Porokhin V, Amin SA, Nicks TB, Gopinarayanan VE, Nair NU, Hassoun S Metabolic engineering communications 33850714 Metab Eng Commun 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33850714
Cheating the Cheater: Suppressing False-Positive Enrichment during Biosensor-Guided Biocatalyst Engineering. Trivedi VD, Mohan K, Chappell TC, Mays ZJS, Nair NU ACS synthetic biology 34914365 ACS Synth Biol 2022 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/34914365
Towards universal synthetic heterotrophy using a metabolic coordinator. Sullivan SF, Shetty A, Bharadwaj T, Krishna N, Trivedi VD, Endalur Gopinarayanan V, Chappell TC, Sellers DM, Pravin Kumar R, Nair NU Metabolic engineering 37406763 Metab Eng 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37406763
Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics. Holt BA, Mac QD, Kwong GA Journal of visualized experiments : JoVE 30059042 J Vis Exp 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30059042
Synthetic biomarkers: a twenty-first century path to early cancer detection. Kwong GA, Ghosh S, Gamboa L, Patriotis C, Srivastava S, Bhatia SN Nature reviews. Cancer 34489588 Nat Rev Cancer 2021 Oct https://www.ncbi.nlm.nih.gov/pubmed/34489588
Dimensionless parameter predicts bacterial prodrug success. Holt BA, Tuttle M, Xu Y, Su M, Røise JJ, Wang X, Murthy N, Kwong GA Molecular systems biology 35005851 Mol Syst Biol 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/35005851
Macrophage Sensors for Early Cancer Detection. Kwong GA Clinical chemistry 32040571 Clin Chem 2020 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/32040571
Synthetic Antigen-Presenting Cells for Adoptive T Cell Therapy. Dahotre SN, Romanov AM, Su FY, Kwong GA Advanced therapeutics 34541300 Adv Ther (Weinh) 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34541300
In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles. Su FY, Zhao QH, Dahotre SN, Gamboa L, Bawage SS, Silva Trenkle AD, Zamat A, Phuengkham H, Ahmed R, Santangelo PJ, Kwong GA Science advances 35196075 Sci Adv 2022 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/35196075
Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens. Gamboa L, Zamat AH, Thiveaud CA, Lee HJ, Kulaksizoglu E, Zha Z, Campbell NS, Chan CS, Fábrega S, Oliver SA, Su FY, Phuengkham H, Vanover D, Peck HE, Sivakumar A, Dahotre SN, Harris AM, Santangelo PJ, Kwong GA Nature cancer 40379831 Nat Cancer 2025 Jun https://www.ncbi.nlm.nih.gov/pubmed/40379831
Embracing enzyme promiscuity with activity-based compressed biosensing. Holt BA, Lim HS, Sivakumar A, Phuengkham H, Su M, Tuttle M, Xu Y, Liakakos H, Qiu P, Kwong GA Cell reports methods 36814844 Cell Rep Methods 2023 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/36814844
AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity. Sivakumar A, Phuengkham H, Rajesh H, Mac QD, Rogers LC, Silva Trenkle AD, Bawage SS, Hincapie R, Li Z, Vainikos S, Lee I, Xue M, Qiu P, Finn MG, Kwong GA Nature nanotechnology 39753733 Nat Nanotechnol 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39753733
Protease-Activated Plasmonic Nanosensors for Predictive Ultrasound-Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy. Kim M, Song S, Zamat A, Pelkowski PS, Subramanian S, Cadena M, Fabrega S, Brienen M, Kim J, Kwong GA, Emelianov SY Advanced science (Weinheim, Baden-Wurttemberg, Germany) 41391042 Adv Sci (Weinh) 2026 Feb https://www.ncbi.nlm.nih.gov/pubmed/41391042
Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains. Miller IC, Gamboa Castro M, Maenza J, Weis JP, Kwong GA ACS synthetic biology 29579381 ACS Synth Biol 2018 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/29579381
Individually addressable and dynamic DNA gates for multiplexed cell sorting. Dahotre SN, Chang YM, Wieland A, Stammen SR, Kwong GA Proceedings of the National Academy of Sciences of the United States of America 29632190 Proc Natl Acad Sci U S A 2018 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/29632190
Synthetic immunity by remote control. Gamboa L, Zamat AH, Kwong GA Theranostics 32206114 Theranostics 2020 https://www.ncbi.nlm.nih.gov/pubmed/32206114
Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Miller IC, Zamat A, Sun LK, Phuengkham H, Harris AM, Gamboa L, Yang J, Murad JP, Priceman SJ, Kwong GA Nature biomedical engineering 34385695 Nat Biomed Eng 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34385695
Interfacing Biomaterials with Synthetic T Cell Immunity. Su FY, Mac QD, Sivakumar A, Kwong GA Advanced healthcare materials 33887123 Adv Healthc Mater 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33887123
Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors. Mac QD, Sivakumar A, Phuengkham H, Xu C, Bowen JR, Su FY, Stentz SZ, Sim H, Harris AM, Li TT, Qiu P, Kwong GA Nature biomedical engineering 35241815 Nat Biomed Eng 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35241815
Protease circuits for processing biological information. Holt BA, Kwong GA Nature communications 33024117 Nat Commun 2020 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/33024117
DNA-Barcoded pMHC Tetramers for Detection of Single Antigen-Specific T Cells by Digital PCR. Dahotre SN, Chang YM, Romanov AM, Kwong GA Analytical chemistry 30656939 Anal Chem 2019 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/30656939
Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity. Mac QD, Mathews DV, Kahla JA, Stoffers CM, Delmas OM, Holt BA, Adams AB, Kwong GA Nature biomedical engineering 30952979 Nat Biomed Eng 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30952979
Heat-Triggered Remote Control of CRISPR-dCas9 for Tunable Transcriptional Modulation. Gamboa L, Phung EV, Li H, Meyers JP, Hart AC, Miller IC, Kwong GA ACS chemical biology 31904924 ACS Chem Biol 2020 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/31904924
Deconvolving multiplexed protease signatures with substrate reduction and activity clustering. Zhuang Q, Holt BA, Kwong GA, Qiu P PLoS computational biology 31479443 PLoS Comput Biol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31479443
Sci-fate characterizes the dynamics of gene expression in single cells. Cao J, Zhou W, Steemers F, Trapnell C, Shendure J Nature biotechnology 32284584 Nat Biotechnol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32284584
High-throughput, microscope-based sorting to dissect cellular heterogeneity. Hasle N, Cooke A, Srivatsan S, Huang H, Stephany JJ, Krieger Z, Jackson D, Tang W, Pendyala S, Monnat RJ Jr, Trapnell C, Hatch EM, Fowler DM Molecular systems biology 32500953 Mol Syst Biol 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32500953
Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation. Packer J, Trapnell C Trends in genetics : TIG 30007833 Trends Genet 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30007833
Reversed graph embedding resolves complex single-cell trajectories. Qiu X, Mao Q, Tang Y, Wang L, Chawla R, Pliner HA, Trapnell C Nature methods 28825705 Nat Methods 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28825705
The single-cell transcriptional landscape of mammalian organogenesis. Cao J, Spielmann M, Qiu X, Huang X, Ibrahim DM, Hill AJ, Zhang F, Mundlos S, Christiansen L, Steemers FJ, Trapnell C, Shendure J Nature 30787437 Nature 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30787437
Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, Engquist EN, Trapnell C, Gifford DK, Melton DA Cell reports 31116975 Cell Rep 2019 May 21 https://www.ncbi.nlm.nih.gov/pubmed/31116975
MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays. Rubin AF, Stone J, Bianchi AH, Capodanno BJ, Da EY, Dias M, Esposito D, Frazer J, Fu Y, Grindstaff SB, Harrington MR, Li I, McEwen AE, Min JK, Moore N, Moscatelli OG, Ong J, Polunina PV, Rollins JE, Rollins NJ, Snyder AE, Tam A, Wakefield MJ, Ye SS, Starita LM, Bryant VL, Marks DS, Fowler DM Genome biology 39838450 Genome Biol 2025 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/39838450
Defining cell types and states with single-cell genomics. Trapnell C Genome research 26430159 Genome Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26430159
Single-cell transcriptome sequencing: recent advances and remaining challenges. Liu S, Trapnell C F1000Research 26949524 F1000Res 2016 https://www.ncbi.nlm.nih.gov/pubmed/26949524
IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer. Furlan SN, Singh K, Lopez C, Tkachev V, Hunt DJ, Hibbard J, Betz KM, Blazar BR, Trapnell C, Kean LS Blood advances 32311015 Blood Adv 2020 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/32311015
Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe. Qiu X, Rahimzamani A, Wang L, Ren B, Mao Q, Durham T, McFaline-Figueroa JL, Saunders L, Trapnell C, Kannan S Cell systems 32135093 Cell Syst 2020 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/32135093
Massively multiplex chemical transcriptomics at single-cell resolution. Srivatsan SR, McFaline-Figueroa JL, Ramani V, Saunders L, Cao J, Packer J, Pliner HA, Jackson DL, Daza RM, Christiansen L, Zhang F, Steemers F, Shendure J, Trapnell C Science (New York, N.Y.) 31806696 Science 2020 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/31806696
Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. Saunders LM, Mishra AK, Aman AJ, Lewis VM, Toomey MB, Packer JS, Qiu X, McFaline-Figueroa JL, Corbo JC, Trapnell C, Parichy DM eLife 31140974 Elife 2019 May 29 https://www.ncbi.nlm.nih.gov/pubmed/31140974
Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation. Wray-Dutra MN, Chawla R, Thomas KR, Seymour BJ, Arkatkar T, Sommer KM, Khim S, Trapnell C, James RG, Rawlings DJ The Journal of experimental medicine 30127060 J Exp Med 2018 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/30127060
Joint profiling of chromatin accessibility and gene expression in thousands of single cells. Cao J, Cusanovich DA, Ramani V, Aghamirzaie D, Pliner HA, Hill AJ, Daza RM, McFaline-Figueroa JL, Packer JS, Christiansen L, Steemers FJ, Adey AC, Trapnell C, Shendure J Science (New York, N.Y.) 30166440 Science 2018 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/30166440
Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana. Jean-Baptiste K, McFaline-Figueroa JL, Alexandre CM, Dorrity MW, Saunders L, Bubb KL, Trapnell C, Fields S, Queitsch C, Cuperus JT The Plant cell 30923229 Plant Cell 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30923229
Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome. Cacchiarelli D, Qiu X, Srivatsan S, Manfredi A, Ziller M, Overbey E, Grimaldi A, Grimsby J, Pokharel P, Livak KJ, Li S, Meissner A, Mikkelsen TS, Rinn JL, Trapnell C Cell systems 30195438 Cell Syst 2018 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/30195438
Single-cell mRNA quantification and differential analysis with Census. Qiu X, Hill A, Packer J, Lin D, Ma YA, Trapnell C Nature methods 28114287 Nat Methods 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28114287
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy. McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C Cell genomics 38278156 Cell Genom 2024 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/38278156
Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis. Hanchate NK, Kondoh K, Lu Z, Kuang D, Ye X, Qiu X, Pachter L, Trapnell C, Buck LB Science (New York, N.Y.) 26541607 Science 2015 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/26541607
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets. Sharon N, Chawla R, Mueller J, Vanderhooft J, Whitehorn LJ, Rosenthal B, Gürtler M, Estanboulieh RR, Shvartsman D, Gifford DK, Trapnell C, Melton D Cell 30661759 Cell 2019 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/30661759
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice. Mucci A, Lopez-Rodriguez E, Hetzel M, Liu S, Suzuki T, Happle C, Ackermann M, Kempf H, Hillje R, Kunkiel J, Janosz E, Brennig S, Glage S, Bankstahl JP, Dettmer S, Rodt T, Gohring G, Trapnell B, Hansen G, Trapnell C, Knudsen L, Lachmann N, Moritz T Stem cell reports 30100408 Stem Cell Reports 2018 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/30100408
Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data. Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C Molecular cell 30078726 Mol Cell 2018 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/30078726
A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility. Cusanovich DA, Hill AJ, Aghamirzaie D, Daza RM, Pliner HA, Berletch JB, Filippova GN, Huang X, Christiansen L, DeWitt WS, Lee C, Regalado SG, Read DF, Steemers FJ, Disteche CM, Trapnell C, Shendure J Cell 30078704 Cell 2018 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/30078704
Supervised classification enables rapid annotation of cell atlases. Pliner HA, Shendure J, Trapnell C Nature methods 31501545 Nat Methods 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31501545
Comprehensive single-cell transcriptional profiling of a multicellular organism. Cao J, Packer JS, Ramani V, Cusanovich DA, Huynh C, Daza R, Qiu X, Lee C, Furlan SN, Steemers FJ, Adey A, Waterston RH, Trapnell C, Shendure J Science (New York, N.Y.) 28818938 Science 2017 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/28818938
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface. Gabrovsek L, Collins KB, Aggarwal S, Saunders LM, Lau HT, Suh D, Sancak Y, Trapnell C, Ong SE, Smith FD, Scott JD The Journal of biological chemistry 32482893 J Biol Chem 2020 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/32482893
Dimensionality reduction by UMAP to visualize physical and genetic interactions. Dorrity MW, Saunders LM, Queitsch C, Fields S, Trapnell C Nature communications 32210240 Nat Commun 2020 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/32210240
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy. McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C bioRxiv : the preprint server for biology 37398090 bioRxiv 2023 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/37398090
On the design of CRISPR-based single-cell molecular screens. Hill AJ, McFaline-Figueroa JL, Starita LM, Gasperini MJ, Matreyek KA, Packer J, Jackson D, Shendure J, Trapnell C Nature methods 29457792 Nat Methods 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29457792
The accessible chromatin landscape of the murine hippocampus at single-cell resolution. Sinnamon JR, Torkenczy KA, Linhoff MW, Vitak SA, Mulqueen RM, Pliner HA, Trapnell C, Steemers FJ, Mandel G, Adey AC Genome research 30936163 Genome Res 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30936163
A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition. McFaline-Figueroa JL, Hill AJ, Qiu X, Jackson D, Shendure J, Trapnell C Nature genetics 31477929 Nat Genet 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31477929
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution. Packer JS, Zhu Q, Huynh C, Sivaramakrishnan P, Preston E, Dueck H, Stefanik D, Tan K, Trapnell C, Kim J, Waterston RH, Murray JI Science (New York, N.Y.) 31488706 Science 2019 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/31488706
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens. Gasperini M, Hill AJ, McFaline-Figueroa JL, Martin B, Kim S, Zhang MD, Jackson D, Leith A, Schreiber J, Noble WS, Trapnell C, Ahituv N, Shendure J Cell 30612741 Cell 2019 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/30612741
Connect-seq to superimpose molecular on anatomical neural circuit maps. Hanchate NK, Lee EJ, Ellis A, Kondoh K, Kuang D, Basom R, Trapnell C, Buck LB Proceedings of the National Academy of Sciences of the United States of America 32034095 Proc Natl Acad Sci U S A 2020 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/32034095
Compartmentalized dynamics within a common multi-area mesoscale manifold represent a repertoire of human hand movements. Natraj N, Silversmith DB, Chang EF, Ganguly K Neuron 34678147 Neuron 2022 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/34678147
Plug-and-play control of a brain-computer interface through neural map stabilization. Silversmith DB, Abiri R, Hardy NF, Natraj N, Tu-Chan A, Chang EF, Ganguly K Nature biotechnology 32895549 Nat Biotechnol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/32895549
Sampling representational plasticity of simple imagined movements across days enables long-term neuroprosthetic control. Natraj N, Seko S, Abiri R, Miao R, Yan H, Graham Y, Tu-Chan A, Chang EF, Ganguly K Cell 40054446 Cell 2025 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/40054446
Cortical neuroprosthetics from a clinical perspective. Tsu AP, Burish MJ, GodLove J, Ganguly K Neurobiology of disease 26253606 Neurobiol Dis 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26253606
Muscle synergies after stroke are correlated with perilesional high gamma. Godlove J, Gulati T, Dichter B, Chang E, Ganguly K Annals of clinical and translational neurology 28097208 Ann Clin Transl Neurol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/28097208
Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control. Natraj N, Seko S, Abiri R, Yan H, Graham Y, Tu-Chan A, Chang EF, Ganguly K bioRxiv : the preprint server for biology 37645922 bioRxiv 2023 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/37645922
Biologically Derived Neoproteoglycans for Profiling Protein-Glycosaminoglycan Interactions. Porell RN, Follmar JL, Purcell SC, Timm B, Laubach LK, Kozirovskiy D, Thacker BE, Glass CA, Gordts PLSM, Godula K ACS chemical biology 35574759 ACS Chem Biol 2022 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/35574759
Cell surface photoengineering enables modeling of glycocalyx shedding dynamics. Purcell SC, Zhang MH, Honigfort DJ, Ng HJC, Michalak AL, Godula K Chemical science 35756522 Chem Sci 2022 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/35756522
Following sugar patterns in search of galectin function. Godula K Proceedings of the National Academy of Sciences of the United States of America 29496962 Proc Natl Acad Sci U S A 2018 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/29496962
DNA Aptamer-Guided Glycomimetics for Developmental Stage-Specific Glycocalyx Engineering to Control Stem Cell Differentiation. Purcell SC, Naticchia MR, Follmar JL, Marroquin N, Ng HJC, Godula K Journal of the American Chemical Society 40626724 J Am Chem Soc 2025 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/40626724
Glycomaterials for probing host-pathogen interactions and the immune response. Huang ML, Fisher CJ, Godula K Experimental biology and medicine (Maywood, N.J.) 27190259 Exp Biol Med (Maywood) 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27190259
Synthetic glycoscapes: addressing the structural and functional complexity of the glycocalyx. Purcell SC, Godula K Interface focus 30842878 Interface Focus 2019 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/30842878
Embryonic Stem Cell Engineering with a Glycomimetic FGF2/BMP4 Co-Receptor Drives Mesodermal Differentiation in a Three-Dimensional Culture. Naticchia MR, Laubach LK, Tota EM, Lucas TM, Huang ML, Godula K ACS chemical biology 30157624 ACS Chem Biol 2018 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/30157624
Silencing glycosaminoglycan functions in mouse embryonic stem cells with small molecule antagonists. Chatterjee S, Stephenson TN, Michalak AL, Godula K, Huang ML Methods in enzymology 31606078 Methods Enzymol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31606078
Efficient Synthesis of Heparinoid Bioconjugates for Tailoring FGF2 Activity at the Stem Cell-Matrix Interface. Trieger GW, Verespy S 3rd, Gordts PLSM, Godula K Bioconjugate chemistry 30668905 Bioconjug Chem 2019 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/30668905
Glycocalyx Scaffolding to Control Cell Surface Glycan Displays. Huang ML, Tota EM, Verespy S 3rd, Godula K Current protocols in chemical biology 29927116 Curr Protoc Chem Biol 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29927116
Heparin-fibronectin interactions in the development of extracellular matrix insolubility. Raitman I, Huang ML, Williams SA, Friedman B, Godula K, Schwarzbauer JE Matrix biology : journal of the International Society for Matrix Biology 29223498 Matrix Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29223498
Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments. Michalak AL, Trieger GW, Trieger KA, Godula K Advanced healthcare materials 34541824 Adv Healthc Mater 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/34541824
Mucin-mimetic glycan arrays integrating machine learning for analyzing receptor pattern recognition by influenza A viruses. Lucas TM, Gupta C, Altman MO, Sanchez E, Naticchia MR, Gagneux P, Singharoy A, Godula K Chem 34993358 Chem 2021 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/34993358
LDL-Bound PCSK9 Has a Slower Clearance Kinetic and Higher Use for HSPGs Than Free-PCSK9-Brief Report. Pacheco-Velázquez SC, Oleaga C, Ramms B, Hay J, Mueller PA, López-Aguilar E, Miles J, Porell RN, Cheng C, Godula K, Tavori H, Gordts PLSM, Fazio S, Pamir N Arteriosclerosis, thrombosis, and vascular biology 40605748 Arterioscler Thromb Vasc Biol 2025 Sep https://www.ncbi.nlm.nih.gov/pubmed/40605748
Synthetic Mucus Nanobarriers for Identification of Glycan-Dependent Primary Influenza A Infection Inhibitors. Cohen M, Senaati HP, Fisher CJ, Huang ML, Gagneux P, Godula K ACS central science 27800553 ACS Cent Sci 2016 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/27800553
Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Huang ML, Michalak AL, Fisher CJ, Christy M, Smith RAA, Godula K Stem cells (Dayton, Ohio) 28984039 Stem Cells 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28984039
Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries. Honigfort DJ, Zhang MH, Verespy S, Godula K Faraday discussions 31313786 Faraday Discuss 2019 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/31313786
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD Nature chemical biology 33846619 Nat Chem Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33846619
Glycocalyx crowding with mucin mimetics strengthens binding of soluble and virus-associated lectins to host cell glycan receptors. Honigfort DJ, Altman MO, Gagneux P, Godula K Proceedings of the National Academy of Sciences of the United States of America 34583992 Proc Natl Acad Sci U S A 2021 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/34583992
Glycocalyx scaffolding with synthetic nanoscale glycomaterials. Huang ML, Purcell SC, Verespy S III, Wang Y, Godula K Biomaterials science 28616946 Biomater Sci 2017 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/28616946
Influencing Early Stages of Neuromuscular Junction Formation through Glycocalyx Engineering. Huang ML, Tota EM, Lucas TM, Godula K ACS chemical neuroscience 30095249 ACS Chem Neurosci 2018 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/30095249
Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics. Huang ML, Smith RA, Trieger GW, Godula K Methods in molecular biology (Clifton, N.J.) 26537476 Methods Mol Biol 2016 https://www.ncbi.nlm.nih.gov/pubmed/26537476
Spatially controlled glycocalyx engineering for growth factor patterning in embryoid bodies. Naticchia MR, Laubach LK, Honigfort DJ, Purcell SC, Godula K Biomaterials science 33409513 Biomater Sci 2021 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/33409513
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD Cell 32970989 Cell 2020 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/32970989
Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism. Trieger GW, Pessentheiner AR, Purcell SC, Green CR, DeForest N, Willert K, Majithia AR, Metallo CM, Godula K, Gordts PLSM The Journal of biological chemistry 36931394 J Biol Chem 2023 May https://www.ncbi.nlm.nih.gov/pubmed/36931394
A Practical Guide for CRISPR-Cas9-Induced Mutations in Axolotls. Sousounis K, Courtemanche K, Whited JL Methods in molecular biology (Clifton, N.J.) 36272086 Methods Mol Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36272086
Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT Circulation 29348261 Circulation 2018 May 15 https://www.ncbi.nlm.nih.gov/pubmed/29348261
Repeated removal of developing limb buds permanently reduces appendage size in the highly-regenerative axolotl. Bryant DM, Sousounis K, Farkas JE, Bryant S, Thao N, Guzikowski AR, Monaghan JR, Levin M, Whited JL Developmental biology 28235582 Dev Biol 2017 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/28235582
Common themes in tetrapod appendage regeneration: a cellular perspective. Miller BM, Johnson K, Whited JL EvoDevo 31236203 Evodevo 2019 https://www.ncbi.nlm.nih.gov/pubmed/31236203
Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities. Whited JL, Levin M Current opinion in genetics & development 31442749 Curr Opin Genet Dev 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31442749
von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration. Leigh ND, Sessa S, Dragalzew AC, Payzin-Dogru D, Sousa JF, Aggouras AN, Johnson K, Dunlap GS, Haas BJ, Levin M, Schneider I, Whited JL Evolution & development 32163674 Evol Dev 2020 Jul https://www.ncbi.nlm.nih.gov/pubmed/32163674
Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration. Sousounis K, Bryant DM, Martinez Fernandez J, Eddy SS, Tsai SL, Gundberg GC, Han J, Courtemanche K, Levin M, Whited JL eLife 32142407 Elife 2020 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/32142407
Parallels between wound healing, epimorphic regeneration and solid tumors. Wong AY, Whited JL Development (Cambridge, England) 31898582 Development 2020 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/31898582
Discussing limb development and regeneration in Barcelona: The future is at hand. Rosello-Diez A, Whited JL Developmental dynamics : an official publication of the American Association of Anatomists 31587395 Dev Dyn 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31587395
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors. Bryant DM, Johnson K, DiTommaso T, Tickle T, Couger MB, Payzin-Dogru D, Lee TJ, Leigh ND, Kuo TH, Davis FG, Bateman J, Bryant S, Guzikowski AR, Tsai SL, Coyne S, Ye WW, Freeman RM Jr, Peshkin L, Tabin CJ, Regev A, Haas BJ, Whited JL Cell reports 28099853 Cell Rep 2017 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/28099853
Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls. Bryant DM, Sousounis K, Payzin-Dogru D, Bryant S, Sandoval AGW, Martinez Fernandez J, Mariano R, Oshiro R, Wong AY, Leigh ND, Johnson K, Whited JL NPJ Regenerative medicine 29302364 NPJ Regen Med 2017 https://www.ncbi.nlm.nih.gov/pubmed/29302364
Adrenergic signaling coordinates distant and local responses to amputation in axolotl. Payzin-Dogru D, Froitzheim T, Blair SJ, Jena SG, Singer H, Paoli JC, Kim RT, Kriukov E, Wilson SE, Hou R, Savage AM, Cat V, Cammarata LV, Wu SYC, Bothe V, Erdogan B, Hossain S, Lopez N, Losner J, Velazquez Matos J, Min S, Böhm S, Striker AE, Dooling KE, Freedman AH, Groves B, Tajer B, Kalu G, Wynn E, Wong AYL, Fröbisch N, Baranov P, Plikus MV, Buenrostro JD, Haas BJ, Chiu IM, Sackton TB, Whited JL Cell 41138727 Cell 2025 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/41138727
Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution. Leigh ND, Dunlap GS, Johnson K, Mariano R, Oshiro R, Wong AY, Bryant DM, Miller BM, Ratner A, Chen A, Ye WW, Haas BJ, Whited JL Nature communications 30514844 Nat Commun 2018 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/30514844
Adrenergic signaling coordinates distant and local responses to amputation in axolotl. Payzin-Dogru D, Froitzheim T, Blair SJ, Jena SG, Singer H, Paoli JC, Kim RT, Kriukov E, Wilson SE, Hou R, Savage AM, Cat V, Cammarata LV, Wu SYC, Bothe V, Erdogan B, Hossain S, Lopez N, Losner J, Matos JV, Min S, Böhm S, Striker AE, Dooling KE, Freedman AH, Groves B, Tajer B, Kalu G, Wynn E, Wong AYL, Fröbisch N, Baranov P, Plikus MV, Buenrostro JD, Haas BJ, Chiu IM, Sackton TB, Whited JL bioRxiv : the preprint server for biology 40777403 bioRxiv 2025 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/40777403
Systemic cell cycle activation is induced following complex tissue injury in axolotl. Johnson K, Bateman J, DiTommaso T, Wong AY, Whited JL Developmental biology 29111100 Dev Biol 2018 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/29111100
Advances in Decoding Axolotl Limb Regeneration. Haas BJ, Whited JL Trends in genetics : TIG 28648452 Trends Genet 2017 Aug https://www.ncbi.nlm.nih.gov/pubmed/28648452
Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task. Bollu T, Whitehead SC, Prasad N, Walker J, Shyamkumar N, Subramaniam R, Kardon B, Cohen I, Goldberg JH Journal of neurophysiology 39081209 J Neurophysiol 2024 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/39081209
Cortex-dependent corrections as the tongue reaches for and misses targets. Bollu T, Ito BS, Whitehead SC, Kardon B, Redd J, Liu MH, Goldberg JH Nature 34012117 Nature 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34012117
Automated home cage training of mice in a hold-still center-out reach task. Bollu T, Whitehead SC, Prasad N, Walker J, Shyamkumar N, Subramaniam R, Kardon B, Cohen I, Goldberg JH Journal of neurophysiology 30540551 J Neurophysiol 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30540551
2018 PLOS Genetics Research Prize: Bundling, stabilizing, organizing-The orchestration of acentriolar spindle assembly by microtubule motor proteins. Barsh GS, Bhalla N, Cole F, Copenhaver GP, Lacefield S, Libuda DE PLoS genetics 30212501 PLoS Genet 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30212501
RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1. Vélez-Cruz R, Manickavinayaham S, Biswas AK, Clary RW, Premkumar T, Cole F, Johnson DG Genes & development 27940962 Genes Dev 2016 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/27940962
Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Patel L, Kang R, Rosenberg SC, Qiu Y, Raviram R, Chee S, Hu R, Ren B, Cole F, Corbett KD Nature structural & molecular biology 30778236 Nat Struct Mol Biol 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30778236
MutSgamma promotes meiotic recombination and homolog pairing in mouse spermatocytes. Frasca M, Paniker L, Kang R, Chakraborty P, Pandey A, LoPresti J, Cole F Genetics 40404295 Genetics 2025 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/40404295
Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis. Premkumar T, Paniker L, Kang R, Biot M, Humphrey E, Destain H, Ferranti I, Okulate I, Nguyen H, Kilaru V, Frasca M, Chakraborty P, Cole F Molecular cell 37595556 Mol Cell 2023 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/37595556
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S Nature cell biology 27820601 Nat Cell Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27820601
X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome. Zelazowski MJ, Cole F Nature structural & molecular biology 27045445 Nat Struct Mol Biol 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/27045445
Special issue on "recent advances in meiosis from DNA replication to chromosome segregation". Cole F, Borde V Chromosoma 31616989 Chromosoma 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31616989
Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes. Zelazowski MJ, Sandoval M, Paniker L, Hamilton HM, Han J, Gribbell MA, Kang R, Cole F Cell 28942922 Cell 2017 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/28942922
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD PLoS genetics 28570559 PLoS Genet 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28570559
53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF EMBO reports 27670884 EMBO Rep 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27670884
Missing the Mark: PRDM9-Dependent Methylation Is Required for Meiotic DSB Targeting. Kang R, Zelazowski MJ, Cole F Molecular cell 29499130 Mol Cell 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29499130
The Impact of Implementation Fidelity on Mortality Under a CD4-Stratified Timing Strategy for Antiretroviral Therapy in Patients With Tuberculosis. Patel MR, Westreich D, Yotebieng M, Nana M, Eron JJ, Behets F, Van Rie A American journal of epidemiology 25787266 Am J Epidemiol 2015 May 1 https://www.ncbi.nlm.nih.gov/pubmed/25787266
Body mass index, calcium supplementation and risk of colorectal adenomas. Barry EL, Lund JL, Westreich D, Mott LA, Ahnen DJ, Beck GJ, Bostick RM, Bresalier RS, Burke CA, Church TR, Rees JR, Robertson DJ, Baron JA International journal of cancer 30117164 Int J Cancer 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30117164
A review of time scale fundamentals in the g-formula and insidious selection bias. Keil AP, Edwards JK Current epidemiology reports 30555772 Curr Epidemiol Rep 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30555772
Inverse Probability Weights for the Analysis of Polytomous Outcomes. Richardson DB, Kinlaw AC, Keil AP, Naimi AI, Kaufman JS, Cole SR American journal of epidemiology 29390115 Am J Epidemiol 2018 May 1 https://www.ncbi.nlm.nih.gov/pubmed/29390115
The Authors Respond. Lesko CR, Buchanan AL, Westreich D, Edwards JK, Hudgens MG, Cole SR Epidemiology (Cambridge, Mass.) 29023242 Epidemiology 2018 Mar https://www.ncbi.nlm.nih.gov/pubmed/29023242
Exploring the Subtleties of Inverse Probability Weighting and Marginal Structural Models. Breskin A, Cole SR, Westreich D Epidemiology (Cambridge, Mass.) 29384789 Epidemiology 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29384789
Incident obstructive lung disease and mortality among people with HIV and a history of injecting drugs. Kalmin MM, Westreich D, Drummond BM, Sun J, Mehta SH, Kirk GD AIDS (London, England) 33831913 AIDS 2021 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/33831913
Effect of Postnatal HIV Treatment on Clinical Mastitis and Breast Inflammation in HIV-Infected Breast-feeding Women. Zadrozny S, Westreich D, Hudgens MG, Chasela C, Jamieson DJ, Martinson F, Zimba C, Tegha G, Hoffman I, Miller WC, Pence BW, King CC, Kourtis AP, Msungama W, van der Horst C, BAN Study Team Paediatric and perinatal epidemiology 28205255 Paediatr Perinat Epidemiol 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28205255
Invited Commentary: Causal Inference Across Space and Time-Quixotic Quest, Worthy Goal, or Both? Edwards JK, Lesko CR, Keil AP American journal of epidemiology 28679174 Am J Epidemiol 2017 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/28679174
Comparison of Methods to Generalize Randomized Clinical Trial Results Without Individual-Level Data for the Target Population. Hong JL, Webster-Clark M, Jonsson Funk M, Stürmer T, Dempster SE, Cole SR, Herr I, LoCasale R American journal of epidemiology 30312378 Am J Epidemiol 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30312378
UK Biobank, big data, and the consequences of non-representativeness. Keyes KM, Westreich D Lancet (London, England) 30938313 Lancet 2019 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/30938313
Use of Intrauterine Devices and Risk of Human Immunodeficiency Virus Acquisition Among Insured Women in the United States. Marcus JL, Snowden JM, Murray Horwitz ME, Toh S, Horgan C, Tilney RC, Rajbhandari R, Back S, Westreich DJ Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 31412356 Clin Infect Dis 2020 May 6 https://www.ncbi.nlm.nih.gov/pubmed/31412356
Age at Entry Into Care, Timing of Antiretroviral Therapy Initiation, and 10-Year Mortality Among HIV-Seropositive Adults in the United States. Edwards JK, Cole SR, Westreich D, Mugavero MJ, Eron JJ, Moore RD, Mathews WC, Hunt P, Williams C, Centers for AIDS Research Network of Integrated Clinical Systems investigators Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 26082505 Clin Infect Dis 2015 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/26082505
Risk. Cole SR, Hudgens MG, Brookhart MA, Westreich D American journal of epidemiology 25660080 Am J Epidemiol 2015 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/25660080
Generalizing Randomized Clinical Trial Results: Implementation and Challenges Related to Missing Data in the Target Population. Hong JL, Jonsson Funk M, LoCasale R, Dempster SE, Cole SR, Webster-Clark M, Edwards JK, Stürmer T American journal of epidemiology 29020193 Am J Epidemiol 2018 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/29020193
When Is a Complete-Case Approach to Missing Data Valid? The Importance of Effect-Measure Modification. Ross RK, Breskin A, Westreich D American journal of epidemiology 32601706 Am J Epidemiol 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/32601706
Poverty, Deprivation, and Mortality Risk Among Women With HIV in the United States. Edmonds A, Breskin A, Cole SR, Westreich D, Ramirez C, Cocohoba J, Wingood G, Cohen MH, Golub ET, Kassaye SG, Metsch LR, Sharma A, Konkle-Parker D, Wilson TE, Adimora AA Epidemiology (Cambridge, Mass.) 34347686 Epidemiology 2021 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/34347686
RESOLVING AN APPARENT PARADOX IN DOUBLY ROBUST ESTIMATORS. Keil AP, Mooney SJ, Jonsson Funk M, Cole SR, Edwards JK, Westreich D American journal of epidemiology 29394330 Am J Epidemiol 2018 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/29394330
Generalizability of randomized trial results to target populations: Design and analysis possibilities. Stuart EA, Ackerman B, Westreich D Research on social work practice 30034203 Res Soc Work Pract 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/30034203
From Patients to Policy: Population Intervention Effects in Epidemiology. Westreich D Epidemiology (Cambridge, Mass.) 28282339 Epidemiology 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28282339
Marginal Structural Models for Risk or Prevalence Ratios for a Point Exposure Using a Disease Risk Score. Richardson DB, Keil AP, Kinlaw AC, Cole SR American journal of epidemiology 30726868 Am J Epidemiol 2019 May 1 https://www.ncbi.nlm.nih.gov/pubmed/30726868
Baseline Characteristics Explain Differences in Effectiveness of Randomization to Daily Oral TDF/FTC PrEP Between Transgender Women and Cisgender Men Who Have Sex With Men in the iPrEx Trial. Mehrotra ML, Westreich D, McMahan VM, Glymour MM, Geng E, Grant RM, Glidden DV Journal of acquired immune deficiency syndromes (1999) 31192894 J Acquir Immune Defic Syndr 2019 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/31192894
You are smarter than you think: (super) machine learning in context. Keil AP, Edwards JK European journal of epidemiology 29744711 Eur J Epidemiol 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29744711
Toward a Clearer Definition of Selection Bias When Estimating Causal Effects. Lu H, Cole SR, Howe CJ, Westreich D Epidemiology (Cambridge, Mass.) 35700187 Epidemiology 2022 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/35700187
Invited Commentary: Beware the Test-Negative Design. Westreich D, Hudgens MG American journal of epidemiology 27587722 Am J Epidemiol 2016 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/27587722
Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care. Bengtson AM, Pence BW, Gaynes BN, Quinlivan EB, Heine AD, OʼDonnell JK, Crane HM, Mathews WC, Moore RD, Westreich D, OʼCleirigh C, Christopoulos K, Mimiaga MJ, Mugavero MJ Journal of acquired immune deficiency syndromes (1999) 27668804 J Acquir Immune Defic Syndr 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27668804
The Effects of Hepatitis C Infection and Treatment on All-cause Mortality Among People Living With Human Immunodeficiency Virus. Breskin A, Westreich D, Cole SR, Hudgens MG, Hurt CB, Seaberg EC, Thio CL, Tien PC, Adimora AA Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 30321289 Clin Infect Dis 2019 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/30321289
The Effects of Hepatitis C Treatment Eligibility Criteria on All-cause Mortality Among People With Human Immunodeficiency Virus. Breskin A, Westreich D, Hurt CB, Cole SR, Hudgens MG, Seaberg EC, Thio CL, Tien PC, Adimora AA Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 30615096 Clin Infect Dis 2019 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/30615096
The effect of antiretroviral therapy on all-cause mortality, generalized to persons diagnosed with HIV in the USA, 2009-11. Lesko CR, Cole SR, Hall HI, Westreich D, Miller WC, Eron JJ, Li J, Mugavero MJ, CNICS Investigators International journal of epidemiology 26772869 Int J Epidemiol 2016 Feb https://www.ncbi.nlm.nih.gov/pubmed/26772869
An Illustration of Inverse Probability Weighting to Estimate Policy-Relevant Causal Effects. Edwards JK, Cole SR, Lesko CR, Mathews WC, Moore RD, Mugavero MJ, Westreich D American journal of epidemiology 27469514 Am J Epidemiol 2016 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/27469514
An updated systematic review of epidemiological evidence on hormonal contraceptive methods and HIV acquisition in women. Polis CB, Curtis KM, Hannaford PC, Phillips SJ, Chipato T, Kiarie JN, Westreich DJ, Steyn PS AIDS (London, England) 27500670 AIDS 2016 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/27500670
Reduction in diarrhoeal rates through interventions that prevent unnecessary antibiotic exposure early in life in an observational birth cohort. Rogawski ET, Meshnick SR, Becker-Dreps S, Adair LS, Sandler RS, Sarkar R, Kattula D, Ward HD, Kang G, Westreich DJ Journal of epidemiology and community health 26621194 J Epidemiol Community Health 2016 May https://www.ncbi.nlm.nih.gov/pubmed/26621194
Transportability of Trial Results Using Inverse Odds of Sampling Weights. Westreich D, Edwards JK, Lesko CR, Stuart E, Cole SR American journal of epidemiology 28535275 Am J Epidemiol 2017 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/28535275
Quantifying Cancer Risk from Radiation. Keil AP, Richardson DB Risk analysis : an official publication of the Society for Risk Analysis 29211917 Risk Anal 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29211917
The Authors Respond. Breskin A, Cole SR, Hudgens MG Epidemiology (Cambridge, Mass.) 30052540 Epidemiology 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30052540
Generalizing Study Results: A Potential Outcomes Perspective. Lesko CR, Buchanan AL, Westreich D, Edwards JK, Hudgens MG, Cole SR Epidemiology (Cambridge, Mass.) 28346267 Epidemiology 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28346267
Commentary: Epidemiology in the era of big data. Mooney SJ, Westreich DJ, El-Sayed AM Epidemiology (Cambridge, Mass.) 25756221 Epidemiology 2015 May https://www.ncbi.nlm.nih.gov/pubmed/25756221
Invited commentary: every good randomization deserves observation. Westreich D, Edwards JK American journal of epidemiology 26487342 Am J Epidemiol 2015 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/26487342
Transporting Subgroup Analyses of Randomized Controlled Trials for Planning Implementation of New Interventions. Mehrotra ML, Westreich D, Glymour MM, Geng E, Glidden DV American journal of epidemiology 33615327 Am J Epidemiol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/33615327
G-computation for policy-relevant effects of interventions on time-to-event outcomes. Breskin A, Edmonds A, Cole SR, Westreich D, Cocohoba J, Cohen MH, Kassaye SG, Metsch LR, Sharma A, Williams MS, Adimora AA International journal of epidemiology 33141177 Int J Epidemiol 2021 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/33141177
The Intersections of COVID-19, HIV, and Race/Ethnicity: Machine Learning Methods to Identify and Model Risk Factors for Severe COVID-19 in a Large U.S. National Dataset. Kunz M, Rott KW, Hurwitz E, Kunisaki K, Sun J, Wilkins KJ, Islam JY, Patel R, Safo SE, National Covid Cohort Collaborative (N3C) Consortium AIDS and behavior 38326668 AIDS Behav 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38326668
Causal Impact: Epidemiological Approaches for a Public Health of Consequence. Westreich D, Edwards JK, Rogawski ET, Hudgens MG, Stuart EA, Cole SR American journal of public health 27153017 Am J Public Health 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27153017
Smoking, HIV, and risk of pregnancy loss. Westreich D, Cates J, Cohen M, Weber KM, Seidman D, Cropsey K, Wright R, Milam J, Young MA, Mehta CC, Gustafson DR, Golub ET, Fischl MA, Adimora AA AIDS (London, England) 27902507 AIDS 2017 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/27902507
Brief Report: Estimating Differences and Ratios in Median Times to Event. Rogawski ET, Westreich DJ, Kang G, Ward HD, Cole SR Epidemiology (Cambridge, Mass.) 27465526 Epidemiology 2016 Nov https://www.ncbi.nlm.nih.gov/pubmed/27465526
A longitudinal, HIV care continuum: 10-year restricted mean time in each care continuum stage after enrollment in care, by history of IDU. Lesko CR, Edwards JK, Moore RD, Lau B AIDS (London, England) 27314178 AIDS 2016 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/27314178
Estimating the Impact of Changes to Occupational Standards for Silica Exposure on Lung Cancer Mortality. Keil AP, Richardson DB, Westreich D, Steenland K Epidemiology (Cambridge, Mass.) 29870429 Epidemiology 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/29870429
Target Validity and the Hierarchy of Study Designs. Westreich D, Edwards JK, Lesko CR, Cole SR, Stuart EA American journal of epidemiology 30299451 Am J Epidemiol 2019 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/30299451
Primary non-adherence and the new-user design. Li X, Cole SR, Westreich D, Brookhart MA Pharmacoepidemiology and drug safety 29460385 Pharmacoepidemiol Drug Saf 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29460385
The effect of early life antibiotic exposures on diarrheal rates among young children in Vellore, India. Rogawski ET, Westreich D, Becker-Dreps S, Adair LS, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick SR, Kang G The Pediatric infectious disease journal 25742244 Pediatr Infect Dis J 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25742244
Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India. Rogawski ET, Westreich DJ, Adair LS, Becker-Dreps S, Sandler RS, Sarkar R, Kattula D, Ward HD, Meshnick S, Kang G The Journal of pediatrics 26372535 J Pediatr 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26372535
Generalizing the per-protocol treatment effect: The case of ACTG A5095. Lu H, Cole SR, Hall HI, Schisterman EF, Breger TL, K Edwards J, Westreich D Clinical trials (London, England) 30326736 Clin Trials 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30326736
Using Bounds to Compare the Strength of Exchangeability Assumptions for Internal and External Validity. Breskin A, Westreich D, Cole SR, Edwards JK American journal of epidemiology 30834430 Am J Epidemiol 2019 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/30834430
Misclassification in defining and diagnosing microcephaly. Kalmin MM, Gower EW, Stringer EM, Bowman NM, Rogawski McQuade ET, Westreich D Paediatric and perinatal epidemiology 31347726 Paediatr Perinat Epidemiol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31347726
Two-stage g-computation: Evaluating Treatment and Intervention Impacts in Observational Cohorts When Exposure Information Is Partly Missing. Breger TL, Edwards JK, Cole SR, Westreich D, Pence BW, Adimora AA Epidemiology (Cambridge, Mass.) 32657953 Epidemiology 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32657953
Use of electronic health record data and machine learning to identify candidates for HIV pre-exposure prophylaxis: a modelling study. Marcus JL, Hurley LB, Krakower DS, Alexeeff S, Silverberg MJ, Volk JE The lancet. HIV 31285183 Lancet HIV 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31285183
Thirteen Questions About Using Machine Learning in Causal Research (You Won't Believe the Answer to Number 10!). Mooney SJ, Keil AP, Westreich DJ American journal of epidemiology 33751024 Am J Epidemiol 2021 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/33751024
Unraveling the mechanism of cell death induced by chemical fibrils. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA Nature chemical biology 25262416 Nat Chem Biol 2014 Nov https://www.ncbi.nlm.nih.gov/pubmed/25262416
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS Cell 25307932 Cell 2014 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/25307932
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC Nature 32238925 Nature 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32238925
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Liu N, Lee CH, Swigut T, Grow E, Gu B, Bassik MC, Wysocka J Nature 29211708 Nature 2018 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/29211708
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes. Hess GT, Tycko J, Yao D, Bassik MC Molecular cell 28985508 Mol Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28985508
SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Wang Z, Hausmann S, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK Cancer cell 32442403 Cancer Cell 2020 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/32442403
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis. Kamber RA, Nishiga Y, Morton B, Banuelos AM, Barkal AA, Vences-Catalán F, Gu M, Fernandez D, Seoane JA, Yao D, Liu K, Lin S, Spees K, Curtis C, Jerby-Arnon L, Weissman IL, Sage J, Bassik MC Nature 34497417 Nature 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34497417
CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity. Tsui CK, Barfield RM, Fischer CR, Morgens DW, Li A, Smith BAH, Gray MA, Bertozzi CR, Rabuka D, Bassik MC Nature chemical biology 31451760 Nat Chem Biol 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31451760
Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA Nucleic acids research 25270879 Nucleic Acids Res 2014 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/25270879
Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway. Dubreuil MM, Morgens DW, Okumoto K, Honsho M, Contrepois K, Lee-McMullen B, Traber GM, Sood RS, Dixon SJ, Snyder MP, Fujiki Y, Bassik MC Cell reports 32023459 Cell Rep 2020 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/32023459
Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC eLife 31674906 Elife 2019 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/31674906
A genome-wide atlas of co-essential modules assigns function to uncharacterized genes. Wainberg M, Kamber RA, Balsubramani A, Meyers RM, Sinnott-Armstrong N, Hornburg D, Jiang L, Chan J, Jian R, Gu M, Shcherbina A, Dubreuil MM, Spees K, Meuleman W, Snyder MP, Bassik MC, Kundaje A Nature genetics 33859415 Nat Genet 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33859415
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Marschallinger J, Iram T, Zardeneta M, Lee SE, Lehallier B, Haney MS, Pluvinage JV, Mathur V, Hahn O, Morgens DW, Kim J, Tevini J, Felder TK, Wolinski H, Bertozzi CR, Bassik MC, Aigner L, Wyss-Coray T Nature neuroscience 31959936 Nat Neurosci 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31959936
SLC19A1 Is an Importer of the Immunotransmitter cGAMP. Ritchie C, Cordova AF, Hess GT, Bassik MC, Li L Molecular cell 31126740 Mol Cell 2019 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/31126740
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD Nature genetics 29507424 Nat Genet 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29507424
Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs. Lu A, Wawro P, Morgens DW, Portela F, Bassik MC, Pfeffer SR eLife 30556811 Elife 2018 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/30556811
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O Cell 30612740 Cell 2019 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/30612740
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Han K, Jeng EE, Hess GT, Morgens DW, Li A, Bassik MC Nature biotechnology 28319085 Nat Biotechnol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28319085
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen. Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC Cell host & microbe 31540829 Cell Host Microbe 2019 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/31540829
KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics. Milic B, Chakraborty A, Han K, Bassik MC, Block SM Proceedings of the National Academy of Sciences of the United States of America 29703754 Proc Natl Acad Sci U S A 2018 May 15 https://www.ncbi.nlm.nih.gov/pubmed/29703754
Translation readthrough mitigation. Arribere JA, Cenik ES, Jain N, Hess GT, Lee CH, Bassik MC, Fire AZ Nature 27281202 Nature 2016 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/27281202
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia. Duque-Afonso J, Lin CH, Han K, Wei MC, Feng J, Kurzer JH, Schneidawind C, Wong SH, Bassik MC, Cleary ML Cancer research 27758892 Cancer Res 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27758892
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages. Cohen A, Jeng EE, Voorhies M, Symington J, Ali N, Rodriguez RA, Bassik MC, Sil A PLoS pathogens 36174103 PLoS Pathog 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/36174103
Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus. Leonardi W, Zilbermintz L, Cheng LW, Zozaya J, Tran SH, Elliott JH, Polukhina K, Manasherob R, Li A, Chi X, Gharaibeh D, Kenny T, Zamani R, Soloveva V, Haddow AD, Nasar F, Bavari S, Bassik MC, Cohen SN, Levitin A, Martchenko M Scientific reports 27686742 Sci Rep 2016 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/27686742
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Hess GT, Frésard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, Bassik MC Nature methods 27798611 Nat Methods 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27798611
Next-generation libraries for robust RNA interference-based genome-wide screens. Kampmann M, Horlbeck MA, Chen Y, Tsai JC, Bassik MC, Gilbert LA, Villalta JE, Kwon SC, Chang H, Kim VN, Weissman JS Proceedings of the National Academy of Sciences of the United States of America 26080438 Proc Natl Acad Sci U S A 2015 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/26080438
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L Molecular cell 33171122 Mol Cell 2020 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/33171122
An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. Coukos R, Yao D, Sanchez MI, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY eLife 34414886 Elife 2021 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/34414886
Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy. Okesli A, Khosla C, Bassik MC Current opinion in biotechnology 28458037 Curr Opin Biotechnol 2017 Dec https://www.ncbi.nlm.nih.gov/pubmed/28458037
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens. Morgens DW, Wainberg M, Boyle EA, Ursu O, Araya CL, Tsui CK, Haney MS, Hess GT, Han K, Jeng EE, Li A, Snyder MP, Greenleaf WJ, Kundaje A, Bassik MC Nature communications 28474669 Nat Commun 2017 May 5 https://www.ncbi.nlm.nih.gov/pubmed/28474669
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC Nature chemical biology 27018887 Nat Chem Biol 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27018887
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes. Morgens DW, Deans RM, Li A, Bassik MC Nature biotechnology 27159373 Nat Biotechnol 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27159373
A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. Gupta A, Ökesli-Armlovich A, Morgens D, Bassik MC, Khosla C The Journal of biological chemistry 31915244 J Biol Chem 2020 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/31915244
A semi-supervised approach to extract pharmacogenomics-specific drug-gene pairs from biomedical literature for personalized medicine. Xu R, Wang Q Journal of biomedical informatics 23570835 J Biomed Inform 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23570835
Large-scale automatic extraction of side effects associated with targeted anticancer drugs from full-text oncological articles. Xu R, Wang Q Journal of biomedical informatics 25817969 J Biomed Inform 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/25817969
A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat. Xu R, Wang Q, Li L BMC genomics 26100814 BMC Genomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26100814
tcTKB: an integrated cardiovascular toxicity knowledge base for targeted cancer drugs. Xu R, Wang Q AMIA ... Annual Symposium proceedings. AMIA Symposium 26958275 AMIA Annu Symp Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26958275
MetabolitePredict: A de novo human metabolomics prediction system and its applications in rheumatoid arthritis. Wang Q, Xu R Journal of biomedical informatics 28600026 J Biomed Inform 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28600026
Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment. Nagaraj AB, Wang QQ, Joseph P, Zheng C, Chen Y, Kovalenko O, Singh S, Armstrong A, Resnick K, Zanotti K, Waggoner S, Xu R, DiFeo A Oncogene 28967908 Oncogene 2018 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/28967908
Drug repositioning for prostate cancer: using a data-driven approach to gain new insights. Wang Q, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 29854243 AMIA Annu Symp Proc 2017 https://www.ncbi.nlm.nih.gov/pubmed/29854243
Combining mechanism-based prediction with patient-based profiling for psoriasis metabolomics biomarker discovery. Wang Q, McCormick TS, Ward NL, Cooper KD, Conic R, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 29854244 AMIA Annu Symp Proc 2017 https://www.ncbi.nlm.nih.gov/pubmed/29854244
Molecular subtyping of Alzheimer's disease with consensus non-negative matrix factorization. Zheng C, Xu R PloS one 34014928 PLoS One 2021 https://www.ncbi.nlm.nih.gov/pubmed/34014928
DenseCNN: A Densely Connected CNN Model for Alzheimer's Disease Classification Based on Hippocampus MRI Data. Wang Q, Li Y, Zheng C, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 33936504 AMIA Annu Symp Proc 2020 https://www.ncbi.nlm.nih.gov/pubmed/33936504
Predict Alzheimer's disease using hippocampus MRI data: a lightweight 3D deep convolutional network model with visual and global shape representations. Katabathula S, Wang Q, Xu R Alzheimer's research & therapy 34030743 Alzheimers Res Ther 2021 May 24 https://www.ncbi.nlm.nih.gov/pubmed/34030743
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X Science advances 33277246 Sci Adv 2020 Dec https://www.ncbi.nlm.nih.gov/pubmed/33277246
Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses. Zhou M, Wang Q, Zheng C, John Rush A, Volkow ND, Xu R Molecular psychiatry 33432189 Mol Psychiatry 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33432189
COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US. Wang Q, Davis PB, Gurney ME, Xu R Alzheimer's & dementia : the journal of the Alzheimer's Association 33559975 Alzheimers Dement 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33559975
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models. Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X Nature communications 35236834 Nat Commun 2022 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/35236834
Context-sensitive network-based disease genetics prediction and its implications in drug discovery. Chen Y, Xu R Bioinformatics (Oxford, England) 28062449 Bioinformatics 2017 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/28062449
A Drug-Side Effect Context-Sensitive Network approach for drug target prediction. Zhou M, Chen Y, Xu R Bioinformatics (Oxford, England) 30428013 Bioinformatics 2019 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/30428013
Disease comorbidity-guided drug repositioning: a case study in schizophrenia. Wang Q, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 30815174 AMIA Annu Symp Proc 2018 https://www.ncbi.nlm.nih.gov/pubmed/30815174
The Alzheimer's comorbidity phenome: mining from a large patient database and phenome-driven genetics prediction. Zheng C, Xu R JAMIA open 30944912 JAMIA Open 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30944912
Association of Epigenetic Clock with Consensus Molecular Subtypes and Overall Survival of Colorectal Cancer. Zheng C, Li L, Xu R Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31375479 Cancer Epidemiol Biomarkers Prev 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31375479
Association of semaglutide with risk of suicidal ideation in a real-world cohort. Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R Nature medicine 38182782 Nat Med 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38182782
Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS). Xu R, Wang Q Journal of biomedical informatics 24177320 J Biomed Inform 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24177320
Combining automatic table classification and relationship extraction in extracting anticancer drug-side effect pairs from full-text articles. Xu R, Wang Q Journal of biomedical informatics 25445920 J Biomed Inform 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25445920
Comparative analysis of a novel disease phenotype network based on clinical manifestations. Chen Y, Zhang X, Zhang GQ, Xu R Journal of biomedical informatics 25277758 J Biomed Inform 2015 Feb https://www.ncbi.nlm.nih.gov/pubmed/25277758
Combining phenome-driven drug-target interaction prediction with patients' electronic health records-based clinical corroboration toward drug discovery. Zhou M, Zheng C, Xu R Bioinformatics (Oxford, England) 32657406 Bioinformatics 2020 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/32657406
Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer's disease in patients with rheumatoid arthritis and psoriasis. Zhou M, Xu R, Kaelber DC, Gurney ME PloS one 32203525 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/32203525
COVID-19 risk, disparities and outcomes in patients with chronic liver disease in the United States. Wang Q, Davis PB, Xu R EClinicalMedicine 33521611 EClinicalMedicine 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33521611
Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume. Conic RR, Damiani G, Schrom KP, Ramser AE, Zheng C, Xu R, McCormick TS, Cooper KD Journal of clinical medicine 31936662 J Clin Med 2020 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/31936662
Epigenetic age acceleration and clinical outcomes in gliomas. Zheng C, Berger NA, Li L, Xu R PloS one 32692766 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/32692766
An iterative approach to detect pleiotropy and perform Mendelian Randomization analysis using GWAS summary statistics. Zhu X, Li X, Xu R, Wang T Bioinformatics (Oxford, England) 33226062 Bioinformatics 2021 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/33226062
Correction: COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States. Wang QQ, Kaelber DC, Xu R, Volkow ND Molecular psychiatry 32999436 Mol Psychiatry 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32999436
Context-sensitive network analysis identifies food metabolites associated with Alzheimer's disease: an exploratory study. Chen Y, Xu R BMC medical genomics 30704467 BMC Med Genomics 2019 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/30704467
Immunotherapy-related adverse events (irAEs): extraction from FDA drug labels and comparative analysis. Wang Q, Xu R JAMIA open 30976759 JAMIA Open 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30976759
Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer. Belur Nagaraj A, Joseph P, Kovalenko O, Wang Q, Xu R, DiFeo A Gynecologic oncology 30301560 Gynecol Oncol 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30301560
Towards precision medicine-based therapies for glioblastoma: interrogating human disease genomics and mouse phenotypes. Chen Y, Gao Z, Wang B, Xu R BMC genomics 27557118 BMC Genomics 2016 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/27557118
Predict drug permeability to blood-brain-barrier from clinical phenotypes: drug side effects and drug indications. Gao Z, Chen Y, Cai X, Xu R Bioinformatics (Oxford, England) 27993785 Bioinformatics 2017 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/27993785
Drug repurposing for glioblastoma based on molecular subtypes. Chen Y, Xu R Journal of biomedical informatics 27697594 J Biomed Inform 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27697594
Comorbidity-driven multi-modal subtype analysis in mild cognitive impairment of Alzheimer's disease. Katabathula S, Davis PB, Xu R Alzheimer's & dementia : the journal of the Alzheimer's Association 36166485 Alzheimers Dement 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36166485
Sex-Specific Heterogeneity of Mild Cognitive Impairment Identified Based on Multi-Modal Data Analysis. Katabathula S, Davis PB, Xu R, Alzheimer’s Disease Neuroimaging Initiative Journal of Alzheimer's disease : JAD 36404544 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/36404544
Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study. Ding P, Xu R Journal of the neurological sciences 37925898 J Neurol Sci 2023 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/37925898
Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population. Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R Nature communications 38806481 Nat Commun 2024 May 28 https://www.ncbi.nlm.nih.gov/pubmed/38806481
Association of GLP-1 Receptor Agonists and Hepatocellular Carcinoma Incidence and Hepatic Decompensation in Patients With Type 2 Diabetes. Wang L, Berger NA, Kaelber DC, Xu R Gastroenterology 38692395 Gastroenterology 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38692395
GLP-1R agonist medications for addiction treatment. Volkow ND, Xu R Addiction (Abingdon, England) 39049203 Addiction 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39049203
An iterative searching and ranking algorithm for prioritising pharmacogenomics genes. Xu R, Wang Q International journal of computational biology and drug design 23428471 Int J Comput Biol Drug Des 2013 https://www.ncbi.nlm.nih.gov/pubmed/23428471
Explore Small Molecule-induced Genome-wide Transcriptional Profiles for Novel Inflammatory Bowel Disease Drug. Cai X, Chen Y, Gao Z, Xu R AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 27570643 AMIA Jt Summits Transl Sci Proc 2016 https://www.ncbi.nlm.nih.gov/pubmed/27570643
Disease Comorbidity Network Guides the Detection of Molecular Evidence for the Link Between Colorectal Cancer and Obesity. Chen Y, Li L, Xu R AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 26306270 AMIA Jt Summits Transl Sci Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26306270
Phenome-based gene discovery provides information about Parkinson's disease drug targets. Chen Y, Xu R BMC genomics 27586503 BMC Genomics 2016 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/27586503
Large-scale mining disease comorbidity relationships from post-market drug adverse events surveillance data. Zheng C, Xu R BMC bioinformatics 30591027 BMC Bioinformatics 2018 Dec 28 https://www.ncbi.nlm.nih.gov/pubmed/30591027
Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson's disease. Chen Y, Cai X, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 26958284 AMIA Annu Symp Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26958284
DenguePredict: An Integrated Drug Repositioning Approach towards Drug Discovery for Dengue. Wang Q, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 26958268 AMIA Annu Symp Proc 2015 https://www.ncbi.nlm.nih.gov/pubmed/26958268
Analysis of disease organ as a novel phenotype towards disease genetics understanding. Luo L, Zheng C, Wang J, Tan M, Li Y, Xu R Journal of biomedical informatics 31207382 J Biomed Inform 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31207382
Towards understanding brain-gut-microbiome connections in Alzheimer's disease. Xu R, Wang Q BMC systems biology 27585440 BMC Syst Biol 2016 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/27585440
Network-based gene prediction for Plasmodium falciparum malaria towards genetics-based drug discovery. Chen Y, Xu R BMC genomics 26099491 BMC Genomics 2015 https://www.ncbi.nlm.nih.gov/pubmed/26099491
Predicting cancer origins with a DNA methylation-based deep neural network model. Zheng C, Xu R PloS one 32384093 PLoS One 2020 https://www.ncbi.nlm.nih.gov/pubmed/32384093
CoMNRank: An integrated approach to extract and prioritize human microbial metabolites from MEDLINE records. Wang Q, Xu R Journal of biomedical informatics 32791237 J Biomed Inform 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32791237
Association of COVID-19 with Risk and Progression of Alzheimer's Disease: Non-Overlapping Two-Sample Mendelian Randomization Analysis of 2.6 Million Subjects. Ding P, Gurney M, Perry G, Xu R Journal of Alzheimer's disease : JAD 38007657 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/38007657
Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization. Wang Q, Davis PB, Qi X, Chen SG, Gurney ME, Perry G, Doraiswamy PM, Xu R Alzheimer's research & therapy 34670619 Alzheimers Res Ther 2021 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/34670619
Association of Aspirin Use with Reduced Risk of Developing Alzheimer's Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study. Gorenflo MP, Davis PB, Kendall EK, Olaker VR, Kaelber DC, Xu R Journal of Alzheimer's disease : JAD 36502331 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/36502331
Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes. Wang L, Xu R, Kaelber DC, Berger NA JAMA network open 38967919 JAMA Netw Open 2024 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/38967919
Interrogating Patient-level Genomics and Mouse Phenomics towards Understanding Cytokines in Colorectal Cancer Metastasis. Cai X, Chen Y, Zheng C, Xu R AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 28815134 AMIA Jt Summits Transl Sci Proc 2017 https://www.ncbi.nlm.nih.gov/pubmed/28815134
A genomics-based systems approach towards drug repositioning for rheumatoid arthritis. Xu R, Wang Q BMC genomics 27557330 BMC Genomics 2016 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/27557330
A systems biology approach to predict and characterize human gut microbial metabolites in colorectal cancer. Wang Q, Li L, Xu R Scientific reports 29670137 Sci Rep 2018 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/29670137
PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery. Xu R, Wang Q Journal of biomedical informatics 26151312 J Biomed Inform 2015 Aug https://www.ncbi.nlm.nih.gov/pubmed/26151312
Phenome-driven disease genetics prediction toward drug discovery. Chen Y, Li L, Zhang GQ, Xu R Bioinformatics (Oxford, England) 26072493 Bioinformatics 2015 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/26072493
Automatic construction of a large-scale and accurate drug-side-effect association knowledge base from biomedical literature. Xu R, Wang Q Journal of biomedical informatics 24928448 J Biomed Inform 2014 Oct https://www.ncbi.nlm.nih.gov/pubmed/24928448
Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis. Wang Q, Xu R BMC genomics 30744546 BMC Genomics 2019 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/30744546
A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X Acta neuropathologica 36104602 Acta Neuropathol 2022 Nov https://www.ncbi.nlm.nih.gov/pubmed/36104602
Automatic extraction, prioritization and analysis of gut microbial metabolites from biomedical literature. Wang Q, Xu R Scientific reports 32561832 Sci Rep 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32561832
When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities. Wang Q, Berger NA, Xu R Blood reviews 33187811 Blood Rev 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33187811
COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States. Wang QQ, Kaelber DC, Xu R, Volkow ND Molecular psychiatry 32929211 Mol Psychiatry 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/32929211
Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans. Zheng C, Fillmore NR, Ramos-Cejudo J, Brophy M, Osorio R, Gurney ME, Qiu WQ, Au R, Perry G, Dubreuil M, Chen SG, Qi X, Davis PB, Do N, Xu R Alzheimer's & dementia : the journal of the Alzheimer's Association 34569707 Alzheimers Dement 2022 Jun https://www.ncbi.nlm.nih.gov/pubmed/34569707
Glucagon-like peptide-1 receptor agonists and pancreatic cancer risk: target trial emulation using real-world data. Wang L, Wang Q, Li L, Kaelber DC, Xu R Journal of the National Cancer Institute 39418202 J Natl Cancer Inst 2025 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/39418202
A knowledge graph-based disease-gene prediction system using multi-relational graph convolution networks. Gao Z, Pan Y, Ding P, Xu R AMIA ... Annual Symposium proceedings. AMIA Symposium 37128437 AMIA Annu Symp Proc 2022 https://www.ncbi.nlm.nih.gov/pubmed/37128437
Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study. Ding P, Gorenflo MP, Zhu X, Xu R Journal of Alzheimer's disease : JAD 36846997 J Alzheimers Dis 2023 https://www.ncbi.nlm.nih.gov/pubmed/36846997
Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease. Tun X, Wang EJ, Gao Z, Lundberg K, Xu R, Hu D International journal of molecular sciences 36982771 Int J Mol Sci 2023 Mar 16 https://www.ncbi.nlm.nih.gov/pubmed/36982771
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Leveraging the Dynamic Blood-Brain Barrier for Central Nervous System Nanoparticle-based Drug Delivery Applications. Copeland C, Stabenfeldt SE Current opinion in biomedical engineering 32432210 Curr Opin Biomed Eng 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32432210
Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain. Hickey KN, Grassi SM, Caplan MR, Stabenfeldt SE Cellular and molecular bioengineering 33643467 Cell Mol Bioeng 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33643467
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Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen. Brown AC, Lavik E, Stabenfeldt SE Bioconjugate chemistry 31246419 Bioconjug Chem 2019 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/31246419
Endogenous repair signaling after brain injury and complementary bioengineering approaches to enhance neural regeneration. Addington CP, Roussas A, Dutta D, Stabenfeldt SE Biomarker insights 25983552 Biomark Insights 2015 https://www.ncbi.nlm.nih.gov/pubmed/25983552
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In Vivo Phage Display as a Biomarker Discovery Tool for the Complex Neural Injury Microenvironment. Martinez BI, Stabenfeldt SE Current protocols 33625787 Curr Protoc 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33625787
Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine. Jensen G, Holloway JL, Stabenfeldt SE Cells 32957463 Cells 2020 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/32957463
Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1α. Addington CP, Dharmawaj S, Heffernan JM, Sirianni RW, Stabenfeldt SE Matrix biology : journal of the International Society for Matrix Biology 27645115 Matrix Biol 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/27645115
Using biomaterials to modulate chemotactic signaling for central nervous system repair. Hickey K, Stabenfeldt SE Biomedical materials (Bristol, England) 29411713 Biomed Mater 2018 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/29411713
Uncovering temporospatial sensitive TBI targeting strategies via in vivo phage display. Martinez BI, Mousa GA, Fleck K, MacCulloch T, Diehnelt CW, Stephanopoulos N, Stabenfeldt SE Science advances 35867794 Sci Adv 2022 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/35867794
Nanoparticle-Based Therapeutics for Brain Injury. Bharadwaj VN, Nguyen DT, Kodibagkar VD, Stabenfeldt SE Advanced healthcare materials 29034608 Adv Healthc Mater 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/29034608
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pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma. Householder KT, DiPerna DM, Chung EP, Luning AR, Nguyen DT, Stabenfeldt SE, Mehta S, Sirianni RW Colloids and surfaces. B, Biointerfaces 29533842 Colloids Surf B Biointerfaces 2018 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/29533842
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Interpreting Reverse Transcriptase Termination and Mutation Events for Greater Insight into the Chemical Probing of RNA. Sexton AN, Wang PY, Rutenberg-Schoenberg M, Simon MD Biochemistry 28820243 Biochemistry 2017 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/28820243
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Enriching s(4) U-RNA Using Methane Thiosulfonate (MTS) Chemistry. Duffy EE, Simon MD Current protocols in chemical biology 27925666 Curr Protoc Chem Biol 2016 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/27925666
Catching RNAs on chromatin using hybridization capture methods. Machyna M, Simon MD Briefings in functional genomics 29126220 Brief Funct Genomics 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29126220
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A Micropatterning Assay for Measuring Cell Chirality. Zhang H, Ronaldson-Bouchard K, Vunjak-Novakovic G, Wan LQ Journal of visualized experiments : JoVE 35343954 J Vis Exp 2022 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/35343954
Effects of Alzheimer's Disease-Related Proteins on the Chirality of Brain Endothelial Cells. Zhang H, Fan J, Zhao Z, Wang C, Wan LQ Cellular and molecular bioengineering 34109002 Cell Mol Bioeng 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34109002
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Cell Chirality as a Novel Measure for Cytotoxicity. Zhang H, Wan LQ Advanced biology 34796704 Adv Biol (Weinh) 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34796704
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Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution. Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ Cell systems 35863345 Cell Syst 2022 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/35863345
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Unified Phase Variables of Relative Degree Two for Human Locomotion. Villarreal DJ, Gregg RD Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 28261013 Annu Int Conf IEEE Eng Med Biol Soc 2016 Aug https://www.ncbi.nlm.nih.gov/pubmed/28261013
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Recent progress and future challenges in structure-based protein-protein interaction prediction. Yuan R, Zhang J, Zhou J, Cong Q Molecular therapy : the journal of the American Society of Gene Therapy 40195117 Mol Ther 2025 May 7 https://www.ncbi.nlm.nih.gov/pubmed/40195117
Sequence-based modeling of three-dimensional genome architecture from kilobase to chromosome scale. Zhou J Nature genetics 35551308 Nat Genet 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35551308
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Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance. Coscia SM, Moore AS, Wong YC, Holzbaur ELF Current opinion in cell biology 38692079 Curr Opin Cell Biol 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38692079
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Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy. Wang W, Wu S, Cen Z, Zhang Y, Chen Y, Huang Y, Cillo AR, Prokopec JS, Quarato G, Vignali DAA, Stewart-Ornstein J, Li S, Lu B, Gong YN Cell reports 36323258 Cell Rep 2022 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/36323258
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Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression. Sugitani N, Vendetti FP, Cipriano AJ, Pandya P, Deppas JJ, Moiseeva TN, Schamus-Haynes S, Wang Y, Palmer D, Osmanbeyoglu HU, Bostwick A, Snyder NW, Gong YN, Aird KM, Delgoffe GM, Beumer JH, Bakkenist CJ Cell reports 36130512 Cell Rep 2022 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/36130512
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Mycobacterium tuberculosis, Mycobacterium kansasii and Rhodococcus equi induce macrophage necroptosis in the presence of a caspase inhibitor acting on a non-canonical target(s). Hu R, Li P, Han J, Huang J, Huang G, Jiang X, Pfau D, Li G, Gong YN, Nathan CF, Zhang L bioRxiv : the preprint server for biology 40950000 bioRxiv 2025 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/40950000
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity. Pandey SP, Yang D, Hedden L, Laughlin CR, Wang W, Soto AS, Winner H, Medina Sanchez L, Campana EE, Engl C, Zeng Y, Rana M, Van Der Kraak L, Bender MJ, Prokopec J, Ferrick JM, Meng X, Fong E, Sun M, Mullett SJ, MacDonald M, Gelhaus SL, Watkins SC, Meisel M, von Moltke J, Xu S, Gong YN, Hinterleitner R Immunity 40701157 Immunity 2025 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/40701157
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D-MAINS: A Deep-Learning Model for the Label-Free Detection of Mitosis, Apoptosis, Interphase, Necrosis, and Senescence in Cancer Cells. He S, Sillah M, Cole AR, Uboveja A, Aird KM, Chen YC, Gong YN Cells 38920634 Cells 2024 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/38920634
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Structural Basis for Allostery in PLP-dependent Enzymes. Tran JU, Brown BL Frontiers in molecular biosciences 35547395 Front Mol Biosci 2022 https://www.ncbi.nlm.nih.gov/pubmed/35547395
Structural basis for dysregulation of aminolevulinic acid synthase in human disease. Taylor JL, Brown BL The Journal of biological chemistry 35093382 J Biol Chem 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35093382
The yeast ALA synthase C-terminus positively controls enzyme structure and function. Tran JU, Brown BL Protein science : a publication of the Protein Society 36807942 Protein Sci 2023 Apr https://www.ncbi.nlm.nih.gov/pubmed/36807942
Elucidating the Role of Human ALAS2 C-terminal Mutations Resulting in Loss of Function and Disease. Taylor JL, Ayres-Galhardo PH, Brown BL Biochemistry 38888931 Biochemistry 2024 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/38888931
A reversible feedback mechanism regulating mitochondrial heme synthesis. Chitrakar I, Roberson AB, Ayres-Galhardo PH, Brown BL bioRxiv : the preprint server for biology 40964252 bioRxiv 2025 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/40964252
Assembly of RNA polymerase II transcription initiation complexes. Farnung L, Vos SM Current opinion in structural biology 35183822 Curr Opin Struct Biol 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35183822
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Structural basis of nucleosome retention during transcription elongation. Filipovski M, Soffers JHM, Vos SM, Farnung L Science (New York, N.Y.) 35709268 Science 2022 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/35709268
Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry. Welp LM, Wulf A, Chernev A, Horokhovskyi Y, Moshkovskii S, Dybkov O, Neumann P, Pašen M, Siraj A, Raabe M, Göthert H, Walshe JL, Infante DA, de A P Schwarzer AC, Dickmanns A, Johannsson S, Schmitzová J, Wohlgemuth I, Netz E, He Y, Fritzemeier K, Delanghe B, Viner R, Vos SM, Oberbeckmann E, Bohnsack KE, Bohnsack MT, Cramer P, Ficner R, Kohlbacher O, Liepe J, Sachsenberg T, Urlaub H Nucleic acids research 40823814 Nucleic Acids Res 2025 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/40823814
A sequence‑encoded promoter proximal super pause stabilizes an offline RNA polymerase II state. Vazquez Nunez RJ, Kesha S, Vos SM bioRxiv : the preprint server for biology 41756838 bioRxiv 2026 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/41756838
Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Su BG, Vos SM Molecular cell 38401543 Mol Cell 2024 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/38401543
The structural basis for RNA slicing by human Argonaute2. Mohamed AA, Wang PY, Bartel DP, Vos SM bioRxiv : the preprint server for biology 39229170 bioRxiv 2024 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/39229170
Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Markert JW, Vos SM, Farnung L Nature communications 38065958 Nat Commun 2023 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/38065958
Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing. Fendler NL, Ly J, Welp L, Urlaub H, Vos SM bioRxiv : the preprint server for biology 38895295 bioRxiv 2024 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/38895295
The structural basis for RNA slicing by human Argonaute2. Mohamed AA, Wang PY, Bartel DP, Vos SM Cell reports 39932188 Cell Rep 2025 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/39932188
ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss. Wang J, Fendler NL, Shukla A, Wu SY, Challa A, Lee J, Joachimiak LA, Minna JD, Chiang CM, Vos SM, D'Orso I Molecular cell 39532099 Mol Cell 2024 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/39532099
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Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae. Guo W, Zhang S, Park JH, Stanton V, Asp M, Herrera H, Tai JB, Yue J, Wang J, Guo J, Kumar R, Botting JM, Wu S, Yan J, Klose KE, Yildiz FH, Liu J Nature microbiology 41174224 Nat Microbiol 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41174224
Morphogenesis of confined biofilms: how mechanical interactions determine cellular patterning and global geometry. Nam KM, Yan J Soft matter 39901805 Soft Matter 2025 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/39901805
Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species. Reichhardt C, Matwichuk ML, Lewerke LT, Jacobs HM, Yan J, Parsek MR mBio 39982068 mBio 2025 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/39982068
Lipoarabinomannan mediates localized cell wall integrity during division in mycobacteria. Sparks IL, Kado T, Prithviraj M, Nijjer J, Yan J, Morita YS Nature communications 38467648 Nat Commun 2024 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/38467648
Dissecting the physics of bacterial biofilms with agent-based simulations. Nam KM, Li C, Cockx BJR, Nguyen DT, Li Y, Kreft JU, Yan J Current opinion in solid state & materials science 40538632 Curr Opin Solid State Mater Sci 2025 Jul https://www.ncbi.nlm.nih.gov/pubmed/40538632
Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement. Barrasso K, Chac D, Debela MD, Geigel C, Steenhaut A, Rivera Seda A, Dunmire CN, Harris JB, Larocque RC, Midani FS, Qadri F, Yan J, Weil AA, Ng WL eLife 35343438 Elife 2022 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/35343438
Social evolution of shared biofilm matrix components. Tai JB, Mukherjee S, Nero T, Olson R, Tithof J, Nadell CD, Yan J Proceedings of the National Academy of Sciences of the United States of America 35771939 Proc Natl Acad Sci U S A 2022 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/35771939
Vibrio cholerae RbmB is an α-1,4-polysaccharide lyase with biofilm-disrupting activity against Vibrio polysaccharide (VPS). Weerasekera R, Moreau A, Huang X, Nam KM, Hinbest AJ, Huynh Y, Liu X, Ashwood C, Pepi LE, Paulson E, Cegelski L, Yan J, Olson R PLoS pathogens 39621768 PLoS Pathog 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39621768
Vibrio cholerae adhesin-derived peptide mediates strong pull-off forces in aqueous high-ionic-strength environments. Ahmed ST, Zhai S, Huang X, Sulaja S, Adewole A, Ioffe A, Merg AD, Yan J, Eguiluz RCA bioRxiv : the preprint server for biology 40909722 bioRxiv 2025 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/40909722
Mechanical forces drive a reorientation cascade leading to biofilm self-patterning. Nijjer J, Li C, Zhang Q, Lu H, Zhang S, Yan J Nature communications 34789754 Nat Commun 2021 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/34789754
Biofilms as self-shaping growing nematics. Nijjer J, Li C, Kothari M, Henzel T, Zhang Q, Tai JB, Zhou S, Cohen T, Zhang S, Yan J Nature physics 39055904 Nat Phys 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/39055904
Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization. Huang X, Nero T, Weerasekera R, Matej KH, Hinbest A, Jiang Z, Lee RF, Wu L, Chak C, Nijjer J, Gibaldi I, Yang H, Gamble N, Ng WL, Malaker SA, Sumigray K, Olson R, Yan J Nature communications 37055389 Nat Commun 2023 Apr 13 https://www.ncbi.nlm.nih.gov/pubmed/37055389
New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology. Tai JB, Ferrell MJ, Yan J, Waters CM Advances in experimental medicine and biology 36792869 Adv Exp Med Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/36792869
Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms. Li C, Nijjer J, Feng L, Zhang Q, Yan J, Zhang S Soft matter 38563244 Soft Matter 2024 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/38563244
Crystal structure of Vibrio cholerae polysaccharide lyase RbmB bound to Vibrio polysaccharide (VPS) fragments provides insights into substrate recognition and cleavage. Weerasekera R, Moreau A, Huang X, Potapova A, Schwechheimer C, Kandel R, Huynh Y, Cannizzo O, Gordon R, Gerace E, Hinbest AJ, Yang Y, Jiang X, Woods RJ, Yan J, Yildiz FH, Olson R Proceedings of the National Academy of Sciences of the United States of America 41805565 Proc Natl Acad Sci U S A 2026 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/41805565
A genome-wide atlas of human cell morphology. Ramezani M, Weisbart E, Bauman J, Singh A, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Leardini E, Jetley G, Pagnotta J, Haghighi M, Batista TM, Pérez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT Nature methods 39870862 Nat Methods 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39870862
An Atlas of Variant Effects to understand the genome at nucleotide resolution. Fowler DM, Adams DJ, Gloyn AL, Hahn WC, Marks DS, Muffley LA, Neal JT, Roth FP, Rubin AF, Starita LM, Hurles ME Genome biology 37394429 Genome Biol 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/37394429
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BEERS2: RNA-Seq simulation through high fidelity in silico modeling. Brooks TG, Lahens NF, Mrčela A, Sarantopoulou D, Nayak S, Naik A, Sengupta S, Choi PS, Grant GR bioRxiv : the preprint server for biology 37162982 bioRxiv 2023 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/37162982
Incomplete paralog compensation generates selective dependency on TRA2A in cancer. Lee AR, Tangiyan A, Singh I, Choi PS PLoS genetics 40367120 PLoS Genet 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40367120
Machine learning-optimized targeted detection of alternative splicing. Yang K, Islas N, Jewell S, Wu D, Jha A, Radens CM, Pleiss JA, Lynch KW, Barash Y, Choi PS Nucleic acids research 39727154 Nucleic Acids Res 2025 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/39727154
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Machine learning-optimized targeted detection of alternative splicing. Yang K, Islas N, Jewell S, Jha A, Radens CM, Pleiss JA, Lynch KW, Barash Y, Choi PS bioRxiv : the preprint server for biology 39386495 bioRxiv 2024 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/39386495
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ Nature 35395152 Nature 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35395152
Structure and assembly of a bacterial gasdermin pore. Johnson AG, Mayer ML, Schaefer SL, McNamara-Bordewick NK, Hummer G, Kranzusch PJ bioRxiv : the preprint server for biology 37131678 bioRxiv 2023 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/37131678
Structural basis of QueC-family protein function in qatABCD anti-phage defense. Gao A, Wassarman DR, Kranzusch PJ bioRxiv : the preprint server for biology 40950076 bioRxiv 2025 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/40950076
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A prophage-encoded abortive infection protein preserves host and prophage spread. Sargen MR, Antine SP, Grabe GJ, Antonellis G, Ragucci AE, Li Y, Kranzusch PJ, Helaine S Nature 41606329 Nature 2026 Apr https://www.ncbi.nlm.nih.gov/pubmed/41606329
A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion. Richmond-Buccola D, Hobbs SJ, Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, Kranzusch PJ Cell host & microbe 38917809 Cell Host Microbe 2024 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/38917809
Viral sponges sequester nucleotide signals to inactivate immunity. Richmond-Buccola D, Kranzusch PJ Trends in microbiology 37100632 Trends Microbiol 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37100632
cGLRs are a diverse family of pattern recognition receptors in innate immunity. Li Y, Slavik KM, Toyoda HC, Morehouse BR, de Oliveira Mann CC, Elek A, Levy S, Wang Z, Mears KS, Liu J, Kashin D, Guo X, Mass T, Sebé-Pedrós A, Schwede F, Kranzusch PJ Cell 37379839 Cell 2023 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/37379839
CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling. Slavik KM, Kranzusch PJ Annual review of virology 37380187 Annu Rev Virol 2023 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/37380187
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS. Scott TM, Arnold LM, Powers JA, McCann DA, Rowe AB, Christensen DE, Pereira MJ, Zhou W, Torrez RM, Iwasa JH, Kranzusch PJ, Sundquist WI, Johnson JS bioRxiv : the preprint server for biology 38712059 bioRxiv 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/38712059
Animal and bacterial viruses share conserved mechanisms of immune evasion. Hobbs SJ, Nomburg J, Doudna JA, Kranzusch PJ Cell 39197447 Cell 2024 Oct 3 https://www.ncbi.nlm.nih.gov/pubmed/39197447
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Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life. Fels JM, Hill AB, Han R, Garcia JM, Bisio H, Abergel C, Kranzusch PJ, Lee ASY bioRxiv : the preprint server for biology 41256553 bioRxiv 2025 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/41256553
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Live cell single-molecule imaging to study DNA repair in human cells. Heyza JR, Mikhova M, Schmidt JC DNA repair 37467632 DNA Repair (Amst) 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37467632
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PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress. Mashayekhi F, Ganje C, Caron MC, Heyza JR, Gao Y, Zeinali E, Fanta M, Li L, Ali J, Mersaoui SY, Schmidt JC, Godbout R, Masson JY, Weinfeld M, Ismail IH Cell reports 39671289 Cell Rep 2024 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/39671289
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells. Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC Nature communications 39578493 Nat Commun 2024 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/39578493
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Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation. Broadbent DG, Barnaba C, Perez GI, Schmidt JC The Journal of cell biology 37115157 J Cell Biol 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/37115157
Systematic analysis of the molecular and biophysical properties of key DNA damage response factors. Heyza JR, Mikhova M, Bahl A, Broadbent DG, Schmidt JC eLife 37341699 Elife 2023 Jun 21 https://www.ncbi.nlm.nih.gov/pubmed/37341699
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The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. Broadbent DG, McEwan CM, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL bioRxiv : the preprint server for biology 38077022 bioRxiv 2023 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/38077022
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Protocol for fast antibiotic resistance-based gene editing of mammalian cells with CRISPR-Cas9. Adarska P, Fox E, Heyza J, Barnaba C, Schmidt J, Bottanelli F STAR protocols 40768339 STAR Protoc 2025 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/40768339
A dynamic RNA hub facilitates activation induced cytidine deaminase recruitment to the immunoglobulin heavy chain locus. Mikhova M, Kapanka M, Han L, Schmidt JC, Yu K bioRxiv : the preprint server for biology 41648117 bioRxiv 2026 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/41648117
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Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates. Broadbent DG, McEwan CM, Jayatunge D, Kaminsky EG, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL Molecular biology of the cell 39718773 Mol Biol Cell 2025 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/39718773
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Mapping protein conformational landscapes from crystallographic drug fragment screens. Saeed AA, Klureza MA, Hekstra DR bioRxiv : the preprint server for biology 39131376 bioRxiv 2024 Jul 30 https://www.ncbi.nlm.nih.gov/pubmed/39131376
Mapping Protein Conformational Landscapes from Crystallographic Drug Fragment Screens. Saeed AA, Klureza MA, Hekstra DR Journal of chemical information and modeling 39530154 J Chem Inf Model 2024 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/39530154
AlphaFold as a Prior: Experimental Structure Determination Conditioned on a Pretrained Neural Network. Fadini A, Li M, McCoy AJ, Terwilliger TC, Read RJ, Hekstra D, AlQuraishi M bioRxiv : the preprint server for biology 40027838 bioRxiv 2025 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/40027838
Sensitive detection of structural dynamics using a statistical framework for comparative crystallography. Hekstra DR, Wang HK, Klureza MA, Greisman JB, Dalton KM Science advances 41337576 Sci Adv 2025 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/41337576
Resolving conformational changes that mediate a two-step catalytic mechanism in a model enzyme. Greisman JB, Dalton KM, Brookner DE, Klureza MA, Sheehan CJ, Kim IS, Henning RW, Russi S, Hekstra DR bioRxiv : the preprint server for biology 37398233 bioRxiv 2023 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/37398233
Insights into VDAC Gating: Room-Temperature X-ray Crystal Structure of mVDAC-1. Gonzalez-DeWhitt KR, Ermolova N, Wang HK, Hekstra DR, Althoff T, Abramson J Biomolecules 39456136 Biomolecules 2024 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/39456136
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Scaling and Merging Time-Resolved Laue Data with Variational Inference. Zielinski KA, Dolamore C, Wang HK, Henning RW, Wilson MA, Pollack L, Srajer V, Hekstra DR, Dalton KM bioRxiv : the preprint server for biology 39131362 bioRxiv 2024 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/39131362
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Programmable RNA targeting with CRISPR-Cas13. Shi P, Wu X RNA biology 38764173 RNA Biol 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38764173
Right on target: Chromatin jets arise from targeted cohesin loading in wild-type cells. Drayton JA, Hansen AS Molecular cell 36270244 Mol Cell 2022 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/36270244
Promoters adopt distinct dynamic manifestations depending on transcription factor context. Hansen AS, Zechner C Molecular systems biology 33595925 Mol Syst Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33595925
A Protocol for Studying Transcription Factor Dynamics Using Fast Single-Particle Tracking and Spot-On Model-Based Analysis. Jha A, Hansen AS Methods in molecular biology (Clifton, N.J.) 35103967 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/35103967
Enhancer-promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1. Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X, Tjian R Nature genetics 36471071 Nat Genet 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36471071
Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. Cerda-Smith CG, Hutchinson HM, Liu A, Goel VY, Sept C, Kim H, Casaní-Galdón S, Burkman KG, Bassil CF, Hansen AS, Aryee MJ, Johnstone SE, Eyler CE, Wood KC bioRxiv : the preprint server for biology 37786671 bioRxiv 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37786671
Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments. Goel VY, Huseyin MK, Hansen AS Nature genetics 37157000 Nat Genet 2023 Jun https://www.ncbi.nlm.nih.gov/pubmed/37157000
Enhancer selectivity in space and time: from enhancer-promoter interactions to promoter activation. Yang JH, Hansen AS Nature reviews. Molecular cell biology 38413840 Nat Rev Mol Cell Biol 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38413840
Dynamics of microcompartment formation at the mitosis-to-G1 transition. Goel VY, Aboreden NG, Jusuf JM, Zhang H, Mori LP, Mirny LA, Blobel GA, Banigan EJ, Hansen AS Nature structural & molecular biology 41107486 Nat Struct Mol Biol 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/41107486
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project. Dekker J, Alber F, Aufmkolk S, Beliveau BJ, Bruneau BG, Belmont AS, Bintu L, Boettiger A, Calandrelli R, Disteche CM, Gilbert DM, Gregor T, Hansen AS, Huang B, Huangfu D, Kalhor R, Leslie CS, Li W, Li Y, Ma J, Noble WS, Park PJ, Phillips-Cremins JE, Pollard KS, Rafelski SM, Ren B, Ruan Y, Shav-Tal Y, Shen Y, Shendure J, Shu X, Strambio-De-Castillia C, Vertii A, Zhang H, Zhong S Molecular cell 37419111 Mol Cell 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37419111
LDB1 establishes multi-enhancer networks to regulate gene expression. Aboreden NG, Lam JC, Goel VY, Wang S, Wang X, Midla SC, Quijano A, Keller CA, Giardine BM, Hardison RC, Zhang H, Hansen AS, Blobel GA bioRxiv : the preprint server for biology 39229045 bioRxiv 2024 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/39229045
Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function. Narducci DN, Hansen AS Molecular cell 39708803 Mol Cell 2025 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/39708803
Molecular models of bidirectional promoter regulation. Nemsick S, Hansen AS Current opinion in structural biology 38905929 Curr Opin Struct Biol 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38905929
Genome-wide absolute quantification of chromatin looping. Jusuf JM, Grosse-Holz S, Gabriele M, Mach P, Flyamer IM, Zechner C, Giorgetti L, Mirny LA, Hansen AS bioRxiv : the preprint server for biology 39935886 bioRxiv 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39935886
Editorial overview: Emerging perspectives in genome architecture and gene regulation. Nollmann M, Hansen AS Current opinion in genetics & development 40359646 Curr Opin Genet Dev 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40359646
Tracking and interpreting long-range chromatin interactions with super-resolution live-cell imaging. Brandão HB, Gabriele M, Hansen AS Current opinion in cell biology 33310227 Curr Opin Cell Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33310227
Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging. Mahadevan J, Jha A, Rudolph J, Bowerman S, Narducci D, Hansen AS, Luger K iScience 36594010 iScience 2023 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/36594010
DNA double-strand break end synapsis by DNA loop extrusion. Yang JH, Brandão HB, Hansen AS Nature communications 37024496 Nat Commun 2023 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/37024496
Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation. Do C, Jiang G, Cova G, Katsifis CC, Narducci DN, Sakellaropoulos T, Vidal R, Lhoumaud P, Tsirigos A, Regis FFD, Kakabadze N, Nora EP, Noyes M, Hansen AS, Skok JA bioRxiv : the preprint server for biology 38370764 bioRxiv 2025 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/38370764
Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging. Gabriele M, Brandão HB, Grosse-Holz S, Jha A, Dailey GM, Cattoglio C, Hsieh TS, Mirny L, Zechner C, Hansen AS Science (New York, N.Y.) 35420890 Science 2022 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/35420890
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An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing. Waterbury AL, Kwok HS, Lee C, Narducci DN, Freedy AM, Su C, Raval S, Reiter AH, Hawkins W, Lee K, Li J, Hoenig SM, Vinyard ME, Cole PA, Hansen AS, Carr SA, Papanastasiou M, Liau BB Molecular cell 38870936 Mol Cell 2024 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/38870936
Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription. Nagano M, Hansen AS Cell genomics 40081334 Cell Genom 2025 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/40081334
Dynamics of microcompartment formation at the mitosis-to-G1 transition. Goel VY, Aboreden NG, Jusuf JM, Zhang H, Mori LP, Mirny LA, Blobel GA, Banigan EJ, Hansen AS bioRxiv : the preprint server for biology 39345388 bioRxiv 2024 Sep 16 https://www.ncbi.nlm.nih.gov/pubmed/39345388
Genome structure mapping with high-resolution 3D genomics and deep learning. Hong CKY, Feng F, Ramanathan V, Liu J, Hansen AS bioRxiv : the preprint server for biology 40654659 bioRxiv 2025 May 7 https://www.ncbi.nlm.nih.gov/pubmed/40654659
Reeling it in: how DNA topology drives loop extrusion by condensin. Narducci DN, Hansen AS Nature structural & molecular biology 35835869 Nat Struct Mol Biol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35835869
Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude. Mazzocca M, Narducci DN, Grosse-Holz S, Matthias J, Hansen AS bioRxiv : the preprint server for biology 40463058 bioRxiv 2025 May 14 https://www.ncbi.nlm.nih.gov/pubmed/40463058
Genome manipulation by guide-directed Argonaute cleavage. Huang S, Wang K, Mayo SL Nucleic acids research 36928676 Nucleic Acids Res 2023 May 8 https://www.ncbi.nlm.nih.gov/pubmed/36928676
Removal of Antibiotic Resistant Bacteria and Genes by UV-Assisted Electrochemical Oxidation on Degenerative TiO(2) Nanotube Arrays. Wang S, Yang S, Quispe E, Yang H, Sanfiorenzo C, Rogers SW, Wang K, Yang Y, Hoffmann MR ACS ES&T engineering 39605952 ACS ES T Eng 2021 Mar 12 https://www.ncbi.nlm.nih.gov/pubmed/39605952
Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS. Robertson WE, Funke LFH, de la Torre D, Fredens J, Wang K, Chin JW Nature protocols 33903757 Nat Protoc 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33903757
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Large-scale discovery, analysis, and design of protein energy landscapes. Ferrari ÁJR, Dixit SM, Thibeault J, Garcia M, Houliston S, Ludwig RW, Notin P, Phoumyvong CM, Martell CM, Jung MD, Tsuboyama K, Carter L, Arrowsmith CH, Guttman M, Rocklin GJ bioRxiv : the preprint server for biology 40196533 bioRxiv 2025 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/40196533
Structural and energetic analysis of stabilizing indel mutations. Gutierrez YM, Rocklin GJ bioRxiv : the preprint server for biology 39763793 bioRxiv 2024 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/39763793
Global Analysis of Aggregation Determinants in Small Protein Domains. Martell CM, Gebis KK, Van HM, Gutierrez YM, Jung MD, Savas JN, Rocklin GJ bioRxiv : the preprint server for biology 41292870 bioRxiv 2025 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/41292870
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state. Nodelman IM, Das S, Faustino AM, Fried SD, Bowman GD, Armache JP Nature structural & molecular biology 35173352 Nat Struct Mol Biol 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35173352
How synonymous mutations alter enzyme structure and function over long timescales. Jiang Y, Neti SS, Sitarik I, Pradhan P, To P, Xia Y, Fried SD, Booker SJ, O'Brien EP Nature chemistry 36471044 Nat Chem 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36471044
A proteome-wide map of chaperone-assisted protein refolding in a cytosol-like milieu. To P, Xia Y, Lee SO, Devlin T, Fleming KG, Fried SD Proceedings of the National Academy of Sciences of the United States of America 36417429 Proc Natl Acad Sci U S A 2022 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/36417429
Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles. Vu QV, Sitarik I, Jiang Y, Xia Y, Sharma P, Yadav D, Song H, Li MS, Fried SD, O'Brien EP Science advances 40779622 Sci Adv 2025 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/40779622
Investigation of the global translational response to oxidative stress in the model archaeon Haloferax volcanii reveals untranslated small RNAs with ribosome occupancy. Dallon E, Moran HM, Chidambaran SR, Kian A, Huang BYH, Fried SD, DiRuggiero J mSphere 40920071 mSphere 2025 Sep 30 https://www.ncbi.nlm.nih.gov/pubmed/40920071
Investigation of the global translational response to oxidative stress in the model archaeon Haloferax volcanii reveals untranslated small RNAs with ribosome occupancy. Dallon E, Moran HM, Chidambaran SR, Kian A, Huang BYH, Fried SD, DiRuggiero J bioRxiv : the preprint server for biology 40672279 bioRxiv 2025 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/40672279
Chaperone Dependency during Primary Protein Biogenesis Does Not Correlate with Chaperone Dependency during in vitro Refolding. Yadav D, Demiralp İI, Fakler M, Fried SD bioRxiv : the preprint server for biology 40611891 bioRxiv 2025 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/40611891
Intracellular Formation of a DNA Damage-Induced, Histone Post-Translational Modification Following Bleomycin Treatment. Jacinto MP, Fried SD, Greenberg MM Journal of the American Chemical Society 35467863 J Am Chem Soc 2022 May 4 https://www.ncbi.nlm.nih.gov/pubmed/35467863
Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements. Lan PD, Nissley DA, Sitarik I, Vu QV, Jiang Y, To P, Xia Y, Fried SD, Li MS, O'Brien EP Journal of molecular biology 38341172 J Mol Biol 2024 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/38341172
Early Selection of the Amino Acid Alphabet Was Adaptively Shaped by Biophysical Constraints of Foldability. Makarov M, Sanchez Rocha AC, Krystufek R, Cherepashuk I, Dzmitruk V, Charnavets T, Faustino AM, Lebl M, Fujishima K, Fried SD, Hlouchova K Journal of the American Chemical Society 36826345 J Am Chem Soc 2023 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/36826345
Secretion-Catalyzed Assembly of Protein Biomaterials on a Bacterial Membrane Surface. Xie Q, On Lee S, Vissamsetti N, Guo S, Johnson ME, Fried SD Angewandte Chemie (International ed. in English) 37469298 Angew Chem Int Ed Engl 2023 Sep 11 https://www.ncbi.nlm.nih.gov/pubmed/37469298
FLiPPR: A Processor for Limited Proteolysis (LiP) Mass Spectrometry Data Sets Built on FragPipe. Manriquez-Sandoval E, Brewer J, Lule G, Lopez S, Fried SD Journal of proteome research 38787630 J Proteome Res 2024 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/38787630
Cognition-Associated Protein Structural Changes in a Rat Model of Aging are Related to Reduced Refolding Capacity. Tarbox HE, Branch A, Fried SD bioRxiv : the preprint server for biology 39386726 bioRxiv 2024 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/39386726
Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity. Tarbox HE, Branch A, Fried SD Science advances 40644533 Sci Adv 2025 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/40644533
Phosphoglycerate Kinase Can Adopt a Topologically Misfolded Form that is More Stable than its Native State. Xia Y, Amann B, Gillilan RE, Sharma P, Sen S, Fleming KG, Fried SD bioRxiv : the preprint server for biology 40667093 bioRxiv 2025 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/40667093
Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures. Makarov M, Kryštůfek R, Friček M, Manriquez-Sandoval E, Dutta S, Kormaník JM, Kalvoda T, Verner V, Bednárová L, Charnavets T, Lebl M, Brown SM, Hadravová R, Konvalinka J, Singharoy A, Fried SD, Hlouchová K bioRxiv : the preprint server for biology 41292710 bioRxiv 2025 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/41292710
Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional. Nissley DA, Jiang Y, Trovato F, Sitarik I, Narayan KB, To P, Xia Y, Fried SD, O'Brien EP Nature communications 35654797 Nat Commun 2022 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/35654797
Progress toward Proteome-Wide Photo-Cross-Linking to Enable Residue-Level Visualization of Protein Structures and Networks In Vivo. Faustino AM, Sharma P, Manriquez-Sandoval E, Yadav D, Fried SD Analytical chemistry 37341467 Anal Chem 2023 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/37341467
Protein surface chemistry encodes an adaptive tolerance to desiccation. Romero-Pérez PS, Moran HM, Cordone DP Jr, Horani A, Truong A, Manriquez-Sandoval E, Ramirez JF, Martinez A, Gollub E, Hunter K, Kolamunna KC, Lotthammer JM, Emenecker RJ, Liu H, Iwasa JH, Boothby TC, Holehouse AS, Fried SD, Sukenik S Cell systems 41043424 Cell Syst 2025 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/41043424
Phase separation of PGL-3 driven by structured domains that oligomerize and interact with terminal RGG motifs. Kuroiwa R, Sharma P, Putnam A, Fried SD, Seydoux G bioRxiv : the preprint server for biology 40666952 bioRxiv 2025 Jun 24 https://www.ncbi.nlm.nih.gov/pubmed/40666952
Proteome-Wide Assessment of Protein Structural Perturbations Under High Pressure. Moran HM, Manriquez-Sandoval E, Sharma P, Fried SD, Gillilan RE PRX life 40491869 PRX Life 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/40491869
An intrinsically disordered region of Ubp10 regulates its binding and activity on ubiquitinated histone substrates. Faustino AM, Nune M, Merino-Urteaga R, Manriquez-Sandoval E, Poyton M, Ha T, Wolberger C, Fried SD Protein science : a publication of the Protein Society 40716115 Protein Sci 2025 Aug https://www.ncbi.nlm.nih.gov/pubmed/40716115
Phase separation of PGL-3 driven by structured domains that oligomerize and interact with RGG motifs. Kuroiwa R, Sharma P, Putnam AA, Fried SD, Seydoux G EMBO reports 41862773 EMBO Rep 2026 Mar 20 https://www.ncbi.nlm.nih.gov/pubmed/41862773
Nonrefoldability is Pervasive Across the E. coli Proteome. To P, Whitehead B, Tarbox HE, Fried SD Journal of the American Chemical Society 34308638 J Am Chem Soc 2021 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/34308638
FLiPPR: A Processor for Limited Proteolysis (LiP) Mass Spectrometry Datasets Built on FragPipe. Manriquez-Sandoval E, Brewer J, Lule G, Lopez S, Fried SD bioRxiv : the preprint server for biology 38106106 bioRxiv 2023 Dec 5 https://www.ncbi.nlm.nih.gov/pubmed/38106106
Cryo-EM structures of plant Augmin reveal coiled-coil assembly, antiparallel dimerization, and NEDD1 binding. Ashaduzzaman M, Taheri A, Lee YJ, Tang Y, Mittal S, Guo F, Morcos F, Fried SD, Liu B, Al-Bassam J Nature communications 41387433 Nat Commun 2025 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/41387433
Protein misfolding involving entanglements providesa structural explanation for the origin of stretched-exponential refolding kinetics. Jiang Y, Xia Y, Sitarik I, Sharma P, Song H, Fried SD, O'Brien EP Science advances 40085700 Sci Adv 2025 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/40085700
Cryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms. Ashaduzzaman M, Taheri A, Lee YJ, Tang Y, Guo F, Fried SD, Liu B, Al-Bassam J bioRxiv : the preprint server for biology 40034650 bioRxiv 2025 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/40034650
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS Cell 35688146 Cell 2022 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/35688146
Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome. Metzner E, Southard KM, Norman TM bioRxiv : the preprint server for biology 39091800 bioRxiv 2024 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/39091800
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states. Southard KM, Ardy RC, Tang A, O'Sullivan DD, Metzner E, Guruvayurappan K, Norman TM Nature genetics 40770575 Nat Genet 2025 Sep https://www.ncbi.nlm.nih.gov/pubmed/40770575
Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome. Metzner E, Southard KM, Norman TM Cell systems 39689711 Cell Syst 2025 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/39689711
Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation. Herken BW, Wong GT, Mäkiniemi A, Lundberg E, Norman TM, Gilbert LA Molecular cell 41720076 Mol Cell 2026 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/41720076
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Accessing the human trophoblast stem cell state from pluripotent and somatic cells. Karvas RM, David L, Theunissen TW Cellular and molecular life sciences : CMLS 36434136 Cell Mol Life Sci 2022 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/36434136
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens. Karvas RM, Khan SA, Verma S, Yin Y, Kulkarni D, Dong C, Park KM, Chew B, Sane E, Fischer LA, Kumar D, Ma L, Boon ACM, Dietmann S, Mysorekar IU, Theunissen TW Cell stem cell 35523141 Cell Stem Cell 2022 May 5 https://www.ncbi.nlm.nih.gov/pubmed/35523141
A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Dong C, Fu S, Karvas RM, Chew B, Fischer LA, Xing X, Harrison JK, Popli P, Kommagani R, Wang T, Zhang B, Theunissen TW Nature communications 35538076 Nat Commun 2022 May 10 https://www.ncbi.nlm.nih.gov/pubmed/35538076
Generating Trophoblast Stem Cells from Human Naïve Pluripotent Stem Cells. Dong C, Theunissen TW Methods in molecular biology (Clifton, N.J.) 34870832 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/34870832
Modeling X-chromosome inactivation and reactivation during human development. Khan SA, Theunissen TW Current opinion in genetics & development 37597506 Curr Opin Genet Dev 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37597506
iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation. Morey R, Bui T, Cheung VC, Dong C, Zemke JE, Requena D, Arora H, Jackson MG, Pizzo D, Theunissen TW, Horii M iScience 38623329 iScience 2024 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/38623329
ORF3a is a key driver of maternal SARS-CoV-2 infection-associated placental dysfunction. Mysorekar I, Kumar D, McColl E, Karvas R, Jones B, Tran L, Diveley E, Jash S, Sharma S, Kelly J, Theunissen T Research square 40630515 Res Sq 2025 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/40630515
Trophoblast ferroptosis restricts SARS-CoV-2 spread in the placenta. McColl ER, Kumar D, Jones BR, Marks N, Diveley E, Karvas R, Theunissen TW, Kelly JC, Mysorekar IU bioRxiv : the preprint server for biology 41659473 bioRxiv 2026 Jan 26 https://www.ncbi.nlm.nih.gov/pubmed/41659473
Recent insights into the naïve state of human pluripotency and its applications. Dong C, Fischer LA, Theunissen TW Experimental cell research 31585117 Exp Cell Res 2019 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/31585117
Generation of 3D Trophoblast Organoids from Human Naïve Pluripotent Stem Cells. Karvas RM, Theunissen TW Methods in molecular biology (Clifton, N.J.) 37402094 Methods Mol Biol 2024 https://www.ncbi.nlm.nih.gov/pubmed/37402094
Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening. Khan SA, Park KM, Fischer LA, Dong C, Lungjangwa T, Jimenez M, Casalena D, Chew B, Dietmann S, Auld DS, Jaenisch R, Theunissen TW Cell reports 34133938 Cell Rep 2021 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/34133938
Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution. Fischer LA, Meyer B, Reyes M, Zemke JE, Harrison JK, Park KM, Wang T, Jüppner H, Dietmann S, Theunissen TW Stem cell reports 39952244 Stem Cell Reports 2025 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/39952244
Derivation of trophoblast stem cells from naïve human pluripotent stem cells. Dong C, Beltcheva M, Gontarz P, Zhang B, Popli P, Fischer LA, Khan SA, Park KM, Yoon EJ, Xing X, Kommagani R, Wang T, Solnica-Krezel L, Theunissen TW eLife 32048992 Elife 2020 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/32048992
OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Huang X, Park KM, Gontarz P, Zhang B, Pan J, McKenzie Z, Fischer LA, Dong C, Dietmann S, Xing X, Shliaha PV, Yang J, Li D, Ding J, Lungjangwa T, Mitalipova M, Khan SA, Imsoonthornruksa S, Jensen N, Wang T, Kadoch C, Jaenisch R, Wang J, Theunissen TW Nature communications 34446700 Nat Commun 2021 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/34446700
SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids. Kumar D, Karvas RM, Jones BR, McColl ER, Diveley E, Sukanta J, Surendra S, Kelly JC, Theunissen TW, Mysorekar IU bioRxiv : the preprint server for biology 39386577 bioRxiv 2024 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/39386577
Biomaterials to enhance stem cell transplantation. Kharbikar BN, Mohindra P, Desai TA Cell stem cell 35483364 Cell Stem Cell 2022 May 5 https://www.ncbi.nlm.nih.gov/pubmed/35483364
Induction of Human Naïve Pluripotency Using 5i/L/A Medium. Fischer LA, Khan SA, Theunissen TW Methods in molecular biology (Clifton, N.J.) 34870827 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/34870827
l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate. Kumar P, Meza A, Ellis JM, Carlson GA, Bingman CA, Buller AR ACS chemical biology 33337128 ACS Chem Biol 2021 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/33337128
Active site diversification of a non-canonical amino acid decarboxylase by merging substrate multiplexed screening with computationally guided recombination. McDonald AD, Ellis JM, Steger-Wilson L, Campbell ME, Buller AR Protein science : a publication of the Protein Society 41123281 Protein Sci 2025 Nov https://www.ncbi.nlm.nih.gov/pubmed/41123281
Substrate-Multiplexed Assessment of Aromatic Prenyltransferase Activity. Higgins PM, Wehrli NG, Buller AR Chembiochem : a European journal of chemical biology 39317170 Chembiochem 2025 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/39317170
Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis. McDonald AD, Higgins PM, Buller AR Nature communications 36068220 Nat Commun 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/36068220
Scalable and Selective β-Hydroxy-α-Amino Acid Synthesis Catalyzed by Promiscuous l-Threonine Transaldolase ObiH. Doyon TJ, Kumar P, Thein S, Kim M, Stitgen A, Grieger AM, Madigan C, Willoughby PH, Buller AR Chembiochem : a European journal of chemical biology 34699683 Chembiochem 2022 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/34699683
Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB. Watkins-Dulaney EJ, Dunham NP, Straathof S, Turi S, Arnold FH, Buller AR Angewandte Chemie (International ed. in English) 34269506 Angew Chem Int Ed Engl 2021 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/34269506
Engineered Biocatalytic Synthesis of β-N-Substituted-α-Amino Acids. Villalona J, Higgins PM, Buller AR Angewandte Chemie (International ed. in English) 37625129 Angew Chem Int Ed Engl 2023 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/37625129
Biocatalytic asymmetric aldol addition into unactivated ketones. Bruffy SK, Meza A, Soler J, Doyon TJ, Young SH, Lim J, Huseth KG, Willoughby PH, Garcia-Borràs M, Buller AR Nature chemistry 39333392 Nat Chem 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39333392
Promiscuity Guided Evolution of Decarboxylative Aldolases for Synthesis of Tertiary γ-Hydroxy Amino Acids. Campbell ME, Ohler AR, McGill MJ, Buller AR Angewandte Chemie (International ed. in English) 39874202 Angew Chem Int Ed Engl 2025 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/39874202
Chemoenzymatic Cascade Synthesis of Metal-Chelating α-Amino Acids. Young SH, Andon JS, Lim J, Franke MC, Weix DJ, Wang T, Buller AR ChemCatChem 40761323 ChemCatChem 2025 Mar 6 https://www.ncbi.nlm.nih.gov/pubmed/40761323
Modular control of l-tryptophan isotopic substitution via an efficient biosynthetic cascade. Thompson CM, McDonald AD, Yang H, Cavagnero S, Buller AR Organic & biomolecular chemistry 32452506 Org Biomol Chem 2020 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/32452506
Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family. Zmich A, Perkins LJ, Bingman C, Acheson JF, Buller AR ACS catalysis 37720819 ACS Catal 2023 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/37720819
Engineering Enzyme Substrate Scope Complementarity for Promiscuous Cascade Synthesis of 1,2-Amino Alcohols. McDonald AD, Bruffy SK, Kasat AT, Buller AR Angewandte Chemie (International ed. in English) 36136093 Angew Chem Int Ed Engl 2022 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/36136093
Occupational modulation in the (3+1)-dimensional incommensurate structure of (2S,3S)-2-amino-3-hydroxy-3-methyl-4-phenoxybutanoic acid dihydrate. Sanders KM, Bruffy SK, Buller AR, Petříček V, Guzei IA Acta crystallographica. Section C, Structural chemistry 39115533 Acta Crystallogr C Struct Chem 2024 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/39115533
Biocatalytic synthesis of non-standard amino acids by a decarboxylative aldol reaction. Ellis JM, Campbell ME, Kumar P, Geunes EP, Bingman CA, Buller AR Nature catalysis 35935533 Nat Catal 2022 Feb https://www.ncbi.nlm.nih.gov/pubmed/35935533
Elucidation of the stereochemical mechanism of cystathionine γ-lyase reveals how substrate specificity constrains catalysis. Zmich A, Perkins LJ, Bingman C, Buller AR ACS catalysis 39391268 ACS Catal 2024 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/39391268
Site-Selective Deuteration of Amino Acids through Dual-Protein Catalysis. Doyon TJ, Buller AR Journal of the American Chemical Society 35416652 J Am Chem Soc 2022 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/35416652
Investigation of β-Substitution Activity of O-Acetylserine Sulfhydrolase from Citrullus vulgaris. Smith JL, Harrison IM, Bingman CA, Buller AR Chembiochem : a European journal of chemical biology 35476889 Chembiochem 2022 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/35476889
Efficient chemoenzymatic synthesis of α-aryl aldehydes as intermediates in C-C bond forming biocatalytic cascades. Meza A, Campbell ME, Zmich A, Thein SA, Grieger AM, McGill MJ, Willoughby PH, Buller AR ACS catalysis 36420479 ACS Catal 2022 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/36420479
Highly Sensitive Detection of Tyrosine and Neurotransmitters by Stereoselective Biosynthesis and Photochemically Induced Dynamic Nuclear Polarization. Shapla UM, Smith JL, Halder A, Thompson L, Buller AR, Cavagnero S Journal of the American Chemical Society 41190608 J Am Chem Soc 2025 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/41190608
Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Garcia G, Bar-Ziv R, Averbukh M, Dasgupta N, Dutta N, Zhang H, Fan W, Moaddeli D, Tsui CK, Castro Torres T, Alcala A, Moehle EA, Hoang S, Shalem O, Adams PD, Thorwald MA, Higuchi-Sanabria R Aging cell 36404134 Aging Cell 2023 Jan https://www.ncbi.nlm.nih.gov/pubmed/36404134
High-throughput optimized prime editing mediated endogenous protein tagging for pooled imaging of protein localization. Sanchez HM, Lapidot T, Shalem O bioRxiv : the preprint server for biology 39345511 bioRxiv 2024 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/39345511
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses. Sansbury SE, Serebrenik YV, Lapidot T, Burslem GM, Shalem O bioRxiv : the preprint server for biology 37503003 bioRxiv 2023 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/37503003
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins. Viera Ortiz AP, Cajka G, Olatunji OA, Mikytuck B, Shalem O, Lee EB Brain : a journal of neurology 36516294 Brain 2023 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/36516294
Efficient and flexible tagging of endogenous genes by homology-independent intron targeting. Serebrenik YV, Sansbury SE, Kumar SS, Henao-Mejia J, Shalem O Genome research 31239279 Genome Res 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31239279
Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics. Serebrenik YV, Mani D, Maujean T, Burslem GM, Shalem O Research square 37790450 Res Sq 2023 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/37790450
Intracellular Protein Editing to Enable Incorporation of Non-Canonical Residues into Endogenous Proteins. Beyer JN, Serebrenik YV, Toy K, Najar MA, Raniszewski NR, Shalem O, Burslem GM bioRxiv : the preprint server for biology 39026884 bioRxiv 2024 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/39026884
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CRISPR screen for rAAV production implicates genes associated with infection. O'Driscoll EE, Arora S, Lang JF, Davidson BL, Shalem O bioRxiv : the preprint server for biology 39345423 bioRxiv 2024 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/39345423
CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB-specific degradation. Cajka G, Liu M, Shalem O bioRxiv : the preprint server for biology 39464063 bioRxiv 2024 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/39464063
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CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. Sweeney KM, Chantarawong S, Barbieri EM, Cajka G, Liu M, Spruce L, Fazelinia H, Portz B, Copley K, Lapidot T, Duhamel L, Greenwald P, Saida N, Shalgi R, Shorter J, Shalem O PLoS genetics 38315730 PLoS Genet 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38315730
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Santhosh Kumar S, Naseri NN, Pather SR, Hallacli E, Ndayisaba A, Buenaventura C, Acosta K, Roof J, Fazelinia H, Spruce LA, Luk K, Khurana V, Rhoades E, Shalem O Science advances 38335281 Sci Adv 2024 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/38335281
Structural insights into metazoan pretargeting GET complexes. Keszei AFA, Yip MCJ, Hsieh TC, Shao S Nature structural & molecular biology 34887561 Nat Struct Mol Biol 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34887561
The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization. McKenna MJ, Shao S Cold Spring Harbor perspectives in biology 36041782 Cold Spring Harb Perspect Biol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36041782
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Mechanism of ASF1 Inhibition by CDAN1. Sedor SF, Shao S bioRxiv : the preprint server for biology 39149339 bioRxiv 2024 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/39149339
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling. Zhou C, Zhang M, Murray J, Paulo J, Gygi S, Shao S, Whitman M, Keller T Science (New York, N.Y.) 41037622 Science 2025 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/41037622
ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control. Yip MCJ, Savickas S, Gygi SP, Shao S Cell reports 32075755 Cell Rep 2020 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/32075755
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase. McKenna MJ, Sim SI, Ordureau A, Wei L, Harper JW, Shao S, Park E Science (New York, N.Y.) 32973005 Science 2020 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/32973005
The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center. Coelho JPL, Yip MCJ, Oltion K, Taunton J, Shao S Nature chemical biology 38172604 Nat Chem Biol 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38172604
Detecting and Rescuing Stalled Ribosomes. Yip MCJ, Shao S Trends in biochemical sciences 33966939 Trends Biochem Sci 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/33966939
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Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation. Koga Y, Hoang EM, Park Y, Keszei AFA, Murray J, Shao S, Liau BB Journal of the American Chemical Society 34403584 J Am Chem Soc 2021 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/34403584
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Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome. Wang SE, Cheng Y, Lim J, Jang MA, Forrest EN, Kim Y, Donahue M, Jo S, Qiao SN, Lee DE, Hong JY, Xiong Y, Jin J, Wang S, Jiang YH Nature communications 40610428 Nat Commun 2025 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/40610428
Regulation of gene editing using T-DNA concatenation. Dickinson L, Yuan W, LeBlanc C, Thomson G, Wang S, Jacob Y Nature plants 37653336 Nat Plants 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37653336
Perturb-tracing enables high-content screening of multi-scale 3D genome regulators. Cheng Y, Hu M, Yang B, Jensen TB, Zhang Y, Yang T, Yu R, Ma Z, Radda JSD, Jin S, Zang C, Wang S Nature methods 40211002 Nat Methods 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40211002
Chromatin Tracing: Imaging 3D Genome and Nucleome. Hu M, Wang S Trends in cell biology 33191055 Trends Cell Biol 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33191055
Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery. Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Rajaei M, Townsend JP, Muzumdar MD, Wang S bioRxiv : the preprint server for biology 37546882 bioRxiv 2024 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/37546882
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration. Boraas LC, Hu M, Martino P, Thornton L, Vejnar CE, Zhen G, Zeng L, Parker DM, Cox AL, Giraldez AJ, Su X, Mayr C, Wang S, Nicoli S Cell reports 39883578 Cell Rep 2025 Feb 25 https://www.ncbi.nlm.nih.gov/pubmed/39883578
Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos. Sawh AN, Shafer MER, Su JH, Zhuang X, Wang S, Mango SE Molecular cell 32105612 Mol Cell 2020 Apr 2 https://www.ncbi.nlm.nih.gov/pubmed/32105612
Chromatin tracing and multiplexed imaging of nucleome architectures (MINA) and RNAs in single mammalian cells and tissue. Liu M, Yang B, Hu M, Radda JSD, Chen Y, Jin S, Cheng Y, Wang S Nature protocols 33903756 Nat Protoc 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33903756
TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations. Cheng Y, Liu M, Hu M, Wang S Genome biology 34749781 Genome Biol 2021 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/34749781
New mechanism of chromatin compartmentalization by BRD2. Cheng Y, Wang S Trends in genetics : TIG 35811175 Trends Genet 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/35811175
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An integrated platform for high-throughput nanoscopy. Barentine AES, Lin Y, Courvan EM, Kidd P, Liu M, Balduf L, Phan T, Rivera-Molina F, Grace MR, Marin Z, Lessard M, Rios Chen J, Wang S, Neugebauer KM, Bewersdorf J, Baddeley D Nature biotechnology 36914886 Nat Biotechnol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/36914886
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome. Wang SE, Cheng Y, Lim J, Jang MA, Forrest EN, Kim Y, Donahue M, Qiao SN, Xiong Y, Jin J, Wang S, Jiang YH Research square 39011107 Res Sq 2024 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/39011107
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Rajaei M, Li FY, Townsend JP, Muzumdar MD, Wang S Nature genetics 40825871 Nat Genet 2025 Dec https://www.ncbi.nlm.nih.gov/pubmed/40825871
Sequencing-free whole genome spatial transcriptomics at molecular resolution in intact tissue. Cheng Y, Dang S, Zhang Y, Chen Y, Yu R, Liu M, Jin S, Han A, Katz S, Wang S bioRxiv : the preprint server for biology 40161724 bioRxiv 2025 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/40161724
Cotranslational molecular condensation of cochaperones and assembly factors facilitates axonemal dynein biogenesis. Li Y, Xu W, Cheng Y, Djenoune L, Zhuang C, Cox AL, Britto CJ, Yuan S, Wang S, Sun Z Proceedings of the National Academy of Sciences of the United States of America 39541357 Proc Natl Acad Sci U S A 2024 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/39541357
Multiplexed imaging of nucleome architectures in single cells of mammalian tissue. Liu M, Lu Y, Yang B, Chen Y, Radda JSD, Hu M, Katz SG, Wang S Nature communications 32518300 Nat Commun 2020 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/32518300
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Female naïve human pluripotent stem cells carry X chromosomes with Xa-like and Xi-like folding conformations. Patterson B, Yang B, Tanaka Y, Kim KY, Cakir B, Xiang Y, Kim J, Wang S, Park IH Science advances 37540754 Sci Adv 2023 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/37540754
Image-based 3D genomics through chromatin tracing. Yang T, Wang S Nature reviews. Methods primers 40756061 Nat Rev Methods Primers 2024 https://www.ncbi.nlm.nih.gov/pubmed/40756061
A Metabolome- and Metagenome-Wide Association Network Reveals Microbial Natural Products and Microbial Biotransformation Products from the Human Microbiota. Cao L, Shcherbin E, Mohimani H mSystems 31455639 mSystems 2019 Aug 27 https://www.ncbi.nlm.nih.gov/pubmed/31455639
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery. Behsaz B, Bode E, Gurevich A, Shi YN, Grundmann F, Acharya D, Caraballo-Rodríguez AM, Bouslimani A, Panitchpakdi M, Linck A, Guan C, Oh J, Dorrestein PC, Bode HB, Pevzner PA, Mohimani H Nature communications 34050176 Nat Commun 2021 May 28 https://www.ncbi.nlm.nih.gov/pubmed/34050176
An interpretable machine learning approach to identify mechanism of action of antibiotics. Mongia M, Guler M, Mohimani H Scientific reports 35725893 Sci Rep 2022 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/35725893
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Bacillus subtilis biofilm matrix components target seed oil bodies to promote growth and anti-fungal resistance in melon. Berlanga-Clavero MV, Molina-Santiago C, Caraballo-Rodríguez AM, Petras D, Díaz-Martínez L, Pérez-García A, de Vicente A, Carrión VJ, Dorrestein PC, Romero D Nature microbiology 35668112 Nat Microbiol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35668112
Feature-based molecular networking in the GNPS analysis environment. Nothias LF, Petras D, Schmid R, Dührkop K, Rainer J, Sarvepalli A, Protsyuk I, Ernst M, Tsugawa H, Fleischauer M, Aicheler F, Aksenov AA, Alka O, Allard PM, Barsch A, Cachet X, Caraballo-Rodriguez AM, Da Silva RR, Dang T, Garg N, Gauglitz JM, Gurevich A, Isaac G, Jarmusch AK, Kameník Z, Kang KB, Kessler N, Koester I, Korf A, Le Gouellec A, Ludwig M, Martin H C, McCall LI, McSayles J, Meyer SW, Mohimani H, Morsy M, Moyne O, Neumann S, Neuweger H, Nguyen NH, Nothias-Esposito M, Paolini J, Phelan VV, Pluskal T, Quinn RA, Rogers S, Shrestha B, Tripathi A, van der Hooft JJJ, Vargas F, Weldon KC, Witting M, Yang H, Zhang Z, Zubeil F, Kohlbacher O, Böcker S, Alexandrov T, Bandeira N, Wang M, Dorrestein PC Nature methods 32839597 Nat Methods 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32839597
Large scale sequence alignment via efficient inference in generative models. Mongia M, Shen C, Davoodi AG, Marçais G, Mohimani H Scientific reports 37142645 Sci Rep 2023 May 4 https://www.ncbi.nlm.nih.gov/pubmed/37142645
A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data. Zuffa S, Schmid R, Bauermeister A, Gomes PWP, Caraballo-Rodriguez AM, Abiead YE, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, de Cassia Pessotti R, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Dos Santos MS, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, de León AVP, Pope PB, Rosa SL, Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC Research square 37577622 Res Sq 2023 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/37577622
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data. Zuffa S, Schmid R, Bauermeister A, P Gomes PW, Caraballo-Rodriguez AM, El Abiead Y, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, Pessotti RC, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Silva Dos Santos M, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, Vera Ponce de León A, Pope PB, La Rosa SL, La Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC Nature microbiology 38316926 Nat Microbiol 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38316926
The undiscovered natural product potential of Actinomycetes. Caraballo-Rodríguez AM, Cumsille A, Magyari S, Taboada-Alquerque M, Behsaz B, Leão TF, Broders K, El Abiead Y, Clement JA, Charron-Lamoureux V, Zuffa S, Nothias LF, Hu M, Leone C, Kakhkhorov SA, Cámara B, Mohimani H, Dorrestein PC The Journal of antibiotics 41331045 J Antibiot (Tokyo) 2026 Feb https://www.ncbi.nlm.nih.gov/pubmed/41331045
Chemical Gradients of Plant Substrates in an Atta texana Fungus Garden. Caraballo-Rodríguez AM, Puckett SP, Kyle KE, Petras D, da Silva R, Nothias LF, Ernst M, van der Hooft JJJ, Tripathi A, Wang M, Balunas MJ, Klassen JL, Dorrestein PC mSystems 34342533 mSystems 2021 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/34342533
Repository scale classification and decomposition of tandem mass spectral data. Mongia M, Mohimani H Scientific reports 33859284 Sci Rep 2021 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/33859284
Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence. Molina-Santiago C, Vela-Corcía D, Petras D, Díaz-Martínez L, Pérez-Lorente AI, Sopeña-Torres S, Pearson J, Caraballo-Rodríguez AM, Dorrestein PC, de Vicente A, Romero D Cell reports 34320359 Cell Rep 2021 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/34320359
MolDiscovery: learning mass spectrometry fragmentation of small molecules. Cao L, Guler M, Tagirdzhanov A, Lee YY, Gurevich A, Mohimani H Nature communications 34140479 Nat Commun 2021 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/34140479
Seq2Saccharide: Discovering Oligosaccharides and Aminoglycosides Natural Products by Integrating Computational Mass Spectrometry and Genome Mining. Yan D, Behsaz B, Li Y, Wang X, Skala L, Liu S, Lew HW, Guler M, Jayaprakash H, Zhou M, Cao L, Tripathi A, Clement JA, Mahmud T, Kersten RD, Mohimani H Journal of the American Chemical Society 40964993 J Am Chem Soc 2025 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/40964993
MS2Planner: improved fragmentation spectra coverage in untargeted mass spectrometry by iterative optimized data acquisition. Zuo Z, Cao L, Nothia LF, Mohimani H Bioinformatics (Oxford, England) 34252948 Bioinformatics 2021 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/34252948
EnHiC: learning fine-resolution Hi-C contact maps using a generative adversarial framework. Hu Y, Ma W Bioinformatics (Oxford, England) 34252966 Bioinformatics 2021 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/34252966
Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS. Yan D, Zhou M, Adduri A, Zhuang Y, Guler M, Liu S, Shin H, Kovach T, Oh G, Liu X, Deng Y, Wang X, Cao L, Sherman DH, Schultz PJ, Kersten RD, Clement JA, Tripathi A, Behsaz B, Mohimani H Nature communications 38918378 Nat Commun 2024 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/38918378
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cao L, Gurevich A, Alexander KL, Naman CB, Leão T, Glukhov E, Luzzatto-Knaan T, Vargas F, Quinn R, Bouslimani A, Nothias LF, Singh NK, Sanders JG, Benitez RAS, Thompson LR, Hamid MN, Morton JT, Mikheenko A, Shlemov A, Korobeynikov A, Friedberg I, Knight R, Venkateswaran K, Gerwick WH, Gerwick L, Dorrestein PC, Pevzner PA, Mohimani H Cell systems 31629686 Cell Syst 2019 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/31629686
De Novo Peptide Sequencing Reveals Many Cyclopeptides in the Human Gut and Other Environments. Behsaz B, Mohimani H, Gurevich A, Prjibelski A, Fisher M, Vargas F, Smarr L, Dorrestein PC, Mylne JS, Pevzner PA Cell systems 31864964 Cell Syst 2020 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/31864964
HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search. Lee YY, Guler M, Chigumba DN, Wang S, Mittal N, Miller C, Krummenacher B, Liu H, Cao L, Kannan A, Narayan K, Slocum ST, Roth BL, Gurevich A, Behsaz B, Kersten RD, Mohimani H Nature communications 37452020 Nat Commun 2023 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/37452020
Structural basis for membrane insertion by the human ER membrane protein complex. Pleiner T, Tomaleri GP, Januszyk K, Inglis AJ, Hazu M, Voorhees RM Science (New York, N.Y.) 32439656 Science 2020 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/32439656
Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex. Inglis AJ, Page KR, Guna A, Voorhees RM Cell reports 32187542 Cell Rep 2020 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/32187542
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM bioRxiv : the preprint server for biology 36711738 bioRxiv 2023 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/36711738
A selectivity filter in the ER membrane protein complex limits protein misinsertion at the ER. Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM The Journal of cell biology 37199759 J Cell Biol 2023 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/37199759
A nanobody-based strategy for rapid and scalable purification of human protein complexes. Stevens TA, Tomaleri GP, Hazu M, Wei S, Nguyen VN, DeKalb C, Voorhees RM, Pleiner T Nature protocols 37974029 Nat Protoc 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/37974029
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens. Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM BMC genomics 37904134 BMC Genomics 2023 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/37904134
WNK1 is an assembly factor for the human ER membrane protein complex. Pleiner T, Hazu M, Tomaleri GP, Januszyk K, Oania RS, Sweredoski MJ, Moradian A, Guna A, Voorhees RM Molecular cell 33964204 Mol Cell 2021 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/33964204
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum. Guna A, Hazu M, Pinton Tomaleri G, Voorhees RM Cold Spring Harbor perspectives in biology 36041783 Cold Spring Harb Perspect Biol 2023 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/36041783
3D ATAC-PALM: super-resolution imaging of the accessible genome. Xie L, Dong P, Chen X, Hsieh TS, Banala S, De Marzio M, English BP, Qi Y, Jung SK, Kieffer-Kwon KR, Legant WR, Hansen AS, Schulmann A, Casellas R, Zhang B, Betzig E, Lavis LD, Chang HY, Tjian R, Liu Z Nature methods 32203384 Nat Methods 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32203384
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms. Fu TM, Liu G, Milkie DE, Ruan X, Görlitz F, Shi Y, Ferro V, Divekar NS, Wang W, York HM, Kilic V, Mueller M, Liang Y, Daugird TA, Gacha-Garay MJ, Larkin KA, Adikes RC, Harrison N, Shirazinejad C, Williams S, Nourse JL, Sheu SH, Gao L, Li T, Mondal C, Achour K, Hercule W, Stabley D, Emmerich K, Dong P, Drubin D, Liu ZJ, Clapham D, Mumm JS, Koyama M, Killilea A, Bravo-Cordero JJ, Keene CD, Luo L, Kirchhausen T, Pathak MM, Arumugam S, Nunez JK, Gao R, Matus DQ, Martin BL, Swinburne IA, Betzig E, Legant WR, Upadhyayula S bioRxiv : the preprint server for biology 40661351 bioRxiv 2025 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/40661351
Superresolution microscopy reveals actomyosin dynamics in medioapical arrays. Moore RP, Fogerson SM, Tulu US, Yu JW, Cox AH, Sican MA, Li D, Legant WR, Weigel AV, Crawford JM, Betzig E, Kiehart DP Molecular biology of the cell 35544300 Mol Biol Cell 2022 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/35544300
A quantitative analysis of various patterns applied in lattice light sheet microscopy. Shi Y, Daugird TA, Legant WR Nature communications 35941165 Nat Commun 2022 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/35941165
Phase separation drives aberrant chromatin looping and cancer development. Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH, Wang GG Nature 34163069 Nature 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34163069
Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment. Daugird TA, Shi Y, Holland KL, Rostamian H, Liu Z, Lavis LD, Rodriguez J, Strahl BD, Legant WR Nature communications 38755200 Nat Commun 2024 May 16 https://www.ncbi.nlm.nih.gov/pubmed/38755200
A series of spontaneously blinking dyes for super-resolution microscopy. Holland KL, Plutkis SE, Daugird TA, Sau A, Grimm JB, English BP, Zheng Q, Dave S, Rahman F, Xie L, Dong P, Tkachuk AN, Brown TA, Singer RH, Liu Z, Galbraith CG, Musser SM, Legant WR, Lavis LD bioRxiv : the preprint server for biology 38766149 bioRxiv 2024 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/38766149
Shared and redundant proteins coordinate signal cross-talk between MAPK pathways in yeast. Zhang S, Wang H, Sipko EL, Li S, Daugird TA, Legant WR, Dohlman HG Molecular biology of the cell 39083355 Mol Biol Cell 2024 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/39083355
u-track3D: Measuring, navigating, and validating dense particle trajectories in three dimensions. Roudot P, Legant WR, Zou Q, Dean KM, Isogai T, Welf ES, David AF, Gerlich DW, Fiolka R, Betzig E, Danuser G Cell reports methods 38042149 Cell Rep Methods 2023 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/38042149
Smart lattice light-sheet microscopy for imaging rare and complex cellular events. Shi Y, Tabet JS, Milkie DE, Daugird TA, Yang CQ, Ritter AT, Giovannucci A, Legant WR Nature methods 38167656 Nat Methods 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38167656
Mapping the nuclear landscape with multiplexed super-resolution fluorescence microscopy. Rahman F, Augoustides V, Tyler E, Daugird TA, Arthur C, Legant WR bioRxiv : the preprint server for biology 39211261 bioRxiv 2024 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/39211261
Mapping the nuclear landscape with multiplexed super-resolution fluorescence microscopy. Rahman F, Augoustides V, Tyler E, Daugird TA, Arthur C, Legant WR Nature communications 40593784 Nat Commun 2025 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/40593784
Measurement of cellular traction forces during confined migration. Hockenberry MA, Ulmer AJ, Rapp JL, Truscott HH, Leibfarth FA, Bear JE, Legant WR Proceedings of the National Academy of Sciences of the United States of America 41289376 Proc Natl Acad Sci U S A 2025 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/41289376
Deep learning enables fast and dense single-molecule localization with high accuracy. Speiser A, Müller LR, Hoess P, Matti U, Obara CJ, Legant WR, Kreshuk A, Macke JH, Ries J, Turaga SC Nature methods 34480155 Nat Methods 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34480155
Posterior approach to correct for focal plane offsets in lattice light-sheet structured illumination microscopy. Shi Y, Daugird TA, Legant WR Journal of biomedical optics 39086928 J Biomed Opt 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/39086928
Cell dynamics revealed by microscopy advances. Hockenberry MA, Daugird TA, Legant WR Current opinion in cell biology 39159598 Curr Opin Cell Biol 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39159598
A multi-functional microfluidic device compatible with widefield and light sheet microscopy. Moore RP, O'Shaughnessy EC, Shi Y, Nogueira AT, Heath KM, Hahn KM, Legant WR Lab on a chip 34859808 Lab Chip 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34859808
Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Rao C, Coyte KZ, Bainter W, Geha RS, Martin CR, Rakoff-Nahoum S Nature 33627867 Nature 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33627867
The gut microbiome. Kuziel GA, Rakoff-Nahoum S Current biology : CB 35349808 Curr Biol 2022 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/35349808
Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Park SY, Rao C, Coyte KZ, Kuziel GA, Zhang Y, Huang W, Franzosa EA, Weng JK, Huttenhower C, Rakoff-Nahoum S Cell 35120663 Cell 2022 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/35120663
Ecological rules for the assembly of microbiome communities. Coyte KZ, Rao C, Rakoff-Nahoum S, Foster KR PLoS biology 33606675 PLoS Biol 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33606675
RELMβ sets the threshold for microbiome-dependent oral tolerance. Stephen-Victor E, Kuziel GA, Martinez-Blanco M, Jugder BE, Benamar M, Wang Z, Chen Q, Lozano GL, Abdel-Gadir A, Cui Y, Fong J, Saint-Denis E, Chang I, Nadeau KC, Phipatanakul W, Zhang A, Farraj FA, Holder-Niles F, Zeve D, Breault DT, Schmitz-Abe K, Rachid R, Crestani E, Rakoff-Nahoum S, Chatila TA Nature 39843735 Nature 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39843735
A glycan atlas of the mammalian intestine through ontogeny and inflammation. Siegel SJ, Pomerantz D, Heimburg-Molinaro J, Danish Mahmood S, Korzenik JR, Cummings RD, Rakoff-Nahoum S bioRxiv : the preprint server for biology 40661523 bioRxiv 2025 May 28 https://www.ncbi.nlm.nih.gov/pubmed/40661523
Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens. Wu SC, Kamili NA, Dias-Baruffi M, Josephson CD, Rathgeber MF, Yeung MY, Lane WJ, Wang J, Jan HM, Rakoff-Nahoum S, Cummings RD, Stowell SR, Arthur CM iScience 35754739 iScience 2022 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/35754739
Bacterial amylases enable glycogen degradation by the vaginal microbiome. Jenkins DJ, Woolston BM, Hood-Pishchany MI, Pelayo P, Konopaski AN, Quinn Peters M, France MT, Ravel J, Mitchell CM, Rakoff-Nahoum S, Whidbey C, Balskus EP Nature microbiology 37563289 Nat Microbiol 2023 Sep https://www.ncbi.nlm.nih.gov/pubmed/37563289
Galectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain. Jan HM, Wu SC, Stowell CJ, Vallecillo-Zúniga ML, Paul A, Patel KR, Muthusamy S, Lin HY, Ayona D, Jajosky RP, Varadkar SP, Nakahara H, Chan R, Bhave D, Lane WJ, Yeung MY, Hollenhorst MA, Rakoff-Nahoum S, Cummings RD, Arthur CM, Stowell SR Molecular & cellular proteomics : MCP 38490531 Mol Cell Proteomics 2024 May https://www.ncbi.nlm.nih.gov/pubmed/38490531
Functional diversification of dietary plant small molecules by the gut microbiome. Kuziel GA, Lozano GL, Simian C, Li L, Manion J, Stephen-Victor E, Chatila T, Dong M, Weng JK, Rakoff-Nahoum S Cell 40056901 Cell 2025 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/40056901
Veni, vidi, vici: the success of wtf meiotic drivers in fission yeast. López Hernández JF, Zanders SE Yeast (Chichester, England) 29322557 Yeast 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29322557
Gene conversion generates evolutionary novelty that fuels genetic conflicts. Daugherty MD, Zanders SE Current opinion in genetics & development 31466040 Curr Opin Genet Dev 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31466040
Molecular Mechanisms and Evolutionary Consequences of Spore Killers in Ascomycetes. Zanders S, Johannesson H Microbiology and molecular biology reviews : MMBR 34756084 Microbiol Mol Biol Rev 2021 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/34756084
Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans. Billmyre RB, Craig CJ, Lyon JW, Reichardt C, Kuhn AM, Eickbush MT, Zanders SE PLoS biology 40402997 PLoS Biol 2025 May https://www.ncbi.nlm.nih.gov/pubmed/40402997
Functional constraints of wtf killer meiotic drivers. Nidamangala Srinivasa A, Campbell S, Venkatesan S, Nuckolls NL, Lange JJ, Halfmann R, Zanders SE PLoS genetics 39965018 PLoS Genet 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39965018
wtf genes are prolific dual poison-antidote meiotic drivers. Nuckolls NL, Bravo Núñez MA, Eickbush MT, Young JM, Lange JJ, Yu JS, Smith GR, Jaspersen SL, Malik HS, Zanders SE eLife 28631612 Elife 2017 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/28631612
Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast. Billmyre RB, Eickbush MT, Craig CJ, Lange JJ, Wood C, Helston RM, Zanders SE PLoS genetics 36301993 PLoS Genet 2022 Oct https://www.ncbi.nlm.nih.gov/pubmed/36301993
Meiotic drive. Srinivasa AN, Zanders SE Current biology : CB 32516606 Curr Biol 2020 Jun 8 https://www.ncbi.nlm.nih.gov/pubmed/32516606
Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency. Bravo Núñez MA, Sabbarini IM, Eickbush MT, Liang Y, Lange JJ, Kent AM, Zanders SE PLoS genetics 32032353 PLoS Genet 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/32032353
S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive. Nuckolls NL, Nidamangala Srinivasa A, Mok AC, Helston RM, Bravo Núñez MA, Lange JJ, Gallagher TJ, Seidel CW, Zanders SE PLoS genetics 36477651 PLoS Genet 2022 Dec https://www.ncbi.nlm.nih.gov/pubmed/36477651
Fertility Costs of Meiotic Drivers. Zanders SE, Unckless RL Current biology : CB 31163165 Curr Biol 2019 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/31163165
A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver's antidote. Bravo Núñez MA, Lange JJ, Zanders SE PLoS genetics 30475921 PLoS Genet 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30475921
Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family. Eickbush MT, Young JM, Zanders SE Molecular biology and evolution 30991417 Mol Biol Evol 2019 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/30991417
Chromosome segregation: human female meiosis breaks all the rules. Zanders SE, Malik HS Current biology : CB 26241139 Curr Biol 2015 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/26241139
The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death. Nuckolls NL, Mok AC, Lange JJ, Yi K, Kandola TS, Hunn AM, McCroskey S, Snyder JL, Bravo Núñez MA, McClain M, McKinney SA, Wood C, Halfmann R, Zanders SE eLife 33108274 Elife 2020 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/33108274
Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe. López Hernández JF, Helston RM, Lange JJ, Billmyre RB, Schaffner SH, Eickbush MT, McCroskey S, Zanders SE eLife 34895466 Elife 2021 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/34895466
The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years. De Carvalho M, Jia GS, Nidamangala Srinivasa A, Billmyre RB, Xu YH, Lange JJ, Sabbarini IM, Du LL, Zanders SE eLife 36227631 Elife 2022 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/36227631
Saturation transposon mutagenesis enables genome-wide identification of genes required for growth and fluconazole resistance in the human fungal pathogen Cryptococcus neoformans. Billmyre RB, Craig CJ, Lyon J, Reichardt C, Eickbush MT, Zanders SE bioRxiv : the preprint server for biology 39131341 bioRxiv 2024 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/39131341
What can we learn from selfish loci that break Mendel's law? Zanders SE PLoS biology 35853012 PLoS Biol 2022 Jul https://www.ncbi.nlm.nih.gov/pubmed/35853012
Modeling the evolution of Schizosaccharomyces pombe populations with multiple killer meiotic drivers. López Hernández JF, Rubinstein BY, Unckless RL, Zanders SE G3 (Bethesda, Md.) 38938172 G3 (Bethesda) 2024 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/38938172
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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response. Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S Nature cell biology 37857833 Nat Cell Biol 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37857833
Functionalizing DNA nanostructures for therapeutic applications. Henry SJW, Stephanopoulos N Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 34008347 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34008347
Coarse-Grained Simulations for the Characterization and Optimization of Hybrid Protein-DNA Nanostructures. Narayanan RP, Procyk J, Nandi P, Prasad A, Xu Y, Poppleton E, Williams D, Zhang F, Yan H, Chiu PL, Stephanopoulos N, Šulc P ACS nano 35980981 ACS Nano 2022 Sep 27 https://www.ncbi.nlm.nih.gov/pubmed/35980981
Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer. Reyes L, Naser L, Weiner WS, Thifault D, Stahl E, McCreary L, Nott R, Quick C, Buchberger A, Alvarado C, Rivera A, Miller JA, Khatiwala R, Cherry BR, Nelson R, Martin-Garcia JM, Stephanopoulos N, Fromme R, Fromme P, Cance W, Marlowe T Nature communications 40021642 Nat Commun 2025 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/40021642
Geometrically constrained cytoskeletal reorganisation modulates DNA nanostructures uptake. Elblová P, Andělová H, Lunova M, Anthi J, Henry SJW, Tu X, Dejneka A, Jirsa M, Stephanopoulos N, Lunov O Journal of materials chemistry. B 39835937 J Mater Chem B 2025 Feb 12 https://www.ncbi.nlm.nih.gov/pubmed/39835937
Using dynamic biomaterials to study the temporal role of bioactive peptides during osteogenesis. Fumasi FM, MacCulloch T, Bernal-Chanchavac J, Stephanopoulos N, Holloway JL Biomaterials advances 38096646 Biomater Adv 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/38096646
CytoDirect: A Nucleic Acid Nanodevice for Specific and Efficient Delivery of Functional Payloads to the Cytoplasm. Yu L, Xu Y, Al-Amin M, Jiang S, Sample M, Prasad A, Stephanopoulos N, Šulc P, Yan H Journal of the American Chemical Society 38055928 J Am Chem Soc 2023 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/38055928
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Nanoscale Structures and Materials from the Self-assembly of Polypeptides and DNA. Bernal-Chanchavac J, Al-Amin M, Stephanopoulos N Current topics in medicinal chemistry 34911426 Curr Top Med Chem 2022 https://www.ncbi.nlm.nih.gov/pubmed/34911426
Calcium-triggered DNA-mediated membrane fusion in synthetic cells. Hsu YY, Chen SJ, Bernal-Chanchavac J, Sharma B, Moghimianavval H, Stephanopoulos N, Liu AP Chemical communications (Cambridge, England) 37365952 Chem Commun (Camb) 2023 Jul 13 https://www.ncbi.nlm.nih.gov/pubmed/37365952
Construction and reconfiguration of dynamic DNA origami assemblies with coiled-coil patches and patterns. Teng T, Bernal-Chanchavac J, Stephanopoulos N, Castro CE bioRxiv : the preprint server for biology 37790447 bioRxiv 2023 Sep 24 https://www.ncbi.nlm.nih.gov/pubmed/37790447
Site-specific arrangement and structure determination of minor groove binding molecules in self-assembled three-dimensional DNA crystals. Simmons CR, Buchberger A, Henry SJW, Novacek A, Fahmi NE, MacCulloch T, Stephanopoulos N, Yan H bioRxiv : the preprint server for biology 37873139 bioRxiv 2023 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/37873139
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Protein Corona Inhibits Endosomal Escape of Functionalized DNA Nanostructures in Living Cells. Smolková B, MacCulloch T, Rockwood TF, Liu M, Henry SJW, Frtús A, Uzhytchak M, Lunova M, Hof M, Jurkiewicz P, Dejneka A, Stephanopoulos N, Lunov O ACS applied materials & interfaces 34569777 ACS Appl Mater Interfaces 2021 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/34569777
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DNA-Nanostructure-Guided Assembly of Proteins into Programmable Shapes. Lu Q, Xu Y, Poppleton E, Zhou K, Sulc P, Stephanopoulos N, Ke Y Nano letters 38278134 Nano Lett 2024 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/38278134
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Bioactive Fibronectin-III(10)-DNA Origami Nanofibers Promote Cell Adhesion and Spreading. Buchberger A, Riker K, Bernal-Chanchavac J, Narayanan RP, Simmons CR, Fahmi NE, Freeman R, Stephanopoulos N ACS applied bio materials 36108278 ACS Appl Bio Mater 2022 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/36108278
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High-Affinity Host-Guest Recognition for Efficient Assembly and Enzymatic Responsiveness of DNA Nanostructures. Narayanan RP, Prasad A, Buchberger A, Zou L, Bernal-Chanchavac J, MacCulloch T, Fahmi NE, Yan H, Zhang F, Webber MJ, Stephanopoulos N Small (Weinheim an der Bergstrasse, Germany) 37849034 Small 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/37849034
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A Neuropeptide Signaling Network That Regulates Developmental Timing and Systemic Growth in Drosophila. Ohhara Y, Blick M, Park D, Yoon SE, Kim YJ, Pankratz MJ, O'Connor MB, Yamanaka N The Journal of comparative neurology 39415613 J Comp Neurol 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/39415613
Functional characterization of eicosanoid signaling in Drosophila development. Fujinaga D, Nolan C, Yamanaka N bioRxiv : the preprint server for biology 39868285 bioRxiv 2025 Mar 18 https://www.ncbi.nlm.nih.gov/pubmed/39868285
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Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins. Leander M, Liu Z, Cui Q, Raman S eLife 36226916 Elife 2022 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/36226916
Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens. Miller ST, Macdonald CB, Raman S Cell chemical biology 40168989 Cell Chem Biol 2025 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/40168989
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors. Meger AT, Spence MA, Sandhu M, Matthews D, Chen J, Jackson CJ, Raman S Cell systems 38537640 Cell Syst 2024 Apr 17 https://www.ncbi.nlm.nih.gov/pubmed/38537640
De novo design of programmable inducible promoters. Liu X, Gupta STP, Bhimsaria D, Reed JL, Rodríguez-Martínez JA, Ansari AZ, Raman S Nucleic acids research 31552424 Nucleic Acids Res 2019 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/31552424
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Discovering chromatin dysregulation induced by protein-coding perturbations at scale. Frenkel M, Hujoel MLA, Morris Z, Raman S bioRxiv : the preprint server for biology 37781603 bioRxiv 2023 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/37781603
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Computation-guided redesign of promoter specificity of a bacterial RNA polymerase. Liu X, Meger AT, Gillis T, O'Mara Schwartz J, Sah B, Landick R, Raman S bioRxiv : the preprint server for biology 40667222 bioRxiv 2025 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/40667222
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Single-molecule displacement mapping unveils nanoscale heterogeneities in intracellular diffusivity. Xiang L, Chen K, Yan R, Li W, Xu K Nature methods 32203387 Nat Methods 2020 May https://www.ncbi.nlm.nih.gov/pubmed/32203387
Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing. Chen K, Yan R, Xiang L, Xu K Light, science & applications 33963178 Light Sci Appl 2021 May 8 https://www.ncbi.nlm.nih.gov/pubmed/33963178
Single-Molecule Spectroscopy and Super-Resolution Mapping of Physicochemical Parameters in Living Cells. Steves MA, He C, Xu K Annual review of physical chemistry 38360526 Annu Rev Phys Chem 2024 Jun https://www.ncbi.nlm.nih.gov/pubmed/38360526
Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells. Jin M, Shirazinejad C, Wang B, Yan A, Schöneberg J, Upadhyayula S, Xu K, Drubin DG Nature communications 35732852 Nat Commun 2022 Jun 22 https://www.ncbi.nlm.nih.gov/pubmed/35732852
The endoplasmic reticulum adopts two distinct tubule forms. Wang B, Zhao Z, Xiong M, Yan R, Xu K Proceedings of the National Academy of Sciences of the United States of America 35471903 Proc Natl Acad Sci U S A 2022 May 3 https://www.ncbi.nlm.nih.gov/pubmed/35471903
Probing Nanoscale Diffusional Heterogeneities in Cellular Membranes through Multidimensional Single-Molecule and Super-Resolution Microscopy. Yan R, Chen K, Xu K Journal of the American Chemical Society 33084318 J Am Chem Soc 2020 Nov 4 https://www.ncbi.nlm.nih.gov/pubmed/33084318
Displacement Statistics of Unhindered Single Molecules Show no Enhanced Diffusion in Enzymatic Reactions. Choi AA, Park HH, Chen K, Yan R, Li W, Xu K Journal of the American Chemical Society 35258969 J Am Chem Soc 2022 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/35258969
SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport. Yan R, Chen K, Wang B, Xu K Developmental cell 35051356 Dev Cell 2022 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/35051356
Super-multiplexing excitation spectral microscopy with multiple fluorescence bands. Chen K, Li W, Xu K Biomedical optics express 36733753 Biomed Opt Express 2022 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/36733753
Single-Molecule Displacement Mapping Unveils Sign-Asymmetric Protein Charge Effects on Intraorganellar Diffusion. Xiang L, Yan R, Chen K, Li W, Xu K Nano letters 36802676 Nano Lett 2023 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/36802676
Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Truong ME, Bilekova S, Choksi SP, Li W, Bugaj LJ, Xu K, Reiter JF Cell 33932338 Cell 2021 May 27 https://www.ncbi.nlm.nih.gov/pubmed/33932338
Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates. He C, Wu CY, Li W, Xu K bioRxiv : the preprint server for biology 37503034 bioRxiv 2023 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/37503034
Multidimensional Super-Resolution Microscopy Unveils Nanoscale Surface Aggregates in the Aging of FUS Condensates. He C, Wu CY, Li W, Xu K Journal of the American Chemical Society 37782826 J Am Chem Soc 2023 Nov 8 https://www.ncbi.nlm.nih.gov/pubmed/37782826
Single-Molecule Displacement Mapping Indicates Unhindered Intracellular Diffusion of Small (≲1 kDa) Solutes. Choi AA, Xiang L, Li W, Xu K Journal of the American Chemical Society 37027457 J Am Chem Soc 2023 Apr 7 https://www.ncbi.nlm.nih.gov/pubmed/37027457
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M Nature neuroscience 34031600 Nat Neurosci 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/34031600
Single Molecules Are Your Quanta: A Bottom-Up Approach toward Multidimensional Super-resolution Microscopy. Xiang L, Chen K, Xu K ACS nano 34304562 ACS Nano 2021 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/34304562
Graphene-Enabled, Spatially Controlled Electroporation of Adherent Cells for Live-Cell Super-resolution Microscopy. Moon S, Li W, Hauser M, Xu K ACS nano 32282180 ACS Nano 2020 May 26 https://www.ncbi.nlm.nih.gov/pubmed/32282180
Expanding the Scope of Palladium-Catalyzed B - N Cross-Coupling Chemistry in Carboranes. Mu X, Hopp M, Dziedzic RM, Waddington MA, Rheingold AL, Sletten EM, Axtell JC, Spokoyny AM Organometallics 34012188 Organometallics 2020 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/34012188
Carboranes without Cage Carbons: closo-Dodecaborate Mimics of Neutral closo-Carboranes. Ready AD, Tej Raviprolu V, Kerr TA, Treacy JW, Matsumoto ML, Hammer PE, Sletten EM, Houk KN, Spokoyny AM Journal of the American Chemical Society 40643954 J Am Chem Soc 2025 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/40643954
Bioorthogonal chemistry: Bridging chemistry, biology, and medicine. Hartung KM, Sletten EM Chem 39006002 Chem 2023 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/39006002
Arene-Perfluoroarene Interactions in Solution. Lee GY, Hu E, Rheingold AL, Houk KN, Sletten EM The Journal of organic chemistry 34077211 J Org Chem 2021 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/34077211
Cell-surface Labeling via Bioorthogonal Host-Guest Chemistry. Kataki-Anastasakou A, Hernandez S, Sletten EM ACS chemical biology 34669367 ACS Chem Biol 2021 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/34669367
A Fluorescent Unnatural Mannosamine Derivative with Enhanced Emission Upon Complexation with Cucurbit[7]uril. Kataki-Anastasakou A, Jia S, Axtell JC, Sletten EM Israel journal of chemistry 37636996 Isr J Chem 2023 Feb https://www.ncbi.nlm.nih.gov/pubmed/37636996
Achieving Olympicene Functionalization Three Ways. Hartung KM, Sletten EM The Journal of organic chemistry 39698889 J Org Chem 2025 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/39698889
Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and On-Demand Removal. Kataki-Anastasakou A, Axtell JC, Hernandez S, Dziedzic RM, Balaich GJ, Rheingold AL, Spokoyny AM, Sletten EM Journal of the American Chemical Society 33253553 J Am Chem Soc 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33253553
Optothermophoretic Manipulation of Colloidal Particles in Nonionic Liquids. Peng X, Lin L, Hill EH, Kunal P, Humphrey SM, Zheng Y The journal of physical chemistry. C, Nanomaterials and interfaces 30766650 J Phys Chem C Nanomater Interfaces 2018 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/30766650
Nanoradiator-Mediated Deterministic Opto-Thermoelectric Manipulation. Liu Y, Lin L, Bangalore Rajeeva B, Jarrett JW, Li X, Peng X, Kollipara P, Yao K, Akinwande D, Dunn AK, Zheng Y ACS nano 30226980 ACS Nano 2018 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/30226980
Thermo-Electro-Mechanics at Individual Particles in Complex Colloidal Systems. Kollipara PS, Lin L, Zheng Y The journal of physical chemistry. C, Nanomaterials and interfaces 32913480 J Phys Chem C Nanomater Interfaces 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/32913480
Enhancing Surface Capture and Sensing of Proteins with Low-Power Optothermal Bubbles in a Biphasic Liquid. Kim Y, Ding H, Zheng Y Nano letters 32667815 Nano Lett 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/32667815
Decoding Optical Data with Machine Learning. Fang J, Swain A, Unni R, Zheng Y Laser & photonics reviews 34539925 Laser Photon Rev 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/34539925
Room-Temperature Observation of Near-Intrinsic Exciton Linewidth in Monolayer WS(2). Fang J, Yao K, Zhang T, Wang M, Jiang T, Huang S, Korgel BA, Terrones M, Alù A, Zheng Y Advanced materials (Deerfield Beach, Fla.) 35170105 Adv Mater 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35170105
Opto-refrigerative tweezers. Li J, Chen Z, Liu Y, Kollipara PS, Feng Y, Zhang Z, Zheng Y Science advances 34172454 Sci Adv 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34172454
Atomistic modeling and rational design of optothermal tweezers for targeted applications. Ding H, Kollipara PS, Lin L, Zheng Y Nano research 35475031 Nano Res 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/35475031
Optical manipulation and assembly of micro/nanoscale objects on solid substrates. Li J, Alfares A, Zheng Y iScience 35313687 iScience 2022 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/35313687
Tunable Strong Coupling in Transition Metal Dichalcogenide Nanowires. Li J, Yao K, Huang Y, Fang J, Kollipara PS, Fan DE, Zheng Y Advanced materials (Deerfield Beach, Fla.) 35793202 Adv Mater 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35793202
Deep Convolutional Mixture Density Network for Inverse Design of Layered Photonic Structures. Unni R, Yao K, Zheng Y ACS photonics 38031541 ACS Photonics 2020 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/38031541
Optical Patterning of Two-Dimensional Materials. Kollipara PS, Li J, Zheng Y Research (Washington, D.C.) 32043085 Research (Wash D C) 2020 https://www.ncbi.nlm.nih.gov/pubmed/32043085
Optical nanomanipulation on solid substrates via optothermally-gated photon nudging. Li J, Liu Y, Lin L, Wang M, Jiang T, Guo J, Ding H, Kollipara PS, Inoue Y, Fan D, Korgel BA, Zheng Y Nature communications 31831746 Nat Commun 2019 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/31831746
Sensitivity-Enhancing Strategies in Optical Biosensing. Kim Y, Gonzales J, Zheng Y Small (Weinheim an der Bergstrasse, Germany) 33369864 Small 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33369864
Tunable Chiral Optics in All-Solid-Phase Reconfigurable Dielectric Nanostructures. Li J, Wang M, Wu Z, Li H, Hu G, Jiang T, Guo J, Liu Y, Yao K, Chen Z, Fang J, Fan D, Korgel BA, Alù A, Zheng Y Nano letters 33372805 Nano Lett 2021 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/33372805
Intelligent nanophotonics: merging photonics and artificial intelligence at the nanoscale. Yao K, Unni R, Zheng Y Nanophotonics (Berlin, Germany) 34290952 Nanophotonics 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/34290952
Opto-thermophoretic fiber tweezers. Kotnala A, Zheng Y Nanophotonics (Berlin, Germany) 34290953 Nanophotonics 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/34290953
Directional light emission by electric and magnetic dipoles near a nanosphere: an analytical approach based on the generalized Mie theory. Yao K, Zheng Y Optics letters 33449012 Opt Lett 2021 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/33449012
All-optical reconfigurable chiral meta-molecules. Lin L, Lepeshov S, Krasnok A, Jiang T, Peng X, Korgel BA, Alù A, Zheng Y Materials today (Kidlington, England) 31777449 Mater Today (Kidlington) 2019 May https://www.ncbi.nlm.nih.gov/pubmed/31777449
Opto-Thermophoretic Manipulation and Construction of Colloidal Superstructures in Photocurable Hydrogels. Peng X, Li J, Lin L, Liu Y, Zheng Y ACS applied nano materials 31106296 ACS Appl Nano Mater 2018 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/31106296
Digital manufacturing of advanced materials: challenges and perspective. Lin L, Kollipara PS, Zheng Y Materials today (Kidlington, England) 32831619 Mater Today (Kidlington) 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/32831619
Digital Assembly of Colloidal Particles for Nanoscale Manufacturing. Kotnala A, Zheng Y Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems 33041521 Part Part Syst Charact 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/33041521
Opto-thermoelectric nanotweezers. Lin L, Wang M, Peng X, Lissek EN, Mao Z, Scarabelli L, Adkins E, Coskun S, Unalan HE, Korgel BA, Liz-Marzán LM, Florin EL, Zheng Y Nature photonics 29785202 Nat Photonics 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29785202
A mixture-density-based tandem optimization network for on-demand inverse design of thin-film high reflectors. Unni R, Yao K, Han X, Zhou M, Zheng Y Nanophotonics (Berlin, Germany) 36425324 Nanophotonics 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/36425324
Plasmonic Nanotweezers and Nanosensors for Point-of-Care Applications. Peng X, Kotnala A, Rajeeva BB, Wang M, Yao K, Bhatt N, Penley D, Zheng Y Advanced optical materials 34434691 Adv Opt Mater 2021 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/34434691
Universal optothermal micro/nanoscale rotors. Ding H, Kollipara PS, Kim Y, Kotnala A, Li J, Chen Z, Zheng Y Science advances 35704582 Sci Adv 2022 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/35704582
Controlling the polarization of chiral dipolar emission with a spherical dielectric nanoantenna. Yao K, Zheng Y The Journal of chemical physics 34911301 J Chem Phys 2021 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/34911301
Heat-Mediated Optical Manipulation. Chen Z, Li J, Zheng Y Chemical reviews 34797041 Chem Rev 2022 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/34797041
Programmable Multimodal Optothermal Manipulation of Synthetic Particles and Biological Cells. Ding H, Chen Z, Kollipara PS, Liu Y, Kim Y, Huang S, Zheng Y ACS nano 35816157 ACS Nano 2022 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/35816157
Optical Nanoprinting of Colloidal Particles and Functional Structures. Li J, Hill EH, Lin L, Zheng Y ACS nano 30875190 ACS Nano 2019 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/30875190
Optothermal Manipulations of Colloidal Particles and Living Cells. Lin L, Hill EH, Peng X, Zheng Y Accounts of chemical research 29799720 Acc Chem Res 2018 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/29799720
Broadband Forward Light Scattering by Architectural Design of Core-Shell Silicon Particles. De Marco ML, Jiang T, Fang J, Lacomme S, Zheng Y, Baron A, Korgel BA, Barois P, Drisko GL, Aymonier C Advanced functional materials 38031546 Adv Funct Mater 2021 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/38031546
Opto-Thermoelectric Tweezers: Principles and Applications. Pughazhendi A, Chen Z, Wu Z, Li J, Zheng Y Frontiers in physics 38031585 Front Phys 2020 https://www.ncbi.nlm.nih.gov/pubmed/38031585
Light-driven C-H activation mediated by 2D transition metal dichalcogenides. Li J, Zhang D, Guo Z, Jiang X, Larson JM, Zhu H, Zhang T, Gu Y, Blankenship B, Chen M, Wu Z, Huang S, Kostecki R, Minor AM, Grigoropoulos CP, Akinwande D, Terrones M, Redwing JM, Li H, Zheng Y Research square 38260621 Res Sq 2024 Jan 5 https://www.ncbi.nlm.nih.gov/pubmed/38260621
Label-Free Ultrasensitive Detection of Abnormal Chiral Metabolites in Diabetes. Liu Y, Wu Z, Kollipara PS, Montellano R, Sharma K, Zheng Y ACS nano 33760602 ACS Nano 2021 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/33760602
Liquid Optothermoelectrics: Fundamentals and Applications. Chen Z, Kollipara PS, Ding H, Pughazhendi A, Zheng Y Langmuir : the ACS journal of surfaces and colloids 33410698 Langmuir 2021 Feb 2 https://www.ncbi.nlm.nih.gov/pubmed/33410698
Opto-Thermophoretic Tweezers and Assembly. Li J, Lin L, Inoue Y, Zheng Y Journal of micro- and nano-manufacturing 35832388 J Micro Nanomanuf 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/35832388
Bubble-pen lithography: Fundamentals and applications: Nanoscience: Special Issue Dedicated to Professor Paul S. Weiss. Kollipara PS, Mahendra R, Li J, Zheng Y Aggregate (Hoboken, N.J.) 37441005 Aggregate (Hoboken) 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/37441005
Directional Modulation of Exciton Emission Using Single Dielectric Nanospheres. Fang J, Wang M, Yao K, Zhang T, Krasnok A, Jiang T, Choi J, Kahn E, Korgel BA, Terrones M, Li X, Alù A, Zheng Y Advanced materials (Deerfield Beach, Fla.) 33837615 Adv Mater 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33837615
Opto-thermoelectric speckle tweezers. Kotnala A, Kollipara PS, Zheng Y Nanophotonics (Berlin, Germany) 34290954 Nanophotonics 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/34290954
Optothermally Assembled Nanostructures. Li J, Zheng Y Accounts of materials research 34396151 Acc Mater Res 2021 May 28 https://www.ncbi.nlm.nih.gov/pubmed/34396151
Opto-Thermophoretic Attraction, Trapping, and Dynamic Manipulation of Lipid Vesicles. Hill EH, Li J, Lin L, Liu Y, Zheng Y Langmuir : the ACS journal of surfaces and colloids 30350700 Langmuir 2018 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/30350700
Overcoming Diffusion-Limited Trapping in Nanoaperture Tweezers Using Opto-Thermal-Induced Flow. Kotnala A, Kollipara PS, Li J, Zheng Y Nano letters 31834809 Nano Lett 2020 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/31834809
Light-driven single-cell rotational adhesion frequency assay. Liu Y, Ding H, Li J, Lou X, Yang M, Zheng Y eLight 35965781 eLight 2022 https://www.ncbi.nlm.nih.gov/pubmed/35965781
Light-driven C-H activation mediated by 2D transition metal dichalcogenides. Li J, Zhang D, Guo Z, Chen Z, Jiang X, Larson JM, Zhu H, Zhang T, Gu Y, Blankenship BW, Chen M, Wu Z, Huang S, Kostecki R, Minor AM, Grigoropoulos CP, Akinwande D, Terrones M, Redwing JM, Li H, Zheng Y Nature communications 38956055 Nat Commun 2024 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/38956055
Suppressing material loss in the visible and near-infrared range for functional nanophotonics using bandgap engineering. Wang M, Krasnok A, Lepeshov S, Hu G, Jiang T, Fang J, Korgel BA, Alù A, Zheng Y Nature communications 33028825 Nat Commun 2020 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/33028825
Opto-thermoelectric microswimmers. Peng X, Chen Z, Kollipara PS, Liu Y, Fang J, Lin L, Zheng Y Light, science & applications 32864116 Light Sci Appl 2020 https://www.ncbi.nlm.nih.gov/pubmed/32864116
Enhancing Single-Molecule Fluorescence Spectroscopy with Simple and Robust Hybrid Nanoapertures. Kotnala A, Ding H, Zheng Y ACS photonics 35445142 ACS Photonics 2021 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/35445142
Opto-Thermocapillary Nanomotors on Solid Substrates. Li J, Kollipara PS, Liu Y, Yao K, Liu Y, Zheng Y ACS nano 35594375 ACS Nano 2022 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/35594375
Investigating water/oil interfaces with opto-thermophoresis. Kim Y, Ding H, Zheng Y Nature communications 35768421 Nat Commun 2022 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/35768421
The shape of pleomorphic virions determines resistance to cell-entry pressure. Li T, Li Z, Deans EE, Mittler E, Liu M, Chandran K, Ivanovic T Nature microbiology 33737748 Nat Microbiol 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33737748
Hemagglutinin Stability Determines Influenza A Virus Susceptibility to a Broad-Spectrum Fusion Inhibitor Arbidol. Li Z, Li T, Liu M, Ivanovic T ACS infectious diseases 35819162 ACS Infect Dis 2022 Aug 12 https://www.ncbi.nlm.nih.gov/pubmed/35819162
Influenza A virus rapidly adapts particle shape to environmental pressures. Partlow EA, Jaeggi-Wong A, Planitzer SD, Berg N, Li Z, Ivanovic T Nature microbiology 39929974 Nat Microbiol 2025 Mar https://www.ncbi.nlm.nih.gov/pubmed/39929974
Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition. Bhattacharyya S, Duan J, Wang L, Li B, Bhakta M, Fernandez-Perez A, Hon GC, Munshi NV Scientific reports 30765799 Sci Rep 2019 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/30765799
Rational Reprogramming of Cellular States by Combinatorial Perturbation. Duan J, Li B, Bhakta M, Xie S, Zhou P, Munshi NV, Hon GC Cell reports 31216470 Cell Rep 2019 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/31216470
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. Hepler C, Shan B, Zhang Q, Henry GH, Shao M, Vishvanath L, Ghaben AL, Mobley AB, Strand D, Hon GC, Gupta RK eLife 30265241 Elife 2018 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/30265241
Computational identification of clonal cells in single-cell CRISPR screens. Wang Y, Xie S, Armendariz D, Hon GC BMC genomics 35168568 BMC Genomics 2022 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/35168568
Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules. Xie S, Armendariz D, Zhou P, Duan J, Hon GC Cell reports 31775028 Cell Rep 2019 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/31775028
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. Henry GH, Malewska A, Joseph DB, Malladi VS, Lee J, Torrealba J, Mauck RJ, Gahan JC, Raj GV, Roehrborn CG, Hon GC, MacConmara MP, Reese JC, Hutchinson RC, Vezina CM, Strand DW Cell reports 30566875 Cell Rep 2018 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/30566875
Experimental and Computational Approaches for Single-Cell Enhancer Perturbation Assay. Xie S, Hon GC Methods in molecular biology (Clifton, N.J.) 30758829 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/30758829
CHD-associated enhancers shape human cardiomyocyte lineage commitment. Armendariz DA, Goetsch SC, Sundarrajan A, Sivakumar S, Wang Y, Xie S, Munshi NV, Hon GC eLife 37096669 Elife 2023 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/37096669
Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption. Cooley A, Madhukaran S, Stroebele E, Colon Caraballo M, Wang L, Akgul Y, Hon GC, Mahendroo M iScience 36718364 iScience 2023 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/36718364
A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum. Zhang Y, Li B, Cananzi S, Han C, Wang LL, Zou Y, Fu YX, Hon GC, Zhang CL Proceedings of the National Academy of Sciences of the United States of America 35254903 Proc Natl Acad Sci U S A 2022 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/35254903
Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. Wang Y, Armendariz D, Wang L, Zhao H, Xie S, Hon GC bioRxiv : the preprint server for biology 38045327 bioRxiv 2023 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/38045327
Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells. Sivakumar S, Wang Y, Goetsch SC, Pandit V, Wang L, Zhao H, Sundarrajan A, Armendariz D, Takeuchi C, Nzima M, Chen WC, Dederich AE, El Hayek L, Gao T, Ghazawi R, Gogate A, Kaur K, Kim HB, McCoy MK, Niederstrasser H, Oura S, Pinzon-Arteaga CA, Sanghvi M, Schmitz DA, Yu L, Zhang Y, Zhou Q, Kraus WL, Xu L, Wu J, Posner BA, Chahrour MH, Hon GC, Munshi NV bioRxiv : the preprint server for biology 39896670 bioRxiv 2025 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/39896670
Accurate Classification of Cardiomyopathy Diagnosis by Chromatin Accessibility. Bhattacharyya S, Duan J, Vela RJ, Bhakta M, Bajona P, Mammen PPA, Hon GC, Munshi NV Circulation 36095061 Circulation 2022 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/36095061
Breaking enhancers to gain insights into developmental defects. Armendariz DA, Sundarrajan A, Hon GC eLife 37497775 Elife 2023 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/37497775
FBA: feature barcoding analysis for single cell RNA-Seq. Duan J, Hon GC Bioinformatics (Oxford, England) 33999185 Bioinformatics 2021 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/33999185
Single-Cell Genomics: Catalyst for Cell Fate Engineering. Li B, Hon GC Frontiers in bioengineering and biotechnology 34733831 Front Bioeng Biotechnol 2021 https://www.ncbi.nlm.nih.gov/pubmed/34733831
SCINA: A Semi-Supervised Subtyping Algorithm of Single Cells and Bulk Samples. Zhang Z, Luo D, Zhong X, Choi JH, Ma Y, Wang S, Mahrt E, Guo W, Stawiski EW, Modrusan Z, Seshagiri S, Kapur P, Hon GC, Brugarolas J, Wang T Genes 31336988 Genes (Basel) 2019 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/31336988
Frequent sgRNA-barcode recombination in single-cell perturbation assays. Xie S, Cooley A, Armendariz D, Zhou P, Hon GC PloS one 29874289 PLoS One 2018 https://www.ncbi.nlm.nih.gov/pubmed/29874289
Rapid local adaptation linked with phenotypic plasticity. Sun SJ, Catherall AM, Pascoal S, Jarrett BJM, Miller SE, Sheehan MJ, Kilner RM Evolution letters 32774883 Evol Lett 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32774883
Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps. Uy FMK, Jernigan CM, Zaba NC, Mehrotra E, Miller SE, Sheehan MJ PLoS genetics 34478434 PLoS Genet 2021 Sep https://www.ncbi.nlm.nih.gov/pubmed/34478434
The promises and challenges of archiving insect behavior and natural history in a changing world. Sheehan MJ, Miller SE Current opinion in insect science 33857642 Curr Opin Insect Sci 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/33857642
Sex differences in deleterious genetic variants in a haplodiploid social insect. Miller SE, Sheehan MJ Molecular ecology 37350360 Mol Ecol 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37350360
Evidence for a selective link between cooperation and individual recognition. Tumulty JP, Miller SE, Van Belleghem SM, Weller HI, Jernigan CM, Vincent S, Staudenraus RJ, Legan AW, Polnaszek TJ, Uy FMK, Walton A, Sheehan MJ Current biology : CB 38065097 Curr Biol 2023 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/38065097
Fine-Scale Population Structure but Limited Genetic Differentiation in a Cooperatively Breeding Paper Wasp. Bluher SE, Miller SE, Sheehan MJ Genome biology and evolution 32271866 Genome Biol Evol 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32271866
Evolutionary dynamics of recent selection on cognitive abilities. Miller SE, Legan AW, Henshaw MT, Ostevik KL, Samuk K, Uy FMK, Sheehan MJ Proceedings of the National Academy of Sciences of the United States of America 31980529 Proc Natl Acad Sci U S A 2020 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/31980529
Hormonal modulation of reproduction in Polistes fuscatus social wasps: Dual functions in both ovary development and sexual receptivity. Walton A, Tumulty JP, Toth AL, Sheehan MJ Journal of insect physiology 31705844 J Insect Physiol 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31705844
Age and social experience induced plasticity across brain regions of the paper wasp Polistes fuscatus. Jernigan CM, Zaba NC, Sheehan MJ Biology letters 33849349 Biol Lett 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33849349
WASPnest: a worldwide assessment of social Polistine nesting behavior. Miller SE, Bluher SE, Bell E, Cini A, Silva RCD, de Souza AR, Gandia KM, Jandt J, Loope K, Prato A, Pruitt JN, Rankin D, Rankin E, Southon RJ, Uy FMK, Weiner S, Wright CM, Downing H, Gadagkar R, Cristina Lorenzi M, Rusina L, Sumner S, Tibbetts EA, Toth A, Sheehan MJ Ecology 29999519 Ecology 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29999519
Evolutionarily stable investments in recognition systems explain patterns of discrimination failure and success. Sheehan MJ, Reeve HK Philosophical transactions of the Royal Society of London. Series B, Biological sciences 32420853 Philos Trans R Soc Lond B Biol Sci 2020 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/32420853
Coevolution of cognitive abilities and identity signals in individual recognition systems. Miller SE, Sheehan MJ, Reeve HK Philosophical transactions of the Royal Society of London. Series B, Biological sciences 32420843 Philos Trans R Soc Lond B Biol Sci 2020 Jul 6 https://www.ncbi.nlm.nih.gov/pubmed/32420843
Color is necessary for face discrimination in the Northern paper wasp, Polistes fuscatus. Jernigan CM, Stafstrom JA, Zaba NC, Vogt CC, Sheehan MJ Animal cognition 36245014 Anim Cogn 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36245014
Expansion and Accelerated Evolution of 9-Exon Odorant Receptors in Polistes Paper Wasps. Legan AW, Jernigan CM, Miller SE, Fuchs MF, Sheehan MJ Molecular biology and evolution 34151983 Mol Biol Evol 2021 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/34151983
Animal Behavior: Socially Distanced Wasps Learn About Rivals. Sheehan MJ, Goldberg J Current biology : CB 32750347 Curr Biol 2020 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/32750347
Distinct evolutionary trajectories of V1R clades across mouse species. Miller CH, Campbell P, Sheehan MJ BMC evolutionary biology 32770934 BMC Evol Biol 2020 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/32770934
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A Concise, Modular Antibody-Oligonucleotide Conjugation Strategy Based on Disuccinimidyl Ester Activation Chemistry. Li G, Moellering RE Chembiochem : a European journal of chemical biology 30767357 Chembiochem 2019 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/30767357
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Family-Wide Photoproximity Profiling of Integrin Protein Social Networks in Cancer. Carlos AJ, Yang D, Thomas DM, Huang S, Harter KI, Moellering RE bioRxiv : the preprint server for biology 39345550 bioRxiv 2024 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/39345550
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A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE Nature 30323285 Nature 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30323285
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Rapid, quantitative determination of aggregation and particle formation for antibody drug conjugate therapeutics with label-free Raman spectroscopy. Zhang C, Springall JS, Wang X, Barman I Analytica chimica acta 31446951 Anal Chim Acta 2019 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/31446951
Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples. Pandey R, Singh SP, Zhang C, Horowitz GL, Lue N, Galindo L, Dasari RR, Barman I Journal of biophotonics 29726123 J Biophotonics 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29726123
Identification and Staging of B-Cell Acute Lymphoblastic Leukemia Using Quantitative Phase Imaging and Machine Learning. Ayyappan V, Chang A, Zhang C, Paidi SK, Bordett R, Liang T, Barman I, Pandey R ACS sensors 33092347 ACS Sens 2020 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/33092347
Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors. Yuan Y, Raj P, Zhang J, Siddhanta S, Barman I, Bulte JWM Angewandte Chemie (International ed. in English) 33325142 Angew Chem Int Ed Engl 2021 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/33325142
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A Dual-Modal Single-Antibody Plasmonic Spectro-Immunoassay for Detection of Small Molecules. Zheng P, Wu L, Raj P, Mizutani T, Szabo M, Hanson WA, Barman I Small (Weinheim an der Bergstrasse, Germany) 35373504 Small 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35373504
Non-Perturbative Identification and Subtyping of Amyloidosis in Human Kidney Tissue with Raman Spectroscopy and Machine Learning. Kim JH, Zhang C, Sperati CJ, Bagnasco SM, Barman I Biosensors 37185541 Biosensors (Basel) 2023 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/37185541
Rapid, Label-free Optical Spectroscopy Platform for Diagnosis of Heparin-Induced Thrombocytopenia. Huang Z, Siddhanta S, Zheng G, Kickler T, Barman I Angewandte Chemie (International ed. in English) 31972060 Angew Chem Int Ed Engl 2020 Apr 6 https://www.ncbi.nlm.nih.gov/pubmed/31972060
Spectroscopy-Assisted Label-free Molecular Analysis of Live Cell Surface with Vertically Aligned Plasmonic Nanopillars. Zhang C, Siddhanta S, Paria D, Li Y, Zheng C, Barman I Small (Weinheim an der Bergstrasse, Germany) 33942486 Small 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33942486
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Raman and quantitative phase imaging allow morpho-molecular recognition of malignancy and stages of B-cell acute lymphoblastic leukemia. Paidi SK, Raj P, Bordett R, Zhang C, Karandikar SH, Pandey R, Barman I Biosensors & bioelectronics 34130086 Biosens Bioelectron 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34130086
Self-Folding Hybrid Graphene Skin for 3D Biosensing. Xu W, Paidi SK, Qin Z, Huang Q, Yu CH, Pagaduan JV, Buehler MJ, Barman I, Gracias DH Nano letters 30433789 Nano Lett 2019 Mar 13 https://www.ncbi.nlm.nih.gov/pubmed/30433789
Composite-Scattering Plasmonic Nanoprobes for Label-Free, Quantitative Biomolecular Sensing. Zhang C, Paria D, Semancik S, Barman I Small (Weinheim an der Bergstrasse, Germany) 31394029 Small 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31394029
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Quantitative Detection of Thyroid-Stimulating Hormone in Patient Samples with a Nanomechanical Single-Antibody Spectro-Immunoassay. Zheng P, Raj P, Wu L, Mizutani T, Szabo M, Hanson WA, Barman I Small (Weinheim an der Bergstrasse, Germany) 37752776 Small 2024 Feb https://www.ncbi.nlm.nih.gov/pubmed/37752776
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MRBLE-pep Measurements Reveal Accurate Binding Affinities for B56, a PP2A Regulatory Subunit. Hein JB, Cyert MS, Fordyce PM ACS measurement science au 35128539 ACS Meas Sci Au 2021 Oct 20 https://www.ncbi.nlm.nih.gov/pubmed/35128539
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Cell cycle dynamics in the reprogramming of cellular identity. Hu X, Eastman AE, Guo S FEBS letters 31562821 FEBS Lett 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31562821
Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Hetzler PT 3rd, Dash BC, Guo S, Hsia HC Annals of plastic surgery 31246672 Ann Plast Surg 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31246672
Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter. Eastman AE, Chen X, Hu X, Hartman AA, Pearlman Morales AM, Yang C, Lu J, Kueh HY, Guo S Cell reports 32579930 Cell Rep 2020 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/32579930
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Reprogramming progressive cells display low CAG promoter activity. Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park IH, Guo S Stem cells (Dayton, Ohio) 33075202 Stem Cells 2021 Jan https://www.ncbi.nlm.nih.gov/pubmed/33075202
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Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Lin YT, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP Blood advances 31698452 Blood Adv 2019 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/31698452
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG 3rd, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP Nature communications 32321912 Nat Commun 2020 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/32321912
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA Proceedings of the National Academy of Sciences of the United States of America 33093202 Proc Natl Acad Sci U S A 2020 Nov 10 https://www.ncbi.nlm.nih.gov/pubmed/33093202
Seeking Convergence and Cure with New Myeloma Therapies. Choudhry P, Galligan D, Wiita AP Trends in cancer 30064664 Trends Cancer 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30064664
CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M Blood advances 32589729 Blood Adv 2020 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/32589729
Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik A, Stieglitz E, Wiita AP Cancer discovery 33727310 Cancer Discov 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/33727310
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Increasing proteomics throughput. Slavov N Nature biotechnology 33767394 Nat Biotechnol 2021 Jul https://www.ncbi.nlm.nih.gov/pubmed/33767394
DART-ID increases single-cell proteome coverage. Chen AT, Franks A, Slavov N PLoS computational biology 31260443 PLoS Comput Biol 2019 Jul https://www.ncbi.nlm.nih.gov/pubmed/31260443
DO-MS: Data-Driven Optimization of Mass Spectrometry Methods. Huffman RG, Chen A, Specht H, Slavov N Journal of proteome research 31081635 J Proteome Res 2019 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/31081635
Approaches for Studying Ribosome Specialization. Emmott E, Jovanovic M, Slavov N Trends in biochemical sciences 30792028 Trends Biochem Sci 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30792028
Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments. Gatto L, Aebersold R, Cox J, Demichev V, Derks J, Emmott E, Franks AM, Ivanov AR, Kelly RT, Khoury L, Leduc A, MacCoss MJ, Nemes P, Perlman DH, Petelski AA, Rose CM, Schoof EM, Van Eyk J, Vanderaa C, Yates JR 3rd, Slavov N Nature methods 36864200 Nat Methods 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/36864200
Driving Single Cell Proteomics Forward with Innovation. Slavov N Journal of proteome research 34597050 J Proteome Res 2021 Nov 5 https://www.ncbi.nlm.nih.gov/pubmed/34597050
Post-transcriptional regulation across human tissues. Franks A, Airoldi E, Slavov N PLoS computational biology 28481885 PLoS Comput Biol 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28481885
Quantifying Homologous Proteins and Proteoforms. Malioutov D, Chen T, Airoldi E, Jaffe J, Budnik B, Slavov N Molecular & cellular proteomics : MCP 30282776 Mol Cell Proteomics 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30282776
Optimizing Accuracy and Depth of Protein Quantification in Experiments Using Isobaric Carriers. Specht H, Slavov N Journal of proteome research 33190502 J Proteome Res 2021 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/33190502
Measuring Protein Shapes in Living Cells. Slavov N Journal of proteome research 33988997 J Proteome Res 2021 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/33988997
Voices of biotech research. Annabi N, Baker M, Boettiger A, Chakraborty D, Chen Y, Corbett KS, Correia B, Dahlman J, de Oliveira T, Ertuerk A, Yanik MF, Henaff E, Huch M, Iliev ID, Jacobs T, Junca H, Keung A, Kolodkin-Gal I, Krishnaswamy S, Lancaster M, Macosko E, Martínez-Núñez MA, Miura K, Molloy J, Cruz AO, Platt RJ, Posey AD Jr, Shao H, Simunovic M, Slavov N, Takebe T, Vandenberghe LH, Varshney RK, Wang J Nature biotechnology 33692517 Nat Biotechnol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33692517
Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2. Specht H, Emmott E, Petelski AA, Huffman RG, Perlman DH, Serra M, Kharchenko P, Koller A, Slavov N Genome biology 33504367 Genome Biol 2021 Jan 27 https://www.ncbi.nlm.nih.gov/pubmed/33504367
Scaling Up Single-Cell Proteomics. Slavov N Molecular & cellular proteomics : MCP 34808355 Mol Cell Proteomics 2022 Jan https://www.ncbi.nlm.nih.gov/pubmed/34808355
Proteome asymmetry in mouse and human embryos before fate specification. Iwamoto-Stohl LK, Petelski AA, Meglicki M, Fu A, Khan S, Specht H, Huffman G, Derks J, Jorgensen V, Weatherbee BAT, Weberling A, Gantner CW, Mandelbaum RS, Paulson RJ, Lam L, Ahmady A, Vasquez ES, Slavov N, Zernicka-Goetz M bioRxiv : the preprint server for biology 39253500 bioRxiv 2024 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/39253500
Fertilization triggers early proteomic symmetry breaking in mammalian embryos. Iwamoto-Stohl LK, Petelski AA, Quan B, Meglicki M, Fu A, Nakagawa S, McMahon B, Wang TY, Khan S, Specht H, Huffman G, Derks J, Junyent S, Weatherbee BAT, Weberling A, Gantner CW, Mandelbaum RS, Paulson RJ, Lam L, Chou TF, Slavov N, Zernicka-Goetz M Cell 41344326 Cell 2025 Dec 24 https://www.ncbi.nlm.nih.gov/pubmed/41344326
Multiplexed single-cell proteomics using SCoPE2. Petelski AA, Emmott E, Leduc A, Huffman RG, Specht H, Perlman DH, Slavov N Nature protocols 34716448 Nat Protoc 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34716448
Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel. Liu Y, LoCaste CE, Liu W, Poltash ML, Russell DH, Laganowsky A Nature communications 30902995 Nat Commun 2019 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/30902995
Investigation of Protein-Lipid Interactions Using Native Mass Spectrometry. Cong X, Patrick JW, Liu Y, Liang X, Liu W, Laganowsky A Methods in molecular biology (Clifton, N.J.) 34718990 Methods Mol Biol 2022 https://www.ncbi.nlm.nih.gov/pubmed/34718990
Cupric Ions Selectively Modulate TRAAK-Phosphatidylserine Interactions. Zhu Y, Schrecke S, Tang S, Odenkirk MT, Walker T, Stover L, Lyu J, Zhang T, Russell D, Baker ES, Yan X, Laganowsky A Journal of the American Chemical Society 35421309 J Am Chem Soc 2022 Apr 27 https://www.ncbi.nlm.nih.gov/pubmed/35421309
Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions. Lyu J, Zhang T, Marty MT, Clemmer D, Russell DH, Laganowsky A bioRxiv : the preprint server for biology 37461710 bioRxiv 2023 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/37461710
Generation of Charge-Reduced Ions of Membrane Protein Complexes for Native Ion Mobility Mass Spectrometry Studies. Patrick JW, Laganowsky A Journal of the American Society for Mass Spectrometry 30887461 J Am Soc Mass Spectrom 2019 May https://www.ncbi.nlm.nih.gov/pubmed/30887461
Variable-Temperature ESI-IMS-MS Analysis of Myohemerythrin Reveals Ligand Losses, Unfolding, and a Non-Native Disulfide Bond. Woodall DW, El-Baba TJ, Fuller DR, Liu W, Brown CJ, Laganowsky A, Russell DH, Clemmer DE Analytical chemistry 31038926 Anal Chem 2019 May 21 https://www.ncbi.nlm.nih.gov/pubmed/31038926
A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Khan D, Lee D, Gulten G, Aggarwal A, Wofford J, Krieger I, Tripathi A, Patrick JW, Eckert DM, Laganowsky A, Sacchettini J, Lindahl P, Bankaitis VA eLife 32780017 Elife 2020 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/32780017
Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions. Qiao P, Schrecke S, Walker T, McCabe JW, Lyu J, Zhu Y, Zhang T, Kumar S, Clemmer D, Russell DH, Laganowsky A The journal of physical chemistry letters 34928154 J Phys Chem Lett 2021 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/34928154
Variable-Temperature Native Mass Spectrometry for Studies of Protein Folding, Stabilities, Assembly, and Molecular Interactions. Laganowsky A, Clemmer DE, Russell DH Annual review of biophysics 34932911 Annu Rev Biophys 2022 May 9 https://www.ncbi.nlm.nih.gov/pubmed/34932911
Variable-Temperature Electrospray Ionization for Temperature-Dependent Folding/Refolding Reactions of Proteins and Ligand Binding. McCabe JW, Shirzadeh M, Walker TE, Lin CW, Jones BJ, Wysocki VH, Barondeau DP, Clemmer DE, Laganowsky A, Russell DH Analytical chemistry 33904705 Anal Chem 2021 May 11 https://www.ncbi.nlm.nih.gov/pubmed/33904705
Native IM-Orbitrap MS: Resolving What Was Hidden. Poltash ML, McCabe JW, Shirzadeh M, Laganowsky A, Russell DH Trends in analytical chemistry : TRAC 32189816 Trends Analyt Chem 2020 Mar https://www.ncbi.nlm.nih.gov/pubmed/32189816
Allosteric modulation of protein-protein interactions by individual lipid binding events. Cong X, Liu Y, Liu W, Liang X, Laganowsky A Nature communications 29259178 Nat Commun 2017 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/29259178
Enhanced Characterization of Membrane Protein Complexes by Ultraviolet Photodissociation Mass Spectrometry. Sipe SN, Patrick JW, Laganowsky A, Brodbelt JS Analytical chemistry 31765130 Anal Chem 2020 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/31765130
Evidence for Many Unique Solution Structures for Chymotrypsin Inhibitor 2: A Thermodynamic Perspective Derived from vT-ESI-IMS-MS Measurements. Raab SA, El-Baba TJ, Woodall DW, Liu W, Liu Y, Baird Z, Hales DA, Laganowsky A, Russell DH, Clemmer DE Journal of the American Chemical Society 32866376 J Am Chem Soc 2020 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/32866376
First-Principles Collision Cross Section Measurements of Large Proteins and Protein Complexes. McCabe JW, Mallis CS, Kocurek KI, Poltash ML, Shirzadeh M, Hebert MJ, Fan L, Walker TE, Zheng X, Jiang T, Dong S, Lin CW, Laganowsky A, Russell DH Analytical chemistry 32662991 Anal Chem 2020 Aug 18 https://www.ncbi.nlm.nih.gov/pubmed/32662991
Development and Evaluation of a Reverse-Entry Ion Source Orbitrap Mass Spectrometer. Poltash ML, McCabe JW, Patrick JW, Laganowsky A, Russell DH Journal of the American Society for Mass Spectrometry 29796735 J Am Soc Mass Spectrom 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/29796735
Implementing Digital-Waveform Technology for Extended m/z Range Operation on a Native Dual-Quadrupole FT-IM-Orbitrap Mass Spectrometer. McCabe JW, Jones BJ, Walker TE, Schrader RL, Huntley AP, Lyu J, Hoffman NM, Anderson GA, Reilly PTA, Laganowsky A, Wysocki VH, Russell DH Journal of the American Society for Mass Spectrometry 34797072 J Am Soc Mass Spectrom 2021 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/34797072
Insight into the Phospholipid-Binding Preferences of Kir3.4. Qiao P, Schrecke S, Lyu J, Zhu Y, Zhang T, Benavides A, Laganowsky A Biochemistry 34846128 Biochemistry 2021 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/34846128
Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions. Lyu J, Zhang T, Marty MT, Clemmer D, Russell DH, Laganowsky A eLife 38252560 Elife 2024 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/38252560
Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays. Movva R, Greenside P, Marinov GK, Nair S, Shrikumar A, Kundaje A PloS one 31206543 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/31206543
Discovering epistatic feature interactions from neural network models of regulatory DNA sequences. Greenside P, Shimko T, Fordyce P, Kundaje A Bioinformatics (Oxford, England) 30423062 Bioinformatics 2018 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/30423062
Opportunities and obstacles for deep learning in biology and medicine. Ching T, Himmelstein DS, Beaulieu-Jones BK, Kalinin AA, Do BT, Way GP, Ferrero E, Agapow PM, Zietz M, Hoffman MM, Xie W, Rosen GL, Lengerich BJ, Israeli J, Lanchantin J, Woloszynek S, Carpenter AE, Shrikumar A, Xu J, Cofer EM, Lavender CA, Turaga SC, Alexandari AM, Lu Z, Harris DJ, DeCaprio D, Qi Y, Kundaje A, Peng Y, Wiley LK, Segler MHS, Boca SM, Swamidass SJ, Huang A, Gitter A, Greene CS Journal of the Royal Society, Interface 29618526 J R Soc Interface 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29618526
Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin. Yang D, Denny SK, Greenside PG, Chaikovsky AC, Brady JJ, Ouadah Y, Granja JM, Jahchan NS, Lim JS, Kwok S, Kong CS, Berghoff AS, Schmitt A, Reinhardt HC, Park KS, Preusser M, Kundaje A, Greenleaf WJ, Sage J, Winslow MM Cancer discovery 30228179 Cancer Discov 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30228179
Prediction of protein-ligand interactions from paired protein sequence motifs and ligand substructures. Greenside P, Hillenmeyer M, Kundaje A Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 29218866 Pac Symp Biocomput 2018 https://www.ncbi.nlm.nih.gov/pubmed/29218866
NETWORK MODELLING OF TOPOLOGICAL DOMAINS USING HI-C DATA. Wang YXR, Sarkar P, Ursu O, Kundaje A, Bickel PJ The annals of applied statistics 32968472 Ann Appl Stat 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/32968472
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease. Ameen M, Sundaram L, Shen M, Banerjee A, Kundu S, Nair S, Shcherbina A, Gu M, Wilson KD, Varadarajan A, Vadgama N, Balsubramani A, Wu JC, Engreitz JM, Farh K, Karakikes I, Wang KC, Quertermous T, Greenleaf WJ, Kundaje A Cell 36563664 Cell 2022 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/36563664
Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis. Liu X, Sun T, Shcherbina A, Li Q, Jarmoskaite I, Kappel K, Ramaswami G, Das R, Kundaje A, Li JB Nature communications 33846332 Nat Commun 2021 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/33846332
Domain-adaptive neural networks improve cross-species prediction of transcription factor binding. Cochran K, Srivastava D, Shrikumar A, Balsubramani A, Hardison RC, Kundaje A, Mahony S Genome research 35042722 Genome Res 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35042722
Transcription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum. Marinov GK, Trevino AE, Xiang T, Kundaje A, Grossman AR, Greenleaf WJ Nature genetics 33927397 Nat Genet 2021 May https://www.ncbi.nlm.nih.gov/pubmed/33927397
Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study. Wainberg M, Mahajan A, Kundaje A, McCarthy MI, Ingelsson E, Sinnott-Armstrong N, Rivas MA PLoS medicine 31821322 PLoS Med 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31821322
Transparency and reproducibility in artificial intelligence. Haibe-Kains B, Adam GA, Hosny A, Khodakarami F, Massive Analysis Quality Control (MAQC) Society Board of Directors, Waldron L, Wang B, McIntosh C, Goldenberg A, Kundaje A, Greene CS, Broderick T, Hoffman MM, Leek JT, Korthauer K, Huber W, Brazma A, Pineau J, Tibshirani R, Hastie T, Ioannidis JPA, Quackenbush J, Aerts HJWL Nature 33057217 Nature 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33057217
Denoising genome-wide histone ChIP-seq with convolutional neural networks. Koh PW, Pierson E, Kundaje A Bioinformatics (Oxford, England) 28881977 Bioinformatics 2017 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/28881977
ChIP-ping the branches of the tree: functional genomics and the evolution of eukaryotic gene regulation. Marinov GK, Kundaje A Briefings in functional genomics 29529131 Brief Funct Genomics 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29529131
GenomeDISCO: a concordance score for chromosome conformation capture experiments using random walks on contact map graphs. Ursu O, Boley N, Taranova M, Wang YXR, Yardimci GG, Stafford Noble W, Kundaje A Bioinformatics (Oxford, England) 29554289 Bioinformatics 2018 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/29554289
Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts. Nair S, Kim DS, Perricone J, Kundaje A Bioinformatics (Oxford, England) 31510655 Bioinformatics 2019 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/31510655
GkmExplain: fast and accurate interpretation of nonlinear gapped k-mer SVMs. Shrikumar A, Prakash E, Kundaje A Bioinformatics (Oxford, England) 31510661 Bioinformatics 2019 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/31510661
The chromatin landscape of the euryarchaeon Haloferax volcanii. Marinov GK, Bagdatli ST, Wu T, He C, Kundaje A, Greenleaf WJ Genome biology 37932847 Genome Biol 2023 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/37932847
Accelerating in silico saturation mutagenesis using compressed sensing. Schreiber J, Nair S, Balsubramani A, Kundaje A Bioinformatics (Oxford, England) 35678521 Bioinformatics 2022 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/35678521
Opportunities and challenges for transcriptome-wide association studies. Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A Nature genetics 30926968 Nat Genet 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30926968
Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells Primed for Differentiation. Shcherbina A, Li J, Narayanan C, Greenleaf W, Kundaje A, Chetty S Stem cells (Dayton, Ohio) 31135093 Stem Cells 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31135093
The Kipoi repository accelerates community exchange and reuse of predictive models for genomics. Avsec Ž, Kreuzhuber R, Israeli J, Xu N, Cheng J, Shrikumar A, Banerjee A, Kim DS, Beier T, Urban L, Kundaje A, Stegle O, Gagneur J Nature biotechnology 31138913 Nat Biotechnol 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31138913
fastISM: performant in silico saturation mutagenesis for convolutional neural networks. Nair S, Shrikumar A, Schreiber J, Kundaje A Bioinformatics (Oxford, England) 35238376 Bioinformatics 2022 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/35238376
Base-resolution models of transcription-factor binding reveal soft motif syntax. Avsec Ž, Weilert M, Shrikumar A, Krueger S, Alexandari A, Dalal K, Fropf R, McAnany C, Gagneur J, Kundaje A, Zeitlinger J Nature genetics 33603233 Nat Genet 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33603233
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation. Kim DS, Risca VI, Reynolds DL, Chappell J, Rubin AJ, Jung N, Donohue LKH, Lopez-Pajares V, Kathiria A, Shi M, Zhao Z, Deep H, Sharmin M, Rao D, Lin S, Chang HY, Snyder MP, Greenleaf WJ, Kundaje A, Khavari PA Nature genetics 34650237 Nat Genet 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34650237
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability. Greenstein RA, Barrales RR, Sanchez NA, Bisanz JE, Braun S, Al-Sady B Genes & development 31805521 Genes Dev 2020 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/31805521
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states. Murawska M, Greenstein RA, Schauer T, Olsen KCF, Ng H, Ladurner AG, Al-Sady B, Braun S Cell reports 34731638 Cell Rep 2021 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/34731638
Heterodimerization of H3K9 histone methyltransferases G9a and GLP activates methyl reading and writing capabilities. Sanchez NA, Kallweit LM, Trnka MJ, Clemmer CL, Al-Sady B The Journal of biological chemistry 34619147 J Biol Chem 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34619147
Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability. Greenstein RA, Jones SK, Spivey EC, Rybarski JR, Finkelstein IJ, Al-Sady B eLife 30020075 Elife 2018 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/30020075
Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading. Kennedy DR, Lemière J, Amine AA, Martin EW, Tan C, Simental E, Braxton J, Maxwell RA, Al-Sady B bioRxiv : the preprint server for biology 39554105 bioRxiv 2025 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/39554105
Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading. Kennedy DR, Lemière J, Amine AAA, Martin EW, Tan C, Simental E, Braxton J, Maxwell RA, Al-Sady B Nucleic acids research 41385327 Nucleic Acids Res 2025 Nov 26 https://www.ncbi.nlm.nih.gov/pubmed/41385327
Epigenetic fates of gene silencing established by heterochromatin spreading in cell identity and genome stability. Greenstein RA, Al-Sady B Current genetics 30390097 Curr Genet 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30390097
Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction. Greenstein RA, Ng H, Barrales RR, Tan C, Braun S, Al-Sady B PLoS genetics 35584134 PLoS Genet 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35584134
Assembly and early maturation of large subunit precursors. Chaker-Margot M, Klinge S RNA (New York, N.Y.) 30670483 RNA 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30670483
Conformational switches control early maturation of the eukaryotic small ribosomal subunit. Hunziker M, Barandun J, Buzovetsky O, Steckler C, Molina H, Klinge S eLife 31206356 Elife 2019 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/31206356
Assembly and structure of the SSU processome-a nucleolar precursor of the small ribosomal subunit. Barandun J, Hunziker M, Klinge S Current opinion in structural biology 29414516 Curr Opin Struct Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29414516
Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome. Barandun J, Hunziker M, Vossbrinck CR, Klinge S Nature microbiology 31332387 Nat Microbiol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31332387
The complete structure of the small-subunit processome. Barandun J, Chaker-Margot M, Hunziker M, Molloy KR, Chait BT, Klinge S Nature structural & molecular biology 28945246 Nat Struct Mol Biol 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28945246
Nucleolar maturation of the human small subunit processome. Singh S, Vanden Broeck A, Miller L, Chaker-Margot M, Klinge S Science (New York, N.Y.) 34516797 Science 2021 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/34516797
Modular assembly of the nucleolar pre-60S ribosomal subunit. Sanghai ZA, Miller L, Molloy KR, Barandun J, Hunziker M, Chaker-Margot M, Wang J, Chait BT, Klinge S Nature 29512650 Nature 2018 Apr 5 https://www.ncbi.nlm.nih.gov/pubmed/29512650
Ribosome assembly coming into focus. Klinge S, Woolford JL Jr Nature reviews. Molecular cell biology 30467428 Nat Rev Mol Cell Biol 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30467428
Live Cell Imaging Reveals pH Oscillations in Saccharomyces cerevisiae During Metabolic Transitions. Dodd BJT, Kralj JM Scientific reports 29066766 Sci Rep 2017 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/29066766
Finding the Spark. Kralj JM Bioelectricity 34476390 Bioelectricity 2021 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/34476390
Genome-Wide Functional Screen for Calcium Transients in Escherichia coli Identifies Increased Membrane Potential Adaptation to Persistent DNA Damage. Luder R, Bruni GN, Kralj JM Journal of bacteriology 33199283 J Bacteriol 2021 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/33199283
Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides. Bruni GN, Kralj JM eLife 32748785 Elife 2020 Aug 4 https://www.ncbi.nlm.nih.gov/pubmed/32748785
Machine Learning Establishes Single-Cell Calcium Dynamics as an Early Indicator of Antibiotic Response. Meyer CT, Jewell MP, Miller EJ, Kralj JM Microorganisms 34063175 Microorganisms 2021 May 5 https://www.ncbi.nlm.nih.gov/pubmed/34063175
High Throughput Viability Assay for Microbiology. Meyer CT, Lynch GK, Stamo DF, Miller EJ, Chatterjee A, Kralj JM bioRxiv : the preprint server for biology 36712102 bioRxiv 2023 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/36712102
Voltage-gated calcium flux mediates Escherichia coli mechanosensation. Bruni GN, Weekley RA, Dodd BJT, Kralj JM Proceedings of the National Academy of Sciences of the United States of America 28808010 Proc Natl Acad Sci U S A 2017 Aug 29 https://www.ncbi.nlm.nih.gov/pubmed/28808010
A high-throughput and low-waste viability assay for microbes. Meyer CT, Lynch GK, Stamo DF, Miller EJ, Chatterjee A, Kralj JM Nature microbiology 37919425 Nat Microbiol 2023 Dec https://www.ncbi.nlm.nih.gov/pubmed/37919425
Phage therapy administered noninvasively could be effective in thin tubes subject to episodic flow despite washout: a simulation study. Blanco C, Chen IA Physical biology 31266001 Phys Biol 2019 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/31266001
Sparse Bayesian Group Factor Model for Feature Interactions in Multiple Count Tables Data. Zhang S, Shen Y, Chen IA, Lee J Journal of the American Statistical Association 40678201 J Am Stat Assoc 2025 https://www.ncbi.nlm.nih.gov/pubmed/40678201
Treatment of Wound Infections in a Mouse Model Using Zn(2+)-Releasing Phage Bound to Gold Nanorods. Peng H, Rossetto D, Mansy SS, Jordan MC, Roos KP, Chen IA ACS nano 35239330 ACS Nano 2022 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/35239330
Phage engineering and the evolutionary arms race. Peng H, Chen IA Current opinion in biotechnology 33113495 Curr Opin Biotechnol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33113495
Modulation of α-Synuclein Aggregation In Vitro by a DNA Aptamer. Tran CH, Saha R, Blanco C, Bagchi D, Chen IA Biochemistry 35994742 Biochemistry 2022 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/35994742
Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes. Janzen E, Shen Y, Vázquez-Salazar A, Liu Z, Blanco C, Kenchel J, Chen IA Nature communications 35752631 Nat Commun 2022 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/35752631
Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution. Janzen E, Blanco C, Peng H, Kenchel J, Chen IA Chemical reviews 32011135 Chem Rev 2020 Jun 10 https://www.ncbi.nlm.nih.gov/pubmed/32011135
Self-cleaving ribozymes: substrate specificity and synthetic biology applications. Peng H, Latifi B, Müller S, Lupták A, Chen IA RSC chemical biology 34704043 RSC Chem Biol 2021 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/34704043
Kinetic sequencing (k-Seq) as a massively parallel assay for ribozyme kinetics: utility and critical parameters. Shen Y, Pressman A, Janzen E, Chen IA Nucleic acids research 33772580 Nucleic Acids Res 2021 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/33772580
A Bayesian nonparametric analysis for zero-inflated multivariate count data with application to microbiome study. Shuler K, Verbanic S, Chen IA, Lee J Journal of the Royal Statistical Society. Series C, Applied statistics 37440868 J R Stat Soc Ser C Appl Stat 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/37440868
Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. Verbanic S, Kim CY, Deacon JM, Chen IA BMC microbiology 31488062 BMC Microbiol 2019 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/31488062
Visualization of Engineered M13 Phages Bound to Bacterial Targets by Transmission Electron Microscopy. Yang Y, Chen IA Methods in molecular biology (Clifton, N.J.) 38526731 Methods Mol Biol 2024 https://www.ncbi.nlm.nih.gov/pubmed/38526731
PacBio sequencing output increased through uniform and directional fivefold concatenation. Kanwar N, Blanco C, Chen IA, Seelig B Scientific reports 34508117 Sci Rep 2021 Sep 10 https://www.ncbi.nlm.nih.gov/pubmed/34508117
Vesicle encapsulation stabilizes intermolecular association and structure formation of functional RNA and DNA. Peng H, Lelievre A, Landenfeld K, Müller S, Chen IA Current biology : CB 34762821 Curr Biol 2022 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/34762821
Chimeric Phage Nanoparticles for Rapid Characterization of Bacterial Pathogens: Detection in Complex Biological Samples and Determination of Antibiotic Sensitivity. Peng H, Borg RE, Nguyen ABN, Chen IA ACS sensors 32314570 ACS Sens 2020 May 22 https://www.ncbi.nlm.nih.gov/pubmed/32314570
Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds. Verbanic S, Shen Y, Lee J, Deacon JM, Chen IA NPJ biofilms and microbiomes 32358500 NPJ Biofilms Microbiomes 2020 May 1 https://www.ncbi.nlm.nih.gov/pubmed/32358500
EasyDIVER: A Pipeline for Assembling and Counting High-Throughput Sequencing Data from In Vitro Evolution of Nucleic Acids or Peptides. Blanco C, Verbanic S, Seelig B, Chen IA Journal of molecular evolution 32529275 J Mol Evol 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32529275
Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages. Peng H, Borg RE, Dow LP, Pruitt BL, Chen IA Proceedings of the National Academy of Sciences of the United States of America 31932441 Proc Natl Acad Sci U S A 2020 Jan 28 https://www.ncbi.nlm.nih.gov/pubmed/31932441
Biosourced Functional Hydroxybenzoate-co-Lactide Polymers with Antimicrobial Activity. Salas-Ambrosio P, Vexler S, P Sivasankaran R, Vlahakis N, Lai RS, Johnson C, Baas-Maynard SI, Min DS, Lower H, Doyle AG, Tang Y, Rodriguez JA, Chen IA, Read de Alaniz J, Maynard HD Journal of the American Chemical Society 40380948 J Am Chem Soc 2025 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/40380948
Rapid Colorimetric Detection of Bacterial Species through the Capture of Gold Nanoparticles by Chimeric Phages. Peng H, Chen IA ACS nano 30586498 ACS Nano 2019 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/30586498
The Chronic Wound Phageome: Phage Diversity and Associations with Wounds and Healing Outcomes. Verbanic S, Deacon JM, Chen IA Microbiology spectrum 35435739 Microbiol Spectr 2022 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/35435739
Effects of Preservation and Propagation Methodology on Microcosms Derived from the Oral Microbiome. Zhou B, Mobberley J, Shi K, Chen IA Microorganisms 36363738 Microorganisms 2022 Oct 29 https://www.ncbi.nlm.nih.gov/pubmed/36363738
High throughput sequencing of in vitro selections of mRNA-displayed peptides: data analysis and applications. Blanco C , Verbanic S , Seelig B , Chen IA Physical chemistry chemical physics : PCCP 31967131 Phys Chem Chem Phys 2020 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/31967131
Preparation of Bioconjugates of Chimeric M13 Phage and Gold Nanorods. Peng H, Chen IA Methods in molecular biology (Clifton, N.J.) 38526728 Methods Mol Biol 2024 https://www.ncbi.nlm.nih.gov/pubmed/38526728
Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy. Kang D, Bagchi D, Chen IA Advanced therapeutics 38933919 Adv Ther (Weinh) 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38933919
Genetically engineered filamentous phage for bacterial detection using magnetic resonance imaging. Borg RE, Ozbakir HF, Xu B, Li E, Fang X, Peng H, Chen IA, Mukherjee A Sensors & diagnostics 38405385 Sens Diagn 2023 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/38405385
Identification of a Master Regulator of Differentiation in Toxoplasma. Waldman BS, Schwarz D, Wadsworth MH 2nd, Saeij JP, Shalek AK, Lourido S Cell 31955846 Cell 2020 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/31955846
Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity. Burbage M, Gasparrini F, Aggarwal S, Gaya M, Arnold J, Nair U, Way M, Bruckbauer A, Batista FD eLife 29337666 Elife 2018 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/29337666
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. Genshaft AS, Ziegler CGK, Tzouanas CN, Mead BE, Jaeger AM, Navia AW, King RP, Mana MD, Huang S, Mitsialis V, Snapper SB, Yilmaz ÖH, Jacks T, Van Humbeck JF, Shalek AK Nature communications 34404785 Nat Commun 2021 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/34404785
Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Jacobsen JT, Hu W, R Castro TB, Solem S, Galante A, Lin Z, Allon SJ, Mesin L, Bilate AM, Schiepers A, Shalek AK, Rudensky AY, Victora GD Science (New York, N.Y.) 34437125 Science 2021 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/34437125
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Mead BE, Hattori K, Levy L, Imada S, Goto N, Vukovic M, Sze D, Kummerlowe C, Matute JD, Duan J, Langer R, Blumberg RS, Ordovas-Montanes J, Yilmaz ÖH, Karp JM, Shalek AK Nature biomedical engineering 35314801 Nat Biomed Eng 2022 Apr https://www.ncbi.nlm.nih.gov/pubmed/35314801
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction. Genshaft AS, Li S, Gallant CJ, Darmanis S, Prakadan SM, Ziegler CG, Lundberg M, Fredriksson S, Hong J, Regev A, Livak KJ, Landegren U, Shalek AK Genome biology 27640647 Genome Biol 2016 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/27640647
Mapping Causal Variants with Single-Nucleotide Resolution Reveals Biochemical Drivers of Phenotypic Change. She R, Jarosz DF Cell 29373829 Cell 2018 Jan 25 https://www.ncbi.nlm.nih.gov/pubmed/29373829
A prion accelerates proliferation at the expense of lifespan. Garcia DM, Campbell EA, Jakobson CM, Tsuchiya M, Shaw EA, DiNardo AL, Kaeberlein M, Jarosz DF eLife 34545808 Elife 2021 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/34545808
Protein self-assembly: A new frontier in cell signaling. Saad S, Jarosz DF Current opinion in cell biology 33493989 Curr Opin Cell Biol 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33493989
A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program. Chakravarty AK, Smejkal T, Itakura AK, Garcia DM, Jarosz DF Molecular cell 31757755 Mol Cell 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31757755
A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness. Jakobson CM, Hartl J, Trébulle P, Mülleder M, Jarosz DF, Ralser M Science (New York, N.Y.) 41066569 Science 2025 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/41066569
Protein-Based Inheritance: Epigenetics beyond the Chromosome. Harvey ZH, Chen Y, Jarosz DF Molecular cell 29153393 Mol Cell 2018 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/29153393
High-throughput Screening for Protein-based Inheritance in S. cerevisiae. Byers JS, Jarosz DF Journal of visualized experiments : JoVE 28809826 J Vis Exp 2017 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/28809826
Mutations, protein homeostasis, and epigenetic control of genome integrity. Xie JL, Jarosz DF DNA repair 30181040 DNA Repair (Amst) 2018 Nov https://www.ncbi.nlm.nih.gov/pubmed/30181040
The Hunt for Ancient Prions: Archaeal Prion-Like Domains Form Amyloid-Based Epigenetic Elements. Zajkowski T, Lee MD, Mondal SS, Carbajal A, Dec R, Brennock PD, Piast RW, Snyder JE, Bense NB, Dzwolak W, Jarosz DF, Rothschild LJ Molecular biology and evolution 33480998 Mol Biol Evol 2021 May 4 https://www.ncbi.nlm.nih.gov/pubmed/33480998
Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships. Jakobson CM, Jarosz DF Cell systems 31054809 Cell Syst 2019 May 22 https://www.ncbi.nlm.nih.gov/pubmed/31054809
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation. Aguilar-Rodriguez J, Vila JCC, Chen SA, Razo-Mejia M, Ghosh OM, Jarosz DF, Fraser HB, Petrov DA bioRxiv : the preprint server for biology 39553990 bioRxiv 2025 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/39553990
Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate. Chen YR, Harel I, Singh PP, Ziv I, Moses E, Goshtchevsky U, Machado BE, Brunet A, Jarosz DF Developmental cell 38810654 Dev Cell 2024 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/38810654
The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective. Aguilar-Rodríguez J, Jakobson CM, Jarosz DF Journal of molecular biology 39481633 J Mol Biol 2024 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/39481633
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Chakrabortee S, Byers JS, Jones S, Garcia DM, Bhullar B, Chang A, She R, Lee L, Fremin B, Lindquist S, Jarosz DF Cell 27693355 Cell 2016 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/27693355
Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, Chakravarty AK, Layton CJ, Chircus LM, Andreasson JO, Damaraju N, McMahon PL, Buenrostro JD, Jarosz DF, Greenleaf WJ Proceedings of the National Academy of Sciences of the United States of America 28325876 Proc Natl Acad Sci U S A 2017 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/28325876
A common bacterial metabolite elicits prion-based bypass of glucose repression. Garcia DM, Dietrich D, Clardy J, Jarosz DF eLife 27906649 Elife 2016 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/27906649
More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change. Chakravarty AK, Jarosz DF Journal of molecular biology 30031007 J Mol Biol 2018 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/30031007
Protein aggregation and the evolution of stress resistance in clinical yeast. Chen YR, Ziv I, Swaminathan K, Elias JE, Jarosz DF Philosophical transactions of the Royal Society of London. Series B, Biological sciences 33866806 Philos Trans R Soc Lond B Biol Sci 2021 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/33866806
What Has a Century of Quantitative Genetics Taught Us About Nature's Genetic Tool Kit? Jakobson CM, Jarosz DF Annual review of genetics 32897739 Annu Rev Genet 2020 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/32897739
Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae. Jakobson CM, She R, Jarosz DF Nature communications 30874558 Nat Commun 2019 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/30874558
A genome-to-proteome atlas charts natural variants controlling proteome diversity and forecasts their fitness effects. Jakobson CM, Hartl J, Trébulle P, Mülleder M, Jarosz DF, Ralser M bioRxiv : the preprint server for biology 39484408 bioRxiv 2024 Oct 22 https://www.ncbi.nlm.nih.gov/pubmed/39484408
Stress-driven emergence of heritable non-genetic drug resistance. Xie JL, Yin S, Yang TS, Chandrasekher K, Hanson L, Kim SH, Esqueda L, Hogan CA, Banaei N, Round JL, Ost KS, Berman J, Jarosz DF Research square 41356366 Res Sq 2025 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/41356366
Protein structure shapes natural genetic variation and de novo adaptation. Jakobson CM, Van Elgort A, Aguilar-Rodríguez J, Jarosz DF bioRxiv : the preprint server for biology 41509306 bioRxiv 2025 Dec 22 https://www.ncbi.nlm.nih.gov/pubmed/41509306
A Prion Epigenetic Switch Establishes an Active Chromatin State. Harvey ZH, Chakravarty AK, Futia RA, Jarosz DF Cell 32109413 Cell 2020 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/32109413
Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae. Itakura AK, Chakravarty AK, Jakobson CM, Jarosz DF Molecular cell 31757756 Mol Cell 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31757756
Hsp90 shapes adaptation by controlling the fitness consequences of regulatory variation. Jakobson CM, Aguilar-Rodríguez J, Jarosz DF bioRxiv : the preprint server for biology 37961536 bioRxiv 2023 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/37961536
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M Nature neuroscience 35953545 Nat Neurosci 2022 Sep https://www.ncbi.nlm.nih.gov/pubmed/35953545
Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS Biology open 30037883 Biol Open 2018 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/30037883
Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT Nature biotechnology 29334369 Nat Biotechnol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29334369
Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. Kanfer G, Sarraf SA, Maman Y, Baldwin H, Dominguez-Martin E, Johnson KR, Ward ME, Kampmann M, Lippincott-Schwartz J, Youle RJ The Journal of cell biology 33464298 J Cell Biol 2021 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/33464298
The mTOR Complex Controls HIV Latency. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E Cell host & microbe 27978436 Cell Host Microbe 2016 Dec 14 https://www.ncbi.nlm.nih.gov/pubmed/27978436
CRISPulator: a discrete simulation tool for pooled genetic screens. Nagy T, Kampmann M BMC bioinformatics 28732459 BMC Bioinformatics 2017 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/28732459
Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Kampmann M Chemical communications (Cambridge, England) 28487920 Chem Commun (Camb) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28487920
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M The Journal of biological chemistry 31578281 J Biol Chem 2019 Dec 13 https://www.ncbi.nlm.nih.gov/pubmed/31578281
A CRISPR Approach to Neurodegenerative Diseases. Kampmann M Trends in molecular medicine 28478951 Trends Mol Med 2017 Jun https://www.ncbi.nlm.nih.gov/pubmed/28478951
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS eLife 27661255 Elife 2016 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/27661255
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS Scientific reports 29686391 Sci Rep 2018 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/29686391
Defining the ATPome reveals cross-optimization of metabolic pathways. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K Nature communications 32859923 Nat Commun 2020 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/32859923
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L Science (New York, N.Y.) 30765536 Science 2019 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/30765536
Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability. Abrams J, Arhar T, Mok SA, Taylor IR, Kampmann M, Gestwicki JE Cell stress & chaperones 33547632 Cell Stress Chaperones 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33547632
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS Cell 33838111 Cell 2021 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/33838111
CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M Neuron 31422865 Neuron 2019 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/31422865
NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems. Biebl MM, Delhommel F, Faust O, Zak KM, Agam G, Guo X, Mühlhofer M, Dahiya V, Hillebrand D, Popowicz GM, Kampmann M, Lamb DC, Rosenzweig R, Sattler M, Buchner J Molecular cell 35063133 Mol Cell 2022 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/35063133
A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K PLoS biology 30148842 PLoS Biol 2018 Aug https://www.ncbi.nlm.nih.gov/pubmed/30148842
LRP1 is a master regulator of tau uptake and spread. Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS Nature 32296178 Nature 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32296178
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M ACS chemical biology 32786289 ACS Chem Biol 2020 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/32786289
A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling. Semesta KM, Tian R, Kampmann M, von Zastrow M, Tsvetanova NG PLoS genetics 33052901 PLoS Genet 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33052901
CRISPR-based functional genomics for neurological disease. Kampmann M Nature reviews. Neurology 32641861 Nat Rev Neurol 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32641861
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ Cell 30053424 Cell 2018 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/30053424
An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J Cell 36638793 Cell 2023 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/36638793
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine. Kampmann M ACS chemical biology 29035510 ACS Chem Biol 2018 Feb 16 https://www.ncbi.nlm.nih.gov/pubmed/29035510
Mapping the Genetic Landscape of Human Cells. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA Cell 30033366 Cell 2018 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/30033366
Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster. Jorgensen V, Chen J, Vander Wende H, Harris DE, McCarthy A, Breznak S, Wong-Deyrup SW, Chen Y, Rangan P, Brar GA, Sawyer EM, Chan LY, Ünal E G3 (Bethesda, Md.) 32213532 G3 (Bethesda) 2020 May 4 https://www.ncbi.nlm.nih.gov/pubmed/32213532
Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. Cheng Z, Mugler CF, Keskin A, Hodapp S, Chan LY, Weis K, Mertins P, Regev A, Jovanovic M, Brar GA Molecular cell 30503772 Mol Cell 2019 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/30503772
Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells. Hollerer I, Barker JC, Jorgensen V, Tresenrider A, Dugast-Darzacq C, Chan LY, Darzacq X, Tjian R, Ünal E, Brar GA G3 (Bethesda, Md.) 30723103 G3 (Bethesda) 2019 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/30723103
Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast. Eisenberg AR, Higdon AL, Hollerer I, Fields AP, Jungreis I, Diamond PD, Kellis M, Jovanovic M, Brar GA Cell systems 32710835 Cell Syst 2020 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/32710835
Global translation inhibition yields condition-dependent de-repression of ribosome biogenesis mRNAs. Cheng Z, Brar GA Nucleic acids research 30937450 Nucleic Acids Res 2019 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/30937450
Strategies and Challenges in Identifying Function for Thousands of sORF-Encoded Peptides in Meiosis. Hollerer I, Higdon A, Brar GA Proteomics 28929627 Proteomics 2018 May https://www.ncbi.nlm.nih.gov/pubmed/28929627
Pervasive, Coordinated Protein-Level Changes Driven by Transcript Isoform Switching during Meiosis. Cheng Z, Otto GM, Powers EN, Keskin A, Mertins P, Carr SA, Jovanovic M, Brar GA Cell 29474919 Cell 2018 Feb 22 https://www.ncbi.nlm.nih.gov/pubmed/29474919
Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms. Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA Developmental cell 30016623 Dev Cell 2018 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/30016623
Beyond the Triplet Code: Context Cues Transform Translation. Brar GA Cell 27984720 Cell 2016 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/27984720
Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis. Eisenberg AR, Higdon A, Keskin A, Hodapp S, Jovanovic M, Brar GA Cell reports 30590036 Cell Rep 2018 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/30590036
Global mapping of translation initiation sites by TIS profiling in budding yeast. Hollerer I, Powers EN, Brar GA STAR protocols 33458709 STAR Protoc 2021 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/33458709
Prospects for Engineering Biophysical CO(2) Concentrating Mechanisms into Land Plants to Enhance Yields. Hennacy JH, Jonikas MC Annual review of plant biology 32151155 Annu Rev Plant Biol 2020 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/32151155
Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts. Küken A, Sommer F, Yaneva-Roder L, Mackinder LC, Höhne M, Geimer S, Jonikas MC, Schroda M, Stitt M, Nikoloski Z, Mettler-Altmann T eLife 30306890 Elife 2018 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/30306890
Increasing the uptake of carbon dioxide. Franklin E, Jonikas M eLife 33270556 Elife 2020 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/33270556
Assembly of the algal CO(2)-fixing organelle, the pyrenoid, is guided by a Rubisco-binding motif. Meyer MT, Itakura AK, Patena W, Wang L, He S, Emrich-Mills T, Lau CS, Yates G, Mackinder LCM, Jonikas MC Science advances 33177094 Sci Adv 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/33177094
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Frequency-chirped dynamic nuclear polarization with magic angle spinning using a frequency-agile gyrotron. Gao C, Alaniva N, Saliba EP, Sesti EL, Judge PT, Scott FJ, Halbritter T, Sigurdsson ST, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 31525550 J Magn Reson 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31525550
Electron Decoupling with Dynamic Nuclear Polarization in Rotating Solids. Saliba EP, Sesti EL, Scott FJ, Albert BJ, Choi EJ, Alaniva N, Gao C, Barnes AB Journal of the American Chemical Society 28429936 J Am Chem Soc 2017 May 10 https://www.ncbi.nlm.nih.gov/pubmed/28429936
Frequency-agile gyrotron for electron decoupling and pulsed dynamic nuclear polarization. Scott FJ, Saliba EP, Albert BJ, Alaniva N, Sesti EL, Gao C, Golota NC, Choi EJ, Jagtap AP, Wittmann JJ, Eckardt M, Harneit W, Corzilius B, Th Sigurdsson S, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 29471275 J Magn Reson 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29471275
Dynamic Nuclear Polarization with Electron Decoupling in Intact Human Cells and Cell Lysates. Judge PT, Sesti EL, Price LE, Albert BJ, Alaniva N, Saliba EP, Halbritter T, Sigurdsson ST, Kyei GB, Barnes AB The journal of physical chemistry. B 32083876 J Phys Chem B 2020 Mar 26 https://www.ncbi.nlm.nih.gov/pubmed/32083876
Fast electron paramagnetic resonance magic angle spinning simulations using analytical powder averaging techniques. Saliba EP, Barnes AB The Journal of chemical physics 31542017 J Chem Phys 2019 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/31542017
Electron decoupling with cross polarization and dynamic nuclear polarization below 6 K. Sesti EL, Saliba EP, Alaniva N, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 30077145 J Magn Reson 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30077145
A versatile custom cryostat for dynamic nuclear polarization supports multiple cryogenic magic angle spinning transmission line probes. Scott FJ, Alaniva N, Golota NC, Sesti EL, Saliba EP, Price LE, Albert BJ, Chen P, O'Connor RD, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 30342370 J Magn Reson 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30342370
Sensitivity analysis of magic angle spinning dynamic nuclear polarization below 6 K. Judge PT, Sesti EL, Saliba EP, Alaniva N, Halbritter T, Sigurdsson ST, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 31212198 J Magn Reson 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31212198
Magic angle spinning spheres. Chen P, Albert BJ, Gao C, Alaniva N, Price LE, Scott FJ, Saliba EP, Sesti EL, Judge PT, Fisher EW, Barnes AB Science advances 30255153 Sci Adv 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30255153
Dynamic Nuclear Polarization Nuclear Magnetic Resonance in Human Cells Using Fluorescent Polarizing Agents. Albert BJ, Gao C, Sesti EL, Saliba EP, Alaniva N, Scott FJ, Sigurdsson ST, Barnes AB Biochemistry 29924582 Biochemistry 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/29924582
Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation. Albert BJ, Niu A, Ramani R, Marshall GR, Wender PA, Williams RM, Ratner L, Barnes AB, Kyei GB Scientific reports 28785069 Sci Rep 2017 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/28785069
Pulsed Electron Decoupling and Strategies for Time Domain Dynamic Nuclear Polarization with Magic Angle Spinning. Saliba EP, Sesti EL, Alaniva N, Barnes AB The journal of physical chemistry letters 30180584 J Phys Chem Lett 2018 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/30180584
Characterization of frequency-chirped dynamic nuclear polarization in rotating solids. Judge PT, Sesti EL, Alaniva N, Saliba EP, Price LE, Gao C, Halbritter T, Sigurdsson ST, Kyei GB, Barnes AB Journal of magnetic resonance (San Diego, Calif. : 1997) 32203923 J Magn Reson 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32203923
Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals. Poganik JR, Aye Y Frontiers in aging neuroscience 32116644 Front Aging Neurosci 2020 https://www.ncbi.nlm.nih.gov/pubmed/32116644
Empowering Global Chemical Biology at the Dawn of the New Decade. Hoogendoorn S, Aye Y ACS chemical biology 32315151 ACS Chem Biol 2020 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/32315151
On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry. Long MJ, Poganik JR, Aye Y Journal of the American Chemical Society 26907082 J Am Chem Soc 2016 Mar 23 https://www.ncbi.nlm.nih.gov/pubmed/26907082
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3. Fu Y, Long MJC, Wisitpitthaya S, Inayat H, Pierpont TM, Elsaid IM, Bloom JC, Ortega J, Weiss RS, Aye Y Nature chemical biology 30150681 Nat Chem Biol 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30150681
Weighing up the Selenocysteome Uncovers New Sec-rets. Poganik JR, Aye Y Cell chemical biology 30445052 Cell Chem Biol 2018 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/30445052
T-REX on-demand redox targeting in live cells. Parvez S, Long MJ, Lin HY, Zhao Y, Haegele JA, Pham VN, Lee DK, Aye Y Nature protocols 27809314 Nat Protoc 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27809314
Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor. Surya SL, Long MJC, Urul DA, Zhao Y, Mercer EJ, EIsaid IM, Evans T, Aye Y ACS chemical biology 29397684 ACS Chem Biol 2018 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/29397684
Ube2V2 Is a Rosetta Stone Bridging Redox and Ubiquitin Codes, Coordinating DNA Damage Responses. Zhao Y, Long MJC, Wang Y, Zhang S, Aye Y ACS central science 29532025 ACS Cent Sci 2018 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/29532025
The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor. Poganik JR, Van Hall-Beauvais AK, Long MJC, Disare MT, Zhao Y, Aye Y Helvetica chimica acta 34113045 Helv Chim Acta 2020 May https://www.ncbi.nlm.nih.gov/pubmed/34113045
Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology. Long MJ, Poganik JR, Ghosh S, Aye Y ACS chemical biology 28068059 ACS Chem Biol 2017 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/28068059
β-TrCP1 Is a Vacillatory Regulator of Wnt Signaling. Long MJ, Lin HY, Parvez S, Zhao Y, Poganik JR, Huang P, Aye Y Cell chemical biology 28736239 Cell Chem Biol 2017 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/28736239
Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis. Long MJC, Zhao Y, Aye Y Cell chemical biology 31836351 Cell Chem Biol 2020 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/31836351
The Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making. Long MJC, Aye Y Chemical research in toxicology 27617777 Chem Res Toxicol 2016 Oct 17 https://www.ncbi.nlm.nih.gov/pubmed/27617777
Akt3 is a privileged first responder in isozyme-specific electrophile response. Long MJ, Parvez S, Zhao Y, Surya SL, Wang Y, Zhang S, Aye Y Nature chemical biology 28114274 Nat Chem Biol 2017 Mar https://www.ncbi.nlm.nih.gov/pubmed/28114274
Substoichiometric hydroxynonenylation of a single protein recapitulates whole-cell-stimulated antioxidant response. Parvez S, Fu Y, Li J, Long MJ, Lin HY, Lee DK, Hu GS, Aye Y Journal of the American Chemical Society 25544059 J Am Chem Soc 2015 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/25544059
Getting the Message? Native Reactive Electrophiles Pass Two Out of Three Thresholds to be Bona Fide Signaling Mediators. Poganik JR, Long MJC, Aye Y BioEssays : news and reviews in molecular, cellular and developmental biology 29603288 Bioessays 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29603288
Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery. Long MJC, Hnedzko D, Kim BK, Aye Y Chembiochem : a European journal of chemical biology 30589188 Chembiochem 2019 May 2 https://www.ncbi.nlm.nih.gov/pubmed/30589188
Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling. Long MJC, Wang L, Aye Y Antioxidants & redox signaling 31578876 Antioxid Redox Signal 2020 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/31578876
The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase. Long MJC, Van Hall-Beauvais A, Aye Y Current opinion in chemical biology 31734537 Curr Opin Chem Biol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31734537
A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. Lin HY, Haegele JA, Disare MT, Lin Q, Aye Y Journal of the American Chemical Society 25909755 J Am Chem Soc 2015 May 20 https://www.ncbi.nlm.nih.gov/pubmed/25909755
Single-Protein-Specific Redox Targeting in Live Mammalian Cells and C. elegans. Van Hall-Beauvais A, Zhao Y, Urul DA, Long MJC, Aye Y Current protocols in chemical biology 30085412 Curr Protoc Chem Biol 2018 Sep https://www.ncbi.nlm.nih.gov/pubmed/30085412
REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins. Long MJC, Urul DA, Aye Y Methods in enzymology 32046846 Methods Enzymol 2020 https://www.ncbi.nlm.nih.gov/pubmed/32046846
Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1. Poganik JR, Long MJC, Disare MT, Liu X, Chang SH, Hla T, Aye Y FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31665914 FASEB J 2019 Dec https://www.ncbi.nlm.nih.gov/pubmed/31665914
Genie in a bottle: controlled release helps tame natural polypharmacology? Long MJ, Liu X, Aye Y Current opinion in chemical biology 30913473 Curr Opin Chem Biol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/30913473
Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity. Long MJC, Liu X, Aye Y Frontiers in chemistry 30949469 Front Chem 2019 https://www.ncbi.nlm.nih.gov/pubmed/30949469
Privileged Electrophile Sensors: A Resource for Covalent Drug Development. Long MJC, Aye Y Cell chemical biology 28648380 Cell Chem Biol 2017 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/28648380
Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition. Wisitpitthaya S, Zhao Y, Long MJ, Li M, Fletcher EA, Blessing WA, Weiss RS, Aye Y ACS chemical biology 27159113 ACS Chem Biol 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27159113
Redox Signaling by Reactive Electrophiles and Oxidants. Parvez S, Long MJC, Poganik JR, Aye Y Chemical reviews 30148624 Chem Rev 2018 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/30148624
Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation. Khatri HR, Bhattarai B, Kaplan W, Li Z, Curtis Long MJ, Aye Y, Nagorny P Journal of the American Chemical Society 30802047 J Am Chem Soc 2019 Mar 27 https://www.ncbi.nlm.nih.gov/pubmed/30802047
Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles. Liu X, Long MJC, Aye Y Trends in biochemical sciences 30327250 Trends Biochem Sci 2019 Jan https://www.ncbi.nlm.nih.gov/pubmed/30327250
Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities. Long MJC, Zhao Y, Aye Y RSC chemical biology 34458747 RSC Chem Biol 2020 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/34458747
Distribution shapes govern the discovery of predictive models for gene regulation. Munsky B, Li G, Fox ZR, Shepherd DP, Neuert G Proceedings of the National Academy of Sciences of the United States of America 29959206 Proc Natl Acad Sci U S A 2018 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/29959206
TrueSpot: a robust automated tool for quantifying signal puncta in fluorescent imaging. Hospelhorn BG, Kesler BK, Jashnsaz H, Neuert G Genome biology 41024246 Genome Biol 2025 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/41024246
TrueSpot: A robust automated tool for quantifying signal puncta in fluorescent imaging. Hospelhorn BG, Kesler BK, Jashnsaz H, Neuert G bioRxiv : the preprint server for biology 39868229 bioRxiv 2025 May 21 https://www.ncbi.nlm.nih.gov/pubmed/39868229
Modelling patient drug exposure profiles in vitro to narrow the valley of death. Leasure CS, Neuert G Nature reviews bioengineering 38873361 Nat Rev Bioeng 2024 Mar https://www.ncbi.nlm.nih.gov/pubmed/38873361
Integrating single-molecule experiments and discrete stochastic models to understand heterogeneous gene transcription dynamics. Munsky B, Fox Z, Neuert G Methods (San Diego, Calif.) 26079925 Methods 2015 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/26079925
Diverse Cell Stimulation Kinetics Identify Predictive Signal Transduction Models. Jashnsaz H, Fox ZR, Hughes JJ, Li G, Munsky B, Neuert G iScience 33083733 iScience 2020 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/33083733
Phenotypic consequences of logarithmic signaling in MAPK stress response. Jashnsaz H, Neuert G bioRxiv : the preprint server for biology 38106069 bioRxiv 2023 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/38106069
Automated cell boundary and 3D nuclear segmentation of cells in suspension. Kesler B, Li G, Thiemicke A, Venkat R, Neuert G Scientific reports 31308458 Sci Rep 2019 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/31308458
Finite state projection based bounds to compare chemical master equation models using single-cell data. Fox Z, Neuert G, Munsky B The Journal of chemical physics 27544081 J Chem Phys 2016 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/27544081
From analog to digital models of gene regulation. Munsky B, Neuert G Physical biology 26086470 Phys Biol 2015 Jun 18 https://www.ncbi.nlm.nih.gov/pubmed/26086470
Multiplex RNA single molecule FISH of inducible mRNAs in single yeast cells. Li G, Neuert G Scientific data 31209217 Sci Data 2019 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/31209217
Generating kinetic environments to study dynamic cellular processes in single cells. Thiemicke A, Jashnsaz H, Li G, Neuert G Scientific reports 31300695 Sci Rep 2019 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/31300695
A rate threshold mechanism regulates MAPK stress signaling and survival. Johnson AN, Li G, Jashnsaz H, Thiemicke A, Kesler BK, Rogers DC, Neuert G Proceedings of the National Academy of Sciences of the United States of America 33443180 Proc Natl Acad Sci U S A 2021 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/33443180
Optimal Design of Single-Cell Experiments within Temporally Fluctuating Environments. Fox ZR, Neuert G, Munsky B Complexity 32982137 Complexity 2020 https://www.ncbi.nlm.nih.gov/pubmed/32982137
Kinetics of osmotic stress regulate a cell fate switch of cell survival. Thiemicke A, Neuert G Science advances 33608274 Sci Adv 2021 Feb https://www.ncbi.nlm.nih.gov/pubmed/33608274
Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist-Tsix locus. Kesler BK, Adams J, Neuert G Nature communications 40328749 Nat Commun 2025 May 7 https://www.ncbi.nlm.nih.gov/pubmed/40328749
Rate thresholds in cell signaling have functional and phenotypic consequences in non-linear time-dependent environments. Thiemicke A, Neuert G Frontiers in cell and developmental biology 37025183 Front Cell Dev Biol 2023 https://www.ncbi.nlm.nih.gov/pubmed/37025183
Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL Molecular pharmaceutics 26262434 Mol Pharm 2015 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/26262434
Harnessing Redox Cross-Reactivity To Profile Distinct Cysteine Modifications. Majmudar JD, Konopko AM, Labby KJ, Tom CT, Crellin JE, Prakash A, Martin BR Journal of the American Chemical Society 26780921 J Am Chem Soc 2016 Feb 17 https://www.ncbi.nlm.nih.gov/pubmed/26780921
Variable-Velocity Traveling-Wave Ion Mobility Separation Enhancing Peak Capacity for Data-Independent Acquisition Proteomics. Haynes SE, Polasky DA, Dixit SM, Majmudar JD, Neeson K, Ruotolo BT, Martin BR Analytical chemistry 28471653 Anal Chem 2017 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/28471653
DIA-SIFT: A Precursor and Product Ion Filter for Accurate Stable Isotope Data-Independent Acquisition Proteomics. Haynes SE, Majmudar JD, Martin BR Analytical chemistry 29989796 Anal Chem 2018 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/29989796
Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. Won SJ, Martin BR ACS chemical biology 29733200 ACS Chem Biol 2018 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/29733200
APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells. Hernandez JL, Davda D, Cheung See Kit M, Majmudar JD, Won SJ, Gang M, Pasupuleti SC, Choi AI, Bartkowiak CM, Martin BR Cell chemical biology 28065656 Cell Chem Biol 2017 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/28065656
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). Won SJ, Davda D, Labby KJ, Hwang SY, Pricer R, Majmudar JD, Armacost KA, Rodriguez LA, Rodriguez CL, Chong FS, Torossian KA, Palakurthi J, Hur ES, Meagher JL, Brooks CL 3rd, Stuckey JA, Martin BR ACS chemical biology 27748579 ACS Chem Biol 2016 Dec 16 https://www.ncbi.nlm.nih.gov/pubmed/27748579
Profiling Protein S-Sulfination with Maleimide-Linked Probes. Kuo YH, Konopko AM, Borotto NB, Majmudar JD, Haynes SE, Martin BR Chembiochem : a European journal of chemical biology 28809078 Chembiochem 2017 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/28809078
Targeted Annotation of S-Sulfonylated Peptides by Selective Infrared Multiphoton Dissociation Mass Spectrometry. Borotto NB, McClory PJ, Martin BR, Håkansson K Analytical chemistry 28708386 Anal Chem 2017 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/28708386
Chemoselective ratiometric imaging of protein S-sulfenylation. Tom CTMB, Crellin JE, Motiwala HF, Stone MB, Davda D, Walker W, Kuo YH, Hernandez JL, Labby KJ, Gomez-Rodriguez L, Jenkins PM, Veatch SL, Martin BR Chemical communications (Cambridge, England) 28613292 Chem Commun (Camb) 2017 Jun 29 https://www.ncbi.nlm.nih.gov/pubmed/28613292
HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking. Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA Journal of the American Chemical Society 29035536 J Am Chem Soc 2017 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/29035536
Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly. ElAzzouny M, Tom CT, Evans CR, Olson LL, Tanga MJ, Gallagher KA, Martin BR, Burant CF The Journal of biological chemistry 28188288 J Biol Chem 2017 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/28188288
Activated G Protein Gαs Samples Multiple Endomembrane Compartments. Martin BR, Lambert NA The Journal of biological chemistry 27528603 J Biol Chem 2016 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/27528603
Global Analysis of Palmitoylated Proteins in Toxoplasma gondii. Foe IT, Child MA, Majmudar JD, Krishnamurthy S, van der Linden WA, Ward GE, Martin BR, Bogyo M Cell host & microbe 26468752 Cell Host Microbe 2015 Oct 14 https://www.ncbi.nlm.nih.gov/pubmed/26468752
Free Radical Initiated Peptide Sequencing for Direct Site Localization of Sulfation and Phosphorylation with Negative Ion Mode Mass Spectrometry. Borotto NB, Ileka KM, Tom CATMB, Martin BR, Håkansson K Analytical chemistry 30063332 Anal Chem 2018 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/30063332
Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition. Hernandez JL, Davda D, Majmudar JD, Won SJ, Prakash A, Choi AI, Martin BR Molecular bioSystems 27030425 Mol Biosyst 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27030425
Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2. Won SJ, Eschweiler JD, Majmudar JD, Chong FS, Hwang SY, Ruotolo BT, Martin BR ACS medicinal chemistry letters 28197315 ACS Med Chem Lett 2017 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/28197315
Protein depalmitoylases. Won SJ, Cheung See Kit M, Martin BR Critical reviews in biochemistry and molecular biology 29239216 Crit Rev Biochem Mol Biol 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29239216
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation. Zhao D, Yin Z, Soellner MB, Martin BR Cell chemical biology 33730553 Cell Chem Biol 2021 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/33730553
Enrichment of S-Palmitoylated Proteins for Mass Spectrometry Analysis. Cheung See Kit M, Martin BR Methods in molecular biology (Clifton, N.J.) 31152396 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31152396
Tunable Heteroaromatic Sulfones Enhance in-Cell Cysteine Profiling. Motiwala HF, Kuo YH, Stinger BL, Palfey BA, Martin BR Journal of the American Chemical Society 31881155 J Am Chem Soc 2020 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/31881155
Vesicle Tubulation with Self-Assembling DNA Nanosprings. Grome MW, Zhang Z, Pincet F, Lin C Angewandte Chemie (International ed. in English) 29575478 Angew Chem Int Ed Engl 2018 May 4 https://www.ncbi.nlm.nih.gov/pubmed/29575478
DNA-Origami-Based Fluorescence Brightness Standards for Convenient and Fast Protein Counting in Live Cells. Williams ND, Landajuela A, Kasula RK, Zhou W, Powell JT, Xi Z, Isaacs FJ, Berro J, Toomre D, Karatekin E, Lin C Nano letters 33164530 Nano Lett 2020 Dec 9 https://www.ncbi.nlm.nih.gov/pubmed/33164530
A programmable DNA-origami platform for studying lipid transfer between bilayers. Bian X, Zhang Z, Xiong Q, De Camilli P, Lin C Nature chemical biology 31320758 Nat Chem Biol 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31320758
DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching. Powell JT, Akhuetie-Oni BO, Zhang Z, Lin C Angewandte Chemie (International ed. in English) 27527591 Angew Chem Int Ed Engl 2016 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/27527591
Engineering Lipid Membranes with Programmable DNA Nanostructures. Shen Q, Grome MW, Yang Y, Lin C Advanced biosystems 31934608 Adv Biosyst 2020 Jan https://www.ncbi.nlm.nih.gov/pubmed/31934608
Stiffness and Membrane Anchor Density Modulate DNA-Nanospring-Induced Vesicle Tubulation. Grome MW, Zhang Z, Lin C ACS applied materials & interfaces 31252462 ACS Appl Mater Interfaces 2019 Jul 3 https://www.ncbi.nlm.nih.gov/pubmed/31252462
Placing and shaping liposomes with reconfigurable DNA nanocages. Zhang Z, Yang Y, Pincet F, Llaguno MC, Lin C Nature chemistry 28644472 Nat Chem 2017 Jun 23 https://www.ncbi.nlm.nih.gov/pubmed/28644472
FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. Landajuela A, Braun M, Rodrigues CDA, Martínez-Calvo A, Doan T, Horenkamp F, Andronicos A, Shteyn V, Williams ND, Lin C, Wingreen NS, Rudner DZ, Karatekin E PLoS biology 34185788 PLoS Biol 2021 Jun https://www.ncbi.nlm.nih.gov/pubmed/34185788
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Yang Y, Wu Z, Wang L, Zhou K, Xia K, Xiong Q, Liu L, Zhang Z, Chapman ER, Xiong Y, Melia TJ, Karatekin E, Gu H, Lin C Nature chemistry 33785892 Nat Chem 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33785892
DNA Origami Post-Processing by CRISPR-Cas12a. Xiong Q, Xie C, Zhang Z, Liu L, Powell JT, Shen Q, Lin C Angewandte Chemie (International ed. in English) 31883145 Angew Chem Int Ed Engl 2020 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/31883145
Directing reconfigurable DNA nanoarrays. Yang Y, Lin C Science (New York, N.Y.) 28751594 Science 2017 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/28751594
A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement. Fisher PDE, Shen Q, Akpinar B, Davis LK, Chung KKH, Baddeley D, Šarić A, Melia TJ, Hoogenboom BW, Lin C, Lusk CP ACS nano 29350911 ACS Nano 2018 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/29350911
Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging. Chung KKH, Zhang Z, Kidd P, Zhang Y, Williams ND, Rollins B, Yang Y, Lin C, Baddeley D, Bewersdorf J Nature methods 35501386 Nat Methods 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35501386
DropSynth 2.0: high-fidelity multiplexed gene synthesis in emulsions. Sidore AM, Plesa C, Samson JA, Lubock NB, Kosuri S Nucleic acids research 32692349 Nucleic Acids Res 2020 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/32692349
A multiplexed bacterial two-hybrid for rapid characterization of protein-protein interactions and iterative protein design. Boldridge WC, Ljubetič A, Kim H, Lubock N, Szilágyi D, Lee J, Brodnik A, Jerala R, Kosuri S Nature communications 37532706 Nat Commun 2023 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/37532706
Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross. Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW eLife 33179598 Elife 2020 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/33179598
A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions. Chong R, Insigne KD, Yao D, Burghard CP, Wang J, Hsiao YE, Jones EM, Goodman DB, Xiao X, Kosuri S Molecular cell 30503770 Mol Cell 2019 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/30503770
Systematic Dissection of Sequence Elements Controlling σ70 Promoters Using a Genomically Encoded Multiplexed Reporter Assay in Escherichia coli. Urtecho G, Tripp AD, Insigne KD, Kim H, Kosuri S Biochemistry 29388765 Biochemistry 2019 Mar 19 https://www.ncbi.nlm.nih.gov/pubmed/29388765
A systematic comparison of error correction enzymes by next-generation sequencing. Lubock NB, Zhang D, Sidore AM, Church GM, Kosuri S Nucleic acids research 28911123 Nucleic Acids Res 2017 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/28911123
Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems. Yu TC, Liu WL, Brinck MS, Davis JE, Shek J, Bower G, Einav T, Insigne KD, Phillips R, Kosuri S, Urtecho G Nature communications 33436562 Nat Commun 2021 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/33436562
Multiplexed gene synthesis in emulsions for exploring protein functional landscapes. Plesa C, Sidore AM, Lubock NB, Zhang D, Kosuri S Science (New York, N.Y.) 29301959 Science 2018 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/29301959
Highly parallel genome variant engineering with CRISPR-Cas9. Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L Nature genetics 29632376 Nat Genet 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29632376
Metagenomic mining of regulatory elements enables programmable species-selective gene expression. Johns NI, Gomes ALC, Yim SS, Yang A, Blazejewski T, Smillie CS, Smith MB, Alm EJ, Kosuri S, Wang HH Nature methods 30052624 Nat Methods 2018 May https://www.ncbi.nlm.nih.gov/pubmed/30052624
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Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli. Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM Journal of immunology (Baltimore, Md. : 1950) 28978688 J Immunol 2017 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/28978688
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Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals. Chiaro TR, Greenewood M, Bauer KM, Ost KS, Stephen-Victor E, Murphy M, Weis AM, Nelson MC, Hill JH, Bell R, Voth W, Jackson T, Klag KA, O'Connell RM, Zac Stephens W, Round JL Cell host & microbe 39788099 Cell Host Microbe 2025 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/39788099
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A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round JL Science translational medicine 28275154 Sci Transl Med 2017 Mar 8 https://www.ncbi.nlm.nih.gov/pubmed/28275154
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL Cell host & microbe 30763538 Cell Host Microbe 2019 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/30763538
Using in-cell SHAPE-Seq and simulations to probe structure-function design principles of RNA transcriptional regulators. Takahashi MK, Watters KE, Gasper PM, Abbott TR, Carlson PD, Chen AA, Lucks JB RNA (New York, N.Y.) 27103533 RNA 2016 Jun https://www.ncbi.nlm.nih.gov/pubmed/27103533
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Simultaneous characterization of cellular RNA structure and function with in-cell SHAPE-Seq. Watters KE, Abbott TR, Lucks JB Nucleic acids research 26350218 Nucleic Acids Res 2016 Jan 29 https://www.ncbi.nlm.nih.gov/pubmed/26350218
Mapping RNA Structure In Vitro with SHAPE Chemistry and Next-Generation Sequencing (SHAPE-Seq). Watters KE, Lucks JB Methods in molecular biology (Clifton, N.J.) 27665597 Methods Mol Biol 2016 https://www.ncbi.nlm.nih.gov/pubmed/27665597
Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates. Yu AM, Gasper PM, Cheng L, Lai LB, Kaur S, Gopalan V, Chen AA, Lucks JB Molecular cell 33453165 Mol Cell 2021 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/33453165
DUETT quantitatively identifies known and novel events in nascent RNA structural dynamics from chemical probing data. Xue AY, Yu AM, Lucks JB, Bagheri N Bioinformatics (Oxford, England) 31389563 Bioinformatics 2019 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/31389563
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Characterizing RNA structures in vitro and in vivo with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq). Watters KE, Yu AM, Strobel EJ, Settle AH, Lucks JB Methods (San Diego, Calif.) 27064082 Methods 2016 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/27064082
Cotranscriptional folding of a riboswitch at nucleotide resolution. Watters KE, Strobel EJ, Yu AM, Lis JT, Lucks JB Nature structural & molecular biology 27798597 Nat Struct Mol Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27798597
A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control. Strobel EJ, Cheng L, Berman KE, Carlson PD, Lucks JB Nature chemical biology 31636437 Nat Chem Biol 2019 Nov https://www.ncbi.nlm.nih.gov/pubmed/31636437
Computational design of three-dimensional RNA structure and function. Yesselman JD, Eiler D, Carlson ED, Gotrik MR, d'Aquino AE, Ooms AN, Kladwang W, Carlson PD, Shi X, Costantino DA, Herschlag D, Lucks JB, Jewett MC, Kieft JS, Das R Nature nanotechnology 31427748 Nat Nanotechnol 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31427748
Choosing the right pharmacotherapeutic strategy for HIV maintenance in patients with alcohol addiction. Kodidela S, Kumar S Expert opinion on pharmacotherapy 30724618 Expert Opin Pharmacother 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30724618
Distributed biotin-streptavidin transcription roadblocks for mapping cotranscriptional RNA folding. Strobel EJ, Watters KE, Nedialkov Y, Artsimovitch I, Lucks JB Nucleic acids research 28398514 Nucleic Acids Res 2017 Jul 7 https://www.ncbi.nlm.nih.gov/pubmed/28398514
Characterizing the Structure-Function Relationship of a Naturally Occurring RNA Thermometer. Meyer S, Carlson PD, Lucks JB Biochemistry 29172455 Biochemistry 2017 Dec 26 https://www.ncbi.nlm.nih.gov/pubmed/29172455
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The B. subtilis Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units. Merrikh CN, Brewer BJ, Merrikh H PLoS genetics 26070154 PLoS Genet 2015 Jun https://www.ncbi.nlm.nih.gov/pubmed/26070154
An underlying mechanism for the increased mutagenesis of lagging-strand genes in Bacillus subtilis. Million-Weaver S, Samadpour AN, Moreno-Habel DA, Nugent P, Brittnacher MJ, Weiss E, Hayden HS, Miller SI, Liachko I, Merrikh H Proceedings of the National Academy of Sciences of the United States of America 25713353 Proc Natl Acad Sci U S A 2015 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/25713353
Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis. Lang KS, Hall AN, Merrikh CN, Ragheb M, Tabakh H, Pollock AJ, Woodward JJ, Dreifus JE, Merrikh H Cell 28802046 Cell 2017 Aug 10 https://www.ncbi.nlm.nih.gov/pubmed/28802046
Replication Restart after Replication-Transcription Conflicts Requires RecA in Bacillus subtilis. Million-Weaver S, Samadpour AN, Merrikh H Journal of bacteriology 25939832 J Bacteriol 2015 Jul https://www.ncbi.nlm.nih.gov/pubmed/25939832
The Accelerated Evolution of Lagging Strand Genes Is Independent of Sequence Context. Merrikh CN, Weiss E, Merrikh H Genome biology and evolution 28039230 Genome Biol Evol 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/28039230
Spatial and Temporal Control of Evolution through Replication-Transcription Conflicts. Merrikh H Trends in microbiology 28216294 Trends Microbiol 2017 Jul https://www.ncbi.nlm.nih.gov/pubmed/28216294
The bacterial replisome has factory-like localization. Mangiameli SM, Cass JA, Merrikh H, Wiggins PA Current genetics 29632994 Curr Genet 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/29632994
The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria. Lang KS, Merrikh H Annual review of microbiology 29856930 Annu Rev Microbiol 2018 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/29856930
Inhibiting the Evolution of Antibiotic Resistance. Ragheb MN, Thomason MK, Hsu C, Nugent P, Gage J, Samadpour AN, Kariisa A, Merrikh CN, Miller SI, Sherman DR, Merrikh H Molecular cell 30449724 Mol Cell 2019 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/30449724
Gene inversion potentiates bacterial evolvability and virulence. Merrikh CN, Merrikh H Nature communications 30405125 Nat Commun 2018 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/30405125
Crystal structure of a membrane-bound O-acyltransferase. Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W Nature 30283133 Nature 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30283133
Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts. Lang KS, Merrikh H Cell reports 33657379 Cell Rep 2021 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/33657379
DNA gyrase activity regulates DnaA-dependent replication initiation in Bacillus subtilis. Samadpour AN, Merrikh H Molecular microbiology 29396913 Mol Microbiol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29396913
Structural basis of mitochondrial receptor binding and constriction by DRP1. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A Nature 29899447 Nature 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29899447
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS eLife 29809151 Elife 2018 May 29 https://www.ncbi.nlm.nih.gov/pubmed/29809151
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A Proceedings of the National Academy of Sciences of the United States of America 28242692 Proc Natl Acad Sci U S A 2017 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/28242692
In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE eLife 28718767 Elife 2017 Jul 18 https://www.ncbi.nlm.nih.gov/pubmed/28718767
Structural inhibition of dynamin-mediated membrane fission by endophilin. Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A eLife 28933693 Elife 2017 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/28933693
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N Nature communications 30705304 Nat Commun 2019 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/30705304
Structure and membrane remodeling activity of ESCRT-III helical polymers. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A Science (New York, N.Y.) 26634441 Science 2015 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/26634441
CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS Science (New York, N.Y.) 28751611 Science 2017 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/28751611
Membrane fission by dynamin: what we know and what we need to know. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S The EMBO journal 27670760 EMBO J 2016 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/27670760
Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A Science (New York, N.Y.) 25554787 Science 2015 Jan 2 https://www.ncbi.nlm.nih.gov/pubmed/25554787
Vms1p is a release factor for the ribosome-associated quality control complex. Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J Nature communications 29875445 Nat Commun 2018 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/29875445
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM Proceedings of the National Academy of Sciences of the United States of America 23530241 Proc Natl Acad Sci U S A 2013 Apr 9 https://www.ncbi.nlm.nih.gov/pubmed/23530241
Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases. Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P The Journal of cell biology 31904797 J Cell Biol 2020 Feb 3 https://www.ncbi.nlm.nih.gov/pubmed/31904797
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A Science (New York, N.Y.) 31048491 Science 2019 May 3 https://www.ncbi.nlm.nih.gov/pubmed/31048491
Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM. Carragher B, Cheng Y, Frost A, Glaeser RM, Lander GC, Nogales E, Wang HW Journal of microscopy 31553060 J Microsc 2019 Oct https://www.ncbi.nlm.nih.gov/pubmed/31553060
Structural basis of TRPV1 modulation by endogenous bioactive lipids. Arnold WR, Mancino A, Moss FR 3rd, Frost A, Julius D, Cheng Y Nature structural & molecular biology 38698206 Nat Struct Mol Biol 2024 Sep https://www.ncbi.nlm.nih.gov/pubmed/38698206
Structural and functional studies of membrane remodeling machines. Kalia R, Talledge N, Frost A Methods in cell biology 25997348 Methods Cell Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/25997348
A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ The EMBO journal 27655872 EMBO J 2016 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/27655872
Cell biology: Double agents for mitochondrial division. McBride HM, Frost A Nature 27880759 Nature 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27880759
Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. McCullough J, Frost A, Sundquist WI Annual review of cell and developmental biology 30095293 Annu Rev Cell Dev Biol 2018 Oct 6 https://www.ncbi.nlm.nih.gov/pubmed/30095293
FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK Analytical chemistry 30071717 Anal Chem 2018 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/30071717
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS eLife 33236988 Elife 2020 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/33236988
LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation. von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A Nature 32494070 Nature 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32494070
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P Science (New York, N.Y.) 29599213 Science 2018 Mar 30 https://www.ncbi.nlm.nih.gov/pubmed/29599213
Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M Nature structural & molecular biology 26656853 Nat Struct Mol Biol 2016 Jan https://www.ncbi.nlm.nih.gov/pubmed/26656853
Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. Nguyen HC, Melo AA, Kruk J, Frost A, Gabruk M Nature plants 33875834 Nat Plants 2021 Apr https://www.ncbi.nlm.nih.gov/pubmed/33875834
Membrane constriction and thinning by sequential ESCRT-III polymerization. Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR 3rd, Iwasa JH, Vershinin MD, Sundquist WI, Frost A Nature structural & molecular biology 32251413 Nat Struct Mol Biol 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32251413
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Oxidative guanine base damage regulates human telomerase activity. Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL Nature structural & molecular biology 27820808 Nat Struct Mol Biol 2016 Dec https://www.ncbi.nlm.nih.gov/pubmed/27820808
Single-Cell Imaging Approaches for Studying Small-RNA-Induced Gene Regulation. Koh HR, Myong S Biophysical journal 29970232 Biophys J 2018 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/29970232
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Quantitative analysis and prediction of G-quadruplex forming sequences in double-stranded DNA. Kim M, Kreig A, Lee CY, Rube HT, Calvert J, Song JS, Myong S Nucleic acids research 27095201 Nucleic Acids Res 2016 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/27095201
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Single-molecule real-time detection of telomerase extension activity. Hwang H, Opresko P, Myong S Scientific reports 25263700 Sci Rep 2014 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/25263700
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Molecular mechanism of resolving trinucleotide repeat hairpin by helicases. Qiu Y, Niu H, Vukovic L, Sung P, Myong S Structure (London, England : 1993) 26004439 Structure 2015 Jun 2 https://www.ncbi.nlm.nih.gov/pubmed/26004439
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Chen MC, Tippana R, Demeshkina NA, Murat P, Balasubramanian S, Myong S, Ferré-D'Amaré AR Nature 29899445 Nature 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29899445
Srs2 prevents Rad51 filament formation by repetitive motion on DNA. Qiu Y, Antony E, Doganay S, Koh HR, Lohman TM, Myong S Nature communications 23939144 Nat Commun 2013 https://www.ncbi.nlm.nih.gov/pubmed/23939144
Substrate recognition and specificity of double-stranded RNA binding proteins. Vuković L, Koh HR, Myong S, Schulten K Biochemistry 24801449 Biochemistry 2014 Jun 3 https://www.ncbi.nlm.nih.gov/pubmed/24801449
Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing. Koh HR, Xing L, Kleiman L, Myong S Nucleic acids research 24914047 Nucleic Acids Res 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24914047
G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy. Lee CY, McNerney C, Myong S Methods in molecular biology (Clifton, N.J.) 31444758 Methods Mol Biol 2019 https://www.ncbi.nlm.nih.gov/pubmed/31444758
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. Elbaum-Garfinkle S, Kim Y, Szczepaniak K, Chen CC, Eckmann CR, Myong S, Brangwynne CP Proceedings of the National Academy of Sciences of the United States of America 26015579 Proc Natl Acad Sci U S A 2015 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/26015579
RNA Remodeling Activity of DEAD Box Proteins Tuned by Protein Concentration, RNA Length, and ATP. Kim Y, Myong S Molecular cell 27546789 Mol Cell 2016 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/27546789
RNA Scanning of a Molecular Machine with a Built-in Ruler. Koh HR, Kidwell MA, Doudna J, Myong S Journal of the American Chemical Society 27958730 J Am Chem Soc 2017 Jan 11 https://www.ncbi.nlm.nih.gov/pubmed/27958730
RNA stem structure governs coupling of dicing and gene silencing in RNA interference. Koh HR, Ghanbariniaki A, Myong S Proceedings of the National Academy of Sciences of the United States of America 29133395 Proc Natl Acad Sci U S A 2017 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/29133395
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Visualizing repetitive diffusion activity of double-strand RNA binding proteins by single molecule fluorescence assays. Koh HR, Wang X, Myong S Methods (San Diego, Calif.) 27012177 Methods 2016 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/27012177
mRNA structure determines specificity of a polyQ-driven phase separation. Langdon EM, Qiu Y, Ghanbari Niaki A, McLaughlin GA, Weidmann CA, Gerbich TM, Smith JA, Crutchley JM, Termini CM, Weeks KM, Myong S, Gladfelter AS Science (New York, N.Y.) 29650703 Science 2018 May 25 https://www.ncbi.nlm.nih.gov/pubmed/29650703
The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer. Qiu Y, Levendosky RF, Chakravarthy S, Patel A, Bowman GD, Myong S Molecular cell 28943314 Mol Cell 2017 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/28943314
Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R Cancer research 27503929 Cancer Res 2016 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/27503929
Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens. Patel BB, Lebensohn AM, Pusapati GV, Carette JE, Salzman J, Rohatgi R PloS one 30695034 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/30695034
Phase separation-deficient TDP43 remains functional in splicing. Schmidt HB, Barreau A, Rohatgi R Nature communications 31653829 Nat Commun 2019 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/31653829
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R eLife 31657721 Elife 2019 Oct 30 https://www.ncbi.nlm.nih.gov/pubmed/31657721
TDP-43 α-helical structure tunes liquid-liquid phase separation and function. Conicella AE, Dignon GL, Zerze GH, Schmidt HB, D'Ordine AM, Kim YC, Rohatgi R, Ayala YM, Mittal J, Fawzi NL Proceedings of the National Academy of Sciences of the United States of America 32132204 Proc Natl Acad Sci U S A 2020 Mar 17 https://www.ncbi.nlm.nih.gov/pubmed/32132204
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW EMBO reports 27113758 EMBO Rep 2016 May https://www.ncbi.nlm.nih.gov/pubmed/27113758
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R eLife 27996937 Elife 2016 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/27996937
G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R Science signaling 29438014 Sci Signal 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29438014
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R Developmental cell 29290584 Dev Cell 2018 Jan 8 https://www.ncbi.nlm.nih.gov/pubmed/29290584
Lipid droplets can promote drug accumulation and activation. Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R Nature chemical biology 31932720 Nat Chem Biol 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31932720
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates. Byrne EF, Luchetti G, Rohatgi R, Siebold C Current opinion in cell biology 29268141 Curr Opin Cell Biol 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29268141
Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry. Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R Methods in molecular biology (Clifton, N.J.) 26179043 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26179043
Rapid Screening of Gli2/3 Mutants Using the Flp-In System. Niewiadomski P, Rohatgi R Methods in molecular biology (Clifton, N.J.) 26179044 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26179044
Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG Developmental cell 25936505 Dev Cell 2015 May 26 https://www.ncbi.nlm.nih.gov/pubmed/25936505
High-throughput Flow Cytometry Assay to Investigate TDP43 Splicing Function. Schmidt HB, Rohatgi R Bio-protocol 33659560 Bio Protoc 2020 Apr 20 https://www.ncbi.nlm.nih.gov/pubmed/33659560
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R Developmental cell 29401421 Dev Cell 2018 Jan 22 https://www.ncbi.nlm.nih.gov/pubmed/29401421
R-spondins can potentiate WNT signaling without LGRs. Lebensohn AM, Rohatgi R eLife 29405118 Elife 2018 Feb 6 https://www.ncbi.nlm.nih.gov/pubmed/29405118
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL The EMBO journal 29438978 EMBO J 2018 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/29438978
Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC Nature communications 29712905 Nat Commun 2018 Apr 30 https://www.ncbi.nlm.nih.gov/pubmed/29712905
G-protein-coupled receptors, Hedgehog signaling and primary cilia. Mukhopadhyay S, Rohatgi R Seminars in cell & developmental biology 24845016 Semin Cell Dev Biol 2014 Sep https://www.ncbi.nlm.nih.gov/pubmed/24845016
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Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR. Niewiadomski P, Rohatgi R Methods in molecular biology (Clifton, N.J.) 26179041 Methods Mol Biol 2015 https://www.ncbi.nlm.nih.gov/pubmed/26179041
In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes. Schmidt HB, Rohatgi R Cell reports 27452472 Cell Rep 2016 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/27452472
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T Cell 28086093 Cell 2017 Jan 12 https://www.ncbi.nlm.nih.gov/pubmed/28086093
Photoactivatable protein labeling by singlet oxygen mediated reactions. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X Bioorganic & medicinal chemistry letters 27220724 Bioorg Med Chem Lett 2016 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/27220724
Precision Optogenetic Tool for Selective Single- and Multiple-Cell Ablation in a Live Animal Model System. Makhijani K, To TL, Ruiz-González R, Lafaye C, Royant A, Shu X Cell chemical biology 28065655 Cell Chem Biol 2017 Jan 19 https://www.ncbi.nlm.nih.gov/pubmed/28065655
A rapid fluorogenic GPCR-β-arrestin interaction assay. Zhang Q, Zheng YW, Coughlin SR, Shu X Protein science : a publication of the Protein Society 29411438 Protein Sci 2018 Apr https://www.ncbi.nlm.nih.gov/pubmed/29411438
Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X Molecular cell 29307513 Mol Cell 2018 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/29307513
Singlet oxygen triplet energy transfer-based imaging technology for mapping protein-protein proximity in intact cells. To TL, Fadul MJ, Shu X Nature communications 24905026 Nat Commun 2014 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/24905026
Structure-guided design of a reversible fluorogenic reporter of protein-protein interactions. To TL, Zhang Q, Shu X Protein science : a publication of the Protein Society 26690964 Protein Sci 2016 Mar https://www.ncbi.nlm.nih.gov/pubmed/26690964
Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach. Chung CI, Zhang Q, Shu X Analytical chemistry 30431263 Anal Chem 2018 Dec 18 https://www.ncbi.nlm.nih.gov/pubmed/30431263
Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis. Mo CY, Birdwell LD, Kohli RM Biochemistry 24779472 Biochemistry 2014 May 20 https://www.ncbi.nlm.nih.gov/pubmed/24779472
Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network. Culyba MJ, Kubiak JM, Mo CY, Goulian M, Kohli RM PLoS genetics 29856734 PLoS Genet 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/29856734
Targets for Combating the Evolution of Acquired Antibiotic Resistance. Culyba MJ, Mo CY, Kohli RM Biochemistry 26016604 Biochemistry 2015 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/26016604
Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection. Sungwienwong I, Hostetler ZM, Blizzard RJ, Porter JJ, Driggers CM, Mbengi LZ, Villegas JA, Speight LC, Saven JG, Perona JJ, Kohli RM, Mehl RA, Petersson EJ Organic & biomolecular chemistry 28397914 Org Biomol Chem 2017 May 3 https://www.ncbi.nlm.nih.gov/pubmed/28397914
DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia. Nabel CS, DeNizio JE, Carroll M, Kohli RM Biochemistry 28394581 Biochemistry 2017 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/28394581
Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics. Mo CY, Manning SA, Roggiani M, Culyba MJ, Samuels AN, Sniegowski PD, Goulian M, Kohli RM mSphere 27536734 mSphere 2016 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/27536734
A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage. Kubiak JM, Culyba MJ, Liu MY, Mo CY, Goulian M, Kohli RM ACS synthetic biology 28826208 ACS Synth Biol 2017 Nov 17 https://www.ncbi.nlm.nih.gov/pubmed/28826208
Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership. Mo CY, Culyba MJ, Selwood T, Kubiak JM, Hostetler ZM, Jurewicz AJ, Keller PM, Pope AJ, Quinn A, Schneck J, Widdowson KL, Kohli RM ACS infectious diseases 29275629 ACS Infect Dis 2018 Mar 9 https://www.ncbi.nlm.nih.gov/pubmed/29275629
Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response. Selwood T, Larsen BJ, Mo CY, Culyba MJ, Hostetler ZM, Kohli RM, Reitz AB, Baugh SDP Frontiers in microbiology 30619111 Front Microbiol 2018 https://www.ncbi.nlm.nih.gov/pubmed/30619111
Simple and versatile imaging of genomic loci in live mammalian cells and early pre-implantation embryos using CAS-LiveFISH. Geng Y, Pertsinidis A Scientific reports 34108610 Sci Rep 2021 Jun 9 https://www.ncbi.nlm.nih.gov/pubmed/34108610
A Single-Molecule Surface-Based Platform to Detect the Assembly and Function of the Human RNA Polymerase II Transcription Machinery. Park SR, Hauver J, Zhang Y, Revyakin A, Coleman RA, Tjian R, Chu S, Pertsinidis A Structure (London, England : 1993) 32763141 Structure 2020 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/32763141
Topoisomerase III Acts at the Replication Fork To Remove Precatenanes. Lee CM, Wang G, Pertsinidis A, Marians KJ Journal of bacteriology 30617245 J Bacteriol 2019 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/30617245
Volumetric interferometric lattice light-sheet imaging. Cao B, Coelho S, Li J, Wang G, Pertsinidis A Nature biotechnology 34635835 Nat Biotechnol 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34635835
Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells. Li J, Dong A, Saydaminova K, Chang H, Wang G, Ochiai H, Yamamoto T, Pertsinidis A Cell 31155237 Cell 2019 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/31155237
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Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer. Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, Uddin MM, Ye Y, Yu Z, Liu X, Kamatani Y, Pirruccello JP, Pampana A, Loh PR, Kohli P, McCarroll SA, Neale B, Engels EA, Brown DW, Smoller JW, Green R, Karlson EW, Lebo M, Ellinor PT, Weiss ST, Daly MJ, Biobank Japan Project, FinnGen Consortium, Terao C, Zhao H, Ebert BL, COVID-19 Host Genetics Initiative, Ganna A, Machiela MJ, Genovese G, Natarajan P medRxiv : the preprint server for health sciences 33236019 medRxiv 2020 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/33236019
Chromosomal alterations among age-related haematopoietic clones in Japan. Terao C, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, Matsuda K, Murakami Y, McCarroll SA, Kubo M, Loh PR, Kamatani Y Nature 32581364 Nature 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32581364
Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection. Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat MM, Kentistou K, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman B, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman N, Song L, Gardner EJ, Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ medRxiv : the preprint server for health sciences 36778285 medRxiv 2023 Jan 31 https://www.ncbi.nlm.nih.gov/pubmed/36778285
Repeat polymorphisms underlie top genetic risk loci for glaucoma and colorectal cancer. Mukamel RE, Handsaker RE, Sherman MA, Barton AR, Hujoel MLA, McCarroll SA, Loh PR Cell 37527660 Cell 2023 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/37527660
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions. Maury EA, Sherman MA, Genovese G, Gilgenast TG, Kamath T, Burris SJ, Rajarajan P, Flaherty E, Akbarian S, Chess A, McCarroll SA, Loh PR, Phillips-Cremins JE, Brennand KJ, Macosko EZ, Walters JTR, O'Donovan M, Sullivan P, Psychiatric Genomic Consortium Schizophrenia and CNV workgroup, Brain Somatic Mosaicism Network, Sebat J, Lee EA, Walsh CA Cell genomics 37601975 Cell Genom 2023 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/37601975
A pan-tissue survey of mosaic chromosomal alterations in 948 individuals. Gao T, Kastriti ME, Ljungström V, Heinzel A, Tischler AS, Oberbauer R, Loh PR, Adameyko I, Park PJ, Kharchenko PV Nature genetics 37904053 Nat Genet 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37904053
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Wang X, Shelton SD, Bordieanu B, Frank AR, Yi Y, Venigalla SSK, Gu Z, Lenser NP, Glogauer M, Chandel NS, Zhao H, Zhao Z, McFadden DG, Mishra P Nature aging 35342888 Nat Aging 2022 https://www.ncbi.nlm.nih.gov/pubmed/35342888
Lactate metabolism is essential in early-onset mitochondrial myopathy. Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P Science advances 36598990 Sci Adv 2023 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/36598990
Metabolic inflexibility promotes mitochondrial health during liver regeneration. Wang X, Menezes CJ, Jia Y, Xiao Y, Venigalla SSK, Cai F, Hsieh MH, Gu W, Du L, Sudderth J, Kim D, Shelton SD, Llamas CB, Lin YH, Zhu M, Merchant S, Bezwada D, Kelekar S, Zacharias LG, Mathews TP, Hoxhaj G, Wynn RM, Tambar UK, DeBerardinis RJ, Zhu H, Mishra P Science (New York, N.Y.) 38870309 Science 2024 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/38870309
Differential requirements for mitochondrial electron transport chain components in the adult murine liver. Lesner NP, Wang X, Chen Z, Frank A, Menezes CJ, House S, Shelton SD, Lemoff A, McFadden DG, Wansapura J, DeBerardinis RJ, Mishra P eLife 36154948 Elife 2022 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/36154948
Fusion of dysfunction muscle stem cells with myofibers induces sarcopenia in mice. Wang X, Mishra P bioRxiv : the preprint server for biology 36711602 bioRxiv 2023 Jan 21 https://www.ncbi.nlm.nih.gov/pubmed/36711602
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle. Wang X, Jia Y, Zhao J, Lesner NP, Menezes CJ, Shelton SD, Venigalla SSK, Xu J, Cai C, Mishra P The Journal of clinical investigation 36125902 J Clin Invest 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36125902
Autosomal recessive progeroid syndrome due to homozygosity for a TOMM7 variant. Garg A, Keng WT, Chen Z, Sathe AA, Xing C, Kailasam PD, Shao Y, Lesner NP, Llamas CB, Agarwal AK, Mishra P The Journal of clinical investigation 36282599 J Clin Invest 2022 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/36282599
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis. Shelton SD, House S, Ramesh V, Chen Z, Wei T, Wang X, Llamas CB, Venigalla SSK, Menezes CJ, Zhao Z, Gill JG, DeBerardinis RJ, Morrison SJ, Tasdogan A, Mishra P bioRxiv : the preprint server for biology 37732192 bioRxiv 2023 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/37732192
Measuring renal cortical cell-specific mitochondrial metabolism. Feola K, Venable AH, Rasouli M, Do J, McCoy T, Llamas CB, Straus D, Mishra P, Najafian B, Huen SC bioRxiv : the preprint server for biology 39651228 bioRxiv 2025 Jun 12 https://www.ncbi.nlm.nih.gov/pubmed/39651228
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis. Shelton SD, House S, Martins Nascentes Melo L, Ramesh V, Chen Z, Wei T, Wang X, Llamas CB, Venigalla SSK, Menezes CJ, Allies G, Krystkiewicz J, Rösler J, Meckelmann SW, Zhao P, Rambow F, Schadendorf D, Zhao Z, Gill JG, DeBerardinis RJ, Morrison SJ, Tasdogan A, Mishra P Science advances 39485847 Sci Adv 2024 Nov https://www.ncbi.nlm.nih.gov/pubmed/39485847
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy. Gok MO, Connor OM, Wang X, Menezes CJ, Llamas CB, Mishra P, Friedman JR The Journal of cell biology 36795401 J Cell Biol 2023 Apr 3 https://www.ncbi.nlm.nih.gov/pubmed/36795401
Dynamic and differential renal cortical cell-specific mitochondrial metabolism in response to fasting. Feola K, Venable AH, Rasouli M, Do J, McCoy T, Llamas CB, Straus D, Russell JC, Mishra P, Najafian B, Huen SC American journal of physiology. Renal physiology 41428383 Am J Physiol Renal Physiol 2026 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/41428383
Bioorthogonal Retro-Cope Elimination Reaction of N,N-Dialkylhydroxylamines and Strained Alkynes. Kang D, Kim J Journal of the American Chemical Society 33829777 J Am Chem Soc 2021 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/33829777
Synthesis of push-pull-activated ynol ethers and their evaluation in the bioorthogonal hydroamination reaction. Kang D, Wahl C, Kim J Organic & biomolecular chemistry 36367436 Org Biomol Chem 2022 Nov 30 https://www.ncbi.nlm.nih.gov/pubmed/36367436
Bioorthogonally activated reactive species for target identification. Siriwongsup S, Schmoker AM, Ficarro SB, Marto JA, Kim J Chem 38617077 Chem 2024 Apr 11 https://www.ncbi.nlm.nih.gov/pubmed/38617077
Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents. Kang D, Cheung ST, Wong-Rolle A, Kim J ACS central science 34056093 ACS Cent Sci 2021 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/34056093
Bioorthogonal Click and Release: A General, Rapid, Chemically Revertible Bioconjugation Strategy Employing Enamine N-oxides. Kang D, Lee S, Kim J Chem 36176744 Chem 2022 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/36176744
Enamine N-oxides: Design, Synthesis, and Function in Bioorthogonal Reactions. Kang D, Kim J Synlett : accounts and rapid communications in synthetic organic chemistry 38947226 Synlett 2024 Jan https://www.ncbi.nlm.nih.gov/pubmed/38947226
Bioorthogonal Hydroamination of Push-Pull-Activated Linear Alkynes. Kang D, Cheung ST, Kim J Angewandte Chemie (International ed. in English) 34019705 Angew Chem Int Ed Engl 2021 Jul 26 https://www.ncbi.nlm.nih.gov/pubmed/34019705
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH Cell 30879788 Cell 2019 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/30879788
Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy. Mano T, Albanese A, Dodt HU, Erturk A, Gradinaru V, Treweek JB, Miyawaki A, Chung K, Ueda HR The Journal of neuroscience : the official journal of the Society for Neuroscience 30381424 J Neurosci 2018 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/30381424
Protection of tissue physicochemical properties using polyfunctional crosslinkers. Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K Nature biotechnology 30556815 Nat Biotechnol 2018 Dec 17 https://www.ncbi.nlm.nih.gov/pubmed/30556815
Elasticizing tissues for reversible shape transformation and accelerated molecular labeling. Ku T, Guan W, Evans NB, Sohn CH, Albanese A, Kim JG, Frosch MP, Chung K Nature methods 32424271 Nat Methods 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32424271
Integrated platform for multiscale molecular imaging and phenotyping of the human brain. Park J, Wang J, Guan W, Gjesteby LA, Pollack D, Kamentsky L, Evans NB, Stirman J, Gu X, Zhao C, Marx S, Kim ME, Choi SW, Snyder M, Chavez D, Su-Arcaro C, Tian Y, Park CS, Zhang Q, Yun DH, Moukheiber M, Feng G, Yang XW, Keene CD, Hof PR, Ghosh SS, Frosch MP, Brattain LJ, Chung K Science (New York, N.Y.) 38870291 Science 2024 Jun 14 https://www.ncbi.nlm.nih.gov/pubmed/38870291
Label-free volumetric optical imaging of intact murine brains. Ren J, Choi H, Chung K, Bouma BE Scientific reports 28401897 Sci Rep 2017 Apr 12 https://www.ncbi.nlm.nih.gov/pubmed/28401897
Depolarization signatures map gold nanorods within biological tissue. Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE Nature photonics 29201136 Nat Photonics 2017 https://www.ncbi.nlm.nih.gov/pubmed/29201136
Multiscale 3D phenotyping of human cerebral organoids. Albanese A, Swaney JM, Yun DH, Evans NB, Antonucci JM, Velasco S, Sohn CH, Arlotta P, Gehrke L, Chung K Scientific reports 33293587 Sci Rep 2020 Dec 8 https://www.ncbi.nlm.nih.gov/pubmed/33293587
TISSUE CLEARING. Richardson DS, Guan W, Matsumoto K, Pan C, Chung K, Ertürk A, Ueda HR, Lichtman JW Nature reviews. Methods primers 35128463 Nat Rev Methods Primers 2021 https://www.ncbi.nlm.nih.gov/pubmed/35128463
Tissue clearing and its applications in neuroscience. Ueda HR, Ertürk A, Chung K, Gradinaru V, Chédotal A, Tomancak P, Keller PJ Nature reviews. Neuroscience 31896771 Nat Rev Neurosci 2020 Feb https://www.ncbi.nlm.nih.gov/pubmed/31896771
Self-organized developmental patterning and differentiation in cerebral organoids. Renner M, Lancaster MA, Bian S, Choi H, Ku T, Peer A, Chung K, Knoblich JA The EMBO journal 28283582 EMBO J 2017 May 15 https://www.ncbi.nlm.nih.gov/pubmed/28283582
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues. Ku T, Swaney J, Park JY, Albanese A, Murray E, Cho JH, Park YG, Mangena V, Chen J, Chung K Nature biotechnology 27454740 Nat Biotechnol 2016 Sep https://www.ncbi.nlm.nih.gov/pubmed/27454740
Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation. Weng FJ, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M, Ku T, Zemoura K, Rich D, Garcia-Dominguez D, Hung M, Yelhekar TD, Sørensen AT, Xu W, Chung K, Castillo PE, Lin Y Neuron 29429933 Neuron 2018 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/29429933
Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems. Murray E, Cho JH, Goodwin D, Ku T, Swaney J, Kim SY, Choi H, Park YG, Park JY, Hubbert A, McCue M, Vassallo S, Bakh N, Frosch MP, Wedeen VJ, Seung HS, Chung K Cell 26638076 Cell 2015 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/26638076
Basic principles of hydrogel-based tissue transformation technologies and their applications. Choi SW, Guan W, Chung K Cell 34358468 Cell 2021 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/34358468
Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions. Roy DS, Park YG, Kim ME, Zhang Y, Ogawa SK, DiNapoli N, Gu X, Cho JH, Choi H, Kamentsky L, Martin J, Mosto O, Aida T, Chung K, Tonegawa S Nature communications 35379803 Nat Commun 2022 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/35379803
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN Science translational medicine 28724577 Sci Transl Med 2017 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/28724577
Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives. Andra SS, Austin C, Yang J, Patel D, Arora M The Science of the total environment 27586167 Sci Total Environ 2016 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/27586167
Dynamical properties of elemental metabolism distinguish attention deficit hyperactivity disorder from autism spectrum disorder. Austin C, Curtin P, Curtin A, Gennings C, Arora M, Tammimies K, Isaksson J, Willfors C, Bölte S Translational psychiatry 31551411 Transl Psychiatry 2019 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/31551411
In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort. Cassidy-Bushrow AE, Wu KH, Sitarik AR, Park SK, Bielak LF, Austin C, Gennings C, Curtin P, Johnson CC, Arora M Environmental research 30735952 Environ Res 2019 Apr https://www.ncbi.nlm.nih.gov/pubmed/30735952
Bayesian varying coefficient kernel machine regression to assess neurodevelopmental trajectories associated with exposure to complex mixtures. Liu SH, Bobb JF, Claus Henn B, Gennings C, Schnaas L, Tellez-Rojo M, Bellinger D, Arora M, Wright RO, Coull BA Statistics in medicine 30277584 Stat Med 2018 Dec 30 https://www.ncbi.nlm.nih.gov/pubmed/30277584
Recurrence quantification analysis to characterize cyclical components of environmental elemental exposures during fetal and postnatal development. Curtin P, Curtin A, Austin C, Gennings C, Tammimies K, Bölte S, Arora M PloS one 29112980 PLoS One 2017 https://www.ncbi.nlm.nih.gov/pubmed/29112980
Uncovering neurodevelopmental windows of susceptibility to manganese exposure using dentine microspatial analyses. Claus Henn B, Austin C, Coull BA, Schnaas L, Gennings C, Horton MK, Hernández-Ávila M, Hu H, Téllez-Rojo MM, Wright RO, Arora M Environmental research 29247915 Environ Res 2018 Feb https://www.ncbi.nlm.nih.gov/pubmed/29247915
Exposure to environmental chemical mixtures is associated with nasal colonization by Staphylococcus aureus: NHANES 2001-2004. Eggers S, Gennings C, Malecki KMC, Safdar N, Arora M Environmental research 32771801 Environ Res 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32771801
Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis. Curtin P, Austin C, Curtin A, Gennings C, Figueroa-Romero C, Mikhail KA, Botero TM, Goutman SA, Feldman EL, Arora M PLoS computational biology 32294079 PLoS Comput Biol 2020 Apr https://www.ncbi.nlm.nih.gov/pubmed/32294079
Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities. Andra SS, Austin C, Arora M Environmental research 26219084 Environ Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26219084
Manganese in teeth and neurodevelopment in young Mexican-American children. Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B Environmental research 26381693 Environ Res 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26381693
The tooth exposome in children's health research. Andra SS, Austin C, Arora M Current opinion in pediatrics 26859286 Curr Opin Pediatr 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26859286
Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Austin C, Smith TM, Farahani RM, Hinde K, Carter EA, Lee J, Lay PA, Kennedy BJ, Sarrafpour B, Wright RJ, Wright RO, Arora M Scientific reports 26727334 Sci Rep 2016 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/26727334
A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers. Niedzwiecki MM, Austin C, Remark R, Merad M, Gnjatic S, Estrada-Gutierrez G, Espejel-Nuñez A, Borboa-Olivares H, Guzman-Huerta M, Wright RJ, Wright RO, Arora M Metallomics : integrated biometal science 26987553 Metallomics 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26987553
Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry. Bauer JA, White RF, Coull BA, Austin C, Oppini M, Zoni S, Fedrighi C, Cagna G, Placidi D, Guazzetti S, Yang Q, Bellinger DC, Webster TF, Wright RO, Smith D, Horton M, Lucchini RG, Arora M, Claus Henn B Neurotoxicology 34478771 Neurotoxicology 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/34478771
Multielemental bioimaging of tissues in children's environmental health research. Austinc C, Niedzwiecki MM, Arora M Current opinion in pediatrics 26845145 Curr Opin Pediatr 2016 Apr https://www.ncbi.nlm.nih.gov/pubmed/26845145
Cyclical nursing patterns in wild orangutans. Smith TM, Austin C, Hinde K, Vogel ER, Arora M Science advances 28560319 Sci Adv 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28560319
Fetal and postnatal metal dysregulation in autism. Arora M, Reichenberg A, Willfors C, Austin C, Gennings C, Berggren S, Lichtenstein P, Anckarsäter H, Tammimies K, Bölte S Nature communications 28569757 Nat Commun 2017 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/28569757
Burden of higher lead exposure in African-Americans starts in utero and persists into childhood. Cassidy-Bushrow AE, Sitarik AR, Havstad S, Park SK, Bielak LF, Austin C, Johnson CC, Arora M Environment international 28886415 Environ Int 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28886415
Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth. Wahlberg K, Arora M, Curtin A, Curtin P, Wright RO, Smith DR, Lucchini RG, Broberg K, Austin C Neurotoxicology 28917719 Neurotoxicology 2018 Jan https://www.ncbi.nlm.nih.gov/pubmed/28917719
Environmental exposures and pediatric kidney function and disease: A systematic review. Zheng LY, Sanders AP, Saland JM, Wright RO, Arora M Environmental research 28727988 Environ Res 2017 Oct https://www.ncbi.nlm.nih.gov/pubmed/28727988
Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures. Liu SH, Bobb JF, Lee KH, Gennings C, Claus Henn B, Bellinger D, Austin C, Schnaas L, Tellez-Rojo MM, Hu H, Wright RO, Arora M, Coull BA Biostatistics (Oxford, England) 28968676 Biostatistics 2018 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/28968676
Tooth-Matrix Biomarkers to Reconstruct Critical Periods of Brain Plasticity. Morishita H, Arora M Trends in neurosciences 28038829 Trends Neurosci 2017 Jan https://www.ncbi.nlm.nih.gov/pubmed/28038829
Near-Infrared Intraoperative Chemiluminescence Imaging. Büchel GE, Carney B, Shaffer TM, Tang J, Austin C, Arora M, Zeglis BM, Grimm J, Eppinger J, Reiner T ChemMedChem 27471800 ChemMedChem 2016 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/27471800
Tooth manganese as a biomarker of exposure and body burden in rats. Austin C, Richardson C, Smith D, Arora M Environmental research 28279842 Environ Res 2017 May https://www.ncbi.nlm.nih.gov/pubmed/28279842
Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice. Morris-Schaffer K, Sobolewski M, Allen JL, Marvin E, Yee M, Arora M, O'Reilly MA, Cory-Slechta DA Neurotoxicology 29920326 Neurotoxicology 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29920326
Manganese transporter genetics and sex modify the association between environmental manganese exposure and neurobehavioral outcomes in children. Broberg K, Taj T, Guazzetti S, Peli M, Cagna G, Pineda D, Placidi D, Wright RO, Smith DR, Lucchini RG, Wahlberg K Environment international 31233999 Environ Int 2019 Sep https://www.ncbi.nlm.nih.gov/pubmed/31233999
Modeling the health effects of time-varying complex environmental mixtures: Mean field variational Bayes for lagged kernel machine regression. Liu SH, Bobb JF, Claus Henn B, Schnaas L, Tellez-Rojo MM, Gennings C, Arora M, Wright RO, Coull BA, Wand MP Environmetrics 30686915 Environmetrics 2018 Jun https://www.ncbi.nlm.nih.gov/pubmed/30686915
Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior. Horton MK, Hsu L, Claus Henn B, Margolis A, Austin C, Svensson K, Schnaas L, Gennings C, Hu H, Wright R, Rojo MMT, Arora M Environment international 30205321 Environ Int 2018 Dec https://www.ncbi.nlm.nih.gov/pubmed/30205321
Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernández-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B Environment international 26209874 Environ Int 2015 Nov https://www.ncbi.nlm.nih.gov/pubmed/26209874
Is poor oral health a risk marker for incident cardiovascular disease hospitalisation and all-cause mortality? Findings from 172 630 participants from the prospective 45 and Up Study. Joshy G, Arora M, Korda RJ, Chalmers J, Banks E BMJ open 27577588 BMJ Open 2016 Aug 30 https://www.ncbi.nlm.nih.gov/pubmed/27577588
Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents. Chiu YM, Claus Henn B, Hsu HL, Pendo MP, Coull BA, Austin C, Cagna G, Fedrighi C, Placidi D, Smith DR, Wright RO, Lucchini RG, Arora M Environmental research 28858760 Environ Res 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28858760
Manganese in teeth and neurobehavior: Sex-specific windows of susceptibility. Bauer JA, Claus Henn B, Austin C, Zoni S, Fedrighi C, Cagna G, Placidi D, White RF, Yang Q, Coull BA, Smith D, Lucchini RG, Wright RO, Arora M Environment international 28941415 Environ Int 2017 Nov https://www.ncbi.nlm.nih.gov/pubmed/28941415
New Research Strategy for Measuring Pre- and Postnatal Metal Dysregulation in Psychotic Disorders. Velthorst E, Smith L, Bello G, Austin C, Gennings C, Modabbernia A, Franke N, Frangou S, Wright R, de Haan L, Reichenberg A, Arora M Schizophrenia bulletin 28981868 Schizophr Bull 2017 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/28981868
Early-life dentine manganese concentrations and intrinsic functional brain connectivity in adolescents: A pilot study. de Water E, Papazaharias DM, Ambrosi C, Mascaro L, Iannilli E, Gasparotti R, Lucchini RG, Austin C, Arora M, Tang CY, Smith DR, Wright RO, Horton MK PloS one 31412061 PLoS One 2019 https://www.ncbi.nlm.nih.gov/pubmed/31412061
Elemental signatures of Australopithecus africanus teeth reveal seasonal dietary stress. Joannes-Boyau R, Adams JW, Austin C, Arora M, Moffat I, Herries AIR, Tonge MP, Benazzi S, Evans AR, Kullmer O, Wroe S, Dosseto A, Fiorenza L Nature 31308534 Nature 2019 Aug https://www.ncbi.nlm.nih.gov/pubmed/31308534
Cross-sectional study of the association between serum perfluorinated alkyl acid concentrations and dental caries among US adolescents (NHANES 1999-2012). Puttige Ramesh N, Arora M, Braun JM BMJ open 30782897 BMJ Open 2019 Feb 19 https://www.ncbi.nlm.nih.gov/pubmed/30782897
Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Curtin P, Austin C, Curtin A, Gennings C, Arora M, (for the Emergent Dynamical Systems Group), Tammimies K, Willfors C, Berggren S, Siper P, Rai D, Meyering K, Kolevzon A, Mollon J, David AS, Lewis G, Zammit S, Heilbrun L, Palmer RF, Wright RO, Bölte S, Reichenberg A Science advances 29854952 Sci Adv 2018 May https://www.ncbi.nlm.nih.gov/pubmed/29854952
Stress exposure histories revealed by biochemical changes along accentuated lines in teeth. Austin C, Kumar P, Carter EA, Lee J, Smith TM, Hinde K, Arora M, Lay PA Chemosphere 37054846 Chemosphere 2023 Jul https://www.ncbi.nlm.nih.gov/pubmed/37054846
Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome. Andra SS, Austin C, Wright RO, Arora M Environment international 26134987 Environ Int 2015 Oct https://www.ncbi.nlm.nih.gov/pubmed/26134987
Wintertime stress, nursing, and lead exposure in Neanderthal children. Smith TM, Austin C, Green DR, Joannes-Boyau R, Bailey S, Dumitriu D, Fallon S, Grün R, James HF, Moncel MH, Williams IS, Wood R, Arora M Science advances 30402544 Sci Adv 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/30402544
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Reciprocal Signaling between Myeloid Derived Suppressor and Tumor Cells Enhances Cellular Motility and is Mediated by Structural Cues in the Microenvironment. Shukla VC, Duarte-Sanmiguel S, Panic A, Senthilvelan A, Moore J, Bobba C, Benner B, Carson WE 3rd, Ghadiali SN, Gallego-Perez D Advanced biosystems 32419350 Adv Biosyst 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32419350
Designer Extracellular Vesicles Modulate Pro-Neuronal Cell Responses and Improve Intracranial Retention. Ortega-Pineda L, Sunyecz A, Salazar-Puerta AI, Rincon-Benavides MA, Alzate-Correa D, Anaparthi AL, Guilfoyle E, Mezache L, Struckman HL, Duarte-Sanmiguel S, Deng B, McComb DW, Dodd DJ, Lawrence WR, Moore J, Zhang J, Reátegui E, Veeraraghavan R, Nelson MT, Gallego-Perez D, Higuita-Castro N Advanced healthcare materials 35014204 Adv Healthc Mater 2022 Mar https://www.ncbi.nlm.nih.gov/pubmed/35014204
Nanotransfection-based vasculogenic cell reprogramming drives functional recovery in a mouse model of ischemic stroke. Lemmerman LR, Balch MHH, Moore JT, Alzate-Correa D, Rincon-Benavides MA, Salazar-Puerta A, Gnyawali S, Harris HN, Lawrence W, Ortega-Pineda L, Wilch L, Risser IB, Maxwell AJ, Duarte-Sanmiguel S, Dodd D, Guio-Vega GP, McTigue DM, Arnold WD, Nimjee SM, Sen CK, Khanna S, Rink C, Higuita-Castro N, Gallego-Perez D Science advances 33741587 Sci Adv 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33741587
Injectable pulverized electrospun poly(lactic-co-glycolic acid) fibers improve human adipose tissue engraftment and volume retention. Das D, Lawrence WR, Diaz-Starokozheva L, Salazar-Puerta AI, Ott N, Goebel ER, Damughatla A, Vidal P, Gallentine S, Moore JT, Kayuha D, Mendonca NC, Albert JB, Houser R, Johnson J, Powell H, Higuita-Castro N, Stanford KI, Gallego-Perez D Journal of biomedical materials research. Part A 37326365 J Biomed Mater Res A 2023 Nov https://www.ncbi.nlm.nih.gov/pubmed/37326365
Engineered Extracellular Vesicle-Based Therapies for Valvular Heart Disease. Salazar-Puerta AI, Kordowski M, Cuellar-Gaviria TZ, Rincon-Benavides MA, Hussein J, Flemister D, Mayoral-Andrade G, Barringer G, Guilfoyle E, Blackstone BN, Deng B, Zepeda-Orozco D, McComb DW, Powell H, Dasi LP, Gallego-Perez D, Higuita-Castro N Cellular and molecular bioengineering 37810997 Cell Mol Bioeng 2023 Aug https://www.ncbi.nlm.nih.gov/pubmed/37810997
Engineered Vasculogenic Extracellular Vesicles Drive Nonviral Direct Conversions of Human Dermal Fibroblasts into Induced Endothelial Cells and Improve Wound Closure. Rincon-Benavides MA, Mendonca NC, Cuellar-Gaviria TZ, Salazar-Puerta AI, Ortega-Pineda L, Blackstone BN, Deng B, McComb DW, Gallego-Perez D, Powell HM, Higuita-Castro N Advanced therapeutics 37577183 Adv Ther (Weinh) 2023 Mar https://www.ncbi.nlm.nih.gov/pubmed/37577183
Engineered extracellular vesicles from human skin cells induce pro-β-cell conversions in pancreatic ductal cells. Ortega-Pineda L, Guilfoyle E, Rincon-Benavides MA, Anaparthi AL, Lemmerman LR, Cuellar-Gaviria TZ, Lawrence W, Buss JL, Deng B, Blackstone BN, Salazar-Puerta A, McComb DW, Powell H, Gallego-Perez D, Higuita-Castro N Advanced nanobiomed research 38911285 Adv Nanobiomed Res 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/38911285
Tissue nano-transfection of antimicrobial genes drives bacterial biofilm killing in wounds and is potentially mediated by extracellular vesicles. Cuellar-Gaviria TZ, Rincon-Benavides MA, Halipci Topsakal HN, Salazar-Puerta AI, Jaramillo-Garrido S, Kordowski M, Vasquez-Martinez CA, Nguyen KT, Rima XY, Rana PSJB, Combita-Heredia O, Deng B, Dathathreya K, McComb DW, Reategui E, Wozniak D, Higuita-Castro N, Gallego-Perez D Journal of controlled release : official journal of the Controlled Release Society 39491627 J Control Release 2024 Dec https://www.ncbi.nlm.nih.gov/pubmed/39491627
The Fifth Annual Symposium of the Midwest Aging Consortium. Reader BF, Rosas L, Knopf BA, Liu Y, Alzate-Correa D, Bhat A, Carey A, Cuervo AM, Dayal S, Demarco RS, Elliehausen CJ, Englund DA, Hamilton HL, Johnston M, Kang P, Konopka AR, Lepola N, Presley CJ, Schafer MJ, Serrano J, Singer BD, Song MA, Stanford KI, Taylor J, Wei W, Yeh CY, Zhang L, Zhang L, Anderson RM, Bai H, Robbins PD, Lamming DW, Mihaylova MM, Rojas M, Mora AL The journals of gerontology. Series A, Biological sciences and medical sciences 39704343 J Gerontol A Biol Sci Med Sci 2025 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/39704343
Early Intervention in Ischemic Tissue with Oxygen Nanocarriers Enables Successful Implementation of Restorative Cell Therapies. Diaz-Starokozheva L, Das D, Gu X, Moore JT, Lemmerman LR, Valerio I, Powell HM, Higuita-Castro N, Go MR, Palmer AF, Gallego-Perez D Cellular and molecular bioengineering 33184576 Cell Mol Bioeng 2020 Oct https://www.ncbi.nlm.nih.gov/pubmed/33184576
ICAM-1-decorated extracellular vesicles loaded with miR-146a and Glut1 drive immunomodulation and hinder tumor progression in a murine model of breast cancer. Duarte-Sanmiguel S, Salazar-Puerta AI, Panic A, Dodd D, Francis C, Alzate-Correa D, Ortega-Pineda L, Lemmerman L, Rincon-Benavides MA, Dathathreya K, Lawrence W, Ott N, Zhang J, Deng B, Wang S, Santander SP, McComb DW, Reategui E, Palmer AF, Carson WE, Higuita-Castro N, Gallego-Perez D Biomaterials science 37646133 Biomater Sci 2023 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/37646133
Nanochannel-Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue. Moore JT, Wier CG, Lemmerman LR, Ortega-Pineda L, Dodd DJ, Lawrence WR, Duarte-Sanmiguel S, Dathathreya K, Diaz-Starokozheva L, Harris HN, Sen CK, Valerio IL, Higuita-Castro N, Arnold WD, Kolb SJ, Gallego-Perez D Advanced biosystems 32939985 Adv Biosyst 2020 Nov https://www.ncbi.nlm.nih.gov/pubmed/32939985
Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment. Lemmerman LR, Das D, Higuita-Castro N, Mirmira RG, Gallego-Perez D Trends in endocrinology and metabolism: TEM 32396845 Trends Endocrinol Metab 2020 Jun https://www.ncbi.nlm.nih.gov/pubmed/32396845
Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing. Gold K, Gaharwar AK, Jain A Biomaterials 30072038 Biomaterials 2019 Mar https://www.ncbi.nlm.nih.gov/pubmed/30072038
Two-dimensional metal organic frameworks for biomedical applications. Arun Kumar S, Balasubramaniam B, Bhunia S, Jaiswal MK, Verma K, Prateek, Khademhosseini A, Gupta RK, Gaharwar AK Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 33137846 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021 Mar https://www.ncbi.nlm.nih.gov/pubmed/33137846
Polymer-Coated Extracellular Vesicles for Selective Codelivery of Chemotherapeutics and siRNA to Cancer Cells. Jhan YY, Palou Zuniga G, Singh KA, Gaharwar AK, Alge DL, Bishop CJ ACS applied bio materials 35014481 ACS Appl Bio Mater 2021 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/35014481
Correction: Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion. Jaiswal MK, Singh KA, Lokhande G, Gaharwar AK Chemical communications (Cambridge, England) 40815125 Chem Commun (Camb) 2025 Aug 26 https://www.ncbi.nlm.nih.gov/pubmed/40815125
Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program. Brokesh AM, Cross LM, Kersey AL, Murali A, Richter C, Gregory CA, Singh I, Gaharwar AK Science advances 35476448 Sci Adv 2022 Apr 29 https://www.ncbi.nlm.nih.gov/pubmed/35476448
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs. Kersey AL, Cheng DY, Deo KA, Dubell CR, Wang TC, Jaiswal MK, Kim MH, Murali A, Hargett SE, Mallick S, Lele TP, Singh I, Gaharwar AK Biomaterials 38335719 Biomaterials 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38335719
Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis. Singh KA, Soukar J, Zulkifli M, Kersey A, Lokhande G, Ghosh S, Murali A, Garza NM, Kaur H, Keeney JN, Banavath R, Ceylan Koydemir H, Sitcheran R, Singh I, Gohil VM, Gaharwar AK Nature communications 39289340 Nat Commun 2024 Sep 17 https://www.ncbi.nlm.nih.gov/pubmed/39289340
Granular Biphasic Colloidal Hydrogels for 3D Bioprinting. Deo KA, Murali A, Tronolone JJ, Mandrona C, Lee HP, Rajput S, Hargett SE, Selahi A, Sun Y, Alge DL, Jain A, Gaharwar AK Advanced healthcare materials 38749006 Adv Healthc Mater 2024 Oct https://www.ncbi.nlm.nih.gov/pubmed/38749006
Nanoengineered Colloidal Inks for 3D Bioprinting. Peak CW, Stein J, Gold KA, Gaharwar AK Langmuir : the ACS journal of surfaces and colloids 28981287 Langmuir 2018 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/28981287
Self-assembled, ellipsoidal polymeric nanoparticles for intracellular delivery of therapeutics. Desai P, Venkataramanan A, Schneider R, Jaiswal MK, Carrow JK, Purwada A, Singh A, Gaharwar AK Journal of biomedical materials research. Part A 29577576 J Biomed Mater Res A 2018 Jul https://www.ncbi.nlm.nih.gov/pubmed/29577576
Effect of ionic strength on shear-thinning nanoclay-polymer composite hydrogels. Sheikhi A , Afewerki S , Oklu R , Gaharwar AK , Khademhosseini A Biomaterials science 29944151 Biomater Sci 2018 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/29944151
Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue. Chimene D, Miller L, Cross LM, Jaiswal MK, Singh I, Gaharwar AK ACS applied materials & interfaces 32091189 ACS Appl Mater Interfaces 2020 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/32091189
2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells. Bhunia S, Jaiswal MK, Singh KA, Deo KA, Gaharwar AK Advanced healthcare materials 35104392 Adv Healthc Mater 2022 May https://www.ncbi.nlm.nih.gov/pubmed/35104392
Light-Responsive Inorganic Biomaterials for Biomedical Applications. Lee HP, Gaharwar AK Advanced science (Weinheim, Baden-Wurttemberg, Germany) 32995121 Adv Sci (Weinh) 2020 Sep https://www.ncbi.nlm.nih.gov/pubmed/32995121
Superhydrophobic states of 2D nanomaterials controlled by atomic defects can modulate cell adhesion. Jaiswal MK , Singh KA , Lokhande G , Gaharwar AK Chemical communications (Cambridge, England) 31172998 Chem Commun (Camb) 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31172998
3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering. Carrow JK, Di Luca A, Dolatshahi-Pirouz A, Moroni L, Gaharwar AK Regenerative biomaterials 30740240 Regen Biomater 2019 Feb https://www.ncbi.nlm.nih.gov/pubmed/30740240
Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery. Lee HP, Davis R Jr, Wang TC, Deo KA, Cai KX, Alge DL, Lele TP, Gaharwar AK ACS applied bio materials 37584641 ACS Appl Bio Mater 2023 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/37584641
Organelle-Targeting Nanoparticles. Soukar J, Peppas NA, Gaharwar AK Advanced science (Weinheim, Baden-Wurttemberg, Germany) 39806939 Adv Sci (Weinh) 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/39806939
Inorganic ions activate lineage-specific gene regulatory networks. Kersey AL, Singh I, Gaharwar AK Acta biomaterialia 38552761 Acta Biomater 2024 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/38552761
Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation. Murali A, Brokesh AM, Cross LM, Kersey AL, Jaiswal MK, Singh I, Gaharwar A Advanced science (Weinheim, Baden-Wurttemberg, Germany) 38738803 Adv Sci (Weinh) 2024 Aug https://www.ncbi.nlm.nih.gov/pubmed/38738803
Shear-Thinning and Thermo-Reversible Nanoengineered Inks for 3D Bioprinting. Wilson SA, Cross LM, Peak CW, Gaharwar AK ACS applied materials & interfaces 29214803 ACS Appl Mater Interfaces 2017 Dec 20 https://www.ncbi.nlm.nih.gov/pubmed/29214803
Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting. Xin S, Deo KA, Dai J, Pandian NKR, Chimene D, Moebius RM, Jain A, Han A, Gaharwar AK, Alge DL Science advances 34652944 Sci Adv 2021 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/34652944
Emerging 2D Nanomaterials for Biomedical Applications. Murali A, Lokhande G, Deo KA, Brokesh A, Gaharwar AK Materials today (Kidlington, England) 34970073 Mater Today (Kidlington) 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34970073
3D Bioprinted Multicellular Vascular Models. Gold KA, Saha B, Rajeeva Pandian NK, Walther BK, Palma JA, Jo J, Cooke JP, Jain A, Gaharwar AK Advanced healthcare materials 34310082 Adv Healthc Mater 2021 Nov https://www.ncbi.nlm.nih.gov/pubmed/34310082
Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders. Erezuma I, Eufrasio-da-Silva T, Golafshan N, Deo K, Mishra YK, Castilho M, Gaharwar AK, Leeuwenburgh S, Dolatshahi-Pirouz A, Orive G Advanced healthcare materials 34185438 Adv Healthc Mater 2021 Aug https://www.ncbi.nlm.nih.gov/pubmed/34185438
Conditioning of 3D Printed Nanoengineered Ionic-Covalent Entanglement Scaffolds with iP-hMSCs Derived Matrix. Sears C, Mondragon E, Richards ZI, Sears N, Chimene D, McNeill EP, Gregory CA, Gaharwar AK, Kaunas R Advanced healthcare materials 32147960 Adv Healthc Mater 2020 Aug https://www.ncbi.nlm.nih.gov/pubmed/32147960
Printing Therapeutic Proteins in 3D using Nanoengineered Bioink to Control and Direct Cell Migration. Peak CW, Singh KA, Adlouni M, Chen J, Gaharwar AK Advanced healthcare materials 31066517 Adv Healthc Mater 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/31066517
Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting. Xin S , Chimene D , Garza JE , Gaharwar AK , Alge DL Biomaterials science 30656307 Biomater Sci 2019 Feb 26 https://www.ncbi.nlm.nih.gov/pubmed/30656307
2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing. Gaharwar AK, Cross LM, Peak CW, Gold K, Carrow JK, Brokesh A, Singh KA Advanced materials (Deerfield Beach, Fla.) 30941811 Adv Mater 2019 Jun https://www.ncbi.nlm.nih.gov/pubmed/30941811
Nano-bio interactions of 2D molybdenum disulfide. Roy S, Deo KA, Singh KA, Lee HP, Jaiswal A, Gaharwar AK Advanced drug delivery reviews 35636569 Adv Drug Deliv Rev 2022 Aug https://www.ncbi.nlm.nih.gov/pubmed/35636569
Nanoengineered Ink for Designing 3D Printable Flexible Bioelectronics. Deo KA, Jaiswal MK, Abasi S, Lokhande G, Bhunia S, Nguyen TU, Namkoong M, Darvesh K, Guiseppi-Elie A, Tian L, Gaharwar AK ACS nano 35675588 ACS Nano 2022 Jun 28 https://www.ncbi.nlm.nih.gov/pubmed/35675588
Nanobio Interface Between Proteins and 2D Nanomaterials. Roy S, Aastha, Deo KA, Dey K, Gaharwar AK, Jaiswal A ACS applied materials & interfaces 37487195 ACS Appl Mater Interfaces 2023 Aug 2 https://www.ncbi.nlm.nih.gov/pubmed/37487195
Gradient nanocomposite hydrogels for interface tissue engineering. Cross LM, Shah K, Palani S, Peak CW, Gaharwar AK Nanomedicine : nanotechnology, biology, and medicine 28554596 Nanomedicine 2018 Oct https://www.ncbi.nlm.nih.gov/pubmed/28554596
2D layered nanomaterials for therapeutics delivery. Davis R Jr, Urbanowski RA Jr, Gaharwar AK Current opinion in biomedical engineering 35814330 Curr Opin Biomed Eng 2021 Dec https://www.ncbi.nlm.nih.gov/pubmed/35814330
Comparison of Photo Cross Linkable Gelatin Derivatives and Initiators for Three-Dimensional Extrusion Bioprinting. Tigner TJ, Rajput S, Gaharwar AK, Alge DL Biomacromolecules 31743018 Biomacromolecules 2020 Feb 10 https://www.ncbi.nlm.nih.gov/pubmed/31743018
Photothermal modulation of human stem cells using light-responsive 2D nanomaterials. Carrow JK, Singh KA, Jaiswal MK, Ramirez A, Lokhande G, Yeh AT, Sarkar TR, Singh I, Gaharwar AK Proceedings of the National Academy of Sciences of the United States of America 32461372 Proc Natl Acad Sci U S A 2020 Jun 16 https://www.ncbi.nlm.nih.gov/pubmed/32461372
Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates. Cross LM, Carrow JK, Ding X, Singh KA, Gaharwar AK ACS applied materials & interfaces 30676016 ACS Appl Mater Interfaces 2019 Feb 20 https://www.ncbi.nlm.nih.gov/pubmed/30676016
Dynamically crosslinked thermoresponsive granular hydrogels. Lee HP, Cai KX, Wang TC, Davis R Jr, Deo K, Singh KA, Lele TP, Gaharwar AK Journal of biomedical materials research. Part A 37199446 J Biomed Mater Res A 2023 Oct https://www.ncbi.nlm.nih.gov/pubmed/37199446
Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips. Mathur T, Singh KA, R Pandian NK, Tsai SH, Hein TW, Gaharwar AK, Flanagan JM, Jain A Lab on a chip 31246211 Lab Chip 2019 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/31246211
Animal models of postpartum hemorrhage. Hargett SE, Leslie EF, Chapa HO, Gaharwar AK Lab animal 38528231 Lab Anim (NY) 2024 Apr https://www.ncbi.nlm.nih.gov/pubmed/38528231
Intra-Articular Injectable Biomaterials for Cartilage Repair and Regeneration. Kalairaj MS, Pradhan R, Saleem W, Smith MM, Gaharwar AK Advanced healthcare materials 38324655 Adv Healthc Mater 2024 Jul https://www.ncbi.nlm.nih.gov/pubmed/38324655
Nanoengineered Shape-Memory Hemostat. Hargett SE, Lokhande GK, Duran J, Hirani Z, Jang LK, Foster S, Deo KA, George S, Javed M, Ware TH, Maitland DJ, Gaharwar AK Small science 40213067 Small Sci 2025 Feb https://www.ncbi.nlm.nih.gov/pubmed/40213067

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