Molecular Libraries and Imaging
Molecular Libraries and Imaging
Publications Search by Program
Search Results
The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.
| Title | Authors | Journal | PubMedID | Publication Date |
|---|---|---|---|---|
| A Novel Inhibitor of Alpha- Galactosidase Identified from a Compound Library Screen | Motabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng W | Current Chemical Genomics | 999999929 | 2010 |
| Fluorescence polarization assays in small molecule screening | Lea, W. L., and Simeonov, A. | Expert Op Drug Disc | 999999928 | 2011 |
| The Ups and Downs of Structure-Activity Landscapes | Guha R. | Methods Mol Biol. | 999999927 | 2011 |
| The Ups and Downs of Structure-Activity Landscapes | Guha R. | Cheminformatics and Computational Chemical Biology | 999999926 | 2011 |
| Understanding Enzymes as Reporters or Targets in Assays Using Quantitative High-Throughput Screening (qHTS) | Auld DS, Thorne N, Boxer MB, Southall N, Shen M, Thomas CJ, Inglese J | 4th International ESCEC Symposium on Experimental Standard Conditions of Enzyme Characterizations | 999999925 | 2010 |
| Identification and validation of clinically utilized drugs for the treatment of adrenocortical cancer | Nilubol N, Zhang L, Shen M, Zhang Y-Q, He M, Kebebew E | Endocrine-Related Cancer | 999999924 | 2012 |
| Interplay between Tdp1, CtIP and PARP for the Repair of Topoisomerase I and II-induced DNA Damage in Vertebrate Cells | Murai J, Huang S-Y N, Das BB, Dexheimer TS, Takeda S, Pommier Y | PloS Genetics | 999999923 | 2012 |
| A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase | Morgan HP, Walsh M, Boxer M, Shen M, Blackburn EA, Wear MA, McNae IW, Nowicki MW, Michels P A-M, Auld DS, Fothergill-Gilmore LA & Walkinshaw MD | J. Biological Chemistry | 999999922 | 2012 |
| NRG1-ErbB4-p110δ signaling in schizophrenia. Reversal of amphetamine-induced behaviors by selective p110δ inhibition | Law AJ, Wang Y, Sei Y, Papaleo F, Huang W, Thomas CJ, Austin CP, Harrison PJ, Lipska BK, Hyde TM, Kleinman JE, Weinberger DR | Proc Natl Acad Sci USA | 999999921 | 2012 |
| Physiopathological role of the Neuropeptide S system in cocaine relapse: A mechanism mediated by the hypothalamic hypocretin system | Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R | Proc Natl Acad Sci USA | 999999920 | 2010 |
| Computational approaches in cheminformatics and bioinformatics | Guha R, Bender A. | 1st ed Hoboken | 999999919 | 2012 |
| Exploring Structure-activity-relationships to design novel drugs | Guha, R. | Silico Models for Drug Discovery | 999999918 | 2012 |
| Selecting, acquiring and using small molecule libraries for high-throughput screening | Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ | Curr. Prot. Chem. Biol. | 999999917 | 2012 |
| A High Affinity αIIbβ3 Antagonist Displays a Novel Mechanism of Inhibiting Ligand Binding, Competing with Mg2+ for Interacting with the MIDAS Glu220 | Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Zhu J, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS | Nat. Struct. Mol. Biol. | 999999916 | 2011 |
| Molecular Sensors for Transcriptional and Post-Transcriptional Assays | Auld DS & Thorne N | Chemical Genomics | 999999915 | 2011 |
| Urotensin-II Receptor Antagonists: From Peptides to Small-Molecules. Assessment of Potency, Selectivity, and In Vitro ADME Properties | Luci D, Maloney D | Diane Luci: ACS | 999999914 | 2011 |
| Chapter 16. Tyrosyl DNA-phosphodiesterase | Dexheimer TS, Huang S-YN, Das BB, Pommier Y | DNA Topoisomerases and Cancer. Cancer Drug Discovery and Development | 999999913 | 2012 |
| Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New Bioactive Compounds | Benson SC, Lee L, Wei W, Ni F, Olmos JDJ, Strom KR, Beeler AB, Cheng KC-C, Inglese J, Kota S, Takahashi V, Strosberg AD, Connor JH, Bushkin GG, Snyder JK | Heterocycles | 999999912 | 2011 |
| On Exploring Structure Activity Relationships | Guha R | Silico Models for Drug Discovery | 999999911 | 2013 |
| Decreased Subcutaneous Bioavailability of an Oxyntomodulin Analog in a Controlled Release Formulation could be Caused by Skin Metabolism in Rats | Wang M, Defranco D, Wright K, Quazi S, Chen J, Spencer-Pierce J, Zaghloul I, Pak R, Darvari R, Krishnan A, Perreault M, Sun L, Ozer J, O’Hara D, Rup B, and Xu X | J Bioequiv Availab | 999999910 | 2012 |
| Perspectives and Challenges in Epigenetic Therapy: DNA Methylation in Cancer Stem Cells. Book Chapter in: DNA Methylation: Principles, Mechanisms and Challenges | Sun L, Yang A, Cabarcas SM, Mathews LA, Farrar W | Nova Science Publisher | 999999909 | 2013 |
| Pharmaceutical Profiling Case Study in Disruption | Kerns, EH. | ACS Med Chem Lett | 999999908 | 2013 |
| CD28-ITK signals regulate autoreactive T cell trafficking into tissues | Jain M, Jiang J-k, Greiner D, Thomas CJ, Berg LJ, Kang J | The Journal of Immunology | 999999907 | 2012 |
| Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors | Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP Johnson RL, Huang W Littman DR | ACS Med Chem Lett. | 999999906 | 2012 |
| Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources | Guha R, Nguyen D-T, Southall N, Jadhav A | Current Protocols in Chemical Biology | 999999905 | 2012 |
| Exploring Structure-Activity Data Using the Landscape Paradigm | Guha | WIREs Comput Mol Sci, 2 | 999999904 | 2012 |
| Reply to Kojo: Mechanisms of antioxidant-induced DNA damage | Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K | Proc Natl Acad Sci USA | 999999903 | 2012 |
| Selecting, acquiring and using small molecule libraries for high-throughput screening | Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ | Current Protocols in Chemical Biology | 999999902 | 2012 |
| Toxicity testing with Heparg spheroids | Auld DS, Lea W, Davis MI, Simeonov A | ASSAY and Drug Development Technologies | 999999901 | 2012 |
| A proteomics landscape of circadian clock in mouse liver. | Wang, Yunzhi; Song, Lei; Liu, Mingwei; Ge, Rui; Zhou, Quan; Liu, Wanlin; Li, Ruiyang; Qie, Jingbo; Zhen, Bei; Wang, Yi; He, Fuchu; Qin, Jun; Ding, Chen | Nature communications. | 29674717 | 2018 Apr 19; |
| Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition. | Koplev, Simon; Lin, Katie; Dohlman, Anders B; Ma'ayan, Avi | PLoS computational biology. | 29293502 | 2018 01; |
| D4dopamine receptor high-resolution structures enable the discovery of selective agonists. | Wang, Sheng; Wacker, Daniel; Levit, Anat; Che, Tao; Betz, Robin M; McCorvy, John D; Venkatakrishnan, A J; Huang, Xi-Ping; Dror, Ron O; Shoichet, Brian K; Roth, Bryan L | Science (New York, N.Y.). | 29051383 | 2017 10 20; |
| Systems Medicine Approaches to Improving Understanding, Treatment, and Clinical Management of Neuroendocrine Prostate Cancer. | Yadav, Kamlesh K; Shameer, Khader; Readhead, Ben; Yadav, Shalini S; Li, Li; Kasarskis, Andrew; Tewari, Ashutosh K; Dudley, Joel T | Current pharmaceutical design. | 27174811 | 2016; |
| Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. | Vardy, Eyal; Sassano, Maria F; Rennekamp, Andrew J; Kroeze, Wesley K; Mosier, Philip D; Westkaemper, Richard B; Stevens, Craig W; Katritch, Vsevolod; Stevens, Raymond C; Peterson, Randall T; Roth, Bryan L | Chemistry & biology. | 26091169 | 2015 Jun 18; |
| Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors. | Tsai, Yihsuan S; Dominguez, Daniel; Gomez, Shawn M; Wang, Zefeng | Oncotarget. | 25749525 | 2015 Mar 30; |
| Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. | Duarte, Luis F; Young, Andrew R J; Wang, Zichen; Wu, Hsan-Au; Panda, Taniya; Kou, Yan; Kapoor, Avnish; Hasson, Dan; Mills, Nicholas R; Ma'ayan, Avi; Narita, Masashi; Bernstein, Emily | Nature communications. | 25394905 | 2014; |
| A blueprint of cell identity. | Ma'ayan, Avi; Duan, Qiaonan | Nature biotechnology. | 25299921 | 2014 Oct; |
| Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment. | Petrukhin, Konstantin | Drug discovery today. Therapeutic strategies | 25152755 | 2013 |
| Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification. | Sahn, James J; Granger, Brett A; Martin, Stephen F | Organic & biomolecular chemistry | 25135846 | 2014 Aug 19 |
| Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes. | Yu, Yi-Yun; Georg, Gunda I | Advanced synthesis & catalysis | 25071423 | 2014 Apr 14 |
| A high throughput flow cytometric assay platform targeting transporter inhibition. | Tegos, George P; Evangelisti, Annette M; Strouse, J Jacob; Ursu, Oleg; Bologa, Cristian; Sklar, Larry A | Drug discovery today. Technologies | 25027381 | 2014 Jun |
| Synthesis of the rosette-inducing factor RIF-1 and analogs. | Beemelmanns, Christine; Woznica, Arielle; Alegado, Rosanna A; Cantley, Alexandra M; King, Nicole; Clardy, Jon | Journal of the American Chemical Society | 24983513 | 2014 Jul 23 |
| Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis. | Goller, Carlos C; Arshad, Mehreen; Noah, James W; Ananthan, Subramaniam; Evans, Carrie W; Nebane, N Miranda; Rasmussen, Lynn; Sosa, Melinda; Tower, Nichole A; White, E Lucile; Neuenswander, Benjamin; Porubsky, Patrick; Maki, Brooks E; Rogers, Steven A; Sc | PloS one | 24983234 | 2014 |
| Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons. | Parks, Gregory S; Wang, Lien; Wang, Zhiwei; Civelli, Olivier | The Journal of comparative neurology | 24978951 | 2014 Jun 30 |
| Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process. | Medda, Federico; Hulme, Christopher | Tetrahedron letters | 24954960 | 2014 May 1 |
| Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. | Sully, Erin K; Malachowa, Natalia; Elmore, Bradley O; Alexander, Susan M; Femling, Jon K; Gray, Brian M; DeLeo, Frank R; Otto, Michael; Cheung, Ambrose L; Edwards, Bruce S; Sklar, Larry A; Horswill, Alexander R; Hall, Pamela R; Gresham, Hattie D | PLoS pathogens | 24945495 | 2014 Jun |
| Novel succinct routes to Quinoxalines and 2-Benzimidazolylquinoxalines via the Ugi reaction. | Ayaz, Muhammad; Xu, Zhigang; Hulme, Christopher | Tetrahedron letters | 24932052 | 2014 Jun 4 |
| Enzyme inhibitor discovery by activity-based protein profiling. | Niphakis, Micah J; Cravatt, Benjamin F | Annual review of biochemistry | 24905785 | 2014 |
| Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. | Du, Lin; Robles, Andrew J; King, Jarrod B; Mooberry, Susan L; Cichewicz, Robert H | Journal of natural products | 24893224 | 2014 Jun 27 |
| Thielavialides A-E, nor-spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, an endophytic fungus isolated from aeroponically grown Physalis alkekengi. | Wijeratne, E M Kithsiri; Espinosa-Artiles, Patricia; Gruener, Raphael; Gunatilaka, A A Leslie | Journal of natural products | 24882589 | 2014 Jun 27 |
| Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. | Chou, Tsui-Fen; Bulfer, Stacie L; Weihl, Conrad C; Li, Kelin; Lis, Lev G; Walters, Michael A; Schoenen, Frank J; Lin, Henry J; Deshaies, Raymond J; Arkin, Michelle R | Journal of molecular biology | 24878061 | 2014 Jul 29 |
| A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor. | Conn, P Michael; Smith, Emery; Spicer, Timothy; Chase, Peter; Scampavia, Louis; Janovick, Jo Ann | Assay and drug development technologies | 24831790 | 2014 May |
| Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. | Sun, Haiyan; Wei, Ying; Deng, Huayun; Xiong, Qiaojie; Li, Min; Lahiri, Joydeep; Fang, Ye | Scientific reports | 24816792 | 2014 |
| Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. | Low, Yen Sia; Sedykh, Alexander Yeugenyevich; Rusyn, Ivan; Tropsha, Alexander | Current topics in medicinal chemistry | 24805064 | 2014 |
| Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs. | Wenthur, Cody J; Morrison, Ryan D; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 24794112 | 2014 Jun 15 |
| Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella. | Kwan, Jason C; Tianero, Ma Diarey B; Donia, Mohamed S; Wyche, Thomas P; Bugni, Tim S; Schmidt, Eric W | PloS one | 24788869 | 2014 |
| Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions. | Martinez-Ariza, Guillermo; Ayaz, Muhammad; Medda, Federico; Hulme, Christopher | The Journal of organic chemistry | 24788091 | 2014 Jun 6 |
| Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2H)-ones and 2,3-dihydropyridin-4(1H)-ones from *-substituted *-hydroxyaminoaldehydes. | Ranade, Adwait R; Georg, Gunda I | The Journal of organic chemistry | 24785413 | 2014 Feb 7 |
| 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. | Abulwerdi, Fardokht A; Liao, Chenzhong; Mady, Ahmed S; Gavin, Jordan; Shen, Chenxi; Cierpicki, Tomasz; Stuckey, Jeanne A; Showalter, H D Hollis; Nikolovska-Coleska, Zaneta | Journal of medicinal chemistry | 24749893 | 2014 May 22 |
| Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. | Yan, Fei; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; O'Malley, Bert W; Lonard, David M | PloS one | 24743578 | 2014 |
| Protein chaperones: a composition of matter review (2008 - 2013). | Taldone, Tony; Patel, Hardik J; Bolaender, Alexander; Patel, Maulik R; Chiosis, Gabriela | Expert opinion on therapeutic patents | 24742089 | 2014 May |
| Solvent-dependent divergent functions of Sc(OTf)ýýý in stereoselective epoxide-opening spiroketalizations. | Sharma, Indrajeet; Wurst, Jacqueline M; Tan, Derek S | Organic letters | 24742081 | 2014 May 2 |
| Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth. | Sarkisyan, Gor; Gay, Laurie J; Nguyen, Nhan; Felding, Brunhilde H; Rosen, Hugh | American journal of physiology. Cell physiology | 24740542 | 2014 Jul 1 |
| Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | Oldstone, Michael B A; Rosen, Hugh | Current topics in microbiology and immunology | 24728596 | 2014 |
| Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics. | Swale, Daniel R; Kharade, Sujay V; Denton, Jerod S | Current opinion in pharmacology | 24721648 | 2014 Apr |
| Evaluation of prostate-specific membrane antigen as an imaging reporter. | Castanares, Mark A; Mukherjee, Amarnath; Chowdhury, Wasim H; Liu, Minzhi; Chen, Ying; Mease, Ronnie C; Wang, Yuchuan; Rodriguez, Ronald; Lupold, Shawn E; Pomper, Martin G | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 24700883 | 2014 May |
| Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5 -Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe. | Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P Jef | ChemMedChem | 24692176 | 2014 Apr 1 |
| Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. | Gavrish, Ekaterina; Sit, Clarissa S; Cao, Shugeng; Kandror, Olga; Spoering, Amy; Peoples, Aaron; Ling, Losee; Fetterman, Ashley; Hughes, Dallas; Bissell, Anthony; Torrey, Heather; Akopian, Tatos; Mueller, Andreas; Epstein, Slava; Goldberg, Alfred; Clardy, | Chemistry & biology | 24684906 | 2014 Apr 24 |
| Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. | Rai, Ganesha; Joshi, Netra; Jung, Joo Eun; Liu, Yu; Schultz, Lena; Yasgar, Adam; Perry, Steve; Diaz, Giovanni; Zhang, Qiangli; Kenyon, Victor; Jadhav, Ajit; Simeonov, Anton; Lo, Eng H; van Leyen, Klaus; Maloney, David J; Holman, Theodore R | Journal of medicinal chemistry | 24684213 | 2014 May 22 |
| Protein phosphatases in pancreatic islets. | Ortsater, Henrik; Grankvist, Nina; Honkanen, Richard E; Sjoholm, Ake | The Journal of endocrinology | 24681827 | 2014 Jun |
| Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. | Walsh, Kevin B; Teijaro, John R; Brock, Linda G; Fremgen, Daniel M; Collins, Peter L; Rosen, Hugh; Oldstone, Michael B A | Journal of virology | 24672024 | 2014 Jun |
| The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions. | Prohaska, Kimberly M; Bennett, Ryan P; Salter, Jason D; Smith, Harold C | Wiley interdisciplinary reviews. RNA | 24664896 | 2014 Mar 24 |
| Synthesis of novel peptidyl adenosine antibiotic analogs. | Moukha-Chafiq, Omar; Reynolds, Robert C | Nucleosides, nucleotides & nucleic acids | 24660880 | 2014 |
| Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis. | Kim, Yong Wook; Georg, Gunda I | Organic letters | 24650204 | 2014 Mar 21 |
| In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4. | Mandal, Nawajes A; Tran, Julie-Thu A; Zheng, Lixin; Wilkerson, Joseph L; Brush, Richard S; McRae, Joel; Agbaga, Martin-Paul; Zhang, Kang; Petrukhin, Konstantin; Ayyagari, Radha; Anderson, Robert E | Investigative ophthalmology & visual science | 24644051 | 2014 Apr |
| A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence. | Vekariya, Rakesh H; Liu, Ruzhang; Aube, Jeffrey | Organic letters | 24635056 | 2014 Apr 4 |
| Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives. | Pagano, Nicholas; Heil, Marintha L; Cosford, Nicholas D P | Synthesis | 24634547 | 2012 |
| Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. | Yuan, Hsiangkuo; Wilson, Christy M; Xia, Jun; Doyle, Sarah L; Li, Shuqin; Fales, Andrew M; Liu, Yang; Ozaki, Ema; Mulfaul, Kelly; Hanna, Gabi; Palmer, Gregory M; Wang, Lihong V; Grant, Gerald A; Vo-Dinh, Tuan | Nanoscale | 24619405 | 2014 Apr 21 |
| Equilibrium and kinetics of Sin Nombre hantavirus binding at DAF/CD55 functionalized bead surfaces. | Buranda, Tione; Swanson, Scarlett; Bondu, Virginie; Schaefer, Leah; Maclean, James; Mo, Zhenzhen; Wycoff, Keith; Belle, Archana; Hjelle, Brian | Viruses | 24618810 | 2014 |
| Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. | Ziemert, Nadine; Lechner, Anna; Wietz, Matthias; Millan-Aguinaga, Natalie; Chavarria, Krystle L; Jensen, Paul Robert | Proceedings of the National Academy of Sciences of the United States of America | 24616526 | 2014 Mar 25 |
| A chimeric siderophore halts swarming Vibrio. | Bottcher, Thomas; Clardy, Jon | Angewandte Chemie (International ed. in English) | 24615751 | 2014 Mar 24 |
| Discovery of ML314, a Brain Penetrant Non-Peptidic *-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. | Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Maloney, Patrick R; Li, Yujie; Milewski, Monika; Gosalia, Palak; Gray, Wilson; Mehta, Alka; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Heynen-Genel, Susanne; Vasile, Stefa | ACS medicinal chemistry letters | 24611085 | 2013 Jul 20 |
| Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy. | Teijaro, John R; Walsh, Kevin B; Long, James P; Tordoff, Kevin P; Stark, Gregory V; Eisfeld, Amie J; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B A | Virology | 24606692 | 2014 Mar |
| Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors. | Brahimi, Fouad; Ko, Eunhwa; Malakhov, Andrey; Burgess, Kevin; Saragovi, H Uri | PloS one | 24603864 | 2014 |
| Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. | Kwan, Jason C; Liu, Yanxia; Ratnayake, Ranjala; Hatano, Ryo; Kuribara, Akiko; Morimoto, Chiko; Ohnuma, Kei; Paul, Valerie J; Ye, Tao; Luesch, Hendrik | Chembiochem : a European journal of chemical biology | 24591193 | 2014 Apr 14 |
| Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor ýý is therapeutic in the collagen-induced arthritis experimental model. | Chang, Mi Ra; Lyda, Brent; Kamenecka, Theodore M; Griffin, Patrick R | Arthritis & rheumatology (Hoboken, N.J.) | 24574218 | 2014 Mar |
| Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. | Gonzalez, David J; Vuong, Lisa; Gonzalez, Isaiah S; Keller, Nadia; McGrosso, Dominic; Hwang, John H; Hung, Jun; Zinkernagel, Annelies; Dixon, Jack E; Dorrestein, Pieter C; Nizet, Victor | Molecular & cellular proteomics : MCP | 24567418 | 2014 May |
| Diastereoselective synthesis of ýý- and ýý-lactams from imines and sulfone-substituted anhydrides. | Sorto, Nohemy A; Di Maso, Michael J; Munoz, Manuel A; Dougherty, Ryan J; Fettinger, James C; Shaw, Jared T | The Journal of organic chemistry | 24552208 | 2014 Mar 21 |
| MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines. | Bell, Christan E; Shaw, Arthur Y; De Moliner, Fabio; Hulme, Christopher | Tetrahedron | 24535889 | 2014 Jan 7 |
| Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp. | Ellis, Gregory A; Wyche, Thomas P; Fry, Charles G; Braun, Doug R; Bugni, Tim S | Marine drugs | 24534844 | 2014 Feb |
| Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site. | Gregory, Karen J; Nguyen, Elizabeth D; Malosh, Chrysa; Mendenhall, Jeffrey L; Zic, Jessica Z; Bates, Brittney S; Noetzel, Meredith J; Squire, Emma F; Turner, Eric M; Rook, Jerri M; Emmitte, Kyle A; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn, | ACS chemical neuroscience | 24528109 | 2014 Apr 16 |
| M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses. | Pancani, Tristano; Bolarinwa, Caroline; Smith, Yoland; Lindsley, Craig W; Conn, P Jeffrey; Xiang, Zixiu | ACS chemical neuroscience | 24528004 | 2014 Apr 16 |
| Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. | Bandyopadhyay, Sanghamitra; Rogers, Jack T | Biochemical pharmacology | 24513321 | 2014 Apr 15 |
| Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor. | Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry A | Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] | 24510772 | 2014 |
| Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor. | Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry A | Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] | 24510772 | 2014 |
| Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. | Xie, Pengfei; Ma, Ming; Rateb, Mostafa E; Shaaban, Khaled A; Yu, Zhiguo; Huang, Sheng-Xiong; Zhao, Li-Xing; Zhu, Xiangcheng; Yan, Yijun; Peterson, Ryan M; Lohman, Jeremy R; Yang, Dong; Yin, Min; Rudolf, Jeffrey D; Jiang, Yi; Duan, Yanwen; Shen, Ben | Journal of natural products | 24484381 | 2014 Feb 28 |
| Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. | Neochoritis, Constantinos G; Domling, Alexander | Organic & biomolecular chemistry | 24477767 | 2014 Mar 14 |
| Programmed death-1: therapeutic success after more than 100ýýýyears of cancer immunotherapy. | Domling, Alexander; Holak, Tad A | Angewandte Chemie (International ed. in English) | 24474145 | 2014 Feb 24 |
| Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. | Fan, Longchang; Guan, Xiaowei; Wang, Wei; Zhao, Jian-Yuan; Zhang, Hongkang; Tiwari, Vinod; Hoffman, Paul N; Li, Min; Tao, Yuan-Xiang | Molecular pain | 24472174 | 2014 |
| High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. | He, Shihan; Senter, Timothy J; Pollock, Jonathan; Han, Changho; Upadhyay, Sunil Kumar; Purohit, Trupta; Gogliotti, Rocco D; Lindsley, Craig W; Cierpicki, Tomasz; Stauffer, Shaun R; Grembecka, Jolanta | Journal of medicinal chemistry | 24472025 | 2014 Feb 27 |
| Chemo- and site-selective derivatizations of natural products enabling biological studies. | Robles, Omar; Romo, Daniel | Natural product reports | 24468713 | 2014 Mar |
| Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. | Gao, Wei; Sun, Hai-Xi; Xiao, Hongbin; Cui, Guanghong; Hillwig, Matthew L; Jackson, Alana; Wang, Xiao; Shen, Ye; Zhao, Nan; Zhang, Liangxiao; Wang, Xiu-Jie; Peters, Reuben J; Huang, Luqi | BMC genomics | 24467826 | 2014 |
| A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. | Lewallen, Daniel M; Bicker, Kevin L; Madoux, Franck; Chase, Peter; Anguish, Lynne; Coonrod, Scott; Hodder, Peter; Thompson, Paul R | ACS chemical biology | 24467619 | 2014 Apr 18 |
| Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. | Sheffler, Douglas J; Nedelovych, Michael T; Williams, Richard; Turner, Stephen C; Duerk, Brittany B; Robbins, Megan R; Jadhav, Sataya B; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Daniels, R Nathan; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 24462664 | 2014 Feb 15 |
| Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. | Jones, Carrie K; Sheffler, Douglas J; Williams, Richard; Jadhav, Sataya B; Felts, Andrew S; Morrison, Ryan D; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 24461352 | 2014 Feb 15 |
| A novel class of ion displacement ligands as antagonists of the *IIb*3 receptor that limit conformational reorganization of the receptor. | Jiang, Jian-kang; McCoy, Joshua G; Shen, Min; LeClair, Christopher A; Huang, Wenwei; Negri, Ana; Li, Jihong; Blue, Robert; Harrington, Amanda Weil; Naini, Sarasija; David 3rd, George; Choi, Won-Seok; Volpi, Elisabetta; Fernandez, Joseph; Babayeva, Mariana | Bioorganic & medicinal chemistry letters | 24461295 | 2014 Feb 15 |
| Probing chemical space with alkaloid-inspired libraries. | McLeod, Michael C; Singh, Gurpreet; Plampin 3rd, James N; Rane, Digamber; Wang, Jenna L; Day, Victor W; Aube, Jeffrey | Nature chemistry | 24451589 | 2014 Feb |
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| Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. | Dreyton, Christina J; Anderson, Erin D; Subramanian, Venkataraman; Boger, Dale L; Thompson, Paul R | Bioorganic & medicinal chemistry | 24440480 | 2014 Feb 15 |
| Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model. | Aldrich, Leslie N; Berry, Cynthia B; Bates, Brittney S; Konkol, Leah C; So, Miranda; Lindsley, Craig W | European journal of organic chemistry | 24415906 | 2013 Jul 1 |
| Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. | Ardecky, Robert J; Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Brown, Brock; Ganji, Santhi; Zou, Jiwen; Pass, Ian; Narisawa, Sonoko; Iano, Flavia Godoy; Rosenstein, Craig; Cheltsov, Anton; Rascon, Justin; Hedrick, Michael; Gasior, Carlton; Forster, Anita; | Bioorganic & medicinal chemistry letters | 24412070 | 2014 Feb 1 |
| The University of New Mexico Center for Molecular Discovery. | Edwards, Bruce S; Gouveia, Kristine; Oprea, Tudor I; Sklar, Larry A | Combinatorial chemistry & high throughput screening | 24409953 | 2014 Mar |
| Collaborative pre-competitive preclinical drug discovery with academics and pharma/biotech partners at Sanford|Burnham: infrastructure, capabilities & operational models. | Chung, Thomas D Y | Combinatorial chemistry & high throughput screening | 24409951 | 2014 Mar |
| Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. | Huang, Yijun; Wolf, Siglinde; Beck, Barbara; Kohler, Lisa-Maria; Khoury, Kareem; Popowicz, Grzegorz M; Goda, Sayed K; Subklewe, Marion; Twarda, Aleksandra; Holak, Tad A; Domling, Alexander | ACS chemical biology | 24405416 | 2014 Mar 21 |
| Covalent inhibition of the lymphoid tyrosine phosphatase. | Ahmed, Vanessa F; Bottini, Nunzio; Barrios, Amy M | ChemMedChem | 24403103 | 2014 Feb |
| Grubbs cross-metathesis pathway for a scalable synthesis of ýý-keto-*,*-unsaturated esters. | Nair, Reji N; Bannister, Thomas D | The Journal of organic chemistry | 24393145 | 2014 Feb 7 |
| Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. | Luci, Diane K; Jameson 2nd, J Brian; Yasgar, Adam; Diaz, Giovanni; Joshi, Netra; Kantz, Auric; Markham, Kate; Perry, Steve; Kuhn, Norine; Yeung, Jennifer; Kerns, Edward H; Schultz, Lena; Holinstat, Michael; Nadler, Jerry L; Taylor-Fishwick, David A; Jadha | Journal of medicinal chemistry | 24393039 | 2014 Jan 23 |
| Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. | Wang, Ying; Lonard, David M; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy G; Wang, Jin; Qi, Ruogu; Matzuk, Alexander J; Song, Xianzhou; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; Zhou, Suoling; Liao, Lan; Xu, Jianming; O'Malley, Bert | Cancer research | 24390736 | 2014 Mar 1 |
| A novel analgesic isolated from a traditional chinese medicine. | Zhang, Yan; Wang, Chaoran; Wang, Lien; Parks, Gregory Scott; Zhang, Xiuli; Guo, Zhimou; Ke, Yanxiong; Li, Kang-Wu; Kim, Mi Kyeong; Vo, Benjamin; Borrelli, Emiliana; Ge, Guangbo; Yang, Ling; Wang, Zhiwei; Garcia-Fuster, M Julia; Luo, Z David; Liang, Xinmia | Current biology : CB | 24388848 | 2014 Jan 20 |
| High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity. | Ofori, Leslie O; Hilimire, Thomas A; Bennett, Ryan P; Brown Jr, Nathaniel W; Smith, Harold C; Miller, Benjamin L | Journal of medicinal chemistry | 24387306 | 2014 Feb 13 |
| Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. | Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Chris A; Bi, Danse; Basha, Fatima Z; Hanson, Paul R | Heterocycles | 24385680 | 2012 Dec 31 |
| Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol. | Zang, Qin; Zhou, Aihua; Javed, Salim; Maity, Pradip K; Knudtson, Chris A; Bi, Danse; Hastings, Jared J; Basha, Fatima Z; Hanson, Paul R | Heterocycles | 24385679 | 2012 Dec 31 |
| Activation of the nuclear factor e2-related factor 2 pathway by novel natural products halomadurones a-d and a synthetic analogue. | Wyche, Thomas P; Standiford, Miranda; Hou, Yanpeng; Braun, Doug; Johnson, Delinda A; Johnson, Jeffrey A; Bugni, Tim S | Marine drugs | 24351907 | 2013 |
| Counterion effects in the catalytic stereoselective synthesis of 2,3'-pyrrolidinyl spirooxindoles. | MacDonald, Jacob P; Shupe, Benjamin H; Schreiber, John D; Franz, Annaliese K | Chemical communications (Cambridge, England) | 24336395 | 2014 May 25 |
| Imidazole-derived agonists for the neurotensin 1 receptor. | Hershberger, Paul M; Hedrick, Michael P; Peddibhotla, Satyamaheshwar; Mangravita-Novo, Arianna; Gosalia, Palak; Li, Yujie; Gray, Wilson; Vicchiarelli, Michael; Smith, Layton H; Chung, Thomas D Y; Thomas, James B; Caron, Marc G; Pinkerton, Anthony B; Barak | Bioorganic & medicinal chemistry letters | 24332089 | 2014 Jan 1 |
| A simple one-pot 2-step N-1-alkylation of indoles with *-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles. | Martinez-Ariza, Guillermo; Ayaz, Muhammad; Hulme, Christopher | Tetrahedron letters | 24327792 | 2013 Dec 4 |
| Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones. | Singh, Gurpreet; Meyer, Angelica; Aube, Jeffrey | The Journal of organic chemistry | 24325280 | 2014 Jan 3 |
| Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism. | Kwan, Jason C; Schmidt, Eric W | PloS one | 24324632 | 2013 |
| Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. | Zaytseva, Natalya; Lynn, Jeffery G; Wu, Qi; Mudaliar, Deepti J; Sun, Haiyan; Kuang, Patty Q; Fang, Ye | Sensors and actuators. B, Chemical | 24319319 | 2013 Nov |
| High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. | Sharma, Kamal; Choi, Se-Young; Zhang, Yong; Nieland, Thomas J F; Long, Shunyou; Li, Min; Huganir, Richard L | Cell reports | 24316074 | 2013 Dec 12 |
| Application of ion-sensitive field effect transistors for ion channel screening. | Walsh, Kenneth B; DeRoller, Nicholas; Zhu, Yihao; Koley, Goutam | Biosensors & bioelectronics | 24315877 | 2014 Apr 15 |
| Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams. | Asad, Naeem; Samarakoon, Thiwanka B; Zang, Qin; Loh, Joanna K; Javed, Salim; Hanson, Paul R | Organic letters | 24313225 | 2014 Jan 3 |
| Multiplex cytological profiling assay to measure diverse cellular states. | Gustafsdottir, Sigrun M; Ljosa, Vebjorn; Sokolnicki, Katherine L; Anthony Wilson, J; Walpita, Deepika; Kemp, Melissa M; Petri Seiler, Kathleen; Carrel, Hyman A; Golub, Todd R; Schreiber, Stuart L; Clemons, Paul A; Carpenter, Anne E; Shamji, Alykhan F | PloS one | 24312513 | 2013 |
| Multiplex cytological profiling assay to measure diverse cellular states. | Gustafsdottir, Sigrun M; Ljosa, Vebjorn; Sokolnicki, Katherine L; Anthony Wilson, J; Walpita, Deepika; Kemp, Melissa M; Petri Seiler, Kathleen; Carrel, Hyman A; Golub, Todd R; Schreiber, Stuart L; Clemons, Paul A; Carpenter, Anne E; Shamji, Alykhan F | PloS one | 24312513 | 2013 |
| Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. | Yun, Bogeon; Lee, HeeJung; Ghosh, Moumita; Cravatt, Benjamin F; Hsu, Ku-Lung; Bonventre, Joseph V; Ewing, Heather; Gelb, Michael H; Leslie, Christina C | The Journal of biological chemistry | 24297180 | 2014 Jan 17 |
| An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support. | Fei, Yiyan; Landry, James P; Li, Yanhong; Yu, Hai; Lau, Kam; Huang, Shengshu; Chokhawala, Harshal A; Chen, Xi; Zhu, X D | The Review of scientific instruments | 24289409 | 2013 Nov |
| Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. | Doherty, Joanne R; Yang, Chunying; Scott, Kristen E N; Cameron, Michael D; Fallahi, Mohammad; Li, Weimin; Hall, Mark A; Amelio, Antonio L; Mishra, Jitendra K; Li, Fangzheng; Tortosa, Mariola; Genau, Heide Marika; Rounbehler, Robert J; Lu, Yunqi; Dang, Chi | Cancer research | 24285728 | 2014 Feb 1 |
| Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. | Du, Lin; Robles, Andrew J; King, Jarrod B; Powell, Douglas R; Miller, Andrew N; Mooberry, Susan L; Cichewicz, Robert H | Angewandte Chemie (International ed. in English) | 24285637 | 2014 Jan 13 |
| Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating. | Zhang, Qiansen; Zhou, Pingzheng; Chen, Zhuxi; Li, Min; Jiang, Hualiang; Gao, Zhaobing; Yang, Huaiyu | Proceedings of the National Academy of Sciences of the United States of America | 24277843 | 2013 Dec 10 |
| Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. | Kotsikorou, Evangelia; Sharir, Haleli; Shore, Derek M; Hurst, Dow P; Lynch, Diane L; Madrigal, Karla E; Heynen-Genel, Susanne; Milan, Loribelle B; Chung, Thomas D Y; Seltzman, Herbert H; Bai, Yushi; Caron, Marc G; Barak, Larry S; Croatt, Mitchell P; Abood | Biochemistry | 24274581 | 2013 Dec 31 |
| Inhibiting AMPylation: A Novel Screen To Identify the First Small Molecule Inhibitors of Protein AMPylation. | Lewallen, Daniel M; Sreelatha, Anju; Dharmarajan, Venkatasubramanian; Madoux, Franck; Chase, Peter; Griffin, Patrick R; Orth, Kim; Hodder, Peter; Thompson, Paul R | ACS chemical biology | 24274060 | 2013 Nov 25 |
| Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. | Raphemot, Rene; Kadakia, Rishin J; Olsen, Michelle L; Banerjee, Sreedatta; Days, Emily; Smith, Stephen S; Weaver, C David; Denton, Jerod S | Assay and drug development technologies | 24266659 | 2013 Nov-Dec |
| Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells. | Bruntz, Ronald C; Taylor, Harry E; Lindsley, Craig W; Brown, H Alex | The Journal of biological chemistry | 24257753 | 2014 Jan 10 |
| Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC). | Chen, Haijun; Wild, Christopher; Zhou, Xiaobin; Ye, Na; Cheng, Xiaodong; Zhou, Jia | Journal of medicinal chemistry | 24256330 | 2013 Nov 27 |
| Secoemestrin D, a Cytotoxic Epitetrathiodioxopiperizine, and Emericellenes A-E, Five Sesterterpenoids from Emericella sp. AST0036, a Fungal Endophyte of Astragalus lentiginosus1. | Xu, Ya-Ming; Espinosa-Artiles, Patricia; Liu, Mangping X; Arnold, A Elizabeth; Gunatilaka, A A Leslie | Journal of natural products | 24251417 | 2013 Nov 19 |
| Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). | Ullah, Farman; Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Christopher A; Bi, Danse; Hanson, Paul R; Organ, Michael G | Journal of flow chemistry | 24244871 | 2012 Dec |
| Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). | Ullah, Farman; Zang, Qin; Javed, Salim; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul R; Organ, Michael G | Synthesis | 24244052 | 2012 |
| Deorphanizing the human transmembrane genome: A landscape of uncharacterized membrane proteins. | Babcock, Joseph J; Li, Min | Acta pharmacologica Sinica | 24241348 | 2014 Jan |
| Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. | Deng, Xianming; Elkins, Jonathan M; Zhang, Jinwei; Yang, Qingkai; Erazo, Tatiana; Gomez, Nestor; Choi, Hwan Geun; Wang, Jinhua; Dzamko, Nicolas; Lee, Jiing-Dwan; Sim, Taebo; Kim, NamDoo; Alessi, Dario R; Lizcano, Jose M; Knapp, Stefan; Gray, Nathanael S | European journal of medicinal chemistry | 24239623 | 2013 Dec |
| Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. | Deng, Xianming; Elkins, Jonathan M; Zhang, Jinwei; Yang, Qingkai; Erazo, Tatiana; Gomez, Nestor; Choi, Hwan Geun; Wang, Jinhua; Dzamko, Nicolas; Lee, Jiing-Dwan; Sim, Taebo; Kim, Namdoo; Alessi, Dario R; Lizcano, Jose M; Knapp, Stefan; Gray, Nathanael S | European journal of medicinal chemistry | 24239623 | 2013 Dec |
| Inhibition of the TRPC5 ion channel protects the kidney filter. | Schaldecker, Thomas; Kim, Sookyung; Tarabanis, Constantine; Tian, Dequan; Hakroush, Samy; Castonguay, Philip; Ahn, Wooin; Wallentin, Hanna; Heid, Hans; Hopkins, Corey R; Lindsley, Craig W; Riccio, Antonio; Buvall, Lisa; Weins, Astrid; Greka, Anna | The Journal of clinical investigation | 24231357 | 2013 Dec 2 |
| Transient protein states in designing inhibitors of the MDM2-p53 interaction. | Bista, Michal; Wolf, Siglinde; Khoury, Kareem; Kowalska, Kaja; Huang, Yijun; Wrona, Ewa; Arciniega, Marcelino; Popowicz, Grzegorz M; Holak, Tad A; Domling, Alexander | Structure (London, England : 1993) | 24207125 | 2013 Dec 3 |
| Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. | Li, Min; Khambu, Bilon; Zhang, Hao; Kang, Jeong-Han; Chen, Xiaoyun; Chen, Daohong; Vollmer, Laura; Liu, Pei-Qing; Vogt, Andreas; Yin, Xiao-Ming | The Journal of biological chemistry | 24174532 | 2013 Dec 13 |
| Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). | Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W | Journal of medicinal chemistry | 24164599 | 2013 Nov 27 |
| HIV-1 accessory proteins: VpR. | Zhao, Richard Y; Bukrinsky, Michael I | Methods in molecular biology (Clifton, N.J.) | 24158819 | 2014 |
| Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. | Hsu, Ku-Lung; Tsuboi, Katsunori; Whitby, Landon R; Speers, Anna E; Pugh, Holly; Inloes, Jordon; Cravatt, Benjamin F | Journal of medicinal chemistry | 24152245 | 2013 Nov 14 |
| MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. | Liu, Wei-Ting; Lamsa, Anne; Wong, Weng Ruh; Boudreau, Paul D; Kersten, Roland; Peng, Yao; Moree, Wilna J; Duggan, Brendan M; Moore, Bradley S; Gerwick, William H; Linington, Roger G; Pogliano, Kit; Dorrestein, Pieter C | The Journal of antibiotics | 24149839 | 2013 Oct 23 |
| Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans. | Stefan, Christopher P; Cunningham, Kyle W | The Journal of biological chemistry | 24142703 | 2013 Nov 29 |
| Human protamine-1 as an MRI reporter gene based on chemical exchange. | Bar-Shir, Amnon; Liu, Guanshu; Chan, Kannie W Y; Oskolkov, Nikita; Song, Xiaolei; Yadav, Nirbhay N; Walczak, Piotr; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf A | ACS chemical biology | 24138139 | 2014 Jan 17 |
| Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. | Guerrero, Miguel; Poddutoori, Ramulu; Urbano, Mariangela; Peng, Xuemei; Spicer, Timothy P; Chase, Peter S; Hodder, Peter S; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward | Bioorganic & medicinal chemistry letters | 24135724 | 2013 Dec 1 |
| Modulators of the Sphingosine 1-phosphate receptor 1. | Urbano, Mariangela; Guerrero, Miguel; Rosen, Hugh; Roberts, Edward | Bioorganic & medicinal chemistry letters | 24125884 | 2013 Dec 1 |
| Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI. | Liu, Guanshu; Bettegowda, Chetan; Qiao, Yuan; Staedtke, Verena; Chan, Kannie W Y; Bai, Renyuan; Li, Yuguo; Riggins, Gregory J; Kinzler, Kenneth W; Bulte, Jeff W M; McMahon, Michael T; Gilad, Assaf A; Vogelstein, Bert; Zhou, Shibin; van Zijl, Peter C M | Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 24123389 | 2013 Dec |
| A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth. | May, Elebeoba E; Leitao, Andrei; Tropsha, Alexander; Oprea, Tudor I | Computational biology and chemistry | 24121675 | 2013 Dec |
| Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3). | Robinson, James; Smith, Anthony; Sturchler, Emmanuel; Tabrizifard, Sahba; Kamenecka, Theodore; McDonald, Patricia | Assay and drug development technologies | 24116939 | 2013 Oct |
| A pilot biomedical engineering course in rapid prototyping for mobile health. | Stokes, Todd H; Venugopalan, Janani; Hubbard, Elena N; Wang, May D | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference | 24110238 | 2013 |
| Challenges and triumphs to genomics-based natural product discovery. | Jensen, Paul R; Chavarria, Krystle L; Fenical, William; Moore, Bradley S; Ziemert, Nadine | Journal of industrial microbiology & biotechnology | 24104399 | 2014 Feb |
| A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). | Shahinas, Dea; Folefoc, Asongna; Taldone, Tony; Chiosis, Gabriela; Crandall, Ian; Pillai, Dylan R | PloS one | 24098696 | 2013 |
| Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation. | Wan, Xia; Lu, Yungang; Chen, Xueqin; Xiong, Jian; Zhou, Yuanda; Li, Ping; Xia, Bingqing; Li, Min; Zhu, Michael X; Gao, Zhaobing | Pflugers Archiv : European journal of physiology | 24092046 | 2014 Jul |
| Selective photoinactivation of Candida albicans in the non-vertebrate host infection model Galleria mellonella. | Chibebe Junior, Jose; Sabino, Caetano P; Tan, Xiaojiang; Junqueira, Juliana C; Wang, Yan; Fuchs, Beth B; Jorge, Antonio O C; Tegos, George P; Hamblin, Michael R; Mylonakis, Eleftherios | BMC microbiology | 24083556 | 2013 |
| Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. | Turlington, Mark; Chun, Aspen; Tomar, Sakshi; Eggler, Aimee; Grum-Tokars, Valerie; Jacobs, Jon; Daniels, J Scott; Dawson, Eric; Saldanha, Adrian; Chase, Peter; Baez-Santos, Yahira M; Lindsley, Craig W; Hodder, Peter; Mesecar, Andrew D; Stauffer, Shaun R | Bioorganic & medicinal chemistry letters | 24080461 | 2013 Nov 15 |
| Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751. | Wijeratne, E M Kithsiri; He, Hongping; Franzblau, Scott G; Hoffman, Angela M; Gunatilaka, A A Leslie | Journal of natural products | 24079882 | 2013 Oct 25 |
| Stereocontrol in asymmetric ýý-lactam syntheses from imines and cyanosuccinic anhydrides. | Pattawong, Ommidala; Tan, Darlene Q; Fettinger, James C; Shaw, Jared T; Cheong, Paul Ha-Yeon | Organic letters | 24070216 | 2013 Oct 4 |
| Stereoselective synthesis of ýý-lactams from imines and cyanosuccinic anhydrides. | Tan, Darlene Q; Younai, Ashkaan; Pattawong, Ommidala; Fettinger, James C; Cheong, Paul Ha-Yeon; Shaw, Jared T | Organic letters | 24070117 | 2013 Oct 4 |
| Synthesis and Characterization of Thiolate-Oxo Ligated Zinc Alkyl Derivatives for Production of Zn-Based Nanoparticles. | Boyle, Timothy J; Pratt 3rd, Harry D; Alam, Todd M; Headley, Thomas; Rodriguez, Mark A | European journal of inorganic chemistry | 24068879 | 2009 Mar 1 |
| Indolo[3,2-a]carbazoles from a deep-water sponge of the genus Asteropus. | Russell, Floyd; Harmody, Dedra; McCarthy, Peter J; Pomponi, Shirley A; Wright, Amy E | Journal of natural products | 24063539 | 2013 Oct 25 |
| The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm. | Kapur, Sunil; Macrae, Calum A | Frontiers in physiology | 24062689 | 2013 |
| Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy. | Vo-Dinh, Tuan; Fales, Andrew M; Griffin, Guy D; Khoury, Christopher G; Liu, Yang; Ngo, Hoan; Norton, Stephen J; Register, Janna K; Wang, Hsin-Neng; Yuan, Hsiangkuo | Nanoscale | 24056945 | 2013 Nov 7 |
| Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide | Turlington, Mark; Noetzel, Meredith J; Chun, Aspen; Zhou, Ya; Gogliotti, Rocco D; Nguyen, Elizabeth D; Gregory, Karen J; Vinson, Paige N; Rook, Jerri M; Gogi, Kiran K; Xiang, Zixiu; Bridges, Thomas M; Daniels, J Scott; Jones, Carrie; Niswender, Colleen M; | Journal of medicinal chemistry | 24050755 | 2013 Oct 24 |
| Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders. | NULL | Drug discovery today. Technologies | 24050278 | 2013 |
| Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. | Ljosa, Vebjorn; Caie, Peter D; Ter Horst, Rob; Sokolnicki, Katherine L; Jenkins, Emma L; Daya, Sandeep; Roberts, Mark E; Jones, Thouis R; Singh, Shantanu; Genovesio, Auguste; Clemons, Paul A; Carragher, Neil O; Carpenter, Anne E | Journal of biomolecular screening | 24045582 | 2013 Dec |
| Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. | Storaska, Andrew J; Mei, Jian P; Wu, Meng; Li, Min; Wade, Susan M; Blazer, Levi L; Sjogren, Benita; Hopkins, Corey R; Lindsley, Craig W; Lin, Zhihong; Babcock, Joseph J; McManus, Owen B; Neubig, Richard R | Cellular signalling | 24041654 | 2013 Dec |
| Identification of Potent and Selective Diphenylpropanamide RORýý Inhibitors. | Huh, Jun R; Englund, Erika E; Wang, Hang; Huang, Ruili; Huang, Pengxiang; Rastinejad, Fraydoon; Inglese, James; Austin, Christopher P; Johnson, Ronald L; Huang, Wenwei; Littman, Dan R | ACS medicinal chemistry letters | 24040486 | 2013 Jan 10 |
| A general, enantioselective synthesis of ýý- and ýý-fluoroamines. | O'Reilly, Matthew C; Lindsley, Craig W | Tetrahedron letters | 24039308 | 2013 Jul 10 |
| Nuclear magnetic resonance at the picomole level of a DNA adduct. | Kautz, Roger; Wang, Poguang; Giese, Roger W | Chemical research in toxicology | 24028148 | 2013 Oct 21 |
| A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In vitro and In vivo. | Abulwerdi, Fardokht; Liao, Chenzhong; Liu, Meilan; Azmi, Asfar S; Aboukameel, Amro; Mady, Ahmed Sa; Gulappa, Thippeswamy; Cierpicki, Tomasz; Owens, Scott; Zhang, Tao; Sun, Duxin; Stuckey, Jeanne A; Mohammad, Ramzi M; Nikolovska-Coleska, Zaneta | Molecular cancer therapeutics | 24019208 | 2013 Sep 9 |
| Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. | Rosenthal, Andrew S; Dexheimer, Thomas S; Gileadi, Opher; Nguyen, Giang H; Chu, Wai Kit; Hickson, Ian D; Jadhav, Ajit; Simeonov, Anton; Maloney, David J | Bioorganic & medicinal chemistry letters | 24012121 | 2013 Oct 15 |
| Amphiphilic suramin dissolves Matrigel, causing an 'inhibition' artefact within in vitro angiogenesis assays. | Prigozhina, Natalie L; Heisel, Andrew J; Seldeen, Jordan R; Cosford, Nicholas D P; Price, Jeffrey H | International journal of experimental pathology | 23998420 | 2013 Dec |
| Size and crystallinity in protein-templated inorganic nanoparticles. | Jolley, Craig C; Uchida, Masaki; Reichhardt, Courtney; Harrington, Richard; Kang, Sebyung; Klem, Michael T; Parise, John B; Douglas, Trevor | Chemistry of materials : a publication of the American Chemical Society | 23997427 | 2010 Aug 24 |
| Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade. | Gunawan, Steven; Hulme, Christopher | Tetrahedron letters | 23997316 | 2013 Aug 14 |
| A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia. | Singh, Harpreet; Shelat, Anang A; Singh, Amandeep; Boulos, Nidal; Williams, Richard T; Guy, R Kiplin | Journal of biomolecular screening | 23989453 | 2014 Jan |
| Identification of Inhibitors of Triacylglyceride Accumulation in Muscle Cells: Comparing HTS Results from 1536-Well Plate-Based and High-Content Platforms. | Sugarman, Eliot; Koo, Ada; Suyama, Eigo; Ruidiaz, Manuel E; Heynen-Genel, Susanne; Nguyen, Kevin H; Vasile, Stefan; Soundarapandian, Mangala M; Vega, Rick B; Kelly, Daniel P; Smith, Layton H; Malany, Siobhan | Journal of biomolecular screening | 23989452 | 2014 Jan |
| A High-Voltage Integrated Circuit Engine for a Dielectrophoresis-based Programmable Micro-Fluidic Processor. | Current, K Wayne; Yuk, Kelvin; McConaghy, Charles; Gascoyne, Peter R C; Schwartz, Jon A; Vykoukal, Jody V; Andrews, Craig | Proceedings ... International Conference on MEMS, NANO, and Smart Systems. International Conference on MEMS, NANO, and Smart Systems | 23989241 | 2005 Jul 24 |
| Spectral bounds on plasmon resonances for Ag and Au prolate and oblate nanospheroids. | Norton, Stephen J; Vo-Dinh, Tuan | Journal of nanophotonics | 23977404 | 2008 Sep 26 |
| Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization. | Khoury, Christopher G; Vo-Dinh, Tuan | The journal of physical chemistry. C, Nanomaterials and interfaces | 23977403 | 2008 |
| Assessing the Location of Surface Plasmons Over Nanotriangle and Nanohole Arrays of Different Size and Periodicity. | Correia-Ledo, Debby; Gibson, Kirsty F; Dhawan, Anuj; Couture, Maxime; Vo-Dinh, Tuan; Graham, Duncan; Masson, Jean-Francois | The journal of physical chemistry. C, Nanomaterials and interfaces | 23977402 | 2012 Mar 29 |
| Theoretical Simulation and Focused Ion Beam Fabrication of Gold Nanostructures For Surface-Enhanced Raman Scattering (SERS). | Dhawan, Anuj; Gerhold, Michael; Vo-Dinh, Tuan | Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences | 23976888 | 2007 Dec |
| Plasmon Resonances of Nanoshells of Spheroidal Shape. | Norton, Stephen J; Vo-Dinh, Tuan | IEEE transactions on nanotechnology | 23976876 | 2007 |
| FIB Fabrication of Metallic Nanostructures on End-Faces of Optical Fibers for Chemical Sensing Applications. | Dhawan, A; Muth, J F; Leonard, D N; Gerhold, M D; Gleeson, J; Vo-Dinh, T; Russell, P E | Journal of vacuum science & technology. B, Microelectronics and nanometer structures : processing, measurement, and phenomena : an official journal of the American Vacuum Society | 23976838 | 2008 |
| Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles. | Arnold, David M; Laporte, Matthew G; Anderson, Shelby M; Wipf, Peter | Tetrahedron | 23976798 | 2013 Sep 9 |
| Small-molecule antagonists of melanopsin-mediated phototransduction. | Jones, Kenneth A; Hatori, Megumi; Mure, Ludovic S; Bramley, Jayne R; Artymyshyn, Roman; Hong, Sang-Phyo; Marzabadi, Mohammad; Zhong, Huailing; Sprouse, Jeffrey; Zhu, Quansheng; Hartwick, Andrew T E; Sollars, Patricia J; Pickard, Gary E; Panda, Satchidanan | Nature chemical biology | 23974117 | 2013 Oct |
| On the Nonnegative Rank of Euclidean Distance Matrices. | Lin, Matthew M; Chu, Moody T | Linear algebra and its applications | 23966751 | 2010 Sep 1 |
| Parameter Reconstruction of Vibration Systems from Partial Eigeninformation. | Dong, Bo; Lin, Matthew M; Chu, Moody T | Journal of sound and vibration | 23966750 | 2009 Nov 13 |
| Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions. | Nguyen, Huy H; Palazzo, Teresa A; Kurth, Mark J | Organic letters | 23961714 | 2013 Sep 6 |
| Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues. | Schulte, Michael L; Turlington, Mark L; Phatak, Sharangdhar S; Harp, Joel M; Stauffer, Shaun R; Lindsley, Craig W | Chemistry (Weinheim an der Bergstrasse, Germany) | 23956045 | 2013 Aug 16 |
| Metabolic imaging of patients with prostate cancer using hyperpolarized [1-ýýýýC]pyruvate. | Nelson, Sarah J; Kurhanewicz, John; Vigneron, Daniel B; Larson, Peder E Z; Harzstark, Andrea L; Ferrone, Marcus; van Criekinge, Mark; Chang, Jose W; Bok, Robert; Park, Ilwoo; Reed, Galen; Carvajal, Lucas; Small, Eric J; Munster, Pamela; Weinberg, Vivian K | Science translational medicine | 23946197 | 2013 Aug 14 |
| VirD: a virion display array for profiling functional membrane proteins. | Hu, Shaohui; Feng, Yingzhu; Henson, Brandon; Wang, Bochu; Huang, Xiaofang; Li, Min; Desai, Prashant; Zhu, Heng | Analytical chemistry | 23941274 | 2013 Sep 3 |
| Integrated analysis of drug-induced gene expression profiles predicts novel hERG inhibitors. | Babcock, Joseph J; Du, Fang; Xu, Kaiping; Wheelan, Sarah J; Li, Min | PloS one | 23936032 | 2013 |
| Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. | Deng, Huayun; Sun, Haiyan; Fang, Ye | Journal of pharmacological and toxicological methods | 23933114 | 2013 Nov-Dec |
| Quantitative affinity electrophoresis of RNA-small molecule interactions by cross-linking the ligand to acrylamide. | Boodram, Sherry N; McCann, Lucas C; Organ, Michael G; Johnson, Philip E | Analytical biochemistry | 23928050 | 2013 Nov 15 |
| Rapid parallel flow cytometry assays of active GTPases using effector beads. | Buranda, Tione; Basuray, Soumik; Swanson, Scarlett; Agola, Jacob; Bondu, Virginie; Wandinger-Ness, Angela | Analytical biochemistry | 23928044 | 2013 Aug 6 |
| Spiro Fused Diterpene-Indole Alkaloids from a Creek-Bottom-Derived Aspergillus terreus. | Cai, Shengxin; Du, Lin; Gerea, Alexandra L; King, Jarrod B; You, Jianlan; Cichewicz, Robert H | Organic letters | 23924243 | 2013 Aug 16 |
| Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. | Ramadhar, Timothy R; Beemelmanns, Christine; Currie, Cameron R; Clardy, Jon | The Journal of antibiotics | 23921819 | 2014 Jan |
| Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. | Ramos-Hunter, Susan J; Engers, Darren W; Kaufmann, Kristian; Du, Yu; Lindsley, Craig W; Weaver, C David; Sulikowski, Gary A | Bioorganic & medicinal chemistry letters | 23916258 | 2013 Sep 15 |
| Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. | Montaser, Rana; Paul, Valerie J; Luesch, Hendrik | Organic letters | 23915229 | 2013 Aug 16 |
| Bifunctional building blocks in the Ugi-azide condensation reaction: a general strategy toward exploration of new molecular diversity. | Gunawan, Steven; Hulme, Christopher | Organic & biomolecular chemistry | 23912086 | 2013 Sep 28 |
| A highly specific cell-based high-throughput screening assay for ligands of cyclic adenosine monophosphate receptor protein in gram-negative bacteria. | Wang, Hongxia; Silva, Anisia J; Rasmussen, Lynn; White, E Lucile; Benitez, Jorge A | Assay and drug development technologies | 23906348 | 2013 Jul |
| A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors. | Du, Yuhong; Fu, Robert W; Lou, Bin; Zhao, Jing; Qui, Min; Khuri, Fadlo R; Fu, Haian | Assay and drug development technologies | 23906346 | 2013 Jul |
| Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model. | Grant, Sarah Schmidt; Kawate, Tomohiko; Nag, Partha P; Silvis, Melanie R; Gordon, Katherine; Stanley, Sarah A; Kazyanskaya, Edward; Nietupski, Raymond; Golas, Aaron; Fitzgerald, Michael; Cho, Sanghyun; Franzblau, Scott G; Hung, Deborah T | ACS chemical biology | 23898841 | 2013 Oct 18 |
| A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. | Stallforth, Pierre; Brock, Debra A; Cantley, Alexandra M; Tian, Xiangjun; Queller, David C; Strassmann, Joan E; Clardy, Jon | Proceedings of the National Academy of Sciences of the United States of America | 23898207 | 2013 Sep 3 |
| NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41. | Gochin, Miriam; Whitby, Landon R; Phillips, Aaron H; Boger, Dale L | Journal of computer-aided molecular design | 23893342 | 2013 Jul |
| Emerging trends in the discovery of natural product antibacterials. | Bologa, Cristian G; Ursu, Oleg; Oprea, Tudor I; Melancon 3rd, Charles E; Tegos, George P | Current opinion in pharmacology | 23890825 | 2013 Jul 24 |
| An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins. | Gao, Xue; Jiang, Wei; Jimenez-Oses, Gonzalo; Choi, Moon Seok; Houk, Kendall N; Tang, Yi; Walsh, Christopher T | Chemistry & biology | 23890005 | 2013 Jul 25 |
| pCAP-based peptide substrates: The new tool in the box of tyrosine phosphatase assays. | Stanford, Stephanie M; Krishnamurthy, Divya; Kulkarni, Rhushikesh A; Karver, Caitlin E; Bruenger, Eveline; Walker, Logan M; Ma, Chen-Ting; Chung, Thomas D Y; Sergienko, Eduard; Bottini, Nunzio; Barrios, Amy M | Methods (San Diego, Calif.) | 23886911 | 2013 Jul 22 |
| Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis. | Al-Mestarihi, Ahmad; Romo, Anthony; Liu, Hung-wen; Bachmann, Brian O | Journal of the American Chemical Society | 23885759 | 2013 Aug 7 |
| Analysis of High-Dimensional Structure-Activity Screening Datasets Using the Optimal Bit String Tree. | Zhang, Ke; Hughes-Oliver, Jacqueline M; Young, S Stanley | Technometrics : a journal of statistics for the physical, chemical, and engineering sciences | 23878407 | 2013 |
| Production of ýý-galactosylceramide by a prominent member of the human gut microbiota. | Wieland Brown, Laura C; Penaranda, Cristina; Kashyap, Purna C; Williams, Brianna B; Clardy, Jon; Kronenberg, Mitchell; Sonnenburg, Justin L; Comstock, Laurie E; Bluestone, Jeffrey A; Fischbach, Michael A | PLoS biology | 23874157 | 2013 Jul |
| Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. | Santagata, Sandro; Mendillo, Marc L; Tang, Yun-chi; Subramanian, Aravind; Perley, Casey C; Roche, Stephane P; Wong, Bang; Narayan, Rajiv; Kwon, Hyoungtae; Koeva, Martina; Amon, Angelika; Golub, Todd R; Porco Jr, John A; Whitesell, Luke; Lindquist, Susan | Science (New York, N.Y.) | 23869022 | 2013 Jul 19 |
| Novel diuretic targets. | Denton, Jerod S; Pao, Alan C; Maduke, Merritt | American journal of physiology. Renal physiology | 23863472 | 2013 Oct 1 |
| Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling. | Rahmouni, Souad; Delacroix, Laurence; Liu, Wallace H; Tautz, Lutz | Methods in molecular biology (Clifton, N.J.) | 23860658 | 2013 |
| High-throughput screening for protein tyrosine phosphatase activity modulators. | Tautz, Lutz; Sergienko, Eduard A | Methods in molecular biology (Clifton, N.J.) | 23860657 | 2013 |
| Protein tyrosine phosphatases: structure, function, and implication in human disease. | Tautz, Lutz; Critton, David A; Grotegut, Stefan | Methods in molecular biology (Clifton, N.J.) | 23860656 | 2013 |
| New activity assays for ENPP1 with physiological substrates ATP and ADP. | Ma, Chen-Ting; Sergienko, Eduard A | Methods in molecular biology (Clifton, N.J.) | 23860653 | 2013 |
| Modulators of intestinal alkaline phosphatase. | Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Sergienko, Eduard A | Methods in molecular biology (Clifton, N.J.) | 23860652 | 2013 |
| A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples. | Sergienko, Eduard A; Sun, Qing; Ma, Chen-Ting | Methods in molecular biology (Clifton, N.J.) | 23860649 | 2013 |
| Robotic implementation of assays: tissue-nonspecific alkaline phosphatase (TNAP) case study. | Chung, Thomas D Y | Methods in molecular biology (Clifton, N.J.) | 23860647 | 2013 |
| A sphingosine 1-phosphate receptor 2 selective allosteric agonist. | Satsu, Hideo; Schaeffer, Marie-Therese; Guerrero, Miguel; Saldana, Adrian; Eberhart, Christina; Hodder, Peter; Cayanan, Charmagne; Schurer, Stephan; Bhhatarai, Barun; Roberts, Ed; Rosen, Hugh; Brown, Steven J | Bioorganic & medicinal chemistry | 23849205 | 2013 Sep 1 |
| Integrative chemical-biological read-across approach for chemical hazard classification. | Low, Yen; Sedykh, Alexander; Fourches, Denis; Golbraikh, Alexander; Whelan, Maurice; Rusyn, Ivan; Tropsha, Alexander | Chemical research in toxicology | 23848138 | 2013 Aug 19 |
| Regulation of proteolysis by human deubiquitinating enzymes. | Eletr, Ziad M; Wilkinson, Keith D | Biochimica et biophysica acta | 23845989 | 2013 Jul 9 |
| Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. | Wen, Wandong; Wu, Wenjun; Romaine, Ian M; Kaufmann, Kristian; Du, Yu; Sulikowski, Gary A; Weaver, C David; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 23838260 | 2013 Jun 20 |
| Small-molecule procaspase activators identified using fluorescence polarization. | Vickers, Chris J; Gonzalez-Paez, Gonzalo E; Umotoy, Jeffrey C; Cayanan-Garrett, Charmagne; Brown, Steven J; Wolan, Dennis W | Chembiochem : a European journal of chemical biology | 23836614 | 2013 Aug 19 |
| Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae. | Napper, Andrew D; Motlekar, Nuzhat; de Almeida, Rogerio Alves; Pavitt, Graham D | Current protocols in chemical biology | 23836585 | 2011 Mar 1 |
| Scaling and systems biology for integrating multiple organs-on-a-chip. | Wikswo, John P; Curtis, Erica L; Eagleton, Zachary E; Evans, Brian C; Kole, Ayeeshik; Hofmeister, Lucas H; Matloff, William J | Lab on a chip | 23828456 | 2013 Aug 13 |
| Identification of a ýý-ýý opioid receptor heteromer-biased agonist with antinociceptive activity. | Gomes, Ivone; Fujita, Wakako; Gupta, Achla; Saldanha, Adrian S; Negri, Ana; Pinello, Christine E; Roberts, Edward; Filizola, Marta; Hodder, Peter; Devi, Lakshmi A | Proceedings of the National Academy of Sciences of the United States of America | 23818586 | 2013 Jul 16 |
| CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. | Guo, Juan; Zhou, Yongjin J; Hillwig, Matthew L; Shen, Ye; Yang, Lei; Wang, Yajun; Zhang, Xianan; Liu, Wujun; Peters, Reuben J; Chen, Xiaoya; Zhao, Zongbao K; Huang, Luqi | Proceedings of the National Academy of Sciences of the United States of America | 23812755 | 2013 Jul 16 |
| PPAR*-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons. | Kim, S; Kiyosawa, N; Burgoon, L D; Chang, C C; Zacharewski, T R | The Journal of steroid biochemistry and molecular biology | 23811191 | 2013 Nov |
| Allokutzneria multivorans sp. nov., an actinomycete isolated from soil. | Cao, Yan-Ru; Chen, Xiu; Jiang, Yi; Wang, Li-Song; Jiang, Cheng-Lin | International journal of systematic and evolutionary microbiology | 23811139 | 2013 Nov |
| Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas. | Yang, Miao; Odelberg, Shannon J; Tong, Zongzhong; Li, Dean Y; Looper, Ryan E | Tetrahedron | 23807819 | 2013 Jul 8 |
| Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. | Vatansever, Fatma; de Melo, Wanessa C M A; Avci, Pinar; Vecchio, Daniela; Sadasivam, Magesh; Gupta, Asheesh; Chandran, Rakkiyappan; Karimi, Mahdi; Parizotto, Nivaldo A; Yin, Rui; Tegos, George P; Hamblin, Michael R | FEMS microbiology reviews | 23802986 | 2013 Nov |
| The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. | Li, Ping; Chen, Zhuxi; Xu, Haiyan; Sun, Haifeng; Li, Hao; Liu, Hong; Yang, Huaiyu; Gao, Zhaobing; Jiang, Hualiang; Li, Min | Cell research | 23797855 | 2013 Sep |
| Picking sides: Distinct roles for CYP76M6 and -8 in rice oryzalexin biosynthesis. | Wu, Yisheng; Wang, Qiang; Hillwig, Matthew L; Peters, Reuben J | The Biochemical journal | 23795884 | 2013 Jun 25 |
| Characterisation of polymer shelled microbubbles in wall less flow phantom using high frequency ultrasound and video microscopy. | Chitnis, P V; Lee, P; Dayton, P A; Mamou, J; Ketterling, J A | Bubble science engineering and technology | 23795208 | 2011 Nov 1 |
| A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. | Zhao, Xiuli; Tang, Zongxiang; Zhang, Hongkang; Atianjoh, Fidelis E; Zhao, Jian-Yuan; Liang, Lingli; Wang, Wei; Guan, Xiaowei; Kao, Sheng-Chin; Tiwari, Vinod; Gao, Yong-Jing; Hoffman, Paul N; Cui, Hengmi; Li, Min; Dong, Xinzhong; Tao, Yuan-Xiang | Nature neuroscience | 23792947 | 2013 Aug |
| Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics. | Wang, Hsin-Neng; Fales, Andrew M; Zaas, Aimee K; Woods, Christopher W; Burke, Thomas; Ginsburg, Geoffrey S; Vo-Dinh, Tuan | Analytica chimica acta | 23790305 | 2013 Jul 5 |
| Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. | Pinilla, Clemencia; Edwards, Bruce S; Appel, Jon R; Yates-Gibbins, Tina; Giulianotti, Marc A; Medina-Franco, Jose L; Young, Susan M; Santos, Radleigh G; Sklar, Larry A; Houghten, Richard A | Molecular pharmacology | 23788657 | 2013 Sep |
| In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes. | McAnally, Danielle; Vicchiarelli, Michael; Siddiquee, Khandaker; Smith, Layton H | Current protocols in chemical biology | 23788556 | 2012 Dec 1 |
| Profiling protein methylation with cofactor analog containing terminal alkyne functionality. | Blum, Gil; Bothwell, Ian R; Islam, Kabirul; Luo, Minkui | Current protocols in chemical biology | 23788324 | 2013 Mar 1 |
| Development of highly selective casein kinase 1ýý/1ýý (CK1ýý/ýý) inhibitors with potent antiproliferative properties. | Bibian, Mathieu; Rahaim, Ronald J; Choi, Jun Yong; Noguchi, Yoshihiko; Schurer, Stephan; Chen, Weimin; Nakanishi, Shima; Licht, Konstantin; Rosenberg, Laura H; Li, Lin; Feng, Yangbo; Cameron, Michael D; Duckett, Derek R; Cleveland, John L; Roush, William | Bioorganic & medicinal chemistry letters | 23787102 | 2013 Aug 1 |
| 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. | Yeung, J; Apopa, P L; Vesci, J; Stolla, M; Rai, G; Simeonov, A; Jadhav, A; Fernandez-Perez, P; Maloney, D J; Boutaud, O; Holman, T R; Holinstat, M | Thrombosis and haemostasis | 23784669 | 2013 Sep |
| RanGTP and CLASP1 cooperate to position the mitotic spindle. | Bird, Stephen L; Heald, Rebecca; Weis, Karsten | Molecular biology of the cell | 23783028 | 2013 Aug |
| Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets. | Young, Summer E; Duvernay, Matthew T; Schulte, Michael L; Lindsley, Craig W; Hamm, Heidi E | PloS one | 23776495 | 2013 |
| In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. | Wang, Rui; Mason, Daniel E; Choe, Keith P; Lewin, Alfred S; Peters, Eric C; Luesch, Hendrik | ACS chemical biology | 23773140 | 2013 Aug 16 |
| Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays. | Landry, James P; Fei, Yiyan; Zhu, Xiangdong; Ke, Yaohuang; Yu, Guoliang; Lee, Pierre | Assay and drug development technologies | 23772553 | 2013 Jun |
| Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. | Xiao, Jingbo; Huang, Zaohua; Chen, Catherine Z; Agoulnik, Irina U; Southall, Noel; Hu, Xin; Jones, Raisa E; Ferrer, Marc; Zheng, Wei; Agoulnik, Alexander I; Marugan, Juan J | Nature communications | 23764525 | 2013 |
| Various cyclization scaffolds by a truly Ugi 4-CR. | Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, Alexander | Organic & biomolecular chemistry | 23760036 | 2013 Jun 13 |
| Synthesis of spirocarbamate oxindoles via intramolecular trapping of a ýý-silyl carbocation by an N-Boc group. | Shupe, Benjamin H; Allen, Emily E; MacDonald, Jacob P; Wilson, Sean O; Franz, Annaliese K | Organic letters | 23758331 | 2013 Jul 5 |
| Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. | Yu, Yi-Yun; Bi, Lei; Georg, Gunda I | The Journal of organic chemistry | 23750615 | 2013 Jun 21 |
| Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. | Ardecky, Robert J; Welsh, Kate; Finlay, Darren; Lee, Pooi San; Gonzalez-Lopez, Marcos; Ganji, Santhi Reddy; Ravanan, Palaniyandi; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D P | Bioorganic & medicinal chemistry letters | 23743278 | 2013 Jul 15 |
| Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. | De, Subhasis; Chen, Lu; Zhang, Shuxing; Gilbertson, Scott R | ACS combinatorial science | 23742807 | 2013 Jul 8 |
| A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress. | Wang, Hongxia; Zhang, Li; Silva, Anisia J; Benitez, Jorge A | Antimicrobial agents and chemotherapy | 23733460 | 2013 Aug |
| ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. | Kaufmann, Kristian; Romaine, Ian; Days, Emily; Pascual, Conrado; Malik, Adam; Yang, Liya; Zou, Bende; Du, Yu; Sliwoski, Greg; Morrison, Ryan D; Denton, Jerod; Niswender, Colleen M; Daniels, J Scott; Sulikowski, Gary A; Xie, Xinmin Simon; Lindsley, Craig W | ACS chemical neuroscience | 23730969 | 2013 Sep 18 |
| The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. | Floyd, Scott R; Pacold, Michael E; Huang, Qiuying; Clarke, Scott M; Lam, Fred C; Cannell, Ian G; Bryson, Bryan D; Rameseder, Jonathan; Lee, Michael J; Blake, Emily J; Fydrych, Anna; Ho, Richard; Greenberger, Benjamin A; Chen, Grace C; Maffa, Amanda; Del R | Nature | 23728299 | 2013 Jun 13 |
| Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. | Scott, Sarah A; Xiang, Yun; Mathews, Thomas P; Cho, Hyekyung P; Myers, David S; Armstrong, Michelle D; Tallman, Keri A; O'Reilly, Matthew C; Lindsley, Craig W; Brown, H Alex | The Journal of biological chemistry | 23723068 | 2013 Jul 12 |
| The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors. | Santos, Radleigh G; Appel, Jon R; Giulianotti, Marc A; Edwards, Bruce S; Sklar, Larry A; Houghten, Richard A; Pinilla, Clemencia | Molecules (Basel, Switzerland) | 23722730 | 2013 |
| Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip. | Ngo, Hoan Thanh; Wang, Hsin-Neng; Fales, Andrew M; Vo-Dinh, Tuan | Analytical chemistry | 23718777 | 2013 Jul 2 |
| Discovery of (R)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu3 Selective and CNS Penetrant Negative Allosteric Modulator (NAM). | Wenthur, Cody J; Morrison, Ryan; Felts, Andrew S; Smith, Katrina A; Engers, Julie L; Byers, Frank W; Daniels, J Scott; Emmitte, Kyle A; Conn, P Jeffrey; Lindsley, Craig W | Journal of medicinal chemistry | 23718281 | 2013 Jun 27 |
| Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry. | Xu, Zhigang; De Moliner, Fabio; Cappelli, Alexandra P; Hulme, Christopher | Organic letters | 23718233 | 2013 Jun 7 |
| Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase. | Harris, Michael T; Walker, Dawn M; Drew, Mark E; Mitchell, William G; Dao, Kevin; Schroeder, Chad E; Flaherty, Daniel P; Weiner, Warren S; Golden, Jennifer E; Morris, James C | Antimicrobial agents and chemotherapy | 23716053 | 2013 Aug |
| Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. | Rateb, Mostafa E; Yu, Zhiguo; Yan, Yijun; Yang, Dong; Huang, Tingting; Vodanovic-Jankovic, Sanja; Kron, Michael A; Shen, Ben | The Journal of antibiotics | 23715040 | 2013 May 29 |
| Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. | Zhang, Liying; Sedykh, Alexander; Tripathi, Ashutosh; Zhu, Hao; Afantitis, Antreas; Mouchlis, Varnavas D; Melagraki, Georgia; Rusyn, Ivan; Tropsha, Alexander | Toxicology and applied pharmacology | 23707773 | 2013 Oct 1 |
| Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches. | Medina-Franco, Jose L; Edwards, Bruce S; Pinilla, Clemencia; Appel, Jon R; Giulianotti, Marc A; Santos, Radleigh G; Yongye, Austin B; Sklar, Larry A; Houghten, Richard A | Journal of chemical information and modeling | 23705689 | 2013 Jun 24 |
| Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. | Sweeney, Noreena L; Shadrick, William R; Mukherjee, Sourav; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David N | The Journal of biological chemistry | 23703611 | 2013 Jul 5 |
| Multicomponent Assembly Processes for the Synthesis of Diverse Yohimbine and Corynanthe Alkaloid Analogues. | Granger, Brett A; Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen F | ACS combinatorial science | 23697376 | 2013 Jun 4 |
| Predicting drug-induced QT prolongation effects using multi-view learning. | Zhang, Jintao; Huan, Jun | IEEE transactions on nanobioscience | 23694701 | 2013 Sep |
| Inside job: ligand-receptor pharmacology beneath the plasma membrane. | Babcock, Joseph J; Li, Min | Acta pharmacologica Sinica | 23685953 | 2013 Jul |
| Synthesis of a Library of "Lead-Like" ýý-Lactams by a One Pot, Four-Component Reaction. | Martin, Kevin S; Di Maso, Michael J; Fettinger, James C; Shaw, Jared Thomas | ACS combinatorial science | 23682712 | 2013 May 17 |
| Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology. | Watson, Venita Gresham; Drake, Katherine M; Peng, Yu; Napper, Andrew D | Assay and drug development technologies | 23679849 | 2013 May |
| Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. | Lu, Jiuyi; Chen, Minyong; Ren, Xiu-Rong; Wang, Jiangbo; Lyerly, H Kim; Barak, Larry; Chen, Wei | PloS one | 23671675 | 2013 |
| Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine. | Blum, Gil; Islam, Kabirul; Luo, Minkui | Current protocols in chemical biology | 23667794 | 2013 Mar 1 |
| Using Azido Analogue of S-Adenosyl-L-methionine for Bioorthogonal Profiling of Protein Methylation (BPPM). | Blum, Gil; Islam, Kabirul; Luo, Minkui | Current protocols in chemical biology | 23667794 | 2013 Mar |
| Mechanism-based corrector combination restores ýýF508-CFTR folding and function. | Okiyoneda, Tsukasa; Veit, Guido; Dekkers, Johanna F; Bagdany, Miklos; Soya, Naoto; Xu, Haijin; Roldan, Ariel; Verkman, Alan S; Kurth, Mark; Simon, Agnes; Hegedus, Tamas; Beekman, Jeffrey M; Lukacs, Gergely L | Nature chemical biology | 23666117 | 2013 Jul |
| New route to the ergoline skeleton via cyclization of 4-unsubstituted indoles. | Burley, Scott D; Lam, Vicky V; Lakner, Frederick J; Bergdahl, B Mikael; Parker, Matthew A | Organic letters | 23659323 | 2013 Jun 7 |
| A rapid membrane potential assay to monitor CFTR function and inhibition. | Maitra, Rangan; Sivashanmugam, Perumal; Warner, Keith | Journal of biomolecular screening | 23653393 | 2013 Oct |
| LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. | Xu, Wei; Chooi, Yit-Heng; Choi, Jin W; Li, Shuang; Vederas, John C; Da Silva, Nancy A; Tang, Yi | Angewandte Chemie (International ed. in English) | 23653178 | 2013 Jun 17 |
| Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. | Zhou, Pingzheng; Yu, Haibo; Gu, Min; Nan, Fa-jun; Gao, Zhaobing; Li, Min | Proceedings of the National Academy of Sciences of the United States of America | 23650395 | 2013 May 21 |
| Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. | Yu, Haibo; Lin, Zhihong; Mattmann, Margrith E; Zou, Beiyan; Terrenoire, Cecile; Zhang, Hongkang; Wu, Meng; McManus, Owen B; Kass, Robert S; Lindsley, Craig W; Hopkins, Corey R; Li, Min | Proceedings of the National Academy of Sciences of the United States of America | 23650380 | 2013 May 21 |
| Tricycles by a new ugi variation and pictet-spengler reaction in one pot. | Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, Alexander | Chemistry (Weinheim an der Bergstrasse, Germany) | 23649922 | 2013 Jun 17 |
| Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. | Coombs, Thomas C; Tanega, Cordelle; Shen, Min; Wang, Jenna L; Auld, Douglas S; Gerritz, Samuel W; Schoenen, Frank J; Thomas, Craig J; Aube, Jeffrey | Bioorganic & medicinal chemistry letters | 23642479 | 2013 Jun 15 |
| High-Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor. | Conn, P Michael; Smith, Emery; Hodder, Peter; Janovick, Jo Ann; Smithson, David C | Journal of biomolecular screening | 23640875 | 2013 May 2 |
| Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN | Engers, Darren W; Frist, Audrey Y; Lindsley, Craig W; Hong, Charles C; Hopkins, Corey R | Bioorganic & medicinal chemistry letters | 23639540 | 2013 Jun 1 |
| An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. | Leung, Chi K; Wang, Ying; Malany, Siobhan; Deonarine, Andrew; Nguyen, Kevin; Vasile, Stefan; Choe, Keith P | PloS one | 23637990 | 2013 |
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| Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation. | Panarese, Joseph D; Konkol, Leah C; Berry, Cynthia B; Bates, Brittney S; Aldrich, Leslie N; Lindsley, Craig W | Tetrahedron letters | 23606772 | 2013 May 1 |
| A small molecule inhibitor of redox-regulated protein translocation into mitochondria. | Dabir, Deepa V; Hasson, Samuel A; Setoguchi, Kiyoko; Johnson, Meghan E; Wongkongkathep, Piriya; Douglas, Colin J; Zimmerman, Johannes; Damoiseaux, Robert; Teitell, Michael A; Koehler, Carla M | Developmental cell | 23597483 | 2013 Apr 15 |
| Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. | Cheng, Bokun; Cao, Shugeng; Vasquez, Victor; Annamalai, Thirunavukkarasu; Tamayo-Castillo, Giselle; Clardy, Jon; Tse-Dinh, Yuk-Ching | PloS one | 23593306 | 2013 |
| An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening. | Thomas, Pei W; Spicer, Timothy; Cammarata, Michael; Brodbelt, Jennifer S; Hodder, Peter; Fast, Walter | Bioorganic & medicinal chemistry | 23591260 | 2013 Jun 1 |
| A small molecule inhibitor of fungal histone acetyltransferase Rtt109. | Lopes da Rosa, Jessica; Bajaj, Vineeta; Spoonamore, James; Kaufman, Paul D | Bioorganic & medicinal chemistry letters | 23587423 | 2013 May 15 |
| An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. | Mulrooney, Carol A; Lahr, David L; Quintin, Michael J; Youngsaye, Willmen; Moccia, Dennis; Asiedu, Jacob K; Mulligan, Evan L; Akella, Lakshmi B; Marcaurelle, Lisa A; Montgomery, Philip; Bittker, Joshua A; Clemons, Paul A; Brudz, Stephen; Dandapani, Sivara | Journal of computer-aided molecular design | 23585218 | 2013 May |
| Neural progenitor cells labeling with microbubble contrast agent for ultrasound imaging in vivo. | Cui, Wenjin; Tavri, Sidhartha; Benchimol, Michael J; Itani, Malak; Olson, Emilia S; Zhang, Hong; Decyk, Marika; Ramirez, Rosemarie G; Barback, Christopher V; Kono, Yuko; Mattrey, Robert F | Biomaterials | 23578557 | 2013 Jul |
| Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. | Karapetyan, Yervand Eduard; Sferrazza, Gian Franco; Zhou, Minghai; Ottenberg, Gregory; Spicer, Timothy; Chase, Peter; Fallahi, Mohammad; Hodder, Peter; Weissmann, Charles; Lasmezas, Corinne Ida | Proceedings of the National Academy of Sciences of the United States of America | 23576755 | 2013 Apr 23 |
| The use of pseudo-equilibrium constant affords improved QSAR models of human plasma protein binding. | Zhu, Xiang-Wei; Sedykh, Alexander; Zhu, Hao; Liu, Shu-Shen; Tropsha, Alexander | Pharmaceutical research | 23568522 | 2013 Jul |
| Discovery of BRM Targeted Therapies: Novel Reactivation of an Anti-cancer Gene. | Gramling, Sarah; Reisman, David | Letters in drug design & discovery | 23565070 | 2011 Jan 1 |
| Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. | Hu, Longqin; Magesh, Sadagopan; Chen, Lin; Wang, Lili; Lewis, Timothy A; Chen, Yu; Khodier, Carol; Inoyama, Daigo; Beamer, Lesa J; Emge, Thomas J; Shen, Jian; Kerrigan, John E; Kong, Ah-Ng Tony; Dandapani, Sivaraman; Palmer, Michelle; Schreiber, Stuart L; | Bioorganic & medicinal chemistry letters | 23562243 | 2013 May 15 |
| Discovery of ML326: The first sub-micromolar, selective M5 PAM. | Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Scott Daniels, J; Jeffrey Conn, P; Wood, Michael R; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 23562060 | 2013 May 15 |
| Ugi/Robinson-Gabriel reactions directed toward the synthesis of 2,4,5-trisubstituted oxazoles. | Shaw, Arthur Y; Xu, Zhigang; Hulme, Christopher | Tetrahedron letters | 23559684 | 2012 Apr 11 |
| Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones. | Coffman, Keith C; Palazzo, Teresa A; Hartley, Timothy P; Fettinger, James C; Tantillo, Dean J; Kurth, Mark J | Organic letters | 23557405 | 2013 Apr 19 |
| Synthesis and Characterization of Germanium Coordination Compounds for Production of Germanium Nanomaterials. | Boyle, Timothy J; Tribby, Louis J; Ottley, Leigh Anna M; Han, Sang M | European journal of inorganic chemistry | 23555180 | 2009 Dec 1 |
| Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol. | Hutt, Oliver E; Doan, Trinh L; Georg, Gunda I | Organic letters | 23530630 | 2013 Apr 5 |
| Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C-H activation. | Yu, Yi-Yun; Georg, Gunda I | Chemical communications (Cambridge, England) | 23529083 | 2013 May 7 |
| Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. | Rosen, Hugh; Stevens, Raymond C; Hanson, Michael; Roberts, Edward; Oldstone, Michael B A | Annual review of biochemistry | 23527695 | 2013 |
| Intermolecular C-O Addition of Carboxylic Acids to Arynes: Synthesis of o-Hydroxyaryl Ketones, Xanthones, 4-Chromanones, and Flavones. | Dubrovskiy, Anton V; Larock, Richard C | Tetrahedron | 23520410 | 2013 Apr 1 |
| Solution-phase parallel synthesis of a multisubstituted cyclic imidate library. | Mehta, Saurabh; Waldo, Jesse P; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C | ACS combinatorial science | 23514214 | 2013 May 13 |
| Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. | Dranchak P, MacArthur R, Guha R, Zuercher WJ, Drewry DH, Auld DS, Inglese J. | PLoS One | 23505445 | 2013 Mar 7 |
| A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families. | De Moliner, Fabio; Hulme, Christopher | Tetrahedron letters | 23504533 | 2012 Oct 24 |
| Histological image classification using biologically interpretable shape-based features. | Kothari, Sonal; Phan, John H; Young, Andrew N; Wang, May D | BMC medical imaging | 23497380 | 2013 |
| Applications of fiber-optics-based nanosensors to drug discovery. | Vo-Dinh, Tuan; Scaffidi, Jonathan; Gregas, Molly; Zhang, Yan; Seewaldt, Victoria | Expert opinion on drug discovery | 23496274 | 2009 Aug |
| Molecular sentinel-on-chip for SERS-based biosensing. | Wang, Hsin-Neng; Dhawan, Anuj; Du, Yan; Batchelor, Dale; Leonard, Donovan N; Misra, Veena; Vo-Dinh, Tuan | Physical chemistry chemical physics : PCCP | 23493773 | 2013 Apr 28 |
| High-Throughput RT-PCR for small-molecule screening assays. | Bittker, Joshua A | Current protocols in chemical biology | 23487248 | 2012 Mar 1 |
| Identification of small molecules that inhibit the interaction of TEM8 with anthrax protective antigen using a FRET assay. | Cryan, Lorna M; Habeshian, Kaiane A; Caldwell, Thomas P; Morris, Meredith T; Ackroyd, P Christine; Christensen, Kenneth A; Rogers, Michael S | Journal of biomolecular screening | 23479355 | 2013 Jul |
| Bioluminescent assays for cytochrome P450 enzymes. | Auld DS, Veith H, Cali JJ. | Methods Mol Biol | 23475663 | 2013 |
| Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes. | Dubrovskiy, Anton V; Jain, Prashi; Shi, Feng; Lushington, Gerald H; Santini, Conrad; Porubsky, Patrick; Larock, Richard C | ACS combinatorial science | 23472819 | 2013 Apr 8 |
| Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters. | Strouse, J Jacob; Ivnitski-Steele, Irena; Waller, Anna; Young, Susan M; Perez, Dominique; Evangelisti, Annette M; Ursu, Oleg; Bologa, Cristian G; Carter, Mark B; Salas, Virginia M; Tegos, George; Larson, Richard S; Oprea, Tudor I; Edwards, Bruce S; Sklar, | Analytical biochemistry | 23470221 | 2013 Jun 1 |
| The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide. | Cabarcas SM, Sun L, Mathews L, Thomas S, Zhang X, Farrar WL. | Pancreas | 23462327 | 2013 Jul |
| Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. | Sun, Hongmao; Veith, Henrike; Xia, Menghang; Austin, Christopher P; Tice, Raymond R; Huang, Ruili | Molecular informatics | 23459712 | 2012 Nov 1 |
| Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist. | Chen, Haijun; Ding, Chunyong; Wild, Christopher; Liu, Huiling; Wang, Tianzhi; White, Mark A; Cheng, Xiaodong; Zhou, Jia | Tetrahedron letters | 23459418 | 2013 Mar 20 |
| A General, Enantioselective Synthesis of 1-Azabicyclo[m.n.0]alkane Ring Systems. | Senter, Timothy J; Schulte, Michael L; Konkol, Leah C; Wadzinski, Tyler E; Lindsley, Craig W | Tetrahedron letters | 23459400 | 2013 Mar 27 |
| hERG channel function: beyond long QT. | Babcock, Joseph J; Li, Min | Acta pharmacologica Sinica | 23459091 | 2013 Mar |
| Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model. | Chibebe Junior, Jose; Fuchs, Beth B; Sabino, Caetano P; Junqueira, Juliana C; Jorge, Antonio O C; Ribeiro, Martha S; Gilmore, Michael S; Rice, Louis B; Tegos, George P; Hamblin, Michael R; Mylonakis, Eleftherios | PloS one | 23457486 | 2013 |
| EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold. | Jiang, Wei; Cacho, Ralph A; Chiou, Grace; Garg, Neil K; Tang, Yi; Walsh, Christopher T | Journal of the American Chemical Society | 23451921 | 2013 Mar 20 |
| High-Throughput Identification of Promiscuous Inhibitors from Screening Libraries with the Use of a Thiol-Containing Fluorescent Probe. | McCallum, Megan M; Nandhikonda, Premchendar; Temmer, Jonathan J; Eyermann, Charles; Simeonov, Anton; Jadhav, Ajit; Yasgar, Adam; Maloney, David; Arnold, Alexander Leggy | Journal of biomolecular screening | 23446699 | 2013 Feb 27 |
| Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. | O'Reilly, Matthew C; Scott, Sarah A; Brown, Kyle A; Oguin 3rd, Thomas H; Thomas, Paul G; Daniels, J Scott; Morrison, Ryan; Brown, H Alex; Lindsley, Craig W | Journal of medicinal chemistry | 23445448 | 2013 Mar 28 |
| Probing the metabotropic glutamate receptor 5 (mGluýýý) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology. | Gregory, Karen J; Nguyen, Elizabeth D; Reiff, Sean D; Squire, Emma F; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn, P Jeffrey | Molecular pharmacology | 23444015 | 2013 May |
| Developing irreversible inhibitors of the protein kinase cysteinome. | Liu, Qingsong; Sabnis, Yogesh; Zhao, Zheng; Zhang, Tinghu; Buhrlage, Sara J; Jones, Lyn H; Gray, Nathanael S | Chemistry & biology | 23438744 | 2013 Feb 21 |
| Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. | Welsbie, Derek S; Yang, Zhiyong; Ge, Yan; Mitchell, Katherine L; Zhou, Xinrong; Martin, Scott E; Berlinicke, Cynthia A; Hackler Jr, Laszlo; Fuller, John; Fu, Jie; Cao, Li-hui; Han, Bing; Auld, Douglas; Xue, Tian; Hirai, Syu-ichi; Germain, Lucie; Simard-Bisson, Caroline; Blouin, Richard; Nguyen, Judy V; Davis, Chung-ha O; Enke, Raymond A; Boye, Sanford L; Merbs, Shannath L; Marsh-Armstrong, Nicholas; Hauswirth, William W; DiAntonio, Aaron; Nickells, Robert W; Inglese, James; Hanes, Justin; Yau, King-Wai; Quigley, Harry A; Zack, Donald J | Proceedings of the National Academy of Sciences of the United States of America | 23431148 | 2013 Mar 5 |
| Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. | Huang, Gang; Chen, Huabing; Dong, Ying; Luo, Xiuquan; Yu, Haijun; Moore, Zachary; Bey, Erik A; Boothman, David A; Gao, Jinming | Theranostics | 23423156 | 2013 |
| Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule. | Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R | Bioorganic & medicinal chemistry letters | 23416001 | 2013 Mar 15 |
| Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders. | Gregory, Karen J; Noetzel, Meredith J; Niswender, Colleen M | Progress in molecular biology and translational science | 23415092 | 2013 |
| Approaches for probing allosteric interactions at 7 transmembrane spanning receptors. | Klein, Michael T; Vinson, Paige N; Niswender, Colleen M | Progress in molecular biology and translational science | 23415091 | 2013 |
| Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived claisen rearrangements. | McIntosh, John A; Lin, Zhenjian; Tianero, Ma Diarey B; Schmidt, Eric W | ACS chemical biology | 23411099 | 2013 May 17 |
| Synthesis and activity of biomimetic biofilm disruptors. | Bottcher, Thomas; Kolodkin-Gal, Ilana; Kolter, Roberto; Losick, Richard; Clardy, Jon | Journal of the American Chemical Society | 23406351 | 2013 Feb 27 |
| Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. | Germain, Andrew R; Carmody, Leigh C; Nag, Partha P; Morgan, Barbara; Verplank, Lynn; Fernandez, Cristina; Donckele, Etienne; Feng, Yuxiong; Perez, Jose R; Dandapani, Sivaraman; Palmer, Michelle; Lander, Eric S; Gupta, Piyush B; Schreiber, Stuart L; Munoz, | Bioorganic & medicinal chemistry letters | 23403082 | 2013 Mar 15 |
| Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis. | Sivan G, Martin SE, Myers TG, Buehler E, Szymczyk KH, Ormanoglu P, Moss B. | Proc Natl Acad Sci U S A | 23401514 | 2013 Feb 26 |
| A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase. | Chen CZ, Southall N, Galkin A, Lim K, Marugan JJ, Kulakova L, Shinn P, van Leer D, Zheng W, Herzberg O. | Curr Chem Genomics | 23400734 | 2012 |
| Parallel solution-phase synthesis of an adenosine antibiotic analog library. | Moukha-chafiq, Omar; Reynolds, Robert C | ACS combinatorial science | 23398694 | 2013 Mar 11 |
| An end to the myth: there is no drug development pipeline. | Baxter K, Horn E, Gal-Edd N, Zonno K, O'Leary J, Terry PF, Terry SF. | Sci Transl Med | 23390245 | 2013 Feb 6 |
| Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells. | Sherman, Sean P; Pyle, April D | PloS one | 23383009 | 2013 |
| Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. | Hong, Lin; Kenney, S Ray; Phillips, Genevieve K; Simpson, Denise; Schroeder, Chad E; Noth, Julica; Romero, Elsa; Swanson, Scarlett; Waller, Anna; Strouse, J Jacob; Carter, Mark; Chigaev, Alexandre; Ursu, Oleg; Oprea, Tudor; Hjelle, Brian; Golden, Jennifer | The Journal of biological chemistry | 23382385 | 2013 Mar 22 |
| High-throughput screening for small-molecule modulators of inward rectifier potassium channels. | Raphemot, Rene; Weaver, C David; Denton, Jerod S | Journal of visualized experiments : JoVE | 23381507 | 2013 |
| Antibody therapeutics targeting ion channels: are we there yet? | Sun, Han; Li, Min | Acta pharmacologica Sinica | 23381110 | 2013 Feb |
| Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. | Wikswo, John P; Block 3rd, Frank E; Cliffel, David E; Goodwin, Cody R; Marasco, Christina C; Markov, Dmitry A; McLean, David L; McLean, John A; McKenzie, Jennifer R; Reiserer, Ronald S; Samson, Philip C; Schaffer, David K; Seale, Kevin T; Sherrod, Stacy D | IEEE transactions on bio-medical engineering | 23380852 | 2013 Mar |
| Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present). | Zak, Krzysztof; Pecak, Aleksandra; Rys, Barbara; Wladyka, Benedykt; Domling, Alexander; Weber, Lutz; Holak, Tad A; Dubin, Grzegorz | Expert opinion on therapeutic patents | 23374098 | 2013 Apr |
| Feasibility of multiplex quantum dot stain using primary antibodies from four distinct host animals. | Tran, Jonathan K; Hubbard, Elena N; Stokes, Todd H; Moffitt, Richard A; Wang, May D | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | 23367436 | 2012 |
| Scale normalization of histopathological images for batch invariant cancer diagnostic models. | Kothari, Sonal; Phan, John H; Wang, May D | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | 23366904 | 2012 |
| Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. | Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J. | RNA Biol | 23353574 | 2013 Feb |
| Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. | Emert-Sedlak, Lori A; Narute, Purushottam; Shu, Sherry T; Poe, Jerrod A; Shi, Haibin; Yanamala, Naveena; Alvarado, John Jeff; Lazo, John S; Yeh, Joanne I; Johnston, Paul A; Smithgall, Thomas E | Chemistry & biology | 23352142 | 2013 Jan 24 |
| A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. | Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanad Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; Jadhav, Ajit; Gileadi, Opher; Maloney, David J; Simeonov, Anton; Hickson, Ian D | Chemistry & biology | 23352139 | 2013 Jan 24 |
| A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. | Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanad Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; | Chemistry & biology | 23352139 | 2013 Jan 24 |
| Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. | Salvador, Lilibeth A; Taori, Kanchan; Biggs, Jason S; Jakoncic, Jean; Ostrov, David A; Paul, Valerie J; Luesch, Hendrik | Journal of medicinal chemistry | 23350733 | 2013 Feb 14 |
| Effect of virulence factors on the photodynamic inactivation of Cryptococcus neoformans. | Prates, Renato A; Fuchs, Beth Burgwyn; Mizuno, Kazue; Naqvi, Qurat; Kato, Ilka T; Ribeiro, Martha S; Mylonakis, Eleftherios; Tegos, George P; Hamblin, Michael R | PloS one | 23349872 | 2013 |
| A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. | Noetzel, M J; Gregory, K J; Vinson, P N; Manka, J T; Stauffer, S R; Lindsley, C W; Niswender, C M; Xiang, Z; Conn, P J | Molecular pharmacology | 23348500 | 2013 Apr |
| High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. | Titus SA, Southall N, Marugan J, Austin CP, Zheng W. | Curr Chem Genomics | 23346268 | 2012 |
| A fast least-squares algorithm for population inference. | Parry, R Mitchell; Wang, May D | BMC bioinformatics | 23343408 | 2013 |
| Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. | Derewacz, Dagmara K; Goodwin, Cody R; McNees, C Ruth; McLean, John A; Bachmann, Brian O | Proceedings of the National Academy of Sciences of the United States of America | 23341601 | 2013 Feb 5 |
| Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. | Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Richard A, Tice RR, Whelan M, Xia M, Huang R, Austin C, Daston G, Hartung T, Fowle JR 3rd, Wooge W, Tong W, Dix D. | ALTEX | 23338806 | 2013 |
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| Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL pr | Jacobs, Jon; Grum-Tokars, Valerie; Zhou, Ya; Turlington, Mark; Saldanha, S Adrian; Chase, Peter; Eggler, Aimee; Dawson, Eric S; Baez-Santos, Yahira M; Tomar, Sakshi; Mielech, Anna M; Baker, Susan C; Lindsley, Craig W; Hodder, Peter; Mesecar, Andrew; Stauf | Journal of medicinal chemistry | 23231439 | 2013 Jan 24 |
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| A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. | Johnson, Barry C; Pauly, Gary T; Rai, Ganesha; Patel, Disha; Bauman, Joseph D; Baker, Heather L; Das, Kalyan; Schneider, Joel P; Maloney, David J; Arnold, Eddy; Thomas, Craig J; Hughes, Stephen H | Retrovirology | 23217210 | 2012 |
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| A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. | Dobri, Nicoleta; Qin, Qiong; Kong, Jian; Yamamoto, Kazunori; Liu, Zhao; Moiseyev, Gennadiy; Ma, Jian-Xing; Allikmets, Rando; Sparrow, Janet R; Petrukhin, Konstantin | Investigative ophthalmology & visual science | 23211825 | 2013 Jan |
| A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases(). | Mott, Bryan T; Cheng, Ken Chih-Chien; Guha, Rajarshi; Kommer, Valerie P; Williams, David L; Vermeire, Jon J; Cappello, Michael; Maloney, David J; Rai, Ganesha; Jadhav, Ajit; Simeonov, Anton; Inglese, James; Posner, Gary H; Thomas, Craig J | MedChemComm | 23205265 | 2012 Dec |
| Nonomuraea solani sp. nov., an actinomycete isolated from eggplant root (Solanum melongena L.). | Wang, Xiangjing; Zhao, Junwei; Liu, Chongxi; Wang, Jidong; Shen, Yue; Jia, Feiyu; Wang, Liang; Zhang, Ji; Yu, Chao; Xiang, Wensheng | International journal of systematic and evolutionary microbiology | 23203622 | 2013 Jul |
| Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. | Lu, Bin; Lee, Jae; Nie, Xiaobo; Li, Min; Morozov, Yaroslav I; Venkatesh, Sundararajan; Bogenhagen, Daniel F; Temiakov, Dmitry; Suzuki, Carolyn K | Molecular cell | 23201127 | 2013 Jan 10 |
| Further exploration of Mýýý allosteric agonists: subtle structural changes abolish Mýýý allosteric agonism and result in pan-mAChR orthosteric antagonism. | Sheffler, Douglas J; Sevel, Christian; Le, Uyen; Lovell, Kimberly M; Tarr, James C; Carrington, Sheridan J S; Cho, Hyekyung P; Digby, Gregory J; Niswender, Colleen M; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 23200253 | 2013 Jan 1 |
| Quantitative surface-enhanced resonant Raman scattering multiplexing of biocompatible gold nanostars for in vitro and ex vivo detection. | Yuan, Hsiangkuo; Liu, Yang; Fales, Andrew M; Li, You Leo; Liu, Jesse; Vo-Dinh, Tuan | Analytical chemistry | 23194068 | 2013 Jan 2 |
| High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase. | McCoy, Eric S; Lea, Wendy A; Mott, Bryan T; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Zylka, Mark J | Journal of biomolecular screening | 23190738 | 2013 Apr |
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| Genome streamlining and chemical defense in a coral reef symbiosis. | Kwan, Jason C; Donia, Mohamed S; Han, Andrew W; Hirose, Euichi; Haygood, Margo G; Schmidt, Eric W | Proceedings of the National Academy of Sciences of the United States of America | 23185008 | 2012 Dec 11 |
| The Role of Phosphatases in the Initiation of Skeletal Mineralization. | Millan, Jose Luis | Calcified tissue international | 23183786 | 2012 Nov 27 |
| Selenium dioxide-mediated synthesis of ýý-ketoamides from arylglyoxals and secondary amines. | Shaw, Arthur Y; Denning, Christine R; Hulme, Christopher | Tetrahedron letters | 23180891 | 2012 Aug 8 |
| Discovery of a selective Mýýý positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. | Le, Uyen; Melancon, Bruce J; Bridges, Thomas M; Vinson, Paige N; Utley, Thomas J; Lamsal, Atin; Rodriguez, Alice L; Venable, Daryl; Sheffler, Douglas J; Jones, Carrie K; Blobaum, Anna L; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Niswender, Colle | Bioorganic & medicinal chemistry letters | 23177787 | 2013 Jan 1 |
| Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169. | Tarr, James C; Turlington, Mark L; Reid, Paul R; Utley, Thomas J; Sheffler, Douglas J; Cho, Hyekyung P; Klar, Rebecca; Pancani, Tristano; Klein, Michael T; Bridges, Thomas M; Morrison, Ryan D; Blobaum, Anna L; Xiang, Zixui; Daniels, J Scott; Niswender, Co | ACS chemical neuroscience | 23173069 | 2012 Nov 21 |
| The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP. | Pultz, Ingrid Swanson; Christen, Matthias; Kulasekara, Hemantha Don; Kennard, Andrew; Kulasekara, Bridget; Miller, Samuel I | Molecular microbiology | 23163901 | 2012 Dec |
| Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis. | Florian, Amy E; Lepensky, Christopher K; Kwon, Ohyun; Haynes, Mark K; Sklar, Larry A; Zweifach, Adam | Journal of biomolecular screening | 23160568 | 2013 Apr |
| Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. | Bauer, Renato A; Wenderski, Todd A; Tan, Derek S | Nature chemical biology | 23160003 | 2013 Jan |
| Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression. | Lee, Gabsang; Ramirez, Christina N; Kim, Hyesoo; Zeltner, Nadja; Liu, Becky; Radu, Constantin; Bhinder, Bhavneet; Kim, Yong Jun; Choi, In Young; Mukherjee-Clavin, Bipasha; Djaballah, Hakim; Studer, Lorenz | Nature biotechnology | 23159879 | 2012 Dec |
| Multicomponent synthesis of diverse 1,4-benzodiazepine scaffolds. | Huang, Yijun; Khoury, Kareem; Chanas, Tyler; Domling, Alexander | Organic letters | 23157402 | 2012 Dec 7 |
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| Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. | Montaser, Rana; Paul, Valerie J; Luesch, Hendrik | Chembiochem : a European journal of chemical biology | 23143757 | 2012 Dec 21 |
| Discovery and SAR of a novel series of non-MPEP site mGluýýý PAMs based on an aryl glycine sulfonamide scaffold. | Rodriguez, Alice L; Zhou, Ya; Williams, Richard; David Weaver, C; Vinson, Paige N; Dawson, Eric S; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolome, Jose M; Macdonald, Gregor J; Scott Daniels, J; Niswender, Colleen M; Jones, Carrie K; Jeffrey | Bioorganic & medicinal chemistry letters | 23142615 | 2012 Dec 15 |
| Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. | Rook, Jerri M; Noetzel, Meredith J; Pouliot, Wendy A; Bridges, Thomas M; Vinson, Paige N; Cho, Hyekyung P; Zhou, Ya; Gogliotti, Rocco D; Manka, Jason T; Gregory, Karen J; Stauffer, Shaun R; Dudek, F Edward; Xiang, Zixiu; Niswender, Colleen M; Daniels, J S | Biological psychiatry | 23140665 | 2013 Mar 15 |
| Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles. | Avila, Belem; El-Dakdouki, Mohammad H; Nazer, Musa Z; Harrison, Jason G; Tantillo, Dean J; Haddadin, Makhluf J; Kurth, Mark J | Tetrahedron letters | 23139435 | 2012 Nov 28 |
| A high-throughput screening assay using Krabbe disease patient cells. | Ribbens, Jameson; Whiteley, Grace; Furuya, Hirokazu; Southall, Noel; Hu, Xin; Marugan, Juan; Ferrer, Marc; Maegawa, Gustavo H B | Analytical biochemistry | 23138179 | 2013 Mar 1 |
| A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. | Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ. | Antimicrob Agents Chemother | 23129054 | 2013 Jan |
| Antimicrobial photodynamic inactivation inhibits Candida albicans virulence factors and reduces in vivo pathogenicity. | Kato, Ilka Tiemy; Prates, Renato Araujo; Sabino, Caetano Padial; Fuchs, Beth Burgwyn; Tegos, George P; Mylonakis, Eleftherios; Hamblin, Michael R; Ribeiro, Martha Simoes | Antimicrobial agents and chemotherapy | 23129051 | 2013 Jan |
| Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011). | Deng, Xianming; Choi, Hwan Geun; Buhrlage, Sara J; Gray, Nathanael S | Expert opinion on therapeutic patents | 23126385 | 2012 Dec |
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| Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection. | Dorjsuren, Dorjbal; Kim, Daemyung; Vyjayanti, Vaddadi N; Maloney, David J; Jadhav, Ajit; Wilson 3rd, David M; Simeonov, Anton | PloS one | 23110144 | 2012 |
| In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts. | Guo, Jianxia; Clausen, Dana M; Beumer, Jan H; Parise, Robert A; Egorin, Merrill J; Bravo-Altamirano, Karla; Wipf, Peter; Sharlow, Elizabeth R; Wang, Qiming Jane; Eiseman, Julie L | Cancer chemotherapy and pharmacology | 23108699 | 2013 Feb |
| Biomimetic synthesis and biological evaluation of Aplidiopsamine A. | Panarese, Joseph D; Lindsley, Craig W | Organic letters | 23106227 | 2012 Nov 16 |
| DAGLýý inhibition perturbs a lipid network involved in macrophage inflammatory responses. | Hsu, Ku-Lung; Tsuboi, Katsunori; Adibekian, Alexander; Pugh, Holly; Masuda, Kim; Cravatt, Benjamin F | Nature chemical biology | 23103940 | 2012 Dec |
| In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear Receptor NR2E3. | Qin, Qiong; Knapinska, Anna; Dobri, Nicoleta; Madoux, Franck; Chase, Peter; Hodder, Peter; Petrukhin, Konstantin | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics | 23098562 | 2013 Apr |
| Compact quantum dots for single-molecule imaging. | Smith, Andrew M; Nie, Shuming | Journal of visualized experiments : JoVE | 23093375 | 2012 |
| The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles. | Haddadin, Makhluf J; Conrad, Wayne E; Kurth, Mark J | Mini reviews in medicinal chemistry | 23092440 | 2012 Oct |
| Discovery of small molecule fusion inhibitors targeting HIV-1 gp41. | Zhou, Guangyan; Chu, Shidong | Current pharmaceutical design | 23092284 | 2013 |
| Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches. | Lynch, Caitlin; Pan, Yongmei; Li, Linhao; Ferguson, Stephen S; Xia, Menghang; Swaan, Peter W; Wang, Hongbing | Pharmaceutical research | 23090669 | 2013 Feb |
| Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy. | Williamson, Elizabeth A; Damiani, Leah; Leitao, Andrei; Hu, Chelin; Hathaway, Helen; Oprea, Tudor; Sklar, Larry; Shaheen, Montaser; Bauman, Julie; Wang, Wei; Nickoloff, Jac A; Lee, Suk-Hee; Hromas, Robert | Cancer research | 23090115 | 2012 Dec 1 |
| Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. | Kim, Yong Wook; Niphakis, Micah J; Georg, Gunda I | The Journal of organic chemistry | 23088256 | 2012 Nov 2 |
| Phylogenetic approaches to natural product structure prediction. | Ziemert, Nadine; Jensen, Paul R | Methods in enzymology | 23084938 | 2012 |
| Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. | Seyedsayamdost, Mohammad R; Traxler, Matthew F; Clardy, Jon; Kolter, Roberto | Methods in enzymology | 23084935 | 2012 |
| Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design. | Custodi, Chiara; Nuti, Roberto; Oprea, Tudor I; Macchiarulo, Antonio | Journal of molecular graphics & modelling | 23079642 | 2012 Sep |
| Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). | Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Saldanha, S Adrian; Chase, Peter; Wang, Zhiwei; Civelli, Olivier; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward | Bioorganic & medicinal chemistry letters | 23079522 | 2012 Dec 1 |
| Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells. | Le Marchand, Sylvain J; Piston, David W | PloS one | 23077547 | 2012 |
| A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase ýý. | Yamanaka, Kinrin; Dorjsuren, Dorjbal; Eoff, Robert L; Egli, Martin; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Lloyd, R Stephen | PloS one | 23056190 | 2012 |
| Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. | Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS. | Environ Health Perspect | 23052129 | 2013 Jan |
| Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. | Du, Lin; King, Jarrod B; Morrow, Brian H; Shen, Jana K; Miller, Andrew N; Cichewicz, Robert H | Journal of natural products | 23046341 | 2012 Oct 26 |
| Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. | Zheng, Weihong; Ibanez, Glorymar; Wu, Hong; Blum, Gil; Zeng, Hong; Dong, Aiping; Li, Fengling; Hajian, Taraneh; Allali-Hassani, Abdellah; Amaya, Maria F; Siarheyeva, Alena; Yu, Wenyu; Brown, Peter J; Schapira, Matthieu; Vedadi, Masoud; Min, Jinrong; Luo, | Journal of the American Chemical Society | 23043551 | 2012 Oct 31 |
| (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. | Moore, Blake P; Chung, Dong Hoon; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Noah, James W; Sosa, Melinda I; Ananthan, Subramaniam; Tower, Nichole A; White, E Lucile; Jia, Fuli; Prisinzano, Thomas E; Aube, Jeffrey; Jonsson, C | Journal of medicinal chemistry | 23043370 | 2012 Oct 25 |
| A torquoselective 6ýý electrocyclization approach to reserpine alkaloids. | Barcan, Gregg A; Patel, Ashay; Houk, K N; Kwon, Ohyun | Organic letters | 23039026 | 2012 Nov 2 |
| Assay Development Guidelines for Image-Based High Content Screening, High Content Analysis and High Content Imaging. | Buchser W, Collins M, Garyantes T, Guha R, Haney S, Lemmon V, Li Z, Trask OJ. | Assay Guidance Manual | 23035272 | 2012 Oct 01 |
| ýý-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. | Xu, Miao; Liu, Ke; Swaroop, Manju; Porter, Forbes D; Sidhu, Rohini; Firnkes, Sally; Finkes, Sally; Ory, Daniel S; Marugan, Juan J; Xiao, Jingbo; Southall, Noel; Pavan, William J; Davidson, Cristin; Walkley, Steven U; Remaley, Alan T; Baxa, Ulrich; Sun, Wei; McKew, John C; Austin, Christopher P; Zheng, Wei | The Journal of biological chemistry | 23035117 | 2012 Nov 16 |
| Identification and characterization of a compound that protects cardiac tissue from human Ether-a-go-go-related gene (hERG)-related drug-induced arrhythmias. | Potet, Franck; Lorinc, Amanda N; Chaigne, Sebastien; Hopkins, Corey R; Venkataraman, Raghav; Stepanovic, Svetlana Z; Lewis, L Michelle; Days, Emily; Sidorov, Veniamin Y; Engers, Darren W; Zou, Beiyan; Afshartous, David; George Jr, Alfred L; Campbell, Cour | The Journal of biological chemistry | 23033485 | 2012 Nov 16 |
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| High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding. | Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A. | PLoS One | 23029124 | 2012 |
| Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. | Carr, Gavin; Derbyshire, Emily R; Caldera, Eric; Currie, Cameron R; Clardy, Jon | Journal of natural products | 23025282 | 2012 Oct 26 |
| MRI biosensor for protein kinase A encoded by a single synthetic gene. | Airan, Raag D; Bar-Shir, Amnon; Liu, Guanshu; Pelled, Galit; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf A | Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 23023588 | 2012 Dec |
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| A coincidence reporter-gene system for high-throughput screening. | Cheng KC, Inglese J. | Nat Methods | 23018994 | 2012 Oct |
| Briareolate esters from the gorgonian Briareum asbestinum. | Meginley, Rian J; Gupta, Prasoon; Schulz, Thomas C; McLean, Amanda B; Robins, Allan J; West, Lyndon M | Marine drugs | 23015768 | 2012 Aug |
| Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics. | Kong, Koon Yin; Marcus, Adam I; Giannakakou, Paraskevi; Wang, May Dongmei | International journal of computational biology and drug design | 23013655 | 2012 |
| TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. | Nayar, Ribhu; Enos, Megan; Prince, Amanda; Shin, Hyunmu; Hemmers, Saskia; Jiang, Jian-kang; Klein, Ulf; Thomas, Craig J; Berg, Leslie J | Proceedings of the National Academy of Sciences of the United States of America | 23011795 | 2012 Oct 9 |
| Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. | Maloney, Patrick R; Khan, Pasha; Hedrick, Michael; Gosalia, Palak; Milewski, Monika; Li, Linda; Roth, Gregory P; Sergienko, Eduard; Suyama, Eigo; Sugarman, Eliot; Nguyen, Kevin; Mehta, Alka; Vasile, Stefan; Su, Ying; Stonich, Derek; Nguyen, Hung; Zeng, Fu | Bioorganic & medicinal chemistry letters | 23010269 | 2012 Nov 1 |
| Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. | Knapp, John M; Zhu, Jie S; Tantillo, Dean J; Kurth, Mark J | Angewandte Chemie (International ed. in English) | 23001913 | 2012 Oct 15 |
| Rapidly relocating molecules between organelles to manipulate small GTPase activity. | Phua, Siew Cheng; Pohlmeyer, Christopher; Inoue, Takanari | ACS chemical biology | 22999378 | 2012 Dec 21 |
| Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases. | Smanski, Michael J; Peterson, Ryan M; Shen, Ben | Methods in enzymology | 22999174 | 2012 |
| Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. | Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. | J Transl Med | 22999104 | 2012 Sep 21 |
| Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. | Cacho, Ralph A; Jiang, Wei; Chooi, Yit-Heng; Walsh, Christopher T; Tang, Yi | Journal of the American Chemical Society | 22998630 | 2012 Oct 10 |
| Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. | Huang, Fen; Zhang, Hongkang; Wu, Meng; Yang, Huanghe; Kudo, Makoto; Peters, Christian J; Woodruff, Prescott G; Solberg, Owen D; Donne, Matthew L; Huang, Xiaozhu; Sheppard, Dean; Fahy, John V; Wolters, Paul J; Hogan, Brigid L M; Finkbeiner, Walter E; Li, M | Proceedings of the National Academy of Sciences of the United States of America | 22988107 | 2012 Oct 2 |
| Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds. | Tomasini-Johansson, Bianca R; Johnson, Ian A; Hoffmann, F Michael; Mosher, Deane F | Matrix biology : journal of the International Society for Matrix Biology | 22986508 | 2012 Jul |
| Structure and biosynthesis of the antibiotic bottromycin D. | Hou, Yanpeng; Tianero, Ma Diarey B; Kwan, Jason C; Wyche, Thomas P; Michel, Cole R; Ellis, Gregory A; Vazquez-Rivera, Emmanuel; Braun, Doug R; Rose, Warren E; Schmidt, Eric W; Bugni, Tim S | Organic letters | 22984777 | 2012 Oct 5 |
| Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. | Sirenko, Oksana; Crittenden, Carole; Callamaras, Nick; Hesley, Jayne; Chen, Yen-Wen; Funes, Carlos; Rusyn, Ivan; Anson, Blake; Cromwell, Evan F | Journal of biomolecular screening | 22972846 | 2013 Jan |
| Novel selective allosteric and bitopic ligands for the S1P(3) receptor. | Jo, Euijung; Bhhatarai, Barun; Repetto, Emanuela; Guerrero, Miguel; Riley, Sean; Brown, Steven J; Kohno, Yasushi; Roberts, Edward; Schurer, Stephan C; Rosen, Hugh | ACS chemical biology | 22971058 | 2012 Dec 21 |
| Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. | Khoury, Kareem; Sinha, Mantosh K; Nagashima, Tadamichi; Herdtweck, Eberhardt; Domling, Alexander | Angewandte Chemie (International ed. in English) | 22968839 | 2012 Oct 8 |
| A dual-column solid phase extraction strategy for online collection and preparation of continuously flowing effluent streams for mass spectrometry. | Enders, Jeffrey R; Marasco, Christina C; Wikswo, John P; McLean, John A | Analytical chemistry | 22967262 | 2012 Oct 16 |
| New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. | Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Kron, Michael; Shen, Ben | Organic letters | 22967068 | 2012 Sep 21 |
| 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. | Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, A | Nature structural & molecular biology | 22961382 | 2012 Oct |
| 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. | Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, Albert H C; Blencowe, Benjamin J; Wang, Sun Chong; Kapranov, Philipp; Kustra, Rafal; Labrie, Viviane; Klimasauskas, Saulius; Petronis, Arturas | Nature structural & molecular biology | 22961382 | 2012 Oct |
| Small molecule inhibitors of RORýýt: targeting Th17 cells and other applications. | Huh, Jun R; Littman, Dan R | European journal of immunology | 22949321 | 2012 Sep |
| Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. | Pouliot, Lynn M; Chen, Yu-Chi; Bai, Jennifer; Guha, Rajarshi; Martin, Scott E; Gottesman, Michael M; Hall, Matthew D | Cancer research | 22942255 | 2012 Nov 15 |
| Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. | Ndjomou, Jean; Kolli, Rajesh; Mukherjee, Sourav; Shadrick, William R; Hanson, Alicia M; Sweeney, Noreena L; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David N | Antiviral research | 22940425 | 2012 Nov |
| Navigating the fungal polyketide chemical space: from genes to molecules. | Chooi, Yit-Heng; Tang, Yi | The Journal of organic chemistry | 22938194 | 2012 Nov 16 |
| Interspecies modulation of bacterial development through iron competition and siderophore piracy. | Traxler, Matthew F; Seyedsayamdost, Mohammad R; Clardy, Jon; Kolter, Roberto | Molecular microbiology | 22931126 | 2012 Nov |
| Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination? | Dai, Tianhong; Murray, Clinton K; Vrahas, Mark S; Baer, David G; Tegos, George P; Hamblin, Michael R | The journal of trauma and acute care surgery | 22929495 | 2012 Sep |
| Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. | Tebbets, Brad; Yu, Zhiguo; Stewart, Douglas; Zhao, Li-Xing; Jiang, Yi; Xu, Li-Hua; Andes, David; Shen, Ben; Klein, Bruce | Medical mycology : official publication of the International Society for Human and Animal Mycology | 22928922 | 2012 Aug 28 |
| One-pot phosphine-catalyzed syntheses of quinolines. | Khong, San; Kwon, Ohyun | The Journal of organic chemistry | 22928667 | 2012 Sep 21 |
| A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells. | Mathews, Lesley A; Keller, Jonathan M; Goodwin, Bonnie L; Guha, Rajarshi; Shinn, Paul; Mull, Rebecca; Thomas, Craig J; de Kluyver, Rachel L; Sayers, Thomas J; Ferrer, Marc | Journal of biomolecular screening | 22927676 | 2012 Oct |
| High throughput measurement of Caýýýýý dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry. | Cerignoli, Fabio; Charlot, David; Whittaker, Ross; Ingermanson, Randy; Gehalot, Piyush; Savchenko, Alex; Gallacher, David J; Towart, Rob; Price, Jeffrey H; McDonough, Patrick M; Mercola, Mark | Journal of pharmacological and toxicological methods | 22926323 | 2012 Nov-Dec |
| Stereoselective synthesis of acortatarins A and B. | Wurst, Jacqueline M; Verano, Alyssa L; Tan, Derek S | Organic letters | 22924668 | 2012 Sep 7 |
| Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. | Boudreau, Paul D; Byrum, Tara; Liu, Wei-Ting; Dorrestein, Pieter C; Gerwick, William H | Journal of natural products | 22924493 | 2012 Sep 28 |
| Synthesis of Tetrazolo-Fused Benzodiazepines and Benzodiazepinones by a Two-Step Protocol Using an Ugi-Azide Reaction for Initial Diversity Generation. | Gunawan, Steven; Ayaz, Muhammad; De Moliner, Fabio; Frett, Brendan; Kaiser, Christine; Patrick, Nina; Xu, Zhigang; Hulme, Christopher | Tetrahedron | 22923851 | 2012 Jul 8 |
| A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. | Strouse, J Jacob; Ivnitski-Steele, Irena; Khawaja, Hadya M; Perez, Dominique; Ricci, Jerec; Yao, Tuanli; Weiner, Warren S; Schroeder, Chad E; Simpson, Denise S; Maki, Brooks E; Li, Kelin; Golden, Jennifer E; Foutz, Terry D; Waller, Anna; Evangelisti, Anne | Journal of biomolecular screening | 22923785 | 2013 Jan |
| Activation of the ATM-Snail pathway promotes breast cancer metastasis. | Sun, Mianen; Guo, Xiaojing; Qian, Xiaolong; Wang, Haibo; Yang, Chunying; Brinkman, Kathryn L; Serrano-Gonzalez, Monica; Jope, Richard S; Zhou, Binhua; Engler, David A; Zhan, Ming; Wong, Stephen T C; Fu, Li; Xu, Bo | Journal of molecular cell biology | 22923499 | 2012 Oct |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. | Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin | Nature chemical biology | 22922757 | 2012 Oct |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. | Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin D; Malstrom, Scott; Khan, Tahsin M; Kung, Charles; Skoumbourdis, Amanda P; Veith, Henrike; Southall, Noel; Walsh, Martin J; Brimacombe, Kyle R; Leister, William; Lunt, Sophia Y; Johnson, Zachary R; Yen, Katharine E; Kunii, Kaiko; Davidson, Shawn M; Christofk, Heather R; Austin, Christopher P; Inglese, James; Harris, Marian H; Asara, John M; Stephanopoulos, Gregory; Salituro, Francesco G; Jin, Shengfang; Dang, Lenny; Auld, Douglas S; Park, Hee-Won; Cantley, Lewis C; Thomas, Craig J; Vander Heiden, Matthew G | Nature chemical biology | 22922757 | 2012 Oct |
| Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. | Thorne, Natasha; Shen, Min; Lea, Wendy A; Simeonov, Anton; Lovell, Scott; Auld, Douglas S; Inglese, James | Chemistry & biology | 22921073 | 2012 Aug 24 |
| Total synthesis of (ýý)-hirsutine: application of phosphine-catalyzed imine-allene [4 + 2] annulation. | Villa, Reymundo A; Xu, Qihai; Kwon, Ohyun | Organic letters | 22920858 | 2012 Sep 7 |
| Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysis. | O'Reilly, Matthew C; Lindsley, Craig W | Tetrahedron letters | 22919116 | 2012 Mar 28 |
| Cyclosporine A and bromocriptine attenuate cell death mediated by intracellular calcium mobilization. | Kim, In Ki; Park, So Jung; Park, Jhang Ho; Lee, Seung-Ho; Hong, Sung Eun; Reed, John C | BMB reports | 22917034 | 2012 Aug |
| Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFýý interaction. | Cunningham, Lea; Finckbeiner, Steven; Hyde, R Katherine; Southall, Noel; Marugan, Juan; Yedavalli, Venkat R K; Dehdashti, Seameen Jean; Reinhold, William C; Alemu, Lemlem; Zhao, Ling; Yeh, Jing-Ruey Joanna; Sood, Raman; Pommier, Yves; Austin, Christopher P; Jeang, Kuan-Teh; Zheng, Wei; Liu, Paul | Proceedings of the National Academy of Sciences of the United States of America | 22912405 | 2012 Sep 4 |
| Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. | Mattmann, Margrith E; Yu, Haibo; Lin, Zhihong; Xu, Kaiping; Huang, Xiaofang; Long, Shunyou; Wu, Meng; McManus, Owen B; Engers, Darren W; Le, Uyen M; Li, Min; Lindsley, Craig W; Hopkins, Corey R | Bioorganic & medicinal chemistry letters | 22910039 | 2012 Sep 15 |
| A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. | Morgan, Hugh P; Walsh, Martin J; Blackburn, Elizabeth A; Wear, Martin A; Boxer, Matthew B; Shen, Min; Veith, Henrike; McNae, Iain W; Nowicki, Matthew W; Michels, Paul A M; Auld, Douglas S; Fothergill-Gilmore, Linda A; Walkinshaw, Malcolm D | The Biochemical journal | 22906073 | 2012 Nov 15 |
| Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. | Gao, Xue; Haynes, Stuart W; Ames, Brian D; Wang, Peng; Vien, Linda P; Walsh, Christopher T; Tang, Yi | Nature chemical biology | 22902615 | 2012 Oct |
| Bacterial pathogens commandeer rab GTPases to establish intracellular niches. | Stein, Mary-Pat; Muller, Matthias P; Wandinger-Ness, Angela | Traffic (Copenhagen, Denmark) | 22901006 | 2012 Dec |
| A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. | Seguin, Sandlin P; Ireland, Alex W; Gupta, Tushar; Wright, Christine M; Miyata, Yoshinari; Wipf, Peter; Pipas, James M; Gestwicki, Jason E; Brodsky, Jeffrey L | Antiviral research | 22898086 | 2012 Oct |
| A suite of modular fluorescence assays interrogate the human immunodeficiency virus glycoprotein-41 coiled coil and assist in determining binding mechanism of low molecular weight fusion inhibitors. | Gochin, Miriam | Assay and drug development technologies | 22897493 | 2012 Oct |
| Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. | Avila, Belem; Roth, Aaron; Streets, Heather; Dwyer, Donard S; Kurth, Mark J | Bioorganic & medicinal chemistry letters | 22892117 | 2012 Sep 15 |
| Labeling of neuronal receptors and transporters with quantum dots. | Chang, Jerry C; Kovtun, Oleg; Blakely, Randy D; Rosenthal, Sandra J | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | 22887823 | 2012 Nov-Dec |
| Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification. | Kiffer-Moreira, Tina; Yadav, Manisha C; Zhu, Dongxing; Narisawa, Sonoko; Sheen, Campbell; Stec, Boguslaw; Cosford, Nicholas D; Dahl, Russell; Farquharson, Colin; Hoylaerts, Marc F; Macrae, Vicky E; Millan, Jose Luis | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 22887744 | 2013 Jan |
| Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. | Thal, David M; Homan, Kristoff T; Chen, Jun; Wu, Emily K; Hinkle, Patricia M; Huang, Z Maggie; Chuprun, J Kurt; Song, Jianliang; Gao, Erhe; Cheung, Joseph Y; Sklar, Larry A; Koch, Walter J; Tesmer, John J G | ACS chemical biology | 22882301 | 2012 Nov 16 |
| Exploring uncharted territories: predicting activity cliffs in structure-activity landscapes. | Guha, Rajarshi | Journal of chemical information and modeling | 22873578 | 2012 Aug 27 |
| Biochemical analysis of protein SUMOylation. | Alontaga, Aileen Y; Bobkova, Ekaterina; Chen, Yuan | Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] | 22870855 | 2012 Jul |
| Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. | Wu, Victoria M; Chen, Steven C; Arkin, Michelle R; Reiter, Jeremy F | Proceedings of the National Academy of Sciences of the United States of America | 22864913 | 2012 Aug 21 |
| Challenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics. | Xu X, Vugmeyster Y. | AAPS J | 22864668 | 2012 Dec |
| Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. | Gregory, Karen J; Noetzel, Meredith J; Rook, Jerri M; Vinson, Paige N; Stauffer, Shaun R; Rodriguez, Alice L; Emmitte, Kyle A; Zhou, Ya; Chun, Aspen C; Felts, Andrew S; Chauder, Brian A; Lindsley, Craig W; Niswender, Colleen M; Conn, P Jeffrey | Molecular pharmacology | 22863693 | 2012 Nov |
| GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. | Reith, Alastair D; Bamborough, Paul; Jandu, Karamjit; Andreotti, Daniele; Mensah, Lucy; Dossang, Pamela; Choi, Hwan Geun; Deng, Xianming; Zhang, Jinwei; Alessi, Dario R; Gray, Nathanael S | Bioorganic & medicinal chemistry letters | 22863203 | 2012 Sep 1 |
| Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. | Wen, Qiang; Goldenson, Benjamin; Silver, Serena J; Schenone, Monica; Dancik, Vlado; Huang, Zan; Wang, Ling-Zhi; Lewis, Timothy A; An, W Frank; Li, Xiaoyu; Bray, Mark-Anthony; Thiollier, Clarisse; Diebold, Lauren; Gilles, Laure; Vokes, Martha S; Moore, Chr | Cell | 22863010 | 2012 Aug 3 |
| Assembly of four diverse heterocyclic libraries enabled by Prins cyclization, Au-catalyzed enyne cycloisomerization, and automated amide synthesis. | Cui, Jiayue; Chai, David I; Miller, Christopher; Hao, Jason; Thomas, Christopher; Wang, JingQi; Scheidt, Karl A; Kozmin, Sergey A | The Journal of organic chemistry | 22860634 | 2012 Sep 7 |
| Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions. | Sahn, James J; Martin, Stephen F | ACS combinatorial science | 22857149 | 2012 Aug 20 |
| Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy. | Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R | ACS combinatorial science | 22853708 | 2012 Aug 13 |
| Estimating the Lipophilicity of Natural Products using a Polymeric Reversed Phase HPLC Method. | Zheng, Bo; West, Lyndon M | Journal of liquid chromatography & related technologies | 22851883 | 2009 |
| Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage. | Yang, Chunying; Lee, Michael; Hao, Jianwei; Cui, Xiaoli; Guo, Xiaojing; Smal, Caroline; Bontemps, Francoise; Ma, Shumei; Liu, Xiaodong; Engler, David; Parker, William B; Xu, Bo | Nucleic acids research | 22850745 | 2012 Oct |
| Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target. | Treger, R S; Cook, A G; Rai, G; Maloney, D J; Simeonov, A; Jadhav, A; Thomas, C J; Williams, D L; Cappello, M; Vermeire, J J | International journal for parasitology, drugs and drug resistance | 22844653 | 2012 Dec 1 |
| Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring. | Gerea, Alexandra L; Branscum, Katie M; King, Jarrod B; You, Jianlan; Powell, Douglas R; Miller, Andrew N; Spear, John R; Cichewicz, Robert H | Tetrahedron letters | 22844162 | 2012 Aug 8 |
| Click-based synthesis of triazolobithiazole ýýF508-CFTR correctors for cystic fibrosis. | Donald, Michael B; Rodriguez, Kevin X; Shay, Hannah; Phuan, Puay-Wah; Verkman, A S; Kurth, Mark J | Bioorganic & medicinal chemistry | 22841006 | 2012 Sep 1 |
| Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. | Bannwarth, Ludovic; Goldberg, Allison B; Chen, Catherine; Turk, Benjamin E | Chemistry & biology | 22840775 | 2012 Jul 27 |
| Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ýýýýP and ýýýýC NMR spectroscopy. | Jeffries, Rex E; Gamcsik, Michael P; Keshari, Kayvan R; Pediaditakis, Peter; Tikunov, Andrey P; Young, Gregory B; Lee, Haakil; Watkins, Paul B; Macdonald, Jeffrey M | Tissue engineering. Part C, Methods | 22835003 | 2013 Feb |
| Discovery of a novel noniminosugar acid ýý glucosidase chaperone series. | Xiao, Jingbo; Westbroek, Wendy; Motabar, Omid; Lea, Wendy A; Hu, Xin; Velayati, Arash; Zheng, Wei; Southall, Noel; Gustafson, Ann Marie; Goldin, Ehud; Sidransky, Ellen; Liu, Ke; Simeonov, Anton; Tamargo, Rafael J; Ribes, Antonia; Matalonga, Leslie; Ferrer, Marc; Marugan, Juan J | Journal of medicinal chemistry | 22834902 | 2012 Sep 13 |
| Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic Dynein-mediated transport of glucocorticoid receptor to the nucleus. | Johnston, Paul A; Shinde, Sunita N; Hua, Yun; Shun, Tong Ying; Lazo, John S; Day, Billy W | Assay and drug development technologies | 22830992 | 2012 Oct |
| Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. | Seyedsayamdost, Mohammad R; Cleto, Sara; Carr, Gavin; Vlamakis, Hera; Joao Vieira, Maria; Kolter, Roberto; Clardy, Jon | Journal of the American Chemical Society | 22830960 | 2012 Aug 22 |
| Drug repurposing: far beyond new targets for old drugs. | Oprea, T I; Mestres, J | The AAPS journal | 22826034 | 2012 Dec |
| A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles. | Conrad, Wayne E; Rodriguez, Kevin X; Nguyen, Huy H; Fettinger, James C; Haddadin, Makhluf J; Kurth, Mark J | Organic letters | 22823414 | 2012 Aug 3 |
| Development of drugs for Epstein-Barr virus using high-throughput in silico virtual screening. | Li, Ning; Thompson, Scott; Jiang, Hualiang; Lieberman, Paul M; Luo, Cheng | Expert opinion on drug discovery | 22822721 | 2010 Dec |
| Plasma and tissue concentrations of ýý-tocopherol and ýý-tocopherol following high dose dietary supplementation in mice. | Baxter, Laura L; Marugan, Juan J; Xiao, Jingbo; Incao, Art; McKew, John C; Zheng, Wei; Pavan, William J | Nutrients | 22822447 | 2012 Jun |
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| Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. | Krueger, Aaron B; Dehdashti, Seameen J; Southall, Noel; Marugan, Juan J; Ferrer, Marc; Li, Xueni; Ford, Heide L; Zheng, Wei; Zhao, Rui | Journal of biomolecular screening | 22820394 | 2013 Jan |
| Development of 'DFG-out' inhibitors of gatekeeper mutant kinases. | Choi, Hwan Geun; Zhang, Jianming; Weisberg, Ellen; Griffin, James D; Sim, Taebo; Gray, Nathanael S | Bioorganic & medicinal chemistry letters | 22819762 | 2012 Aug 15 |
| Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces paras | Preuss, Janina; Maloney, Patrick; Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Gosalia, Palak; Milewski, Monika; Li, Yujie Linda; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Vasile, Stefan; Sergienko, Eduard; Mangravi | Journal of medicinal chemistry | 22813531 | 2012 Aug 23 |
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| A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. | Polireddy, Kishore; Khan, Mohiuddin Md Taimur; Chavan, Hemantkumar; Young, Susan; Ma, Xiaochao; Waller, Anna; Garcia, Matthew; Perez, Dominique; Chavez, Stephanie; Strouse, Jacob J; Haynes, Mark K; Bologa, Cristian G; Oprea, Tudor I; Tegos, George P; Skla | PloS one | 22808084 | 2012 |
| Absorption, distribution, metabolism, and excretion (ADME) studies of biotherapeutics for autoimmune and inflammatory conditions. | Vugmeyster, Yulia; Harrold, John; Xu, Xin | The AAPS journal | 22798020 | 2012 Dec |
| Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, | Cheung, Yiu-Yin; Yu, Haibo; Xu, Kaiping; Zou, Beiyan; Wu, Meng; McManus, Owen B; Li, Min; Lindsley, Craig W; Hopkins, Corey R | Journal of medicinal chemistry | 22793372 | 2012 Aug 9 |
| Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2. | Wang, Wei; Cao, Haiping; Wolf, Siglinde; Camacho-Horvitz, Miguel S; Holak, Tad A; Domling, Alexander | Bioorganic & medicinal chemistry | 22789708 | 2013 Jul 15 |
| A multiplexed siRNA screening strategy to identify genes in the PARP pathway. | Stec, Erica; Locco, Louis; Szymanski, Stacey; Bartz, Steven R; Toniatti, Carlo; Needham, Rachel H V; Palmieri, Anthony; Carleton, Michael; Cleary, Michele A; Jackson, Aimee L; Linsley, Peter S; Strulovici, Berta; Ferrer, Marc; Santini, Francesca | Journal of biomolecular screening | 22786893 | 2012 Dec |
| Unusual Friedlander Reactions: A Route to Novel Quinoxaline-Based Heterocycles. | Shoker, Tharallah A; Ghattass, Khaled I; Fettinger, James C; Kurth, Mark J; Haddadin, Makhluf J | Organic letters | 22783916 | 2012 Jul 11 |
| O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase. | Talukdar, Arindam; Zhao, Yujie; Lv, Wei; Bacher, Adelbert; Illarionov, Boris; Fischer, Markus; Cushman, Mark | The Journal of organic chemistry | 22780198 | 2012 Jul 20 |
| Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles. | Pathak, Tejas P; Osiak, Jaroslaw G; Vaden, Rachel M; Welm, Bryan E; Sigman, Matthew S | Tetrahedron | 22778488 | 2012 Jul 1 |
| Highly efficient click labeling using 2-[ýýýýýF]fluoroethyl azide and synthesis of an ýýýýýFN-hydroxysuccinimide ester as conjugation agent. | Zhou, Dong; Chu, Wenhua; Dence, Carmen S; Mach, Robert H; Welch, Michael J | Nuclear medicine and biology | 22770647 | 2012 Nov |
| A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel. | Yang, Huaiyu; Gao, Zhaobing; Li, Ping; Yu, Kunqian; Yu, Ye; Xu, Tian-Le; Li, Min; Jiang, Hualiang | Biophysical journal | 22768937 | 2012 Apr 18 |
| A FRET-based high throughput screening assay to identify inhibitors of anthrax protective antigen binding to capillary morphogenesis gene 2 protein. | Rogers, Michael S; Cryan, Lorna M; Habeshian, Kaiane A; Bazinet, Lauren; Caldwell, Thomas P; Ackroyd, P Christine; Christensen, Kenneth A | PloS one | 22768167 | 2012 |
| A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. | Somvanshi, Vishal S; Sloup, Rudolph E; Crawford, Jason M; Martin, Alexander R; Heidt, Anthony J; Kim, Kwi-suk; Clardy, Jon; Ciche, Todd A | Science (New York, N.Y.) | 22767929 | 2012 Jul 6 |
| Discovery of regulators of receptor internalization with high-throughput flow cytometry. | Wu, Yang; Tapia, Phillip H; Fisher, Gregory W; Simons, Peter C; Strouse, J Jacob; Foutz, Terry; Waggoner, Alan S; Jarvik, Jonathan; Sklar, Larry A | Molecular pharmacology | 22767611 | 2012 Oct |
| Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. | Grimm, Christian; Jors, Simone; Guo, Zhaohua; Obukhov, Alexander G; Heller, Stefan | The Journal of biological chemistry | 22753890 | 2012 Jun 29 |
| Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes. | Choi, Eun Ju; Beatty, Deanna S; Paul, Lauren A; Fenical, William; Jensen, Paul R | International journal of systematic and evolutionary microbiology | 22753528 | 2013 Apr |
| Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles. | Xu, Zhigang; De Moliner, Fabio; Cappelli, Alexandra P; Hulme, Christopher | Angewandte Chemie (International ed. in English) | 22753341 | 2012 Aug 6 |
| Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012. | Melancon, Bruce J; Utley, Thomas J; Sevel, Christian; Mattmann, Margrith E; Cheung, Yiu-Yin; Bridges, Thomas M; Morrison, Ryan D; Sheffler, Douglas J; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R | Bioorganic & medicinal chemistry letters | 22749871 | 2012 Aug 1 |
| One-Pot, Two-Step Cascade Synthesis of Quinazolinotriazolobenzodiazepines. | Guggenheim, Kathryn G; Toru, Hannah; Kurth, Mark J | Organic letters | 22746550 | 2012 Jun 29 |
| General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity. | Xu, Zhigang; Ayaz, Muhammad; Cappelli, Alexandra A; Hulme, Christopher | ACS combinatorial science | 22746181 | 2012 Aug 13 |
| Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. | Chang, Jerry C; Tomlinson, Ian D; Warnement, Michael R; Ustione, Alessandro; Carneiro, Ana M D; Piston, David W; Blakely, Randy D; Rosenthal, Sandra J | The Journal of neuroscience : the official journal of the Society for Neuroscience | 22745492 | 2012 Jun 27 |
| Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel. | Zhang, Hongkang; Zou, Beiyan; Yu, Haibo; Moretti, Alessandra; Wang, Xiaoying; Yan, Wei; Babcock, Joseph J; Bellin, Milena; McManus, Owen B; Tomaselli, Gordon; Nan, Fajun; Laugwitz, Karl-Ludwig; Li, Min | Proceedings of the National Academy of Sciences of the United States of America | 22745159 | 2012 Jul 17 |
| Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays. | Mukherjee, Sourav; Hanson, Alicia M; Shadrick, William R; Ndjomou, Jean; Sweeney, Noreena L; Hernandez, John J; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Heck, Julie A; Arnold, Leggy A; Schoenen, Frank J; Frick, David N | Nucleic acids research | 22740655 | 2012 Sep 1 |
| Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor. | Salovich, James M; Vinson, Paige N; Sheffler, Douglas J; Lamsal, Atin; Utley, Thomas J; Blobaum, Anna L; Bridges, Thomas M; Le, Uyen; Jones, Carrie K; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, Co | Bioorganic & medicinal chemistry letters | 22738637 | 2012 Aug 1 |
| Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. | Frankowski, Kevin J; Hedrick, Michael P; Gosalia, Palak; Li, Kelin; Shi, Shenghua; Whipple, David; Ghosh, Partha; Prisinzano, Thomas E; Schoenen, Frank J; Su, Ying; Vasile, S; Sergienko, Eduard; Gray, Wilson; Hariharan, Santosh; Milan, Loribelle; Heynen-G | ACS chemical neuroscience | 22737280 | 2012 Mar 21 |
| TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. | Yuan, Hsiangkuo; Fales, Andrew M; Vo-Dinh, Tuan | Journal of the American Chemical Society | 22734608 | 2012 Jul 18 |
| Pharmacokinetic, biodistribution, and biophysical profiles of TNF nanobodies conjugated to linear or branched poly(ethylene glycol). | Vugmeyster, Yulia; Entrican, Clifford A; Joyce, Alison P; Lawrence-Henderson, Rosemary F; Leary, Beth A; Mahoney, Christopher S; Patel, Himakshi K; Raso, Stephen W; Olland, Stephane H; Hegen, Martin; Xu, Xin | Bioconjugate chemistry | 22731748 | 2012 Jul 18 |
| Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. | Delpire, Eric; Baranczak, Aleksandra; Waterson, Alex G; Kim, Kwangho; Kett, Nathan; Morrison, Ryan D; Daniels, J Scott; Weaver, C David; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 22727639 | 2012 Jul 15 |
| An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRýý and kit. | Deng, Xianming; Zhou, Wenjun; Weisberg, Ellen; Wang, Jinhua; Zhang, Jianming; Sasaki, Takaaki; Nelson, Erik; Griffin, James D; Janne, Pasi A; Gray, Nathanael S | Bioorganic & medicinal chemistry letters | 22727638 | 2012 Jul 15 |
| Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. | Smith, Susan M E; Min, Jaeki; Ganesh, Thota; Diebold, Becky; Kawahara, Tsukasa; Zhu, Yerun; McCoy, James; Sun, Aiming; Snyder, James P; Fu, Haian; Du, Yuhong; Lewis, Iestyn; Lambeth, J David | Chemistry & biology | 22726689 | 2012 Jun 22 |
| Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules. | Sun, Hongmao; Shahane, Sampada; Xia, Menghang; Austin, Christopher P; Huang, Ruili | Journal of chemical information and modeling | 22725677 | 2012 Jul 5 |
| Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. | Digby, Gregory J; Noetzel, Meredith J; Bubser, Michael; Utley, Thomas J; Walker, Adam G; Byun, Nellie E; Lebois, Evan P; Xiang, Zixiu; Sheffler, Douglas J; Cho, Hyekyung P; Davis, Albert A; Nemirovsky, Natali E; Mennenga, Sarah E; Camp, Bryan W; Bimonte-N | The Journal of neuroscience : the official journal of the Society for Neuroscience | 22723693 | 2012 Jun 20 |
| Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol. | Fan, Yi Chiao; Kwon, Ohyun | Organic letters | 22721256 | 2012 Jul 6 |
| A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. | Chen, Yun; Cao, Shugeng; Chai, Yunrong; Clardy, Jon; Kolter, Roberto; Guo, Jian-hua; Losick, Richard | Molecular microbiology | 22716461 | 2012 Aug |
| Facile Syntheses of Substituted, Conformationally-Constrained Benzoxazocines and Benzazocines via Sequential Multicomponent Assembly and Cyclization. | Sahn, James J; Martin, Stephen F | Tetrahedron letters | 22711939 | 2011 Dec 21 |
| Small molecule perimeter defense in entomopathogenic bacteria. | Crawford, Jason M; Portmann, Cyril; Zhang, Xu; Roeffaers, Maarten B J; Clardy, Jon | Proceedings of the National Academy of Sciences of the United States of America | 22711807 | 2012 Jul 3 |
| A high-throughput sphingomyelinase assay using natural substrate. | Xu, Miao; Liu, Ke; Southall, Noel; Marugan, Juan J; Remaley, Alan T; Zheng, Wei | Analytical and bioanalytical chemistry | 22710568 | 2012 Aug |
| Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones. | Gunawan, Steven; Nichol, Gary; Hulme, Christopher | Tetrahedron letters | 22707799 | 2012 Mar 28 |
| A fluorescent screening assay for identifying modulators of GIRK channels. | Vazquez, Maribel; Dunn, Charity A; Walsh, Kenneth B | Journal of visualized experiments : JoVE | 22706581 | 2012 |
| Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. | Yang, Yibin; Shaffer 3rd, Arthur L; Emre, N C Tolga; Ceribelli, Michele; Zhang, Meili; Wright, George; Xiao, Wenming; Powell, John; Platig, John; Kohlhammer, Holger; Young, Ryan M; Zhao, Hong; Yang, Yandan; Xu, Weihong; Buggy, Joseph J; Balasubramanian, Sriram; Mathews, Lesley A; Shinn, Paul; Guha, Rajarshi; Ferrer, Marc; Thomas, Craig; Waldmann, Thomas A; Staudt, Louis M | Cancer cell | 22698399 | 2012 Jun 12 |
| Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. | Adibekian, Alexander; Martin, Brent R; Chang, Jae Won; Hsu, Ku-Lung; Tsuboi, Katsunori; Bachovchin, Daniel A; Speers, Anna E; Brown, Steven J; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter S; Rosen, Hugh; Cravatt, Benjamin F | Journal of the American Chemical Society | 22690931 | 2012 Jun 27 |
| Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110ýý inhibition as a potential therapeutic strategy. | Law, Amanda J; Wang, Yanhong; Sei, Yoshitatsu; O'Donnell, Patricio; Piantadosi, Patrick; Papaleo, Francesco; Straub, Richard E; Huang, Wenwei; Thomas, Craig J; Vakkalanka, Radhakrishna; Besterman, Aaron D; Lipska, Barbara K; Hyde, Thomas M; Harrison, Paul J; Kleinman, Joel E; Weinberger, Daniel R | Proceedings of the National Academy of Sciences of the United States of America | 22689948 | 2012 Jul 24 |
| Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity. | Sekar, Divya; Hahn, Christina; Brune, Bernhard; Roberts, Edward; Weigert, Andreas | European journal of immunology | 22678911 | 2012 Jun |
| Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance. | Choe, Keith P; Leung, Chi K; Miyamoto, Michael M | Drug metabolism reviews | 22656429 | 2012 Aug |
| Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. | Kaila, Neelu; Huang, Adrian; Moretto, Alessandro; Follows, Bruce; Janz, Kristin; Lowe, Michael; Thomason, Jennifer; Mansour, Tarek S; Hubeau, Cedric; Page, Karen; Morgan, Paul; Fish, Susan; Xu, Xin; Williams, Cara; Saiah, Eddine | Journal of medicinal chemistry | 22651823 | 2012 Jun 14 |
| P53 mdm2 inhibitors. | Khoury, Kareem; Domling, Alex | Current pharmaceutical design | 22650254 | 2012 |
| Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. | Patnaik, Samarjit; Zheng, Wei; Choi, Jae H; Motabar, Omid; Southall, Noel; Westbroek, Wendy; Lea, Wendy A; Velayati, Arash; Goldin, Ehud; Sidransky, Ellen; Leister, William; Marugan, Juan J | Journal of medicinal chemistry | 22646221 | 2012 Jun 28 |
| siRNA off-target effects in genome-wide screens identify signaling pathway members. | Buehler, Eugen; Khan, Aly A; Marine, Shane; Rajaram, Misha; Bahl, Amit; Burchard, Julja; Ferrer, Marc | Scientific reports | 22645644 | 2012 |
| Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. | Gonzalez, David J; Xu, Yuquan; Yang, Yu-Liang; Esquenazi, Eduardo; Liu, Wei-Ting; Edlund, Anna; Duong, Tram; Du, Liangcheng; Molnar, Istvan; Gerwick, William H; Jensen, Paul R; Fischbach, Michael; Liaw, Chih-Chuang; Straight, Paul; Nizet, Victor; Dorreste | Journal of proteomics | 22641157 | 2012 Aug 30 |
| Synthesis of peptidomimetics, ýý- and ýý-lactam tetrazoles. | Gunawan, Steven; Keck, Kristen; Laetsch, Alex; Hulme, Christopher | Molecular diversity | 22622388 | 2012 Aug |
| A general, enantioselective synthesis of protected morpholines and piperazines. | O'Reilly, Matthew C; Lindsley, Craig W | Organic letters | 22616979 | 2012 Jun 1 |
| Solution-phase synthesis of a highly substituted furan library. | Cho, Chul-Hee; Shi, Feng; Jung, Dai-Il; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C | ACS combinatorial science | 22612549 | 2012 Jul 9 |
| The spectral networks paradigm in high throughput mass spectrometry. | Guthals, Adrian; Watrous, Jeramie D; Dorrestein, Pieter C; Bandeira, Nuno | Molecular bioSystems | 22610447 | 2012 Oct |
| 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. | Chen, Haijun; Tsalkova, Tamara; Mei, Fang C; Hu, Yaohua; Cheng, Xiaodong; Zhou, Jia | Bioorganic & medicinal chemistry letters | 22607683 | 2012 Jun 15 |
| Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. | Sheffler, Douglas J; Wenthur, Cody J; Bruner, Joshua A; Carrington, Sheridan J S; Vinson, Paige N; Gogi, Kiran K; Blobaum, Anna L; Morrison, Ryan D; Vamos, Mitchell; Cosford, Nicholas D P; Stauffer, Shaun R; Daniels, J Scott; Niswender, Colleen M; Conn, P | Bioorganic & medicinal chemistry letters | 22607673 | 2012 Jun 15 |
| Bicyclic C21 terpenoids from the marine sponge Clathria compressa. | Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; McLean, Amanda B; Robins, Allan J; West, Lyndon M | Journal of natural products | 22607472 | 2012 Jun 22 |
| Pyrazolopyridines as inhibitors of the kinase LRRK2: a patent evaluation (WO2011141756). | Deng, Xianming; S Gray, Nathanael | Expert opinion on therapeutic patents | 22607035 | 2012 Jun |
| Non-iminosugar glucocerebrosidase small molecule chaperones. | Marugan, Juan Jose; Huang, Wenwei; Motabar, Omid; Zheng, Wei; Xiao, Jingbo; Patnaik, Samarjit; Southall, Noel; Westbroek, Wendy; Lea, Wendy A; Simeonov, Anton; Goldin, Ehud; Debernardi, Maria A; Sidransky, Ellen | MedChemComm | 22606365 | 2012 Jan |
| A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis. | Yang, Ruojing; Lacson, Raul G; Castriota, Gino; Zhang, Xiaohua D; Liu, Yaping; Zhao, Wenqing; Einstein, Monica; Camargo, Luiz Miguel; Qureshi, Sajjad; Wong, Kenny K; Zhang, Bei B; Ferrer, Marc; Berger, Joel P | PloS one | 22590537 | 2012 |
| Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. | Herman, Ariel G; Hayano, Miki; Poyurovsky, Masha V; Shimada, Kenichi; Skouta, Rachid; Prives, Carol; Stockwell, Brent R | Cancer discovery | 22586610 | 2011 Sep |
| Chiral aminophosphines as catalysts for enantioselective double-Michael indoline syntheses. | Khong, San N; Kwon, Ohyun | Molecules (Basel, Switzerland) | 22580397 | 2012 |
| Nanofiber-based delivery of bioactive agents and stem cells to bone sites. | Zhang, Zhanpeng; Hu, Jiang; Ma, Peter X | Advanced drug delivery reviews | 22579758 | 2012 Sep |
| Parallel synthesis of peptide-like macrocycles containing imidazole-4,5-dicarboxylic acid. | Xu, Zhigang; Wheeler, Kraig A; Baures, Paul W | Molecules (Basel, Switzerland) | 22569415 | 2012 |
| Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction. | Ji, Cheng; Lin, Weimin; Moraski, Garrett C; Thanassi, Jane A; Pucci, Michael J; Franzblau, Scott G; Mollmann, Ute; Miller, Marvin J | Bioorganic & medicinal chemistry | 22560837 | 2012 Jun 1 |
| Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges. | Vugmeyster, Yulia; Xu, Xin; Theil, Frank-Peter; Khawli, Leslie A; Leach, Michael W | World journal of biological chemistry | 22558487 | 2012 Apr 26 |
| Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase. | Lea, Wendy A; Simeonov, Anton | PloS one | 22558390 | 2012 |
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| Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. | Shukla, Sunita J; Huang, Ruili; Simmons, Steven O; Tice, Raymond R; Witt, Kristine L; Vanleer, Danielle; Ramabhadran, Ram; Austin, Christopher P; Xia, Menghang | Environmental health perspectives | 22551509 | 2012 Aug |
| Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids. | Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen F | Tetrahedron letters | 22544982 | 2012 Feb 1 |
| Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles. | Shaw, Arthur Y; McLaren, Jonathan A; Nichol, Gary S; Hulme, Christopher | Tetrahedron letters | 22544981 | 2012 May 23 |
| A self-produced trigger for biofilm disassembly that targets exopolysaccharide. | Kolodkin-Gal, Ilana; Cao, Shugeng; Chai, Liraz; Bottcher, Thomas; Kolter, Roberto; Clardy, Jon; Losick, Richard | Cell | 22541437 | 2012 Apr 27 |
| Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer. | LaValle, Courtney R; Zhang, Liyong; Xu, Shuping; Eiseman, Julie L; Wang, Q Jane | Molecular cancer therapeutics | 22532599 | 2012 Jul |
| Identification of drug modulators targeting gene-dosage disease CMT1A. | Jang, Sung-Wook; Lopez-Anido, Camila; MacArthur, Ryan; Svaren, John; Inglese, James | ACS chemical biology | 22530759 | 2012 Jul 20 |
| Paradigm shift in toxicity testing and modeling. | Sun, Hongmao; Xia, Menghang; Austin, Christopher P; Huang, Ruili | The AAPS journal | 22528508 | 2012 Sep |
| Phosphine-catalyzed intramolecular ýý-umpolung addition of ýý-aminoalkylallenic esters: facile synthesis of 3-carbethoxy-2-alkyl-3-pyrrolines. | Andrews, Ian P; Blank, Brian R; Kwon, Ohyun | Chemical communications (Cambridge, England) | 22526463 | 2012 May 28 |
| Nitrosation of aryl and heteroaryltrifluoroborates with nitrosonium tetrafluoroborate. | Molander, Gary A; Cavalcanti, Livia N | The Journal of organic chemistry | 22524190 | 2012 May 4 |
| RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes. | Zaretzki, Jed; Rydberg, Patrik; Bergeron, Charles; Bennett, Kristin P; Olsen, Lars; Breneman, Curt M | Journal of chemical information and modeling | 22524152 | 2012 Jun 25 |
| Small-molecule inhibitors of the c-Fes protein-tyrosine kinase. | Hellwig, Sabine; Miduturu, Chandra V; Kanda, Shigeru; Zhang, Jianming; Filippakopoulos, Panagis; Salah, Eidarus; Deng, Xianming; Choi, Hwan Geun; Zhou, Wenjun; Hur, Wooyoung; Knapp, Stefan; Gray, Nathanael S; Smithgall, Thomas E | Chemistry & biology | 22520759 | 2012 Apr 20 |
| Microbial strain prioritization using metabolomics tools for the discovery of natural products. | Hou, Yanpeng; Braun, Doug R; Michel, Cole R; Klassen, Jonathan L; Adnani, Navid; Wyche, Thomas P; Bugni, Tim S | Analytical chemistry | 22519562 | 2012 May 15 |
| Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform. | Dai, Tianhong; Fuchs, Beth B; Coleman, Jeffrey J; Prates, Renato A; Astrakas, Christos; St Denis, Tyler G; Ribeiro, Martha S; Mylonakis, Eleftherios; Hamblin, Michael R; Tegos, George P | Frontiers in microbiology | 22514547 | 2012 |
| Vacuolar H+-ATPase (V-ATPase) promotes vacuolar membrane permeabilization and nonapoptotic death in stressed yeast. | Kim, Hyemin; Kim, Adam; Cunningham, Kyle W | The Journal of biological chemistry | 22511765 | 2012 Jun 1 |
| Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor. | Melancon, Bruce J; Gogliotti, Rocco D; Tarr, James C; Saleh, Sam A; Chauder, Brian A; Lebois, Evan P; Cho, Hyekyung P; Utley, Thomas J; Sheffler, Douglas J; Bridges, Thomas M; Morrison, Ryan D; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lind | Bioorganic & medicinal chemistry letters | 22507963 | 2012 May 15 |
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| Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. | Dillon, Myles B C; Bachovchin, Daniel A; Brown, Steven J; Finn, M G; Rosen, Hugh; Cravatt, Benjamin F; Mowen, Kerri A | ACS chemical biology | 22506763 | 2012 Jul 20 |
| Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. | Musille, Paul M; Pathak, Manish C; Lauer, Janelle L; Hudson, William H; Griffin, Patrick R; Ortlund, Eric A | Nature structural & molecular biology | 22504882 | 2012 May |
| High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them. | Lee, Chrissie Y; Johnson, Ronald L; Wichterman-Kouznetsova, Jennifer; Guha, Rajarshi; Ferrer, Marc; Tuzmen, Pinar; Martin, Scott E; Zhu, Wenge; DePamphilis, Melvin L | Methods (San Diego, Calif.) | 22503772 | 2012 Jun |
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| Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock. | Bucarey, Sergio A; Penn, Kevin; Paul, Lauren; Fenical, William; Jensen, Paul R | Applied and environmental microbiology | 22492446 | 2012 Jun |
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| Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines. | Donald, James R; Wood, Rebekah R; Martin, Stephen F | ACS combinatorial science | 22273436 | 2012 Feb 13 |
| High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. | Goldin, Ehud; Zheng, Wei; Motabar, Omid; Southall, Noel; Choi, Jae Hyuk; Marugan, Juan; Austin, Christopher P; Sidransky, Ellen | PloS one | 22272254 | 2012 |
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| Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines. | Xu, Zhigang; Shaw, Arthur Y; Dietrich, Justin; Cappelli, Alexandra P; Nichol, Gary; Hulme, Christopher | Molecular diversity | 22237832 | 2012 Feb |
| Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. | Liu, Jinping; Luo, Shukun; Zhao, Hongchang; Liao, Ji; Li, Jing; Yang, Chunying; Xu, Bo; Stern, David F; Xu, Xingzhi; Ye, Keqiong | Nucleic acids research | 22234877 | 2012 May |
| Enteractinococcus coprophilus gen. nov., sp. nov., of the family Micrococcaceae, isolated from Panthera tigris amoyensis faeces, and transfer of Yaniella fodinae Dhanjal et al. 2011 to the genus Enteractinococcus as Enteractinococcus fodinae comb. nov. | Cao, Yan-Ru; Jiang, Yi; Jin, Rong-Xian; Han, Li; He, Wen-Xiang; Li, You-Long; Huang, Xue-Shi; Xue, Quan-Hong | International journal of systematic and evolutionary microbiology | 22228667 | 2012 Nov |
| Disposition of human recombinant lubricin in naive rats and in a rat model of post-traumatic arthritis after intra-articular or intravenous administration. | Vugmeyster, Yulia; Wang, Qin; Xu, Xin; Harrold, John; Daugusta, Daren; Li, Jian; Zollner, Richard; Flannery, Carl R; Rivera-Bermudez, Moises A | The AAPS journal | 22228117 | 2012 Mar |
| Synthesis of a ýý-lactam library via formal cycloaddition of imines and substituted succinic anhydrides. | Tan, Darlene Q; Atherton, Amy L; Smith, Austin J; Soldi, Cristian; Hurley, Katherine A; Fettinger, James C; Shaw, Jared T | ACS combinatorial science | 22225535 | 2012 Mar 12 |
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| Current chemical biology approaches to interrogate protein methyltransferases. | Luo, Minkui | ACS chemical biology | 22220966 | 2012 Mar 16 |
| Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1. | Chen, Catherine Z; Sobczak, Krzysztof; Hoskins, Jason; Southall, Noel; Marugan, Juan J; Zheng, Wei; Thornton, Charles A; Austin, Christopher P | Analytical and bioanalytical chemistry | 22218462 | 2012 Feb |
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| Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease. | Geng, Haifeng; Whiteley, Grace; Ribbens, Jameson; Zheng, Wei; Southall, Noel; Hu, Xin; Marugan, Juan J; Ferrer, Marc; Maegawa, Gustavo H B | PloS one | 22216298 | 2011 |
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| Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). | Chan, Chun-Yuan; Prudom, Catherine; Raines, Summer M; Charkhzarrin, Sahba; Melman, Sandra D; De Haro, Leyma P; Allen, Chris; Lee, Samuel A; Sklar, Larry A; Parra, Karlett J | The Journal of biological chemistry | 22215674 | 2012 Mar 23 |
| Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ýýF508 cystic fibrosis transmembrane conductance regulator protein. | Knapp, John M; Wood, Alex B; Phuan, Puay-Wah; Lodewyk, Michael W; Tantillo, Dean J; Verkman, A S; Kurth, Mark J | Journal of medicinal chemistry | 22214395 | 2012 Feb 9 |
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| Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. | Dower, Ken; Filone, Claire Marie; Hodges, Erin N; Bjornson, Zach B; Rubins, Kathleen H; Brown, Lauren E; Schaus, Scott; Hensley, Lisa E; Connor, John H | Journal of virology | 22205744 | 2012 Mar |
| The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. | Holmes, Ann R; Keniya, Mikhail V; Ivnitski-Steele, Irena; Monk, Brian C; Lamping, Erwin; Sklar, Larry A; Cannon, Richard D | Antimicrobial agents and chemotherapy | 22203607 | 2012 Mar |
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| Inhibition of the NF-ýýB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. | Olivera, Anlys; Moore, Terry W; Hu, Fang; Brown, Andrew P; Sun, Aiming; Liotta, Dennis C; Snyder, James P; Yoon, Younghyoun; Shim, Hyunsuk; Marcus, Adam I; Miller, Andrew H; Pace, Thaddeus W W | International immunopharmacology | 22197802 | 2012 Feb |
| Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. | Melancon, Bruce J; Lamers, Alexander P; Bridges, Thomas M; Sulikowski, Gary A; Utley, Thomas J; Sheffler, Douglas J; Noetzel, Meredith J; Morrison, Ryan D; Scott Daniels, J; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Wood, | Bioorganic & medicinal chemistry letters | 22197142 | 2012 Jan 15 |
| Design of triazole-stapled BCL9 ýý-helical peptides to target the ýý-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction. | Kawamoto, Steven A; Coleska, Adriana; Ran, Xu; Yi, Han; Yang, Chao-Yie; Wang, Shaomeng | Journal of medicinal chemistry | 22196480 | 2012 Feb 9 |
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| Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. | Ni, Terri T; Rellinger, Eric J; Mukherjee, Amrita; Xie, Shuying; Stephens, Lauren; Thorne, Curtis A; Kim, Kwangho; Hu, Jiangyong; Lee, Ethan; Marnett, Larry; Hatzopoulos, Antonis K; Zhong, Tao P | Chemistry & biology | 22195568 | 2011 Dec 23 |
| Simultaneous measurement of 10,000 protein-ligand affinity constants using microarray-based kinetic constant assays. | Landry, James P; Fei, Yiyan; Zhu, Xiangdong | Assay and drug development technologies | 22192305 | 2012 Jun |
| ýýýýC magnetic resonance spectroscopy detection of changes in serine isotopomers reflects changes in mitochondrial redox status. | Johnson, C Bryce; Tikunov, Andrey P; Lee, Haakil; Wolak, Justyna E; Pediaditakis, Peter; Romney, Doug A; Holmuhamedov, Ekhson; Gamcsik, Michael P; Macdonald, Jeffrey M | Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 22190282 | 2012 Sep |
| Is RORýý a therapeutic target for treating Mycobacterium tuberculosis infections? | Baures, Paul W | Tuberculosis (Edinburgh, Scotland) | 22186085 | 2012 Jan |
| Expedient synthesis of a 72-membered isoxazolino-*-ketoamide library by a 2ýý3-component reaction. | Knapp, John M; Zhu, Jie S; Wood, Alex B; Kurth, Mark J | ACS combinatorial science | 22181856 | 2012 Feb 13 |
| Omegatides: constrained analogs of peptide primary sequence. | Fedoseyenko, Dmytro; Raghuraman, Arjun; Ko, Eunhwa; Burgess, Kevin | Organic & biomolecular chemistry | 22179815 | 2012 Feb 7 |
| Microbial metabolic exchange--the chemotype-to-phenotype link. | Phelan, Vanessa V; Liu, Wei-Ting; Pogliano, Kit; Dorrestein, Pieter C | Nature chemical biology | 22173357 | 2012 Jan |
| Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. | Theriault, Jimmy R; Felts, Andrew S; Bates, Brittney S; Perez, Jose R; Palmer, Michelle; Gilbert, Shawn R; Dawson, Eric S; Engers, Julie L; Lindsley, Craig W; Emmitte, Kyle A | Bioorganic & medicinal chemistry letters | 22172704 | 2012 Jan 1 |
| Quantitative high-throughput drug screening identifies novel classes of drugs with anticancer activity in thyroid cancer cells: opportunities for repurposing. | Zhang, Lisa; He, Mei; Zhang, Yaqin; Nilubol, Naris; Shen, Min; Kebebew, Electron | The Journal of clinical endocrinology and metabolism | 22170715 | 2012 Mar |
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| Phospholipase D as a therapeutic target in brain disorders. | Lindsley, Craig W; Brown, H Alex | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology | 22157867 | 2012 Jan |
| Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model. | Costello, Leslie C; Franklin, Renty B; Zou, Jing; Feng, Pei; Bok, Robert; Swanson, Mark G; Kurhanewicz, John | Cancer biology & therapy | 22156800 | 2011 Dec 15 |
| High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1. | Zhai, Dayong; Godoi, Paulo; Sergienko, Eduard; Dahl, Russell; Chan, Xochella; Brown, Brock; Rascon, Justin; Hurder, Andrew; Su, Ying; Chung, Thomas D Y; Jin, Chaofang; Diaz, Paul; Reed, John C | Journal of biomolecular screening | 22156224 | 2012 Mar |
| Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. | Yeung, Jennifer; Apopa, Patrick L; Vesci, Joanne; Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Simeonov, Anton; Holman, Theodore R; Maloney, David J; Boutaud, Olivier; Holinstat, Michael | Molecular pharmacology | 22155783 | 2012 Mar |
| MCR synthesis of praziquantel derivatives. | Liu, Haixia; William, Samia; Herdtweck, Eberhardt; Botros, Sanaa; Domling, Alexander | Chemical biology & drug design | 22151001 | 2012 Apr |
| Genetic evidence for natural product-mediated plant-plant allelopathy in rice (Oryza sativa). | Xu, Meimei; Galhano, Rita; Wiemann, Philipp; Bueno, Emilio; Tiernan, Mollie; Wu, William; Chung, Ill-Min; Gershenzon, Jonathan; Tudzynski, Bettina; Sesma, Ane; Peters, Reuben J | The New phytologist | 22150231 | 2012 Feb |
| hERGCentral: a large database to store, retrieve, and analyze compound-human Ether-a-go-go related gene channel interactions to facilitate cardiotoxicity assessment in drug development. | Du, Fang; Yu, Haibo; Zou, Beiyan; Babcock, Joseph; Long, Shunyou; Li, Min | Assay and drug development technologies | 22149888 | 2011 Dec |
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| Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. | Chen, Junjun; Dexheimer, Thomas S; Ai, Yongxing; Liang, Qin; Villamil, Mark A; Inglese, James; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Zhuang, Zhihao | Chemistry & biology | 22118673 | 2011 Nov 23 |
| Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'. | Freel, Kelle C; Edlund, Anna; Jensen, Paul R | Environmental microbiology | 22117917 | 2012 Feb |
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| Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out. | Organ, Michael G; Hanson, Paul R; Rolfe, Alan; Samarakoon, Thiwanka B; Ullah, Farman | Journal of flow chemistry | 22116791 | 2011 Aug |
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| Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A. | Cardellina 2nd, John H; Vieira, Rebecca C; Eccard, Vanessa; Skerry, Janet; Montgomery, Vicki; Campbell, Yvette; Roxas-Duncan, Virginia; Leister, William; Leclair, Christopher A; Maloney, David J; Padula, Daniele; Pescitelli, Gennaro; Khavrutskii, Ilja; Hu, Xin; Wallqvist, Anders; Smith, Leonard A | ACS medicinal chemistry letters | 22102940 | 2011 Mar 10 |
| Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. | Yang, Chunying; Tang, Xi; Guo, Xiaojing; Niikura, Yohei; Kitagawa, Katsumi; Cui, Kemi; Wong, Stephen T C; Fu, Li; Xu, Bo | Molecular cell | 22099307 | 2011 Nov 18 |
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| The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. | Jones, Carrie K; Bubser, Michael; Thompson, Analisa D; Dickerson, Jonathan W; Turle-Lorenzo, Nathalie; Amalric, Marianne; Blobaum, Anna L; Bridges, Thomas M; Morrison, Ryan D; Jadhav, Satyawan; Engers, Darren W; Italiano, Kimberly; Bode, Jacob; Daniels, J | The Journal of pharmacology and experimental therapeutics | 22088953 | 2012 Feb |
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| A miniature Couette to generate shear for flow cytometry: studying real-time modulation of intracellular calcium in monocytic cells. | Zwartz, Gordon J; Chigaev, Alexandre; Foutz, Terry D; Edwards, Bruce; Sklar, Larry A | Cytometry. Part A : the journal of the International Society for Analytical Cytology | 22045643 | 2011 Mar |
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| Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design. | Cai, Lifeng; Gochin, Miriam; Liu, Keliang | Current topics in medicinal chemistry | 22044229 | 2011 Dec |
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| Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy. | Granger, Brett A; Kaneda, Kyosuke; Martin, Stephen F | ACS combinatorial science | 22040015 | 2012 Jan 9 |
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| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Anastassiadis, Theonie; Deacon, Sean W; Devarajan, Karthik; Ma, Haiching; Peterson, Jeffrey R | Nature biotechnology | 22037377 | 2011 Nov |
| Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. | Lewin, Anita H; Miller, Gregory M; Gilmour, Brian | Bioorganic & medicinal chemistry | 22037049 | 2011 Dec 1 |
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| Multiplex de novo sequencing of peptide antibiotics. | Mohimani, Hosein; Liu, Wei-Ting; Yang, Yu-Liang; Gaudencio, Susana P; Fenical, William; Dorrestein, Pieter C; Pevzner, Pavel A | Journal of computational biology : a journal of computational molecular cell biology | 22035290 | 2011 Nov |
| Functional fluorescently labeled bithiazole ýýF508-CFTR corrector imaged in whole body slices in mice. | Davison, Holly R; Taylor, Stephanie; Drake, Chris; Phuan, Puay-Wah; Derichs, Nico; Yao, Chenjuan; Jones, Ella F; Sutcliffe, Julie; Verkman, A S; Kurth, Mark J | Bioconjugate chemistry | 22034937 | 2011 Dec 21 |
| TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors. | Madiraju, Charitha; Welsh, Kate; Cuddy, Michael P; Godoi, Paulo H; Pass, Ian; Ngo, Tram; Vasile, Stefan; Sergienko, Eduard A; Diaz, Paul; Matsuzawa, Shu-Ichi; Reed, John C | Journal of biomolecular screening | 22034497 | 2012 Feb |
| A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide. | Motabar, Omid; Goldin, Ehud; Leister, William; Liu, Ke; Southall, Noel; Huang, Wenwei; Marugan, Juan J; Sidransky, Ellen; Zheng, Wei | Analytical and bioanalytical chemistry | 22033823 | 2012 Jan |
| S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. | Gonzalez-Cabrera, Pedro J; Cahalan, Stuart M; Nguyen, Nhan; Sarkisyan, Gor; Leaf, Nora B; Cameron, Michael D; Kago, Tomoyuki; Rosen, Hugh | Molecular pharmacology | 22031473 | 2012 Feb |
| Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator. | Utley, Thomas; Haddenham, Dustin; Salovich, James M; Zamorano, Rocio; Vinson, Paige N; Lindsley, Craig W; Hopkins, Corey R; Niswender, Colleen M | Bioorganic & medicinal chemistry letters | 22030026 | 2011 Dec 1 |
| Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. | Chan, Lai N; Fiji, Hannah D G; Watanabe, Masaru; Kwon, Ohyun; Tamanoi, Fuyuhiko | PloS one | 22028818 | 2011 |
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| Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds. | Roth, Joshua; Minond, Dmitriy; Darout, Etzer; Liu, Qin; Lauer, Janelle; Hodder, Peter; Fields, Gregg B; Roush, William R | Bioorganic & medicinal chemistry letters | 22018790 | 2011 Dec 1 |
| Identification of small-molecule inhibitors of Trypansoma cruzi replication. | Germain, Andrew R; Carmody, Leigh C; Dockendorff, Chris; Galan-Rodriguez, Cristina; Rodriguez, Ana; Johnston, Stephen; Bittker, Joshua A; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Schreiber, Stuart L; Munoz, Benito | Bioorganic & medicinal chemistry letters | 22018462 | 2011 Dec 1 |
| Fluorescent labeling agents change binding profiles of glycan-binding proteins. | Fei, Yiyan; Sun, Yung-Shin; Li, Yanhong; Lau, Kam; Yu, Hai; Chokhawala, Harshal A; Huang, Shengshu; Landry, James P; Chen, Xi; Zhu, Xiangdong | Molecular bioSystems | 22009201 | 2011 Dec |
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| Smardaesidins A-G, isopimarane and 20-nor-isopimarane diterpenoids from Smardaea sp., a fungal endophyte of the moss Ceratodon purpureus. | Wang, Xiao-Ning; Bashyal, Bharat P; Wijeratne, E M Kithsiri; U'Ren, Jana M; Liu, Manping X; Gunatilaka, Malkanthi K; Arnold, A Elizabeth; Gunatilaka, A A Leslie | Journal of natural products | 21999655 | 2011 Oct 28 |
| Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. | Liu, Wei-Ting; Kersten, Roland D; Yang, Yu-Liang; Moore, Bradley S; Dorrestein, Pieter C | Journal of the American Chemical Society | 21999343 | 2011 Nov 16 |
| Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on. | O'Boyle, Noel M; Guha, Rajarshi; Willighagen, Egon L; Adams, Samuel E; Alvarsson, Jonathan; Bradley, Jean-Claude; Filippov, Igor V; Hanson, Robert M; Hanwell, Marcus D; Hutchison, Geoffrey R; James, Craig A; Jeliazkova, Nina; Lang, Andrew Sid; Langner, Karol M; Lonie, David C; Lowe, Daniel M; Pansanel, Jerome; Pavlov, Dmitry; Spjuth, Ola; Steinbeck, Christoph; Tenderholt, Adam L; Theisen, Kevin J; Murray-Rust, Peter | Journal of cheminformatics | 21999342 | 2011 |
| Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. | Sharlow, Elizabeth R; Mustata Wilson, Gabriela; Close, David; Leimgruber, Stephanie; Tandon, Manuj; Reed, Robyn B; Shun, Tong Ying; Wang, Q Jane; Wipf, Peter; Lazo, John S | PloS one | 21998636 | 2011 |
| Palladium(II)-catalyzed dehydrogenative alkenylation of cyclic enaminones via the Fujiwara-Moritani reaction. | Yu, Yi-Yun; Niphakis, Micah J; Georg, Gunda I | Organic letters | 21995751 | 2011 Nov 4 |
| Synthesis of caeliferins, elicitors of plant immune responses: accessing lipophilic natural products via cross metathesis. | O'Doherty, Inish; Yim, Joshua J; Schmelz, Eric A; Schroeder, Frank C | Organic letters | 21992613 | 2011 Nov 4 |
| Enantioselective and regioselective indium(III)-catalyzed addition of pyrroles to isatins. | Gutierrez, Elisa G; Wong, Casey J; Sahin, Aziza H; Franz, Annaliese K | Organic letters | 21992567 | 2011 Nov 4 |
| The BioAssay network and its implications to future therapeutic discovery. | Zhang, Jintao; Lushington, Gerald H; Huan, Jun | BMC bioinformatics | 21988927 | 2011 |
| Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7. | Wu, Yisheng; Hillwig, Matthew L; Wang, Qiang; Peters, Reuben J | FEBS letters | 21985968 | 2011 Nov 4 |
| A mass spectrometry-guided genome mining approach for natural product peptidogenomics. | Kersten, Roland D; Yang, Yu-Liang; Xu, Yuquan; Cimermancic, Peter; Nam, Sang-Jip; Fenical, William; Fischbach, Michael A; Moore, Bradley S; Dorrestein, Pieter C | Nature chemical biology | 21983601 | 2011 Nov |
| Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1. | Qiao, Kangjian; Chooi, Yit-Heng; Tang, Yi | Metabolic engineering | 21983160 | 2011 Nov |
| Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. | Urbano, Mariangela; Guerrero, Miguel; Velaparthi, Subash; Crisp, Melissa; Chase, Peter; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward | Bioorganic & medicinal chemistry letters | 21982495 | 2011 Nov 15 |
| Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome. | Mestres, J; Seifert, S A; Oprea, T I | Clinical pharmacology and therapeutics | 21975349 | 2011 Nov |
| Parsimonious discovery of synergistic drug combinations. | Severyn, Bryan; Liehr, Robert A; Wolicki, Alex; Nguyen, Kevin H; Hudak, Edward M; Ferrer, Marc; Caldwell, Jeremy S; Hermes, Jeffrey D; Li, Jing; Tudor, Matthew | ACS chemical biology | 21974780 | 2011 Dec 16 |
| All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease. | St Denis, Tyler G; Dai, Tianhong; Izikson, Leonid; Astrakas, Christos; Anderson, Richard Rox; Hamblin, Michael R; Tegos, George P | Virulence | 21971183 | 2011 Nov-Dec |
| A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. | Chang, Jerry C; Tomlinson, Ian D; Warnement, Michael R; Iwamoto, Hideki; DeFelice, Louis J; Blakely, Randy D; Rosenthal, Sandra J | Journal of the American Chemical Society | 21970724 | 2011 Nov 9 |
| Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes. | Fang, Yuesi; Wu, Chunrui; Larock, Richard C; Shi, Feng | The Journal of organic chemistry | 21970468 | 2011 Nov 4 |
| Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 ( | Jones, Carrie K; Engers, Darren W; Thompson, Analisa D; Field, Julie R; Blobaum, Anna L; Lindsley, Stacey R; Zhou, Ya; Gogliotti, Rocco D; Jadhav, Satyawan; Zamorano, Rocio; Bogenpohl, Jim; Smith, Yoland; Morrison, Ryan; Daniels, J Scott; Weaver, C David; | Journal of medicinal chemistry | 21966889 | 2011 Nov 10 |
| Methods for Activity Analysis of the Proteins that Regulate Histone Methylation. | Quinn AM, Simeonov A. | Curr Chem Genomics | 21966349 | 2011 |
| Multiplexed Analysis of Peptide Functionality Using Lanthanide-based Structural Shift Reagents. | Kerr, Thomas J; Gant-Branum, Randi L; McLean, John A | International journal of mass spectrometry | 21966243 | 2011 Oct 1 |
| Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice. | Thomsen, Morgane; Lindsley, Craig W; Conn, P Jeffrey; Wessell, Jeffrey E; Fulton, Brian S; Wess, Jurgen; Caine, S Barak | Psychopharmacology | 21964721 | 2012 Apr |
| Is prolonged stem cell mobilization detrimental for hematopoiesis? | Chigaev, Alexandre; Winter, Stuart S; Sklar, Larry A | Medical hypotheses | 21963354 | 2011 Dec |
| Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. | Lebois, Evan P; Bridges, Thomas M; Lewis, L Michelle; Dawson, Eric S; Kane, Alexander S; Xiang, Zixiu; Jadhav, Satyawan B; Yin, Huiyong; Kennedy, J Phillip; Meiler, Jens; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Weaver, C David; Lindsley, C | ACS chemical neuroscience | 21961051 | 2010 |
| 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. | Walsh, Martin J; Brimacombe, Kyle R; Veith, Henrike; Bougie, James M; Daniel, Thomas; Leister, William; Cantley, Lewis C; Israelsen, William J; Vander Heiden, Matthew G; Shen, Min; Auld, Douglas S; Thomas, Craig J; Boxer, Matthew B | Bioorganic & medicinal chemistry letters | 21958545 | 2011 Nov 1 |
| caCORRECT2: Improving the accuracy and reliability of microarray data in the presence of artifacts. | Moffitt, Richard A; Yin-Goen, Qiqin; Stokes, Todd H; Parry, R Mitchell; Torrance, James H; Phan, John H; Young, Andrew N; Wang, May D | BMC bioinformatics | 21957981 | 2011 |
| Cell targeting with hybrid Qýý virus-like particles displaying epidermal growth factor. | Pokorski, Jonathan K; Hovlid, Marisa L; Finn, M G | Chembiochem : a European journal of chemical biology | 21956837 | 2011 Nov 4 |
| Workflow and metrics for image quality control in large-scale high-content screens. | Bray, Mark-Anthony; Fraser, Adam N; Hasaka, Thomas P; Carpenter, Anne E | Journal of biomolecular screening | 21956170 | 2012 Feb |
| High throughput flow cytometry based yeast two-hybrid array approach for large-scale analysis of protein-protein interactions. | Chen, Jun; Carter, Mark B; Edwards, Bruce S; Cai, Hong; Sklar, Larry A | Cytometry. Part A : the journal of the International Society for Analytical Cytology | 21954189 | 2012 Jan |
| Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. | Huang, Yijun; Wolf, Siglinde; Koes, David; Popowicz, Grzegorz M; Camacho, Carlos J; Holak, Tad A; Domling, Alexander | ChemMedChem | 21954050 | 2012 Jan 2 |
| Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. | de la Paz Santangelo, Maria; Gest, Petra M; Guerin, Marcelo E; Coincon, Mathieu; Pham, Ha; Ryan, Gavin; Puckett, Susan E; Spencer, John S; Gonzalez-Juarrero, Mercedes; Daher, Racha; Lenaerts, Anne J; Schnappinger, Dirk; Therisod, Michel; Ehrt, Sabine; Syg | The Journal of biological chemistry | 21949126 | 2011 Nov 18 |
| High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. | Seguin, Sandlin P; Evans, Carrie W; Nebane-Akah, Miranda; McKellip, Sara; Ananthan, Subramaniam; Tower, Nichole A; Sosa, Melinda; Rasmussen, Lynn; White, E Lucile; Maki, Brooks E; Matharu, Daljit S; Golden, Jennifer E; Aube, Jeffrey; Brodsky, Jeffrey L; N | Journal of biomolecular screening | 21948801 | 2012 Feb |
| Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. | Crawford, Jason M; Mahlstedt, Sarah A; Malcolmson, Steven J; Clardy, Jon; Walsh, Christopher T | Chemistry & biology | 21944749 | 2011 Sep 23 |
| A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes. | Peatey, Christopher L; Spicer, Timothy P; Hodder, Peter S; Trenholme, Katharine R; Gardiner, Donald L | Molecular and biochemical parasitology | 21939693 | 2011 Dec |
| Direct Hiyama cross-coupling of enaminones with triethoxy(aryl)silanes and dimethylphenylsilanol. | Bi, Lei; Georg, Gunda I | Organic letters | 21939201 | 2011 Oct 21 |
| Phospholipase D: enzymology, functionality, and chemical modulation. | Selvy, Paige E; Lavieri, Robert R; Lindsley, Craig W; Brown, H Alex | Chemical reviews | 21936578 | 2011 Oct 12 |
| Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. | Naidu, Mamta D; Agarwal, Rakhi; Pena, Louis A; Cunha, Luis; Mezei, Mihaly; Shen, Min; Wilson 3rd, David M; Liu, Yuan; Sanchez, Zina; Chaudhary, Pankaj; Wilson, Samuel H; Waring, Michael J | PloS one | 21935361 | 2011 |
| Phosphine-initiated general base catalysis: facile access to benzannulated 1,3-diheteroatom five-membered rings via double-Michael reactions of allenes. | Szeto, Judy; Sriramurthy, Vardhineedi; Kwon, Ohyun | Organic letters | 21932819 | 2011 Oct 21 |
| Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice. | Dai, Tianhong; Bil de Arce, Vida J; Tegos, George P; Hamblin, Michael R | Antimicrobial agents and chemotherapy | 21930868 | 2011 Dec |
| Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet. | Benninger, R K P; Head, W Steven; Zhang, Min; Satin, Leslie S; Piston, David W | The Journal of physiology | 21930600 | 2011 Nov 15 |
| Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. | Lebois, Evan P; Digby, Gregory J; Sheffler, Douglas J; Melancon, Bruce J; Tarr, James C; Cho, Hyekyung P; Miller, Nicole R; Morrison, Ryan; Bridges, Thomas M; Xiang, Zixiu; Scott Daniels, J; Wood, Michael R; Conn, P Jeffrey; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 21930376 | 2011 Nov 1 |
| Development of indole compounds as small molecule fusion inhibitors targeting HIV-1 glycoprotein-41. | Zhou, Guangyan; Wu, Dong; Snyder, Beth; Ptak, Roger G; Kaur, Harmeet; Gochin, Miriam | Journal of medicinal chemistry | 21928824 | 2011 Oct 27 |
| Roseobacticides: small molecule modulators of an algal-bacterial symbiosis. | Seyedsayamdost, Mohammad R; Carr, Gavin; Kolter, Roberto; Clardy, Jon | Journal of the American Chemical Society | 21928816 | 2011 Nov 16 |
| Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis. | Chou, Danny Hung-Chieh; Duvall, Jeremy R; Gerard, Baudouin; Liu, Haibo; Pandya, Bhaumik A; Suh, Byung-Chul; Forbeck, Erin M; Faloon, Patrick; Wagner, Bridget K; Marcaurelle, Lisa A | ACS medicinal chemistry letters | 21927648 | 2011 Sep 8 |
| Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. | Zang, Qin; Javed, Salim; Ullah, Farman; Zhou, Aihua; Knudtson, Christopher A; Bi, Danse; Basha, Fatima Z; Organ, Michael G; Hanson, Paul R | Synthesis | 21927510 | 2011 Sep 1 |
| Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. | Teijaro, John R; Walsh, Kevin B; Cahalan, Stuart; Fremgen, Daniel M; Roberts, Edward; Scott, Fiona; Martinborough, Esther; Peach, Robert; Oldstone, Michael B A; Rosen, Hugh | Cell | 21925319 | 2011 Sep 16 |
| Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport. | Daghestani, Hikmat N; Zhu, Guangyu; Johnston, Paul A; Shinde, Sunita N; Brodsky, Jeffrey L; Day, Billy W | Assay and drug development technologies | 21919741 | 2012 Feb |
| Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent. | Liu, Guanshu; Liang, Yajie; Bar-Shir, Amnon; Chan, Kannie W Y; Galpoththawela, Chulani S; Bernard, Segun M; Tse, Terence; Yadav, Nirbhay N; Walczak, Piotr; McMahon, Michael T; Bulte, Jeff W M; van Zijl, Peter C M; Gilad, Assaf A | Journal of the American Chemical Society | 21919523 | 2011 Oct 19 |
| Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening. | Andriani, Grasiella; Chessler, Anne-Danielle C; Courtemanche, Gilles; Burleigh, Barbara A; Rodriguez, Ana | PLoS neglected tropical diseases | 21912715 | 2011 Aug |
| Overview: assays for studying integrin-dependent cell adhesion. | Chigaev, Alexandre; Sklar, Larry A | Methods in molecular biology (Clifton, N.J.) | 21909902 | 2012 |
| Exploring protein superstructures and dynamics in live bacterial cells using single-molecule and superresolution imaging. | Biteen, Julie S; Shapiro, Lucy; Moerner, W E | Methods in molecular biology (Clifton, N.J.) | 21909887 | 2011 |
| Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. | Sun, Hongmao; Veith, Henrike; Xia, Menghang; Austin, Christopher P; Huang, Ruili | Journal of chemical information and modeling | 21905670 | 2011 Oct 24 |
| Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype. | Vidovic, Dusica; Xie, Yuli; Rinderspacher, Alison; Deng, Shi-Xian; Landry, Donald W; Chung, Caty; Smith, Deborah H; Tautz, Lutz; Schurer, Stephan C | Journal of computer-aided molecular design | 21904909 | 2011 Sep |
| Transannular Anti-Michael Addition: Formation of 4H-Pyrazolo[5,1-c]thiazines. | Suen, Yat Fan; Hope, Hakon; Nantz, Michael H; Haddadin, Makhluf J; Kurth, And Mark J | Tetrahedron letters | 21904417 | 2006 Nov 6 |
| Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria. | Tang, M; Odejinmi, S I; Allette, Y M; Vankayalapati, H; Lai, K | Bioorganic & medicinal chemistry | 21903402 | 2011 Oct 1 |
| A brief survey of mRNA surveillance. | van Hoof, Ambro; Wagner, Eric J | Trends in biochemical sciences | 21903397 | 2011 Nov |
| Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. | Rolfe, Alan; Ullah, Farman; Samarakoon, Thiwanka B; Kurtz, Ryan D; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R | ACS combinatorial science | 21902243 | 2011 Nov 14 |
| Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm. | Walsh, Kevin B; Teijaro, John R; Rosen, Hugh; Oldstone, Michael B A | Immunologic research | 21901448 | 2011 Oct |
| Optimization and application of median filter corrections to relieve diverse spatial patterns in microtiter plate data. | Bushway, Paul J; Azimi, Behrad; Heynen-Genel, Susanne | Journal of biomolecular screening | 21900202 | 2011 Oct |
| Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. | Tsuboi, Katsunori; Bachovchin, Daniel A; Speers, Anna E; Spicer, Timothy P; Fernandez-Vega, Virneliz; Hodder, Peter; Rosen, Hugh; Cravatt, Benjamin F | Journal of the American Chemical Society | 21899313 | 2011 Oct 19 |
| A modular reaction pairing approach to the diversity-oriented synthesis of fused- and bridged-polycyclic sultams. | Samarakoon, Thiwanka B; Loh, Joanna K; Rolfe, Alan; Le, Lisa S; Yoon, Sun Young; Lushington, Gerald H; Hanson, Paul R | Organic letters | 21899284 | 2011 Oct 7 |
| Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. | Ames, Brian D; Haynes, Stuart W; Gao, Xue; Evans, Bradley S; Kelleher, Neil L; Tang, Yi; Walsh, Christopher T | Biochemistry | 21899262 | 2011 Oct 11 |
| Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion. | Chamni, Supakarn; He, Qing-Li; Dang, Yongjun; Bhat, Shridhar; Liu, Jun O; Romo, Daniel | ACS chemical biology | 21894934 | 2011 Nov 18 |
| Antidiabetic actions of a non-agonist PPARýý ligand blocking Cdk5-mediated phosphorylation. | Choi, Jang Hyun; Banks, Alexander S; Kamenecka, Theodore M; Busby, Scott A; Chalmers, Michael J; Kumar, Naresh; Kuruvilla, Dana S; Shin, Youseung; He, Yuanjun; Bruning, John B; Marciano, David P; Cameron, Michael D; Laznik, Dina; Jurczak, Michael J; Schur | Nature | 21892191 | 2011 Sep 22 |
| Nonomuraea soli sp. nov., an actinomycete isolated from soil. | Cao, Yan-Ru; Jin, Rong-Xian; Jiang, Yi; He, Wen-Xiang; Jiang, Cheng-Lin | International journal of systematic and evolutionary microbiology | 21890732 | 2012 Jul |
| Ligand-dependent perturbation of the conformational ensemble for the GPCR ýý2 adrenergic receptor revealed by HDX. | West, Graham M; Chien, Ellen Y T; Katritch, Vsevolod; Gatchalian, Jovylyn; Chalmers, Michael J; Stevens, Raymond C; Griffin, Patrick R | Structure (London, England : 1993) | 21889352 | 2011 Oct 12 |
| NRPS substrate promiscuity diversifies the xenematides. | Crawford, Jason M; Portmann, Cyril; Kontnik, Renee; Walsh, Christopher T; Clardy, Jon | Organic letters | 21888371 | 2011 Oct 7 |
| Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening. | Bialkowska, Agnieszka B; Crisp, Melissa; Bannister, Thomas; He, Yuanjun; Chowdhury, Sarwat; Schurer, Stephan; Chase, Peter; Spicer, Timothy; Madoux, Franck; Tian, Chenlu; Hodder, Peter; Zaharevitz, Daniel; Yang, Vincent W | Molecular cancer therapeutics | 21885866 | 2011 Nov |
| The role of residue C410 on activation of the human vitamin D receptor by various ligands. | Castillo, Hilda S; Ousley, Amanda M; Duraj-Thatte, Anna; Lindstrom, Kelli N; Patel, Dina D; Bommarius, Andreas S; Azizi, Bahareh | The Journal of steroid biochemistry and molecular biology | 21884792 | 2012 Jan |
| Marine natural products: a new wave of drugs? | Montaser, Rana; Luesch, Hendrik | Future medicinal chemistry | 21882941 | 2011 Sep |
| Inhibition of marine biofouling by bacterial quorum sensing inhibitors. | Dobretsov, Sergey; Teplitski, Max; Bayer, Mirko; Gunasekera, Sarath; Proksch, Peter; Paul, Valerie J | Biofouling | 21882898 | 2011 Sep |
| Rank order entropy: why one metric is not enough. | McLellan, Margaret R; Ryan, M Dominic; Breneman, Curt M | Journal of chemical information and modeling | 21875058 | 2011 Sep 26 |
| Evolution of secondary metabolite genes in three closely related marine actinomycete species. | Freel, Kelle C; Nam, Sang-Jip; Fenical, William; Jensen, Paul R | Applied and environmental microbiology | 21873479 | 2011 Oct |
| Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. | Zhao, Li-Xing; Huang, Sheng-Xiong; Tang, Shu-Kun; Jiang, Cheng-Lin; Duan, Yanwen; Beutler, John A; Henrich, Curtis J; McMahon, James B; Schmid, Tobias; Blees, Johanna S; Colburn, Nancy H; Rajski, Scott R; Shen, Ben | Journal of natural products | 21870828 | 2011 Sep 23 |
| Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an ýý-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. | Li, Yanran; Chooi, Yit-Heng; Sheng, Yuewei; Valentine, Joan S; Tang, Yi | Journal of the American Chemical Society | 21866960 | 2011 Oct 5 |
| Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery. | Rolfe, Alan; Painter, Thomas O; Asad, Naeem; Hur, Moon Young; Jeon, Kyu Ok; Brzozowski, Marek; Klimberg, Sarra V; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Hanson, Paul R | ACS combinatorial science | 21866904 | 2011 Sep 12 |
| Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. | Wang, Rui; Ibanez, Glorymar; Islam, Kabirul; Zheng, Weihong; Blum, Gil; Sengelaub, Caitlin; Luo, Minkui | Molecular bioSystems | 21866297 | 2011 Nov |
| Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. | Fales, Andrew M; Yuan, Hsiangkuo; Vo-Dinh, Tuan | Langmuir : the ACS journal of surfaces and colloids | 21859159 | 2011 Oct 4 |
| N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. | Wencewicz, Timothy A; Yang, Baiyuan; Rudloff, James R; Oliver, Allen G; Miller, Marvin J | Journal of medicinal chemistry | 21859126 | 2011 Oct 13 |
| Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems. | Henrikson, Jon C; Ellis, Trevor K; King, Jarrod B; Cichewicz, Robert H | Journal of natural products | 21854017 | 2011 Sep 23 |
| Cross-pharmacology analysis of G protein-coupled receptors. | Brianso, Ferran; Carrascosa, Maria C; Oprea, Tudor I; Mestres, Jordi | Current topics in medicinal chemistry | 21851335 | 2011 |
| Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. | Montaser, Rana; Paul, Valerie J; Luesch, Hendrik | Phytochemistry | 21843895 | 2011 Nov |
| RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. | Martin, S E; Wu, Z-H; Gehlhaus, K; Jones, T L; Zhang, Y-W; Guha, R; Miyamoto, S; Pommier, Y; Caplen, N J | Current cancer drug targets | 21834757 | 2011 Oct |
| Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. | Tran, Hoang T; Zhang, Shuxing | Journal of chemical information and modeling | 21834588 | 2011 Sep 26 |
| Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds. | Granger, Brett A; Kaneda, Kyosuke; Martin, Stephen F | Organic letters | 21834504 | 2011 Sep 2 |
| Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1ýý inhibitors. | Huang, Wenwei; Huang, Ruili; Attene-Ramos, Matias S; Sakamuru, Srilatha; Englund, Erika E; Inglese, James; Austin, Christopher P; Xia, Menghang | Bioorganic & medicinal chemistry letters | 21831635 | 2011 Sep 15 |
| Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. | Knapp, John M; Fettinger, James C; Kurth, Mark J | Organic letters | 21827181 | 2011 Sep 2 |
| 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. | Kiselev, Evgeny; DeGuire, Sean; Morrell, Andrew; Agama, Keli; Dexheimer, Thomas S; Pommier, Yves; Cushman, Mark | Journal of medicinal chemistry | 21823606 | 2011 Sep 8 |
| Human pluripotent stem cells: the development of high-content screening strategies. | Sherman, Sean P; Alva, Jackelyn A; Thakore-Shah, Kaushali; Pyle, April D | Methods in molecular biology (Clifton, N.J.) | 21822883 | 2011 |
| Imaging mass spectrometry in microbiology. | Watrous, Jeramie D; Dorrestein, Pieter C | Nature reviews. Microbiology | 21822293 | 2011 Sep |
| Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | Xiao, Jingbo; Marugan, Juan J; Zheng, Wei; Titus, Steve; Southall, Noel; Cherry, Jonathan J; Evans, Matthew; Androphy, Elliot J; Austin, Christopher P | Journal of medicinal chemistry | 21819082 | 2011 Sep 22 |
| BDDCS applied to over 900 drugs. | Benet, Leslie Z; Broccatelli, Fabio; Oprea, Tudor I | The AAPS journal | 21818695 | 2011 Dec |
| Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. | Yuan, Jing; Cheng, Ken Chih-Chien; Johnson, Ronald L; Huang, Ruili; Pattaradilokrat, Sittiporn; Liu, Anna; Guha, Rajarshi; Fidock, David A; Inglese, James; Wellems, Thomas E; Austin, Christopher P; Su, Xin-zhuan | Science (New York, N.Y.) | 21817045 | 2011 Aug 5 |
| Metal-free chlorodeboronation of organotrifluoroborates. | Molander, Gary A; Cavalcanti, Livia N | The Journal of organic chemistry | 21812468 | 2011 Sep 2 |
| Phosphine-catalyzed annulations of azomethine imines: allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways. | Na, Risong; Jing, Chengfeng; Xu, Qihai; Jiang, Hui; Wu, Xi; Shi, Jiayan; Zhong, Jiangchun; Wang, Min; Benitez, Diego; Tkatchouk, Ekaterina; Goddard, William A; Guo, Hongchao; Kwon, Ohyun | Journal of the American Chemical Society | 21812448 | 2011 Aug 31 |
| Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. | Youngsaye, Willmen; Vincent, Benjamin; Hartland, Cathy L; Morgan, Barbara J; Buhrlage, Sara J; Johnston, Stephen; Bittker, Joshua A; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L; Muno | Bioorganic & medicinal chemistry letters | 21802942 | 2011 Sep 15 |
| High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. | Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick; Gray, Nathanael S | Chemistry & biology | 21802008 | 2011 Jul 29 |
| High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. | Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick | Chemistry & biology | 21802008 | 2011 Jul 29 |
| Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. | Correa, Ricardo G; Khan, Pasha M; Askari, Nadav; Zhai, Dayong; Gerlic, Motti; Brown, Brock; Magnuson, Gavin; Spreafico, Roberto; Albani, Salvatore; Sergienko, Eduard; Diaz, Paul W; Roth, Gregory P; Reed, John C | Chemistry & biology | 21802003 | 2011 Jul 29 |
| Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. | Miller, Melissa; Shi, Jie; Zhu, Yingmin; Kustov, Maksym; Tian, Jin-bin; Stevens, Amy; Wu, Meng; Xu, Jia; Long, Shunyou; Yang, Pu; Zholos, Alexander V; Salovich, James M; Weaver, C David; Hopkins, Corey R; Lindsley, Craig W; McManus, Owen; Li, Min; Zhu, Mi | The Journal of biological chemistry | 21795696 | 2011 Sep 23 |
| SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1Pýýý) receptor. | Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward | Bioorganic & medicinal chemistry letters | 21783362 | 2011 Sep 15 |
| Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. | Dennis, Megan K; Field, Angela S; Burai, Ritwik; Ramesh, Chinnasamy; Petrie, Whitney K; Bologa, Cristian G; Oprea, Tudor I; Yamaguchi, Yuri; Hayashi, Shin-Ichi; Sklar, Larry A; Hathaway, Helen J; Arterburn, Jeffrey B; Prossnitz, Eric R | The Journal of steroid biochemistry and molecular biology | 21782022 | 2011 Nov |
| Zeocin for selection of bleMX6 resistance in fission yeast. | Benko, Zsigmond; Zhao, Richard Y | BioTechniques | 21781055 | 2011 Jul |
| Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy. | Lo, Kai-Yin; Sun, Yung-Shin; Landry, James P; Zhu, Xiangdong; Deng, Wenbin | BioTechniques | 21781038 | 2011 Jun |
| Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A. | Leighty, Matthew W; Georg, Gunda I | ACS medicinal chemistry letters | 21779519 | 2011 Apr 14 |
| A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis. | Grimes, Kimberly D; Aldrich, Courtney C | Analytical biochemistry | 21771578 | 2011 Oct 15 |
| A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support. | Li, Yangmei; Giulianotti, Marc; Houghten, Richard A | Tetrahedron letters | 21765557 | 2010 Oct 27 |
| Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds. | Choi, Jonghoon; Kim, Kyobum; Kim, Taeho; Liu, Guanshu; Bar-Shir, Amnon; Hyeon, Taeghwan; McMahon, Michael T; Bulte, Jeff W M; Fisher, John P; Gilad, Assaf A | Journal of controlled release : official journal of the Controlled Release Society | 21763735 | 2011 Dec 10 |
| Sequencing cyclic peptides by multistage mass spectrometry. | Mohimani, Hosein; Yang, Yu-Liang; Liu, Wei-Ting; Hsieh, Pei-Wen; Dorrestein, Pieter C; Pevzner, Pavel A | Proteomics | 21751357 | 2011 Sep |
| Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. | Brown, Lauren E; Dai, Peng; Porco Jr, John A; Schaus, Scott E | Organic letters | 21749159 | 2011 Aug 19 |
| Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor. | Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; Sherrer, Eric S; McLean, Amanda B; Robins, Allan J; West, Lyndon M | Organic letters | 21749084 | 2011 Aug 5 |
| Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches. | Ekland, Eric H; Schneider, Jessica; Fidock, David A | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 21746861 | 2011 Oct |
| Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. | Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, | Journal of medicinal chemistry | 21739938 | 2011 Aug 11 |
| Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. | Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, David J; Holman, Theodore R | Journal of medicinal chemistry | 21739938 | 2011 Aug 11 |
| Phosphine-catalyzed [4+2] annulations of 2-alkylallenoates and olefins: synthesis of multisubstituted cyclohexenes. | Tran, Yang S; Martin, Tioga J; Kwon, Ohyun | Chemistry, an Asian journal | 21739609 | 2011 Aug 1 |
| First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp. | Wyche, Thomas P; Hou, Yanpeng; Braun, Doug; Cohen, Hannah C; Xiong, May P; Bugni, Tim S | The Journal of organic chemistry | 21736356 | 2011 Aug 19 |
| The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. | Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. | J Biol Chem | 21733839 | 2011 Sep 9 |
| Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. | Prigozhina, Natalie L; Heisel, Andrew; Wei, Ke; Noberini, Roberta; Hunter, Edward A; Calzolari, Diego; Seldeen, Jordan R; Pasquale, Elena B; Ruiz-Lozano, Pilar; Mercola, Mark; Price, Jeffrey H | Biology of the cell / under the auspices of the European Cell Biology Organization | 21732911 | 2011 Oct 1 |
| Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol. | Asad, Naeem; Hanson, Paul R; Long, Toby R; Rayabarapu, Dinesh K; Rolfe, Alan | Chemical communications (Cambridge, England) | 21727956 | 2011 Sep 7 |
| Receptor-based pharmacophore and pharmacophore key descriptors for virtual screening and QSAR modeling. | Dong, Xialan; Ebalunode, Jerry O; Yang, Sheng-Yong; Zheng, Weifan | Current computer-aided drug design | 21726192 | 2011 Sep 1 |
| Animal models of idiosyncratic drug-induced liver injury--current status. | Roth, Robert A; Ganey, Patricia E | Critical reviews in toxicology | 21726137 | 2011 Oct |
| Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. | Edlund, Anna; Loesgen, Sandra; Fenical, William; Jensen, Paul R | Applied and environmental microbiology | 21724881 | 2011 Sep |
| Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori. | Fei, Y Y; Schmidt, A; Bylund, G; Johansson, D X; Henriksson, S; Lebrilla, C; Solnick, J V; Boren, T; Zhu, X D | Analytical chemistry | 21721569 | 2011 Aug 15 |
| Synthesis and structure-activity evaluation of isatin-ýý-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein. | Hall, Matthew D; Brimacombe, Kyle R; Varonka, Matthew S; Pluchino, Kristen M; Monda, Julie K; Li, Jiayang; Walsh, Martin J; Boxer, Matthew B; Warren, Timothy H; Fales, Henry M; Gottesman, Michael M | Journal of medicinal chemistry | 21721528 | 2011 Aug 25 |
| Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling. | Cho, Chul-Hee; Jung, Dai-Il; Neuenswander, Benjamin; Larock, Richard C | ACS combinatorial science | 21721520 | 2011 Sep 12 |
| Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples. | Simons, Peter C; Young, Susan M; Carter, Mark B; Waller, Anna; Zhai, Dayong; Reed, John C; Edwards, Bruce S; Sklar, Larry A | Nature protocols | 21720309 | 2011 Jul |
| Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. | Gonzalez, David J; Haste, Nina M; Hollands, Andrew; Fleming, Tinya C; Hamby, Matthew; Pogliano, Kit; Nizet, Victor; Dorrestein, Pieter C | Microbiology (Reading, England) | 21719540 | 2011 Sep |
| Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. | Antczak, Christophe; Shum, David; Bassit, Bhramdeo; Frattini, Mark G; Li, Yueming; de Stanchina, Elisa; Scheinberg, David A; Djaballah, Hakim | Bioorganic & medicinal chemistry letters | 21719286 | 2011 Aug 1 |
| Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. | Walsh, Kevin B; Teijaro, John R; Wilker, Peter R; Jatzek, Anna; Fremgen, Daniel M; Das, Subash C; Watanabe, Tokiko; Hatta, Masato; Shinya, Kyoko; Suresh, Marulasiddappa; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B A | Proceedings of the National Academy of Sciences of the United States of America | 21715659 | 2011 Jul 19 |
| QSAR analysis of the toxicity of nitroaromatics in Tetrahymena pyriformis: structural factors and possible modes of action. | Artemenko, A G; Muratov, E N; Kuz'min, V E; Muratov, N N; Varlamova, E V; Kuz'mina, A V; Gorb, L G; Golius, A; Hill, F C; Leszczynski, J; Tropsha, A | SAR and QSAR in environmental research | 21714735 | 2011 Jul-Sep |
| Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. | Peterson, Katherine E; Cinelli, Maris A; Morrell, Andrew E; Mehta, Akhil; Dexheimer, Thomas S; Agama, Keli; Antony, Smitha; Pommier, Yves; Cushman, Mark | Journal of medicinal chemistry | 21710981 | 2011 Jul 28 |
| A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae. | Rasmussen, Lynn; White, E Lucile; Pathak, Ashish; Ayala, Julio C; Wang, Hongxia; Wu, Jian-He; Benitez, Jorge A; Silva, Anisia J | Antimicrobial agents and chemotherapy | 21709090 | 2011 Sep |
| Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry. | Kliman, Michal; May, Jody C; McLean, John A | Biochimica et biophysica acta | 21708282 | 2011 Nov |
| Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp. | Meickle, Theresa; Gunasekera, Sarath P; Liu, Yanxia; Luesch, Hendrik; Paul, Valerie J | Bioorganic & medicinal chemistry | 21705224 | 2011 Nov 15 |
| In situ kinase profiling reveals functionally relevant properties of native kinases. | Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Wu, Jiangyue; Brown, Heidi; Zhou, David; Zhang, Jianming; Jagannathan, Subadhra; Aban, Arwin; Okerberg, Eric; Herring, Chris; Nordin, Brian; Weissig, Helge; Yang, Qingkai; Lee, Jiing-Dwan; Gray, Nathanael S; Koz | Chemistry & biology | 21700206 | 2011 Jun 24 |
| Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. | Seyedsayamdost, Mohammad R; Traxler, Matthew F; Zheng, Shao-Liang; Kolter, Roberto; Clardy, Jon | Journal of the American Chemical Society | 21699219 | 2011 Aug 3 |
| A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. | Lone, Anna Mari; Bachovchin, Daniel A; Westwood, David B; Speers, Anna E; Spicer, Timothy P; Fernandez-Vega, Virneliz; Chase, Peter; Hodder, Peter S; Rosen, Hugh; Cravatt, Benjamin F; Saghatelian, Alan | Journal of the American Chemical Society | 21692504 | 2011 Aug 3 |
| Enhancing the rate of scaffold discovery with diversity-oriented prioritization. | Swamidass, S Joshua; Calhoun, Bradley T; Bittker, Joshua A; Bodycombe, Nicole E; Clemons, Paul A | Bioinformatics (Oxford, England) | 21685049 | 2011 Aug 15 |
| Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. | Gonzalez-Lopez, Marcos; Welsh, Kate; Finlay, Darren; Ardecky, Robert J; Ganji, Santhi Reddy; Su, Ying; Yuan, Hongbin; Teriete, Peter; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D P | Bioorganic & medicinal chemistry letters | 21680182 | 2011 Jul 15 |
| Up-regulation of A-type potassium currents protects neurons against cerebral ischemia. | Deng, Ping; Pang, Zhi-Ping; Lei, Zhigang; Shikano, Sojin; Xiong, Qiaojie; Harvey, Brandon K; London, Barry; Wang, Yun; Li, Min; Xu, Zao C | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism | 21673715 | 2011 Sep |
| Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. | Espinoza, Stefano; Salahpour, Ali; Masri, Bernard; Sotnikova, Tatyana D; Messa, Mirko; Barak, Larry S; Caron, Marc G; Gainetdinov, Raul R | Molecular pharmacology | 21670104 | 2011 Sep |
| Mutations in the BRCT binding site of BRCA1 result in hyper-recombination. | Dever, Seth M; Golding, Sarah E; Rosenberg, Elizabeth; Adams, Bret R; Idowu, Michael O; Quillin, John M; Valerie, Nicholas; Xu, Bo; Povirk, Lawrence F; Valerie, Kristoffer | Aging | 21666281 | 2011 May |
| Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones. | Kantevari, Srinivas; Yempala, Thirumal; Yogeeswari, Perumal; Sriram, Dharmarajan; Sridhar, Balasubramanian | Bioorganic & medicinal chemistry letters | 21665469 | 2011 Jul 15 |
| Reconstituting the key steps of the DNA double-strand break repair in vitro. | Rossi, Matthew J; Bugreev, Dmitry V; Mazina, Olga M; Mazin, Alexander V | Methods in molecular biology (Clifton, N.J.) | 21660707 | 2011 |
| Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities. | Agola, J O; Jim, P A; Ward, H H; Basuray, S; Wandinger-Ness, A | Clinical genetics | 21651512 | 2011 Oct |
| Synthesis of spiro-fused pyrazolidoylisoxazolines. | Guggenheim, Kathryn G; Butler, Jeffrey D; Painter, Phillip P; Lorsbach, Beth A; Tantillo, Dean J; Kurth, Mark J | The Journal of organic chemistry | 21650164 | 2011 Jul 15 |
| Design, synthesis, and diversification of 3,5-substituted enone library. | Khalaf, Juhienah; Estrella-Jimenez, Maria E; Shashack, Matthew J; Phatak, Sharangdhar S; Zhang, Shuxing; Gilbertson, Scott R | ACS combinatorial science | 21648460 | 2011 Jul 11 |
| 2D NMR-spectroscopic screening reveals polyketides in ladybugs. | Deyrup, Stephen T; Eckman, Laura E; McCarthy, Patrick H; Smedley, Scott R; Meinwald, Jerrold; Schroeder, Frank C | Proceedings of the National Academy of Sciences of the United States of America | 21646540 | 2011 Jun 14 |
| Two High Throughput Screen Assays for Measurement of TNF-ýý in THP-1 Cells. | Leister, Kristin P; Huang, Ruili; Goodwin, Bonnie L; Chen, Andrew; Austin, Christopher P; Xia, Menghang | Current chemical genomics | 21643507 | 2011 |
| Exploratory analysis of kinetic solubility measurements of a small molecule library. | Guha, Rajarshi; Dexheimer, Thomas S; Kestranek, Aimee N; Jadhav, Ajit; Chervenak, Andrew M; Ford, Michael G; Simeonov, Anton; Roth, Gregory P; Thomas, Craig J | Bioorganic & medicinal chemistry | 21640593 | 2011 Jul 1 |
| Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. | Bachovchin, Daniel A; Zuhl, Andrea M; Speers, Anna E; Wolfe, Monique R; Weerapana, Eranthie; Brown, Steven J; Rosen, Hugh; Cravatt, Benjamin F | Journal of medicinal chemistry | 21639134 | 2011 Jul 28 |
| RGD-conjugated human ferritin nanoparticles for imaging vascular inflammation and angiogenesis in experimental carotid and aortic disease. | Kitagawa, Toshiro; Kosuge, Hisanori; Uchida, Masaki; Dua, Monica M; Iida, Yasunori; Dalman, Ronald L; Douglas, Trevor; McConnell, Michael V | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging | 21638084 | 2012 Jun |
| Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. | Sooryakumar, Dhriti; Dexheimer, Thomas S; Teicher, Beverly A; Pommier, Yves | Molecular cancer therapeutics | 21636699 | 2011 Aug |
| The JAK2/STAT3 signaling pathway is required for growth of CD44ýýýCD24ýýý stem cell-like breast cancer cells in human tumors. | Marotta, Lauren L C; Almendro, Vanessa; Marusyk, Andriy; Shipitsin, Michail; Schemme, Janina; Walker, Sarah R; Bloushtain-Qimron, Noga; Kim, Jessica J; Choudhury, Sibgat A; Maruyama, Reo; Wu, Zhenhua; Gonen, Mithat; Mulvey, Laura A; Bessarabova, Marina O; | The Journal of clinical investigation | 21633165 | 2011 Jul |
| Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. | Shukla, Suneet; Skoumbourdis, Amanda P; Walsh, Martin J; Hartz, Anika M S; Fung, King Leung; Wu, Chung-Pu; Gottesman, Michael M; Bauer, Bjorn; Thomas, Craig J; Ambudkar, Suresh V | Molecular pharmaceutics | 21630681 | 2011 Aug 1 |
| Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. | Wythe, Joshua D; Jurynec, Michael J; Urness, Lisa D; Jones, Christopher A; Sabeh, M Khaled; Werdich, Andreas A; Sato, Mariko; Yost, H Joseph; Grunwald, David J; Macrae, Calum A; Li, Dean Y | Disease models & mechanisms | 21628396 | 2011 Sep-Oct |
| Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization. | Pokorski, Jonathan K; Breitenkamp, Kurt; Liepold, Lars O; Qazi, Shefah; Finn, M G | Journal of the American Chemical Society | 21627118 | 2011 Jun 22 |
| Fluorescent proton sensors based on energy transfer. | Thivierge, Cliferson; Han, Junyan; Jenkins, Roxanne M; Burgess, Kevin | The Journal of organic chemistry | 21618970 | 2011 Jul 1 |
| Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. | Reyes, Maribel; Benet, Leslie Z | Journal of pharmaceutical sciences | 21618544 | 2011 Sep |
| Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. | Wang, Hao-Ran; Wu, Meng; Yu, Haibo; Long, Shunyou; Stevens, Amy; Engers, Darren W; Sackin, Henry; Daniels, J Scott; Dawson, Eric S; Hopkins, Corey R; Lindsley, Craig W; Li, Min; McManus, Owen B | ACS chemical biology | 21615117 | 2011 Aug 19 |
| Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. | Carr, Gavin; Seyedsayamdost, Mohammad R; Chandler, Josephine R; Greenberg, E Peter; Clardy, Jon | Organic letters | 21615115 | 2011 Jun 17 |
| Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis. | Forseth, Ry R; Fox, Ellen M; Chung, DaWoon; Howlett, Barbara J; Keller, Nancy P; Schroeder, Frank C | Journal of the American Chemical Society | 21612254 | 2011 Jun 29 |
| The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles. | Conrad, Wayne E; Fukazawa, Ryo; Haddadin, Makhluf J; Kurth, Mark J | Organic letters | 21612219 | 2011 Jun 17 |
| Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument. | Baillargeon, Pierre; Scampavia, Louis; Einsteder, Ross; Hodder, Peter | Journal of laboratory automation | 21609702 | 2011 Jun |
| Development of p97 AAA ATPase inhibitors. | Chou, Tsui-Fen; Deshaies, Raymond J | Autophagy | 21606684 | 2011 Sep |
| Structural determinants of the alpha2 adrenoceptor subtype selectivity. | Ostopovici-Halip, Liliana; Curpan, Ramona; Mracec, Maria; Bologa, Cristian G | Journal of molecular graphics & modelling | 21602069 | 2011 Aug |
| Multicomponent assembly and diversification of novel heterocyclic scaffolds derived from 2-arylpiperidines. | Hardy, Simon; Martin, Stephen F | Organic letters | 21598984 | 2011 Jun 17 |
| Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. | Xia, Menghang; Guo, Vicky; Huang, Ruili; Shahane, Sampada A; Austin, Christopher P; Nirenberg, Marshall; Sharma, Shail K | Cellular and molecular neurobiology | 21598037 | 2011 Aug |
| Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. | Xu, Cheng-Ran; Cole, Philip A; Meyers, David J; Kormish, Jay; Dent, Sharon; Zaret, Kenneth S | Science (New York, N.Y.) | 21596989 | 2011 May 20 |
| Bacterial symbionts and natural products. | Crawford, Jason M; Clardy, Jon | Chemical communications (Cambridge, England) | 21594283 | 2011 Jul 21 |
| Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. | Haynes, Stuart W; Ames, Brian D; Gao, Xue; Tang, Yi; Walsh, Christopher T | Biochemistry | 21591693 | 2011 Jun 28 |
| Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. | Yang, Yu-Liang; Xu, Yuquan; Kersten, Roland D; Liu, Wei-Ting; Meehan, Michael J; Moore, Bradley S; Bandeira, Nuno; Dorrestein, Pieter C | Angewandte Chemie (International ed. in English) | 21574228 | 2011 Jun 20 |
| Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. | Guerrero, Miguel; Urbano, Mariangela; Velaparthi, Subash; Zhao, Jian; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward | Bioorganic & medicinal chemistry letters | 21570287 | 2011 Jun 15 |
| Synthesis, activity, and structural analysis of novel ýý-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. | Chung, Suhman; Himmel, Daniel M; Jiang, Jian-Kang; Wojtak, Krzysztof; Bauman, Joseph D; Rausch, Jason W; Wilson, Jennifer A; Beutler, John A; Thomas, Craig J; Arnold, Eddy; Le Grice, Stuart F J | Journal of medicinal chemistry | 21568335 | 2011 Jul 14 |
| Characterizing the diversity and biological relevance of the MLPCN assay manifold and screening set. | Zhang, Jintao; Lushington, Gerald H; Huan, Jun | Journal of chemical information and modeling | 21568288 | 2011 Jun 27 |
| High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry. | Curpan, Ramona F; Simons, Peter C; Zhai, Dayong; Young, Susan M; Carter, Mark B; Bologa, Cristian G; Oprea, Tudor I; Satterthwait, Arnold C; Reed, John C; Edwards, Bruce S; Sklar, Larry A | Assay and drug development technologies | 21561376 | 2011 Oct |
| Solving the puzzle of metastasis: the evolution of cell migration in neoplasms. | Chen, Jun; Sprouffske, Kathleen; Huang, Qihong; Maley, Carlo C | PloS one | 21556134 | 2011 |
| Magnetic resonance imaging of cells in experimental disease models. | Muja, Naser; Bulte, Jeff W M | Progress in nuclear magnetic resonance spectroscopy | 21552511 | 2009 Jul |
| Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and ýý-amino alcohols. | Fan, Yi Chiao; Kwon, Ohyun | Molecules (Basel, Switzerland) | 21546881 | 2011 |
| Proteostasis: a new therapeutic paradigm for pulmonary disease. | Bouchecareilh, Marion; Balch, William E | Proceedings of the American Thoracic Society | 21543800 | 2011 May |
| Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. | Huang, Ruili; Xia, Menghang; Cho, Ming-Hsuang; Sakamuru, Srilatha; Shinn, Paul; Houck, Keith A; Dix, David J; Judson, Richard S; Witt, Kristine L; Kavlock, Robert J; Tice, Raymond R; Austin, Christopher P | Environmental health perspectives | 21543282 | 2011 Aug |
| Agonist-directed desensitization of the ýý2-adrenergic receptor. | Goral, Vasiliy; Jin, Yan; Sun, Haiyan; Ferrie, Ann M; Wu, Qi; Fang, Ye | PloS one | 21541288 | 2011 |
| Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals. | Wurst, Jacqueline M; Liu, Guodong; Tan, Derek S | Journal of the American Chemical Society | 21539313 | 2011 May 25 |
| Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. | Dahl, Russell; Bravo, Yalda; Sharma, Vandana; Ichikawa, Mie; Dhanya, Raveendra-Panickar; Hedrick, Michael; Brown, Brock; Rascon, Justin; Vicchiarelli, Michael; Mangravita-Novo, Arianna; Yang, Li; Stonich, Derek; Su, Ying; Smith, Layton H; Sergienko, Eduar | Journal of medicinal chemistry | 21539312 | 2011 May 26 |
| Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. | Yamamoto, Kimiyo N; Hirota, Kouji; Kono, Koichi; Takeda, Shunichi; Sakamuru, Srilatha; Xia, Menghang; Huang, Ruili; Austin, Christopher P; Witt, Kristine L; Tice, Raymond R | Environmental and molecular mutagenesis | 21538559 | 2011 Aug |
| High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. | Li, Angela Ying-Jian; Lin, Her Helen; Kuo, Ching-Ying; Shih, Hsiu-Ming; Wang, Clay Chia Chun; Yen, Yun; Ann, David Kong | Molecular and cellular biology | 21536653 | 2011 Jul |
| Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. | Kotsikorou, Evangelia; Madrigal, Karla E; Hurst, Dow P; Sharir, Haleli; Lynch, Diane L; Heynen-Genel, Susanne; Milan, Loribelle B; Chung, Thomas D Y; Seltzman, Herbert H; Bai, Yushi; Caron, Marc G; Barak, Larry; Abood, Mary E; Reggio, Patricia H | Biochemistry | 21534610 | 2011 Jun 28 |
| Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. | Grindberg, Rashel V; Ishoey, Thomas; Brinza, Dumitru; Esquenazi, Eduardo; Coates, R Cameron; Liu, Wei-ting; Gerwick, Lena; Dorrestein, Pieter C; Pevzner, Pavel; Lasken, Roger; Gerwick, William H | PloS one | 21533272 | 2011 |
| RS-predictor: a new tool for predicting sites of cytochrome P450-mediated metabolism applied to CYP 3A4. | Zaretzki, Jed; Bergeron, Charles; Rydberg, Patrik; Huang, Tao-wei; Bennett, Kristin P; Breneman, Curt M | Journal of chemical information and modeling | 21528931 | 2011 Jul 25 |
| Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data. | Chalmers, Michael J; Pascal, Bruce D; Willis, Scooter; Zhang, Jun; Iturria, Stephen J; Dodge, Jeffery A; Griffin, Patrick R | International journal of mass spectrometry | 21528013 | 2011 Apr 30 |
| The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. | Huang, Ruili; Southall, Noel; Wang, Yuhong; Yasgar, Adam; Shinn, Paul; Jadhav, Ajit; Nguyen, Dac-Trung; Austin, Christopher P | Science translational medicine | 21525397 | 2011 Apr 27 |
| Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. | Boutin, Alisa; Allen, Michael D; Geras-Raaka, Elizabeth; Huang, Wenwei; Neumann, Susanne; Gershengorn, Marvin C | Molecular pharmacology | 21525174 | 2011 Aug |
| Integrating virtual screening and combinatorial chemistry for accelerated drug discovery. | Lopez-Vallejo, Fabian; Caulfield, Thomas; Martinez-Mayorga, Karina; Giulianotti, Marc A; Nefzi, Adel; Houghten, Richard A; Medina-Franco, Jose L | Combinatorial chemistry & high throughput screening | 21521151 | 2011 Jul |
| Active-site-directed chemical tools for profiling mitochondrial Lon protease. | Fishovitz, Jennifer; Li, Min; Frase, Hilary; Hudak, Jason; Craig, Sandra; Ko, Kristin; Berdis, Anthony J; Suzuki, Carolyn K; Lee, Irene | ACS chemical biology | 21520912 | 2011 Aug 19 |
| The nitrosocarbonyl hetero-Diels-Alder reaction as a useful tool for organic syntheses. | Bodnar, Brian S; Miller, Marvin J | Angewandte Chemie (International ed. in English) | 21520360 | 2011 Jun 14 |
| Magnetomotive molecular nanoprobes. | John, Renu; Boppart, Stephen A | Current medicinal chemistry | 21517766 | 2011 |
| Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction. | Leclair, Christopher A; Boxer, Matthew B; Thomas, Craig J; Maloney, David J | Tetrahedron letters | 21516235 | 2010 Dec 29 |
| Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. | Chigaev, Alexandre; Smagley, Yelena; Zhang, Yinan; Waller, Anna; Haynes, Mark K; Amit, Or; Wang, Wei; Larson, Richard S; Sklar, Larry A | The Journal of biological chemistry | 21515675 | 2011 Jun 10 |
| Amphiregulin exosomes increase cancer cell invasion. | Higginbotham, James N; Demory Beckler, Michelle; Gephart, Jonathan D; Franklin, Jeffrey L; Bogatcheva, Galina; Kremers, Gert-Jan; Piston, David W; Ayers, Gregory D; McConnell, Russell E; Tyska, Matthew J; Coffey, Robert J | Current biology : CB | 21514161 | 2011 May 10 |
| Facile and unified approach to skeletally diverse, privileged scaffolds. | Sahn, James J; Su, Justin Y; Martin, Stephen F | Organic letters | 21513290 | 2011 May 20 |
| Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. | Cencic, Regina; Desforges, Marc; Hall, David R; Kozakov, Dima; Du, Yuhong; Min, Jaeki; Dingledine, Raymond; Fu, Haian; Vajda, Sandor; Talbot, Pierre J; Pelletier, Jerry | Journal of virology | 21507972 | 2011 Jul |
| Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids. | Bobkova, Ekaterina V; Liu, Wallace H; Colayco, Sharon; Rascon, Justin; Vasile, Stefan; Gasior, Carlton; Critton, David A; Chan, Xochella; Dahl, Russell; Su, Ying; Sergienko, Eduard; Chung, Thomas D Y; Mustelin, Tomas; Page, Rebecca; Tautz, Lutz | ACS medicinal chemistry letters | 21503265 | 2011 Feb |
| Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. | Huryn, Donna M; Brodsky, Jeffrey L; Brummond, Kay M; Chambers, Peter G; Eyer, Benjamin; Ireland, Alex W; Kawasumi, Masaoki; Laporte, Matthew G; Lloyd, Kayla; Manteau, Baptiste; Nghiem, Paul; Quade, Bettina; Seguin, Sandlin P; Wipf, Peter | Proceedings of the National Academy of Sciences of the United States of America | 21502524 | 2011 Apr 26 |
| Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. | Solt, Laura A; Kumar, Naresh; Nuhant, Philippe; Wang, Yongjun; Lauer, Janelle L; Liu, Jin; Istrate, Monica A; Kamenecka, Theodore M; Roush, William R; Vidovic, Dusica; Schurer, Stephan C; Xu, Jihong; Wagoner, Gail; Drew, Paul D; Griffin, Patrick R; Burris | Nature | 21499262 | 2011 Apr 28 |
| Discovery of new antimalarial chemotypes through chemical methodology and library development. | Brown, Lauren E; Chih-Chien Cheng, Ken; Wei, Wan-Guo; Yuan, Pingwei; Dai, Peng; Trilles, Richard; Ni, Feng; Yuan, Jing; MacArthur, Ryan; Guha, Rajarshi; Johnson, Ronald L; Su, Xin-zhuan; Dominguez, Melissa M; Snyder, John K; Beeler, Aaron B; Schaus, Scott E; Inglese, James; Porco Jr, John A | Proceedings of the National Academy of Sciences of the United States of America | 21498685 | 2011 Apr 26 |
| Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells. | Zhou, Kejin; Wang, Yiguang; Huang, Xiaonan; Luby-Phelps, Katherine; Sumer, Baran D; Gao, Jinming | Angewandte Chemie (International ed. in English) | 21495146 | 2011 Jun 27 |
| Noncanonical TGFýý signaling contributes to aortic aneurysm progression in Marfan syndrome mice. | Holm, Tammy M; Habashi, Jennifer P; Doyle, Jefferson J; Bedja, Djahida; Chen, YiChun; van Erp, Christel; Lindsay, Mark E; Kim, David; Schoenhoff, Florian; Cohn, Ronald D; Loeys, Bart L; Thomas, Craig J; Patnaik, Samarjit; Marugan, Juan J; Judge, Daniel P; Dietz, Harry C | Science (New York, N.Y.) | 21493862 | 2011 Apr 15 |
| Phosphine-catalyzed ýý'-umpolung addition of nucleophiles to activated ýý-alkyl allenes. | Martin, Tioga J; Vakhshori, Venus G; Tran, Yang S; Kwon, Ohyun | Organic letters | 21491870 | 2011 May 20 |
| Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. | Mevers, Emily; Liu, Wei-Ting; Engene, Niclas; Mohimani, Hosein; Byrum, Tara; Pevzner, Pavel A; Dorrestein, Pieter C; Spadafora, Carmenza; Gerwick, William H | Journal of natural products | 21488639 | 2011 May 27 |
| Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. | Fiamegos, Yiannis C; Kastritis, Panagiotis L; Exarchou, Vassiliki; Han, Haley; Bonvin, Alexandre M J J; Vervoort, Jacques; Lewis, Kim; Hamblin, Michael R; Tegos, George P | PloS one | 21483731 | 2011 |
| Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections. | Clemons, Paul A; Wilson, J Anthony; Dancik, Vlado; Muller, Sandrine; Carrinski, Hyman A; Wagner, Bridget K; Koehler, Angela N; Schreiber, Stuart L | Proceedings of the National Academy of Sciences of the United States of America | 21482810 | 2011 Apr 26 |
| A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. | Johnson, Ronald L; Hwang, Jong Yeon; Arnold, Leggy A; Huang, Ruili; Wichterman, Jennifer; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Guy, R Kiplin; Huang, Wenwei | Journal of biomolecular screening | 21482722 | 2011 Jul |
| An improved cerulean fluorescent protein with enhanced brightness and reduced reversible photoswitching. | Markwardt, Michele L; Kremers, Gert-Jan; Kraft, Catherine A; Ray, Krishanu; Cranfill, Paula J C; Wilson, Korey A; Day, Richard N; Wachter, Rebekka M; Davidson, Michael W; Rizzo, Mark A | PloS one | 21479270 | 2011 |
| Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy. | Gramling, S; Rogers, C; Liu, G; Reisman, D | Oncogene | 21478905 | 2011 Jul 21 |
| DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. | Zhang, Jun; Chalmers, Michael J; Stayrook, Keith R; Burris, Lorri L; Wang, Yongjun; Busby, Scott A; Pascal, Bruce D; Garcia-Ordonez, Ruben D; Bruning, John B; Istrate, Monica A; Kojetin, Douglas J; Dodge, Jeffrey A; Burris, Thomas P; Griffin, Patrick R | Nature structural & molecular biology | 21478866 | 2011 May |
| Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing. | Kaya, Mehmet; Feingold, Steven; Hettiarachchi, Kanaka; Lee, Abraham P; Dayton, Paul A | Bubble science engineering and technology | 21475641 | 2010 Dec |
| Microbial efflux pump inhibition: tactics and strategies. | Tegos, George P; Haynes, Mark; Strouse, J Jacob; Khan, Mohiuddin Md T; Bologa, Cristian G; Oprea, Tudor I; Sklar, Larry A | Current pharmaceutical design | 21470111 | 2011 |
| Importazole, a small molecule inhibitor of the transport receptor importin-ýý. | Soderholm, Jonathan F; Bird, Stephen L; Kalab, Petr; Sampathkumar, Yasaswini; Hasegawa, Keisuke; Uehara-Bingen, Michael; Weis, Karsten; Heald, Rebecca | ACS chemical biology | 21469738 | 2011 Jul 15 |
| A facile surfactant critical micelle concentration determination. | Cai, Lifeng; Gochin, Miriam; Liu, Keliang | Chemical communications (Cambridge, England) | 21468398 | 2011 May 21 |
| High Throughput Synthesis of 2,3,6-Trisubstituted-5,6-Dihydroimidazo[2,1-b]thiazole Derivatives. | Li, Yangmei; Giulianotti, Marc; Houghten, Richard A | Tetrahedron letters | 21461055 | 2011 Feb 9 |
| Three-component synthesis of cyclic enaminones via ketene cyclization. | Seki, Hajime; Georg, Gunda I | Organic letters | 21456588 | 2011 May 6 |
| Energy transfer cassettes in silica nanoparticles target intracellular organelles. | Jose, Jiney; Loudet, Aurore; Ueno, Yuichiro; Wu, Liangxing; Chen, Hsiang-Yun; Son, Dong Hee; Barhoumi, Rola; Burghardt, Robert; Burgess, Kevin | Organic & biomolecular chemistry | 21455504 | 2011 May 21 |
| Assay of the multiple energy-producing pathways of mammalian cells. | Bochner, Barry R; Siri, Mark; Huang, Richard H; Noble, Shawn; Lei, Xiang-He; Clemons, Paul A; Wagner, Bridget K | PloS one | 21455318 | 2011 |
| Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines. | Pepe, Antonella; Pamment, Michael; Georg, Gunda I; Malhotra, Sanjay V | The Journal of organic chemistry | 21452823 | 2011 May 6 |
| Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. | Moura-Letts, Gustavo; Diblasi, Christine M; Bauer, Renato A; Tan, Derek S | Proceedings of the National Academy of Sciences of the United States of America | 21451137 | 2011 Apr 26 |
| Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). | Rosenthal, Andrew S; Tanega, Cordelle; Shen, Min; Mott, Bryan T; Bougie, James M; Nguyen, Dac-Trung; Misteli, Tom; Auld, Douglas S; Maloney, David J; Thomas, Craig J | Bioorganic & medicinal chemistry letters | 21450467 | 2011 May 15 |
| Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. | Salvador, Lilibeth A; Biggs, Jason S; Paul, Valerie J; Luesch, Hendrik | Journal of natural products | 21446699 | 2011 May 27 |
| Actions of a picomolar short-acting S1Pýýý agonist in S1Pýýý-eGFP knock-in mice. | Cahalan, Stuart M; Gonzalez-Cabrera, Pedro J; Sarkisyan, Gor; Nguyen, Nhan; Schaeffer, Marie-Therese; Huang, Liming; Yeager, Adam; Clemons, Bryan; Scott, Fiona; Rosen, Hugh | Nature chemical biology | 21445057 | 2011 May |
| Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. | Chu, Wenhua; Rothfuss, Justin; Zhou, Dong; Mach, Robert H | Bioorganic & medicinal chemistry letters | 21441025 | 2011 Apr 15 |
| Highly substituted lactone/ester-containing furan library by the palladium-catalyzed carbonylation of hydroxyl-substituted 3-iodofurans. | Cho, Chul-Hee; Larock, Richard C | ACS combinatorial science | 21434604 | 2011 May 9 |
| Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria. | Chlipala, George; Mo, Shunyan; Carcache de Blanco, Esperanza J; Ito, Aiko; Bazarek, Stanley; Orjala, Jimmy | Pharmaceutical biology | 21430788 | 2009 Jan |
| The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. | Seyedsayamdost, Mohammad R; Case, Rebecca J; Kolter, Roberto; Clardy, Jon | Nature chemistry | 21430694 | 2011 Apr |
| Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. | Huang, Fei; Motlekar, Nuzhat A; Burgwin, Chelsea M; Napper, Andrew D; Diamond, Scott L; Mazin, Alexander V | ACS chemical biology | 21428443 | 2011 Jun 17 |
| Chemistry and biology of macrolide antiparasitic agents. | Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R; Boothroyd, John C; Khosla, Chaitan | Journal of medicinal chemistry | 21428405 | 2011 Apr 28 |
| Functional model of metabolite gating by human voltage-dependent anion channel 2. | Bauer, Andras J; Gieschler, Simone; Lemberg, Kathryn M; McDermott, Ann E; Stockwell, Brent R | Biochemistry | 21425834 | 2011 May 3 |
| Hybrid top-down and bottom-up fabrication approach for wafer-scale plasmonic nanoplatforms. | Dhawan, Anuj; Du, Yan; Batchelor, Dale; Wang, Hsin-Neng; Leonard, Donovon; Misra, Veena; Ozturk, Mehmet; Gerhold, Michael D; Vo-Dinh, Tuan | Small (Weinheim an der Bergstrasse, Germany) | 21425456 | 2011 Mar 21 |
| Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines. | Markina, Nataliya A; Mancuso, Raffaella; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C | ACS combinatorial science | 21410207 | 2011 May 9 |
| Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. | Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Ledeboer, Nathan; Huang, Sheng-Xiong; Rajski, Scott R; Kron, Michael; Shen, Ben | Organic letters | 21405052 | 2011 Apr 15 |
| Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. | Bachovchin, Daniel A; Mohr, Justin T; Speers, Anna E; Wang, Chu; Berlin, Jacob M; Spicer, Timothy P; Fernandez-Vega, Virneliz; Chase, Peter; Hodder, Peter S; Schurer, Stephan C; Nomura, Daniel K; Rosen, Hugh; Fu, Gregory C; Cravatt, Benjamin F | Proceedings of the National Academy of Sciences of the United States of America | 21398589 | 2011 Apr 26 |
| A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions. | Du, Yuhong; Nikolovska-Coleska, Zaneta; Qui, Min; Li, Lian; Lewis, Iestyn; Dingledine, Raymond; Stuckey, Jeanne A; Krajewski, Krzysztof; Roller, Peter P; Wang, Shaomeng; Fu, Haian | Assay and drug development technologies | 21395401 | 2011 Aug |
| One-pot synthesis of 2-amino-indole-3-carboxamide and analogous. | Wang, Kan; Herdtweck, Eberhardt; Domling, Alexander | ACS combinatorial science | 21395342 | 2011 Mar 14 |
| Deep UV nano-microstructuring of substrates for surface plasmon resonance imaging. | Dhawan, A; Duval, A; Nakkach, M; Barbillon, G; Moreau, J; Canva, M; Vo-Dinh, T | Nanotechnology | 21393822 | 2011 Apr 22 |
| Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. | LaFleur, Michael D; Lucumi, Edinson; Napper, Andrew D; Diamond, Scott L; Lewis, Kim | The Journal of antimicrobial chemotherapy | 21393183 | 2011 Apr |
| Protein cage nanoparticles bearing the LyP-1 peptide for enhanced imaging of macrophage-rich vascular lesions. | Uchida, Masaki; Kosuge, Hisanori; Terashima, Masahiro; Willits, Deborah A; Liepold, Lars O; Young, Mark J; McConnell, Michael V; Douglas, Trevor | ACS nano | 21391720 | 2011 Apr 26 |
| Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines. | Chavez, Kathryn J; Feng, Xiaohong; Flanders, James A; Rodriguez, Eloy; Schroeder, Frank C | Journal of natural products | 21391655 | 2011 May 27 |
| AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. | Pan, Jen Q; Lewis, Michael C; Ketterman, Josh K; Clore, Elizabeth L; Riley, Misha; Richards, Keenan R; Berry-Scott, Erin; Liu, Xiulin; Wagner, Florence F; Holson, Edward B; Neve, Rachael L; Biechele, Travis L; Moon, Randall T; Scolnick, Edward M; Petryshe | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology | 21389981 | 2011 Jun |
| Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents. | Evdokimov, Nikolai M; Van Slambrouck, Severine; Heffeter, Petra; Tu, Lee; Le Calve, Benjamin; Lamoral-Theys, Delphine; Hooten, Carla J; Uglinskii, Pavel Y; Rogelj, Snezna; Kiss, Robert; Steelant, Wim F A; Berger, Walter; Yang, Jeremy J; Bologa, Cristian G | Journal of medicinal chemistry | 21388138 | 2011 Apr 14 |
| A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines. | Qiao, Kangjian; Zhou, Hui; Xu, Wei; Zhang, Wenjun; Garg, Neil; Tang, Yi | Organic letters | 21384820 | 2011 Apr 1 |
| Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). | Ghoreschi, Kamran; Jesson, Michael I; Li, Xiong; Lee, Jamie L; Ghosh, Sarbani; Alsup, Jason W; Warner, James D; Tanaka, Masao; Steward-Tharp, Scott M; Gadina, Massimo; Thomas, Craig J; Minnerly, John C; Storer, Chad E; LaBranche, Timothy P; Radi, Zaher A; Dowty, Martin E; Head, Richard D; Meyer, Debra M; Kishore, Nandini; O'Shea, John J | Journal of immunology (Baltimore, Md. : 1950) | 21383241 | 2011 Apr 1 |
| Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. | Chou, Tsui-Fen; Brown, Steve J; Minond, Dmitriy; Nordin, Brian E; Li, Kelin; Jones, Amanda C; Chase, Peter; Porubsky, Patrick R; Stoltz, Brian M; Schoenen, Frank J; Patricelli, Matthew P; Hodder, Peter; Rosen, Hugh; Deshaies, Raymond J | Proceedings of the National Academy of Sciences of the United States of America | 21383145 | 2011 Mar 22 |
| Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity. | Cruz, Daniel; Wang, Zhiming; Kibbie, Jon; Modlin, Robert; Kwon, Ohyun | Proceedings of the National Academy of Sciences of the United States of America | 21383121 | 2011 Apr 26 |
| Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors. | Busby, Scott A; Kumar, Naresh; Kuruvilla, Dana S; Istrate, Monica A; Conkright, Juliana J; Wang, Yongjun; Kamenecka, Theodore M; Cameron, Michael D; Roush, William R; Burris, Thomas P; Griffin, Patrick R | ACS chemical biology | 21381756 | 2011 Jun 17 |
| Marinobufagenin levels in preeclamptic patients: a preliminary report. | Agunanne, Enoch; Horvat, Darijana; Harrison, Recherael; Uddin, M Nasir; Jones, Richard; Kuehl, Thomas J; Ghanem, Daad Abi; Berghman, Luc R; Lai, Xinzhong; Li, Jing; Romo, Daniel; Puschett, Jules B | American journal of perinatology | 21380994 | 2011 Aug |
| Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. | Deng, Xianming; Dzamko, Nicolas; Prescott, Alan; Davies, Paul; Liu, Qingsong; Yang, Qingkai; Lee, Jiing-Dwan; Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Alessi, Dario R; Gray, Nathanael S | Nature chemical biology | 21378983 | 2011 Apr |
| The binding of fluorophores to proteins depends on the cellular environment. | Kim, Yun Kyung; Lee, Jun-Seok; Bi, Xuezhi; Ha, Hyung-Ho; Ng, Shin Hui; Ahn, Young-hoon; Lee, Jae-Jung; Wagner, Bridget K; Clemons, Paul A; Chang, Young-Tae | Angewandte Chemie (International ed. in English) | 21370369 | 2011 Mar 14 |
| Discovering small-molecule estrogen receptor ýý/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency. | Sun, Aiming; Moore, Terry W; Gunther, Jillian R; Kim, Mi-Sun; Rhoden, Eric; Du, Yuhong; Fu, Haian; Snyder, James P; Katzenellenbogen, John A | ChemMedChem | 21365764 | 2011 Apr 4 |
| The effect of inhaled gases on ultrasound contrast agent longevity in vivo. | Itani, Malak; Mattrey, Robert F | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging | 21365328 | 2012 Feb |
| Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. | Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon; Currie, Cameron R | PloS one | 21364940 | 2011 |
| Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. | Xia, Menghang; Shahane, Sampada A; Huang, Ruili; Titus, Steven A; Shum, Enoch; Zhao, Yong; Southall, Noel; Zheng, Wei; Witt, Kristine L; Tice, Raymond R; Austin, Christopher P | Toxicology and applied pharmacology | 21362439 | 2011 May 1 |
| Equilibrium between a vinylogous ylide and a phosphonium dienolate zwitterion: vinylogous Wittig olefination versus vinylogous aldol-type reaction. | Khong, San N; Tran, Yang S; Kwon, Ohyun | Tetrahedron | 21359169 | 2010 Jun |
| Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production. | Siddiquee, Khandaker; Hampton, Jessica; Khan, Susan; Zadory, Dan; Gleaves, Linda; Vaughan, Douglas E; Smith, Layton H | Journal of hypertension | 21358420 | 2011 Apr |
| RNA localization in bacteria. | Keiler, Kenneth C | Current opinion in microbiology | 21354362 | 2011 Apr |
| Photoscattering effect in supercontinuum-generating photonic crystal fiber. | Tu, H; Marks, D L; Jiang, Z; Boppart, S A | Applied physics letters | 21350681 | 2008 Feb 11 |
| Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. | Chou, Tsui-Fen; Deshaies, Raymond J | The Journal of biological chemistry | 21343295 | 2011 May 13 |
| A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields. | Broccatelli, Fabio; Carosati, Emanuele; Neri, Annalisa; Frosini, Maria; Goracci, Laura; Oprea, Tudor I; Cruciani, Gabriele | Journal of medicinal chemistry | 21341745 | 2011 Mar 24 |
| Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. | Gunasekera, Sarath P; Owle, Chivas S; Montaser, Rana; Luesch, Hendrik; Paul, Valerie J | Journal of natural products | 21341718 | 2011 Apr 25 |
| Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. | Stanford, Stephanie M; Krishnamurthy, Divya; Falk, Matthew D; Messina, Rossella; Debnath, Bikash; Li, Sheng; Liu, Tong; Kazemi, Roza; Dahl, Russell; He, Yantao; Yu, Xiao; Chan, Andrew C; Zhang, Zhong-Yin; Barrios, Amy M; Woods Jr, Virgil L; Neamati, Nouri | Journal of medicinal chemistry | 21341673 | 2011 Mar 24 |
| The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. | Popowicz, Grzegorz M; Domling, Alexander; Holak, Tad A | Angewandte Chemie (International ed. in English) | 21341346 | 2011 Mar 14 |
| Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluýýý. | Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R | ACS combinatorial science | 21338051 | 2011 Mar 14 |
| A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. | Li, Hui-Fang; Keeton, Adam; Vitolo, Michele; Maddox, Clinton; Rasmussen, Lynn; Hobrath, Judith; White, E Lucille; Park, Ben Ho; Piazza, Gary A; Kim, Jung-Sik; Waldman, Todd | Journal of biomolecular screening | 21335596 | 2011 Apr |
| Biotin tethered homotryptamine derivatives: high affinity probes of the human serotonin transporter (hSERT). | Tomlinson, Ian D; Iwamoto, Hideki; Blakely, Randy D; Rosenthal, Sandra J | Bioorganic & medicinal chemistry letters | 21334895 | 2011 Mar 15 |
| Large-scale analysis of UPR-mediated apoptosis in human cells. | Fribley, Andrew M; Miller, Justin R; Reist, Tyler E; Callaghan, Michael U; Kaufman, Randal J | Methods in enzymology | 21329794 | 2011 |
| Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. | Chalmers, Michael J; Busby, Scott A; Pascal, Bruce D; West, Graham M; Griffin, Patrick R | Expert review of proteomics | 21329427 | 2011 Feb |
| Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. | Liu, Qingsong; Wang, Jinhua; Kang, Seong A; Thoreen, Carson C; Hur, Wooyoung; Ahmed, Tausif; Sabatini, David M; Gray, Nathanael S | Journal of medicinal chemistry | 21322566 | 2011 Mar 10 |
| The evolving field of imaging mass spectrometry and its impact on future biological research. | Watrous, Jeramie D; Alexandrov, Theodore; Dorrestein, Pieter C | Journal of mass spectrometry : JMS | 21322093 | 2011 Feb |
| Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. | Hwang, Jong Yeon; Huang, Wenwei; Arnold, Leggy A; Huang, Ruili; Attia, Ramy R; Connelly, Michele; Wichterman, Jennifer; Zhu, Fangyi; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Johnson, Ronald L; Guy, R Kiplin | The Journal of biological chemistry | 21321127 | 2011 Apr 8 |
| Vpr-host interactions during HIV-1 viral life cycle. | Zhao, Richard Y; Li, Ge; Bukrinsky, Michael I | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 21318276 | 2011 Jun |
| Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones. | Fenster, Erik; Long, Toby R; Zang, Qin; Hill, David; Neuenswander, Benjamin; Lushington, Gerald H; Zhou, Aihua; Santini, Conrad; Hanson, Paul R | ACS combinatorial science | 21309582 | 2011 May 9 |
| Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. | Choi, Jayoung; Mouillesseaux, Kevin; Wang, Zhiming; Fiji, Hannah D G; Kinderman, Sape S; Otto, Georg W; Geisler, Robert; Kwon, Ohyun; Chen, Jau-Nian | Development (Cambridge, England) | 21307094 | 2011 Mar |
| Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. | Gao, Xue; Chooi, Yit-Heng; Ames, Brian D; Wang, Peng; Walsh, Christopher T; Tang, Yi | Journal of the American Chemical Society | 21299212 | 2011 Mar 2 |
| Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents. | John, Renu; Nguyen, Freddy T; Kolbeck, Kenneth J; Chaney, Eric J; Marjanovic, Marina; Suslick, Kenneth S; Boppart, Stephen A | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging | 21298354 | 2012 Feb |
| Development of an HTS-compatible assay for discovery of RORýý modulators using AlphaScreenýý technology. | Istrate, Monica A; Spicer, Timothy P; Wang, Yan; Bernard, Jerrold A; Helvering, Leah M; Bocchinfuso, Wayne P; Richardson, Timothy I; Zink, Richard; Kumar, Naresh; Montrose-Rafizadeh, Chahrzad; Dodge, Jeffrey; Hodder, Peter; Griffin, Patrick R | Journal of biomolecular screening | 21297105 | 2011 Feb |
| Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents. | Yuan, Peixiong; Tragon, Tyson; Xia, Menghang; Leclair, Christopher A; Skoumbourdis, Amanda P; Zheng, Wei; Thomas, Craig J; Huang, Ruili; Austin, Christopher P; Chen, Guang; Guitart, Xavier | Pharmacology, biochemistry, and behavior | 21296104 | 2011 May |
| Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries. | Lopez-Vallejo, Fabian; Nefzi, Adel; Bender, Andreas; Owen, John R; Nabney, Ian T; Houghten, Richard A; Medina-Franco, Jose L | Chemical biology & drug design | 21294850 | 2011 May |
| Facile syntheses of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]-pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles. | Avila, Belem; Solano, Danielle M; Haddadin, Makhluf J; Kurth, Mark J | Organic letters | 21294577 | 2011 Mar 4 |
| Chiral kinase inhibitors. | Jiang, Jian-kang; Shen, Min; Thomas, Craig J; Boxer, Mathew B | Current topics in medicinal chemistry | 21291394 | 2011 |
| CEST MRI reporter genes. | Liu, Guanshu; Bulte, Jeff W M; Gilad, Assaf A | Methods in molecular biology (Clifton, N.J.) | 21279607 | 2011 |
| Amide proton transfer imaging of the human brain. | Zhou, Jinyuan | Methods in molecular biology (Clifton, N.J.) | 21279604 | 2011 |
| Off-resonance saturation MRI of superparamagnetic nanoprobes: theoretical models and experimental validations. | Khemtong, Chalermchai; Togao, Osamu; Ren, Jimin; Kessinger, Chase W; Takahashi, Masaya; Sherry, A Dean; Gao, Jinming | Journal of magnetic resonance (San Diego, Calif. : 1997) | 21277813 | 2011 Mar |
| Synthesis and diversification of 1,2,3-triazole-fused 1,4-benzodiazepine scaffolds. | Donald, James R; Martin, Stephen F | Organic letters | 21275426 | 2011 Mar 4 |
| PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. | Huesa, Carmen; Yadav, Manisha C; Finnila, Mikko A J; Goodyear, Simon R; Robins, Simon P; Tanner, K Elizabeth; Aspden, Richard M; Millan, Jose Luis; Farquharson, Colin | Bone | 21272676 | 2011 May 1 |
| Defects in beta cell Caýý+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. | Benninger, R K P; Remedi, M S; Head, W S; Ustione, A; Piston, D W; Nichols, C G | Diabetologia | 21271337 | 2011 May |
| Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein. | Haushalter, Robert W; Filipp, Fabian V; Ko, Kwang-Seuk; Yu, Ricky; Opella, Stanley J; Burkart, Michael D | ACS chemical biology | 21268653 | 2011 May 20 |
| Pyrrole-based scaffolds for turn mimics. | Ko, Eunhwa; Burgess, Kevin | Organic letters | 21268601 | 2011 Mar 4 |
| Narrow groove plasmonic nano-gratings for surface plasmon resonance sensing. | Dhawan, Anuj; Canva, Michael; Vo-Dinh, Tuan | Optics express | 21263620 | 2011 Jan 17 |
| Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. | Prast-Nielsen, Stefanie; Dexheimer, Thomas S; Schultz, Lena; Stafford, William C; Cheng, Qing; Xu, Jianqiang; Jadhav, Ajit; Arner, Elias S J; Simeonov, Anton | Free radical biology & medicine | 21262347 | 2011 May 1 |
| Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa. | Kwan, Jason Christopher; Meickle, Theresa; Ladwa, Dheran; Teplitski, Max; Paul, Valerie; Luesch, Hendrik | Molecular bioSystems | 21258753 | 2011 Apr |
| An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells. | Zhu, Wenge; Lee, Chrissie Y; Johnson, Ronald L; Wichterman, Jennifer; Huang, Ruili; DePamphilis, Melvin L | Molecular cancer research : MCR | 21257818 | 2011 Mar |
| A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. | Abi-Ghanem, Daad; Lai, Xinzhong; Berghman, Luc R; Horvat, Darijana; Li, Jing; Romo, Daniel; Uddin, Mohammad N; Kamano, Yoshiaki; Nogawa, Toshihiko; Xu, Jun-Ping; Pettit, George R; Puschett, Jules B | Journal of immunoassay & immunochemistry | 21253968 | 2011 |
| New regulators of a high affinity Ca2+ influx system revealed through a genome-wide screen in yeast. | Martin, D Christian; Kim, Hyemin; Mackin, Nancy A; Maldonado-Baez, Lymarie; Evangelista Jr, Carlos C; Beaudry, Veronica G; Dudgeon, Drew D; Naiman, Daniel Q; Erdman, Scott E; Cunningham, Kyle W | The Journal of biological chemistry | 21252230 | 2011 Mar 25 |
| Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. | Marugan, Juan J; Zheng, Wei; Motabar, Omid; Southall, Noel; Goldin, Ehud; Westbroek, Wendy; Stubblefield, Barbara K; Sidransky, Ellen; Aungst, Ronald A; Lea, Wendy A; Simeonov, Anton; Leister, William; Austin, Christopher P | Journal of medicinal chemistry | 21250698 | 2011 Feb 24 |
| The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. | Bekes, Miklos; Prudden, John; Srikumar, Tharan; Raught, Brian; Boddy, Michael N; Salvesen, Guy S | The Journal of biological chemistry | 21247896 | 2011 Mar 25 |
| Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. | Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R; Clardy, Jon | Organic letters | 21247188 | 2011 Feb 18 |
| Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. | Engers, Darren W; Field, Julie R; Le, Uyen; Zhou, Ya; Bolinger, Julie D; Zamorano, Rocio; Blobaum, Anna L; Jones, Carrie K; Jadhav, Satyawan; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R | Journal of medicinal chemistry | 21247167 | 2011 Feb 24 |
| Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats. | Mullin, Lee; Gessner, Ryan; Kwan, James; Kaya, Mehmet; Borden, Mark A; Dayton, Paul A | Contrast media & molecular imaging | 21246710 | 2011 May-Jun |
| High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4. | Shu, Chih-Wen; Madiraju, Charitha; Zhai, Dayong; Welsh, Kate; Diaz, Paul; Sergienko, Eduard; Sano, Renata; Reed, John C | Journal of biomolecular screening | 21245471 | 2011 Feb |
| Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity. | Smith 3rd, Amos B; Kim, Won-Suk | Proceedings of the National Academy of Sciences of the United States of America | 21245309 | 2011 Apr 26 |
| APOBEC3G: a double agent in defense. | Smith, Harold C | Trends in biochemical sciences | 21239176 | 2011 May |
| Nano-fibrous tissue engineering scaffolds capable of growth factor delivery. | Hu, Jiang; Ma, Peter X | Pharmaceutical research | 21234657 | 2011 Jun |
| The ecology and pathobiology of Clostridium difficile infections: an interdisciplinary challenge. | Dubberke, E R; Haslam, D B; Lanzas, C; Bobo, L D; Burnham, C-A D; Grohn, Y T; Tarr, P I | Zoonoses and public health | 21223531 | 2011 Feb |
| Label-Free Receptor Assays. | Fang, Ye | Drug discovery today. Technologies | 21221420 | 2011 |
| Helix 11 dynamics is critical for constitutive androstane receptor activity. | Wright, Edward; Busby, Scott A; Wisecarver, Sarah; Vincent, Jeremy; Griffin, Patrick R; Fernandez, Elias J | Structure (London, England : 1993) | 21220114 | 2011 Jan 12 |
| A Java API for working with PubChem datasets. | Southern, Mark R; Griffin, Patrick R | Bioinformatics (Oxford, England) | 21216779 | 2011 Mar 1 |
| Discovery of selective irreversible inhibitors for EGFR-T790M. | Zhou, Wenjun; Ercan, Dalia; Janne, Pasi A; Gray, Nathanael S | Bioorganic & medicinal chemistry letters | 21208802 | 2011 Jan 15 |
| Receptor-mediated T cell absorption of antigen presenting cell-derived molecules. | Hwang, Inkyu; Ki, DaLim | Frontiers in bioscience : a journal and virtual library | 21196178 | 2011 |
| Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. | Reid, Paul R; Bridges, Thomas M; Sheffler, Douglas J; Cho, Hyekyung P; Lewis, L Michelle; Days, Emily; Daniels, J Scott; Jones, Carrie K; Niswender, Colleen M; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R | Bioorganic & medicinal chemistry letters | 21194936 | 2011 May 1 |
| Oxidation of organotrifluoroborates via oxone. | Molander, Gary A; Cavalcanti, Livia N | The Journal of organic chemistry | 21192650 | 2011 Jan 21 |
| Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. | Cencic, Regina; Hall, David R; Robert, Francis; Du, Yuhong; Min, Jaeki; Li, Lian; Qui, Min; Lewis, Iestyn; Kurtkaya, Serdar; Dingledine, Ray; Fu, Haian; Kozakov, Dima; Vajda, Sandor; Pelletier, Jerry | Proceedings of the National Academy of Sciences of the United States of America | 21191102 | 2011 Jan 18 |
| Polycyclic compounds by Ugi-Pictet-Spengler sequence. | Wang, Wei; Ollio, Sarah; Herdtweck, Eberhardt; Domling, Alexander | The Journal of organic chemistry | 21190371 | 2011 Jan 21 |
| Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids. | Vang, Torkel; Xie, Yuli; Liu, Wallace H; Vidovic, Dusica; Liu, Yidong; Wu, Shuangding; Smith, Deborah H; Rinderspacher, Alison; Chung, Caty; Gong, Gangli; Mustelin, Tomas; Landry, Donald W; Rickert, Robert C; Schurer, Stephan C; Deng, Shi-Xian; Tautz, Lut | Journal of medicinal chemistry | 21190368 | 2011 Jan 27 |
| Insights into the structural basis of RNA recognition by STAR domain proteins. | Ryder, Sean P; Massi, Francesca | Advances in experimental medicine and biology | 21189684 | 2010 |
| Titanium-catalyzed stereoselective synthesis of spirooxindole oxazolines. | Badillo, Joseph J; Arevalo, Gary E; Fettinger, James C; Franz, Annaliese K | Organic letters | 21186788 | 2011 Feb 4 |
| Activity-guided engineering of natural product carrier proteins. | Worthington, Andrew S; Hur, Gene H; Burkart, Michael D | Molecular bioSystems | 21184004 | 2011 Feb |
| Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. | Rico-Bautista, Elizabeth; Yang, Chih-Cheng; Lu, Lifang; Roth, Gregory P; Wolf, Dieter A | BMC biology | 21182779 | 2010 |
| Universal peptidomimetics. | Ko, Eunhwa; Liu, Jing; Perez, Lisa M; Lu, Genliang; Schaefer, Amber; Burgess, Kevin | Journal of the American Chemical Society | 21182254 | 2011 Jan 26 |
| CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice. | Wang, Qiang; Hillwig, Matthew L; Peters, Reuben J | The Plant journal : for cell and molecular biology | 21175892 | 2011 Jan |
| Spectroscopic optical coherence elastography. | Adie, Steven G; Liang, Xing; Kennedy, Brendan F; John, Renu; Sampson, David D; Boppart, Stephen A | Optics express | 21164898 | 2010 Dec 6 |
| CYANOS: a data management system for natural product drug discovery efforts using cultured microorganisms. | Chlipala, George E; Krunic, Aleksej; Mo, Shunyan; Sturdy, Megan; Orjala, Jimmy | Journal of chemical information and modeling | 21162567 | 2011 Jan 24 |
| A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARýý partial agonists. | Vidovic, Dusica; Busby, Scott A; Griffin, Patrick R; Schurer, Stephan C | ChemMedChem | 21162086 | 2011 Jan 3 |
| Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review. | Shun, Tong Ying; Lazo, John S; Sharlow, Elizabeth R; Johnston, Paul A | Journal of biomolecular screening | 21160066 | 2011 Jan |
| Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-a-go-go related gene potassium channels. | Zou, Beiyan; Yu, Haibo; Babcock, Joseph J; Chanda, Pritam; Bader, Joel S; McManus, Owen B; Li, Min | Assay and drug development technologies | 21158688 | 2010 Dec |
| Cooperative epigenetic modulation by cancer amplicon genes. | Rui, Lixin; Emre, N C Tolga; Kruhlak, Michael J; Chung, Hye-Jung; Steidl, Christian; Slack, Graham; Wright, George W; Lenz, Georg; Ngo, Vu N; Shaffer, Arthur L; Xu, Weihong; Zhao, Hong; Yang, Yandan; Lamy, Laurence; Davis, R Eric; Xiao, Wenming; Powell, John; Maloney, David; Thomas, Craig J; Moller, Peter; Rosenwald, Andreas; Ott, German; Muller-Hermelink, Hans Konrad; Savage, Kerry; Connors, Joseph M; Rimsza, Lisa M; Campo, Elias; Jaffe, Elaine S; Delabie, Jan; Smeland, Erlend B; Weisenburger, Dennis D; Chan, Wing C; Gascoyne, Randy D; Levens, David; Staudt, Louis M | Cancer cell | 21156283 | 2010 Dec 14 |
| Paramagnetic relaxation assisted docking of a small indole compound in the HIV-1 gp41 hydrophobic pocket. | Gochin, Miriam; Zhou, Guangyan; Phillips, Aaron H | ACS chemical biology | 21155611 | 2011 Mar 18 |
| The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis. | Bugreev, Dmitry V; Pezza, Roberto J; Mazina, Olga M; Voloshin, Oleg N; Camerini-Otero, R Daniel; Mazin, Alexander V | Nature structural & molecular biology | 21151113 | 2011 Jan |
| Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. | Montaser, Rana; Abboud, Khalil A; Paul, Valerie J; Luesch, Hendrik | Journal of natural products | 21138309 | 2011 Jan 28 |
| High content screening for non-classical peroxisome proliferators. | Sexton, Jonathan Z; He, Qingping; Forsberg, Lawrence J; Brenman, Jay E | International journal of high throughput screening | 21132080 | 2010 Jul |
| Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. | Chigaev, Alexandre; Wu, Yang; Williams, D Bart; Smagley, Yelena; Sklar, Larry A | The Journal of biological chemistry | 21131351 | 2011 Feb 18 |
| Modeling general proteostasis: proteome balance in health and disease. | Roth, Daniela M; Balch, William E | Current opinion in cell biology | 21131189 | 2011 Apr |
| Fabry disease - current treatment and new drug development. | Motabar O, Sidransky E, Goldin E, Zheng W. | Curr Chem Genomics | 21127742 | 2010 Jul 23 |
| Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. | King, Oliver N F; Li, Xuan Shirley; Sakurai, Masaaki; Kawamura, Akane; Rose, Nathan R; Ng, Stanley S; Quinn, Amy M; Rai, Ganesha; Mott, Bryan T; Beswick, Paul; Klose, Robert J; Oppermann, Udo; Jadhav, Ajit; Heightman, Tom D; Maloney, David J; Schofield, Christopher J; Simeonov, Anton | PloS one | 21124847 | 2010 |
| A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. | Neumann, Susanne; Eliseeva, Elena; McCoy, Joshua G; Napolitano, Giorgio; Giuliani, Cesidio; Monaco, Fabrizio; Huang, Wenwei; Gershengorn, Marvin C | The Journal of clinical endocrinology and metabolism | 21123444 | 2011 Feb |
| Quantum dots for quantitative flow cytometry. | Buranda, Tione; Wu, Yang; Sklar, Larry A | Methods in molecular biology (Clifton, N.J.) | 21116979 | 2011 |
| Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline. | Wipf, Peter; George, Kara M | Synlett : accounts and rapid communications in synthetic organic chemistry | 21116479 | 2010 Mar 1 |
| Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. | McCoy, Joshua G; Marugan, Juan J; Liu, Ke; Zheng, Wei; Southall, Noel; Huang, Wenwei; Heilig, Markus; Austin, Christopher P | ACS chemical neuroscience | 21116448 | 2010 Aug 18 |
| Clearance (nee Rowland) concepts: a downdate and an update. | Benet, Leslie Z | Journal of pharmacokinetics and pharmacodynamics | 21113650 | 2010 Dec |
| A new approach to desketoraloxifene analogs from oxygen-bearing 3-iodobenzo[b]thiophenes prepared via iodocyclization. | Cho, Chul-Hee; Jung, Dai-Il; Larock, Richard C | Tetrahedron letters | 21113432 | 2010 Dec 15 |
| PROBING CANCER SIGNALING WITH RESONANT WAVEGUIDE GRATING BIOSENSORS. | Fang, Ye | Expert opinion on drug discovery | 21113317 | 2010 Dec |
| CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. | Ju, Wei; Zhang, Meili; Jiang, Jian-kang; Thomas, Craig J; Oh, Unsong; Bryant, Bonita R; Chen, Jing; Sato, Noriko; Tagaya, Yutaka; Morris, John C; Janik, John E; Jacobson, Steven; Waldmann, Thomas A | Blood | 21106989 | 2011 Feb 10 |
| Encapsulated energy-transfer cassettes with extremely well resolved fluorescent outputs. | Ueno, Yuichiro; Jose, Jiney; Loudet, Aurore; Perez-Bolivar, Cesar; Anzenbacher Jr, Pavel; Burgess, Kevin | Journal of the American Chemical Society | 21105708 | 2011 Jan 12 |
| A stabilizing influence: CAL PDZ inhibition extends the half-life of ýýF508-CFTR. | Cushing, Patrick R; Vouilleme, Lars; Pellegrini, Maria; Boisguerin, Prisca; Madden, Dean R | Angewandte Chemie (International ed. in English) | 21105033 | 2010 Dec 17 |
| WebPK, a web-based tool for custom pharmacokinetic simulation. | Srimani, Jaydeep; Moffitt, Richard A; Wang, May D | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | 21096365 | 2010 |
| Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop. | Critton, David A; Tautz, Lutz; Page, Rebecca | Journal of molecular biology | 21094165 | 2011 Jan 21 |
| Identification of SR3335 (ML-176): a synthetic RORýý selective inverse agonist. | Kumar, Naresh; Kojetin, Douglas J; Solt, Laura A; Kumar, K Ganesh; Nuhant, Philippe; Duckett, Derek R; Cameron, Michael D; Butler, Andrew A; Roush, William R; Griffin, Patrick R; Burris, Thomas P | ACS chemical biology | 21090593 | 2011 Mar 18 |
| Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes. | Yang, Jane Y; Karr, Jessica R; Watrous, Jeramie D; Dorrestein, Pieter C | Current opinion in chemical biology | 21087892 | 2011 Feb |
| Quantitative reactivity profiling predicts functional cysteines in proteomes. | Weerapana, Eranthie; Wang, Chu; Simon, Gabriel M; Richter, Florian; Khare, Sagar; Dillon, Myles B D; Bachovchin, Daniel A; Mowen, Kerri; Baker, David; Cravatt, Benjamin F | Nature | 21085121 | 2010 Dec 9 |
| High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. | Chen, Catherine Z; Kulakova, Liudmila; Southall, Noel; Marugan, Juan J; Galkin, Andrey; Austin, Christopher P; Herzberg, Osnat; Zheng, Wei | Antimicrobial agents and chemotherapy | 21078930 | 2011 Feb |
| A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation. | Ezzeddine, Nader; Chen, Jiandong; Waltenspiel, Bernhard; Burch, Brandon; Albrecht, Todd; Zhuo, Ming; Warren, William D; Marzluff, William F; Wagner, Eric J | Molecular and cellular biology | 21078872 | 2011 Jan |
| Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts? | Johnston, Paul A | Current opinion in chemical biology | 21075044 | 2011 Feb |
| Human ferritin cages for imaging vascular macrophages. | Terashima, Masahiro; Uchida, Masaki; Kosuge, Hisanori; Tsao, Philip S; Young, Mark J; Conolly, Steven M; Douglas, Trevor; McConnell, Michael V | Biomaterials | 21074263 | 2011 Feb |
| High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. | Niesen, Frank H; Schultz, Lena; Jadhav, Ajit; Bhatia, Chitra; Guo, Kunde; Maloney, David J; Pilka, Ewa S; Wang, Minghua; Oppermann, Udo; Heightman, Tom D; Simeonov, Anton | PloS one | 21072165 | 2010 |
| NMR-spectroscopic analysis of mixtures: from structure to function. | Forseth, Ry R; Schroeder, Frank C | Current opinion in chemical biology | 21071261 | 2011 Feb |
| Practical 4'-phosphopantetheine active site discovery from proteomic samples. | Meier, Jordan L; Patel, Anand D; Niessen, Sherry; Meehan, Michael; Kersten, Roland; Yang, Jane Y; Rothmann, Michael; Cravatt, Benjamin F; Dorrestein, Pieter C; Burkart, Michael D; Bafna, Vineet | Journal of proteome research | 21067235 | 2011 Jan 7 |
| Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines. | Haddadin, Makhluf J; Bou Zerdan, Raghida M; Kurth, Mark J; Fettinger, James C | Organic letters | 21067220 | 2010 Dec 3 |
| Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. | Dorjsuren, Dorjbal; Kim, Daemyung; Maloney, David J; Wilson 3rd, David M; Simeonov, Anton | Nucleic acids research | 21062821 | 2011 Jan |
| Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen. | Maddry, Joseph A; Chen, Xi; Jonsson, Colleen B; Ananthan, Subramaniam; Hobrath, Judith; Smee, Donald F; Noah, James W; Noah, Diana; Xu, Xiaolin; Jia, Fuli; Maddox, Clinton; Sosa, Melinda I; White, E Lucile; Severson, William E | Journal of biomolecular screening | 21059874 | 2011 Jan |
| Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii. | Krunic, Aleksej; Vallat, Armelle; Mo, Shunyan; Lantvit, Daniel D; Swanson, Steven M; Orjala, Jimmy | Journal of natural products | 21058727 | 2010 Nov 29 |
| Metabolomics of urine for the assessment of microvesicular lipid accumulation in the liver following isoniazid exposure. | Sumner, Susan J; Burgess, Jason P; Snyder, Rodney W; Popp, James A; Fennell, Timothy R | Metabolomics : Official journal of the Metabolomic Society | 21057652 | 2010 Jun 1 |
| Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach. | Pinto, Jose Renato; Reynaldo, Daniel P; Parvatiyar, Michelle S; Dweck, David; Liang, Jingsheng; Jones, Michelle A; Sorenson, Martha M; Potter, James D | The Journal of biological chemistry | 21056975 | 2011 Jan 14 |
| Atomic-level characterization of the ensemble of the Aýý(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms. | Sgourakis, Nikolaos G; Merced-Serrano, Myrna; Boutsidis, Christos; Drineas, Petros; Du, Zheming; Wang, Chunyu; Garcia, Angel E | Journal of molecular biology | 21056574 | 2011 Jan 14 |
| Emergent properties of proteostasis-COPII coupled systems in human health and disease. | Routledge, Katy E; Gupta, Vijay; Balch, William E | Molecular membrane biology | 21054154 | 2010 Nov |
| Identification and characterization of steroidogenic factor-1 inverse agonists. | Doghman, Mabrouka; Madoux, Franck; Hodder, Peter; Lalli, Enzo | Methods in enzymology | 21050908 | 2010 |
| Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. | Ashley, Jason W; McCoy, Erin M; Clements, Daniel A; Shi, Zhenqi; Chen, Taosheng; Feng, Xu | Assay and drug development technologies | 21050071 | 2011 Feb |
| A high-throughput screening strategy to overcome virus instability. | Rasmussen, Lynn; Maddox, Clinton; Moore, Blake P; Severson, William; White, E Lucile | Assay and drug development technologies | 21050067 | 2011 Apr |
| Identification of novel small molecule activators of nuclear factor-ýýB with neuroprotective action via high-throughput screening. | Manuvakhova, Marina S; Johnson, Guyla G; White, Misti C; Ananthan, Subramaniam; Sosa, Melinda; Maddox, Clinton; McKellip, Sara; Rasmussen, Lynn; Wennerberg, Krister; Hobrath, Judith V; White, E Lucile; Maddry, Joseph A; Grimaldi, Maurizio | Journal of neuroscience research | 21046675 | 2011 Jan |
| Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. | Kojetin, Douglas; Wang, Yongjun; Kamenecka, Theodore M; Burris, Thomas P | ACS chemical biology | 21043485 | 2011 Feb 18 |
| Two-step Hantzsch based macrocyclization approach for the synthesis of thiazole-containing cyclopeptides. | Nefzi, Adel; Arutyunyan, Sergey; Fenwick, Jason E | The Journal of organic chemistry | 21033717 | 2010 Nov 19 |
| Applicability domains for classification problems: Benchmarking of distance to models for Ames mutagenicity set. | Sushko, Iurii; Novotarskyi, Sergii; Korner, Robert; Pandey, Anil Kumar; Cherkasov, Artem; Li, Jiazhong; Gramatica, Paola; Hansen, Katja; Schroeter, Timon; Muller, Klaus-Robert; Xi, Lili; Liu, Huanxiang; Yao, Xiaojun; Oberg, Tomas; Hormozdiari, Farhad; Dao | Journal of chemical information and modeling | 21033656 | 2010 Dec 27 |
| A rapid and efficient route to benzazole heterocycles. | Carpenter, Richard D; Kurth, Mark J | Nature protocols | 21030949 | 2010 Nov |
| Proteostasis strategies for restoring alpha1-antitrypsin deficiency. | Bouchecareilh, Marion; Conkright, Juliana J; Balch, William E | Proceedings of the American Thoracic Society | 21030523 | 2010 Nov |
| The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in ýý-cells. | Kaufman, R J; Back, S H; Song, B; Han, J; Hassler, J | Diabetes, obesity & metabolism | 21029306 | 2010 Oct |
| Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. | Sedykh, Alexander; Zhu, Hao; Tang, Hao; Zhang, Liying; Richard, Ann; Rusyn, Ivan; Tropsha, Alexander | Environmental health perspectives | 20980217 | 2011 Mar |
| The dopamine metabolite 3-methoxytyramine is a neuromodulator. | Sotnikova, Tatyana D; Beaulieu, Jean-Martin; Espinoza, Stefano; Masri, Bernard; Zhang, Xiaodong; Salahpour, Ali; Barak, Larry S; Caron, Marc G; Gainetdinov, Raul R | PloS one | 20976142 | 2010 |
| Alkylation of the tumor suppressor PTEN activates Akt and ýý-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. | Covey, Tracy M; Edes, Kornelia; Coombs, Gary S; Virshup, David M; Fitzpatrick, Frank A | PloS one | 20975834 | 2010 |
| Identification of clinically used drugs that activate pregnane X receptors. | Shukla, Sunita J; Sakamuru, Srilatha; Huang, Ruili; Moeller, Timothy A; Shinn, Paul; Vanleer, Danielle; Auld, Douglas S; Austin, Christopher P; Xia, Menghang | Drug metabolism and disposition: the biological fate of chemicals | 20966043 | 2011 Jan |
| Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua. | Mo, Shunyan; Krunic, Aleksej; Santarsiero, Bernard D; Franzblau, Scott G; Orjala, Jimmy | Phytochemistry | 20965528 | 2010 Dec |
| One-step continuous flow synthesis of highly substituted pyrrole-3-carboxylic acid derivatives via in situ hydrolysis of tert-butyl esters. | Herath, Ananda; Cosford, Nicholas D P | Organic letters | 20964284 | 2010 Nov 19 |
| Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. | Zhou, Hui; Qiao, Kangjian; Gao, Zhizeng; Vederas, John C; Tang, Yi | The Journal of biological chemistry | 20961859 | 2010 Dec 31 |
| Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. | Hajjo, Rima; Grulke, Christopher M; Golbraikh, Alexander; Setola, Vincent; Huang, Xi-Ping; Roth, Bryan L; Tropsha, Alexander | Journal of medicinal chemistry | 20958049 | 2010 Nov 11 |
| Synthesis of amino acid derived enaminones via Wolff rearrangement using vinylogous amides as carbon nucleophiles. | Seki, Hajime; Georg, Gunda I | Journal of the American Chemical Society | 20958040 | 2010 Nov 10 |
| Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. | Clemons, Paul A; Bodycombe, Nicole E; Carrinski, Hyman A; Wilson, J Anthony; Shamji, Alykhan F; Wagner, Bridget K; Koehler, Angela N; Schreiber, Stuart L | Proceedings of the National Academy of Sciences of the United States of America | 20956335 | 2010 Nov 2 |
| Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. | Mao, Yang; Xu, Xianzhong; Xu, Wei; Ishida, Yuko; Leal, Walter S; Ames, James B; Clardy, Jon | Proceedings of the National Academy of Sciences of the United States of America | 20956299 | 2010 Nov 2 |
| Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer. | Zhang, Jun; Chalmers, Michael J; Stayrook, Keith R; Burris, Lorri L; Garcia-Ordonez, Ruben D; Pascal, Bruce D; Burris, Thomas P; Dodge, Jeffery A; Griffin, Patrick R | Structure (London, England : 1993) | 20947021 | 2010 Oct 13 |
| A disease-relevant high-content screening assay to identify anti-inflammatory compounds for use in cystic fibrosis. | Giddings, Angela M; Maitra, Rangan | Journal of biomolecular screening | 20944057 | 2010 Dec |
| Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. | Larson, Peder E Z; Hu, Simon; Lustig, Michael; Kerr, Adam B; Nelson, Sarah J; Kurhanewicz, John; Pauly, John M; Vigneron, Daniel B | Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine | 20939089 | 2011 Mar |
| Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. | Saunders, Matthew J; Edwards, Bruce S; Zhu, Jingshu; Sklar, Larry A; Graves, Steven W | Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] | 20938917 | 2010 Oct |
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| Synthesis of dihydrobenzisoxazoles by the [3 + 2] cycloaddition of arynes and oxaziridines. | Kivrak, Arif; Larock, Richard C | The Journal of organic chemistry | 20936802 | 2010 Nov 5 |
| Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs. | Marsolais, David; Yagi, Saiko; Kago, Tomoyuki; Leaf, Nora; Rosen, Hugh | Molecular pharmacology | 20935081 | 2011 Jan |
| Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1. | Thompson, Scott; Messick, Troy; Schultz, David C; Reichman, Melvin; Lieberman, Paul M | Journal of biomolecular screening | 20930215 | 2010 Oct |
| A high-throughput, homogeneous, fluorescence polarization assay for inhibitors of hedgehog protein autoprocessing. | Jiang, Shu-qin; Paulus, Henry | Journal of biomolecular screening | 20930213 | 2010 Oct |
| Synthesis of 6- and 7-membered cyclic enaminones: scope and mechanism. | Niphakis, Micah J; Turunen, Brandon J; Georg, Gunda I | The Journal of organic chemistry | 20929269 | 2010 Oct 15 |
| Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases. | Daher, Racha; Coincon, Mathieu; Fonvielle, Matthieu; Gest, Petra M; Guerin, Marcelo E; Jackson, Mary; Sygusch, Jurgen; Therisod, Michel | Journal of medicinal chemistry | 20929256 | 2010 Nov 11 |
| Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. | Bhave, Gautam; Chauder, Brian A; Liu, Wen; Dawson, Eric S; Kadakia, Rishin; Nguyen, Thuy T; Lewis, L Michelle; Meiler, Jens; Weaver, C David; Satlin, Lisa M; Lindsley, Craig W; Denton, Jerod S | Molecular pharmacology | 20926757 | 2011 Jan |
| Coupling of receptor conformation and ligand orientation determine graded activity. | Bruning, John B; Parent, Alexander A; Gil, German; Zhao, Min; Nowak, Jason; Pace, Margaret C; Smith, Carolyn L; Afonine, Pavel V; Adams, Paul D; Katzenellenbogen, John A; Nettles, Kendall W | Nature chemical biology | 20924370 | 2010 Nov |
| Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009. | Dolle, Roland E; Bourdonnec, Bertrand Le; Worm, Karin; Morales, Guillermo A; Thomas, Craig J; Zhang, Wei | Journal of combinatorial chemistry | 20923157 | 2010 Nov 8 |
| Two rings in them all: the labdane-related diterpenoids. | Peters, Reuben J | Natural product reports | 20890488 | 2010 Nov |
| Chembench: a cheminformatics workbench. | Walker, Theo; Grulke, Christopher M; Pozefsky, Diane; Tropsha, Alexander | Bioinformatics (Oxford, England) | 20889496 | 2010 Dec 1 |
| Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase. | Mousseau, G; Kota, S; Takahashi, V; Frick, D N; Strosberg, A D | The Journal of general virology | 20881089 | 2011 Jan |
| S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides. | Rolfe, Alan; Samarakoon, Thiwanka B; Klimberg, Sarra V; Brzozowski, Marek; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul R | Journal of combinatorial chemistry | 20879738 | 2010 Nov 8 |
| Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. | Tinsley, Heather N; Gary, Bernard D; Thaiparambil, Jose; Li, Nan; Lu, Wenyan; Li, Yonghe; Maxuitenko, Yulia Y; Keeton, Adam B; Piazza, Gary A | Cancer prevention research (Philadelphia, Pa.) | 20876730 | 2010 Oct |
| Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. | Feng, Jianying; Petersen, Clark D; Coy, David H; Jiang, Jian-Kang; Thomas, Craig J; Pollak, Martin R; Wank, Stephen A | Proceedings of the National Academy of Sciences of the United States of America | 20876097 | 2010 Oct 12 |
| Small molecule peptidomimetic inhibitors of importin ýý/ýý mediated nuclear transport. | Ambrus, Geza; Whitby, Landon R; Singer, Eric L; Trott, Oleg; Choi, Euna; Olson, Arthur J; Boger, Dale L; Gerace, Larry | Bioorganic & medicinal chemistry | 20869252 | 2010 Nov 1 |
| Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. | Rai, Ganesha; Kenyon, Victor; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson, J Brian; Hoobler, Eric; Leister, William; Simeonov, Anton; Holman, Theodore R; Maloney, David J | Journal of medicinal chemistry | 20866075 | 2010 Oct 28 |
| Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS. | Zhou, Guangchang; Yan, Xiaoliang; Wu, Ding; Kron, Stephen J | Bioconjugate chemistry | 20860375 | 2010 Oct 20 |
| Diterpenoid biopolymers: new directions for renewable materials engineering. | Hillwig, Matthew L; Mann, Francis M; Peters, Reuben J | Biopolymers | 20857504 | 2011 Feb |
| Integrating computational and mixture-based screening of combinatorial libraries. | Yongye, Austin B; Pinilla, Clemencia; Medina-Franco, Jose L; Giulianotti, Marc A; Dooley, Colette T; Appel, Jon R; Nefzi, Adel; Scior, Thomas; Houghten, Richard A; Martinez-Mayorga, Karina | Journal of molecular modeling | 20853183 | 2011 Jun |
| Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. | Joyner, P Matthew; Liu, Jinman; Zhang, Zhijun; Merritt, Justin; Qi, Fengxia; Cichewicz, Robert H | Organic & biomolecular chemistry | 20852771 | 2010 Dec 21 |
| Fluorous diastereomeric mixture synthesis (FDMS) of hydantoin-fused hexahydrochromeno[4,3-b]pyrroles. | Lu, Yimin; Geib, Steven J; Damodaran, Krishnan; Sui, Bin; Zhang, Zijuan; Curran, Dennis P; Zhang, Wei | Chemical communications (Cambridge, England) | 20844802 | 2010 Oct 28 |
| Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain. | Cao, Shugeng; Blodgett, Joshua A V; Clardy, Jon | Organic letters | 20843016 | 2010 Oct 15 |
| Fluorine (19F) MRS and MRI in biomedicine. | Ruiz-Cabello, Jesus; Barnett, Brad P; Bottomley, Paul A; Bulte, Jeff W M | NMR in biomedicine | 20842758 | 2011 Feb |
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| The ups and downs of structure-activity landscapes. | Guha, Rajarshi | Methods in molecular biology (Clifton, N.J.) | 20838965 | 2011 |
| Bioluminescence assay for detecting cell surface membrane protein expression. | Kato, Mieko; Chiba, Tomoki; Li, Min; Hanyu, Yoshiro | Assay and drug development technologies | 20836709 | 2011 Feb |
| Cardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discovery. | Macrae, Calum A | Expert opinion on drug discovery | 20835353 | 2010 Jul |
| Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation. | Yao, Nianhuan; Fung, Gabriel; Malekan, Hamed; Ye, Long; Kurth, Mark J; Lam, Kit S | Carbohydrate research | 20832778 | 2010 Oct 13 |
| Does the mass spectrometer define the marker? A comparison of global metabolite profiling data generated simultaneously via UPLC-MS on two different mass spectrometers. | Gika, Helen G; Theodoridis, Georgios A; Earll, Mark; Snyder, Rodney W; Sumner, Susan J; Wilson, Ian D | Analytical chemistry | 20828141 | 2010 Oct 1 |
| Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. | Xu, Wei; Cai, Xiaolu; Jung, Michael E; Tang, Yi | Journal of the American Chemical Society | 20828130 | 2010 Oct 6 |
| Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and ýý-arrestin2 with antinociceptive activity. | Zhao, Pingwei; Sharir, Haleli; Kapur, Ankur; Cowan, Alan; Geller, Ellen B; Adler, Martin W; Seltzman, Herbert H; Reggio, Patricia H; Heynen-Genel, Susanne; Sauer, Michelle; Chung, Thomas D Y; Bai, Yushi; Chen, Wei; Caron, Marc G; Barak, Larry S; Abood, Ma | Molecular pharmacology | 20826425 | 2010 Oct |
| Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research. | Bierwolf, Jeanette; Lutgehetmann, Marc; Feng, Kai; Erbes, Johannes; Deichmann, Steffen; Toronyi, Eva; Stieglitz, Christina; Nashan, Bjoern; Ma, Peter X; Pollok, Joerg M | Biotechnology and bioengineering | 20824672 | 2011 Jan |
| Imaging dynamic cellular events with quantum dots The bright future. | Smith, Andrew M; Wen, Mary M; Nie, Shuming | The biochemist | 20824157 | 2010 Jun 1 |
| Characterization of nanoprobe uptake in single cells: spatial and temporal tracking via SERS labeling and modulation of surface charge. | Gregas, Molly K; Yan, Fei; Scaffidi, Jonathan; Wang, Hsin-Neng; Vo-Dinh, Tuan | Nanomedicine : nanotechnology, biology, and medicine | 20817123 | 2011 Feb |
| Identification of novel inhibitors of dietary lipid absorption using zebrafish. | Clifton, Justin D; Lucumi, Edinson; Myers, Michael C; Napper, Andrew; Hama, Kotaro; Farber, Steven A; Smith 3rd, Amos B; Huryn, Donna M; Diamond, Scott L; Pack, Michael | PloS one | 20811635 | 2010 |
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| Small molecule inhibitors of DNA repair nuclease activities of APE1. | Wilson 3rd, David M; Simeonov, Anton | Cellular and molecular life sciences : CMLS | 20809131 | 2010 Nov |
| Quantitative volumetric perfusion mapping of the microvasculature using contrast ultrasound. | Feingold, Steven; Gessner, Ryan; Guracar, Ismayil M; Dayton, Paul A | Investigative radiology | 20808232 | 2010 Oct |
| A magnetic bead-based protein kinase assay with dual detection techniques. | Zhou, Guangchang; Sylvester, Juliesta E; Wu, Ding; Veach, Darren R; Kron, Stephen J | Analytical biochemistry | 20807497 | 2011 Jan 1 |
| Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. | Salvador, Lilibeth A; Paul, Valerie J; Luesch, Hendrik | Journal of natural products | 20806908 | 2010 Sep 24 |
| Improving success by balanced critical evaluations of assay methods. | Inglese J, Napper A, Auld D. | Assay Drug Dev Technol | 20804419 | 2010 Aug |
| Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. | Bridges, Thomas M; Kennedy, J Phillip; Hopkins, Corey R; Conn, P Jeffrey; Lindsley, Craig W | Bioorganic & medicinal chemistry letters | 20801651 | 2010 Oct 1 |
| Parallel synthesis and anti-inflammatory activity of cyclic peptides cyclosquamosin D and Met-cherimolacyclopeptide B and their analogs. | Dellai, Afef; Maricic, Igor; Kumar, Vipin; Arutyunyan, Sergey; Bouraoui, Abderrahman; Nefzi, Adel | Bioorganic & medicinal chemistry letters | 20801649 | 2010 Oct 1 |
| On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity. | Derbal, Safa; Hensler, Mary; Fang, Weiqin; Nizet, Victor; Ghedira, Kamel; Nefzi, Adel | Bioorganic & medicinal chemistry letters | 20800485 | 2010 Oct 1 |
| Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones. | Hammill, Jared T; Contreras-Garcia, Julia; Virshup, Aaron M; Beratan, David; Yang, Weitao; Wipf, Peter | Tetrahedron | 20798897 | 2010 Mar 31 |
| Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum. | Van Wagoner, Ryan M; Deeds, Jonathan R; Satake, Masayuki; Ribeiro, Anthony A; Place, Allen R; Wright, Jeffrey L C | Tetrahedron letters | 20798789 | 2008 Nov 3 |
| Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp. | Sturdy, Megan; Krunic, Aleksej; Cho, Sanghyun; Franzblau, Scott; Orjala, Jimmy | Journal of natural products | 20795743 | 2010 Aug 27 |
| Structure and relative potency of several karlotoxins from Karlodinium veneficum. | Van Wagoner, Ryan M; Deeds, Jonathan R; Tatters, Avery O; Place, Allen R; Tomas, Carmelo R; Wright, Jeffrey L C | Journal of natural products | 20795740 | 2010 Aug 27 |
| Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. | Lavieri, Robert R; Scott, Sarah A; Selvy, Paige E; Kim, Kwangho; Jadhav, Satyawan; Morrison, Ryan D; Daniels, J Scott; Brown, H Alex; Lindsley, Craig W | Journal of medicinal chemistry | 20735042 | 2010 Sep 23 |
| Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORýý and RORýý. | Wang, Yongjun; Kumar, Naresh; Nuhant, Philippe; Cameron, Michael D; Istrate, Monica A; Roush, William R; Griffin, Patrick R; Burris, Thomas P | ACS chemical biology | 20735016 | 2010 Nov 19 |
| New insights into repeat instability: role of RNAýýýDNA hybrids. | McIvor, Elizabeth I; Polak, Urszula; Napierala, Marek | RNA biology | 20729633 | 2010 Sep-Oct |
| Model-free drug-likeness from fragments. | Ursu, Oleg; Oprea, Tudor I | Journal of chemical information and modeling | 20726597 | 2010 Aug 23 |
| Preparation of FRET reporters to support chemical probe development. | Foley, Timothy L; Yasgar, Adam; Garcia, Christopher J; Jadhav, Ajit; Simeonov, Anton; Burkart, Michael D | Organic & biomolecular chemistry | 20725690 | 2010 Oct 21 |
| Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. | Martin, Michelle D; Kremers, Gert-Jan; Short, Kurt W; Rocheleau, Jonathan V; Xu, Lei; Piston, David W; Matrisian, Lynn M; Gorden, D Lee | Molecular cancer research : MCR | 20724460 | 2010 Oct |
| Recent methodologies toward the synthesis of valdecoxib: a potential 3,4-diarylisoxazolyl COX-II inhibitor. | Dadiboyena, Sureshbabu; Nefzi, Adel | European journal of medicinal chemistry | 20724040 | 2010 Nov |
| Highly ýý-selective hydrolysis of ýý,ýý-epoxyalcohols using tetrabutylammonium fluoride. | Mukerjee, Purba; Abid, Mohammed; Schroeder, Frank C | Organic letters | 20722386 | 2010 Sep 17 |
| Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists. | Letourneau JJ, Riviello CM, Li H, Cole AG, Ho KK, Zanetakos HA, Desai H, Zhao J, Auld DS, Napier SE, Thomson FJ, Goan KA, Morphy JR, Ohlmeyer MH, Webb ML. | Bioorg Med Chem Lett | 20719508 | 2010 Sep 15 |
| Surface-enhanced Raman scattering detection and tracking of nanoprobes: enhanced uptake and nuclear targeting in single cells. | Gregas, Molly K; Scaffidi, Jonathan P; Lauly, Benoit; Vo-Dinh, Tuan | Applied spectroscopy | 20719048 | 2010 Aug |
| A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. | Gianni, Davide; Taulet, Nicolas; Zhang, Hui; DerMardirossian, Celine; Kister, Jeremy; Martinez, Luis; Roush, William R; Brown, Steven J; Bokoch, Gary M; Rosen, Hugh | ACS chemical biology | 20715845 | 2010 Oct 15 |
| Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides. | Ullah, Farman; Samarakoon, Thiwanka; Rolfe, Alan; Kurtz, Ryan D; Hanson, Paul R; Organ, Michael G | Chemistry (Weinheim an der Bergstrasse, Germany) | 20715214 | 2010 Sep 24 |
| The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. | Shukla, Sunita J; Huang, Ruili; Austin, Christopher P; Xia, Menghang | Drug discovery today | 20708096 | 2010 Dec |
| Total syntheses of arylindolizidine alkaloids (+)-ipalbidine and (+)-antofine. | Niphakis, Micah J; Georg, Gunda I | The Journal of organic chemistry | 20704319 | 2010 Sep 3 |
| Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. | Matthew, Susan; Salvador, Lilibeth A; Schupp, Peter J; Paul, Valerie J; Luesch, Hendrik | Journal of natural products | 20704304 | 2010 Sep 24 |
| Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. | Frymoyer, A; Shugarts, S; Browne, M; Wu, A H B; Frassetto, L; Benet, L Z | Clinical pharmacology and therapeutics | 20703222 | 2010 Oct |
| Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. | Tang, M; Wierenga, K; Elsas, L J; Lai, K | Chemico-biological interactions | 20696150 | 2010 Dec 5 |
| Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays. | Horiuchi, Kurumi Y; Ma, Haiching | Methods in molecular biology (Clifton, N.J.) | 20694691 | 2009 |
| Chemical microarrays: a new tool for discovery enzyme inhibitors. | Liang, Shuguang; Xu, Wei; Horiuchi, Kurumi Y; Wang, Yuan; Ma, Haiching | Methods in molecular biology (Clifton, N.J.) | 20694690 | 2009 |
| High-resolution, high-contrast ultrasound imaging using a prototype dual-frequency transducer: in vitro and in vivo studies. | Gessner, Ryan; Lukacs, Marc; Lee, Mike; Cherin, Emmanuel; Foster, F Stuart; Dayton, Paul A | IEEE transactions on ultrasonics, ferroelectrics, and frequency control | 20679006 | 2010 Aug |
| Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis. | Jules, Joel; Ashley, Jason W; Feng, Xu | Expert opinion on therapeutic targets | 20678025 | 2010 Sep |
| Identification of a small molecule inhibitor of importin ýý mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries. | Hintersteiner, Martin; Ambrus, Geza; Bednenko, Janna; Schmied, Mario; Knox, Andrew J S; Meisner, Nicole-Claudia; Gstach, Hubert; Seifert, Jan-Marcus; Singer, Eric L; Gerace, Larry; Auer, Manfred | ACS chemical biology | 20677820 | 2010 Oct 15 |
| Single-cell monitoring using fiberoptic nanosensors. | Vo-Dinh, Tuan; Zhang, Yan | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | 20677238 | 2011 Jan-Feb |
| Plasmonics nanoprobes: detection of single-nucleotide polymorphisms in the breast cancer BRCA1 gene. | Wabuyele, Musundi B; Yan, Fei; Vo-Dinh, Tuan | Analytical and bioanalytical chemistry | 20676618 | 2010 Sep |
| Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. | Zhang, Xiaofei; Bertaso, Federica; Yoo, Jong W; Baumgartel, Karsten; Clancy, Sinead M; Lee, Van; Cienfuegos, Cynthia; Wilmot, Carly; Avis, Jacqueline; Hunyh, Truc; Daguia, Catherine; Schmedt, Christian; Noebels, Jeffrey; Jegla, Timothy | Nature neuroscience | 20676103 | 2010 Sep |
| High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action. | Sergienko, Eduard A; Millan, Jose Luis | Nature protocols | 20671726 | 2010 Aug |
| Structurally characterized luminescent lanthanide zinc carboxylate precursors for Ln-Zn-O nanomaterials. | Boyle, Timothy J; Raymond, Rebecca; Boye, Daniel M; Ottley, Leigh Anna M; Lu, Ping | Dalton transactions (Cambridge, England : 2003) | 20664850 | 2010 Sep 14 |
| Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2. | Dudgeon, Drew D; Shinde, Sunita N; Shun, Tong Ying; Lazo, John S; Strock, Christopher J; Giuliano, Kenneth A; Taylor, D Lansing; Johnston, Patricia A; Johnston, Paul A | Assay and drug development technologies | 20662736 | 2010 Aug |
| An ultra-high throughput cell-based screen for wee1 degradation inhibitors. | Madoux, Franck; Simanski, Scott; Chase, Peter; Mishra, Jitendra K; Roush, William R; Ayad, Nagi G; Hodder, Peter | Journal of biomolecular screening | 20660794 | 2010 Sep |
| In vivo angiogenesis imaging of solid tumors by alpha(v)beta(3)-targeted, dual-modality micellar nanoprobes. | Kessinger, Chase W; Khemtong, Chalermchai; Togao, Osamu; Takahashi, Masaya; Sumer, Baran D; Gao, Jinming | Experimental biology and medicine (Maywood, N.J.) | 20660096 | 2010 Aug |
| Spontaneous formation of temperature-responsive assemblies by molecular recognition of a beta-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide). | Zhang, Jianxiang; Feng, Kai; Cuddihy, Meghan; Kotov, Nicholas A; Ma, Peter X | Soft matter | 20657806 | 2010 Aug 7 |
| Gene expression associations with the growth inhibitory effects of small molecules on live cells: specificity of effects and uniformity of mechanisms. | Shedden, Kerby; Yang, Yang; Rosania, Gus | Statistical analysis and data mining | 20657799 | 2009 Sep 1 |
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| Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. | Judson, Richard S; Martin, Matthew T; Reif, David M; Houck, Keith A; Knudsen, Thomas B; Rotroff, Daniel M; Xia, Menghang; Sakamuru, Srilatha; Huang, Ruili; Shinn, Paul; Austin, Christopher P; Kavlock, Robert J; Dix, David J | Environmental science & technology | 20602530 | 2010 Aug 1 |
| A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist. | Brahimi, Fouad; Liu, Jing; Malakhov, Andrey; Chowdhury, Shafinaz; Purisima, Enrico O; Ivanisevic, Ljubica; Caron, Antoine; Burgess, Kevin; Saragovi, H Uri | Biochimica et biophysica acta | 20600627 | 2010 Sep |
| m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol. | Hall, Michael A; Xi, Jin; Lor, Chong; Dai, Shuiping; Pearce, Robert; Dailey, William P; Eckenhoff, Roderic G | Journal of medicinal chemistry | 20597506 | 2010 Aug 12 |
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| Protein kinase D as a potential new target for cancer therapy. | LaValle, Courtney R; George, Kara M; Sharlow, Elizabeth R; Lazo, John S; Wipf, Peter; Wang, Q Jane | Biochimica et biophysica acta | 20580776 | 2010 Dec |
| A Convenient Synthetic Route to Furan Esters and Lactones by Palladium-Catalyzed Carboalkoxylation or Cyclocarbonylation of Hydroxyl-Substituted 3-Iodofurans. | Cho, Chul-Hee; Larock, Richard C | Tetrahedron letters | 20577579 | 2010 Jun 30 |
| Microwave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy. | Rolfe, Alan; Hanson, Paul R | Tetrahedron letters | 20577568 | 2009 Dec 16 |
| Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology. | Charles, Richelle C; Sheikh, Alaullah; Krastins, Bryan; Harris, Jason B; Bhuiyan, M Saruar; LaRocque, Regina C; Logvinenko, Tanya; Sarracino, David A; Kudva, Indira T; Eisenstein, Jana; Podolsky, Michael J; Kalsy, Anuj; Brooks, W Abdullah; Ludwig, Albrech | Clinical and vaccine immunology : CVI | 20573880 | 2010 Aug |
| In silico binary classification QSAR models based on 4D-fingerprints and MOE descriptors for prediction of hERG blockage. | Su, Bo-Han; Shen, Meng-yu; Esposito, Emilio Xavier; Hopfinger, Anton J; Tseng, Yufeng J | Journal of chemical information and modeling | 20565102 | 2010 Jul 26 |
| Intestinal ferroportin expression in pediatric Crohn's disease. | Burpee, Tyler; Mitchell, Paul; Fishman, Douglas; Islam, Shabana; Nemeth, Elizabeta; Westerman, Mark; Wessling-Resnick, Marianne; Grand, Richard J | Inflammatory bowel diseases | 20564534 | 2011 Feb |
| Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. | Taldone, Tony; Gillan, Victoria; Sun, Weilin; Rodina, Anna; Patel, Pallav; Maitland, Kirsty; O'Neill, Kerry; Chiosis, Gabriela; Devaney, Eileen | PLoS neglected tropical diseases | 20559560 | 2010 |
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| Tandem 6pi-electrocyclization and cycloaddition of nitrodienes to yield multicyclic nitroso acetals. | Creech, Gardner S; Kwon, Ohyun | Journal of the American Chemical Society | 20557050 | 2010 Jul 7 |
| Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. | Chou, Danny Hung-Chieh; Bodycombe, Nicole E; Carrinski, Hyman A; Lewis, Timothy A; Clemons, Paul A; Schreiber, Stuart L; Wagner, Bridget K | ACS chemical biology | 20550176 | 2010 Aug 20 |
| Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. | Blodgett, Joshua A V; Oh, Dong-Chan; Cao, Shugeng; Currie, Cameron R; Kolter, Roberto; Clardy, Jon | Proceedings of the National Academy of Sciences of the United States of America | 20547882 | 2010 Jun 29 |
| Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. | Engel, Juan C; Ang, Kenny K H; Chen, Steven; Arkin, Michelle R; McKerrow, James H; Doyle, Patricia S | Antimicrobial agents and chemotherapy | 20547819 | 2010 Aug |
| An economic framework to prioritize confirmatory tests after a high-throughput screen. | Swamidass, S Joshua; Bittker, Joshua A; Bodycombe, Nicole E; Ryder, Sean P; Clemons, Paul A | Journal of biomolecular screening | 20547534 | 2010 Jul |
| Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. | Kiselyuk, Alice; Farber-Katz, Suzette; Cohen, Tom; Lee, Seung-Hee; Geron, Ifat; Azimi, Behrad; Heynen-Genel, Susanne; Singer, Oded; Price, Jeffrey; Mercola, Mark; Itkin-Ansari, Pamela; Levine, Fred | Journal of biomolecular screening | 20547533 | 2010 Jul |
| Intermolecular C-O addition of carboxylic acids to arynes. | Dubrovskiy, Anton V; Larock, Richard C | Organic letters | 20545313 | 2010 Jul 16 |
| Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities. | Bhave, Gautam; Lonergan, Daniel; Chauder, Brian A; Denton, Jerod S | Future medicinal chemistry | 20543968 | 2010 May |
| Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. | Ferreira, Rafaela S; Simeonov, Anton; Jadhav, Ajit; Eidam, Oliv; Mott, Bryan T; Keiser, Michael J; McKerrow, James H; Maloney, David J; Irwin, John J; Shoichet, Brian K | Journal of medicinal chemistry | 20540517 | 2010 Jul 8 |
| Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists. | Liu, Jing; Brahimi, Fouad; Saragovi, H Uri; Burgess, Kevin | Journal of medicinal chemistry | 20540510 | 2010 Jul 8 |
| PESDserv: a server for high-throughput comparison of protein binding site surfaces. | Das, Sourav; Krein, Michael P; Breneman, Curt M | Bioinformatics (Oxford, England) | 20538727 | 2010 Aug 1 |
| Modulation of bitter taste perception by a small molecule hTAS2R antagonist. | Slack, Jay P; Brockhoff, Anne; Batram, Claudia; Menzel, Susann; Sonnabend, Caroline; Born, Stephan; Galindo, Maria Mercedes; Kohl, Susann; Thalmann, Sophie; Ostopovici-Halip, Liliana; Simons, Christopher T; Ungureanu, Ioana; Duineveld, Kees; Bologa, Crist | Current biology : CB | 20537538 | 2010 Jun 22 |
| Synergistic allelochemicals from a freshwater cyanobacterium. | Leao, Pedro N; Pereira, Alban R; Liu, Wei-Ting; Ng, Julio; Pevzner, Pavel A; Dorrestein, Pieter C; Konig, Gabriele M; Vasconcelos, Vitor M; Gerwick, William H | Proceedings of the National Academy of Sciences of the United States of America | 20534563 | 2010 Jun 22 |
| Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas. | Carpenter, Richard D; Natarajan, Arutselvan; Lau, Edmond Y; Andrei, Mirela; Solano, Danielle M; Lightstone, Felice C; Denardo, Sally J; Lam, Kit S; Kurth, Mark J | Cancer research | 20530664 | 2010 Jul 1 |
| Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs. | Mink, Sheldon R; Vashistha, Surabhi; Zhang, Wenxuan; Hodge, Amanda; Agus, David B; Jain, Anjali | Molecular cancer research : MCR | 20530582 | 2010 Jun |
| Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. | Roman, David L; Blazer, Levi L; Monroy, C Aaron; Neubig, Richard R | Molecular pharmacology | 20530129 | 2010 Sep |
| Syntheses and biological evaluation of ring-C modified colchicine analogs. | Yang, Baiyuan; Zhu, Zhiqing C; Goodson, Holly V; Miller, Marvin J | Bioorganic & medicinal chemistry letters | 20529690 | 2010 Jun 15 |
| Solid-phase synthesis of N-substituted pyrrolidinone-tethered N-substituted piperidines via Ugi reaction. | Liu, Zhang; Nefzi, Adel | Journal of combinatorial chemistry | 20527770 | 2010 Jul 12 |
| Absolute configuration of brevisamide and brevisin: confirmation of a universal biosynthetic process for Karenia brevis polyethers. | Van Wagoner, Ryan M; Satake, Masayuki; Bourdelais, Andrea J; Baden, Daniel G; Wright, Jeffrey L C | Journal of natural products | 20527743 | 2010 Jun 25 |
| Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. | Kontnik, Renee; Crawford, Jason M; Clardy, Jon | ACS chemical biology | 20524642 | 2010 Jul 16 |
| Synthesis of quinazolines from N-(2-nitrophenylsulfonyl)iminodiacetate and alpha-(2-nitrophenylsulfonyl)amino ketones via 2H-indazole 1-oxides. | Krupkova, Sona; Slough, Greg A; Krchnak, Viktor | The Journal of organic chemistry | 20524619 | 2010 Jul 2 |
| Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division. | Christen, Matthias; Kulasekara, Hemantha D; Christen, Beat; Kulasekara, Bridget R; Hoffman, Lucas R; Miller, Samuel I | Science (New York, N.Y.) | 20522779 | 2010 Jun 4 |
| The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. | Zmuda, Erik J; Qi, Ling; Zhu, Michael X; Mirmira, Raghavendra G; Montminy, Marc R; Hai, Tsonwin | Molecular endocrinology (Baltimore, Md.) | 20519332 | 2010 Jul |
| Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. | Book, Adam J; Gladman, Nicholas P; Lee, Sang-Sook; Scalf, Mark; Smith, Lloyd M; Vierstra, Richard D | The Journal of biological chemistry | 20516081 | 2010 Aug 13 |
| A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A. | Brunell, David; Weissbach, Herbert; Hodder, Peter; Brot, Nathan | Assay and drug development technologies | 20515413 | 2010 Oct |
| Structural Characterization of Methanol Substituted Lanthanum Halides. | Boyle, Timothy J; Ottley, Leigh Anna M; Alam, Todd M; Rodriguez, Mark A; Yang, Pin; McIntyre, Sarah K | Polyhedron | 20514349 | 2010 May 10 |
| Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. | Colton, Craig K; Kong, Qiongman; Lai, Liching; Zhu, Michael X; Seyb, Kathleen I; Cuny, Gregory D; Xian, Jun; Glicksman, Marcie A; Lin, Chien-Liang Glenn | Journal of biomolecular screening | 20508255 | 2010 Jul |
| A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging. | Huang, Gang; Zhang, Chunfu; Li, Shunzi; Khemtong, Chalermchai; Yang, Su-Geun; Tian, Ruhai; Minna, John D; Brown, Kathlynn C; Gao, Jinming | Journal of materials chemistry | 20505790 | 2009 |
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| The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. | Berndt, N; Yang, H; Trinczek, B; Betzi, S; Zhang, Z; Wu, B; Lawrence, N J; Pellecchia, M; Schonbrunn, E; Cheng, J Q; Sebti, S M | Cell death and differentiation | 20489726 | 2010 Nov |
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| Advances in molecular imaging with ultrasound. | Gessner, Ryan; Dayton, Paul A | Molecular imaging | 20487678 | 2010 Jun |
| Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents. | Nayak, Tapan K; Dennis, Megan K; Ramesh, Chinnasamy; Burai, Ritwik; Atcher, Robert W; Sklar, Larry A; Norenberg, Jeffrey P; Hathaway, Helen J; Arterburn, Jeffrey B; Prossnitz, Eric R | ACS chemical biology | 20486699 | 2010 Jul 16 |
| Inhibition of protein kinase C-driven nuclear factor-kappaB activation: synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules. | Peddibhotla, Satyamaheshwar; Shi, Ranxin; Khan, Pasha; Smith, Layton H; Mangravita-Novo, Arianna; Vicchiarelli, Michael; Su, Ying; Okolotowicz, Karl J; Cashman, John R; Reed, John C; Roth, Gregory P | Journal of medicinal chemistry | 20481485 | 2010 Jun 24 |
| Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography. | Ralston, Tyler S; Adie, Steven G; Marks, Daniel L; Boppart, Stephen A; Carney, P Scott | Optics letters | 20479849 | 2010 May 15 |
| Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. | Wilson, David M; Keshari, Kayvan R; Larson, Peder E Z; Chen, Albert P; Hu, Simon; Van Criekinge, Mark; Bok, Robert; Nelson, Sarah J; Macdonald, Jeffrey M; Vigneron, Daniel B; Kurhanewicz, John | Journal of magnetic resonance (San Diego, Calif. : 1997) | 20478721 | 2010 Jul |
| A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. | Shah, Parag P; Wang, Tianhua; Kaletsky, Rachel L; Myers, Michael C; Purvis, Jeremy E; Jing, Huiyan; Huryn, Donna M; Greenbaum, Doron C; Smith 3rd, Amos B; Bates, Paul; Diamond, Scott L | Molecular pharmacology | 20466822 | 2010 Aug |
| A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo. | Shi, Q; Nguyen, A T; Angell, Y; Deng, D; Na, C-R; Burgess, K; Roberts, D D; Brunicardi, F C; Templeton, N S | Gene therapy | 20463761 | 2010 Sep |
| A high-throughput screen for chemical inhibitors of exocytic transport in yeast. | Zhang, Lisha; Nebane, N Miranda; Wennerberg, Krister; Li, Yujie; Neubauer, Valerie; Hobrath, Judith V; McKellip, Sara; Rasmussen, Lynn; Shindo, Nice; Sosa, Melinda; Maddry, Joseph A; Ananthan, Subramaniam; Piazza, Gary A; White, E Lucile; Harsay, Edina | Chembiochem : a European journal of chemical biology | 20461743 | 2010 Jun 14 |
| The Skin Cancer Chemotherapeutic Agent Ingenol-3-Angelate (PEP005) Is a Substrate for the Epidermal Multidrug Transporter (ABCB1) and Targets Tumor Vasculature. | Li, Luowei; Shukla, Suneet; Lee, Andrew; Garfield, Susan H; Maloney, David J; Ambudkar, Suresh V; Yuspa, Stuart H | Cancer research | 20460505 | 2010 May 11 |
| Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. | Jiang, Jian-kang; Boxer, Matthew B; Vander Heiden, Matthew G; Shen, Min; Skoumbourdis, Amanda P; Southall, Noel; Veith, Henrike; Leister, William; Austin, Christopher P; Park, Hee Won; Inglese, James; Cantley, Lewis C; Auld, Douglas S; Thomas, Craig J | Bioorganic & medicinal chemistry letters | 20451379 | 2010 Jun 1 |
| Mechanism-based crosslinking as a gauge for functional interaction of modular synthases. | Worthington, Andrew S; Porter, Douglas F; Burkart, Michael D | Organic & biomolecular chemistry | 20449476 | 2010 Apr 21 |
| Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5. | Zhou, Wei; Madrid, Peter; Fluitt, Amy; Stahl, Andreas; Xie, Xinmin Simon | Journal of biomolecular screening | 20448275 | 2010 Jun |
| A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens. | Moshiri, Houtan; Salavati, Reza | Nucleic acids research | 20444864 | 2010 Jul |
| Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. | Wang, Jiangbo; Lu, Jiuyi; Bond, Michael C; Chen, Minyong; Ren, Xiu-Rong; Lyerly, H Kim; Barak, Larry S; Chen, Wei | Proceedings of the National Academy of Sciences of the United States of America | 20439738 | 2010 May 18 |
| Application of kernel functions for accurate similarity search in large chemical databases. | Wang, Xiaohong; Huan, Jun; Smalter, Aaron; Lushington, Gerald H | BMC bioinformatics | 20438655 | 2010 |
| Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. | Liu, Zhuqing; Myers, Michael C; Shah, Parag P; Beavers, Mary Pat; Benedetti, Phillip A; Diamond, Scott L; Smith 3rd, Amos B; Huryn, Donna M | Combinatorial chemistry & high throughput screening | 20438448 | 2010 May |
| Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones. | Donald, Michael B; Conrad, Wayne E; Oakdale, James S; Butler, Jeffrey D; Haddadin, Makhluf J; Kurth, Mark J | Organic letters | 20438102 | 2010 Jun 4 |
| Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. | Chang, Yanqi; Ganesh, Thota; Horton, John R; Spannhoff, Astrid; Liu, Jin; Sun, Aiming; Zhang, Xing; Bedford, Mark T; Shinkai, Yoichi; Snyder, James P; Cheng, Xiaodong | Journal of molecular biology | 20434463 | 2010 Jul 2 |
| D-amino acids trigger biofilm disassembly. | Kolodkin-Gal, Ilana; Romero, Diego; Cao, Shugeng; Clardy, Jon; Kolter, Roberto; Losick, Richard | Science (New York, N.Y.) | 20431016 | 2010 Apr 30 |
| Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. | Uddin, Md Jashim; Crews, Brenda C; Blobaum, Anna L; Kingsley, Philip J; Gorden, D Lee; McIntyre, J Oliver; Matrisian, Lynn M; Subbaramaiah, Kotha; Dannenberg, Andrew J; Piston, David W; Marnett, Lawrence J | Cancer research | 20430759 | 2010 May 1 |
| Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase. | Talukdar, Arindam; Morgunova, Ekaterina; Duan, Jianxin; Meining, Winfried; Foloppe, Nicolas; Nilsson, Lennart; Bacher, Adelbert; Illarionov, Boris; Fischer, Markus; Ladenstein, Rudolf; Cushman, Mark | Bioorganic & medicinal chemistry | 20430628 | 2010 May 15 |
| Regulation of adipogenesis by natural and synthetic REV-ERB ligands. | Kumar, Naresh; Solt, Laura A; Wang, Yongjun; Rogers, Pamela M; Bhattacharyya, Gargi; Kamenecka, Theodore M; Stayrook, Keith R; Crumbley, Christine; Floyd, Z Elizabeth; Gimble, Jeffrey M; Griffin, Patrick R; Burris, Thomas P | Endocrinology | 20427485 | 2010 Jul |
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. | Neumann, Susanne; Huang, Wenwei; Eliseeva, Elena; Titus, Steve; Thomas, Craig J; Gershengorn, Marvin C | Endocrinology | 20427476 | 2010 Jul |
| Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues. | Li, Yangmei; Giulionatti, Marc; Houghten, Richard A | Organic letters | 20426464 | 2010 May 21 |
| Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. | Passer, Brent J; Cheema, Tooba; Zhou, Bingsen; Wakimoto, Hiroaki; Zaupa, Cecile; Razmjoo, Mani; Sarte, Jason; Wu, Shulin; Wu, Chin-lee; Noah, James W; Li, Qianjun; Buolamwini, John K; Yen, Yun; Rabkin, Samuel D; Martuza, Robert L | Cancer research | 20424118 | 2010 May 15 |
| A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells. | Sylvester, Juliesta E; Kron, Stephen J | Molecular cancer therapeutics | 20423990 | 2010 May |
| Hydrophobic pharmaceuticals mediated self-assembly of beta-cyclodextrin containing hydrophilic copolymers: novel chemical responsive nano-vehicles for drug delivery. | Zhang, Jianxiang; Ellsworth, Kristin; Ma, Peter X | Journal of controlled release : official journal of the Controlled Release Society | 20417674 | 2010 Jul 14 |
| Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening. | Li, Ning; Thompson, Scott; Schultz, David C; Zhu, Weiliang; Jiang, Hualiang; Luo, Cheng; Lieberman, Paul M | PloS one | 20405039 | 2010 |
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| Stimuli-responsive SERS nanoparticles: conformational control of plasmonic coupling and surface Raman enhancement. | Qian, Ximei; Li, Jun; Nie, Shuming | Journal of the American Chemical Society | 19453179 | 2009 Jun 10 |
| Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. | Pound, Lynley D; Sarkar, Suparna A; Benninger, Richard K P; Wang, Yingda; Suwanichkul, Adisak; Shadoan, Melanie K; Printz, Richard L; Oeser, James K; Lee, Catherine E; Piston, David W; McGuinness, Owen P; Hutton, John C; Powell, David R; O'Brien, Richard | The Biochemical journal | 19450229 | 2009 Aug 1 |
| Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER. | Prossnitz, Eric R; Barton, Matthias | Prostaglandins & other lipid mediators | 19442754 | 2009 Sep |
| Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. | Bridges, Thomas M; Marlo, Joy E; Niswender, Colleen M; Jones, Carrie K; Jadhav, Satyawan B; Gentry, Patrick R; Plumley, Hyekyung C; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W | Journal of medicinal chemistry | 19438238 | 2009 Jun 11 |
| Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns. | Volchenboum, Samuel L; Kristjansdottir, Kolbrun; Wolfgeher, Donald; Kron, Stephen J | Molecular & cellular proteomics : MCP | 19435713 | 2009 Aug |
| Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography. | Ahmad, Adeel; Adie, Steven G; Chaney, Eric J; Sharma, Utkarsh; Boppart, Stephen A | Optics express | 19434144 | 2009 May 11 |
| Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa. | Meickle, Theresa; Matthew, Susan; Ross, Cliff; Luesch, Hendrik; Paul, Valerie | Planta medica | 19431099 | 2009 Oct |
| In vivo effects of a GPR30 antagonist. | Dennis, Megan K; Burai, Ritwik; Ramesh, Chinnasamy; Petrie, Whitney K; Alcon, Sara N; Nayak, Tapan K; Bologa, Cristian G; Leitao, Andrei; Brailoiu, Eugen; Deliu, Elena; Dun, Nae J; Sklar, Larry A; Hathaway, Helen J; Arterburn, Jeffrey B; Oprea, Tudor I; P | Nature chemical biology | 19430488 | 2009 Jun |
| Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes. | Wang, Hsin-Neng; Vo-Dinh, Tuan | Nanotechnology | 19417369 | 2009 Feb 11 |
| In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. | Lu, Jie; Chan, Lai; Fiji, Hannah D G; Dahl, Russell; Kwon, Ohyun; Tamanoi, Fuyuhiko | Molecular cancer therapeutics | 19417142 | 2009 May |
| Probing marine natural product defenses with DESI-imaging mass spectrometry. | Esquenazi, Eduardo; Dorrestein, Pieter C; Gerwick, William H | Proceedings of the National Academy of Sciences of the United States of America | 19416917 | 2009 May 5 |
| "To learn, you must pay attention." Molecular insights into teachers' wisdom. | Caron, Marc G; Wightman, R Mark | Proceedings of the National Academy of Sciences of the United States of America | 19416916 | 2009 May 5 |
| Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. | Blue, Robert; Kowalska, M Anna; Hirsch, Jessica; Murcia, Marta; Janczak, Christin A; Harrington, Amanda; Jirouskova, Marketa; Li, Jihong; Fuentes, Rudy; Thornton, Michael A; Filizola, Marta; Poncz, Mortimer; Coller, Barry S | Blood | 19414864 | 2009 Jul 2 |
| Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. | Liu, Wei-Ting; Ng, Julio; Meluzzi, Dario; Bandeira, Nuno; Gutierrez, Marcelino; Simmons, Thomas L; Schultz, Andrew W; Linington, Roger G; Moore, Bradley S; Gerwick, William H; Pevzner, Pavel A; Dorrestein, Pieter C | Analytical chemistry | 19413302 | 2009 Jun 1 |
| A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. | Sheffler, Douglas J; Williams, Richard; Bridges, Thomas M; Xiang, Zixiu; Kane, Alexander S; Byun, Nellie E; Jadhav, Satyawan; Mock, Mathew M; Zheng, Fang; Lewis, L Michelle; Jones, Carrie K; Niswender, Colleen M; Weaver, Charles D; Lindsley, Craig W; Conn | Molecular pharmacology | 19407080 | 2009 Aug |
| Application of the "libraries from libraries" concept to "one-bead one-compound" combinatorial chemistry. | Kappel, Joseph C; Fan, Yi C; Lam, Kit S | Advances in experimental medicine and biology | 19400077 | 2009 |
| Effects of drug transporters on volume of distribution. | Grover, Anita; Benet, Leslie Z | The AAPS journal | 19399628 | 2009 Jun |
| Trace amine-associated receptors as emerging therapeutic targets. | Sotnikova, Tatyana D; Caron, Marc G; Gainetdinov, Raul R | Molecular pharmacology | 19389919 | 2009 Aug |
| NAADP mobilizes calcium from acidic organelles through two-pore channels. | Calcraft, Peter J; Ruas, Margarida; Pan, Zui; Cheng, Xiaotong; Arredouani, Abdelilah; Hao, Xuemei; Tang, Jisen; Rietdorf, Katja; Teboul, Lydia; Chuang, Kai-Ting; Lin, Peihui; Xiao, Rui; Wang, Chunbo; Zhu, Yingmin; Lin, Yakang; Wyatt, Christopher N; Parrin | Nature | 19387438 | 2009 May 28 |
| Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. | Zhang, Sharon S; Hao, Ergeng; Yu, Jianxiu; Liu, Wen; Wang, Jing; Levine, Fred; Feng, Gen-Sheng | Proceedings of the National Academy of Sciences of the United States of America | 19380737 | 2009 May 5 |
| Phosphine-promoted [3 + 3] annulations of aziridines with allenoates: facile entry into highly functionalized tetrahydropyridines. | Guo, Hongchao; Xu, Qihai; Kwon, Ohyun | Journal of the American Chemical Society | 19374356 | 2009 May 13 |
| Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua. | Mo, Shunyan; Krunic, Aleksej; Chlipala, George; Orjala, Jimmy | Journal of natural products | 19371071 | 2009 May 22 |
| Design and synthesis of a library of tetracyclic hydroazulenoisoindoles. | Brummond, Kay M; Mao, Shuli; Shinde, Sunita N; Johnston, Paul J; Day, Billy W | Journal of combinatorial chemistry | 19366169 | 2009 May-Jun |
| Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors. | Cai, Lifeng; Balogh, Edina; Gochin, Miriam | Antimicrobial agents and chemotherapy | 19364877 | 2009 Jun |
| Photoconversion in orange and red fluorescent proteins. | Kremers, Gert-Jan; Hazelwood, Kristin L; Murphy, Christopher S; Davidson, Michael W; Piston, David W | Nature methods | 19363494 | 2009 May |
| Polymer-supported alpha-acylamino ketones: preparation and application in syntheses of 1,2,4-trisubstituted-1H-imidazoles. | Koci, Jan; Pudelova, Nadýýzda; Krchnak, Viktor | Journal of combinatorial chemistry | 19354277 | 2009 May-Jun |
| Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots. | Rappoport, Joshua Z; Simon, Sanford M | Journal of cell science | 19351721 | 2009 May 1 |
| Zebrafish genetic models for arrhythmia. | Milan, David J; Macrae, Calum A | Progress in biophysics and molecular biology | 19351520 | 2008 Oct-Nov |
| Rapid and inexpensive fabrication of polymeric microfluidic devices via toner transfer masking. | Easley, Christopher J; Benninger, Richard K P; Shaver, Jesse H; Steven Head, W; Piston, David W | Lab on a chip | 19350094 | 2009 Apr 21 |
| Chapter 2 Correlated light and electron microscopy/electron tomography of mitochondria in situ. | Perkins, Guy A; Sun, Mei G; Frey, Terrence G | Methods in enzymology | 19348881 | 2009 |
| Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects. | Woo, Kyung Mi; Chen, Victor J; Jung, Hong-Moon; Kim, Tae-Il; Shin, Hong-In; Baek, Jeong-Hwa; Ryoo, Hyun-Mo; Ma, Peter X | Tissue engineering. Part A | 19348597 | 2009 Aug |
| High-throughput real-time PCR for detection of gene-expression levels. | Wagner, Bridget K; Arany, Zoltan | Methods in molecular biology (Clifton, N.J.) | 19347623 | 2009 |
| High-content screening: flow cytometry analysis. | Edwards, Bruce S; Young, Susan M; Ivnitsky-Steele, Irena; Ye, Richard D; Prossnitz, Eric R; Sklar, Larry A | Methods in molecular biology (Clifton, N.J.) | 19347622 | 2009 |
| Assay for isolation of inhibitors of her2-kinase expression. | Chiosis, Gabriela; Keeton, Adam B | Methods in molecular biology (Clifton, N.J.) | 19347621 | 2009 |
| Cell-based assays to probe the ERK MAP kinase pathway in endothelial cells. | Wyler, Michael R; Smith, Deborah H; Cayanis, Eftihia; Tobben, Udo; Aulner, Nathalie; Mayer, Thomas | Methods in molecular biology (Clifton, N.J.) | 19347614 | 2009 |
| A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans. | Pungaliya, Chirag; Srinivasan, Jagan; Fox, Bennett W; Malik, Rabia U; Ludewig, Andreas H; Sternberg, Paul W; Schroeder, Frank C | Proceedings of the National Academy of Sciences of the United States of America | 19346493 | 2009 May 12 |
| Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. | Hur, Gene H; Meier, Jordan L; Baskin, Jeremy; Codelli, Julian A; Bertozzi, Carolyn R; Marahiel, Mohamed A; Burkart, Michael D | Chemistry & biology | 19345117 | 2009 Apr 24 |
| Fuel specificity of the hepatitis C virus NS3 helicase. | Belon, Craig A; Frick, David N | Journal of molecular biology | 19332076 | 2009 May 15 |
| Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. | Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R; Clardy, Jon | Nature chemical biology | 19330011 | 2009 Jun |
| Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. | Bachovchin, Daniel A; Brown, Steven J; Rosen, Hugh; Cravatt, Benjamin F | Nature biotechnology | 19329999 | 2009 Apr |
| Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. | Chu, Wenhua; Rothfuss, Justin; Chu, Yunxiang; Zhou, Dong; Mach, Robert H | Journal of medicinal chemistry | 19326941 | 2009 Apr 23 |
| Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines. | Tardibono, Lawrence P; Miller, Marvin J | Organic letters | 19320504 | 2009 Apr 2 |
| Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists. | Doghman, Mabrouka; Cazareth, Julie; Douguet, Dominique; Madoux, Franck; Hodder, Peter; Lalli, Enzo | The Journal of clinical endocrinology and metabolism | 19318454 | 2009 Jun |
| Synthesis of a cross-linked branched polymer network in the interior of a protein cage. | Abedin, Md Joynal; Liepold, Lars; Suci, Peter; Young, Mark; Douglas, Trevor | Journal of the American Chemical Society | 19317506 | 2009 Apr 1 |
| Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. | Patel, Vishal; Mazitschek, Ralph; Coleman, Bradley; Nguyen, Cokey; Urgaonkar, Sameer; Cortese, Joseph; Barker, Robert H; Greenberg, Edward; Tang, Weiping; Bradner, James E; Schreiber, Stuart L; Duraisingh, Manoj T; Wirth, Dyann F; Clardy, Jon | Journal of medicinal chemistry | 19317450 | 2009 Apr 23 |
| In vivo modification of native carrier protein domains. | Mercer, Andrew C; Meier, Jordan L; Torpey, Justin W; Burkart, Michael D | Chembiochem : a European journal of chemical biology | 19308927 | 2009 Apr 17 |
| The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons. | Geng, Yang; Hoke, Ahmet; Delpire, Eric | The Journal of biological chemistry | 19307180 | 2009 May 22 |
| Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. | Xie, Yuli; Liu, Yidong; Gong, Gangli; Smith, Deborah H; Yan, Fang; Rinderspacher, Alison; Feng, Yan; Zhu, Zhengxiang; Li, Xiangpo; Deng, Shi-Xian; Branden, Lars; Vidovic, Dusica; Chung, Caty; Schurer, Stephan; Morisseau, Christophe; Hammock, Bruce D; Land | Bioorganic & medicinal chemistry letters | 19303288 | 2009 Apr 15 |
| [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98. | Zhou, Dong; Chu, Wenhua; Chen, Delphine L; Wang, Qi; Reichert, David E; Rothfuss, Justin; D'Avignon, Andre; Welch, Michael J; Mach, Robert H | Organic & biomolecular chemistry | 19300818 | 2009 Apr 7 |
| Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules. | Marsolais, David; Rosen, Hugh | Nature reviews. Drug discovery | 19300460 | 2009 Apr |
| Using biological performance similarity to inform disaccharide library design. | Tanikawa, Tetsuya; Fridman, Micha; Zhu, Wenjiang; Faulk, Brian; Joseph, Isaac C; Kahne, Daniel; Wagner, Bridget K; Clemons, Paul A | Journal of the American Chemical Society | 19298063 | 2009 Apr 15 |
| Nanohole arrays of mixed designs and microwriting for simultaneous and multiple protein binding studies. | Ji, Jin; Yang, Jiun-Chan; Larson, Dale N | Biosensors & bioelectronics | 19297143 | 2009 May 15 |
| Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors. | Andrade, Carolina H; Pasqualoto, Kerly F M; Ferreira, Elizabeth I; Hopfinger, Anton J | Journal of chemical information and modeling | 19296716 | 2009 Apr |
| Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways. | Li, Xiaohai; He, Yuanjun; Ruiz, Claudia H; Koenig, Marcel; Cameron, Michael D; Vojkovsky, Tomas | Drug metabolism and disposition: the biological fate of chemicals | 19282395 | 2009 Jun |
| Hairpin str |