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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Authors Journal PubMedID Publication Date PubMedLink
A Novel Inhibitor of Alpha- Galactosidase Identified from a Compound Library Screen Motabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng W Current Chemical Genomics 999999929 2010 https://www.ncbi.nlm.nih.gov/pubmed/999999929
Fluorescence polarization assays in small molecule screening Lea, W. L., and Simeonov, A. Expert Op Drug Disc 999999928 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999928
The Ups and Downs of Structure-Activity Landscapes Guha R. Methods Mol Biol. 999999927 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999927
The Ups and Downs of Structure-Activity Landscapes Guha R. Cheminformatics and Computational Chemical Biology 999999926 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999926
Understanding Enzymes as Reporters or Targets in Assays Using Quantitative High-Throughput Screening (qHTS) Auld DS, Thorne N, Boxer MB, Southall N, Shen M, Thomas CJ, Inglese J 4th International ESCEC Symposium on Experimental Standard Conditions of Enzyme Characterizations 999999925 2010 https://www.ncbi.nlm.nih.gov/pubmed/999999925
Identification and validation of clinically utilized drugs for the treatment of adrenocortical cancer Nilubol N, Zhang L, Shen M, Zhang Y-Q, He M, Kebebew E Endocrine-Related Cancer 999999924 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999924
Interplay between Tdp1, CtIP and PARP for the Repair of Topoisomerase I and II-induced DNA Damage in Vertebrate Cells Murai J, Huang S-Y N, Das BB, Dexheimer TS, Takeda S, Pommier Y PloS Genetics 999999923 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999923
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase Morgan HP, Walsh M, Boxer M, Shen M, Blackburn EA, Wear MA, McNae IW, Nowicki MW, Michels P A-M, Auld DS, Fothergill-Gilmore LA & Walkinshaw MD J. Biological Chemistry 999999922 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999922
NRG1-ErbB4-p110δ signaling in schizophrenia. Reversal of amphetamine-induced behaviors by selective p110δ inhibition Law AJ, Wang Y, Sei Y, Papaleo F, Huang W, Thomas CJ, Austin CP, Harrison PJ, Lipska BK, Hyde TM, Kleinman JE, Weinberger DR Proc Natl Acad Sci USA 999999921 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999921
Physiopathological role of the Neuropeptide S system in cocaine relapse: A mechanism mediated by the hypothalamic hypocretin system Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R Proc Natl Acad Sci USA 999999920 2010 https://www.ncbi.nlm.nih.gov/pubmed/999999920
Computational approaches in cheminformatics and bioinformatics Guha R, Bender A. 1st ed Hoboken 999999919 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999919
Exploring Structure-activity-relationships to design novel drugs Guha, R. Silico Models for Drug Discovery 999999918 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999918
Selecting, acquiring and using small molecule libraries for high-throughput screening Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ Curr. Prot. Chem. Biol. 999999917 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999917
A High Affinity αIIbβ3 Antagonist Displays a Novel Mechanism of Inhibiting Ligand Binding, Competing with Mg2+ for Interacting with the MIDAS Glu220 Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Zhu J, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS Nat. Struct. Mol. Biol. 999999916 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999916
Molecular Sensors for Transcriptional and Post-Transcriptional Assays Auld DS & Thorne N Chemical Genomics 999999915 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999915
Urotensin-II Receptor Antagonists: From Peptides to Small-Molecules. Assessment of Potency, Selectivity, and In Vitro ADME Properties Luci D, Maloney D Diane Luci: ACS 999999914 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999914
Chapter 16. Tyrosyl DNA-phosphodiesterase Dexheimer TS, Huang S-YN, Das BB, Pommier Y DNA Topoisomerases and Cancer. Cancer Drug Discovery and Development 999999913 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999913
Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New Bioactive Compounds Benson SC, Lee L, Wei W, Ni F, Olmos JDJ, Strom KR, Beeler AB, Cheng KC-C, Inglese J, Kota S, Takahashi V, Strosberg AD, Connor JH, Bushkin GG, Snyder JK Heterocycles 999999912 2011 https://www.ncbi.nlm.nih.gov/pubmed/999999912
On Exploring Structure Activity Relationships Guha R Silico Models for Drug Discovery 999999911 2013 https://www.ncbi.nlm.nih.gov/pubmed/999999911
Decreased Subcutaneous Bioavailability of an Oxyntomodulin Analog in a Controlled Release Formulation could be Caused by Skin Metabolism in Rats Wang M, Defranco D, Wright K, Quazi S, Chen J, Spencer-Pierce J, Zaghloul I, Pak R, Darvari R, Krishnan A, Perreault M, Sun L, Ozer J, O’Hara D, Rup B, and Xu X J Bioequiv Availab 999999910 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999910
Perspectives and Challenges in Epigenetic Therapy: DNA Methylation in Cancer Stem Cells. Book Chapter in: DNA Methylation: Principles, Mechanisms and Challenges Sun L, Yang A, Cabarcas SM, Mathews LA, Farrar W Nova Science Publisher 999999909 2013 https://www.ncbi.nlm.nih.gov/pubmed/999999909
Pharmaceutical Profiling Case Study in Disruption Kerns, EH. ACS Med Chem Lett 999999908 2013 https://www.ncbi.nlm.nih.gov/pubmed/999999908
CD28-ITK signals regulate autoreactive T cell trafficking into tissues Jain M, Jiang J-k, Greiner D, Thomas CJ, Berg LJ, Kang J The Journal of Immunology 999999907 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999907
Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP Johnson RL, Huang W Littman DR ACS Med Chem Lett. 999999906 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999906
Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources Guha R, Nguyen D-T, Southall N, Jadhav A Current Protocols in Chemical Biology 999999905 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999905
Exploring Structure-Activity Data Using the Landscape Paradigm Guha WIREs Comput Mol Sci, 2 999999904 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999904
Reply to Kojo: Mechanisms of antioxidant-induced DNA damage Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K Proc Natl Acad Sci USA 999999903 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999903
Selecting, acquiring and using small molecule libraries for high-throughput screening Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ Current Protocols in Chemical Biology 999999902 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999902
Toxicity testing with Heparg spheroids Auld DS, Lea W, Davis MI, Simeonov A ASSAY and Drug Development Technologies 999999901 2012 https://www.ncbi.nlm.nih.gov/pubmed/999999901
A proteomics landscape of circadian clock in mouse liver. Wang, Yunzhi; Song, Lei; Liu, Mingwei; Ge, Rui; Zhou, Quan; Liu, Wanlin; Li, Ruiyang; Qie, Jingbo; Zhen, Bei; Wang, Yi; He, Fuchu; Qin, Jun; Ding, Chen Nature communications. 29674717 2018 Apr 19; https://www.ncbi.nlm.nih.gov/pubmed/29674717
Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition. Koplev, Simon; Lin, Katie; Dohlman, Anders B; Ma'ayan, Avi PLoS computational biology. 29293502 2018 01; https://www.ncbi.nlm.nih.gov/pubmed/29293502
D4dopamine receptor high-resolution structures enable the discovery of selective agonists. Wang, Sheng; Wacker, Daniel; Levit, Anat; Che, Tao; Betz, Robin M; McCorvy, John D; Venkatakrishnan, A J; Huang, Xi-Ping; Dror, Ron O; Shoichet, Brian K; Roth, Bryan L Science (New York, N.Y.). 29051383 2017 10 20; https://www.ncbi.nlm.nih.gov/pubmed/29051383
Systems Medicine Approaches to Improving Understanding, Treatment, and Clinical Management of Neuroendocrine Prostate Cancer. Yadav, Kamlesh K; Shameer, Khader; Readhead, Ben; Yadav, Shalini S; Li, Li; Kasarskis, Andrew; Tewari, Ashutosh K; Dudley, Joel T Current pharmaceutical design. 27174811 2016; https://www.ncbi.nlm.nih.gov/pubmed/27174811
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Vardy, Eyal; Sassano, Maria F; Rennekamp, Andrew J; Kroeze, Wesley K; Mosier, Philip D; Westkaemper, Richard B; Stevens, Craig W; Katritch, Vsevolod; Stevens, Raymond C; Peterson, Randall T; Roth, Bryan L Chemistry & biology. 26091169 2015 Jun 18; https://www.ncbi.nlm.nih.gov/pubmed/26091169
Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors. Tsai, Yihsuan S; Dominguez, Daniel; Gomez, Shawn M; Wang, Zefeng Oncotarget. 25749525 2015 Mar 30; https://www.ncbi.nlm.nih.gov/pubmed/25749525
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. Duarte, Luis F; Young, Andrew R J; Wang, Zichen; Wu, Hsan-Au; Panda, Taniya; Kou, Yan; Kapoor, Avnish; Hasson, Dan; Mills, Nicholas R; Ma'ayan, Avi; Narita, Masashi; Bernstein, Emily Nature communications. 25394905 2014; https://www.ncbi.nlm.nih.gov/pubmed/25394905
A blueprint of cell identity. Ma'ayan, Avi; Duan, Qiaonan Nature biotechnology. 25299921 2014 Oct; https://www.ncbi.nlm.nih.gov/pubmed/25299921
Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment. Petrukhin, Konstantin Drug discovery today. Therapeutic strategies 25152755 2013 https://www.ncbi.nlm.nih.gov/pubmed/25152755
Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification. Sahn, James J; Granger, Brett A; Martin, Stephen F Organic & biomolecular chemistry 25135846 2014 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/25135846
Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes. Yu, Yi-Yun; Georg, Gunda I Advanced synthesis & catalysis 25071423 2014 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/25071423
A high throughput flow cytometric assay platform targeting transporter inhibition. Tegos, George P; Evangelisti, Annette M; Strouse, J Jacob; Ursu, Oleg; Bologa, Cristian; Sklar, Larry A Drug discovery today. Technologies 25027381 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/25027381
Synthesis of the rosette-inducing factor RIF-1 and analogs. Beemelmanns, Christine; Woznica, Arielle; Alegado, Rosanna A; Cantley, Alexandra M; King, Nicole; Clardy, Jon Journal of the American Chemical Society 24983513 2014 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/24983513
Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis. Goller, Carlos C; Arshad, Mehreen; Noah, James W; Ananthan, Subramaniam; Evans, Carrie W; Nebane, N Miranda; Rasmussen, Lynn; Sosa, Melinda; Tower, Nichole A; White, E Lucile; Neuenswander, Benjamin; Porubsky, Patrick; Maki, Brooks E; Rogers, Steven A; Sc PloS one 24983234 2014 https://www.ncbi.nlm.nih.gov/pubmed/24983234
Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons. Parks, Gregory S; Wang, Lien; Wang, Zhiwei; Civelli, Olivier The Journal of comparative neurology 24978951 2014 Jun 30 https://www.ncbi.nlm.nih.gov/pubmed/24978951
Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process. Medda, Federico; Hulme, Christopher Tetrahedron letters 24954960 2014 May 1 https://www.ncbi.nlm.nih.gov/pubmed/24954960
Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. Sully, Erin K; Malachowa, Natalia; Elmore, Bradley O; Alexander, Susan M; Femling, Jon K; Gray, Brian M; DeLeo, Frank R; Otto, Michael; Cheung, Ambrose L; Edwards, Bruce S; Sklar, Larry A; Horswill, Alexander R; Hall, Pamela R; Gresham, Hattie D PLoS pathogens 24945495 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24945495
Novel succinct routes to Quinoxalines and 2-Benzimidazolylquinoxalines via the Ugi reaction. Ayaz, Muhammad; Xu, Zhigang; Hulme, Christopher Tetrahedron letters 24932052 2014 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/24932052
Enzyme inhibitor discovery by activity-based protein profiling. Niphakis, Micah J; Cravatt, Benjamin F Annual review of biochemistry 24905785 2014 https://www.ncbi.nlm.nih.gov/pubmed/24905785
Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. Du, Lin; Robles, Andrew J; King, Jarrod B; Mooberry, Susan L; Cichewicz, Robert H Journal of natural products 24893224 2014 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/24893224
Thielavialides A-E, nor-spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, an endophytic fungus isolated from aeroponically grown Physalis alkekengi. Wijeratne, E M Kithsiri; Espinosa-Artiles, Patricia; Gruener, Raphael; Gunatilaka, A A Leslie Journal of natural products 24882589 2014 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/24882589
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. Chou, Tsui-Fen; Bulfer, Stacie L; Weihl, Conrad C; Li, Kelin; Lis, Lev G; Walters, Michael A; Schoenen, Frank J; Lin, Henry J; Deshaies, Raymond J; Arkin, Michelle R Journal of molecular biology 24878061 2014 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/24878061
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor. Conn, P Michael; Smith, Emery; Spicer, Timothy; Chase, Peter; Scampavia, Louis; Janovick, Jo Ann Assay and drug development technologies 24831790 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24831790
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sun, Haiyan; Wei, Ying; Deng, Huayun; Xiong, Qiaojie; Li, Min; Lahiri, Joydeep; Fang, Ye Scientific reports 24816792 2014 https://www.ncbi.nlm.nih.gov/pubmed/24816792
Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. Low, Yen Sia; Sedykh, Alexander Yeugenyevich; Rusyn, Ivan; Tropsha, Alexander Current topics in medicinal chemistry 24805064 2014 https://www.ncbi.nlm.nih.gov/pubmed/24805064
Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs. Wenthur, Cody J; Morrison, Ryan D; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W Bioorganic & medicinal chemistry letters 24794112 2014 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/24794112
Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella. Kwan, Jason C; Tianero, Ma Diarey B; Donia, Mohamed S; Wyche, Thomas P; Bugni, Tim S; Schmidt, Eric W PloS one 24788869 2014 https://www.ncbi.nlm.nih.gov/pubmed/24788869
Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions. Martinez-Ariza, Guillermo; Ayaz, Muhammad; Medda, Federico; Hulme, Christopher The Journal of organic chemistry 24788091 2014 Jun 6 https://www.ncbi.nlm.nih.gov/pubmed/24788091
Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2H)-ones and 2,3-dihydropyridin-4(1H)-ones from *-substituted *-hydroxyaminoaldehydes. Ranade, Adwait R; Georg, Gunda I The Journal of organic chemistry 24785413 2014 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/24785413
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. Abulwerdi, Fardokht A; Liao, Chenzhong; Mady, Ahmed S; Gavin, Jordan; Shen, Chenxi; Cierpicki, Tomasz; Stuckey, Jeanne A; Showalter, H D Hollis; Nikolovska-Coleska, Zaneta Journal of medicinal chemistry 24749893 2014 May 22 https://www.ncbi.nlm.nih.gov/pubmed/24749893
Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. Yan, Fei; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; O'Malley, Bert W; Lonard, David M PloS one 24743578 2014 https://www.ncbi.nlm.nih.gov/pubmed/24743578
Protein chaperones: a composition of matter review (2008 - 2013). Taldone, Tony; Patel, Hardik J; Bolaender, Alexander; Patel, Maulik R; Chiosis, Gabriela Expert opinion on therapeutic patents 24742089 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24742089
Solvent-dependent divergent functions of Sc(OTf)ýýý in stereoselective epoxide-opening spiroketalizations. Sharma, Indrajeet; Wurst, Jacqueline M; Tan, Derek S Organic letters 24742081 2014 May 2 https://www.ncbi.nlm.nih.gov/pubmed/24742081
Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth. Sarkisyan, Gor; Gay, Laurie J; Nguyen, Nhan; Felding, Brunhilde H; Rosen, Hugh American journal of physiology. Cell physiology 24740542 2014 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/24740542
Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. Oldstone, Michael B A; Rosen, Hugh Current topics in microbiology and immunology 24728596 2014 https://www.ncbi.nlm.nih.gov/pubmed/24728596
Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics. Swale, Daniel R; Kharade, Sujay V; Denton, Jerod S Current opinion in pharmacology 24721648 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24721648
Evaluation of prostate-specific membrane antigen as an imaging reporter. Castanares, Mark A; Mukherjee, Amarnath; Chowdhury, Wasim H; Liu, Minzhi; Chen, Ying; Mease, Ronnie C; Wang, Yuchuan; Rodriguez, Ronald; Lupold, Shawn E; Pomper, Martin G Journal of nuclear medicine : official publication, Society of Nuclear Medicine 24700883 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24700883
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5 -Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe. Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P Jef ChemMedChem 24692176 2014 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/24692176
Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. Gavrish, Ekaterina; Sit, Clarissa S; Cao, Shugeng; Kandror, Olga; Spoering, Amy; Peoples, Aaron; Ling, Losee; Fetterman, Ashley; Hughes, Dallas; Bissell, Anthony; Torrey, Heather; Akopian, Tatos; Mueller, Andreas; Epstein, Slava; Goldberg, Alfred; Clardy, Chemistry & biology 24684906 2014 Apr 24 https://www.ncbi.nlm.nih.gov/pubmed/24684906
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. Rai, Ganesha; Joshi, Netra; Jung, Joo Eun; Liu, Yu; Schultz, Lena; Yasgar, Adam; Perry, Steve; Diaz, Giovanni; Zhang, Qiangli; Kenyon, Victor; Jadhav, Ajit; Simeonov, Anton; Lo, Eng H; van Leyen, Klaus; Maloney, David J; Holman, Theodore R Journal of medicinal chemistry 24684213 2014 May 22 https://www.ncbi.nlm.nih.gov/pubmed/24684213
Protein phosphatases in pancreatic islets. Ortsater, Henrik; Grankvist, Nina; Honkanen, Richard E; Sjoholm, Ake The Journal of endocrinology 24681827 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24681827
Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. Walsh, Kevin B; Teijaro, John R; Brock, Linda G; Fremgen, Daniel M; Collins, Peter L; Rosen, Hugh; Oldstone, Michael B A Journal of virology 24672024 2014 Jun https://www.ncbi.nlm.nih.gov/pubmed/24672024
The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions. Prohaska, Kimberly M; Bennett, Ryan P; Salter, Jason D; Smith, Harold C Wiley interdisciplinary reviews. RNA 24664896 2014 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/24664896
Synthesis of novel peptidyl adenosine antibiotic analogs. Moukha-Chafiq, Omar; Reynolds, Robert C Nucleosides, nucleotides & nucleic acids 24660880 2014 https://www.ncbi.nlm.nih.gov/pubmed/24660880
Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis. Kim, Yong Wook; Georg, Gunda I Organic letters 24650204 2014 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/24650204
In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4. Mandal, Nawajes A; Tran, Julie-Thu A; Zheng, Lixin; Wilkerson, Joseph L; Brush, Richard S; McRae, Joel; Agbaga, Martin-Paul; Zhang, Kang; Petrukhin, Konstantin; Ayyagari, Radha; Anderson, Robert E Investigative ophthalmology & visual science 24644051 2014 Apr https://www.ncbi.nlm.nih.gov/pubmed/24644051
A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence. Vekariya, Rakesh H; Liu, Ruzhang; Aube, Jeffrey Organic letters 24635056 2014 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/24635056
Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives. Pagano, Nicholas; Heil, Marintha L; Cosford, Nicholas D P Synthesis 24634547 2012 https://www.ncbi.nlm.nih.gov/pubmed/24634547
Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Yuan, Hsiangkuo; Wilson, Christy M; Xia, Jun; Doyle, Sarah L; Li, Shuqin; Fales, Andrew M; Liu, Yang; Ozaki, Ema; Mulfaul, Kelly; Hanna, Gabi; Palmer, Gregory M; Wang, Lihong V; Grant, Gerald A; Vo-Dinh, Tuan Nanoscale 24619405 2014 Apr 21 https://www.ncbi.nlm.nih.gov/pubmed/24619405
Equilibrium and kinetics of Sin Nombre hantavirus binding at DAF/CD55 functionalized bead surfaces. Buranda, Tione; Swanson, Scarlett; Bondu, Virginie; Schaefer, Leah; Maclean, James; Mo, Zhenzhen; Wycoff, Keith; Belle, Archana; Hjelle, Brian Viruses 24618810 2014 https://www.ncbi.nlm.nih.gov/pubmed/24618810
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Ziemert, Nadine; Lechner, Anna; Wietz, Matthias; Millan-Aguinaga, Natalie; Chavarria, Krystle L; Jensen, Paul Robert Proceedings of the National Academy of Sciences of the United States of America 24616526 2014 Mar 25 https://www.ncbi.nlm.nih.gov/pubmed/24616526
A chimeric siderophore halts swarming Vibrio. Bottcher, Thomas; Clardy, Jon Angewandte Chemie (International ed. in English) 24615751 2014 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/24615751
Discovery of ML314, a Brain Penetrant Non-Peptidic *-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Maloney, Patrick R; Li, Yujie; Milewski, Monika; Gosalia, Palak; Gray, Wilson; Mehta, Alka; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Heynen-Genel, Susanne; Vasile, Stefa ACS medicinal chemistry letters 24611085 2013 Jul 20 https://www.ncbi.nlm.nih.gov/pubmed/24611085
Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy. Teijaro, John R; Walsh, Kevin B; Long, James P; Tordoff, Kevin P; Stark, Gregory V; Eisfeld, Amie J; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B A Virology 24606692 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24606692
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors. Brahimi, Fouad; Ko, Eunhwa; Malakhov, Andrey; Burgess, Kevin; Saragovi, H Uri PloS one 24603864 2014 https://www.ncbi.nlm.nih.gov/pubmed/24603864
Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Kwan, Jason C; Liu, Yanxia; Ratnayake, Ranjala; Hatano, Ryo; Kuribara, Akiko; Morimoto, Chiko; Ohnuma, Kei; Paul, Valerie J; Ye, Tao; Luesch, Hendrik Chembiochem : a European journal of chemical biology 24591193 2014 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/24591193
Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor ýý is therapeutic in the collagen-induced arthritis experimental model. Chang, Mi Ra; Lyda, Brent; Kamenecka, Theodore M; Griffin, Patrick R Arthritis & rheumatology (Hoboken, N.J.) 24574218 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24574218
Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Gonzalez, David J; Vuong, Lisa; Gonzalez, Isaiah S; Keller, Nadia; McGrosso, Dominic; Hwang, John H; Hung, Jun; Zinkernagel, Annelies; Dixon, Jack E; Dorrestein, Pieter C; Nizet, Victor Molecular & cellular proteomics : MCP 24567418 2014 May https://www.ncbi.nlm.nih.gov/pubmed/24567418
Diastereoselective synthesis of ýý- and ýý-lactams from imines and sulfone-substituted anhydrides. Sorto, Nohemy A; Di Maso, Michael J; Munoz, Manuel A; Dougherty, Ryan J; Fettinger, James C; Shaw, Jared T The Journal of organic chemistry 24552208 2014 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/24552208
MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines. Bell, Christan E; Shaw, Arthur Y; De Moliner, Fabio; Hulme, Christopher Tetrahedron 24535889 2014 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/24535889
Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp. Ellis, Gregory A; Wyche, Thomas P; Fry, Charles G; Braun, Doug R; Bugni, Tim S Marine drugs 24534844 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24534844
Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site. Gregory, Karen J; Nguyen, Elizabeth D; Malosh, Chrysa; Mendenhall, Jeffrey L; Zic, Jessica Z; Bates, Brittney S; Noetzel, Meredith J; Squire, Emma F; Turner, Eric M; Rook, Jerri M; Emmitte, Kyle A; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn, ACS chemical neuroscience 24528109 2014 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/24528109
M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses. Pancani, Tristano; Bolarinwa, Caroline; Smith, Yoland; Lindsley, Craig W; Conn, P Jeffrey; Xiang, Zixiu ACS chemical neuroscience 24528004 2014 Apr 16 https://www.ncbi.nlm.nih.gov/pubmed/24528004
Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. Bandyopadhyay, Sanghamitra; Rogers, Jack T Biochemical pharmacology 24513321 2014 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/24513321
Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor. Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry A Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 24510772 2014 https://www.ncbi.nlm.nih.gov/pubmed/24510772
Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor. Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry A Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 24510772 2014 https://www.ncbi.nlm.nih.gov/pubmed/24510772
Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Xie, Pengfei; Ma, Ming; Rateb, Mostafa E; Shaaban, Khaled A; Yu, Zhiguo; Huang, Sheng-Xiong; Zhao, Li-Xing; Zhu, Xiangcheng; Yan, Yijun; Peterson, Ryan M; Lohman, Jeremy R; Yang, Dong; Yin, Min; Rudolf, Jeffrey D; Jiang, Yi; Duan, Yanwen; Shen, Ben Journal of natural products 24484381 2014 Feb 28 https://www.ncbi.nlm.nih.gov/pubmed/24484381
Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. Neochoritis, Constantinos G; Domling, Alexander Organic & biomolecular chemistry 24477767 2014 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/24477767
Programmed death-1: therapeutic success after more than 100ýýýyears of cancer immunotherapy. Domling, Alexander; Holak, Tad A Angewandte Chemie (International ed. in English) 24474145 2014 Feb 24 https://www.ncbi.nlm.nih.gov/pubmed/24474145
Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. Fan, Longchang; Guan, Xiaowei; Wang, Wei; Zhao, Jian-Yuan; Zhang, Hongkang; Tiwari, Vinod; Hoffman, Paul N; Li, Min; Tao, Yuan-Xiang Molecular pain 24472174 2014 https://www.ncbi.nlm.nih.gov/pubmed/24472174
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. He, Shihan; Senter, Timothy J; Pollock, Jonathan; Han, Changho; Upadhyay, Sunil Kumar; Purohit, Trupta; Gogliotti, Rocco D; Lindsley, Craig W; Cierpicki, Tomasz; Stauffer, Shaun R; Grembecka, Jolanta Journal of medicinal chemistry 24472025 2014 Feb 27 https://www.ncbi.nlm.nih.gov/pubmed/24472025
Chemo- and site-selective derivatizations of natural products enabling biological studies. Robles, Omar; Romo, Daniel Natural product reports 24468713 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24468713
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. Gao, Wei; Sun, Hai-Xi; Xiao, Hongbin; Cui, Guanghong; Hillwig, Matthew L; Jackson, Alana; Wang, Xiao; Shen, Ye; Zhao, Nan; Zhang, Liangxiao; Wang, Xiu-Jie; Peters, Reuben J; Huang, Luqi BMC genomics 24467826 2014 https://www.ncbi.nlm.nih.gov/pubmed/24467826
A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. Lewallen, Daniel M; Bicker, Kevin L; Madoux, Franck; Chase, Peter; Anguish, Lynne; Coonrod, Scott; Hodder, Peter; Thompson, Paul R ACS chemical biology 24467619 2014 Apr 18 https://www.ncbi.nlm.nih.gov/pubmed/24467619
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. Sheffler, Douglas J; Nedelovych, Michael T; Williams, Richard; Turner, Stephen C; Duerk, Brittany B; Robbins, Megan R; Jadhav, Sataya B; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Daniels, R Nathan; Lindsley, Craig W Bioorganic & medicinal chemistry letters 24462664 2014 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/24462664
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. Jones, Carrie K; Sheffler, Douglas J; Williams, Richard; Jadhav, Sataya B; Felts, Andrew S; Morrison, Ryan D; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W Bioorganic & medicinal chemistry letters 24461352 2014 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/24461352
A novel class of ion displacement ligands as antagonists of the *IIb*3 receptor that limit conformational reorganization of the receptor. Jiang, Jian-kang; McCoy, Joshua G; Shen, Min; LeClair, Christopher A; Huang, Wenwei; Negri, Ana; Li, Jihong; Blue, Robert; Harrington, Amanda Weil; Naini, Sarasija; David 3rd, George; Choi, Won-Seok; Volpi, Elisabetta; Fernandez, Joseph; Babayeva, Mariana Bioorganic & medicinal chemistry letters 24461295 2014 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/24461295
Probing chemical space with alkaloid-inspired libraries. McLeod, Michael C; Singh, Gurpreet; Plampin 3rd, James N; Rane, Digamber; Wang, Jenna L; Day, Victor W; Aube, Jeffrey Nature chemistry 24451589 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24451589
Chemical modulation of glycerolipid signaling and metabolic pathways. Scott, Sarah A; Mathews, Thomas P; Ivanova, Pavlina T; Lindsley, Craig W; Brown, H Alex Biochimica et biophysica acta 24440821 2014 Jan 15 https://www.ncbi.nlm.nih.gov/pubmed/24440821
Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Dreyton, Christina J; Anderson, Erin D; Subramanian, Venkataraman; Boger, Dale L; Thompson, Paul R Bioorganic & medicinal chemistry 24440480 2014 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/24440480
Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model. Aldrich, Leslie N; Berry, Cynthia B; Bates, Brittney S; Konkol, Leah C; So, Miranda; Lindsley, Craig W European journal of organic chemistry 24415906 2013 Jul 1 https://www.ncbi.nlm.nih.gov/pubmed/24415906
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Ardecky, Robert J; Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Brown, Brock; Ganji, Santhi; Zou, Jiwen; Pass, Ian; Narisawa, Sonoko; Iano, Flavia Godoy; Rosenstein, Craig; Cheltsov, Anton; Rascon, Justin; Hedrick, Michael; Gasior, Carlton; Forster, Anita; Bioorganic & medicinal chemistry letters 24412070 2014 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/24412070
The University of New Mexico Center for Molecular Discovery. Edwards, Bruce S; Gouveia, Kristine; Oprea, Tudor I; Sklar, Larry A Combinatorial chemistry & high throughput screening 24409953 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24409953
Collaborative pre-competitive preclinical drug discovery with academics and pharma/biotech partners at Sanford|Burnham: infrastructure, capabilities & operational models. Chung, Thomas D Y Combinatorial chemistry & high throughput screening 24409951 2014 Mar https://www.ncbi.nlm.nih.gov/pubmed/24409951
Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. Huang, Yijun; Wolf, Siglinde; Beck, Barbara; Kohler, Lisa-Maria; Khoury, Kareem; Popowicz, Grzegorz M; Goda, Sayed K; Subklewe, Marion; Twarda, Aleksandra; Holak, Tad A; Domling, Alexander ACS chemical biology 24405416 2014 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/24405416
Covalent inhibition of the lymphoid tyrosine phosphatase. Ahmed, Vanessa F; Bottini, Nunzio; Barrios, Amy M ChemMedChem 24403103 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24403103
Grubbs cross-metathesis pathway for a scalable synthesis of ýý-keto-*,*-unsaturated esters. Nair, Reji N; Bannister, Thomas D The Journal of organic chemistry 24393145 2014 Feb 7 https://www.ncbi.nlm.nih.gov/pubmed/24393145
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. Luci, Diane K; Jameson 2nd, J Brian; Yasgar, Adam; Diaz, Giovanni; Joshi, Netra; Kantz, Auric; Markham, Kate; Perry, Steve; Kuhn, Norine; Yeung, Jennifer; Kerns, Edward H; Schultz, Lena; Holinstat, Michael; Nadler, Jerry L; Taylor-Fishwick, David A; Jadha Journal of medicinal chemistry 24393039 2014 Jan 23 https://www.ncbi.nlm.nih.gov/pubmed/24393039
Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Wang, Ying; Lonard, David M; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy G; Wang, Jin; Qi, Ruogu; Matzuk, Alexander J; Song, Xianzhou; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; Zhou, Suoling; Liao, Lan; Xu, Jianming; O'Malley, Bert Cancer research 24390736 2014 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24390736
A novel analgesic isolated from a traditional chinese medicine. Zhang, Yan; Wang, Chaoran; Wang, Lien; Parks, Gregory Scott; Zhang, Xiuli; Guo, Zhimou; Ke, Yanxiong; Li, Kang-Wu; Kim, Mi Kyeong; Vo, Benjamin; Borrelli, Emiliana; Ge, Guangbo; Yang, Ling; Wang, Zhiwei; Garcia-Fuster, M Julia; Luo, Z David; Liang, Xinmia Current biology : CB 24388848 2014 Jan 20 https://www.ncbi.nlm.nih.gov/pubmed/24388848
High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity. Ofori, Leslie O; Hilimire, Thomas A; Bennett, Ryan P; Brown Jr, Nathaniel W; Smith, Harold C; Miller, Benjamin L Journal of medicinal chemistry 24387306 2014 Feb 13 https://www.ncbi.nlm.nih.gov/pubmed/24387306
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Chris A; Bi, Danse; Basha, Fatima Z; Hanson, Paul R Heterocycles 24385680 2012 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/24385680
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol. Zang, Qin; Zhou, Aihua; Javed, Salim; Maity, Pradip K; Knudtson, Chris A; Bi, Danse; Hastings, Jared J; Basha, Fatima Z; Hanson, Paul R Heterocycles 24385679 2012 Dec 31 https://www.ncbi.nlm.nih.gov/pubmed/24385679
Activation of the nuclear factor e2-related factor 2 pathway by novel natural products halomadurones a-d and a synthetic analogue. Wyche, Thomas P; Standiford, Miranda; Hou, Yanpeng; Braun, Doug; Johnson, Delinda A; Johnson, Jeffrey A; Bugni, Tim S Marine drugs 24351907 2013 https://www.ncbi.nlm.nih.gov/pubmed/24351907
Counterion effects in the catalytic stereoselective synthesis of 2,3'-pyrrolidinyl spirooxindoles. MacDonald, Jacob P; Shupe, Benjamin H; Schreiber, John D; Franz, Annaliese K Chemical communications (Cambridge, England) 24336395 2014 May 25 https://www.ncbi.nlm.nih.gov/pubmed/24336395
Imidazole-derived agonists for the neurotensin 1 receptor. Hershberger, Paul M; Hedrick, Michael P; Peddibhotla, Satyamaheshwar; Mangravita-Novo, Arianna; Gosalia, Palak; Li, Yujie; Gray, Wilson; Vicchiarelli, Michael; Smith, Layton H; Chung, Thomas D Y; Thomas, James B; Caron, Marc G; Pinkerton, Anthony B; Barak Bioorganic & medicinal chemistry letters 24332089 2014 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/24332089
A simple one-pot 2-step N-1-alkylation of indoles with *-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles. Martinez-Ariza, Guillermo; Ayaz, Muhammad; Hulme, Christopher Tetrahedron letters 24327792 2013 Dec 4 https://www.ncbi.nlm.nih.gov/pubmed/24327792
Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones. Singh, Gurpreet; Meyer, Angelica; Aube, Jeffrey The Journal of organic chemistry 24325280 2014 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/24325280
Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism. Kwan, Jason C; Schmidt, Eric W PloS one 24324632 2013 https://www.ncbi.nlm.nih.gov/pubmed/24324632
Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Zaytseva, Natalya; Lynn, Jeffery G; Wu, Qi; Mudaliar, Deepti J; Sun, Haiyan; Kuang, Patty Q; Fang, Ye Sensors and actuators. B, Chemical 24319319 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24319319
High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. Sharma, Kamal; Choi, Se-Young; Zhang, Yong; Nieland, Thomas J F; Long, Shunyou; Li, Min; Huganir, Richard L Cell reports 24316074 2013 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/24316074
Application of ion-sensitive field effect transistors for ion channel screening. Walsh, Kenneth B; DeRoller, Nicholas; Zhu, Yihao; Koley, Goutam Biosensors & bioelectronics 24315877 2014 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/24315877
Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams. Asad, Naeem; Samarakoon, Thiwanka B; Zang, Qin; Loh, Joanna K; Javed, Salim; Hanson, Paul R Organic letters 24313225 2014 Jan 3 https://www.ncbi.nlm.nih.gov/pubmed/24313225
Multiplex cytological profiling assay to measure diverse cellular states. Gustafsdottir, Sigrun M; Ljosa, Vebjorn; Sokolnicki, Katherine L; Anthony Wilson, J; Walpita, Deepika; Kemp, Melissa M; Petri Seiler, Kathleen; Carrel, Hyman A; Golub, Todd R; Schreiber, Stuart L; Clemons, Paul A; Carpenter, Anne E; Shamji, Alykhan F PloS one 24312513 2013 https://www.ncbi.nlm.nih.gov/pubmed/24312513
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Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. Yun, Bogeon; Lee, HeeJung; Ghosh, Moumita; Cravatt, Benjamin F; Hsu, Ku-Lung; Bonventre, Joseph V; Ewing, Heather; Gelb, Michael H; Leslie, Christina C The Journal of biological chemistry 24297180 2014 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/24297180
An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support. Fei, Yiyan; Landry, James P; Li, Yanhong; Yu, Hai; Lau, Kam; Huang, Shengshu; Chokhawala, Harshal A; Chen, Xi; Zhu, X D The Review of scientific instruments 24289409 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/24289409
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Doherty, Joanne R; Yang, Chunying; Scott, Kristen E N; Cameron, Michael D; Fallahi, Mohammad; Li, Weimin; Hall, Mark A; Amelio, Antonio L; Mishra, Jitendra K; Li, Fangzheng; Tortosa, Mariola; Genau, Heide Marika; Rounbehler, Robert J; Lu, Yunqi; Dang, Chi Cancer research 24285728 2014 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/24285728
Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Du, Lin; Robles, Andrew J; King, Jarrod B; Powell, Douglas R; Miller, Andrew N; Mooberry, Susan L; Cichewicz, Robert H Angewandte Chemie (International ed. in English) 24285637 2014 Jan 13 https://www.ncbi.nlm.nih.gov/pubmed/24285637
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Inhibiting AMPylation: A Novel Screen To Identify the First Small Molecule Inhibitors of Protein AMPylation. Lewallen, Daniel M; Sreelatha, Anju; Dharmarajan, Venkatasubramanian; Madoux, Franck; Chase, Peter; Griffin, Patrick R; Orth, Kim; Hodder, Peter; Thompson, Paul R ACS chemical biology 24274060 2013 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/24274060
Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. Raphemot, Rene; Kadakia, Rishin J; Olsen, Michelle L; Banerjee, Sreedatta; Days, Emily; Smith, Stephen S; Weaver, C David; Denton, Jerod S Assay and drug development technologies 24266659 2013 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/24266659
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Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC). Chen, Haijun; Wild, Christopher; Zhou, Xiaobin; Ye, Na; Cheng, Xiaodong; Zhou, Jia Journal of medicinal chemistry 24256330 2013 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/24256330
Secoemestrin D, a Cytotoxic Epitetrathiodioxopiperizine, and Emericellenes A-E, Five Sesterterpenoids from Emericella sp. AST0036, a Fungal Endophyte of Astragalus lentiginosus1. Xu, Ya-Ming; Espinosa-Artiles, Patricia; Liu, Mangping X; Arnold, A Elizabeth; Gunatilaka, A A Leslie Journal of natural products 24251417 2013 Nov 19 https://www.ncbi.nlm.nih.gov/pubmed/24251417
Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). Ullah, Farman; Zang, Qin; Javed, Salim; Zhou, Aihua; Knudtson, Christopher A; Bi, Danse; Hanson, Paul R; Organ, Michael G Journal of flow chemistry 24244871 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/24244871
Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS). Ullah, Farman; Zang, Qin; Javed, Salim; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul R; Organ, Michael G Synthesis 24244052 2012 https://www.ncbi.nlm.nih.gov/pubmed/24244052
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Inhibition of the TRPC5 ion channel protects the kidney filter. Schaldecker, Thomas; Kim, Sookyung; Tarabanis, Constantine; Tian, Dequan; Hakroush, Samy; Castonguay, Philip; Ahn, Wooin; Wallentin, Hanna; Heid, Hans; Hopkins, Corey R; Lindsley, Craig W; Riccio, Antonio; Buvall, Lisa; Weins, Astrid; Greka, Anna The Journal of clinical investigation 24231357 2013 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/24231357
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Discovery of the First M5-Selective and CNS Penetrant Negative Allosteric Modulator (NAM) of a Muscarinic Acetylcholine Receptor: (S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W Journal of medicinal chemistry 24164599 2013 Nov 27 https://www.ncbi.nlm.nih.gov/pubmed/24164599
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Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Hsu, Ku-Lung; Tsuboi, Katsunori; Whitby, Landon R; Speers, Anna E; Pugh, Holly; Inloes, Jordon; Cravatt, Benjamin F Journal of medicinal chemistry 24152245 2013 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/24152245
MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. Liu, Wei-Ting; Lamsa, Anne; Wong, Weng Ruh; Boudreau, Paul D; Kersten, Roland; Peng, Yao; Moree, Wilna J; Duggan, Brendan M; Moore, Bradley S; Gerwick, William H; Linington, Roger G; Pogliano, Kit; Dorrestein, Pieter C The Journal of antibiotics 24149839 2013 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/24149839
Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans. Stefan, Christopher P; Cunningham, Kyle W The Journal of biological chemistry 24142703 2013 Nov 29 https://www.ncbi.nlm.nih.gov/pubmed/24142703
Human protamine-1 as an MRI reporter gene based on chemical exchange. Bar-Shir, Amnon; Liu, Guanshu; Chan, Kannie W Y; Oskolkov, Nikita; Song, Xiaolei; Yadav, Nirbhay N; Walczak, Piotr; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf A ACS chemical biology 24138139 2014 Jan 17 https://www.ncbi.nlm.nih.gov/pubmed/24138139
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Modulators of the Sphingosine 1-phosphate receptor 1. Urbano, Mariangela; Guerrero, Miguel; Rosen, Hugh; Roberts, Edward Bioorganic & medicinal chemistry letters 24125884 2013 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/24125884
Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI. Liu, Guanshu; Bettegowda, Chetan; Qiao, Yuan; Staedtke, Verena; Chan, Kannie W Y; Bai, Renyuan; Li, Yuguo; Riggins, Gregory J; Kinzler, Kenneth W; Bulte, Jeff W M; McMahon, Michael T; Gilad, Assaf A; Vogelstein, Bert; Zhou, Shibin; van Zijl, Peter C M Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 24123389 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24123389
A systems chemical biology study of malate synthase and isocitrate lyase inhibition in Mycobacterium tuberculosis during active and NRP growth. May, Elebeoba E; Leitao, Andrei; Tropsha, Alexander; Oprea, Tudor I Computational biology and chemistry 24121675 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24121675
Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3). Robinson, James; Smith, Anthony; Sturchler, Emmanuel; Tabrizifard, Sahba; Kamenecka, Theodore; McDonald, Patricia Assay and drug development technologies 24116939 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/24116939
A pilot biomedical engineering course in rapid prototyping for mobile health. Stokes, Todd H; Venugopalan, Janani; Hubbard, Elena N; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 24110238 2013 https://www.ncbi.nlm.nih.gov/pubmed/24110238
Challenges and triumphs to genomics-based natural product discovery. Jensen, Paul R; Chavarria, Krystle L; Fenical, William; Moore, Bradley S; Ziemert, Nadine Journal of industrial microbiology & biotechnology 24104399 2014 Feb https://www.ncbi.nlm.nih.gov/pubmed/24104399
A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). Shahinas, Dea; Folefoc, Asongna; Taldone, Tony; Chiosis, Gabriela; Crandall, Ian; Pillai, Dylan R PloS one 24098696 2013 https://www.ncbi.nlm.nih.gov/pubmed/24098696
Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation. Wan, Xia; Lu, Yungang; Chen, Xueqin; Xiong, Jian; Zhou, Yuanda; Li, Ping; Xia, Bingqing; Li, Min; Zhu, Michael X; Gao, Zhaobing Pflugers Archiv : European journal of physiology 24092046 2014 Jul https://www.ncbi.nlm.nih.gov/pubmed/24092046
Selective photoinactivation of Candida albicans in the non-vertebrate host infection model Galleria mellonella. Chibebe Junior, Jose; Sabino, Caetano P; Tan, Xiaojiang; Junqueira, Juliana C; Wang, Yan; Fuchs, Beth B; Jorge, Antonio O C; Tegos, George P; Hamblin, Michael R; Mylonakis, Eleftherios BMC microbiology 24083556 2013 https://www.ncbi.nlm.nih.gov/pubmed/24083556
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding. Turlington, Mark; Chun, Aspen; Tomar, Sakshi; Eggler, Aimee; Grum-Tokars, Valerie; Jacobs, Jon; Daniels, J Scott; Dawson, Eric; Saldanha, Adrian; Chase, Peter; Baez-Santos, Yahira M; Lindsley, Craig W; Hodder, Peter; Mesecar, Andrew D; Stauffer, Shaun R Bioorganic & medicinal chemistry letters 24080461 2013 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/24080461
Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751. Wijeratne, E M Kithsiri; He, Hongping; Franzblau, Scott G; Hoffman, Angela M; Gunatilaka, A A Leslie Journal of natural products 24079882 2013 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/24079882
Stereocontrol in asymmetric ýý-lactam syntheses from imines and cyanosuccinic anhydrides. Pattawong, Ommidala; Tan, Darlene Q; Fettinger, James C; Shaw, Jared T; Cheong, Paul Ha-Yeon Organic letters 24070216 2013 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/24070216
Stereoselective synthesis of ýý-lactams from imines and cyanosuccinic anhydrides. Tan, Darlene Q; Younai, Ashkaan; Pattawong, Ommidala; Fettinger, James C; Cheong, Paul Ha-Yeon; Shaw, Jared T Organic letters 24070117 2013 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/24070117
Synthesis and Characterization of Thiolate-Oxo Ligated Zinc Alkyl Derivatives for Production of Zn-Based Nanoparticles. Boyle, Timothy J; Pratt 3rd, Harry D; Alam, Todd M; Headley, Thomas; Rodriguez, Mark A European journal of inorganic chemistry 24068879 2009 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/24068879
Indolo[3,2-a]carbazoles from a deep-water sponge of the genus Asteropus. Russell, Floyd; Harmody, Dedra; McCarthy, Peter J; Pomponi, Shirley A; Wright, Amy E Journal of natural products 24063539 2013 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/24063539
The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm. Kapur, Sunil; Macrae, Calum A Frontiers in physiology 24062689 2013 https://www.ncbi.nlm.nih.gov/pubmed/24062689
Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy. Vo-Dinh, Tuan; Fales, Andrew M; Griffin, Guy D; Khoury, Christopher G; Liu, Yang; Ngo, Hoan; Norton, Stephen J; Register, Janna K; Wang, Hsin-Neng; Yuan, Hsiangkuo Nanoscale 24056945 2013 Nov 7 https://www.ncbi.nlm.nih.gov/pubmed/24056945
Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide Turlington, Mark; Noetzel, Meredith J; Chun, Aspen; Zhou, Ya; Gogliotti, Rocco D; Nguyen, Elizabeth D; Gregory, Karen J; Vinson, Paige N; Rook, Jerri M; Gogi, Kiran K; Xiang, Zixiu; Bridges, Thomas M; Daniels, J Scott; Jones, Carrie; Niswender, Colleen M; Journal of medicinal chemistry 24050755 2013 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/24050755
Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders. NULL Drug discovery today. Technologies 24050278 2013 https://www.ncbi.nlm.nih.gov/pubmed/24050278
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. Ljosa, Vebjorn; Caie, Peter D; Ter Horst, Rob; Sokolnicki, Katherine L; Jenkins, Emma L; Daya, Sandeep; Roberts, Mark E; Jones, Thouis R; Singh, Shantanu; Genovesio, Auguste; Clemons, Paul A; Carragher, Neil O; Carpenter, Anne E Journal of biomolecular screening 24045582 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24045582
Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. Storaska, Andrew J; Mei, Jian P; Wu, Meng; Li, Min; Wade, Susan M; Blazer, Levi L; Sjogren, Benita; Hopkins, Corey R; Lindsley, Craig W; Lin, Zhihong; Babcock, Joseph J; McManus, Owen B; Neubig, Richard R Cellular signalling 24041654 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/24041654
Identification of Potent and Selective Diphenylpropanamide RORýý Inhibitors. Huh, Jun R; Englund, Erika E; Wang, Hang; Huang, Ruili; Huang, Pengxiang; Rastinejad, Fraydoon; Inglese, James; Austin, Christopher P; Johnson, Ronald L; Huang, Wenwei; Littman, Dan R ACS medicinal chemistry letters 24040486 2013 Jan 10 https://www.ncbi.nlm.nih.gov/pubmed/24040486
A general, enantioselective synthesis of ýý- and ýý-fluoroamines. O'Reilly, Matthew C; Lindsley, Craig W Tetrahedron letters 24039308 2013 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/24039308
Nuclear magnetic resonance at the picomole level of a DNA adduct. Kautz, Roger; Wang, Poguang; Giese, Roger W Chemical research in toxicology 24028148 2013 Oct 21 https://www.ncbi.nlm.nih.gov/pubmed/24028148
A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In vitro and In vivo. Abulwerdi, Fardokht; Liao, Chenzhong; Liu, Meilan; Azmi, Asfar S; Aboukameel, Amro; Mady, Ahmed Sa; Gulappa, Thippeswamy; Cierpicki, Tomasz; Owens, Scott; Zhang, Tao; Sun, Duxin; Stuckey, Jeanne A; Mohammad, Ramzi M; Nikolovska-Coleska, Zaneta Molecular cancer therapeutics 24019208 2013 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/24019208
Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Rosenthal, Andrew S; Dexheimer, Thomas S; Gileadi, Opher; Nguyen, Giang H; Chu, Wai Kit; Hickson, Ian D; Jadhav, Ajit; Simeonov, Anton; Maloney, David J Bioorganic & medicinal chemistry letters 24012121 2013 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/24012121
Amphiphilic suramin dissolves Matrigel, causing an 'inhibition' artefact within in vitro angiogenesis assays. Prigozhina, Natalie L; Heisel, Andrew J; Seldeen, Jordan R; Cosford, Nicholas D P; Price, Jeffrey H International journal of experimental pathology 23998420 2013 Dec https://www.ncbi.nlm.nih.gov/pubmed/23998420
Size and crystallinity in protein-templated inorganic nanoparticles. Jolley, Craig C; Uchida, Masaki; Reichhardt, Courtney; Harrington, Richard; Kang, Sebyung; Klem, Michael T; Parise, John B; Douglas, Trevor Chemistry of materials : a publication of the American Chemical Society 23997427 2010 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/23997427
Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade. Gunawan, Steven; Hulme, Christopher Tetrahedron letters 23997316 2013 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/23997316
A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia. Singh, Harpreet; Shelat, Anang A; Singh, Amandeep; Boulos, Nidal; Williams, Richard T; Guy, R Kiplin Journal of biomolecular screening 23989453 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23989453
Identification of Inhibitors of Triacylglyceride Accumulation in Muscle Cells: Comparing HTS Results from 1536-Well Plate-Based and High-Content Platforms. Sugarman, Eliot; Koo, Ada; Suyama, Eigo; Ruidiaz, Manuel E; Heynen-Genel, Susanne; Nguyen, Kevin H; Vasile, Stefan; Soundarapandian, Mangala M; Vega, Rick B; Kelly, Daniel P; Smith, Layton H; Malany, Siobhan Journal of biomolecular screening 23989452 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23989452
A High-Voltage Integrated Circuit Engine for a Dielectrophoresis-based Programmable Micro-Fluidic Processor. Current, K Wayne; Yuk, Kelvin; McConaghy, Charles; Gascoyne, Peter R C; Schwartz, Jon A; Vykoukal, Jody V; Andrews, Craig Proceedings ... International Conference on MEMS, NANO, and Smart Systems. International Conference on MEMS, NANO, and Smart Systems 23989241 2005 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/23989241
Spectral bounds on plasmon resonances for Ag and Au prolate and oblate nanospheroids. Norton, Stephen J; Vo-Dinh, Tuan Journal of nanophotonics 23977404 2008 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/23977404
Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization. Khoury, Christopher G; Vo-Dinh, Tuan The journal of physical chemistry. C, Nanomaterials and interfaces 23977403 2008 https://www.ncbi.nlm.nih.gov/pubmed/23977403
Assessing the Location of Surface Plasmons Over Nanotriangle and Nanohole Arrays of Different Size and Periodicity. Correia-Ledo, Debby; Gibson, Kirsty F; Dhawan, Anuj; Couture, Maxime; Vo-Dinh, Tuan; Graham, Duncan; Masson, Jean-Francois The journal of physical chemistry. C, Nanomaterials and interfaces 23977402 2012 Mar 29 https://www.ncbi.nlm.nih.gov/pubmed/23977402
Theoretical Simulation and Focused Ion Beam Fabrication of Gold Nanostructures For Surface-Enhanced Raman Scattering (SERS). Dhawan, Anuj; Gerhold, Michael; Vo-Dinh, Tuan Nanobiotechnology : the journal at the intersection of nanotechnology, molecular biology, and biomedical sciences 23976888 2007 Dec https://www.ncbi.nlm.nih.gov/pubmed/23976888
Plasmon Resonances of Nanoshells of Spheroidal Shape. Norton, Stephen J; Vo-Dinh, Tuan IEEE transactions on nanotechnology 23976876 2007 https://www.ncbi.nlm.nih.gov/pubmed/23976876
FIB Fabrication of Metallic Nanostructures on End-Faces of Optical Fibers for Chemical Sensing Applications. Dhawan, A; Muth, J F; Leonard, D N; Gerhold, M D; Gleeson, J; Vo-Dinh, T; Russell, P E Journal of vacuum science & technology. B, Microelectronics and nanometer structures : processing, measurement, and phenomena : an official journal of the American Vacuum Society 23976838 2008 https://www.ncbi.nlm.nih.gov/pubmed/23976838
Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles. Arnold, David M; Laporte, Matthew G; Anderson, Shelby M; Wipf, Peter Tetrahedron 23976798 2013 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/23976798
Small-molecule antagonists of melanopsin-mediated phototransduction. Jones, Kenneth A; Hatori, Megumi; Mure, Ludovic S; Bramley, Jayne R; Artymyshyn, Roman; Hong, Sang-Phyo; Marzabadi, Mohammad; Zhong, Huailing; Sprouse, Jeffrey; Zhu, Quansheng; Hartwick, Andrew T E; Sollars, Patricia J; Pickard, Gary E; Panda, Satchidanan Nature chemical biology 23974117 2013 Oct https://www.ncbi.nlm.nih.gov/pubmed/23974117
On the Nonnegative Rank of Euclidean Distance Matrices. Lin, Matthew M; Chu, Moody T Linear algebra and its applications 23966751 2010 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/23966751
Parameter Reconstruction of Vibration Systems from Partial Eigeninformation. Dong, Bo; Lin, Matthew M; Chu, Moody T Journal of sound and vibration 23966750 2009 Nov 13 https://www.ncbi.nlm.nih.gov/pubmed/23966750
Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions. Nguyen, Huy H; Palazzo, Teresa A; Kurth, Mark J Organic letters 23961714 2013 Sep 6 https://www.ncbi.nlm.nih.gov/pubmed/23961714
Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues. Schulte, Michael L; Turlington, Mark L; Phatak, Sharangdhar S; Harp, Joel M; Stauffer, Shaun R; Lindsley, Craig W Chemistry (Weinheim an der Bergstrasse, Germany) 23956045 2013 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/23956045
Metabolic imaging of patients with prostate cancer using hyperpolarized [1-ýýýýC]pyruvate. Nelson, Sarah J; Kurhanewicz, John; Vigneron, Daniel B; Larson, Peder E Z; Harzstark, Andrea L; Ferrone, Marcus; van Criekinge, Mark; Chang, Jose W; Bok, Robert; Park, Ilwoo; Reed, Galen; Carvajal, Lucas; Small, Eric J; Munster, Pamela; Weinberg, Vivian K Science translational medicine 23946197 2013 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/23946197
VirD: a virion display array for profiling functional membrane proteins. Hu, Shaohui; Feng, Yingzhu; Henson, Brandon; Wang, Bochu; Huang, Xiaofang; Li, Min; Desai, Prashant; Zhu, Heng Analytical chemistry 23941274 2013 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/23941274
Integrated analysis of drug-induced gene expression profiles predicts novel hERG inhibitors. Babcock, Joseph J; Du, Fang; Xu, Kaiping; Wheelan, Sarah J; Li, Min PloS one 23936032 2013 https://www.ncbi.nlm.nih.gov/pubmed/23936032
Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. Deng, Huayun; Sun, Haiyan; Fang, Ye Journal of pharmacological and toxicological methods 23933114 2013 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/23933114
Quantitative affinity electrophoresis of RNA-small molecule interactions by cross-linking the ligand to acrylamide. Boodram, Sherry N; McCann, Lucas C; Organ, Michael G; Johnson, Philip E Analytical biochemistry 23928050 2013 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/23928050
Rapid parallel flow cytometry assays of active GTPases using effector beads. Buranda, Tione; Basuray, Soumik; Swanson, Scarlett; Agola, Jacob; Bondu, Virginie; Wandinger-Ness, Angela Analytical biochemistry 23928044 2013 Aug 6 https://www.ncbi.nlm.nih.gov/pubmed/23928044
Spiro Fused Diterpene-Indole Alkaloids from a Creek-Bottom-Derived Aspergillus terreus. Cai, Shengxin; Du, Lin; Gerea, Alexandra L; King, Jarrod B; You, Jianlan; Cichewicz, Robert H Organic letters 23924243 2013 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/23924243
Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. Ramadhar, Timothy R; Beemelmanns, Christine; Currie, Cameron R; Clardy, Jon The Journal of antibiotics 23921819 2014 Jan https://www.ncbi.nlm.nih.gov/pubmed/23921819
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Ramos-Hunter, Susan J; Engers, Darren W; Kaufmann, Kristian; Du, Yu; Lindsley, Craig W; Weaver, C David; Sulikowski, Gary A Bioorganic & medicinal chemistry letters 23916258 2013 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/23916258
Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. Montaser, Rana; Paul, Valerie J; Luesch, Hendrik Organic letters 23915229 2013 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/23915229
Bifunctional building blocks in the Ugi-azide condensation reaction: a general strategy toward exploration of new molecular diversity. Gunawan, Steven; Hulme, Christopher Organic & biomolecular chemistry 23912086 2013 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/23912086
A highly specific cell-based high-throughput screening assay for ligands of cyclic adenosine monophosphate receptor protein in gram-negative bacteria. Wang, Hongxia; Silva, Anisia J; Rasmussen, Lynn; White, E Lucile; Benitez, Jorge A Assay and drug development technologies 23906348 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23906348
A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors. Du, Yuhong; Fu, Robert W; Lou, Bin; Zhao, Jing; Qui, Min; Khuri, Fadlo R; Fu, Haian Assay and drug development technologies 23906346 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23906346
Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model. Grant, Sarah Schmidt; Kawate, Tomohiko; Nag, Partha P; Silvis, Melanie R; Gordon, Katherine; Stanley, Sarah A; Kazyanskaya, Edward; Nietupski, Raymond; Golas, Aaron; Fitzgerald, Michael; Cho, Sanghyun; Franzblau, Scott G; Hung, Deborah T ACS chemical biology 23898841 2013 Oct 18 https://www.ncbi.nlm.nih.gov/pubmed/23898841
A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Stallforth, Pierre; Brock, Debra A; Cantley, Alexandra M; Tian, Xiangjun; Queller, David C; Strassmann, Joan E; Clardy, Jon Proceedings of the National Academy of Sciences of the United States of America 23898207 2013 Sep 3 https://www.ncbi.nlm.nih.gov/pubmed/23898207
NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41. Gochin, Miriam; Whitby, Landon R; Phillips, Aaron H; Boger, Dale L Journal of computer-aided molecular design 23893342 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23893342
Emerging trends in the discovery of natural product antibacterials. Bologa, Cristian G; Ursu, Oleg; Oprea, Tudor I; Melancon 3rd, Charles E; Tegos, George P Current opinion in pharmacology 23890825 2013 Jul 24 https://www.ncbi.nlm.nih.gov/pubmed/23890825
An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins. Gao, Xue; Jiang, Wei; Jimenez-Oses, Gonzalo; Choi, Moon Seok; Houk, Kendall N; Tang, Yi; Walsh, Christopher T Chemistry & biology 23890005 2013 Jul 25 https://www.ncbi.nlm.nih.gov/pubmed/23890005
pCAP-based peptide substrates: The new tool in the box of tyrosine phosphatase assays. Stanford, Stephanie M; Krishnamurthy, Divya; Kulkarni, Rhushikesh A; Karver, Caitlin E; Bruenger, Eveline; Walker, Logan M; Ma, Chen-Ting; Chung, Thomas D Y; Sergienko, Eduard; Bottini, Nunzio; Barrios, Amy M Methods (San Diego, Calif.) 23886911 2013 Jul 22 https://www.ncbi.nlm.nih.gov/pubmed/23886911
Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis. Al-Mestarihi, Ahmad; Romo, Anthony; Liu, Hung-wen; Bachmann, Brian O Journal of the American Chemical Society 23885759 2013 Aug 7 https://www.ncbi.nlm.nih.gov/pubmed/23885759
Analysis of High-Dimensional Structure-Activity Screening Datasets Using the Optimal Bit String Tree. Zhang, Ke; Hughes-Oliver, Jacqueline M; Young, S Stanley Technometrics : a journal of statistics for the physical, chemical, and engineering sciences 23878407 2013 https://www.ncbi.nlm.nih.gov/pubmed/23878407
Production of ýý-galactosylceramide by a prominent member of the human gut microbiota. Wieland Brown, Laura C; Penaranda, Cristina; Kashyap, Purna C; Williams, Brianna B; Clardy, Jon; Kronenberg, Mitchell; Sonnenburg, Justin L; Comstock, Laurie E; Bluestone, Jeffrey A; Fischbach, Michael A PLoS biology 23874157 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23874157
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Santagata, Sandro; Mendillo, Marc L; Tang, Yun-chi; Subramanian, Aravind; Perley, Casey C; Roche, Stephane P; Wong, Bang; Narayan, Rajiv; Kwon, Hyoungtae; Koeva, Martina; Amon, Angelika; Golub, Todd R; Porco Jr, John A; Whitesell, Luke; Lindquist, Susan Science (New York, N.Y.) 23869022 2013 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/23869022
Novel diuretic targets. Denton, Jerod S; Pao, Alan C; Maduke, Merritt American journal of physiology. Renal physiology 23863472 2013 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/23863472
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling. Rahmouni, Souad; Delacroix, Laurence; Liu, Wallace H; Tautz, Lutz Methods in molecular biology (Clifton, N.J.) 23860658 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860658
High-throughput screening for protein tyrosine phosphatase activity modulators. Tautz, Lutz; Sergienko, Eduard A Methods in molecular biology (Clifton, N.J.) 23860657 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860657
Protein tyrosine phosphatases: structure, function, and implication in human disease. Tautz, Lutz; Critton, David A; Grotegut, Stefan Methods in molecular biology (Clifton, N.J.) 23860656 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860656
New activity assays for ENPP1 with physiological substrates ATP and ADP. Ma, Chen-Ting; Sergienko, Eduard A Methods in molecular biology (Clifton, N.J.) 23860653 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860653
Modulators of intestinal alkaline phosphatase. Bobkova, Ekaterina V; Kiffer-Moreira, Tina; Sergienko, Eduard A Methods in molecular biology (Clifton, N.J.) 23860652 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860652
A method for direct assessment of tissue-nonspecific alkaline phosphatase (TNAP) inhibitors in blood samples. Sergienko, Eduard A; Sun, Qing; Ma, Chen-Ting Methods in molecular biology (Clifton, N.J.) 23860649 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860649
Robotic implementation of assays: tissue-nonspecific alkaline phosphatase (TNAP) case study. Chung, Thomas D Y Methods in molecular biology (Clifton, N.J.) 23860647 2013 https://www.ncbi.nlm.nih.gov/pubmed/23860647
A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Satsu, Hideo; Schaeffer, Marie-Therese; Guerrero, Miguel; Saldana, Adrian; Eberhart, Christina; Hodder, Peter; Cayanan, Charmagne; Schurer, Stephan; Bhhatarai, Barun; Roberts, Ed; Rosen, Hugh; Brown, Steven J Bioorganic & medicinal chemistry 23849205 2013 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/23849205
Integrative chemical-biological read-across approach for chemical hazard classification. Low, Yen; Sedykh, Alexander; Fourches, Denis; Golbraikh, Alexander; Whelan, Maurice; Rusyn, Ivan; Tropsha, Alexander Chemical research in toxicology 23848138 2013 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/23848138
Regulation of proteolysis by human deubiquitinating enzymes. Eletr, Ziad M; Wilkinson, Keith D Biochimica et biophysica acta 23845989 2013 Jul 9 https://www.ncbi.nlm.nih.gov/pubmed/23845989
Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Wen, Wandong; Wu, Wenjun; Romaine, Ian M; Kaufmann, Kristian; Du, Yu; Sulikowski, Gary A; Weaver, C David; Lindsley, Craig W Bioorganic & medicinal chemistry letters 23838260 2013 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/23838260
Small-molecule procaspase activators identified using fluorescence polarization. Vickers, Chris J; Gonzalez-Paez, Gonzalo E; Umotoy, Jeffrey C; Cayanan-Garrett, Charmagne; Brown, Steven J; Wolan, Dennis W Chembiochem : a European journal of chemical biology 23836614 2013 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/23836614
Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae. Napper, Andrew D; Motlekar, Nuzhat; de Almeida, Rogerio Alves; Pavitt, Graham D Current protocols in chemical biology 23836585 2011 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23836585
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Identification of a ýý-ýý opioid receptor heteromer-biased agonist with antinociceptive activity. Gomes, Ivone; Fujita, Wakako; Gupta, Achla; Saldanha, Adrian S; Negri, Ana; Pinello, Christine E; Roberts, Edward; Filizola, Marta; Hodder, Peter; Devi, Lakshmi A Proceedings of the National Academy of Sciences of the United States of America 23818586 2013 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/23818586
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Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. Vatansever, Fatma; de Melo, Wanessa C M A; Avci, Pinar; Vecchio, Daniela; Sadasivam, Magesh; Gupta, Asheesh; Chandran, Rakkiyappan; Karimi, Mahdi; Parizotto, Nivaldo A; Yin, Rui; Tegos, George P; Hamblin, Michael R FEMS microbiology reviews 23802986 2013 Nov https://www.ncbi.nlm.nih.gov/pubmed/23802986
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Picking sides: Distinct roles for CYP76M6 and -8 in rice oryzalexin biosynthesis. Wu, Yisheng; Wang, Qiang; Hillwig, Matthew L; Peters, Reuben J The Biochemical journal 23795884 2013 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/23795884
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Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics. Wang, Hsin-Neng; Fales, Andrew M; Zaas, Aimee K; Woods, Christopher W; Burke, Thomas; Ginsburg, Geoffrey S; Vo-Dinh, Tuan Analytica chimica acta 23790305 2013 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/23790305
Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Pinilla, Clemencia; Edwards, Bruce S; Appel, Jon R; Yates-Gibbins, Tina; Giulianotti, Marc A; Medina-Franco, Jose L; Young, Susan M; Santos, Radleigh G; Sklar, Larry A; Houghten, Richard A Molecular pharmacology 23788657 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23788657
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Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Blum, Gil; Bothwell, Ian R; Islam, Kabirul; Luo, Minkui Current protocols in chemical biology 23788324 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23788324
Development of highly selective casein kinase 1ýý/1ýý (CK1ýý/ýý) inhibitors with potent antiproliferative properties. Bibian, Mathieu; Rahaim, Ronald J; Choi, Jun Yong; Noguchi, Yoshihiko; Schurer, Stephan; Chen, Weimin; Nakanishi, Shima; Licht, Konstantin; Rosenberg, Laura H; Li, Lin; Feng, Yangbo; Cameron, Michael D; Duckett, Derek R; Cleveland, John L; Roush, William Bioorganic & medicinal chemistry letters 23787102 2013 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/23787102
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. Yeung, J; Apopa, P L; Vesci, J; Stolla, M; Rai, G; Simeonov, A; Jadhav, A; Fernandez-Perez, P; Maloney, D J; Boutaud, O; Holman, T R; Holinstat, M Thrombosis and haemostasis 23784669 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23784669
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In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. Wang, Rui; Mason, Daniel E; Choe, Keith P; Lewin, Alfred S; Peters, Eric C; Luesch, Hendrik ACS chemical biology 23773140 2013 Aug 16 https://www.ncbi.nlm.nih.gov/pubmed/23773140
Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays. Landry, James P; Fei, Yiyan; Zhu, Xiangdong; Ke, Yaohuang; Yu, Guoliang; Lee, Pierre Assay and drug development technologies 23772553 2013 Jun https://www.ncbi.nlm.nih.gov/pubmed/23772553
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. Xiao, Jingbo; Huang, Zaohua; Chen, Catherine Z; Agoulnik, Irina U; Southall, Noel; Hu, Xin; Jones, Raisa E; Ferrer, Marc; Zheng, Wei; Agoulnik, Alexander I; Marugan, Juan J Nature communications 23764525 2013 https://www.ncbi.nlm.nih.gov/pubmed/23764525
Various cyclization scaffolds by a truly Ugi 4-CR. Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, Alexander Organic & biomolecular chemistry 23760036 2013 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/23760036
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Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Ardecky, Robert J; Welsh, Kate; Finlay, Darren; Lee, Pooi San; Gonzalez-Lopez, Marcos; Ganji, Santhi Reddy; Ravanan, Palaniyandi; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D P Bioorganic & medicinal chemistry letters 23743278 2013 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/23743278
Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. De, Subhasis; Chen, Lu; Zhang, Shuxing; Gilbertson, Scott R ACS combinatorial science 23742807 2013 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/23742807
A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress. Wang, Hongxia; Zhang, Li; Silva, Anisia J; Benitez, Jorge A Antimicrobial agents and chemotherapy 23733460 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23733460
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. Kaufmann, Kristian; Romaine, Ian; Days, Emily; Pascual, Conrado; Malik, Adam; Yang, Liya; Zou, Bende; Du, Yu; Sliwoski, Greg; Morrison, Ryan D; Denton, Jerod; Niswender, Colleen M; Daniels, J Scott; Sulikowski, Gary A; Xie, Xinmin Simon; Lindsley, Craig W ACS chemical neuroscience 23730969 2013 Sep 18 https://www.ncbi.nlm.nih.gov/pubmed/23730969
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Floyd, Scott R; Pacold, Michael E; Huang, Qiuying; Clarke, Scott M; Lam, Fred C; Cannell, Ian G; Bryson, Bryan D; Rameseder, Jonathan; Lee, Michael J; Blake, Emily J; Fydrych, Anna; Ho, Richard; Greenberger, Benjamin A; Chen, Grace C; Maffa, Amanda; Del R Nature 23728299 2013 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/23728299
Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. Scott, Sarah A; Xiang, Yun; Mathews, Thomas P; Cho, Hyekyung P; Myers, David S; Armstrong, Michelle D; Tallman, Keri A; O'Reilly, Matthew C; Lindsley, Craig W; Brown, H Alex The Journal of biological chemistry 23723068 2013 Jul 12 https://www.ncbi.nlm.nih.gov/pubmed/23723068
The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors. Santos, Radleigh G; Appel, Jon R; Giulianotti, Marc A; Edwards, Bruce S; Sklar, Larry A; Houghten, Richard A; Pinilla, Clemencia Molecules (Basel, Switzerland) 23722730 2013 https://www.ncbi.nlm.nih.gov/pubmed/23722730
Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip. Ngo, Hoan Thanh; Wang, Hsin-Neng; Fales, Andrew M; Vo-Dinh, Tuan Analytical chemistry 23718777 2013 Jul 2 https://www.ncbi.nlm.nih.gov/pubmed/23718777
Discovery of (R)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu3 Selective and CNS Penetrant Negative Allosteric Modulator (NAM). Wenthur, Cody J; Morrison, Ryan; Felts, Andrew S; Smith, Katrina A; Engers, Julie L; Byers, Frank W; Daniels, J Scott; Emmitte, Kyle A; Conn, P Jeffrey; Lindsley, Craig W Journal of medicinal chemistry 23718281 2013 Jun 27 https://www.ncbi.nlm.nih.gov/pubmed/23718281
Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry. Xu, Zhigang; De Moliner, Fabio; Cappelli, Alexandra P; Hulme, Christopher Organic letters 23718233 2013 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/23718233
Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase. Harris, Michael T; Walker, Dawn M; Drew, Mark E; Mitchell, William G; Dao, Kevin; Schroeder, Chad E; Flaherty, Daniel P; Weiner, Warren S; Golden, Jennifer E; Morris, James C Antimicrobial agents and chemotherapy 23716053 2013 Aug https://www.ncbi.nlm.nih.gov/pubmed/23716053
Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. Rateb, Mostafa E; Yu, Zhiguo; Yan, Yijun; Yang, Dong; Huang, Tingting; Vodanovic-Jankovic, Sanja; Kron, Michael A; Shen, Ben The Journal of antibiotics 23715040 2013 May 29 https://www.ncbi.nlm.nih.gov/pubmed/23715040
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. Zhang, Liying; Sedykh, Alexander; Tripathi, Ashutosh; Zhu, Hao; Afantitis, Antreas; Mouchlis, Varnavas D; Melagraki, Georgia; Rusyn, Ivan; Tropsha, Alexander Toxicology and applied pharmacology 23707773 2013 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/23707773
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Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. Sweeney, Noreena L; Shadrick, William R; Mukherjee, Sourav; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David N The Journal of biological chemistry 23703611 2013 Jul 5 https://www.ncbi.nlm.nih.gov/pubmed/23703611
Multicomponent Assembly Processes for the Synthesis of Diverse Yohimbine and Corynanthe Alkaloid Analogues. Granger, Brett A; Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen F ACS combinatorial science 23697376 2013 Jun 4 https://www.ncbi.nlm.nih.gov/pubmed/23697376
Predicting drug-induced QT prolongation effects using multi-view learning. Zhang, Jintao; Huan, Jun IEEE transactions on nanobioscience 23694701 2013 Sep https://www.ncbi.nlm.nih.gov/pubmed/23694701
Inside job: ligand-receptor pharmacology beneath the plasma membrane. Babcock, Joseph J; Li, Min Acta pharmacologica Sinica 23685953 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23685953
Synthesis of a Library of "Lead-Like" ýý-Lactams by a One Pot, Four-Component Reaction. Martin, Kevin S; Di Maso, Michael J; Fettinger, James C; Shaw, Jared Thomas ACS combinatorial science 23682712 2013 May 17 https://www.ncbi.nlm.nih.gov/pubmed/23682712
Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology. Watson, Venita Gresham; Drake, Katherine M; Peng, Yu; Napper, Andrew D Assay and drug development technologies 23679849 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23679849
Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. Lu, Jiuyi; Chen, Minyong; Ren, Xiu-Rong; Wang, Jiangbo; Lyerly, H Kim; Barak, Larry; Chen, Wei PloS one 23671675 2013 https://www.ncbi.nlm.nih.gov/pubmed/23671675
Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine. Blum, Gil; Islam, Kabirul; Luo, Minkui Current protocols in chemical biology 23667794 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23667794
Using Azido Analogue of S-Adenosyl-L-methionine for Bioorthogonal Profiling of Protein Methylation (BPPM). Blum, Gil; Islam, Kabirul; Luo, Minkui Current protocols in chemical biology 23667794 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23667794
Mechanism-based corrector combination restores ýýF508-CFTR folding and function. Okiyoneda, Tsukasa; Veit, Guido; Dekkers, Johanna F; Bagdany, Miklos; Soya, Naoto; Xu, Haijin; Roldan, Ariel; Verkman, Alan S; Kurth, Mark; Simon, Agnes; Hegedus, Tamas; Beekman, Jeffrey M; Lukacs, Gergely L Nature chemical biology 23666117 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23666117
New route to the ergoline skeleton via cyclization of 4-unsubstituted indoles. Burley, Scott D; Lam, Vicky V; Lakner, Frederick J; Bergdahl, B Mikael; Parker, Matthew A Organic letters 23659323 2013 Jun 7 https://www.ncbi.nlm.nih.gov/pubmed/23659323
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LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Xu, Wei; Chooi, Yit-Heng; Choi, Jin W; Li, Shuang; Vederas, John C; Da Silva, Nancy A; Tang, Yi Angewandte Chemie (International ed. in English) 23653178 2013 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/23653178
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Tricycles by a new ugi variation and pictet-spengler reaction in one pot. Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, Alexander Chemistry (Weinheim an der Bergstrasse, Germany) 23649922 2013 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/23649922
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Coombs, Thomas C; Tanega, Cordelle; Shen, Min; Wang, Jenna L; Auld, Douglas S; Gerritz, Samuel W; Schoenen, Frank J; Thomas, Craig J; Aube, Jeffrey Bioorganic & medicinal chemistry letters 23642479 2013 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/23642479
High-Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor. Conn, P Michael; Smith, Emery; Hodder, Peter; Janovick, Jo Ann; Smithson, David C Journal of biomolecular screening 23640875 2013 May 2 https://www.ncbi.nlm.nih.gov/pubmed/23640875
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Engers, Darren W; Frist, Audrey Y; Lindsley, Craig W; Hong, Charles C; Hopkins, Corey R Bioorganic & medicinal chemistry letters 23639540 2013 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/23639540
An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. Leung, Chi K; Wang, Ying; Malany, Siobhan; Deonarine, Andrew; Nguyen, Kevin; Vasile, Stefan; Choe, Keith P PloS one 23637990 2013 https://www.ncbi.nlm.nih.gov/pubmed/23637990
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Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation. Panarese, Joseph D; Konkol, Leah C; Berry, Cynthia B; Bates, Brittney S; Aldrich, Leslie N; Lindsley, Craig W Tetrahedron letters 23606772 2013 May 1 https://www.ncbi.nlm.nih.gov/pubmed/23606772
A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dabir, Deepa V; Hasson, Samuel A; Setoguchi, Kiyoko; Johnson, Meghan E; Wongkongkathep, Piriya; Douglas, Colin J; Zimmerman, Johannes; Damoiseaux, Robert; Teitell, Michael A; Koehler, Carla M Developmental cell 23597483 2013 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/23597483
Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. Cheng, Bokun; Cao, Shugeng; Vasquez, Victor; Annamalai, Thirunavukkarasu; Tamayo-Castillo, Giselle; Clardy, Jon; Tse-Dinh, Yuk-Ching PloS one 23593306 2013 https://www.ncbi.nlm.nih.gov/pubmed/23593306
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening. Thomas, Pei W; Spicer, Timothy; Cammarata, Michael; Brodbelt, Jennifer S; Hodder, Peter; Fast, Walter Bioorganic & medicinal chemistry 23591260 2013 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/23591260
A small molecule inhibitor of fungal histone acetyltransferase Rtt109. Lopes da Rosa, Jessica; Bajaj, Vineeta; Spoonamore, James; Kaufman, Paul D Bioorganic & medicinal chemistry letters 23587423 2013 May 15 https://www.ncbi.nlm.nih.gov/pubmed/23587423
An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. Mulrooney, Carol A; Lahr, David L; Quintin, Michael J; Youngsaye, Willmen; Moccia, Dennis; Asiedu, Jacob K; Mulligan, Evan L; Akella, Lakshmi B; Marcaurelle, Lisa A; Montgomery, Philip; Bittker, Joshua A; Clemons, Paul A; Brudz, Stephen; Dandapani, Sivara Journal of computer-aided molecular design 23585218 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23585218
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Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. Karapetyan, Yervand Eduard; Sferrazza, Gian Franco; Zhou, Minghai; Ottenberg, Gregory; Spicer, Timothy; Chase, Peter; Fallahi, Mohammad; Hodder, Peter; Weissmann, Charles; Lasmezas, Corinne Ida Proceedings of the National Academy of Sciences of the United States of America 23576755 2013 Apr 23 https://www.ncbi.nlm.nih.gov/pubmed/23576755
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Discovery of BRM Targeted Therapies: Novel Reactivation of an Anti-cancer Gene. Gramling, Sarah; Reisman, David Letters in drug design & discovery 23565070 2011 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/23565070
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Hu, Longqin; Magesh, Sadagopan; Chen, Lin; Wang, Lili; Lewis, Timothy A; Chen, Yu; Khodier, Carol; Inoyama, Daigo; Beamer, Lesa J; Emge, Thomas J; Shen, Jian; Kerrigan, John E; Kong, Ah-Ng Tony; Dandapani, Sivaraman; Palmer, Michelle; Schreiber, Stuart L; Bioorganic & medicinal chemistry letters 23562243 2013 May 15 https://www.ncbi.nlm.nih.gov/pubmed/23562243
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Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones. Coffman, Keith C; Palazzo, Teresa A; Hartley, Timothy P; Fettinger, James C; Tantillo, Dean J; Kurth, Mark J Organic letters 23557405 2013 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/23557405
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Identification of small molecules that inhibit the interaction of TEM8 with anthrax protective antigen using a FRET assay. Cryan, Lorna M; Habeshian, Kaiane A; Caldwell, Thomas P; Morris, Meredith T; Ackroyd, P Christine; Christensen, Kenneth A; Rogers, Michael S Journal of biomolecular screening 23479355 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23479355
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Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes. Dubrovskiy, Anton V; Jain, Prashi; Shi, Feng; Lushington, Gerald H; Santini, Conrad; Porubsky, Patrick; Larock, Richard C ACS combinatorial science 23472819 2013 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/23472819
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters. Strouse, J Jacob; Ivnitski-Steele, Irena; Waller, Anna; Young, Susan M; Perez, Dominique; Evangelisti, Annette M; Ursu, Oleg; Bologa, Cristian G; Carter, Mark B; Salas, Virginia M; Tegos, George; Larson, Richard S; Oprea, Tudor I; Edwards, Bruce S; Sklar, Analytical biochemistry 23470221 2013 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/23470221
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Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model. Chibebe Junior, Jose; Fuchs, Beth B; Sabino, Caetano P; Junqueira, Juliana C; Jorge, Antonio O C; Ribeiro, Martha S; Gilmore, Michael S; Rice, Louis B; Tegos, George P; Hamblin, Michael R; Mylonakis, Eleftherios PloS one 23457486 2013 https://www.ncbi.nlm.nih.gov/pubmed/23457486
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Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. O'Reilly, Matthew C; Scott, Sarah A; Brown, Kyle A; Oguin 3rd, Thomas H; Thomas, Paul G; Daniels, J Scott; Morrison, Ryan; Brown, H Alex; Lindsley, Craig W Journal of medicinal chemistry 23445448 2013 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/23445448
Probing the metabotropic glutamate receptor 5 (mGluýýý) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology. Gregory, Karen J; Nguyen, Elizabeth D; Reiff, Sean D; Squire, Emma F; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn, P Jeffrey Molecular pharmacology 23444015 2013 May https://www.ncbi.nlm.nih.gov/pubmed/23444015
Developing irreversible inhibitors of the protein kinase cysteinome. Liu, Qingsong; Sabnis, Yogesh; Zhao, Zheng; Zhang, Tinghu; Buhrlage, Sara J; Jones, Lyn H; Gray, Nathanael S Chemistry & biology 23438744 2013 Feb 21 https://www.ncbi.nlm.nih.gov/pubmed/23438744
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Welsbie, Derek S; Yang, Zhiyong; Ge, Yan; Mitchell, Katherine L; Zhou, Xinrong; Martin, Scott E; Berlinicke, Cynthia A; Hackler Jr, Laszlo; Fuller, John; Fu, Jie; Cao, Li-hui; Han, Bing; Auld, Douglas; Xue, Tian; Hirai, Syu-ichi; Germain, Lucie; Simard-Bisson, Caroline; Blouin, Richard; Nguyen, Judy V; Davis, Chung-ha O; Enke, Raymond A; Boye, Sanford L; Merbs, Shannath L; Marsh-Armstrong, Nicholas; Hauswirth, William W; DiAntonio, Aaron; Nickells, Robert W; Inglese, James; Hanes, Justin; Yau, King-Wai; Quigley, Harry A; Zack, Donald J Proceedings of the National Academy of Sciences of the United States of America 23431148 2013 Mar 5 https://www.ncbi.nlm.nih.gov/pubmed/23431148
Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Huang, Gang; Chen, Huabing; Dong, Ying; Luo, Xiuquan; Yu, Haijun; Moore, Zachary; Bey, Erik A; Boothman, David A; Gao, Jinming Theranostics 23423156 2013 https://www.ncbi.nlm.nih.gov/pubmed/23423156
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule. Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R Bioorganic & medicinal chemistry letters 23416001 2013 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/23416001
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Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived claisen rearrangements. McIntosh, John A; Lin, Zhenjian; Tianero, Ma Diarey B; Schmidt, Eric W ACS chemical biology 23411099 2013 May 17 https://www.ncbi.nlm.nih.gov/pubmed/23411099
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Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Germain, Andrew R; Carmody, Leigh C; Nag, Partha P; Morgan, Barbara; Verplank, Lynn; Fernandez, Cristina; Donckele, Etienne; Feng, Yuxiong; Perez, Jose R; Dandapani, Sivaraman; Palmer, Michelle; Lander, Eric S; Gupta, Piyush B; Schreiber, Stuart L; Munoz, Bioorganic & medicinal chemistry letters 23403082 2013 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/23403082
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Parallel solution-phase synthesis of an adenosine antibiotic analog library. Moukha-chafiq, Omar; Reynolds, Robert C ACS combinatorial science 23398694 2013 Mar 11 https://www.ncbi.nlm.nih.gov/pubmed/23398694
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Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells. Sherman, Sean P; Pyle, April D PloS one 23383009 2013 https://www.ncbi.nlm.nih.gov/pubmed/23383009
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Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. Wikswo, John P; Block 3rd, Frank E; Cliffel, David E; Goodwin, Cody R; Marasco, Christina C; Markov, Dmitry A; McLean, David L; McLean, John A; McKenzie, Jennifer R; Reiserer, Ronald S; Samson, Philip C; Schaffer, David K; Seale, Kevin T; Sherrod, Stacy D IEEE transactions on bio-medical engineering 23380852 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23380852
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Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J. RNA Biol 23353574 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23353574
Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Emert-Sedlak, Lori A; Narute, Purushottam; Shu, Sherry T; Poe, Jerrod A; Shi, Haibin; Yanamala, Naveena; Alvarado, John Jeff; Lazo, John S; Yeh, Joanne I; Johnston, Paul A; Smithgall, Thomas E Chemistry & biology 23352142 2013 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/23352142
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanad Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; Jadhav, Ajit; Gileadi, Opher; Maloney, David J; Simeonov, Anton; Hickson, Ian D Chemistry & biology 23352139 2013 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/23352139
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Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. Salvador, Lilibeth A; Taori, Kanchan; Biggs, Jason S; Jakoncic, Jean; Ostrov, David A; Paul, Valerie J; Luesch, Hendrik Journal of medicinal chemistry 23350733 2013 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/23350733
Effect of virulence factors on the photodynamic inactivation of Cryptococcus neoformans. Prates, Renato A; Fuchs, Beth Burgwyn; Mizuno, Kazue; Naqvi, Qurat; Kato, Ilka T; Ribeiro, Martha S; Mylonakis, Eleftherios; Tegos, George P; Hamblin, Michael R PloS one 23349872 2013 https://www.ncbi.nlm.nih.gov/pubmed/23349872
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Noetzel, M J; Gregory, K J; Vinson, P N; Manka, J T; Stauffer, S R; Lindsley, C W; Niswender, C M; Xiang, Z; Conn, P J Molecular pharmacology 23348500 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23348500
High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. Titus SA, Southall N, Marugan J, Austin CP, Zheng W. Curr Chem Genomics 23346268 2012 https://www.ncbi.nlm.nih.gov/pubmed/23346268
A fast least-squares algorithm for population inference. Parry, R Mitchell; Wang, May D BMC bioinformatics 23343408 2013 https://www.ncbi.nlm.nih.gov/pubmed/23343408
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Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. Judson R, Kavlock R, Martin M, Reif D, Houck K, Knudsen T, Richard A, Tice RR, Whelan M, Xia M, Huang R, Austin C, Daston G, Hartung T, Fowle JR 3rd, Wooge W, Tong W, Dix D. ALTEX 23338806 2013 https://www.ncbi.nlm.nih.gov/pubmed/23338806
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Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. Haynes, Stuart W; Gao, Xue; Tang, Yi; Walsh, Christopher T ACS chemical biology 23330675 2013 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/23330675
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. Davis, Mindy I; Sasaki, Atsuo T; Shen, Min; Emerling, Brooke M; Thorne, Natasha; Michael, Sam; Pragani, Rajan; Boxer, Matthew; Sumita, Kazutaka; Takeuchi, Koh; Auld, Douglas S; Li, Zhuyin; Cantley, Lewis C; Simeonov, Anton PloS one 23326584 2013 https://www.ncbi.nlm.nih.gov/pubmed/23326584
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. Vamos, Mitchell; Welsh, Kate; Finlay, Darren; Lee, Pooi San; Mace, Peter D; Snipas, Scott J; Gonzalez, Monica L; Ganji, Santhi Reddy; Ardecky, Robert J; Riedl, Stefan J; Salvesen, Guy S; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D P ACS chemical biology 23323685 2013 Apr 19 https://www.ncbi.nlm.nih.gov/pubmed/23323685
Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. Chou, Tsui-Fen; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Deshaies, Raymond J ChemMedChem 23316025 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23316025
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Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Liang, Yu; Vogel, Jodi L; Arbuckle, Jesse H; Rai, Ganesha; Jadhav, Ajit; Simeonov, Anton; Maloney, David J; Kristie, Thomas M Science translational medicine 23303604 2013 Jan 9 https://www.ncbi.nlm.nih.gov/pubmed/23303604
A chemogenomic analysis of ionization constants--implications for drug discovery. Manallack, David T; Prankerd, Richard J; Nassta, Gemma C; Ursu, Oleg; Oprea, Tudor I; Chalmers, David K ChemMedChem 23303535 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23303535
A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Chung, Dong-Hoon; Moore, Blake P; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I; Ananthan, Subramaniam; White, E Lucile; Jia, Fuli; Jonsson, Colleen B; Severson, William E Virology journal 23302182 2013 https://www.ncbi.nlm.nih.gov/pubmed/23302182
Structural separations by ion mobility-MS for glycomics and glycoproteomics. Fenn, Larissa S; McLean, John A Methods in molecular biology (Clifton, N.J.) 23296531 2013 https://www.ncbi.nlm.nih.gov/pubmed/23296531
Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches. Hu, Xin; Vujanac, Milos; Southall, Noel; Stebbins, C Erec Bioorganic & medicinal chemistry letters 23294700 2013 Feb 15 https://www.ncbi.nlm.nih.gov/pubmed/23294700
Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression. Bar-Shir, Amnon; Liu, Guanshu; Liang, Yajie; Yadav, Nirbhay N; McMahon, Michael T; Walczak, Piotr; Nimmagadda, Sridhar; Pomper, Martin G; Tallman, Keri A; Greenberg, Marc M; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf A Journal of the American Chemical Society 23289583 2013 Jan 30 https://www.ncbi.nlm.nih.gov/pubmed/23289583
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Identification and characterization of small molecules as potent and specific EPAC2 antagonists. Chen, Haijun; Tsalkova, Tamara; Chepurny, Oleg G; Mei, Fang C; Holz, George G; Cheng, Xiaodong; Zhou, Jia Journal of medicinal chemistry 23286832 2013 Feb 14 https://www.ncbi.nlm.nih.gov/pubmed/23286832
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Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors. Duveau, Damien Y; Hu, Xin; Walsh, Martin J; Shukla, Suneet; Skoumbourdis, Amanda P; Boxer, Matthew B; Ambudkar, Suresh V; Shen, Min; Thomas, Craig J Bioorganic & medicinal chemistry letters 23273517 2013 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/23273517
Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Sedykh, Alexander; Fourches, Denis; Duan, Jianmin; Hucke, Oliver; Garneau, Michel; Zhu, Hao; Bonneau, Pierre; Tropsha, Alexander Pharmaceutical research 23269503 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23269503
Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. Nguyen, Huy H; Kurth, Mark J Organic letters 23268775 2013 Jan 18 https://www.ncbi.nlm.nih.gov/pubmed/23268775
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Nagano, Joseph M G; Hsu, Ku-Lung; Whitby, Landon R; Niphakis, Micah J; Speers, Anna E; Brown, Steven J; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter; Srinivasan, Prabhavathi; Gonzalez, Tara D; Rosen, Hugh; Bahnson, Brian J; Cra Bioorganic & medicinal chemistry letters 23260346 2013 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/23260346
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. Digby, Gregory J; Utley, Thomas J; Lamsal, Atin; Sevel, Christian; Sheffler, Douglas J; Lebois, Evan P; Bridges, Thomas M; Wood, Michael R; Niswender, Colleen M; Lindsley, Craig W; Conn, P Jeffrey ACS chemical neuroscience 23259038 2012 Dec 19 https://www.ncbi.nlm.nih.gov/pubmed/23259038
Adapting human pluripotent stem cells to high-throughput and high-content screening. Desbordes, Sabrina C; Studer, Lorenz Nature protocols 23257981 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23257981
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Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants. Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing PloS one 23251633 2012 https://www.ncbi.nlm.nih.gov/pubmed/23251633
Bactobolin resistance is conferred by mutations in the L2 ribosomal protein. Chandler, Josephine R; Truong, Thao T; Silva, Patricia M; Seyedsayamdost, Mohammad R; Carr, Gavin; Radey, Matthew; Jacobs, Michael A; Sims, Elizabeth H; Clardy, Jon; Greenberg, E Peter mBio 23249812 2012 https://www.ncbi.nlm.nih.gov/pubmed/23249812
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Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. Guo, Yirui; Partch, Carrie L; Key, Jason; Card, Paul B; Pashkov, Victor; Patel, Anjana; Bruick, Richard K; Wurdak, Heiko; Gardner, Kevin H ACS chemical biology 23240775 2013 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/23240775
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Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL pr Jacobs, Jon; Grum-Tokars, Valerie; Zhou, Ya; Turlington, Mark; Saldanha, S Adrian; Chase, Peter; Eggler, Aimee; Dawson, Eric S; Baez-Santos, Yahira M; Tomar, Sakshi; Mielech, Anna M; Baker, Susan C; Lindsley, Craig W; Hodder, Peter; Mesecar, Andrew; Stauf Journal of medicinal chemistry 23231439 2013 Jan 24 https://www.ncbi.nlm.nih.gov/pubmed/23231439
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A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Johnson, Barry C; Pauly, Gary T; Rai, Ganesha; Patel, Disha; Bauman, Joseph D; Baker, Heather L; Das, Kalyan; Schneider, Joel P; Maloney, David J; Arnold, Eddy; Thomas, Craig J; Hughes, Stephen H Retrovirology 23217210 2012 https://www.ncbi.nlm.nih.gov/pubmed/23217210
Identification of Small-Molecule Agonists of Human Relaxin Family Receptor 1 (RXFP1) by Using a Homogenous Cell-Based cAMP Assay. Chen CZ, Southall N, Xiao J, Marugan JJ, Ferrer M, Hu X, Jones RE, Feng S, Agoulnik IU, Zheng W, Agoulnik AI. J Biomol Screen 23212924 2013 Jul https://www.ncbi.nlm.nih.gov/pubmed/23212924
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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169. Tarr, James C; Turlington, Mark L; Reid, Paul R; Utley, Thomas J; Sheffler, Douglas J; Cho, Hyekyung P; Klar, Rebecca; Pancani, Tristano; Klein, Michael T; Bridges, Thomas M; Morrison, Ryan D; Blobaum, Anna L; Xiang, Zixui; Daniels, J Scott; Niswender, Co ACS chemical neuroscience 23173069 2012 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/23173069
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Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. Montaser, Rana; Paul, Valerie J; Luesch, Hendrik Chembiochem : a European journal of chemical biology 23143757 2012 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/23143757
Discovery and SAR of a novel series of non-MPEP site mGluýýý PAMs based on an aryl glycine sulfonamide scaffold. Rodriguez, Alice L; Zhou, Ya; Williams, Richard; David Weaver, C; Vinson, Paige N; Dawson, Eric S; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolome, Jose M; Macdonald, Gregor J; Scott Daniels, J; Niswender, Colleen M; Jones, Carrie K; Jeffrey Bioorganic & medicinal chemistry letters 23142615 2012 Dec 15 https://www.ncbi.nlm.nih.gov/pubmed/23142615
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A high-throughput screening assay using Krabbe disease patient cells. Ribbens, Jameson; Whiteley, Grace; Furuya, Hirokazu; Southall, Noel; Hu, Xin; Marugan, Juan; Ferrer, Marc; Maegawa, Gustavo H B Analytical biochemistry 23138179 2013 Mar 1 https://www.ncbi.nlm.nih.gov/pubmed/23138179
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ. Antimicrob Agents Chemother 23129054 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23129054
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Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011). Deng, Xianming; Choi, Hwan Geun; Buhrlage, Sara J; Gray, Nathanael S Expert opinion on therapeutic patents 23126385 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/23126385
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Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection. Dorjsuren, Dorjbal; Kim, Daemyung; Vyjayanti, Vaddadi N; Maloney, David J; Jadhav, Ajit; Wilson 3rd, David M; Simeonov, Anton PloS one 23110144 2012 https://www.ncbi.nlm.nih.gov/pubmed/23110144
In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts. Guo, Jianxia; Clausen, Dana M; Beumer, Jan H; Parise, Robert A; Egorin, Merrill J; Bravo-Altamirano, Karla; Wipf, Peter; Sharlow, Elizabeth R; Wang, Qiming Jane; Eiseman, Julie L Cancer chemotherapy and pharmacology 23108699 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23108699
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In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear Receptor NR2E3. Qin, Qiong; Knapinska, Anna; Dobri, Nicoleta; Madoux, Franck; Chase, Peter; Hodder, Peter; Petrukhin, Konstantin Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 23098562 2013 Apr https://www.ncbi.nlm.nih.gov/pubmed/23098562
Compact quantum dots for single-molecule imaging. Smith, Andrew M; Nie, Shuming Journal of visualized experiments : JoVE 23093375 2012 https://www.ncbi.nlm.nih.gov/pubmed/23093375
The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles. Haddadin, Makhluf J; Conrad, Wayne E; Kurth, Mark J Mini reviews in medicinal chemistry 23092440 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/23092440
Discovery of small molecule fusion inhibitors targeting HIV-1 gp41. Zhou, Guangyan; Chu, Shidong Current pharmaceutical design 23092284 2013 https://www.ncbi.nlm.nih.gov/pubmed/23092284
Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches. Lynch, Caitlin; Pan, Yongmei; Li, Linhao; Ferguson, Stephen S; Xia, Menghang; Swaan, Peter W; Wang, Hongbing Pharmaceutical research 23090669 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/23090669
Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy. Williamson, Elizabeth A; Damiani, Leah; Leitao, Andrei; Hu, Chelin; Hathaway, Helen; Oprea, Tudor; Sklar, Larry; Shaheen, Montaser; Bauman, Julie; Wang, Wei; Nickoloff, Jac A; Lee, Suk-Hee; Hromas, Robert Cancer research 23090115 2012 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/23090115
Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. Kim, Yong Wook; Niphakis, Micah J; Georg, Gunda I The Journal of organic chemistry 23088256 2012 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/23088256
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Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Seyedsayamdost, Mohammad R; Traxler, Matthew F; Clardy, Jon; Kolter, Roberto Methods in enzymology 23084935 2012 https://www.ncbi.nlm.nih.gov/pubmed/23084935
Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design. Custodi, Chiara; Nuti, Roberto; Oprea, Tudor I; Macchiarulo, Antonio Journal of molecular graphics & modelling 23079642 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/23079642
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Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells. Le Marchand, Sylvain J; Piston, David W PloS one 23077547 2012 https://www.ncbi.nlm.nih.gov/pubmed/23077547
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase ýý. Yamanaka, Kinrin; Dorjsuren, Dorjbal; Eoff, Robert L; Egli, Martin; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Lloyd, R Stephen PloS one 23056190 2012 https://www.ncbi.nlm.nih.gov/pubmed/23056190
Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS. Environ Health Perspect 23052129 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/23052129
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Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. Zheng, Weihong; Ibanez, Glorymar; Wu, Hong; Blum, Gil; Zeng, Hong; Dong, Aiping; Li, Fengling; Hajian, Taraneh; Allali-Hassani, Abdellah; Amaya, Maria F; Siarheyeva, Alena; Yu, Wenyu; Brown, Peter J; Schapira, Matthieu; Vedadi, Masoud; Min, Jinrong; Luo, Journal of the American Chemical Society 23043551 2012 Oct 31 https://www.ncbi.nlm.nih.gov/pubmed/23043551
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. Moore, Blake P; Chung, Dong Hoon; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Noah, James W; Sosa, Melinda I; Ananthan, Subramaniam; Tower, Nichole A; White, E Lucile; Jia, Fuli; Prisinzano, Thomas E; Aube, Jeffrey; Jonsson, C Journal of medicinal chemistry 23043370 2012 Oct 25 https://www.ncbi.nlm.nih.gov/pubmed/23043370
A torquoselective 6ýý electrocyclization approach to reserpine alkaloids. Barcan, Gregg A; Patel, Ashay; Houk, K N; Kwon, Ohyun Organic letters 23039026 2012 Nov 2 https://www.ncbi.nlm.nih.gov/pubmed/23039026
Assay Development Guidelines for Image-Based High Content Screening, High Content Analysis and High Content Imaging. Buchser W, Collins M, Garyantes T, Guha R, Haney S, Lemmon V, Li Z, Trask OJ. Assay Guidance Manual 23035272 2012 Oct 01 https://www.ncbi.nlm.nih.gov/pubmed/23035272
ýý-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. Xu, Miao; Liu, Ke; Swaroop, Manju; Porter, Forbes D; Sidhu, Rohini; Firnkes, Sally; Finkes, Sally; Ory, Daniel S; Marugan, Juan J; Xiao, Jingbo; Southall, Noel; Pavan, William J; Davidson, Cristin; Walkley, Steven U; Remaley, Alan T; Baxa, Ulrich; Sun, Wei; McKew, John C; Austin, Christopher P; Zheng, Wei The Journal of biological chemistry 23035117 2012 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/23035117
Identification and characterization of a compound that protects cardiac tissue from human Ether-a-go-go-related gene (hERG)-related drug-induced arrhythmias. Potet, Franck; Lorinc, Amanda N; Chaigne, Sebastien; Hopkins, Corey R; Venkataraman, Raghav; Stepanovic, Svetlana Z; Lewis, L Michelle; Days, Emily; Sidorov, Veniamin Y; Engers, Darren W; Zou, Beiyan; Afshartous, David; George Jr, Alfred L; Campbell, Cour The Journal of biological chemistry 23033485 2012 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/23033485
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. Haynes, Stuart W; Gao, Xue; Tang, Yi; Walsh, Christopher T Journal of the American Chemical Society 23030663 2012 Oct 24 https://www.ncbi.nlm.nih.gov/pubmed/23030663
High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding. Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A. PLoS One 23029124 2012 https://www.ncbi.nlm.nih.gov/pubmed/23029124
Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Carr, Gavin; Derbyshire, Emily R; Caldera, Eric; Currie, Cameron R; Clardy, Jon Journal of natural products 23025282 2012 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/23025282
MRI biosensor for protein kinase A encoded by a single synthetic gene. Airan, Raag D; Bar-Shir, Amnon; Liu, Guanshu; Pelled, Galit; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf A Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 23023588 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/23023588
Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. Preuss, Janina; Richardson, Adam D; Pinkerton, Anthony; Hedrick, Michael; Sergienko, Eduard; Rahlfs, Stefan; Becker, Katja; Bode, Lars Journal of biomolecular screening 23023104 2013 Mar https://www.ncbi.nlm.nih.gov/pubmed/23023104
Exploring chemical diversity via a modular reaction pairing strategy. Loh, Joanna K; Yoon, Sun Young; Samarakoon, Thiwanka B; Rolfe, Alan; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Hanson, Paul R Beilstein journal of organic chemistry 23019462 2012 https://www.ncbi.nlm.nih.gov/pubmed/23019462
A coincidence reporter-gene system for high-throughput screening. Cheng KC, Inglese J. Nat Methods 23018994 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/23018994
Briareolate esters from the gorgonian Briareum asbestinum. Meginley, Rian J; Gupta, Prasoon; Schulz, Thomas C; McLean, Amanda B; Robins, Allan J; West, Lyndon M Marine drugs 23015768 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/23015768
Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics. Kong, Koon Yin; Marcus, Adam I; Giannakakou, Paraskevi; Wang, May Dongmei International journal of computational biology and drug design 23013655 2012 https://www.ncbi.nlm.nih.gov/pubmed/23013655
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Nayar, Ribhu; Enos, Megan; Prince, Amanda; Shin, Hyunmu; Hemmers, Saskia; Jiang, Jian-kang; Klein, Ulf; Thomas, Craig J; Berg, Leslie J Proceedings of the National Academy of Sciences of the United States of America 23011795 2012 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/23011795
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Maloney, Patrick R; Khan, Pasha; Hedrick, Michael; Gosalia, Palak; Milewski, Monika; Li, Linda; Roth, Gregory P; Sergienko, Eduard; Suyama, Eigo; Sugarman, Eliot; Nguyen, Kevin; Mehta, Alka; Vasile, Stefan; Su, Ying; Stonich, Derek; Nguyen, Hung; Zeng, Fu Bioorganic & medicinal chemistry letters 23010269 2012 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/23010269
Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Knapp, John M; Zhu, Jie S; Tantillo, Dean J; Kurth, Mark J Angewandte Chemie (International ed. in English) 23001913 2012 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/23001913
Rapidly relocating molecules between organelles to manipulate small GTPase activity. Phua, Siew Cheng; Pohlmeyer, Christopher; Inoue, Takanari ACS chemical biology 22999378 2012 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/22999378
Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases. Smanski, Michael J; Peterson, Ryan M; Shen, Ben Methods in enzymology 22999174 2012 https://www.ncbi.nlm.nih.gov/pubmed/22999174
Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. J Transl Med 22999104 2012 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/22999104
Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Cacho, Ralph A; Jiang, Wei; Chooi, Yit-Heng; Walsh, Christopher T; Tang, Yi Journal of the American Chemical Society 22998630 2012 Oct 10 https://www.ncbi.nlm.nih.gov/pubmed/22998630
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Huang, Fen; Zhang, Hongkang; Wu, Meng; Yang, Huanghe; Kudo, Makoto; Peters, Christian J; Woodruff, Prescott G; Solberg, Owen D; Donne, Matthew L; Huang, Xiaozhu; Sheppard, Dean; Fahy, John V; Wolters, Paul J; Hogan, Brigid L M; Finkbeiner, Walter E; Li, M Proceedings of the National Academy of Sciences of the United States of America 22988107 2012 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/22988107
Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds. Tomasini-Johansson, Bianca R; Johnson, Ian A; Hoffmann, F Michael; Mosher, Deane F Matrix biology : journal of the International Society for Matrix Biology 22986508 2012 Jul https://www.ncbi.nlm.nih.gov/pubmed/22986508
Structure and biosynthesis of the antibiotic bottromycin D. Hou, Yanpeng; Tianero, Ma Diarey B; Kwan, Jason C; Wyche, Thomas P; Michel, Cole R; Ellis, Gregory A; Vazquez-Rivera, Emmanuel; Braun, Doug R; Rose, Warren E; Schmidt, Eric W; Bugni, Tim S Organic letters 22984777 2012 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/22984777
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. Sirenko, Oksana; Crittenden, Carole; Callamaras, Nick; Hesley, Jayne; Chen, Yen-Wen; Funes, Carlos; Rusyn, Ivan; Anson, Blake; Cromwell, Evan F Journal of biomolecular screening 22972846 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/22972846
Novel selective allosteric and bitopic ligands for the S1P(3) receptor. Jo, Euijung; Bhhatarai, Barun; Repetto, Emanuela; Guerrero, Miguel; Riley, Sean; Brown, Steven J; Kohno, Yasushi; Roberts, Edward; Schurer, Stephan C; Rosen, Hugh ACS chemical biology 22971058 2012 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/22971058
Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. Khoury, Kareem; Sinha, Mantosh K; Nagashima, Tadamichi; Herdtweck, Eberhardt; Domling, Alexander Angewandte Chemie (International ed. in English) 22968839 2012 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/22968839
A dual-column solid phase extraction strategy for online collection and preparation of continuously flowing effluent streams for mass spectrometry. Enders, Jeffrey R; Marasco, Christina C; Wikswo, John P; McLean, John A Analytical chemistry 22967262 2012 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/22967262
New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Kron, Michael; Shen, Ben Organic letters 22967068 2012 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/22967068
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, A Nature structural & molecular biology 22961382 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22961382
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Small molecule inhibitors of RORýýt: targeting Th17 cells and other applications. Huh, Jun R; Littman, Dan R European journal of immunology 22949321 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22949321
Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Pouliot, Lynn M; Chen, Yu-Chi; Bai, Jennifer; Guha, Rajarshi; Martin, Scott E; Gottesman, Michael M; Hall, Matthew D Cancer research 22942255 2012 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/22942255
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. Ndjomou, Jean; Kolli, Rajesh; Mukherjee, Sourav; Shadrick, William R; Hanson, Alicia M; Sweeney, Noreena L; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David N Antiviral research 22940425 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22940425
Navigating the fungal polyketide chemical space: from genes to molecules. Chooi, Yit-Heng; Tang, Yi The Journal of organic chemistry 22938194 2012 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/22938194
Interspecies modulation of bacterial development through iron competition and siderophore piracy. Traxler, Matthew F; Seyedsayamdost, Mohammad R; Clardy, Jon; Kolter, Roberto Molecular microbiology 22931126 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22931126
Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination? Dai, Tianhong; Murray, Clinton K; Vrahas, Mark S; Baer, David G; Tegos, George P; Hamblin, Michael R The journal of trauma and acute care surgery 22929495 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22929495
Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Tebbets, Brad; Yu, Zhiguo; Stewart, Douglas; Zhao, Li-Xing; Jiang, Yi; Xu, Li-Hua; Andes, David; Shen, Ben; Klein, Bruce Medical mycology : official publication of the International Society for Human and Animal Mycology 22928922 2012 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/22928922
One-pot phosphine-catalyzed syntheses of quinolines. Khong, San; Kwon, Ohyun The Journal of organic chemistry 22928667 2012 Sep 21 https://www.ncbi.nlm.nih.gov/pubmed/22928667
A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells. Mathews, Lesley A; Keller, Jonathan M; Goodwin, Bonnie L; Guha, Rajarshi; Shinn, Paul; Mull, Rebecca; Thomas, Craig J; de Kluyver, Rachel L; Sayers, Thomas J; Ferrer, Marc Journal of biomolecular screening 22927676 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22927676
High throughput measurement of Caýýýýý dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry. Cerignoli, Fabio; Charlot, David; Whittaker, Ross; Ingermanson, Randy; Gehalot, Piyush; Savchenko, Alex; Gallacher, David J; Towart, Rob; Price, Jeffrey H; McDonough, Patrick M; Mercola, Mark Journal of pharmacological and toxicological methods 22926323 2012 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/22926323
Stereoselective synthesis of acortatarins A and B. Wurst, Jacqueline M; Verano, Alyssa L; Tan, Derek S Organic letters 22924668 2012 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/22924668
Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. Boudreau, Paul D; Byrum, Tara; Liu, Wei-Ting; Dorrestein, Pieter C; Gerwick, William H Journal of natural products 22924493 2012 Sep 28 https://www.ncbi.nlm.nih.gov/pubmed/22924493
Synthesis of Tetrazolo-Fused Benzodiazepines and Benzodiazepinones by a Two-Step Protocol Using an Ugi-Azide Reaction for Initial Diversity Generation. Gunawan, Steven; Ayaz, Muhammad; De Moliner, Fabio; Frett, Brendan; Kaiser, Christine; Patrick, Nina; Xu, Zhigang; Hulme, Christopher Tetrahedron 22923851 2012 Jul 8 https://www.ncbi.nlm.nih.gov/pubmed/22923851
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. Strouse, J Jacob; Ivnitski-Steele, Irena; Khawaja, Hadya M; Perez, Dominique; Ricci, Jerec; Yao, Tuanli; Weiner, Warren S; Schroeder, Chad E; Simpson, Denise S; Maki, Brooks E; Li, Kelin; Golden, Jennifer E; Foutz, Terry D; Waller, Anna; Evangelisti, Anne Journal of biomolecular screening 22923785 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/22923785
Activation of the ATM-Snail pathway promotes breast cancer metastasis. Sun, Mianen; Guo, Xiaojing; Qian, Xiaolong; Wang, Haibo; Yang, Chunying; Brinkman, Kathryn L; Serrano-Gonzalez, Monica; Jope, Richard S; Zhou, Binhua; Engler, David A; Zhan, Ming; Wong, Stephen T C; Fu, Li; Xu, Bo Journal of molecular cell biology 22923499 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22923499
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin Nature chemical biology 22922757 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22922757
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin D; Malstrom, Scott; Khan, Tahsin M; Kung, Charles; Skoumbourdis, Amanda P; Veith, Henrike; Southall, Noel; Walsh, Martin J; Brimacombe, Kyle R; Leister, William; Lunt, Sophia Y; Johnson, Zachary R; Yen, Katharine E; Kunii, Kaiko; Davidson, Shawn M; Christofk, Heather R; Austin, Christopher P; Inglese, James; Harris, Marian H; Asara, John M; Stephanopoulos, Gregory; Salituro, Francesco G; Jin, Shengfang; Dang, Lenny; Auld, Douglas S; Park, Hee-Won; Cantley, Lewis C; Thomas, Craig J; Vander Heiden, Matthew G Nature chemical biology 22922757 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22922757
Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Thorne, Natasha; Shen, Min; Lea, Wendy A; Simeonov, Anton; Lovell, Scott; Auld, Douglas S; Inglese, James Chemistry & biology 22921073 2012 Aug 24 https://www.ncbi.nlm.nih.gov/pubmed/22921073
Total synthesis of (ýý)-hirsutine: application of phosphine-catalyzed imine-allene [4 + 2] annulation. Villa, Reymundo A; Xu, Qihai; Kwon, Ohyun Organic letters 22920858 2012 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/22920858
Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysis. O'Reilly, Matthew C; Lindsley, Craig W Tetrahedron letters 22919116 2012 Mar 28 https://www.ncbi.nlm.nih.gov/pubmed/22919116
Cyclosporine A and bromocriptine attenuate cell death mediated by intracellular calcium mobilization. Kim, In Ki; Park, So Jung; Park, Jhang Ho; Lee, Seung-Ho; Hong, Sung Eun; Reed, John C BMB reports 22917034 2012 Aug https://www.ncbi.nlm.nih.gov/pubmed/22917034
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFýý interaction. Cunningham, Lea; Finckbeiner, Steven; Hyde, R Katherine; Southall, Noel; Marugan, Juan; Yedavalli, Venkat R K; Dehdashti, Seameen Jean; Reinhold, William C; Alemu, Lemlem; Zhao, Ling; Yeh, Jing-Ruey Joanna; Sood, Raman; Pommier, Yves; Austin, Christopher P; Jeang, Kuan-Teh; Zheng, Wei; Liu, Paul Proceedings of the National Academy of Sciences of the United States of America 22912405 2012 Sep 4 https://www.ncbi.nlm.nih.gov/pubmed/22912405
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Mattmann, Margrith E; Yu, Haibo; Lin, Zhihong; Xu, Kaiping; Huang, Xiaofang; Long, Shunyou; Wu, Meng; McManus, Owen B; Engers, Darren W; Le, Uyen M; Li, Min; Lindsley, Craig W; Hopkins, Corey R Bioorganic & medicinal chemistry letters 22910039 2012 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/22910039
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase. Morgan, Hugh P; Walsh, Martin J; Blackburn, Elizabeth A; Wear, Martin A; Boxer, Matthew B; Shen, Min; Veith, Henrike; McNae, Iain W; Nowicki, Matthew W; Michels, Paul A M; Auld, Douglas S; Fothergill-Gilmore, Linda A; Walkinshaw, Malcolm D The Biochemical journal 22906073 2012 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/22906073
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Gao, Xue; Haynes, Stuart W; Ames, Brian D; Wang, Peng; Vien, Linda P; Walsh, Christopher T; Tang, Yi Nature chemical biology 22902615 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22902615
Bacterial pathogens commandeer rab GTPases to establish intracellular niches. Stein, Mary-Pat; Muller, Matthias P; Wandinger-Ness, Angela Traffic (Copenhagen, Denmark) 22901006 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/22901006
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Seguin, Sandlin P; Ireland, Alex W; Gupta, Tushar; Wright, Christine M; Miyata, Yoshinari; Wipf, Peter; Pipas, James M; Gestwicki, Jason E; Brodsky, Jeffrey L Antiviral research 22898086 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22898086
A suite of modular fluorescence assays interrogate the human immunodeficiency virus glycoprotein-41 coiled coil and assist in determining binding mechanism of low molecular weight fusion inhibitors. Gochin, Miriam Assay and drug development technologies 22897493 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22897493
Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Avila, Belem; Roth, Aaron; Streets, Heather; Dwyer, Donard S; Kurth, Mark J Bioorganic & medicinal chemistry letters 22892117 2012 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/22892117
Labeling of neuronal receptors and transporters with quantum dots. Chang, Jerry C; Kovtun, Oleg; Blakely, Randy D; Rosenthal, Sandra J Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 22887823 2012 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/22887823
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification. Kiffer-Moreira, Tina; Yadav, Manisha C; Zhu, Dongxing; Narisawa, Sonoko; Sheen, Campbell; Stec, Boguslaw; Cosford, Nicholas D; Dahl, Russell; Farquharson, Colin; Hoylaerts, Marc F; Macrae, Vicky E; Millan, Jose Luis Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 22887744 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/22887744
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Thal, David M; Homan, Kristoff T; Chen, Jun; Wu, Emily K; Hinkle, Patricia M; Huang, Z Maggie; Chuprun, J Kurt; Song, Jianliang; Gao, Erhe; Cheung, Joseph Y; Sklar, Larry A; Koch, Walter J; Tesmer, John J G ACS chemical biology 22882301 2012 Nov 16 https://www.ncbi.nlm.nih.gov/pubmed/22882301
Exploring uncharted territories: predicting activity cliffs in structure-activity landscapes. Guha, Rajarshi Journal of chemical information and modeling 22873578 2012 Aug 27 https://www.ncbi.nlm.nih.gov/pubmed/22873578
Biochemical analysis of protein SUMOylation. Alontaga, Aileen Y; Bobkova, Ekaterina; Chen, Yuan Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 22870855 2012 Jul https://www.ncbi.nlm.nih.gov/pubmed/22870855
Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Wu, Victoria M; Chen, Steven C; Arkin, Michelle R; Reiter, Jeremy F Proceedings of the National Academy of Sciences of the United States of America 22864913 2012 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/22864913
Challenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics. Xu X, Vugmeyster Y. AAPS J 22864668 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/22864668
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. Gregory, Karen J; Noetzel, Meredith J; Rook, Jerri M; Vinson, Paige N; Stauffer, Shaun R; Rodriguez, Alice L; Emmitte, Kyle A; Zhou, Ya; Chun, Aspen C; Felts, Andrew S; Chauder, Brian A; Lindsley, Craig W; Niswender, Colleen M; Conn, P Jeffrey Molecular pharmacology 22863693 2012 Nov https://www.ncbi.nlm.nih.gov/pubmed/22863693
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Reith, Alastair D; Bamborough, Paul; Jandu, Karamjit; Andreotti, Daniele; Mensah, Lucy; Dossang, Pamela; Choi, Hwan Geun; Deng, Xianming; Zhang, Jinwei; Alessi, Dario R; Gray, Nathanael S Bioorganic & medicinal chemistry letters 22863203 2012 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/22863203
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Wen, Qiang; Goldenson, Benjamin; Silver, Serena J; Schenone, Monica; Dancik, Vlado; Huang, Zan; Wang, Ling-Zhi; Lewis, Timothy A; An, W Frank; Li, Xiaoyu; Bray, Mark-Anthony; Thiollier, Clarisse; Diebold, Lauren; Gilles, Laure; Vokes, Martha S; Moore, Chr Cell 22863010 2012 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/22863010
Assembly of four diverse heterocyclic libraries enabled by Prins cyclization, Au-catalyzed enyne cycloisomerization, and automated amide synthesis. Cui, Jiayue; Chai, David I; Miller, Christopher; Hao, Jason; Thomas, Christopher; Wang, JingQi; Scheidt, Karl A; Kozmin, Sergey A The Journal of organic chemistry 22860634 2012 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/22860634
Expedient Synthesis of Norbenzomorphan Library via Multicomponent Assembly Process Coupled with Ring-Closing Reactions. Sahn, James J; Martin, Stephen F ACS combinatorial science 22857149 2012 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/22857149
Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy. Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R ACS combinatorial science 22853708 2012 Aug 13 https://www.ncbi.nlm.nih.gov/pubmed/22853708
Estimating the Lipophilicity of Natural Products using a Polymeric Reversed Phase HPLC Method. Zheng, Bo; West, Lyndon M Journal of liquid chromatography & related technologies 22851883 2009 https://www.ncbi.nlm.nih.gov/pubmed/22851883
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage. Yang, Chunying; Lee, Michael; Hao, Jianwei; Cui, Xiaoli; Guo, Xiaojing; Smal, Caroline; Bontemps, Francoise; Ma, Shumei; Liu, Xiaodong; Engler, David; Parker, William B; Xu, Bo Nucleic acids research 22850745 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22850745
Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target. Treger, R S; Cook, A G; Rai, G; Maloney, D J; Simeonov, A; Jadhav, A; Thomas, C J; Williams, D L; Cappello, M; Vermeire, J J International journal for parasitology, drugs and drug resistance 22844653 2012 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/22844653
Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring. Gerea, Alexandra L; Branscum, Katie M; King, Jarrod B; You, Jianlan; Powell, Douglas R; Miller, Andrew N; Spear, John R; Cichewicz, Robert H Tetrahedron letters 22844162 2012 Aug 8 https://www.ncbi.nlm.nih.gov/pubmed/22844162
Click-based synthesis of triazolobithiazole ýýF508-CFTR correctors for cystic fibrosis. Donald, Michael B; Rodriguez, Kevin X; Shay, Hannah; Phuan, Puay-Wah; Verkman, A S; Kurth, Mark J Bioorganic & medicinal chemistry 22841006 2012 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/22841006
Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. Bannwarth, Ludovic; Goldberg, Allison B; Chen, Catherine; Turk, Benjamin E Chemistry & biology 22840775 2012 Jul 27 https://www.ncbi.nlm.nih.gov/pubmed/22840775
Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ýýýýP and ýýýýC NMR spectroscopy. Jeffries, Rex E; Gamcsik, Michael P; Keshari, Kayvan R; Pediaditakis, Peter; Tikunov, Andrey P; Young, Gregory B; Lee, Haakil; Watkins, Paul B; Macdonald, Jeffrey M Tissue engineering. Part C, Methods 22835003 2013 Feb https://www.ncbi.nlm.nih.gov/pubmed/22835003
Discovery of a novel noniminosugar acid ýý glucosidase chaperone series. Xiao, Jingbo; Westbroek, Wendy; Motabar, Omid; Lea, Wendy A; Hu, Xin; Velayati, Arash; Zheng, Wei; Southall, Noel; Gustafson, Ann Marie; Goldin, Ehud; Sidransky, Ellen; Liu, Ke; Simeonov, Anton; Tamargo, Rafael J; Ribes, Antonia; Matalonga, Leslie; Ferrer, Marc; Marugan, Juan J Journal of medicinal chemistry 22834902 2012 Sep 13 https://www.ncbi.nlm.nih.gov/pubmed/22834902
Development and validation of a high-content screening assay to identify inhibitors of cytoplasmic Dynein-mediated transport of glucocorticoid receptor to the nucleus. Johnston, Paul A; Shinde, Sunita N; Hua, Yun; Shun, Tong Ying; Lazo, John S; Day, Billy W Assay and drug development technologies 22830992 2012 Oct https://www.ncbi.nlm.nih.gov/pubmed/22830992
Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. Seyedsayamdost, Mohammad R; Cleto, Sara; Carr, Gavin; Vlamakis, Hera; Joao Vieira, Maria; Kolter, Roberto; Clardy, Jon Journal of the American Chemical Society 22830960 2012 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/22830960
Drug repurposing: far beyond new targets for old drugs. Oprea, T I; Mestres, J The AAPS journal 22826034 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/22826034
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles. Conrad, Wayne E; Rodriguez, Kevin X; Nguyen, Huy H; Fettinger, James C; Haddadin, Makhluf J; Kurth, Mark J Organic letters 22823414 2012 Aug 3 https://www.ncbi.nlm.nih.gov/pubmed/22823414
Development of drugs for Epstein-Barr virus using high-throughput in silico virtual screening. Li, Ning; Thompson, Scott; Jiang, Hualiang; Lieberman, Paul M; Luo, Cheng Expert opinion on drug discovery 22822721 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/22822721
Plasma and tissue concentrations of ýý-tocopherol and ýý-tocopherol following high dose dietary supplementation in mice. Baxter, Laura L; Marugan, Juan J; Xiao, Jingbo; Incao, Art; McKew, John C; Zheng, Wei; Pavan, William J Nutrients 22822447 2012 Jun https://www.ncbi.nlm.nih.gov/pubmed/22822447
Synthesis and Biological Evaluation of Cremastrine and an Unnatural Analogue. Hahn, Kristopher N; Fadeyi, Olugbeminiyi O; Cho, Hyekyung P; Lindsley, Craig W Tetrahedron letters 22822275 2012 Jul 11 https://www.ncbi.nlm.nih.gov/pubmed/22822275
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Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. Krueger, Aaron B; Dehdashti, Seameen J; Southall, Noel; Marugan, Juan J; Ferrer, Marc; Li, Xueni; Ford, Heide L; Zheng, Wei; Zhao, Rui Journal of biomolecular screening 22820394 2013 Jan https://www.ncbi.nlm.nih.gov/pubmed/22820394
Development of 'DFG-out' inhibitors of gatekeeper mutant kinases. Choi, Hwan Geun; Zhang, Jianming; Weisberg, Ellen; Griffin, James D; Sim, Taebo; Gray, Nathanael S Bioorganic & medicinal chemistry letters 22819762 2012 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/22819762
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces paras Preuss, Janina; Maloney, Patrick; Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Gosalia, Palak; Milewski, Monika; Li, Yujie Linda; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Vasile, Stefan; Sergienko, Eduard; Mangravi Journal of medicinal chemistry 22813531 2012 Aug 23 https://www.ncbi.nlm.nih.gov/pubmed/22813531
Targeting iron assimilation to develop new antibacterials. Foley, Timothy L; Simeonov, Anton Expert opinion on drug discovery 22812521 2012 Sep https://www.ncbi.nlm.nih.gov/pubmed/22812521
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Absorption, distribution, metabolism, and excretion (ADME) studies of biotherapeutics for autoimmune and inflammatory conditions. Vugmeyster, Yulia; Harrold, John; Xu, Xin The AAPS journal 22798020 2012 Dec https://www.ncbi.nlm.nih.gov/pubmed/22798020
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, Cheung, Yiu-Yin; Yu, Haibo; Xu, Kaiping; Zou, Beiyan; Wu, Meng; McManus, Owen B; Li, Min; Lindsley, Craig W; Hopkins, Corey R Journal of medicinal chemistry 22793372 2012 Aug 9 https://www.ncbi.nlm.nih.gov/pubmed/22793372
Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2. Wang, Wei; Cao, Haiping; Wolf, Siglinde; Camacho-Horvitz, Miguel S; Holak, Tad A; Domling, Alexander Bioorganic & medicinal chemistry 22789708 2013 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/22789708
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Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype. Vidovic, Dusica; Xie, Yuli; Rinderspacher, Alison; Deng, Shi-Xian; Landry, Donald W; Chung, Caty; Smith, Deborah H; Tautz, Lutz; Schurer, Stephan C Journal of computer-aided molecular design 21904909 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21904909
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Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria. Tang, M; Odejinmi, S I; Allette, Y M; Vankayalapati, H; Lai, K Bioorganic & medicinal chemistry 21903402 2011 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/21903402
A brief survey of mRNA surveillance. van Hoof, Ambro; Wagner, Eric J Trends in biochemical sciences 21903397 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21903397
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. Rolfe, Alan; Ullah, Farman; Samarakoon, Thiwanka B; Kurtz, Ryan D; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R ACS combinatorial science 21902243 2011 Nov 14 https://www.ncbi.nlm.nih.gov/pubmed/21902243
Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm. Walsh, Kevin B; Teijaro, John R; Rosen, Hugh; Oldstone, Michael B A Immunologic research 21901448 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21901448
Optimization and application of median filter corrections to relieve diverse spatial patterns in microtiter plate data. Bushway, Paul J; Azimi, Behrad; Heynen-Genel, Susanne Journal of biomolecular screening 21900202 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21900202
Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. Tsuboi, Katsunori; Bachovchin, Daniel A; Speers, Anna E; Spicer, Timothy P; Fernandez-Vega, Virneliz; Hodder, Peter; Rosen, Hugh; Cravatt, Benjamin F Journal of the American Chemical Society 21899313 2011 Oct 19 https://www.ncbi.nlm.nih.gov/pubmed/21899313
A modular reaction pairing approach to the diversity-oriented synthesis of fused- and bridged-polycyclic sultams. Samarakoon, Thiwanka B; Loh, Joanna K; Rolfe, Alan; Le, Lisa S; Yoon, Sun Young; Lushington, Gerald H; Hanson, Paul R Organic letters 21899284 2011 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/21899284
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Ames, Brian D; Haynes, Stuart W; Gao, Xue; Evans, Bradley S; Kelleher, Neil L; Tang, Yi; Walsh, Christopher T Biochemistry 21899262 2011 Oct 11 https://www.ncbi.nlm.nih.gov/pubmed/21899262
Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion. Chamni, Supakarn; He, Qing-Li; Dang, Yongjun; Bhat, Shridhar; Liu, Jun O; Romo, Daniel ACS chemical biology 21894934 2011 Nov 18 https://www.ncbi.nlm.nih.gov/pubmed/21894934
Antidiabetic actions of a non-agonist PPARýý ligand blocking Cdk5-mediated phosphorylation. Choi, Jang Hyun; Banks, Alexander S; Kamenecka, Theodore M; Busby, Scott A; Chalmers, Michael J; Kumar, Naresh; Kuruvilla, Dana S; Shin, Youseung; He, Yuanjun; Bruning, John B; Marciano, David P; Cameron, Michael D; Laznik, Dina; Jurczak, Michael J; Schur Nature 21892191 2011 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/21892191
Nonomuraea soli sp. nov., an actinomycete isolated from soil. Cao, Yan-Ru; Jin, Rong-Xian; Jiang, Yi; He, Wen-Xiang; Jiang, Cheng-Lin International journal of systematic and evolutionary microbiology 21890732 2012 Jul https://www.ncbi.nlm.nih.gov/pubmed/21890732
Ligand-dependent perturbation of the conformational ensemble for the GPCR ýý2 adrenergic receptor revealed by HDX. West, Graham M; Chien, Ellen Y T; Katritch, Vsevolod; Gatchalian, Jovylyn; Chalmers, Michael J; Stevens, Raymond C; Griffin, Patrick R Structure (London, England : 1993) 21889352 2011 Oct 12 https://www.ncbi.nlm.nih.gov/pubmed/21889352
NRPS substrate promiscuity diversifies the xenematides. Crawford, Jason M; Portmann, Cyril; Kontnik, Renee; Walsh, Christopher T; Clardy, Jon Organic letters 21888371 2011 Oct 7 https://www.ncbi.nlm.nih.gov/pubmed/21888371
Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening. Bialkowska, Agnieszka B; Crisp, Melissa; Bannister, Thomas; He, Yuanjun; Chowdhury, Sarwat; Schurer, Stephan; Chase, Peter; Spicer, Timothy; Madoux, Franck; Tian, Chenlu; Hodder, Peter; Zaharevitz, Daniel; Yang, Vincent W Molecular cancer therapeutics 21885866 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21885866
The role of residue C410 on activation of the human vitamin D receptor by various ligands. Castillo, Hilda S; Ousley, Amanda M; Duraj-Thatte, Anna; Lindstrom, Kelli N; Patel, Dina D; Bommarius, Andreas S; Azizi, Bahareh The Journal of steroid biochemistry and molecular biology 21884792 2012 Jan https://www.ncbi.nlm.nih.gov/pubmed/21884792
Marine natural products: a new wave of drugs? Montaser, Rana; Luesch, Hendrik Future medicinal chemistry 21882941 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21882941
Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Dobretsov, Sergey; Teplitski, Max; Bayer, Mirko; Gunasekera, Sarath; Proksch, Peter; Paul, Valerie J Biofouling 21882898 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21882898
Rank order entropy: why one metric is not enough. McLellan, Margaret R; Ryan, M Dominic; Breneman, Curt M Journal of chemical information and modeling 21875058 2011 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/21875058
Evolution of secondary metabolite genes in three closely related marine actinomycete species. Freel, Kelle C; Nam, Sang-Jip; Fenical, William; Jensen, Paul R Applied and environmental microbiology 21873479 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21873479
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Zhao, Li-Xing; Huang, Sheng-Xiong; Tang, Shu-Kun; Jiang, Cheng-Lin; Duan, Yanwen; Beutler, John A; Henrich, Curtis J; McMahon, James B; Schmid, Tobias; Blees, Johanna S; Colburn, Nancy H; Rajski, Scott R; Shen, Ben Journal of natural products 21870828 2011 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/21870828
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an ýý-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. Li, Yanran; Chooi, Yit-Heng; Sheng, Yuewei; Valentine, Joan S; Tang, Yi Journal of the American Chemical Society 21866960 2011 Oct 5 https://www.ncbi.nlm.nih.gov/pubmed/21866960
Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery. Rolfe, Alan; Painter, Thomas O; Asad, Naeem; Hur, Moon Young; Jeon, Kyu Ok; Brzozowski, Marek; Klimberg, Sarra V; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Hanson, Paul R ACS combinatorial science 21866904 2011 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/21866904
Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Wang, Rui; Ibanez, Glorymar; Islam, Kabirul; Zheng, Weihong; Blum, Gil; Sengelaub, Caitlin; Luo, Minkui Molecular bioSystems 21866297 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21866297
Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. Fales, Andrew M; Yuan, Hsiangkuo; Vo-Dinh, Tuan Langmuir : the ACS journal of surfaces and colloids 21859159 2011 Oct 4 https://www.ncbi.nlm.nih.gov/pubmed/21859159
N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. Wencewicz, Timothy A; Yang, Baiyuan; Rudloff, James R; Oliver, Allen G; Miller, Marvin J Journal of medicinal chemistry 21859126 2011 Oct 13 https://www.ncbi.nlm.nih.gov/pubmed/21859126
Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems. Henrikson, Jon C; Ellis, Trevor K; King, Jarrod B; Cichewicz, Robert H Journal of natural products 21854017 2011 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/21854017
Cross-pharmacology analysis of G protein-coupled receptors. Brianso, Ferran; Carrascosa, Maria C; Oprea, Tudor I; Mestres, Jordi Current topics in medicinal chemistry 21851335 2011 https://www.ncbi.nlm.nih.gov/pubmed/21851335
Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Montaser, Rana; Paul, Valerie J; Luesch, Hendrik Phytochemistry 21843895 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21843895
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. Martin, S E; Wu, Z-H; Gehlhaus, K; Jones, T L; Zhang, Y-W; Guha, R; Miyamoto, S; Pommier, Y; Caplen, N J Current cancer drug targets 21834757 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21834757
Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. Tran, Hoang T; Zhang, Shuxing Journal of chemical information and modeling 21834588 2011 Sep 26 https://www.ncbi.nlm.nih.gov/pubmed/21834588
Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds. Granger, Brett A; Kaneda, Kyosuke; Martin, Stephen F Organic letters 21834504 2011 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/21834504
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1ýý inhibitors. Huang, Wenwei; Huang, Ruili; Attene-Ramos, Matias S; Sakamuru, Srilatha; Englund, Erika E; Inglese, James; Austin, Christopher P; Xia, Menghang Bioorganic & medicinal chemistry letters 21831635 2011 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/21831635
Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Knapp, John M; Fettinger, James C; Kurth, Mark J Organic letters 21827181 2011 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/21827181
7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. Kiselev, Evgeny; DeGuire, Sean; Morrell, Andrew; Agama, Keli; Dexheimer, Thomas S; Pommier, Yves; Cushman, Mark Journal of medicinal chemistry 21823606 2011 Sep 8 https://www.ncbi.nlm.nih.gov/pubmed/21823606
Human pluripotent stem cells: the development of high-content screening strategies. Sherman, Sean P; Alva, Jackelyn A; Thakore-Shah, Kaushali; Pyle, April D Methods in molecular biology (Clifton, N.J.) 21822883 2011 https://www.ncbi.nlm.nih.gov/pubmed/21822883
Imaging mass spectrometry in microbiology. Watrous, Jeramie D; Dorrestein, Pieter C Nature reviews. Microbiology 21822293 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21822293
Discovery, synthesis, and biological evaluation of novel SMN protein modulators. Xiao, Jingbo; Marugan, Juan J; Zheng, Wei; Titus, Steve; Southall, Noel; Cherry, Jonathan J; Evans, Matthew; Androphy, Elliot J; Austin, Christopher P Journal of medicinal chemistry 21819082 2011 Sep 22 https://www.ncbi.nlm.nih.gov/pubmed/21819082
BDDCS applied to over 900 drugs. Benet, Leslie Z; Broccatelli, Fabio; Oprea, Tudor I The AAPS journal 21818695 2011 Dec https://www.ncbi.nlm.nih.gov/pubmed/21818695
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Yuan, Jing; Cheng, Ken Chih-Chien; Johnson, Ronald L; Huang, Ruili; Pattaradilokrat, Sittiporn; Liu, Anna; Guha, Rajarshi; Fidock, David A; Inglese, James; Wellems, Thomas E; Austin, Christopher P; Su, Xin-zhuan Science (New York, N.Y.) 21817045 2011 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/21817045
Metal-free chlorodeboronation of organotrifluoroborates. Molander, Gary A; Cavalcanti, Livia N The Journal of organic chemistry 21812468 2011 Sep 2 https://www.ncbi.nlm.nih.gov/pubmed/21812468
Phosphine-catalyzed annulations of azomethine imines: allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways. Na, Risong; Jing, Chengfeng; Xu, Qihai; Jiang, Hui; Wu, Xi; Shi, Jiayan; Zhong, Jiangchun; Wang, Min; Benitez, Diego; Tkatchouk, Ekaterina; Goddard, William A; Guo, Hongchao; Kwon, Ohyun Journal of the American Chemical Society 21812448 2011 Aug 31 https://www.ncbi.nlm.nih.gov/pubmed/21812448
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Youngsaye, Willmen; Vincent, Benjamin; Hartland, Cathy L; Morgan, Barbara J; Buhrlage, Sara J; Johnston, Stephen; Bittker, Joshua A; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L; Muno Bioorganic & medicinal chemistry letters 21802942 2011 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/21802942
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick; Gray, Nathanael S Chemistry & biology 21802008 2011 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/21802008
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick Chemistry & biology 21802008 2011 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/21802008
Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Correa, Ricardo G; Khan, Pasha M; Askari, Nadav; Zhai, Dayong; Gerlic, Motti; Brown, Brock; Magnuson, Gavin; Spreafico, Roberto; Albani, Salvatore; Sergienko, Eduard; Diaz, Paul W; Roth, Gregory P; Reed, John C Chemistry & biology 21802003 2011 Jul 29 https://www.ncbi.nlm.nih.gov/pubmed/21802003
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. Miller, Melissa; Shi, Jie; Zhu, Yingmin; Kustov, Maksym; Tian, Jin-bin; Stevens, Amy; Wu, Meng; Xu, Jia; Long, Shunyou; Yang, Pu; Zholos, Alexander V; Salovich, James M; Weaver, C David; Hopkins, Corey R; Lindsley, Craig W; McManus, Owen; Li, Min; Zhu, Mi The Journal of biological chemistry 21795696 2011 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/21795696
SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1Pýýý) receptor. Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic & medicinal chemistry letters 21783362 2011 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/21783362
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. Dennis, Megan K; Field, Angela S; Burai, Ritwik; Ramesh, Chinnasamy; Petrie, Whitney K; Bologa, Cristian G; Oprea, Tudor I; Yamaguchi, Yuri; Hayashi, Shin-Ichi; Sklar, Larry A; Hathaway, Helen J; Arterburn, Jeffrey B; Prossnitz, Eric R The Journal of steroid biochemistry and molecular biology 21782022 2011 Nov https://www.ncbi.nlm.nih.gov/pubmed/21782022
Zeocin for selection of bleMX6 resistance in fission yeast. Benko, Zsigmond; Zhao, Richard Y BioTechniques 21781055 2011 Jul https://www.ncbi.nlm.nih.gov/pubmed/21781055
Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy. Lo, Kai-Yin; Sun, Yung-Shin; Landry, James P; Zhu, Xiangdong; Deng, Wenbin BioTechniques 21781038 2011 Jun https://www.ncbi.nlm.nih.gov/pubmed/21781038
Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A. Leighty, Matthew W; Georg, Gunda I ACS medicinal chemistry letters 21779519 2011 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/21779519
A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis. Grimes, Kimberly D; Aldrich, Courtney C Analytical biochemistry 21771578 2011 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/21771578
A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support. Li, Yangmei; Giulianotti, Marc; Houghten, Richard A Tetrahedron letters 21765557 2010 Oct 27 https://www.ncbi.nlm.nih.gov/pubmed/21765557
Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds. Choi, Jonghoon; Kim, Kyobum; Kim, Taeho; Liu, Guanshu; Bar-Shir, Amnon; Hyeon, Taeghwan; McMahon, Michael T; Bulte, Jeff W M; Fisher, John P; Gilad, Assaf A Journal of controlled release : official journal of the Controlled Release Society 21763735 2011 Dec 10 https://www.ncbi.nlm.nih.gov/pubmed/21763735
Sequencing cyclic peptides by multistage mass spectrometry. Mohimani, Hosein; Yang, Yu-Liang; Liu, Wei-Ting; Hsieh, Pei-Wen; Dorrestein, Pieter C; Pevzner, Pavel A Proteomics 21751357 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21751357
Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Brown, Lauren E; Dai, Peng; Porco Jr, John A; Schaus, Scott E Organic letters 21749159 2011 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/21749159
Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor. Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; Sherrer, Eric S; McLean, Amanda B; Robins, Allan J; West, Lyndon M Organic letters 21749084 2011 Aug 5 https://www.ncbi.nlm.nih.gov/pubmed/21749084
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches. Ekland, Eric H; Schneider, Jessica; Fidock, David A FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21746861 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21746861
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, Journal of medicinal chemistry 21739938 2011 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/21739938
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, David J; Holman, Theodore R Journal of medicinal chemistry 21739938 2011 Aug 11 https://www.ncbi.nlm.nih.gov/pubmed/21739938
Phosphine-catalyzed [4+2] annulations of 2-alkylallenoates and olefins: synthesis of multisubstituted cyclohexenes. Tran, Yang S; Martin, Tioga J; Kwon, Ohyun Chemistry, an Asian journal 21739609 2011 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/21739609
First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp. Wyche, Thomas P; Hou, Yanpeng; Braun, Doug; Cohen, Hannah C; Xiong, May P; Bugni, Tim S The Journal of organic chemistry 21736356 2011 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/21736356
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. J Biol Chem 21733839 2011 Sep 9 https://www.ncbi.nlm.nih.gov/pubmed/21733839
Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Prigozhina, Natalie L; Heisel, Andrew; Wei, Ke; Noberini, Roberta; Hunter, Edward A; Calzolari, Diego; Seldeen, Jordan R; Pasquale, Elena B; Ruiz-Lozano, Pilar; Mercola, Mark; Price, Jeffrey H Biology of the cell / under the auspices of the European Cell Biology Organization 21732911 2011 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/21732911
Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol. Asad, Naeem; Hanson, Paul R; Long, Toby R; Rayabarapu, Dinesh K; Rolfe, Alan Chemical communications (Cambridge, England) 21727956 2011 Sep 7 https://www.ncbi.nlm.nih.gov/pubmed/21727956
Receptor-based pharmacophore and pharmacophore key descriptors for virtual screening and QSAR modeling. Dong, Xialan; Ebalunode, Jerry O; Yang, Sheng-Yong; Zheng, Weifan Current computer-aided drug design 21726192 2011 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/21726192
Animal models of idiosyncratic drug-induced liver injury--current status. Roth, Robert A; Ganey, Patricia E Critical reviews in toxicology 21726137 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21726137
Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. Edlund, Anna; Loesgen, Sandra; Fenical, William; Jensen, Paul R Applied and environmental microbiology 21724881 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21724881
Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori. Fei, Y Y; Schmidt, A; Bylund, G; Johansson, D X; Henriksson, S; Lebrilla, C; Solnick, J V; Boren, T; Zhu, X D Analytical chemistry 21721569 2011 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/21721569
Synthesis and structure-activity evaluation of isatin-ýý-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein. Hall, Matthew D; Brimacombe, Kyle R; Varonka, Matthew S; Pluchino, Kristen M; Monda, Julie K; Li, Jiayang; Walsh, Martin J; Boxer, Matthew B; Warren, Timothy H; Fales, Henry M; Gottesman, Michael M Journal of medicinal chemistry 21721528 2011 Aug 25 https://www.ncbi.nlm.nih.gov/pubmed/21721528
Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling. Cho, Chul-Hee; Jung, Dai-Il; Neuenswander, Benjamin; Larock, Richard C ACS combinatorial science 21721520 2011 Sep 12 https://www.ncbi.nlm.nih.gov/pubmed/21721520
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples. Simons, Peter C; Young, Susan M; Carter, Mark B; Waller, Anna; Zhai, Dayong; Reed, John C; Edwards, Bruce S; Sklar, Larry A Nature protocols 21720309 2011 Jul https://www.ncbi.nlm.nih.gov/pubmed/21720309
Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Gonzalez, David J; Haste, Nina M; Hollands, Andrew; Fleming, Tinya C; Hamby, Matthew; Pogliano, Kit; Nizet, Victor; Dorrestein, Pieter C Microbiology (Reading, England) 21719540 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21719540
Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Antczak, Christophe; Shum, David; Bassit, Bhramdeo; Frattini, Mark G; Li, Yueming; de Stanchina, Elisa; Scheinberg, David A; Djaballah, Hakim Bioorganic & medicinal chemistry letters 21719286 2011 Aug 1 https://www.ncbi.nlm.nih.gov/pubmed/21719286
Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Walsh, Kevin B; Teijaro, John R; Wilker, Peter R; Jatzek, Anna; Fremgen, Daniel M; Das, Subash C; Watanabe, Tokiko; Hatta, Masato; Shinya, Kyoko; Suresh, Marulasiddappa; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B A Proceedings of the National Academy of Sciences of the United States of America 21715659 2011 Jul 19 https://www.ncbi.nlm.nih.gov/pubmed/21715659
QSAR analysis of the toxicity of nitroaromatics in Tetrahymena pyriformis: structural factors and possible modes of action. Artemenko, A G; Muratov, E N; Kuz'min, V E; Muratov, N N; Varlamova, E V; Kuz'mina, A V; Gorb, L G; Golius, A; Hill, F C; Leszczynski, J; Tropsha, A SAR and QSAR in environmental research 21714735 2011 Jul-Sep https://www.ncbi.nlm.nih.gov/pubmed/21714735
Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. Peterson, Katherine E; Cinelli, Maris A; Morrell, Andrew E; Mehta, Akhil; Dexheimer, Thomas S; Agama, Keli; Antony, Smitha; Pommier, Yves; Cushman, Mark Journal of medicinal chemistry 21710981 2011 Jul 28 https://www.ncbi.nlm.nih.gov/pubmed/21710981
A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae. Rasmussen, Lynn; White, E Lucile; Pathak, Ashish; Ayala, Julio C; Wang, Hongxia; Wu, Jian-He; Benitez, Jorge A; Silva, Anisia J Antimicrobial agents and chemotherapy 21709090 2011 Sep https://www.ncbi.nlm.nih.gov/pubmed/21709090
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Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. Wang, Hao-Ran; Wu, Meng; Yu, Haibo; Long, Shunyou; Stevens, Amy; Engers, Darren W; Sackin, Henry; Daniels, J Scott; Dawson, Eric S; Hopkins, Corey R; Lindsley, Craig W; Li, Min; McManus, Owen B ACS chemical biology 21615117 2011 Aug 19 https://www.ncbi.nlm.nih.gov/pubmed/21615117
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The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles. Conrad, Wayne E; Fukazawa, Ryo; Haddadin, Makhluf J; Kurth, Mark J Organic letters 21612219 2011 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/21612219
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Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Yang, Yu-Liang; Xu, Yuquan; Kersten, Roland D; Liu, Wei-Ting; Meehan, Michael J; Moore, Bradley S; Bandeira, Nuno; Dorrestein, Pieter C Angewandte Chemie (International ed. in English) 21574228 2011 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/21574228
Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Guerrero, Miguel; Urbano, Mariangela; Velaparthi, Subash; Zhao, Jian; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic & medicinal chemistry letters 21570287 2011 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/21570287
Synthesis, activity, and structural analysis of novel ýý-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Chung, Suhman; Himmel, Daniel M; Jiang, Jian-Kang; Wojtak, Krzysztof; Bauman, Joseph D; Rausch, Jason W; Wilson, Jennifer A; Beutler, John A; Thomas, Craig J; Arnold, Eddy; Le Grice, Stuart F J Journal of medicinal chemistry 21568335 2011 Jul 14 https://www.ncbi.nlm.nih.gov/pubmed/21568335
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High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry. Curpan, Ramona F; Simons, Peter C; Zhai, Dayong; Young, Susan M; Carter, Mark B; Bologa, Cristian G; Oprea, Tudor I; Satterthwait, Arnold C; Reed, John C; Edwards, Bruce S; Sklar, Larry A Assay and drug development technologies 21561376 2011 Oct https://www.ncbi.nlm.nih.gov/pubmed/21561376
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Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. Mevers, Emily; Liu, Wei-Ting; Engene, Niclas; Mohimani, Hosein; Byrum, Tara; Pevzner, Pavel A; Dorrestein, Pieter C; Spadafora, Carmenza; Gerwick, William H Journal of natural products 21488639 2011 May 27 https://www.ncbi.nlm.nih.gov/pubmed/21488639
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A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. Johnson, Ronald L; Hwang, Jong Yeon; Arnold, Leggy A; Huang, Ruili; Wichterman, Jennifer; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Guy, R Kiplin; Huang, Wenwei Journal of biomolecular screening 21482722 2011 Jul https://www.ncbi.nlm.nih.gov/pubmed/21482722
An improved cerulean fluorescent protein with enhanced brightness and reduced reversible photoswitching. Markwardt, Michele L; Kremers, Gert-Jan; Kraft, Catherine A; Ray, Krishanu; Cranfill, Paula J C; Wilson, Korey A; Day, Richard N; Wachter, Rebekka M; Davidson, Michael W; Rizzo, Mark A PloS one 21479270 2011 https://www.ncbi.nlm.nih.gov/pubmed/21479270
Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy. Gramling, S; Rogers, C; Liu, G; Reisman, D Oncogene 21478905 2011 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/21478905
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Zhang, Jun; Chalmers, Michael J; Stayrook, Keith R; Burris, Lorri L; Wang, Yongjun; Busby, Scott A; Pascal, Bruce D; Garcia-Ordonez, Ruben D; Bruning, John B; Istrate, Monica A; Kojetin, Douglas J; Dodge, Jeffrey A; Burris, Thomas P; Griffin, Patrick R Nature structural & molecular biology 21478866 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21478866
Acoustic responses of monodisperse lipid-encapsulated microbubble contrast agents produced by flow focusing. Kaya, Mehmet; Feingold, Steven; Hettiarachchi, Kanaka; Lee, Abraham P; Dayton, Paul A Bubble science engineering and technology 21475641 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/21475641
Microbial efflux pump inhibition: tactics and strategies. Tegos, George P; Haynes, Mark; Strouse, J Jacob; Khan, Mohiuddin Md T; Bologa, Cristian G; Oprea, Tudor I; Sklar, Larry A Current pharmaceutical design 21470111 2011 https://www.ncbi.nlm.nih.gov/pubmed/21470111
Importazole, a small molecule inhibitor of the transport receptor importin-ýý. Soderholm, Jonathan F; Bird, Stephen L; Kalab, Petr; Sampathkumar, Yasaswini; Hasegawa, Keisuke; Uehara-Bingen, Michael; Weis, Karsten; Heald, Rebecca ACS chemical biology 21469738 2011 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/21469738
A facile surfactant critical micelle concentration determination. Cai, Lifeng; Gochin, Miriam; Liu, Keliang Chemical communications (Cambridge, England) 21468398 2011 May 21 https://www.ncbi.nlm.nih.gov/pubmed/21468398
High Throughput Synthesis of 2,3,6-Trisubstituted-5,6-Dihydroimidazo[2,1-b]thiazole Derivatives. Li, Yangmei; Giulianotti, Marc; Houghten, Richard A Tetrahedron letters 21461055 2011 Feb 9 https://www.ncbi.nlm.nih.gov/pubmed/21461055
Three-component synthesis of cyclic enaminones via ketene cyclization. Seki, Hajime; Georg, Gunda I Organic letters 21456588 2011 May 6 https://www.ncbi.nlm.nih.gov/pubmed/21456588
Energy transfer cassettes in silica nanoparticles target intracellular organelles. Jose, Jiney; Loudet, Aurore; Ueno, Yuichiro; Wu, Liangxing; Chen, Hsiang-Yun; Son, Dong Hee; Barhoumi, Rola; Burghardt, Robert; Burgess, Kevin Organic & biomolecular chemistry 21455504 2011 May 21 https://www.ncbi.nlm.nih.gov/pubmed/21455504
Assay of the multiple energy-producing pathways of mammalian cells. Bochner, Barry R; Siri, Mark; Huang, Richard H; Noble, Shawn; Lei, Xiang-He; Clemons, Paul A; Wagner, Bridget K PloS one 21455318 2011 https://www.ncbi.nlm.nih.gov/pubmed/21455318
Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines. Pepe, Antonella; Pamment, Michael; Georg, Gunda I; Malhotra, Sanjay V The Journal of organic chemistry 21452823 2011 May 6 https://www.ncbi.nlm.nih.gov/pubmed/21452823
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Moura-Letts, Gustavo; Diblasi, Christine M; Bauer, Renato A; Tan, Derek S Proceedings of the National Academy of Sciences of the United States of America 21451137 2011 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/21451137
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Rosenthal, Andrew S; Tanega, Cordelle; Shen, Min; Mott, Bryan T; Bougie, James M; Nguyen, Dac-Trung; Misteli, Tom; Auld, Douglas S; Maloney, David J; Thomas, Craig J Bioorganic & medicinal chemistry letters 21450467 2011 May 15 https://www.ncbi.nlm.nih.gov/pubmed/21450467
Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. Salvador, Lilibeth A; Biggs, Jason S; Paul, Valerie J; Luesch, Hendrik Journal of natural products 21446699 2011 May 27 https://www.ncbi.nlm.nih.gov/pubmed/21446699
Actions of a picomolar short-acting S1Pýýý agonist in S1Pýýý-eGFP knock-in mice. Cahalan, Stuart M; Gonzalez-Cabrera, Pedro J; Sarkisyan, Gor; Nguyen, Nhan; Schaeffer, Marie-Therese; Huang, Liming; Yeager, Adam; Clemons, Bryan; Scott, Fiona; Rosen, Hugh Nature chemical biology 21445057 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21445057
Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Chu, Wenhua; Rothfuss, Justin; Zhou, Dong; Mach, Robert H Bioorganic & medicinal chemistry letters 21441025 2011 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/21441025
Highly substituted lactone/ester-containing furan library by the palladium-catalyzed carbonylation of hydroxyl-substituted 3-iodofurans. Cho, Chul-Hee; Larock, Richard C ACS combinatorial science 21434604 2011 May 9 https://www.ncbi.nlm.nih.gov/pubmed/21434604
Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria. Chlipala, George; Mo, Shunyan; Carcache de Blanco, Esperanza J; Ito, Aiko; Bazarek, Stanley; Orjala, Jimmy Pharmaceutical biology 21430788 2009 Jan https://www.ncbi.nlm.nih.gov/pubmed/21430788
The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Seyedsayamdost, Mohammad R; Case, Rebecca J; Kolter, Roberto; Clardy, Jon Nature chemistry 21430694 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21430694
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. Huang, Fei; Motlekar, Nuzhat A; Burgwin, Chelsea M; Napper, Andrew D; Diamond, Scott L; Mazin, Alexander V ACS chemical biology 21428443 2011 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/21428443
Chemistry and biology of macrolide antiparasitic agents. Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R; Boothroyd, John C; Khosla, Chaitan Journal of medicinal chemistry 21428405 2011 Apr 28 https://www.ncbi.nlm.nih.gov/pubmed/21428405
Functional model of metabolite gating by human voltage-dependent anion channel 2. Bauer, Andras J; Gieschler, Simone; Lemberg, Kathryn M; McDermott, Ann E; Stockwell, Brent R Biochemistry 21425834 2011 May 3 https://www.ncbi.nlm.nih.gov/pubmed/21425834
Hybrid top-down and bottom-up fabrication approach for wafer-scale plasmonic nanoplatforms. Dhawan, Anuj; Du, Yan; Batchelor, Dale; Wang, Hsin-Neng; Leonard, Donovon; Misra, Veena; Ozturk, Mehmet; Gerhold, Michael D; Vo-Dinh, Tuan Small (Weinheim an der Bergstrasse, Germany) 21425456 2011 Mar 21 https://www.ncbi.nlm.nih.gov/pubmed/21425456
Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines. Markina, Nataliya A; Mancuso, Raffaella; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C ACS combinatorial science 21410207 2011 May 9 https://www.ncbi.nlm.nih.gov/pubmed/21410207
Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Ledeboer, Nathan; Huang, Sheng-Xiong; Rajski, Scott R; Kron, Michael; Shen, Ben Organic letters 21405052 2011 Apr 15 https://www.ncbi.nlm.nih.gov/pubmed/21405052
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Bachovchin, Daniel A; Mohr, Justin T; Speers, Anna E; Wang, Chu; Berlin, Jacob M; Spicer, Timothy P; Fernandez-Vega, Virneliz; Chase, Peter; Hodder, Peter S; Schurer, Stephan C; Nomura, Daniel K; Rosen, Hugh; Fu, Gregory C; Cravatt, Benjamin F Proceedings of the National Academy of Sciences of the United States of America 21398589 2011 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/21398589
A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions. Du, Yuhong; Nikolovska-Coleska, Zaneta; Qui, Min; Li, Lian; Lewis, Iestyn; Dingledine, Raymond; Stuckey, Jeanne A; Krajewski, Krzysztof; Roller, Peter P; Wang, Shaomeng; Fu, Haian Assay and drug development technologies 21395401 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21395401
One-pot synthesis of 2-amino-indole-3-carboxamide and analogous. Wang, Kan; Herdtweck, Eberhardt; Domling, Alexander ACS combinatorial science 21395342 2011 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/21395342
Deep UV nano-microstructuring of substrates for surface plasmon resonance imaging. Dhawan, A; Duval, A; Nakkach, M; Barbillon, G; Moreau, J; Canva, M; Vo-Dinh, T Nanotechnology 21393822 2011 Apr 22 https://www.ncbi.nlm.nih.gov/pubmed/21393822
Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. LaFleur, Michael D; Lucumi, Edinson; Napper, Andrew D; Diamond, Scott L; Lewis, Kim The Journal of antimicrobial chemotherapy 21393183 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21393183
Protein cage nanoparticles bearing the LyP-1 peptide for enhanced imaging of macrophage-rich vascular lesions. Uchida, Masaki; Kosuge, Hisanori; Terashima, Masahiro; Willits, Deborah A; Liepold, Lars O; Young, Mark J; McConnell, Michael V; Douglas, Trevor ACS nano 21391720 2011 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/21391720
Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines. Chavez, Kathryn J; Feng, Xiaohong; Flanders, James A; Rodriguez, Eloy; Schroeder, Frank C Journal of natural products 21391655 2011 May 27 https://www.ncbi.nlm.nih.gov/pubmed/21391655
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Pan, Jen Q; Lewis, Michael C; Ketterman, Josh K; Clore, Elizabeth L; Riley, Misha; Richards, Keenan R; Berry-Scott, Erin; Liu, Xiulin; Wagner, Florence F; Holson, Edward B; Neve, Rachael L; Biechele, Travis L; Moon, Randall T; Scolnick, Edward M; Petryshe Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 21389981 2011 Jun https://www.ncbi.nlm.nih.gov/pubmed/21389981
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents. Evdokimov, Nikolai M; Van Slambrouck, Severine; Heffeter, Petra; Tu, Lee; Le Calve, Benjamin; Lamoral-Theys, Delphine; Hooten, Carla J; Uglinskii, Pavel Y; Rogelj, Snezna; Kiss, Robert; Steelant, Wim F A; Berger, Walter; Yang, Jeremy J; Bologa, Cristian G Journal of medicinal chemistry 21388138 2011 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/21388138
A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines. Qiao, Kangjian; Zhou, Hui; Xu, Wei; Zhang, Wenjun; Garg, Neil; Tang, Yi Organic letters 21384820 2011 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/21384820
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). Ghoreschi, Kamran; Jesson, Michael I; Li, Xiong; Lee, Jamie L; Ghosh, Sarbani; Alsup, Jason W; Warner, James D; Tanaka, Masao; Steward-Tharp, Scott M; Gadina, Massimo; Thomas, Craig J; Minnerly, John C; Storer, Chad E; LaBranche, Timothy P; Radi, Zaher A; Dowty, Martin E; Head, Richard D; Meyer, Debra M; Kishore, Nandini; O'Shea, John J Journal of immunology (Baltimore, Md. : 1950) 21383241 2011 Apr 1 https://www.ncbi.nlm.nih.gov/pubmed/21383241
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Chou, Tsui-Fen; Brown, Steve J; Minond, Dmitriy; Nordin, Brian E; Li, Kelin; Jones, Amanda C; Chase, Peter; Porubsky, Patrick R; Stoltz, Brian M; Schoenen, Frank J; Patricelli, Matthew P; Hodder, Peter; Rosen, Hugh; Deshaies, Raymond J Proceedings of the National Academy of Sciences of the United States of America 21383145 2011 Mar 22 https://www.ncbi.nlm.nih.gov/pubmed/21383145
Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity. Cruz, Daniel; Wang, Zhiming; Kibbie, Jon; Modlin, Robert; Kwon, Ohyun Proceedings of the National Academy of Sciences of the United States of America 21383121 2011 Apr 26 https://www.ncbi.nlm.nih.gov/pubmed/21383121
Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors. Busby, Scott A; Kumar, Naresh; Kuruvilla, Dana S; Istrate, Monica A; Conkright, Juliana J; Wang, Yongjun; Kamenecka, Theodore M; Cameron, Michael D; Roush, William R; Burris, Thomas P; Griffin, Patrick R ACS chemical biology 21381756 2011 Jun 17 https://www.ncbi.nlm.nih.gov/pubmed/21381756
Marinobufagenin levels in preeclamptic patients: a preliminary report. Agunanne, Enoch; Horvat, Darijana; Harrison, Recherael; Uddin, M Nasir; Jones, Richard; Kuehl, Thomas J; Ghanem, Daad Abi; Berghman, Luc R; Lai, Xinzhong; Li, Jing; Romo, Daniel; Puschett, Jules B American journal of perinatology 21380994 2011 Aug https://www.ncbi.nlm.nih.gov/pubmed/21380994
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Deng, Xianming; Dzamko, Nicolas; Prescott, Alan; Davies, Paul; Liu, Qingsong; Yang, Qingkai; Lee, Jiing-Dwan; Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Alessi, Dario R; Gray, Nathanael S Nature chemical biology 21378983 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21378983
The binding of fluorophores to proteins depends on the cellular environment. Kim, Yun Kyung; Lee, Jun-Seok; Bi, Xuezhi; Ha, Hyung-Ho; Ng, Shin Hui; Ahn, Young-hoon; Lee, Jae-Jung; Wagner, Bridget K; Clemons, Paul A; Chang, Young-Tae Angewandte Chemie (International ed. in English) 21370369 2011 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/21370369
Discovering small-molecule estrogen receptor ýý/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency. Sun, Aiming; Moore, Terry W; Gunther, Jillian R; Kim, Mi-Sun; Rhoden, Eric; Du, Yuhong; Fu, Haian; Snyder, James P; Katzenellenbogen, John A ChemMedChem 21365764 2011 Apr 4 https://www.ncbi.nlm.nih.gov/pubmed/21365764
The effect of inhaled gases on ultrasound contrast agent longevity in vivo. Itani, Malak; Mattrey, Robert F Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 21365328 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/21365328
Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon; Currie, Cameron R PloS one 21364940 2011 https://www.ncbi.nlm.nih.gov/pubmed/21364940
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Xia, Menghang; Shahane, Sampada A; Huang, Ruili; Titus, Steven A; Shum, Enoch; Zhao, Yong; Southall, Noel; Zheng, Wei; Witt, Kristine L; Tice, Raymond R; Austin, Christopher P Toxicology and applied pharmacology 21362439 2011 May 1 https://www.ncbi.nlm.nih.gov/pubmed/21362439
Equilibrium between a vinylogous ylide and a phosphonium dienolate zwitterion: vinylogous Wittig olefination versus vinylogous aldol-type reaction. Khong, San N; Tran, Yang S; Kwon, Ohyun Tetrahedron 21359169 2010 Jun https://www.ncbi.nlm.nih.gov/pubmed/21359169
Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production. Siddiquee, Khandaker; Hampton, Jessica; Khan, Susan; Zadory, Dan; Gleaves, Linda; Vaughan, Douglas E; Smith, Layton H Journal of hypertension 21358420 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21358420
RNA localization in bacteria. Keiler, Kenneth C Current opinion in microbiology 21354362 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21354362
Photoscattering effect in supercontinuum-generating photonic crystal fiber. Tu, H; Marks, D L; Jiang, Z; Boppart, S A Applied physics letters 21350681 2008 Feb 11 https://www.ncbi.nlm.nih.gov/pubmed/21350681
Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. Chou, Tsui-Fen; Deshaies, Raymond J The Journal of biological chemistry 21343295 2011 May 13 https://www.ncbi.nlm.nih.gov/pubmed/21343295
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields. Broccatelli, Fabio; Carosati, Emanuele; Neri, Annalisa; Frosini, Maria; Goracci, Laura; Oprea, Tudor I; Cruciani, Gabriele Journal of medicinal chemistry 21341745 2011 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/21341745
Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. Gunasekera, Sarath P; Owle, Chivas S; Montaser, Rana; Luesch, Hendrik; Paul, Valerie J Journal of natural products 21341718 2011 Apr 25 https://www.ncbi.nlm.nih.gov/pubmed/21341718
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Stanford, Stephanie M; Krishnamurthy, Divya; Falk, Matthew D; Messina, Rossella; Debnath, Bikash; Li, Sheng; Liu, Tong; Kazemi, Roza; Dahl, Russell; He, Yantao; Yu, Xiao; Chan, Andrew C; Zhang, Zhong-Yin; Barrios, Amy M; Woods Jr, Virgil L; Neamati, Nouri Journal of medicinal chemistry 21341673 2011 Mar 24 https://www.ncbi.nlm.nih.gov/pubmed/21341673
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Popowicz, Grzegorz M; Domling, Alexander; Holak, Tad A Angewandte Chemie (International ed. in English) 21341346 2011 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/21341346
Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluýýý. Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R ACS combinatorial science 21338051 2011 Mar 14 https://www.ncbi.nlm.nih.gov/pubmed/21338051
A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. Li, Hui-Fang; Keeton, Adam; Vitolo, Michele; Maddox, Clinton; Rasmussen, Lynn; Hobrath, Judith; White, E Lucille; Park, Ben Ho; Piazza, Gary A; Kim, Jung-Sik; Waldman, Todd Journal of biomolecular screening 21335596 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21335596
Biotin tethered homotryptamine derivatives: high affinity probes of the human serotonin transporter (hSERT). Tomlinson, Ian D; Iwamoto, Hideki; Blakely, Randy D; Rosenthal, Sandra J Bioorganic & medicinal chemistry letters 21334895 2011 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/21334895
Large-scale analysis of UPR-mediated apoptosis in human cells. Fribley, Andrew M; Miller, Justin R; Reist, Tyler E; Callaghan, Michael U; Kaufman, Randal J Methods in enzymology 21329794 2011 https://www.ncbi.nlm.nih.gov/pubmed/21329794
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Chalmers, Michael J; Busby, Scott A; Pascal, Bruce D; West, Graham M; Griffin, Patrick R Expert review of proteomics 21329427 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21329427
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. Liu, Qingsong; Wang, Jinhua; Kang, Seong A; Thoreen, Carson C; Hur, Wooyoung; Ahmed, Tausif; Sabatini, David M; Gray, Nathanael S Journal of medicinal chemistry 21322566 2011 Mar 10 https://www.ncbi.nlm.nih.gov/pubmed/21322566
The evolving field of imaging mass spectrometry and its impact on future biological research. Watrous, Jeramie D; Alexandrov, Theodore; Dorrestein, Pieter C Journal of mass spectrometry : JMS 21322093 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21322093
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. Hwang, Jong Yeon; Huang, Wenwei; Arnold, Leggy A; Huang, Ruili; Attia, Ramy R; Connelly, Michele; Wichterman, Jennifer; Zhu, Fangyi; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Johnson, Ronald L; Guy, R Kiplin The Journal of biological chemistry 21321127 2011 Apr 8 https://www.ncbi.nlm.nih.gov/pubmed/21321127
Vpr-host interactions during HIV-1 viral life cycle. Zhao, Richard Y; Li, Ge; Bukrinsky, Michael I Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 21318276 2011 Jun https://www.ncbi.nlm.nih.gov/pubmed/21318276
Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones. Fenster, Erik; Long, Toby R; Zang, Qin; Hill, David; Neuenswander, Benjamin; Lushington, Gerald H; Zhou, Aihua; Santini, Conrad; Hanson, Paul R ACS combinatorial science 21309582 2011 May 9 https://www.ncbi.nlm.nih.gov/pubmed/21309582
Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. Choi, Jayoung; Mouillesseaux, Kevin; Wang, Zhiming; Fiji, Hannah D G; Kinderman, Sape S; Otto, Georg W; Geisler, Robert; Kwon, Ohyun; Chen, Jau-Nian Development (Cambridge, England) 21307094 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21307094
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Gao, Xue; Chooi, Yit-Heng; Ames, Brian D; Wang, Peng; Walsh, Christopher T; Tang, Yi Journal of the American Chemical Society 21299212 2011 Mar 2 https://www.ncbi.nlm.nih.gov/pubmed/21299212
Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents. John, Renu; Nguyen, Freddy T; Kolbeck, Kenneth J; Chaney, Eric J; Marjanovic, Marina; Suslick, Kenneth S; Boppart, Stephen A Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 21298354 2012 Feb https://www.ncbi.nlm.nih.gov/pubmed/21298354
Development of an HTS-compatible assay for discovery of RORýý modulators using AlphaScreenýý technology. Istrate, Monica A; Spicer, Timothy P; Wang, Yan; Bernard, Jerrold A; Helvering, Leah M; Bocchinfuso, Wayne P; Richardson, Timothy I; Zink, Richard; Kumar, Naresh; Montrose-Rafizadeh, Chahrzad; Dodge, Jeffrey; Hodder, Peter; Griffin, Patrick R Journal of biomolecular screening 21297105 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21297105
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents. Yuan, Peixiong; Tragon, Tyson; Xia, Menghang; Leclair, Christopher A; Skoumbourdis, Amanda P; Zheng, Wei; Thomas, Craig J; Huang, Ruili; Austin, Christopher P; Chen, Guang; Guitart, Xavier Pharmacology, biochemistry, and behavior 21296104 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21296104
Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries. Lopez-Vallejo, Fabian; Nefzi, Adel; Bender, Andreas; Owen, John R; Nabney, Ian T; Houghten, Richard A; Medina-Franco, Jose L Chemical biology & drug design 21294850 2011 May https://www.ncbi.nlm.nih.gov/pubmed/21294850
Facile syntheses of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]-pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles. Avila, Belem; Solano, Danielle M; Haddadin, Makhluf J; Kurth, Mark J Organic letters 21294577 2011 Mar 4 https://www.ncbi.nlm.nih.gov/pubmed/21294577
Chiral kinase inhibitors. Jiang, Jian-kang; Shen, Min; Thomas, Craig J; Boxer, Mathew B Current topics in medicinal chemistry 21291394 2011 https://www.ncbi.nlm.nih.gov/pubmed/21291394
CEST MRI reporter genes. Liu, Guanshu; Bulte, Jeff W M; Gilad, Assaf A Methods in molecular biology (Clifton, N.J.) 21279607 2011 https://www.ncbi.nlm.nih.gov/pubmed/21279607
Amide proton transfer imaging of the human brain. Zhou, Jinyuan Methods in molecular biology (Clifton, N.J.) 21279604 2011 https://www.ncbi.nlm.nih.gov/pubmed/21279604
Off-resonance saturation MRI of superparamagnetic nanoprobes: theoretical models and experimental validations. Khemtong, Chalermchai; Togao, Osamu; Ren, Jimin; Kessinger, Chase W; Takahashi, Masaya; Sherry, A Dean; Gao, Jinming Journal of magnetic resonance (San Diego, Calif. : 1997) 21277813 2011 Mar https://www.ncbi.nlm.nih.gov/pubmed/21277813
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Titanium-catalyzed stereoselective synthesis of spirooxindole oxazolines. Badillo, Joseph J; Arevalo, Gary E; Fettinger, James C; Franz, Annaliese K Organic letters 21186788 2011 Feb 4 https://www.ncbi.nlm.nih.gov/pubmed/21186788
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CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice. Wang, Qiang; Hillwig, Matthew L; Peters, Reuben J The Plant journal : for cell and molecular biology 21175892 2011 Jan https://www.ncbi.nlm.nih.gov/pubmed/21175892
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Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-a-go-go related gene potassium channels. Zou, Beiyan; Yu, Haibo; Babcock, Joseph J; Chanda, Pritam; Bader, Joel S; McManus, Owen B; Li, Min Assay and drug development technologies 21158688 2010 Dec https://www.ncbi.nlm.nih.gov/pubmed/21158688
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High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Chen, Catherine Z; Kulakova, Liudmila; Southall, Noel; Marugan, Juan J; Galkin, Andrey; Austin, Christopher P; Herzberg, Osnat; Zheng, Wei Antimicrobial agents and chemotherapy 21078930 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21078930
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High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. Niesen, Frank H; Schultz, Lena; Jadhav, Ajit; Bhatia, Chitra; Guo, Kunde; Maloney, David J; Pilka, Ewa S; Wang, Minghua; Oppermann, Udo; Heightman, Tom D; Simeonov, Anton PloS one 21072165 2010 https://www.ncbi.nlm.nih.gov/pubmed/21072165
NMR-spectroscopic analysis of mixtures: from structure to function. Forseth, Ry R; Schroeder, Frank C Current opinion in chemical biology 21071261 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21071261
Practical 4'-phosphopantetheine active site discovery from proteomic samples. Meier, Jordan L; Patel, Anand D; Niessen, Sherry; Meehan, Michael; Kersten, Roland; Yang, Jane Y; Rothmann, Michael; Cravatt, Benjamin F; Dorrestein, Pieter C; Burkart, Michael D; Bafna, Vineet Journal of proteome research 21067235 2011 Jan 7 https://www.ncbi.nlm.nih.gov/pubmed/21067235
Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines. Haddadin, Makhluf J; Bou Zerdan, Raghida M; Kurth, Mark J; Fettinger, James C Organic letters 21067220 2010 Dec 3 https://www.ncbi.nlm.nih.gov/pubmed/21067220
Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Dorjsuren, Dorjbal; Kim, Daemyung; Maloney, David J; Wilson 3rd, David M; Simeonov, Anton Nucleic acids research 21062821 2011 Jan https://www.ncbi.nlm.nih.gov/pubmed/21062821
Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen. Maddry, Joseph A; Chen, Xi; Jonsson, Colleen B; Ananthan, Subramaniam; Hobrath, Judith; Smee, Donald F; Noah, James W; Noah, Diana; Xu, Xiaolin; Jia, Fuli; Maddox, Clinton; Sosa, Melinda I; White, E Lucile; Severson, William E Journal of biomolecular screening 21059874 2011 Jan https://www.ncbi.nlm.nih.gov/pubmed/21059874
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Metabolomics of urine for the assessment of microvesicular lipid accumulation in the liver following isoniazid exposure. Sumner, Susan J; Burgess, Jason P; Snyder, Rodney W; Popp, James A; Fennell, Timothy R Metabolomics : Official journal of the Metabolomic Society 21057652 2010 Jun 1 https://www.ncbi.nlm.nih.gov/pubmed/21057652
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Atomic-level characterization of the ensemble of the Aýý(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms. Sgourakis, Nikolaos G; Merced-Serrano, Myrna; Boutsidis, Christos; Drineas, Petros; Du, Zheming; Wang, Chunyu; Garcia, Angel E Journal of molecular biology 21056574 2011 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/21056574
Emergent properties of proteostasis-COPII coupled systems in human health and disease. Routledge, Katy E; Gupta, Vijay; Balch, William E Molecular membrane biology 21054154 2010 Nov https://www.ncbi.nlm.nih.gov/pubmed/21054154
Identification and characterization of steroidogenic factor-1 inverse agonists. Doghman, Mabrouka; Madoux, Franck; Hodder, Peter; Lalli, Enzo Methods in enzymology 21050908 2010 https://www.ncbi.nlm.nih.gov/pubmed/21050908
Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling. Ashley, Jason W; McCoy, Erin M; Clements, Daniel A; Shi, Zhenqi; Chen, Taosheng; Feng, Xu Assay and drug development technologies 21050071 2011 Feb https://www.ncbi.nlm.nih.gov/pubmed/21050071
A high-throughput screening strategy to overcome virus instability. Rasmussen, Lynn; Maddox, Clinton; Moore, Blake P; Severson, William; White, E Lucile Assay and drug development technologies 21050067 2011 Apr https://www.ncbi.nlm.nih.gov/pubmed/21050067
Identification of novel small molecule activators of nuclear factor-ýýB with neuroprotective action via high-throughput screening. Manuvakhova, Marina S; Johnson, Guyla G; White, Misti C; Ananthan, Subramaniam; Sosa, Melinda; Maddox, Clinton; McKellip, Sara; Rasmussen, Lynn; Wennerberg, Krister; Hobrath, Judith V; White, E Lucile; Maddry, Joseph A; Grimaldi, Maurizio Journal of neuroscience research 21046675 2011 Jan https://www.ncbi.nlm.nih.gov/pubmed/21046675
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. Kojetin, Douglas; Wang, Yongjun; Kamenecka, Theodore M; Burris, Thomas P ACS chemical biology 21043485 2011 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/21043485
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Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. Emert-Sedlak, Lori; Kodama, Toshiaki; Lerner, Edwina C; Dai, Weixiang; Foster, Caleb; Day, Billy W; Lazo, John S; Smithgall, Thomas E ACS chemical biology 19807124 2009 Nov 20 https://www.ncbi.nlm.nih.gov/pubmed/19807124
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Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Sidique, Shyama; Ardecky, Robert; Su, Ying; Narisawa, Sonoko; Brown, Brock; Millan, Jose Luis; Sergienko, Eduard; Cosford, Nicholas D P Bioorganic & medicinal chemistry letters 19038545 2009 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/19038545
Advancing microarray assembly with acoustic dispensing technology. Wong, E Y; Diamond, S L Analytical chemistry 19035650 2009 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/19035650
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Human Rad54 protein stimulates human Mus81-Eme1 endonuclease. Mazina, Olga M; Mazin, Alexander V Proceedings of the National Academy of Sciences of the United States of America 19017809 2008 Nov 25 https://www.ncbi.nlm.nih.gov/pubmed/19017809
Discovery and development of heat shock protein 90 inhibitors. Taldone, Tony; Sun, Weilin; Chiosis, Gabriela Bioorganic & medicinal chemistry 19017562 2009 Mar 15 https://www.ncbi.nlm.nih.gov/pubmed/19017562
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The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Sahin, Selma; Benet, Leslie Z Pharmaceutical research 19015955 2008 Dec https://www.ncbi.nlm.nih.gov/pubmed/19015955
A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand. Strouse, J Jacob; Young, Susan M; Mitchell, Hugh D; Ye, Richard D; Prossnitz, Eric R; Sklar, Larry A; Edwards, Bruce S Cytometry. Part A : the journal of the International Society for Analytical Cytology 19006074 2009 Mar https://www.ncbi.nlm.nih.gov/pubmed/19006074
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Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions. Sun, Y S; Landry, J P; Fei, Y Y; Zhu, X D; Luo, J T; Wang, X B; Lam, K S Langmuir : the ACS journal of surfaces and colloids 18991423 2008 Dec 2 https://www.ncbi.nlm.nih.gov/pubmed/18991423
Modeling of nonlinear viscous stress in encapsulating shells of lipid-coated contrast agent microbubbles. Doinikov, Alexander A; Haac, Jillian F; Dayton, Paul A Ultrasonics 18990417 2009 Feb https://www.ncbi.nlm.nih.gov/pubmed/18990417
Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. Gonzalez-Cestari, Tatiana F; Henderson, Brandon J; Pavlovicz, Ryan E; McKay, Susan B; El-Hajj, Raed A; Pulipaka, Aravinda B; Orac, Crina M; Reed, Damon D; Boyd, R Thomas; Zhu, Michael X; Li, Chenglong; Bergmeier, Stephen C; McKay, Dennis B The Journal of pharmacology and experimental therapeutics 18984653 2009 Feb https://www.ncbi.nlm.nih.gov/pubmed/18984653
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Optical response of linear chains of metal nanospheres and nanospheroids. Norton, Stephen J; Vo-Dinh, Tuan Journal of the Optical Society of America. A, Optics, image science, and vision 18978855 2008 Nov https://www.ncbi.nlm.nih.gov/pubmed/18978855
Surface-grafting of phosphates onto a polymer for potential biomimetic functionalization of biomaterials. Ko, Young Gun; Ma, Peter X Journal of colloid and interface science 18977490 2009 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/18977490
Resonance frequencies of lipid-shelled microbubbles in the regime of nonlinear oscillations. Doinikov, Alexander A; Haac, Jillian F; Dayton, Paul A Ultrasonics 18977009 2009 Feb https://www.ncbi.nlm.nih.gov/pubmed/18977009
A human ferritin iron oxide nano-composite magnetic resonance contrast agent. Uchida, Masaki; Terashima, Masahiro; Cunningham, Charles H; Suzuki, Yoriyasu; Willits, Deborah A; Willis, Ann F; Yang, Philip C; Tsao, Philip S; McConnell, Michael V; Young, Mark J; Douglas, Trevor Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 18956458 2008 Nov https://www.ncbi.nlm.nih.gov/pubmed/18956458
Isolation and structure determination of a proteasome inhibitory metabolite from a culture of Scytonema hofmanni. Shim, Sang Hee; Chlipala, George; Orjala, Jimmy Journal of microbiology and biotechnology 18955814 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18955814
Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes. Torreira, Eva; Jha, Sudhakar; Lopez-Blanco, Jose R; Arias-Palomo, Ernesto; Chacon, Pablo; Canas, Cristina; Ayora, Sylvia; Dutta, Anindya; Llorca, Oscar Structure (London, England : 1993) 18940606 2008 Oct 8 https://www.ncbi.nlm.nih.gov/pubmed/18940606
Parallel synthesis of a multi-substituted benzo[b]furan library. Cho, Chul-Hee; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C Journal of combinatorial chemistry 18937516 2008 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/18937516
Surface-enhanced Raman nanoparticle beacons based on bioconjugated gold nanocrystals and long range plasmonic coupling. Qian, Ximei; Zhou, Xi; Nie, Shuming Journal of the American Chemical Society 18937463 2008 Nov 12 https://www.ncbi.nlm.nih.gov/pubmed/18937463
Remarkably efficient synthesis of 2H-indazole 1-oxides and 2H-indazoles via tandem carbon-carbon followed by nitrogen-nitrogen bond formation. Bouillon, Isabelle; Zajicek, Jaroslav; Pudelova, Nadyyzda; Krchnak, Viktor The Journal of organic chemistry 18937414 2008 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/18937414
A new synthesis of symmetric boraindacene (BODIPY) dyes. Wu, Liangxing; Burgess, Kevin Chemical communications (Cambridge, England) 18931743 2008 Oct 28 https://www.ncbi.nlm.nih.gov/pubmed/18931743
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Shaw, Patrick J; Ditewig, Amy C; Waring, Jeffrey F; Liguori, Michael J; Blomme, Eric A; Ganey, Patricia E; Roth, Robert A Toxicological sciences : an official journal of the Society of Toxicology 18930950 2009 Jan https://www.ncbi.nlm.nih.gov/pubmed/18930950
Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7). Iscru, Emilia; Serinagaoglu, Yelda; Schilling, Karl; Tian, Jinbin; Bowers-Kidder, Stephanie L; Zhang, Rui; Morgan, James I; DeVries, A Courtney; Nelson, Randy J; Zhu, Michael X; Oberdick, John Molecular and cellular neurosciences 18930827 2009 Jan https://www.ncbi.nlm.nih.gov/pubmed/18930827
Synthesis and spectroscopic properties of rosamines with cyclic amine substituents. Wu, Liangxing; Burgess, Kevin The Journal of organic chemistry 18928318 2008 Nov 21 https://www.ncbi.nlm.nih.gov/pubmed/18928318
Advances in MR spectroscopy of the prostate. Kurhanewicz, John; Vigneron, Daniel B Magnetic resonance imaging clinics of North America 18926432 2008 Nov https://www.ncbi.nlm.nih.gov/pubmed/18926432
Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. Kiyosawa, Naoki; Kwekel, Joshua C; Burgoon, Lyle D; Dere, Edward; Williams, Kurt J; Tashiro, Colleen; Chittim, Brock; Zacharewski, Timothy R BMC genomics 18925944 2008 https://www.ncbi.nlm.nih.gov/pubmed/18925944
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Albers, Mark J; Bok, Robert; Chen, Albert P; Cunningham, Charles H; Zierhut, Matt L; Zhang, Vickie Yi; Kohler, Susan J; Tropp, James; Hurd, Ralph E; Yen, Yi-Fen; Nelson, Sarah J; Vigneron, Daniel B; Kurhanewicz, John Cancer research 18922937 2008 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/18922937
Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening. Bakan, Ahmet; Lazo, John S; Wipf, Peter; Brummond, Kay M; Bahar, Ivet Current medicinal chemistry 18855677 2008 https://www.ncbi.nlm.nih.gov/pubmed/18855677
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Patel, Vishal; Booker, Michael; Kramer, Martin; Ross, Leila; Celatka, Cassandra A; Kennedy, Leah M; Dvorin, Jeffrey D; Duraisingh, Manoj T; Sliz, Piotr; Wirth, Dyann F; Clardy, Jon The Journal of biological chemistry 18842591 2008 Dec 12 https://www.ncbi.nlm.nih.gov/pubmed/18842591
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Coller, Barry S; Shattil, Sanford J Blood 18840725 2008 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/18840725
Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites. Lin, Yiqing; Schiavo, Susan; Orjala, Jimmy; Vouros, Paul; Kautz, Roger Analytical chemistry 18834150 2008 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/18834150
BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis. Seo, Seong Il; Gera, Lajos; Zhau, Haiyen E; Qian, Wei Ping; Iqbal, Shareen; Johnson, Nicole A; Zhang, Shumin; Zayzafoon, Majd; Stewart, John; Wang, Ruoxiang; Chung, Leland W K; Wu, Daqing Clinical cancer research : an official journal of the American Association for Cancer Research 18829499 2008 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/18829499
Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. Sharlow, Elizabeth R; Giridhar, Karthik V; LaValle, Courtney R; Chen, Jun; Leimgruber, Stephanie; Barrett, Rebecca; Bravo-Altamirano, Karla; Wipf, Peter; Lazo, John S; Wang, Q Jane The Journal of biological chemistry 18829454 2008 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/18829454
2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro. Jennings, Benjamin C; Nadolski, Marissa J; Ling, Yiping; Baker, Meredith Beckham; Harrison, Marietta L; Deschenes, Robert J; Linder, Maurine E Journal of lipid research 18827284 2009 Feb https://www.ncbi.nlm.nih.gov/pubmed/18827284
pKa prediction of monoprotic small molecules the SMARTS way. Lee, Adam C; Yu, Jing-Yu; Crippen, Gordon M Journal of chemical information and modeling 18826209 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18826209
Differences between high- and low-affinity complexes of enzymes and nonenzymes. Carlson, Heather A; Smith, Richard D; Khazanov, Nickolay A; Kirchhoff, Paul D; Dunbar Jr, James B; Benson, Mark L Journal of medicinal chemistry 18826206 2008 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/18826206
Plastinated tissue samples as three-dimensional models for optical instrument characterization. Marks, Daniel L; Chaney, Eric J; Boppart, Stephen A Optics express 18825267 2008 Sep 29 https://www.ncbi.nlm.nih.gov/pubmed/18825267
Visualization of long human telomere mimics by single-molecule fluorescence imaging. Pomerantz, Andrea K; Moerner, W E; Kool, Eric T The journal of physical chemistry. B 18817431 2008 Oct 23 https://www.ncbi.nlm.nih.gov/pubmed/18817431
New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI. McMahon, Michael T; Gilad, Assaf A; DeLiso, Marco A; Berman, Stacey M Cromer; Bulte, Jeff W M; van Zijl, Peter C M Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 18816830 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18816830
B,O-chelated azadipyrromethenes as near-IR probes. Loudet, Aurore; Bandichhor, Rakeshwar; Burgess, Kevin; Palma, Aniello; McDonnell, Shane O; Hall, Michael J; O'Shea, Donal F Organic letters 18816131 2008 Nov 6 https://www.ncbi.nlm.nih.gov/pubmed/18816131
Combinatorial libraries of bis-heterocyclic compounds with skeletal diversity. Soural, Miroslav; Bouillon, Isabelle; Krchnak, Viktor Journal of combinatorial chemistry 18811208 2008 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/18811208
Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses. Dudgeon, Drew D; Zhang, Nannan; Ositelu, Olufisayo O; Kim, Hyemin; Cunningham, Kyle W Eukaryotic cell 18806210 2008 Dec https://www.ncbi.nlm.nih.gov/pubmed/18806210
Gap junction coupling and calcium waves in the pancreatic islet. Benninger, Richard K P; Zhang, Min; Head, W Steven; Satin, Leslie S; Piston, David W Biophysical journal 18805925 2008 Dec https://www.ncbi.nlm.nih.gov/pubmed/18805925
A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole. Bowman, Grant R; Comolli, Luis R; Zhu, Jian; Eckart, Michael; Koenig, Marcelle; Downing, Kenneth H; Moerner, W E; Earnest, Thomas; Shapiro, Lucy Cell 18805088 2008 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/18805088
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury. Deng, Xiaomin; Liguori, Michael J; Sparkenbaugh, Erica M; Waring, Jeffrey F; Blomme, Eric A G; Ganey, Patricia E; Roth, Robert A The Journal of pharmacology and experimental therapeutics 18801949 2008 Dec https://www.ncbi.nlm.nih.gov/pubmed/18801949
A comparative analysis of standard microtiter plate reading versus imaging in cellular assays. Bushway, Paul J; Mercola, Mark; Price, Jeffrey H Assay and drug development technologies 18795873 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18795873
Super-resolution imaging in live Caulobacter crescentus cells using photoswitchable EYFP. Biteen, Julie S; Thompson, Michael A; Tselentis, Nicole K; Bowman, Grant R; Shapiro, Lucy; Moerner, W E Nature methods 18794860 2008 Nov https://www.ncbi.nlm.nih.gov/pubmed/18794860
NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species. Schroeder, Frank C; Taggi, Andrew E; Gronquist, Matthew; Malik, Rabia U; Grant, Jacqualine B; Eisner, Thomas; Meinwald, Jerrold Proceedings of the National Academy of Sciences of the United States of America 18794518 2008 Sep 23 https://www.ncbi.nlm.nih.gov/pubmed/18794518
Modeling of the acoustic response from contrast agent microbubbles near a rigid wall. Doinikov, Alexander A; Zhao, Shukui; Dayton, Paul A Ultrasonics 18789469 2009 Feb https://www.ncbi.nlm.nih.gov/pubmed/18789469
Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs. Lewis, Jana A; Daniels, R Nathan; Lindsley, Craig W Organic letters 18788742 2008 Oct 16 https://www.ncbi.nlm.nih.gov/pubmed/18788742
Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. Yu, Gui Jun; Yoo, Choong L; Yang, Baoxue; Lodewyk, Michael W; Meng, Liping; El-Idreesy, Tamer T; Fettinger, James C; Tantillo, Dean J; Verkman, A S; Kurth, Mark J Journal of medicinal chemistry 18788728 2008 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/18788728
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Young, Susan M; Bologa, Cristian M; Fara, Dan; Bryant, Bj K; Strouse, Juan Jacob; Arterburn, Jeffrey B; Ye, Richard D; Oprea, Tudor I; Prossnitz, Eric R; Sklar, Larry A; Edwards, Bruce S Cytometry. Part A : the journal of the International Society for Analytical Cytology 18785269 2009 Mar https://www.ncbi.nlm.nih.gov/pubmed/18785269
One-pot synthesis, encapsulation, and solubilization of size-tuned quantum dots with amphiphilic multidentate ligands. Kairdolf, Brad A; Smith, Andrew M; Nie, Shuming Journal of the American Chemical Society 18774812 2008 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/18774812
Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Adams, Stephen R; Tsien, Roger Y Nature protocols 18772880 2008 https://www.ncbi.nlm.nih.gov/pubmed/18772880
Live cell surface labeling with fluorescent Ag nanocluster conjugates. Yu, Junhua; Choi, Sungmoon; Richards, Chris I; Antoku, Yasuko; Dickson, Robert M Photochemistry and photobiology 18764887 2008 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/18764887
Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay. Ganesh, Thota; Thepchatri, Pahk; Li, Lian; Du, Yuhong; Fu, Haian; Snyder, James P; Sun, Aiming Bioorganic & medicinal chemistry letters 18762423 2008 Sep 15 https://www.ncbi.nlm.nih.gov/pubmed/18762423
Compounds that confer thermal stress resistance and extended lifespan. Benedetti, Michael G; Foster, Amanda L; Vantipalli, Maithili C; White, Mark P; Sampayo, James N; Gill, Matthew S; Olsen, Anders; Lithgow, Gordon J Experimental gerontology 18755260 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18755260
Cy3-Cy5 covalent heterodimers for single-molecule photoswitching. Conley, Nicholas R; Biteen, Julie S; Moerner, W E The journal of physical chemistry. B 18754575 2008 Sep 25 https://www.ncbi.nlm.nih.gov/pubmed/18754575
Critical assessment of QSAR models of environmental toxicity against Tetrahymena pyriformis: focusing on applicability domain and overfitting by variable selection. Tetko, Igor V; Sushko, Iurii; Pandey, Anil Kumar; Zhu, Hao; Tropsha, Alexander; Papa, Ester; Oberg, Tomas; Todeschini, Roberto; Fourches, Denis; Varnek, Alexandre Journal of chemical information and modeling 18729318 2008 Sep https://www.ncbi.nlm.nih.gov/pubmed/18729318
Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Tessem, May-Britt; Swanson, Mark G; Keshari, Kayvan R; Albers, Mark J; Joun, David; Tabatabai, Z Laura; Simko, Jeffry P; Shinohara, Katsuto; Nelson, Sarah J; Vigneron, Daniel B; Gribbestad, Ingrid S; Kurhanewicz, John Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 18727052 2008 Sep https://www.ncbi.nlm.nih.gov/pubmed/18727052
Targeting QseC signaling and virulence for antibiotic development. Rasko, David A; Moreira, Cristiano G; Li, De Run; Reading, Nicola C; Ritchie, Jennifer M; Waldor, Matthew K; Williams, Noelle; Taussig, Ron; Wei, Shuguang; Roth, Michael; Hughes, David T; Huntley, Jason F; Fina, Maggy W; Falck, John R; Sperandio, Vanessa Science (New York, N.Y.) 18719281 2008 Aug 22 https://www.ncbi.nlm.nih.gov/pubmed/18719281
Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries. Sharlow, Elizabeth R; Leimgruber, Stephanie; Yellow-Duke, Archibong; Barrett, Rebecca; Wang, Qiming Jane; Lazo, John S Nature protocols 18714303 2008 https://www.ncbi.nlm.nih.gov/pubmed/18714303
Palladium-catalyzed one-step synthesis of isoindole-1,3-diones by carbonylative cyclization of o-halobenzoates and primary amines. Worlikar, Shilpa A; Larock, Richard C The Journal of organic chemistry 18712929 2008 Sep 19 https://www.ncbi.nlm.nih.gov/pubmed/18712929
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High throughput synthesis of peptide alpha-thioesters through the use of "volatilizable" support. Li, Yangmei; Yu, Yongping; Giulianotti, Marc; Houghten, Richard A Journal of combinatorial chemistry 18710293 2008 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/18710293
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Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. Johnston, Paul A; Soares, Karina M; Shinde, Sunita N; Foster, Caleb A; Shun, Tong Ying; Takyi, Harold K; Wipf, Peter; Lazo, John S Assay and drug development technologies 18699726 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18699726
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Minimizing the hydrodynamic size of quantum dots with multifunctional multidentate polymer ligands. Smith, Andrew M; Nie, Shuming Journal of the American Chemical Society 18680294 2008 Aug 27 https://www.ncbi.nlm.nih.gov/pubmed/18680294
An engineered aryl azide ligase for site-specific mapping of protein-protein interactions through photo-cross-linking. Baruah, Hemanta; Puthenveetil, Sujiet; Choi, Yoon-Aa; Shah, Samit; Ting, Alice Y Angewandte Chemie (International ed. in English) 18677791 2008 https://www.ncbi.nlm.nih.gov/pubmed/18677791
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Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase. Hur, Wooyoung; Velentza, Anastasia; Kim, Sungjoon; Flatauer, Laura; Jiang, Xinnong; Valente, David; Mason, Daniel E; Suzuki, Melissa; Larson, Brad; Zhang, Jianming; Zagorska, Anna; Didonato, Michael; Nagle, Advait; Warmuth, Markus; Balk, Steven P; Peters, Bioorganic & medicinal chemistry letters 18667312 2008 Nov 15 https://www.ncbi.nlm.nih.gov/pubmed/18667312
Probing the compatibility of type II ketosynthase-carrier protein partners. Worthington, Andrew S; Hur, Gene H; Meier, Jordan L; Cheng, Qian; Moore, Bradley S; Burkart, Michael D Chembiochem : a European journal of chemical biology 18666307 2008 Sep 1 https://www.ncbi.nlm.nih.gov/pubmed/18666307
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A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Lea, Wendy A; Jadhav, Ajit; Rai, Ganesha; Sayed, Ahmed A; Cass, Cynthia L; Inglese, James; Williams, David L; Austin, Christopher P; Simeonov, Anton Assay and drug development technologies 18665782 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18665782
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Niswender, Colleen M; Johnson, Kari A; Weaver, C David; Jones, Carrie K; Xiang, Zixiu; Luo, Qingwei; Rodriguez, Alice L; Marlo, Joy E; de Paulis, Tomas; Thompson, Analisa D; Days, Emily L; Nalywajko, Tasha; Austin, Cheryl A; Williams, Michael Baxter; Ayal Molecular pharmacology 18664603 2008 Nov https://www.ncbi.nlm.nih.gov/pubmed/18664603
Resin capsules: permeable containers for parallel/combinatorial solid-phase organic synthesis. Bouillon, Isabelle; Soural, Miroslav; Krchnak, Viktor Journal of combinatorial chemistry 18656988 2008 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/18656988
Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo. Mancini, Michael C; Kairdolf, Brad A; Smith, Andrew M; Nie, Shuming Journal of the American Chemical Society 18652463 2008 Aug 20 https://www.ncbi.nlm.nih.gov/pubmed/18652463
Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut. Borlee, Bradley R; Geske, Grant D; Robinson, Courtney J; Blackwell, Helen E; Handelsman, Jo The ISME journal 18650927 2008 Nov https://www.ncbi.nlm.nih.gov/pubmed/18650927
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Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues. Oldenburg, Amy L; Crecea, Vasilica; Rinne, Stephanie A; Boppart, Stephen A Optics express 18648474 2008 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/18648474
Optical micro-scale mapping of dynamic biomechanical tissue properties. Liang, Xing; Oldenburg, Amy L; Crecea, Vasilica; Chaney, Eric J; Boppart, Stephen A Optics express 18648419 2008 Jul 21 https://www.ncbi.nlm.nih.gov/pubmed/18648419
Brevisamide: an unprecedented monocyclic ether alkaloid from the dinoflagellate Karenia brevis that provides a potential model for ladder-frame initiation. Satake, Masayuki; Bourdelais, Andrea J; Van Wagoner, Ryan M; Baden, Daniel G; Wright, Jeffrey L C Organic letters 18646771 2008 Aug 21 https://www.ncbi.nlm.nih.gov/pubmed/18646771
Targeting Hsp90: small-molecule inhibitors and their clinical development. Taldone, Tony; Gozman, Alexander; Maharaj, Ronnie; Chiosis, Gabriela Current opinion in pharmacology 18644253 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18644253
Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases. Schwartz, Samantha L; Tessema, Mathewos; Buranda, Tione; Pylypenko, Olena; Rak, Alexey; Simons, Peter C; Surviladze, Zurab; Sklar, Larry A; Wandinger-Ness, Angela Analytical biochemistry 18638444 2008 Oct 15 https://www.ncbi.nlm.nih.gov/pubmed/18638444
Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). Banerjee, Sangeeta R; Foss, Catherine A; Castanares, Mark; Mease, Ronnie C; Byun, Youngjoo; Fox, James J; Hilton, John; Lupold, Shawn E; Kozikowski, Alan P; Pomper, Martin G Journal of medicinal chemistry 18637669 2008 Aug 14 https://www.ncbi.nlm.nih.gov/pubmed/18637669
Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae. Qin, Hong; Lu, Meng; Goldfarb, David S PloS one 18628831 2008 https://www.ncbi.nlm.nih.gov/pubmed/18628831
High-throughput screening-based identification of paramyxovirus inhibitors. Yoon, Jeong-Joong; Chawla, Dhruv; Paal, Tanja; Ndungu, Maina; Du, Yuhong; Kurtkaya, Serdar; Sun, Aiming; Snyder, James P; Plemper, Richard K Journal of biomolecular screening 18626114 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18626114
Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions. Carpenter, Richard D; Fettinger, James C; Lam, Kit S; Kurth, Mark J Angewandte Chemie (International ed. in English) 18624312 2008 https://www.ncbi.nlm.nih.gov/pubmed/18624312
Rad51 protein stimulates the branch migration activity of Rad54 protein. Rossi, Matthew J; Mazin, Alexander V The Journal of biological chemistry 18617519 2008 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/18617519
Induction of osteoblast differentiation phenotype on poly(L-lactic acid) nanofibrous matrix. Hu, Jiang; Liu, Xiaohua; Ma, Peter X Biomaterials 18617260 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18617260
Enzyme microarrays assembled by acoustic dispensing technology. Wong, E Y; Diamond, S L Analytical biochemistry 18616925 2008 Oct 1 https://www.ncbi.nlm.nih.gov/pubmed/18616925
Preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. Agarkov, Anton; Gilbertson, Scott R Journal of combinatorial chemistry 18611055 2008 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/18611055
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Scaffold topologies. 1. Exhaustive enumeration up to eight rings. Pollock, Sara N; Coutsias, Evangelos A; Wester, Michael J; Oprea, Tudor I Journal of chemical information and modeling 18605680 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18605680
Molecular docking of cathepsin L inhibitors in the binding site of papain. Beavers, Mary Pat; Myers, Michael C; Shah, Parag P; Purvis, Jeremy E; Diamond, Scott L; Cooperman, Barry S; Huryn, Donna M; Smith 3rd, Amos B Journal of chemical information and modeling 18598021 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18598021
Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Motlekar, Nuzhat; Diamond, Scott L; Napper, Andrew D Assay and drug development technologies 18593377 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18593377
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening. Schurer, Stephan C; Brown, Steven J; Gonzalez-Cabrera, Pedro J; Schaeffer, Marie-Therese; Chapman, Jacqueline; Jo, Euijung; Chase, Peter; Spicer, Tim; Hodder, Peter; Rosen, Hugh ACS chemical biology 18590333 2008 Aug 15 https://www.ncbi.nlm.nih.gov/pubmed/18590333
Data mining the NCI60 to predict generalized cytotoxicity. Lee, Adam C; Shedden, Kerby; Rosania, Gustavo R; Crippen, Gordon M Journal of chemical information and modeling 18588283 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18588283
Improved synthesis of DCDHF fluorophores with maleimide functional groups. Lu, Zhikuan; Weber, Ryan; Twieg, Robert J Tetrahedron letters 18584068 2006 Oct 2 https://www.ncbi.nlm.nih.gov/pubmed/18584068
MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles. Gilad, Assaf A; Walczak, Piotr; McMahon, Michael T; Na, Hyon Bin; Lee, Jung Hee; An, Kwangjin; Hyeon, Taegwhan; van Zijl, Peter C M; Bulte, Jeff W M Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 18581402 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18581402
Plasmodium falciparum: development of a transgenic line for screening antimalarials using firefly luciferase as the reporter. Cui, Long; Miao, Jun; Wang, Jiaxu; Li, Qianjun; Cui, Liwang Experimental parasitology 18579134 2008 Sep https://www.ncbi.nlm.nih.gov/pubmed/18579134
Single-molecule motions of oligoarginine transporter conjugates on the plasma membrane of Chinese hamster ovary cells. Lee, H-L; Dubikovskaya, E A; Hwang, H; Semyonov, A N; Wang, H; Jones, L R; Twieg, R J; Moerner, W E; Wender, P A Journal of the American Chemical Society 18578528 2008 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/18578528
Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Marsolais, David; Hahm, Bumsuk; Edelmann, Kurt H; Walsh, Kevin B; Guerrero, Miguel; Hatta, Yasuko; Kawaoka, Yoshihiro; Roberts, Edward; Oldstone, Michael B A; Rosen, Hugh Molecular pharmacology 18577684 2008 Sep https://www.ncbi.nlm.nih.gov/pubmed/18577684
A photoactivatable push-pull fluorophore for single-molecule imaging in live cells. Lord, Samuel J; Conley, Nicholas R; Lee, Hsiao-lu D; Samuel, Reichel; Liu, Na; Twieg, Robert J; Moerner, W E Journal of the American Chemical Society 18572940 2008 Jul 23 https://www.ncbi.nlm.nih.gov/pubmed/18572940
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. Ganesh, Thota; Min, Jaeki; Thepchatri, Pahk; Du, Yuhong; Li, Lian; Lewis, Iestyn; Wilson, Larry; Fu, Haian; Chiosis, Gabriela; Dingledine, Raymond; Liotta, Dennis; Snyder, James P; Sun, Aiming Bioorganic & medicinal chemistry 18571929 2008 Jul 15 https://www.ncbi.nlm.nih.gov/pubmed/18571929
Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. Flavell, Robert R; Kothari, Paresh; Bar-Dagan, Maya; Synan, Michael; Vallabhajosula, Shankar; Friedman, Jeffrey M; Muir, Tom W; Ceccarini, Giovanni Journal of the American Chemical Society 18570424 2008 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/18570424
Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. Yezhelyev, Maksym V; Qi, Lifeng; O'Regan, Ruth M; Nie, Shuming; Gao, Xiaohu Journal of the American Chemical Society 18570415 2008 Jul 16 https://www.ncbi.nlm.nih.gov/pubmed/18570415
Protein reactions with surface-bound molecular targets detected by oblique-incidence reflectivity difference microscopes. Landry, J P; Sun, Y S; Guo, X W; Zhu, X D Applied optics 18566623 2008 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/18566623
Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chiang, Yi-Ming; Szewczyk, Edyta; Nayak, Tania; Davidson, Ashley D; Sanchez, James F; Lo, Hsien-Chun; Ho, Wen-Yueh; Simityan, Hagop; Kuo, Eric; Praseuth, Alex; Watanabe, Kenji; Oakley, Berl R; Wang, Clay C C Chemistry & biology 18559263 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18559263
Golgi governance: the third way. Simon, Sanford M Cell 18555771 2008 Jun 13 https://www.ncbi.nlm.nih.gov/pubmed/18555771
Synthesis of sultam scaffolds via intramolecular oxa-Michael and diastereoselective Baylis-Hillman reactions. Zhou, Aihua; Hanson, Paul R Organic letters 18553974 2008 Jul 17 https://www.ncbi.nlm.nih.gov/pubmed/18553974
QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Zhang, Liying; Zhu, Hao; Oprea, Tudor I; Golbraikh, Alexander; Tropsha, Alexander Pharmaceutical research 18553217 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18553217
Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. Xie, Xinmin; Wisor, Jonathan P; Hara, Junko; Crowder, Tara L; LeWinter, Robin; Khroyan, Taline V; Yamanaka, Akihiro; Diano, Sabrina; Horvath, Tamas L; Sakurai, Takeshi; Toll, Lawrence; Kilduff, Thomas S The Journal of clinical investigation 18551194 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18551194
Dynamics of dynamin during clathrin mediated endocytosis in PC12 cells. Rappoport, Joshua Z; Heyman, Katherine P; Kemal, Shahrnaz; Simon, Sanford M PloS one 18545672 2008 https://www.ncbi.nlm.nih.gov/pubmed/18545672
High-throughput nuclear magnetic resonance metabolomic footprinting for tissue engineering. Seagle, Christopher; Christie, Megan A; Winnike, Jason H; McClelland, Randall E; Ludlow, John W; O'Connell, Thomas M; Gamcsik, Michael P; MacDonald, Jeffrey M Tissue engineering. Part C, Methods 18544027 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18544027
Advances in structurally characterized lanthanide alkoxide, aryloxide, and silyloxide compounds. Boyle, Timothy J; Ottley, Leigh Anna M Chemical reviews 18543875 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18543875
Anomalous bending effect in photonic crystal fibers. Tu, Haohua; Jiang, Zhi; Marks, Daniel L; Boppart, Stephen A Optics express 18542666 2008 Apr 14 https://www.ncbi.nlm.nih.gov/pubmed/18542666
Real-time interferometric synthetic aperture microscopy. Ralston, Tyler S; Marks, Daniel L; Carney, P Scott; Boppart, Stephen A Optics express 18542337 2008 Feb 18 https://www.ncbi.nlm.nih.gov/pubmed/18542337
A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Kimple, Adam J; Yasgar, Adam; Hughes, Mark; Jadhav, Ajit; Willard, Francis S; Muller, Robin E; Austin, Christopher P; Inglese, James; Ibeanu, Gordon C; Siderovski, David P; Simeonov, Anton Combinatorial chemistry & high throughput screening 18537560 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18537560
Fluorescence techniques using dehydroergosterol to study cholesterol trafficking. McIntosh, Avery L; Atshaves, Barbara P; Huang, Huan; Gallegos, Adalberto M; Kier, Ann B; Schroeder, Friedhelm Lipids 18536950 2008 Dec https://www.ncbi.nlm.nih.gov/pubmed/18536950
Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion. Chigaev, Alexandre; Waller, Anna; Amit, Or; Sklar, Larry A BMC immunology 18534032 2008 https://www.ncbi.nlm.nih.gov/pubmed/18534032
Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex. Sun, Aiming; Yoon, Jeong-Joong; Yin, Yan; Prussia, Andrew; Yang, Yutao; Min, Jaeki; Plemper, Richard K; Snyder, James P Journal of medicinal chemistry 18529043 2008 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/18529043
Controlling the reactivity of ampiphilic quantum dots in biological assays through hydrophobic assembly of custom PEG derivatives. Warnement, Michael R; Tomlinson, Ian D; Chang, Jerry C; Schreuder, Michael A; Luckabaugh, Courtney M; Rosenthal, Sandra J Bioconjugate chemistry 18529022 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18529022
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Barak, Larry S; Salahpour, Ali; Zhang, Xiaodong; Masri, Bernard; Sotnikova, Tatyana D; Ramsey, Amy J; Violin, Jonathan D; Lefkowitz, Robert J; Caron, Marc G; Gainetdinov, Raul R Molecular pharmacology 18524885 2008 Sep https://www.ncbi.nlm.nih.gov/pubmed/18524885
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Desbordes, Sabrina C; Placantonakis, Dimitris G; Ciro, Anthony; Socci, Nicholas D; Lee, Gabsang; Djaballah, Hakim; Studer, Lorenz Cell stem cell 18522853 2008 Jun 5 https://www.ncbi.nlm.nih.gov/pubmed/18522853
Characterization of osteopontin expression and function after status epilepticus. Borges, Karin; Gearing, Marla; Rittling, Susan; Sorensen, Esben S; Kotloski, Robert; Denhardt, David T; Dingledine, Raymond Epilepsia 18522644 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18522644
poolHiTS: a shifted transversal design based pooling strategy for high-throughput drug screening. Kainkaryam, Raghunandan M; Woolf, Peter J BMC bioinformatics 18513431 2008 https://www.ncbi.nlm.nih.gov/pubmed/18513431
Phosphoprotein profiling by PA-GeLC-MS/MS. Kristjansdottir, Kolbrun; Wolfgeher, Donald; Lucius, Nick; Angulo, David Sigfredo; Kron, Stephen J Journal of proteome research 18510356 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18510356
Molecular recognition based on low-affinity polyvalent interactions: selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells. McRae, Reagan L; Phillips, Ronnie L; Kim, Ik-Bum; Bunz, Uwe H F; Fahrni, Christoph J Journal of the American Chemical Society 18507462 2008 Jun 25 https://www.ncbi.nlm.nih.gov/pubmed/18507462
Membrane-interaction quantitative structure--activity relationship (MI-QSAR) analyses of skin penetration enhancers. Zheng, Tao; Hopfinger, A J; Esposito, Emilio X; Liu, Jianzhong; Tseng, Yufeng J Journal of chemical information and modeling 18507373 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18507373
Synthesis of 5-(thiazol-5-yl)-4,5-dihydroisoxazoles from 3-chloropentane-2,4-dione. Milinkevich, Kristin A; Ye, Long; Kurth, Mark J Journal of combinatorial chemistry 18505299 2008 Jul-Aug https://www.ncbi.nlm.nih.gov/pubmed/18505299
Quantitative modeling of selective lysosomal targeting for drug design. Trapp, Stefan; Rosania, Gus R; Horobin, Richard W; Kornhuber, Johannes European biophysics journal : EBJ 18504571 2008 Oct https://www.ncbi.nlm.nih.gov/pubmed/18504571
Imaging the biogenesis of individual HIV-1 virions in live cells. Jouvenet, Nolwenn; Bieniasz, Paul D; Simon, Sanford M Nature 18500329 2008 Jul 10 https://www.ncbi.nlm.nih.gov/pubmed/18500329
Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Myers, Michael C; Shah, Parag P; Beavers, Mary Pat; Napper, Andrew D; Diamond, Scott L; Smith 3rd, Amos B; Huryn, Donna M Bioorganic & medicinal chemistry letters 18499453 2008 Jun 15 https://www.ncbi.nlm.nih.gov/pubmed/18499453
A functional GFP fusion for imaging clathrin-mediated endocytosis. Rappoport, Joshua Z; Simon, Sanford M Traffic (Copenhagen, Denmark) 18498437 2008 Aug https://www.ncbi.nlm.nih.gov/pubmed/18498437
Bioconjugated quantum dots for in vivo molecular and cellular imaging. Smith, Andrew M; Duan, Hongwei; Mohs, Aaron M; Nie, Shuming Advanced drug delivery reviews 18495291 2008 Aug 17 https://www.ncbi.nlm.nih.gov/pubmed/18495291
The unusual macrocycle forming thioesterase of mycolactone. Meier, Jordan L; Barrows-Yano, Tiffany; Foley, Timothy L; Wike, Candice L; Burkart, Michael D Molecular bioSystems 18493665 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18493665
Evolution of natural product scaffolds by acyl- and arylnitroso hetero-diels-alder reactions: new chemistry on piperine. Krchnak, Viktor; Waring, Katherine R; Noll, Bruce C; Moellmann, Ute; Dahse, Hans-Martin; Miller, Marvin J The Journal of organic chemistry 18489157 2008 Jun 20 https://www.ncbi.nlm.nih.gov/pubmed/18489157
N-[N-[(S)-1,3-Dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine, [18F]DCFBC: a new imaging probe for prostate cancer. Mease, Ronnie C; Dusich, Crystal L; Foss, Catherine A; Ravert, Hayden T; Dannals, Robert F; Seidel, Jurgen; Prideaux, Andrew; Fox, James J; Sgouros, George; Kozikowski, Alan P; Pomper, Martin G Clinical cancer research : an official journal of the American Association for Cancer Research 18483369 2008 May 15 https://www.ncbi.nlm.nih.gov/pubmed/18483369
Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers. Nayak, Tapan K; Hathaway, Helen J; Ramesh, Chinnasamy; Arterburn, Jeffrey B; Dai, Donghai; Sklar, Larry A; Norenberg, Jeffrey P; Prossnitz, Eric R Journal of nuclear medicine : official publication, Society of Nuclear Medicine 18483091 2008 Jun https://www.ncbi.nlm.nih.gov/pubmed/18483091
A chemical approach to stem-cell biology and regenerative medicine. Xu, Yue; Shi, Yan; Ding, Sheng Nature 18480815 2008 May 15 https://www.ncbi.nlm.nih.gov/pubmed/18480815
Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. Chen, Albert P; Kurhanewicz, John; Bok, Robert; Xu, Duan; Joun, David; Zhang, Vickie; Nelson, Sarah J; Hurd, Ralph E; Vigneron, Daniel B Magnetic resonance imaging 18479878 2008 Jul https://www.ncbi.nlm.nih.gov/pubmed/18479878
Benzyne click chemistry: synthesis of benzotriazoles from benzynes and azides. Shi, Feng; Waldo, Jesse P; Chen, Yu; Larock, Richard C Organic letters 18476707 2008 Jun 19 https://www.ncbi.nlm.nih.gov/pubmed/18476707
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Dai, Susie Y; Chalmers, Michael J; Bruning, John; Bramlett, Kelli S; Osborne, Harold E; Montrose-Rafizadeh, Chahrzad; Barr, Robert J; Wang, Yong; Wang, Minmin; Burris, Thomas P; Dodge, Jeffrey A; Griffin, Patrick R Proceedings of the National Academy of Sciences of the United States of America 18474858 2008 May 20 https://www.ncbi.nlm.nih.gov/pubmed/18474858
Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging. Leevy, W Matthew; Lambert, Timothy N; Johnson, James R; Morris, Joshua; Smith, Bradley D Chemical communications (Cambridge, England) 18473060 2008 May 28 https://www.ncbi.nlm.nih.gov/pubmed/18473060
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Zinc ferrite nanoparticles as MRI contrast agents. Barcena, Carlos; Sra, Amandeep K; Chaubey, Girija S; Khemtong, Chalermchai; Liu, J Ping; Gao, Jinming Chemical communications (Cambridge, England) 18463747 2008 May 21 https://www.ncbi.nlm.nih.gov/pubmed/18463747
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Dysregulation of glutamate carboxypeptidase II in psychiatric disease. Guilarte, Tomas R; Hammoud, Dima A; McGlothan, Jennifer L; Caffo, Brian S; Foss, Catherine A; Kozikowski, Alan P; Pomper, Martin G Schizophrenia research 18191545 2008 Feb https://www.ncbi.nlm.nih.gov/pubmed/18191545
Identification of possible sources of nanotoxicity from carbon nanotubes inserted into membrane bilayers using membrane interaction quantitative structure--activity relationship analysis. Liu, Jianzhong; Hopfinger, Anton J Chemical research in toxicology 18189365 2008 Feb https://www.ncbi.nlm.nih.gov/pubmed/18189365
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. Johnston, Paul A; Phillips, Jennifer; Shun, Tong Ying; Shinde, Sunita; Lazo, John S; Huryn, Donna M; Myers, Michael C; Ratnikov, Boris I; Smith, Jeffrey W; Su, Ying; Dahl, Russell; Cosford, Nicholas D P; Shiryaev, Sergey A; Strongin, Alex Y Assay and drug development technologies 18181690 2007 Dec https://www.ncbi.nlm.nih.gov/pubmed/18181690
Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1. Sharlow, Elizabeth R; Leimgruber, Stephanie; Shun, Tong Ying; Lazo, John S Assay and drug development technologies 18181689 2007 Dec https://www.ncbi.nlm.nih.gov/pubmed/18181689
Lipid diffusion from single molecules of a labeled protein undergoing dynamic association with giant unilamellar vesicles and supported bilayers. Sharonov, Alexey; Bandichhor, Rakeshwar; Burgess, Kevin; Petrescu, Anca D; Schroeder, Friedhelm; Kier, Ann B; Hochstrasser, Robin M Langmuir : the ACS journal of surfaces and colloids 18181653 2008 Feb 5 https://www.ncbi.nlm.nih.gov/pubmed/18181653
Global transformation of OBOC combinatorial peptide libraries into OBOC polyamine and small molecule libraries. Kappel, Joseph C; Fan, Yi C; Lam, Kit S Journal of combinatorial chemistry 18181577 2008 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/18181577
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. Xiao, Rui; Tang, Jisen; Wang, Chunbo; Colton, Craig K; Tian, Jinbin; Zhu, Michael X The Journal of biological chemistry 18178557 2008 Mar 7 https://www.ncbi.nlm.nih.gov/pubmed/18178557
Structural and functional characterization of a new recombinant histidine-tagged acyl coenzyme A binding protein (ACBP) from mouse. Petrescu, Anca D; Huang, Huan; Hostetler, Heather A; Schroeder, Friedhelm; Kier, Ann B Protein expression and purification 18178100 2008 Apr https://www.ncbi.nlm.nih.gov/pubmed/18178100
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Lewis, L Michelle; Sheffler, Douglas; Williams, Richard; Bridges, Thomas M; Kennedy, J Phillip; Brogan, J T; Mulder, Matthew J; Williams, Lyndsey; Nalywajko, Natalia T; Niswender, Colleen M; Weaver, Charles D; Conn, P Jeffrey; Lindsley, Craig W Bioorganic & medicinal chemistry letters 18178088 2008 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/18178088
Compact biocompatible quantum dots functionalized for cellular imaging. Liu, Wenhao; Howarth, Mark; Greytak, Andrew B; Zheng, Yi; Nocera, Daniel G; Ting, Alice Y; Bawendi, Moungi G Journal of the American Chemical Society 18177042 2008 Jan 30 https://www.ncbi.nlm.nih.gov/pubmed/18177042
A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Niswender, Colleen M; Johnson, Kari A; Luo, Qingwei; Ayala, Jennifer E; Kim, Caroline; Conn, P Jeffrey; Weaver, C David Molecular pharmacology 18171729 2008 Apr https://www.ncbi.nlm.nih.gov/pubmed/18171729
Ionic immobilization, diversification, and release: application to the generation of a library of methionine aminopeptidase inhibitors. Vedantham, Punitha; Guerra, Jennifer M; Schoenen, Frank; Huang, Min; Gor, Parul J; Georg, Gunda I; Wang, Jenna L; Neuenswander, Benjamin; Lushington, Gerald H; Mitscher, Lester A; Ye, Qi-Zhuang; Hanson, Paul R Journal of combinatorial chemistry 18163595 2008 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/18163595
Studies towards the synthesis of methionine aminopeptidase inhibitors: diversification utilizing a ROMP-derived coupling reagent. Vedantham, Punitha; Zhang, Mianji; Gor, Parul J; Huang, Min; Georg, Gunda I; Lushington, Gerald H; Mitscher, Lester A; Ye, Qi-Zhuang; Hanson, Paul R Journal of combinatorial chemistry 18163594 2008 Mar-Apr https://www.ncbi.nlm.nih.gov/pubmed/18163594
FRET by fluorescence polarization microscopy. Piston, David W; Rizzo, Mark A Methods in cell biology 18155473 2008 https://www.ncbi.nlm.nih.gov/pubmed/18155473
Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. Poleshko, Andrey; Palagin, Ivan; Zhang, Rugang; Boimel, Pamela; Castagna, Carolyn; Adams, Peter D; Skalka, Anna Marie; Katz, Richard A Journal of virology 18094192 2008 Mar https://www.ncbi.nlm.nih.gov/pubmed/18094192
A combinatorial method for solution-phase synthesis of labeled bivalent beta-turn mimics. Angell, Yu; Chen, Dianjun; Brahimi, Fouad; Saragovi, H Uri; Burgess, Kevin Journal of the American Chemical Society 18088119 2008 Jan 16 https://www.ncbi.nlm.nih.gov/pubmed/18088119
High-throughput screen for small molecule inhibitors of Mint1-PDZ domains. Chen, Xuesong; Longgood, Jamie C; Michnoff, Carolyn; Wei, Shuguang; Frantz, Doug E; Bezprozvanny, Llya Assay and drug development technologies 18078379 2007 Dec https://www.ncbi.nlm.nih.gov/pubmed/18078379
Solid-supported nitroso hetero Diels-Alder reactions. 1. Acylnitroso dienophiles: scope and limitations. Krchnak, Viktor; Moellmann, Ute; Dahse, Hans-Martin; Miller, Marvin J Journal of combinatorial chemistry 18067271 2008 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/18067271
Solid-supported nitroso hetero-Diels-Alder reactions. 3. Acid-mediated transformation of cycloadducts by scission of the oxazine C-O bonds. Krchnak, Viktor; Moellmann, Ute; Dahse, Hans-Martin; Miller, Marvin J Journal of combinatorial chemistry 18067270 2008 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/18067270
Glycan antagonists and inhibitors: a fount for drug discovery. Brown, Jillian R; Crawford, Brett E; Esko, Jeffrey D Critical reviews in biochemistry and molecular biology 18066955 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/18066955
Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry. Parker, Laurie; Engel-Hall, Aaron; Drew, Kevin; Steinhardt, George; Helseth Jr, Donald L; Jabon, David; McMurry, Timothy; Angulo, David S; Kron, Stephen J Journal of mass spectrometry : JMS 18064576 2008 Apr https://www.ncbi.nlm.nih.gov/pubmed/18064576
Solid-supported nitroso hetero diels-alder reactions. 2. Arylnitroso dienophiles: scope and limitations. Krchnak, Viktor; Moellmann, Ute; Dahse, Hans-Martin; Miller, Marvin J Journal of combinatorial chemistry 18062671 2008 Jan-Feb https://www.ncbi.nlm.nih.gov/pubmed/18062671
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Myers, Michael C; Shah, Parag P; Diamond, Scott L; Huryn, Donna M; Smith 3rd, Amos B Bioorganic & medicinal chemistry letters 18060772 2008 Jan 1 https://www.ncbi.nlm.nih.gov/pubmed/18060772
Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators. Song, Yumei; Buelow, Ben; Perraud, Anne-Laure; Scharenberg, Andrew M Journal of biomolecular screening 18057180 2008 Jan https://www.ncbi.nlm.nih.gov/pubmed/18057180
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Tran, T Cameron; Sneed, Blossom; Haider, Jamil; Blavo, Delali; White, Audrey; Aiyejorun, Temitope; Baranowski, Timothy C; Rubinstein, Amy L; Doan, Thanh N; Dingledine, Raymond; Sandberg, Eric M Cancer research 18056466 2007 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/18056466
Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging. Talu, Esra; Hettiarachchi, Kanaka; Zhao, Shukui; Powell, Robert L; Lee, Abraham P; Longo, Marjorie L; Dayton, Paul A Molecular imaging 18053409 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/18053409
A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations. Butler, Jeffrey D; Solano, Danielle M; Robins, Lori I; Haddadin, Makhluf J; Kurth, Mark J The Journal of organic chemistry 18052193 2008 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/18052193
Asymmetric Mannich reaction of dicarbonyl compounds with alpha-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones. Lou, Sha; Dai, Peng; Schaus, Scott E The Journal of organic chemistry 18047372 2007 Dec 21 https://www.ncbi.nlm.nih.gov/pubmed/18047372
Biomimetic materials for tissue engineering. Ma, Peter X Advanced drug delivery reviews 18045729 2008 Jan 14 https://www.ncbi.nlm.nih.gov/pubmed/18045729
Functionalization of the 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) core. Li, Lingling; Nguyen, Binh; Burgess, Kevin Bioorganic & medicinal chemistry letters 18037291 2008 May 15 https://www.ncbi.nlm.nih.gov/pubmed/18037291
Evaluation of the effect of ethanol's toxic metabolite acetaldehyde on the gastrointestinal oligopeptide transporter, PEPT1: in vitro and in vivo studies. Fisher, Scott J; Lee, Insong J; Swaan, Peter W; Eddington, Natalie D Alcoholism, clinical and experimental research 18028524 2008 Jan https://www.ncbi.nlm.nih.gov/pubmed/18028524
Mechanistic insight into the diastereoselective rhodium-catalyzed Pauson-Khand reaction: role of coordination number in stereocontrol. Wang, Huijun; Sawyer, James R; Evans, P Andrew; Baik, Mu-Hyun Angewandte Chemie (International ed. in English) 18022985 2008 https://www.ncbi.nlm.nih.gov/pubmed/18022985
Extending microarray quality control and analysis algorithms to Illumina chip platform. Stokes, Todd H; Han, Xiao; Moffitt, Richard A; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 18003039 2007 https://www.ncbi.nlm.nih.gov/pubmed/18003039
Improved bolstering error estimation for gene ranking. Huynh, Kiet N T; Phan, John H; Vo, Tan M; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 18003038 2007 https://www.ncbi.nlm.nih.gov/pubmed/18003038
Reproducibility of differential gene detection across multiple microarray studies. Vo, Tan M; Phan, John H; Huynh, Kiet N T; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 18002936 2007 https://www.ncbi.nlm.nih.gov/pubmed/18002936
Exploration of quantitative scoring metrics to compare systems biology modeling approaches. Kaddi, Chanchala; Oden, Erica D; Quo, Chang F; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 18002159 2007 https://www.ncbi.nlm.nih.gov/pubmed/18002159
Modified genetic algorithm for parameter selection of compartmental models. Shah, Neil A; Moffitt, Richard A; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 18001909 2007 https://www.ncbi.nlm.nih.gov/pubmed/18001909
Optical coherence tomography: a review of clinical development from bench to bedside. Zysk, Adam M; Nguyen, Freddy T; Oldenburg, Amy L; Marks, Daniel L; Boppart, Stephen A Journal of biomedical optics 17994864 2007 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/17994864
o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Kiyosawa, Naoki; Kwekel, Joshua C; Burgoon, Lyle D; Williams, Kurt J; Tashiro, Colleen; Chittim, Brock; Zacharewski, Timothy R Toxicological sciences : an official journal of the Society of Toxicology 17984292 2008 Feb https://www.ncbi.nlm.nih.gov/pubmed/17984292
Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. Ruan, Gang; Agrawal, Amit; Marcus, Adam I; Nie, Shuming Journal of the American Chemical Society 17983227 2007 Nov 28 https://www.ncbi.nlm.nih.gov/pubmed/17983227
The synthesis of highly substituted isoxazoles by electrophilic cyclization: an efficient synthesis of valdecoxib. Waldo, Jesse P; Larock, Richard C The Journal of organic chemistry 17979295 2007 Dec 7 https://www.ncbi.nlm.nih.gov/pubmed/17979295
A novel functional translocator protein ligand for cancer imaging. Bai, Mingfeng; Rone, Malena B; Papadopoulos, Vassilios; Bornhop, Darryl J Bioconjugate chemistry 17979225 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/17979225
Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles. Meng, Liping; Fettinger, James C; Kurth, Mark J Organic letters 17973485 2007 Nov 22 https://www.ncbi.nlm.nih.gov/pubmed/17973485
Viral capsids as MRI contrast agents. Liepold, Lars; Anderson, Stasia; Willits, Deborah; Oltrogge, Luke; Frank, Joseph A; Douglas, Trevor; Young, Mark Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 17969126 2007 Nov https://www.ncbi.nlm.nih.gov/pubmed/17969126
Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Chen, Albert P; Albers, Mark J; Cunningham, Charles H; Kohler, Susan J; Yen, Yi-Fen; Hurd, Ralph E; Tropp, James; Bok, Robert; Pauly, John M; Nelson, Sarah J; Kurhanewicz, John; Vigneron, Daniel B Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 17969006 2007 Dec https://www.ncbi.nlm.nih.gov/pubmed/17969006
RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection. Derre, Isabelle; Pypaert, Marc; Dautry-Varsat, Alice; Agaisse, Herve PLoS pathogens 17967059 2007 Oct 26 https://www.ncbi.nlm.nih.gov/pubmed/17967059
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. McColl, Gawain; Killilea, David W; Hubbard, Alan E; Vantipalli, Maithili C; Melov, Simon; Lithgow, Gordon J The Journal of biological chemistry 17959600 2008 Jan 4 https://www.ncbi.nlm.nih.gov/pubmed/17959600
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. Lauer-Fields, Janelle L; Spicer, Timothy P; Chase, Peter S; Cudic, Mare; Burstein, Gayle D; Nagase, Hideaki; Hodder, Peter; Fields, Gregg B Analytical biochemistry 17949675 2008 Feb 1 https://www.ncbi.nlm.nih.gov/pubmed/17949675
ChemBank: a small-molecule screening and cheminformatics resource database. Seiler, Kathleen Petri; George, Gregory A; Happ, Mary Pat; Bodycombe, Nicole E; Carrinski, Hyman A; Norton, Stephanie; Brudz, Steve; Sullivan, John P; Muhlich, Jeremy; Serrano, Martin; Ferraiolo, Paul; Tolliday, Nicola J; Schreiber, Stuart L; Clemons, Pau Nucleic acids research 17947324 2008 Jan https://www.ncbi.nlm.nih.gov/pubmed/17947324
Automatic microtubule tracking for QD-based in vivo cell imaging and drug efficacy study. Kong, Koon Yin; Marcus, Adam I; Hong, Jin Young; Giannakakou, Paraskevi; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 17947021 2006 https://www.ncbi.nlm.nih.gov/pubmed/17947021
Detecting and quantifying biomarkers of risk for colorectal cancer using quantum dots and novel image analysis algorithms. Bostick, Roberd M; Kong, Koon Yin; Ahearn, Thomas U; Chaudry, Qaiser; Cohen, Vaunita; Wang, May D Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 17947019 2006 https://www.ncbi.nlm.nih.gov/pubmed/17947019
Advances in contrast enhancement for optical coherence tomography. Boppart, Stephen A Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 17946382 2006 https://www.ncbi.nlm.nih.gov/pubmed/17946382
Small-molecule inhibitors of the Rce1p CaaX protease. Manandhar, Surya P; Hildebrandt, Emily R; Schmidt, Walter K Journal of biomolecular screening 17942791 2007 Oct https://www.ncbi.nlm.nih.gov/pubmed/17942791
High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. Du, Yuhong; Moulick, Kamalika; Rodina, Anna; Aguirre, Julia; Felts, Sara; Dingledine, Raymond; Fu, Haian; Chiosis, Gabriela Journal of biomolecular screening 17942784 2007 Oct https://www.ncbi.nlm.nih.gov/pubmed/17942784
Chemical data mining of the NCI human tumor cell line database. Wang, Huijun; Klinginsmith, Jonathan; Dong, Xiao; Lee, Adam C; Guha, Rajarshi; Wu, Yuqing; Crippen, Gordon M; Wild, David J Journal of chemical information and modeling 17915856 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/17915856
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Mutafova-Yambolieva, Violeta N; Hwang, Sung Jin; Hao, Xuemei; Chen, Hui; Zhu, Michael X; Wood, Jackie D; Ward, Sean M; Sanders, Kenton M Proceedings of the National Academy of Sciences of the United States of America 17913880 2007 Oct 9 https://www.ncbi.nlm.nih.gov/pubmed/17913880
A library of 3-aryl-4,5-dihydroisoxazole-5-carboxamides. Jeddeloh, Melissa R; Holden, Jason B; Nouri, Dustin H; Kurth, Mark J Journal of combinatorial chemistry 17910514 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/17910514
Efficient solid-phase synthesis of 3-substituted-5-oxo-5H-thiazolo[2,3-b]-quinazoline-8-carboxamides under mild conditions with two diversity positions. Bouillon, Isabelle; Krchnak, Viktor Journal of combinatorial chemistry 17907790 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/17907790
Tunable photoactivation of a post-translationally modified signaling protein and its unmodified counterpart in live cells. Hahn, Michael E; Pellois, Jean-Philippe; Vila-Perello, Miquel; Muir, Tom W Chembiochem : a European journal of chemical biology 17907120 2007 Nov 23 https://www.ncbi.nlm.nih.gov/pubmed/17907120
Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Wu, Yang; Buranda, Tione; Simons, Peter C; Lopez, Gabriel P; McIntire, William E; Garrison, James C; Prossnitz, Eric R; Sklar, Larry A Analytical biochemistry 17904091 2007 Dec 1 https://www.ncbi.nlm.nih.gov/pubmed/17904091
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Martin, Brent R; Deerinck, Thomas J; Ellisman, Mark H; Taylor, Susan S; Tsien, Roger Y Chemistry & biology 17884635 2007 Sep https://www.ncbi.nlm.nih.gov/pubmed/17884635
Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. Schroeder, Friedhelm; Petrescu, Anca D; Huang, Huan; Atshaves, Barbara P; McIntosh, Avery L; Martin, Gregory G; Hostetler, Heather A; Vespa, Aude; Landrock, Danilo; Landrock, Kerstin K; Payne, H Ross; Kier, Ann B Lipids 17882463 2008 Jan https://www.ncbi.nlm.nih.gov/pubmed/17882463
Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads. Buranda, Tione; Waller, Anna; Wu, Yang; Simons, Peter C; Biggs, Sean; Prossnitz, Eric R; Sklar, Larry A Advances in protein chemistry 17854656 2007 https://www.ncbi.nlm.nih.gov/pubmed/17854656
Ligand-based virtual screening by novelty detection with self-organizing maps. Hristozov, Dimitar; Oprea, Tudor I; Gasteiger, Johann Journal of chemical information and modeling 17854167 2007 Nov-Dec https://www.ncbi.nlm.nih.gov/pubmed/17854167
Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides. Lory, Pedro M J; Estrella-Jimenez, Maria E; Shashack, Matthew J; Lokesh, Ganesh L; Natarajan, Amarnath; Gilbertson, Scott R Bioorganic & medicinal chemistry letters 17826998 2007 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/17826998
Fluorescent protein FRET: the good, the bad and the ugly. Piston, David W; Kremers, Gert-Jan Trends in biochemical sciences 17764955 2007 Sep https://www.ncbi.nlm.nih.gov/pubmed/17764955
Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF). Shibano, Makio; Lin, An-Shen; Itokawa, Hideji; Lee, Kuo-Hsiung Journal of natural products 17764149 2007 Sep https://www.ncbi.nlm.nih.gov/pubmed/17764149
Development of Tyrocidine A analogues with improved antibacterial activity. Marques, Michael A; Citron, Diane M; Wang, Clay C Bioorganic & medicinal chemistry 17728134 2007 Nov 1 https://www.ncbi.nlm.nih.gov/pubmed/17728134
Molecular profiling of single cancer cells and clinical tissue specimens with semiconductor quantum dots. Xing, Yun; Smith, Andrew M; Agrawal, Amit; Ruan, Gang; Nie, Shuming International journal of nanomedicine 17722280 2006 https://www.ncbi.nlm.nih.gov/pubmed/17722280
Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions. Angell, Yu L; Burgess, Kevin Chemical Society reviews 17721589 2007 Oct https://www.ncbi.nlm.nih.gov/pubmed/17721589
Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Sun, Mei G; Williams, James; Munoz-Pinedo, Cristina; Perkins, Guy A; Brown, Joshua M; Ellisman, Mark H; Green, Douglas R; Frey, Terrence G Nature cell biology 17721514 2007 Sep https://www.ncbi.nlm.nih.gov/pubmed/17721514
Photophysical properties of acene DCDHF fluorophores: long-wavelength single-molecule emitters designed for cellular imaging. Lord, Samuel J; Lu, Zhikuan; Wang, Hui; Willets, Katherine A; Schuck, P James; Lee, Hsiao-lu D; Nishimura, Stefanie Y; Twieg, Robert J; Moerner, W E The journal of physical chemistry. A 17718454 2007 Sep 20 https://www.ncbi.nlm.nih.gov/pubmed/17718454
Quantum dot-based sensor for improved detection of apoptotic cells. Koeppel, Florence; Jaiswal, Jyoti K; Simon, Sanford M Nanomedicine (London, England) 17716192 2007 Feb https://www.ncbi.nlm.nih.gov/pubmed/17716192
Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Rhyner, Matthew N; Smith, Andrew M; Gao, Xiaohu; Mao, Hui; Yang, Lily; Nie, Shuming Nanomedicine (London, England) 17716110 2006 Aug https://www.ncbi.nlm.nih.gov/pubmed/17716110
Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes. Jaiswal, Jyoti K; Fix, Marina; Takano, Takahiro; Nedergaard, Maiken; Simon, Sanford M Proceedings of the National Academy of Sciences of the United States of America 17715060 2007 Aug 28 https://www.ncbi.nlm.nih.gov/pubmed/17715060
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Xiao, Rui; Tian, Jinbin; Tang, Jisen; Zhu, Michael X Cell calcium 17706768 2008 Apr https://www.ncbi.nlm.nih.gov/pubmed/17706768
Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase. Talukdar, Arindam; Illarionov, Boris; Bacher, Adelbert; Fischer, Markus; Cushman, Mark The Journal of organic chemistry 17696548 2007 Sep 14 https://www.ncbi.nlm.nih.gov/pubmed/17696548
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. Ma, Suzanne M; Zhan, Jixun; Watanabe, Kenji; Xie, Xinkai; Zhang, Wenjun; Wang, Clay C; Tang, Yi Journal of the American Chemical Society 17696354 2007 Sep 5 https://www.ncbi.nlm.nih.gov/pubmed/17696354
Combined 4D-fingerprint and clustering based membrane-interaction QSAR analyses for constructing consensus Caco-2 cell permeation virtual screens. Santos-Filho, Osvaldo A; Hopfinger, Anton J Journal of pharmaceutical sciences 17696143 2008 Jan https://www.ncbi.nlm.nih.gov/pubmed/17696143
Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Peng, Lee F; Kim, Sun Suk; Matchacheep, Sirinya; Lei, Xiaoguang; Su, Shun; Lin, Wenyu; Runguphan, Weerawat; Choe, Won-Hyeok; Sakamoto, Naoya; Ikeda, Masanori; Kato, Nobuyuki; Beeler, Aaron B; Porco Jr, John A; Schreiber, Stuart L; Chung, Raymond T Antimicrobial agents and chemotherapy 17682098 2007 Oct https://www.ncbi.nlm.nih.gov/pubmed/17682098
Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina. Devonshire, A L; Heidari, R; Huang, H Z; Hammock, B D; Russell, R J; Oakeshott, J G Insect biochemistry and molecular biology 17681228 2007 Sep https://www.ncbi.nlm.nih.gov/pubmed/17681228
Open, reconfigurable cytometric acquisition system: ORCAS. Naivar, Mark A; Parson, Jimmie D; Wilder, Mark E; Habbersett, Robert C; Edwards, Bruce S; Sklar, Larry; Nolan, John P; Graves, Steven W; Martin, John C; Jett, James H; Freyer, James P Cytometry. Part A : the journal of the International Society for Analytical Cytology 17680705 2007 Nov https://www.ncbi.nlm.nih.gov/pubmed/17680705
Efficient solid-phase synthesis of 2-substituted-3-hydroxy-4(1H)-quinolinone-7-carboxamides with two diversity positions. Soural, Miroslav; Krchnak, Viktor Journal of combinatorial chemistry 17676809 2007 Sep-Oct https://www.ncbi.nlm.nih.gov/pubmed/17676809
Categorical QSAR Models for skin sensitization based upon local lymph node assay classification measures part 2: 4D-fingerprint three-state and two-2-state logistic regression models. Li, Yi; Pan, Dahua; Liu, Jianzhong; Kern, Petra S; Gerberick, G Frank; Hopfinger, Anton J; Tseng, Yufeng J Toxicological sciences : an official journal of the Society of Toxicology 17675333 2007 Oct https://www.ncbi.nlm.nih.gov/pubmed/17675333
New directions in single-molecule imaging and analysis. Moerner, W E Proceedings of the National Academy of Sciences of the United States of America 17664434 2007 Jul 31 https://www.ncbi.nlm.nih.gov/pubmed/17664434
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The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Kimple, Adam J; Willard, Francis S; Giguere, Patrick M; Johnston, Christopher A; Mocanu, Viorel; Siderovski, David P Biochimica et biophysica acta 17660054 2007 Sep https://www.ncbi.nlm.nih.gov/pubmed/17660054
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A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. Park, Jun Y; Arnaout, M Amin; Gupta, Vineet Journal of biomolecular screening 17438069 2007 Apr https://www.ncbi.nlm.nih.gov/pubmed/17438069
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