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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Authors Journal PubMedID Publication Date
A Novel Inhibitor of Alpha- Galactosidase Identified from a Compound Library Screen Motabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng W Current Chemical Genomics 999999929 2010
Fluorescence polarization assays in small molecule screening Lea, W. L., and Simeonov, A. Expert Op Drug Disc 999999928 2011
The Ups and Downs of Structure-Activity Landscapes Guha R. Methods Mol Biol. 999999927 2011
The Ups and Downs of Structure-Activity Landscapes Guha R. Cheminformatics and Computational Chemical Biology 999999926 2011
Understanding Enzymes as Reporters or Targets in Assays Using Quantitative High-Throughput Screening (qHTS) Auld DS, Thorne N, Boxer MB, Southall N, Shen M, Thomas CJ, Inglese J 4th International ESCEC Symposium on Experimental Standard Conditions of Enzyme Characterizations 999999925 2010
Identification and validation of clinically utilized drugs for the treatment of adrenocortical cancer Nilubol N, Zhang L, Shen M, Zhang Y-Q, He M, Kebebew E Endocrine-Related Cancer 999999924 2012
Interplay between Tdp1, CtIP and PARP for the Repair of Topoisomerase I and II-induced DNA Damage in Vertebrate Cells Murai J, Huang S-Y N, Das BB, Dexheimer TS, Takeda S, Pommier Y PloS Genetics 999999923 2012
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase Morgan HP, Walsh M, Boxer M, Shen M, Blackburn EA, Wear MA, McNae IW, Nowicki MW, Michels P A-M, Auld DS, Fothergill-Gilmore LA & Walkinshaw MD J. Biological Chemistry 999999922 2012
NRG1-ErbB4-p110δ signaling in schizophrenia. Reversal of amphetamine-induced behaviors by selective p110δ inhibition Law AJ, Wang Y, Sei Y, Papaleo F, Huang W, Thomas CJ, Austin CP, Harrison PJ, Lipska BK, Hyde TM, Kleinman JE, Weinberger DR Proc Natl Acad Sci USA 999999921 2012
Physiopathological role of the Neuropeptide S system in cocaine relapse: A mechanism mediated by the hypothalamic hypocretin system Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R Proc Natl Acad Sci USA 999999920 2010
Computational approaches in cheminformatics and bioinformatics Guha R, Bender A. 1st ed Hoboken 999999919 2012
Exploring Structure-activity-relationships to design novel drugs Guha, R. Silico Models for Drug Discovery 999999918 2012
Selecting, acquiring and using small molecule libraries for high-throughput screening Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ Curr. Prot. Chem. Biol. 999999917 2012
A High Affinity αIIbβ3 Antagonist Displays a Novel Mechanism of Inhibiting Ligand Binding, Competing with Mg2+ for Interacting with the MIDAS Glu220 Choi W-S, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Zhu J, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS Nat. Struct. Mol. Biol. 999999916 2011
Molecular Sensors for Transcriptional and Post-Transcriptional Assays Auld DS & Thorne N Chemical Genomics 999999915 2011
Urotensin-II Receptor Antagonists: From Peptides to Small-Molecules. Assessment of Potency, Selectivity, and In Vitro ADME Properties Luci D, Maloney D Diane Luci: ACS 999999914 2011
Chapter 16. Tyrosyl DNA-phosphodiesterase Dexheimer TS, Huang S-YN, Das BB, Pommier Y DNA Topoisomerases and Cancer. Cancer Drug Discovery and Development 999999913 2012
Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New Bioactive Compounds Benson SC, Lee L, Wei W, Ni F, Olmos JDJ, Strom KR, Beeler AB, Cheng KC-C, Inglese J, Kota S, Takahashi V, Strosberg AD, Connor JH, Bushkin GG, Snyder JK Heterocycles 999999912 2011
On Exploring Structure Activity Relationships Guha R Silico Models for Drug Discovery 999999911 2013
Decreased Subcutaneous Bioavailability of an Oxyntomodulin Analog in a Controlled Release Formulation could be Caused by Skin Metabolism in Rats Wang M, Defranco D, Wright K, Quazi S, Chen J, Spencer-Pierce J, Zaghloul I, Pak R, Darvari R, Krishnan A, Perreault M, Sun L, Ozer J, O’Hara D, Rup B, and Xu X J Bioequiv Availab 999999910 2012
Perspectives and Challenges in Epigenetic Therapy: DNA Methylation in Cancer Stem Cells. Book Chapter in: DNA Methylation: Principles, Mechanisms and Challenges Sun L, Yang A, Cabarcas SM, Mathews LA, Farrar W Nova Science Publisher 999999909 2013
Pharmaceutical Profiling Case Study in Disruption Kerns, EH. ACS Med Chem Lett 999999908 2013
CD28-ITK signals regulate autoreactive T cell trafficking into tissues Jain M, Jiang J-k, Greiner D, Thomas CJ, Berg LJ, Kang J The Journal of Immunology 999999907 2012
Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP Johnson RL, Huang W Littman DR ACS Med Chem Lett. 999999906 2012
Dealing with the Data Deluge: Handling the Multitude Of Chemical Biology Data Sources Guha R, Nguyen D-T, Southall N, Jadhav A Current Protocols in Chemical Biology 999999905 2012
Exploring Structure-Activity Data Using the Landscape Paradigm Guha WIREs Comput Mol Sci, 2 999999904 2012
Reply to Kojo: Mechanisms of antioxidant-induced DNA damage Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K Proc Natl Acad Sci USA 999999903 2012
Selecting, acquiring and using small molecule libraries for high-throughput screening Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ Current Protocols in Chemical Biology 999999902 2012
Toxicity testing with Heparg spheroids Auld DS, Lea W, Davis MI, Simeonov A ASSAY and Drug Development Technologies 999999901 2012
A proteomics landscape of circadian clock in mouse liver. Wang, Yunzhi; Song, Lei; Liu, Mingwei; Ge, Rui; Zhou, Quan; Liu, Wanlin; Li, Ruiyang; Qie, Jingbo; Zhen, Bei; Wang, Yi; He, Fuchu; Qin, Jun; Ding, Chen Nature communications. 29674717 2018 Apr 19;
Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition. Koplev, Simon; Lin, Katie; Dohlman, Anders B; Ma'ayan, Avi PLoS computational biology. 29293502 2018 01;
D4dopamine receptor high-resolution structures enable the discovery of selective agonists. Wang, Sheng; Wacker, Daniel; Levit, Anat; Che, Tao; Betz, Robin M; McCorvy, John D; Venkatakrishnan, A J; Huang, Xi-Ping; Dror, Ron O; Shoichet, Brian K; Roth, Bryan L Science (New York, N.Y.). 29051383 2017 10 20;
Systems Medicine Approaches to Improving Understanding, Treatment, and Clinical Management of Neuroendocrine Prostate Cancer. Yadav, Kamlesh K; Shameer, Khader; Readhead, Ben; Yadav, Shalini S; Li, Li; Kasarskis, Andrew; Tewari, Ashutosh K; Dudley, Joel T Current pharmaceutical design. 27174811 2016;
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Vardy, Eyal; Sassano, Maria F; Rennekamp, Andrew J; Kroeze, Wesley K; Mosier, Philip D; Westkaemper, Richard B; Stevens, Craig W; Katritch, Vsevolod; Stevens, Raymond C; Peterson, Randall T; Roth, Bryan L Chemistry & biology. 26091169 2015 Jun 18;
Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors. Tsai, Yihsuan S; Dominguez, Daniel; Gomez, Shawn M; Wang, Zefeng Oncotarget. 25749525 2015 Mar 30;
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. Duarte, Luis F; Young, Andrew R J; Wang, Zichen; Wu, Hsan-Au; Panda, Taniya; Kou, Yan; Kapoor, Avnish; Hasson, Dan; Mills, Nicholas R; Ma'ayan, Avi; Narita, Masashi; Bernstein, Emily Nature communications. 25394905 2014;
A blueprint of cell identity. Ma'ayan, Avi; Duan, Qiaonan Nature biotechnology. 25299921 2014 Oct;
Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment. Petrukhin, Konstantin Drug discovery today. Therapeutic strategies 25152755 2013
Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification. Sahn, James J; Granger, Brett A; Martin, Stephen F Organic & biomolecular chemistry 25135846 2014 Aug 19
Biomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes. Yu, Yi-Yun; Georg, Gunda I Advanced synthesis & catalysis 25071423 2014 Apr 14
A high throughput flow cytometric assay platform targeting transporter inhibition. Tegos, George P; Evangelisti, Annette M; Strouse, J Jacob; Ursu, Oleg; Bologa, Cristian; Sklar, Larry A Drug discovery today. Technologies 25027381 2014 Jun
Synthesis of the rosette-inducing factor RIF-1 and analogs. Beemelmanns, Christine; Woznica, Arielle; Alegado, Rosanna A; Cantley, Alexandra M; King, Nicole; Clardy, Jon Journal of the American Chemical Society 24983513 2014 Jul 23
Lifting the mask: identification of new small molecule inhibitors of uropathogenic Escherichia coli group 2 capsule biogenesis. Goller, Carlos C; Arshad, Mehreen; Noah, James W; Ananthan, Subramaniam; Evans, Carrie W; Nebane, N Miranda; Rasmussen, Lynn; Sosa, Melinda; Tower, Nichole A; White, E Lucile; Neuenswander, Benjamin; Porubsky, Patrick; Maki, Brooks E; Rogers, Steven A; Sc PloS one 24983234 2014
Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons. Parks, Gregory S; Wang, Lien; Wang, Zhiwei; Civelli, Olivier The Journal of comparative neurology 24978951 2014 Jun 30
Exploiting the Divalent Nature of Isonitriles: a novel Pictet-Spengler Amidination process. Medda, Federico; Hulme, Christopher Tetrahedron letters 24954960 2014 May 1
Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. Sully, Erin K; Malachowa, Natalia; Elmore, Bradley O; Alexander, Susan M; Femling, Jon K; Gray, Brian M; DeLeo, Frank R; Otto, Michael; Cheung, Ambrose L; Edwards, Bruce S; Sklar, Larry A; Horswill, Alexander R; Hall, Pamela R; Gresham, Hattie D PLoS pathogens 24945495 2014 Jun
Novel succinct routes to Quinoxalines and 2-Benzimidazolylquinoxalines via the Ugi reaction. Ayaz, Muhammad; Xu, Zhigang; Hulme, Christopher Tetrahedron letters 24932052 2014 Jun 4
Enzyme inhibitor discovery by activity-based protein profiling. Niphakis, Micah J; Cravatt, Benjamin F Annual review of biochemistry 24905785 2014
Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. Du, Lin; Robles, Andrew J; King, Jarrod B; Mooberry, Susan L; Cichewicz, Robert H Journal of natural products 24893224 2014 Jun 27
Thielavialides A-E, nor-spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, an endophytic fungus isolated from aeroponically grown Physalis alkekengi. Wijeratne, E M Kithsiri; Espinosa-Artiles, Patricia; Gruener, Raphael; Gunatilaka, A A Leslie Journal of natural products 24882589 2014 Jun 27
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. Chou, Tsui-Fen; Bulfer, Stacie L; Weihl, Conrad C; Li, Kelin; Lis, Lev G; Walters, Michael A; Schoenen, Frank J; Lin, Henry J; Deshaies, Raymond J; Arkin, Michelle R Journal of molecular biology 24878061 2014 Jul 29
A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor. Conn, P Michael; Smith, Emery; Spicer, Timothy; Chase, Peter; Scampavia, Louis; Janovick, Jo Ann Assay and drug development technologies 24831790 2014 May
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sun, Haiyan; Wei, Ying; Deng, Huayun; Xiong, Qiaojie; Li, Min; Lahiri, Joydeep; Fang, Ye Scientific reports 24816792 2014
Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. Low, Yen Sia; Sedykh, Alexander Yeugenyevich; Rusyn, Ivan; Tropsha, Alexander Current topics in medicinal chemistry 24805064 2014
Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu2/mGlu3 NAMs. Wenthur, Cody J; Morrison, Ryan D; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W Bioorganic & medicinal chemistry letters 24794112 2014 Jun 15
Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella. Kwan, Jason C; Tianero, Ma Diarey B; Donia, Mohamed S; Wyche, Thomas P; Bugni, Tim S; Schmidt, Eric W PloS one 24788869 2014
Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions. Martinez-Ariza, Guillermo; Ayaz, Muhammad; Medda, Federico; Hulme, Christopher The Journal of organic chemistry 24788091 2014 Jun 6
Enantioselective synthesis of 3,4-dihydro-1,2-oxazepin-5(2H)-ones and 2,3-dihydropyridin-4(1H)-ones from *-substituted *-hydroxyaminoaldehydes. Ranade, Adwait R; Georg, Gunda I The Journal of organic chemistry 24785413 2014 Feb 7
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. Abulwerdi, Fardokht A; Liao, Chenzhong; Mady, Ahmed S; Gavin, Jordan; Shen, Chenxi; Cierpicki, Tomasz; Stuckey, Jeanne A; Showalter, H D Hollis; Nikolovska-Coleska, Zaneta Journal of medicinal chemistry 24749893 2014 May 22
Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. Yan, Fei; Yu, Yang; Chow, Dar-Chone; Palzkill, Timothy; Madoux, Franck; Hodder, Peter; Chase, Peter; Griffin, Patrick R; O'Malley, Bert W; Lonard, David M PloS one 24743578 2014
Protein chaperones: a composition of matter review (2008 - 2013). Taldone, Tony; Patel, Hardik J; Bolaender, Alexander; Patel, Maulik R; Chiosis, Gabriela Expert opinion on therapeutic patents 24742089 2014 May
Solvent-dependent divergent functions of Sc(OTf)ýýý in stereoselective epoxide-opening spiroketalizations. Sharma, Indrajeet; Wurst, Jacqueline M; Tan, Derek S Organic letters 24742081 2014 May 2
Host endothelial S1PR1 regulation of vascular permeability modulates tumor growth. Sarkisyan, Gor; Gay, Laurie J; Nguyen, Nhan; Felding, Brunhilde H; Rosen, Hugh American journal of physiology. Cell physiology 24740542 2014 Jul 1
Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. Oldstone, Michael B A; Rosen, Hugh Current topics in microbiology and immunology 24728596 2014
Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics. Swale, Daniel R; Kharade, Sujay V; Denton, Jerod S Current opinion in pharmacology 24721648 2014 Apr
Evaluation of prostate-specific membrane antigen as an imaging reporter. Castanares, Mark A; Mukherjee, Amarnath; Chowdhury, Wasim H; Liu, Minzhi; Chen, Ying; Mease, Ronnie C; Wang, Yuchuan; Rodriguez, Ronald; Lupold, Shawn E; Pomper, Martin G Journal of nuclear medicine : official publication, Society of Nuclear Medicine 24700883 2014 May
Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5 -Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe. Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P Jef ChemMedChem 24692176 2014 Apr 1
Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. Gavrish, Ekaterina; Sit, Clarissa S; Cao, Shugeng; Kandror, Olga; Spoering, Amy; Peoples, Aaron; Ling, Losee; Fetterman, Ashley; Hughes, Dallas; Bissell, Anthony; Torrey, Heather; Akopian, Tatos; Mueller, Andreas; Epstein, Slava; Goldberg, Alfred; Clardy, Chemistry & biology 24684906 2014 Apr 24
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. Rai, Ganesha; Joshi, Netra; Jung, Joo Eun; Liu, Yu; Schultz, Lena; Yasgar, Adam; Perry, Steve; Diaz, Giovanni; Zhang, Qiangli; Kenyon, Victor; Jadhav, Ajit; Simeonov, Anton; Lo, Eng H; van Leyen, Klaus; Maloney, David J; Holman, Theodore R Journal of medicinal chemistry 24684213 2014 May 22
Protein phosphatases in pancreatic islets. Ortsater, Henrik; Grankvist, Nina; Honkanen, Richard E; Sjoholm, Ake The Journal of endocrinology 24681827 2014 Jun
Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. Walsh, Kevin B; Teijaro, John R; Brock, Linda G; Fremgen, Daniel M; Collins, Peter L; Rosen, Hugh; Oldstone, Michael B A Journal of virology 24672024 2014 Jun
The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions. Prohaska, Kimberly M; Bennett, Ryan P; Salter, Jason D; Smith, Harold C Wiley interdisciplinary reviews. RNA 24664896 2014 Mar 24
Synthesis of novel peptidyl adenosine antibiotic analogs. Moukha-Chafiq, Omar; Reynolds, Robert C Nucleosides, nucleotides & nucleic acids 24660880 2014
Boron-Heck reaction of cyclic enaminones: regioselective direct arylation via oxidative palladium(II) catalysis. Kim, Yong Wook; Georg, Gunda I Organic letters 24650204 2014 Mar 21
In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4. Mandal, Nawajes A; Tran, Julie-Thu A; Zheng, Lixin; Wilkerson, Joseph L; Brush, Richard S; McRae, Joel; Agbaga, Martin-Paul; Zhang, Kang; Petrukhin, Konstantin; Ayyagari, Radha; Anderson, Robert E Investigative ophthalmology & visual science 24644051 2014 Apr
A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence. Vekariya, Rakesh H; Liu, Ruzhang; Aube, Jeffrey Organic letters 24635056 2014 Apr 4
Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives. Pagano, Nicholas; Heil, Marintha L; Cosford, Nicholas D P Synthesis 24634547 2012
Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Yuan, Hsiangkuo; Wilson, Christy M; Xia, Jun; Doyle, Sarah L; Li, Shuqin; Fales, Andrew M; Liu, Yang; Ozaki, Ema; Mulfaul, Kelly; Hanna, Gabi; Palmer, Gregory M; Wang, Lihong V; Grant, Gerald A; Vo-Dinh, Tuan Nanoscale 24619405 2014 Apr 21
Equilibrium and kinetics of Sin Nombre hantavirus binding at DAF/CD55 functionalized bead surfaces. Buranda, Tione; Swanson, Scarlett; Bondu, Virginie; Schaefer, Leah; Maclean, James; Mo, Zhenzhen; Wycoff, Keith; Belle, Archana; Hjelle, Brian Viruses 24618810 2014
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Ziemert, Nadine; Lechner, Anna; Wietz, Matthias; Millan-Aguinaga, Natalie; Chavarria, Krystle L; Jensen, Paul Robert Proceedings of the National Academy of Sciences of the United States of America 24616526 2014 Mar 25
A chimeric siderophore halts swarming Vibrio. Bottcher, Thomas; Clardy, Jon Angewandte Chemie (International ed. in English) 24615751 2014 Mar 24
Discovery of ML314, a Brain Penetrant Non-Peptidic *-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Maloney, Patrick R; Li, Yujie; Milewski, Monika; Gosalia, Palak; Gray, Wilson; Mehta, Alka; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Heynen-Genel, Susanne; Vasile, Stefa ACS medicinal chemistry letters 24611085 2013 Jul 20
Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: Immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy. Teijaro, John R; Walsh, Kevin B; Long, James P; Tordoff, Kevin P; Stark, Gregory V; Eisfeld, Amie J; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B A Virology 24606692 2014 Mar
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors. Brahimi, Fouad; Ko, Eunhwa; Malakhov, Andrey; Burgess, Kevin; Saragovi, H Uri PloS one 24603864 2014
Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Kwan, Jason C; Liu, Yanxia; Ratnayake, Ranjala; Hatano, Ryo; Kuribara, Akiko; Morimoto, Chiko; Ohnuma, Kei; Paul, Valerie J; Ye, Tao; Luesch, Hendrik Chembiochem : a European journal of chemical biology 24591193 2014 Apr 14
Pharmacologic repression of retinoic acid receptor-related orphan nuclear receptor ýý is therapeutic in the collagen-induced arthritis experimental model. Chang, Mi Ra; Lyda, Brent; Kamenecka, Theodore M; Griffin, Patrick R Arthritis & rheumatology (Hoboken, N.J.) 24574218 2014 Mar
Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Gonzalez, David J; Vuong, Lisa; Gonzalez, Isaiah S; Keller, Nadia; McGrosso, Dominic; Hwang, John H; Hung, Jun; Zinkernagel, Annelies; Dixon, Jack E; Dorrestein, Pieter C; Nizet, Victor Molecular & cellular proteomics : MCP 24567418 2014 May
Diastereoselective synthesis of ýý- and ýý-lactams from imines and sulfone-substituted anhydrides. Sorto, Nohemy A; Di Maso, Michael J; Munoz, Manuel A; Dougherty, Ryan J; Fettinger, James C; Shaw, Jared T The Journal of organic chemistry 24552208 2014 Mar 21
MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines. Bell, Christan E; Shaw, Arthur Y; De Moliner, Fabio; Hulme, Christopher Tetrahedron 24535889 2014 Jan 7
Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp. Ellis, Gregory A; Wyche, Thomas P; Fry, Charles G; Braun, Doug R; Bugni, Tim S Marine drugs 24534844 2014 Feb
Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site. Gregory, Karen J; Nguyen, Elizabeth D; Malosh, Chrysa; Mendenhall, Jeffrey L; Zic, Jessica Z; Bates, Brittney S; Noetzel, Meredith J; Squire, Emma F; Turner, Eric M; Rook, Jerri M; Emmitte, Kyle A; Stauffer, Shaun R; Lindsley, Craig W; Meiler, Jens; Conn, ACS chemical neuroscience 24528109 2014 Apr 16
M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses. Pancani, Tristano; Bolarinwa, Caroline; Smith, Yoland; Lindsley, Craig W; Conn, P Jeffrey; Xiang, Zixiu ACS chemical neuroscience 24528004 2014 Apr 16
Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. Bandyopadhyay, Sanghamitra; Rogers, Jack T Biochemical pharmacology 24513321 2014 Apr 15
Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor. Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry A Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 24510772 2014
Real-Time Detection of Protein Trafficking with High-Throughput Flow Cytometry (HTFC) and Fluorogen-Activating Protein (FAP) Base Biosensor. Wu, Yang; Tapia, Phillip H; Jarvik, Jonathan; Waggoner, Alan S; Sklar, Larry A Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 24510772 2014
Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Xie, Pengfei; Ma, Ming; Rateb, Mostafa E; Shaaban, Khaled A; Yu, Zhiguo; Huang, Sheng-Xiong; Zhao, Li-Xing; Zhu, Xiangcheng; Yan, Yijun; Peterson, Ryan M; Lohman, Jeremy R; Yang, Dong; Yin, Min; Rudolf, Jeffrey D; Jiang, Yi; Duan, Yanwen; Shen, Ben Journal of natural products 24484381 2014 Feb 28
Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions. Neochoritis, Constantinos G; Domling, Alexander Organic & biomolecular chemistry 24477767 2014 Mar 14
Programmed death-1: therapeutic success after more than 100ýýýyears of cancer immunotherapy. Domling, Alexander; Holak, Tad A Angewandte Chemie (International ed. in English) 24474145 2014 Feb 24
Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. Fan, Longchang; Guan, Xiaowei; Wang, Wei; Zhao, Jian-Yuan; Zhang, Hongkang; Tiwari, Vinod; Hoffman, Paul N; Li, Min; Tao, Yuan-Xiang Molecular pain 24472174 2014
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. He, Shihan; Senter, Timothy J; Pollock, Jonathan; Han, Changho; Upadhyay, Sunil Kumar; Purohit, Trupta; Gogliotti, Rocco D; Lindsley, Craig W; Cierpicki, Tomasz; Stauffer, Shaun R; Grembecka, Jolanta Journal of medicinal chemistry 24472025 2014 Feb 27
Chemo- and site-selective derivatizations of natural products enabling biological studies. Robles, Omar; Romo, Daniel Natural product reports 24468713 2014 Mar
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. Gao, Wei; Sun, Hai-Xi; Xiao, Hongbin; Cui, Guanghong; Hillwig, Matthew L; Jackson, Alana; Wang, Xiao; Shen, Ye; Zhao, Nan; Zhang, Liangxiao; Wang, Xiu-Jie; Peters, Reuben J; Huang, Luqi BMC genomics 24467826 2014
A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. Lewallen, Daniel M; Bicker, Kevin L; Madoux, Franck; Chase, Peter; Anguish, Lynne; Coonrod, Scott; Hodder, Peter; Thompson, Paul R ACS chemical biology 24467619 2014 Apr 18
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. Sheffler, Douglas J; Nedelovych, Michael T; Williams, Richard; Turner, Stephen C; Duerk, Brittany B; Robbins, Megan R; Jadhav, Sataya B; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Daniels, R Nathan; Lindsley, Craig W Bioorganic & medicinal chemistry letters 24462664 2014 Feb 15
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. Jones, Carrie K; Sheffler, Douglas J; Williams, Richard; Jadhav, Sataya B; Felts, Andrew S; Morrison, Ryan D; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W Bioorganic & medicinal chemistry letters 24461352 2014 Feb 15
A novel class of ion displacement ligands as antagonists of the *IIb*3 receptor that limit conformational reorganization of the receptor. Jiang, Jian-kang; McCoy, Joshua G; Shen, Min; LeClair, Christopher A; Huang, Wenwei; Negri, Ana; Li, Jihong; Blue, Robert; Harrington, Amanda Weil; Naini, Sarasija; David 3rd, George; Choi, Won-Seok; Volpi, Elisabetta; Fernandez, Joseph; Babayeva, Mariana Bioorganic & medicinal chemistry letters 24461295 2014 Feb 15
Probing chemical space with alkaloid-inspired libraries. McLeod, Michael C; Singh, Gurpreet; Plampin 3rd, James N; Rane, Digamber; Wang, Jenna L; Day, Victor W; Aube, Jeffrey Nature chemistry 24451589 2014 Feb
Chemical modulation of glycerolipid signaling and metabolic pathways. Scott, Sarah A; Mathews, Thomas P; Ivanova, Pavlina T; Lindsley, Craig W; Brown, H Alex Biochimica et biophysica acta 24440821 2014 Jan 15
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Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. Raphemot, Rene; Kadakia, Rishin J; Olsen, Michelle L; Banerjee, Sreedatta; Days, Emily; Smith, Stephen S; Weaver, C David; Denton, Jerod S Assay and drug development technologies 24266659 2013 Nov-Dec
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Secoemestrin D, a Cytotoxic Epitetrathiodioxopiperizine, and Emericellenes A-E, Five Sesterterpenoids from Emericella sp. AST0036, a Fungal Endophyte of Astragalus lentiginosus1. Xu, Ya-Ming; Espinosa-Artiles, Patricia; Liu, Mangping X; Arnold, A Elizabeth; Gunatilaka, A A Leslie Journal of natural products 24251417 2013 Nov 19
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Metabolic imaging of patients with prostate cancer using hyperpolarized [1-ýýýýC]pyruvate. Nelson, Sarah J; Kurhanewicz, John; Vigneron, Daniel B; Larson, Peder E Z; Harzstark, Andrea L; Ferrone, Marcus; van Criekinge, Mark; Chang, Jose W; Bok, Robert; Park, Ilwoo; Reed, Galen; Carvajal, Lucas; Small, Eric J; Munster, Pamela; Weinberg, Vivian K Science translational medicine 23946197 2013 Aug 14
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An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins. Gao, Xue; Jiang, Wei; Jimenez-Oses, Gonzalo; Choi, Moon Seok; Houk, Kendall N; Tang, Yi; Walsh, Christopher T Chemistry & biology 23890005 2013 Jul 25
pCAP-based peptide substrates: The new tool in the box of tyrosine phosphatase assays. Stanford, Stephanie M; Krishnamurthy, Divya; Kulkarni, Rhushikesh A; Karver, Caitlin E; Bruenger, Eveline; Walker, Logan M; Ma, Chen-Ting; Chung, Thomas D Y; Sergienko, Eduard; Bottini, Nunzio; Barrios, Amy M Methods (San Diego, Calif.) 23886911 2013 Jul 22
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Production of ýý-galactosylceramide by a prominent member of the human gut microbiota. Wieland Brown, Laura C; Penaranda, Cristina; Kashyap, Purna C; Williams, Brianna B; Clardy, Jon; Kronenberg, Mitchell; Sonnenburg, Justin L; Comstock, Laurie E; Bluestone, Jeffrey A; Fischbach, Michael A PLoS biology 23874157 2013 Jul
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A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Satsu, Hideo; Schaeffer, Marie-Therese; Guerrero, Miguel; Saldana, Adrian; Eberhart, Christina; Hodder, Peter; Cayanan, Charmagne; Schurer, Stephan; Bhhatarai, Barun; Roberts, Ed; Rosen, Hugh; Brown, Steven J Bioorganic & medicinal chemistry 23849205 2013 Sep 1
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Small-molecule procaspase activators identified using fluorescence polarization. Vickers, Chris J; Gonzalez-Paez, Gonzalo E; Umotoy, Jeffrey C; Cayanan-Garrett, Charmagne; Brown, Steven J; Wolan, Dennis W Chembiochem : a European journal of chemical biology 23836614 2013 Aug 19
Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae. Napper, Andrew D; Motlekar, Nuzhat; de Almeida, Rogerio Alves; Pavitt, Graham D Current protocols in chemical biology 23836585 2011 Mar 1
Scaling and systems biology for integrating multiple organs-on-a-chip. Wikswo, John P; Curtis, Erica L; Eagleton, Zachary E; Evans, Brian C; Kole, Ayeeshik; Hofmeister, Lucas H; Matloff, William J Lab on a chip 23828456 2013 Aug 13
Identification of a ýý-ýý opioid receptor heteromer-biased agonist with antinociceptive activity. Gomes, Ivone; Fujita, Wakako; Gupta, Achla; Saldanha, Adrian S; Negri, Ana; Pinello, Christine E; Roberts, Edward; Filizola, Marta; Hodder, Peter; Devi, Lakshmi A Proceedings of the National Academy of Sciences of the United States of America 23818586 2013 Jul 16
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Guo, Juan; Zhou, Yongjin J; Hillwig, Matthew L; Shen, Ye; Yang, Lei; Wang, Yajun; Zhang, Xianan; Liu, Wujun; Peters, Reuben J; Chen, Xiaoya; Zhao, Zongbao K; Huang, Luqi Proceedings of the National Academy of Sciences of the United States of America 23812755 2013 Jul 16
PPAR*-mediated responses in human adult liver stem cells: In vivo/in vitro and cross-species comparisons. Kim, S; Kiyosawa, N; Burgoon, L D; Chang, C C; Zacharewski, T R The Journal of steroid biochemistry and molecular biology 23811191 2013 Nov
Allokutzneria multivorans sp. nov., an actinomycete isolated from soil. Cao, Yan-Ru; Chen, Xiu; Jiang, Yi; Wang, Li-Song; Jiang, Cheng-Lin International journal of systematic and evolutionary microbiology 23811139 2013 Nov
Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas. Yang, Miao; Odelberg, Shannon J; Tong, Zongzhong; Li, Dean Y; Looper, Ryan E Tetrahedron 23807819 2013 Jul 8
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The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands. Li, Ping; Chen, Zhuxi; Xu, Haiyan; Sun, Haifeng; Li, Hao; Liu, Hong; Yang, Huaiyu; Gao, Zhaobing; Jiang, Hualiang; Li, Min Cell research 23797855 2013 Sep
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A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Zhao, Xiuli; Tang, Zongxiang; Zhang, Hongkang; Atianjoh, Fidelis E; Zhao, Jian-Yuan; Liang, Lingli; Wang, Wei; Guan, Xiaowei; Kao, Sheng-Chin; Tiwari, Vinod; Gao, Yong-Jing; Hoffman, Paul N; Cui, Hengmi; Li, Min; Dong, Xinzhong; Tao, Yuan-Xiang Nature neuroscience 23792947 2013 Aug
Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics. Wang, Hsin-Neng; Fales, Andrew M; Zaas, Aimee K; Woods, Christopher W; Burke, Thomas; Ginsburg, Geoffrey S; Vo-Dinh, Tuan Analytica chimica acta 23790305 2013 Jul 5
Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Pinilla, Clemencia; Edwards, Bruce S; Appel, Jon R; Yates-Gibbins, Tina; Giulianotti, Marc A; Medina-Franco, Jose L; Young, Susan M; Santos, Radleigh G; Sklar, Larry A; Houghten, Richard A Molecular pharmacology 23788657 2013 Sep
In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes. McAnally, Danielle; Vicchiarelli, Michael; Siddiquee, Khandaker; Smith, Layton H Current protocols in chemical biology 23788556 2012 Dec 1
Profiling protein methylation with cofactor analog containing terminal alkyne functionality. Blum, Gil; Bothwell, Ian R; Islam, Kabirul; Luo, Minkui Current protocols in chemical biology 23788324 2013 Mar 1
Development of highly selective casein kinase 1ýý/1ýý (CK1ýý/ýý) inhibitors with potent antiproliferative properties. Bibian, Mathieu; Rahaim, Ronald J; Choi, Jun Yong; Noguchi, Yoshihiko; Schurer, Stephan; Chen, Weimin; Nakanishi, Shima; Licht, Konstantin; Rosenberg, Laura H; Li, Lin; Feng, Yangbo; Cameron, Michael D; Duckett, Derek R; Cleveland, John L; Roush, William Bioorganic & medicinal chemistry letters 23787102 2013 Aug 1
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. Yeung, J; Apopa, P L; Vesci, J; Stolla, M; Rai, G; Simeonov, A; Jadhav, A; Fernandez-Perez, P; Maloney, D J; Boutaud, O; Holman, T R; Holinstat, M Thrombosis and haemostasis 23784669 2013 Sep
RanGTP and CLASP1 cooperate to position the mitotic spindle. Bird, Stephen L; Heald, Rebecca; Weis, Karsten Molecular biology of the cell 23783028 2013 Aug
Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets. Young, Summer E; Duvernay, Matthew T; Schulte, Michael L; Lindsley, Craig W; Hamm, Heidi E PloS one 23776495 2013
In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. Wang, Rui; Mason, Daniel E; Choe, Keith P; Lewin, Alfred S; Peters, Eric C; Luesch, Hendrik ACS chemical biology 23773140 2013 Aug 16
Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays. Landry, James P; Fei, Yiyan; Zhu, Xiangdong; Ke, Yaohuang; Yu, Guoliang; Lee, Pierre Assay and drug development technologies 23772553 2013 Jun
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. Xiao, Jingbo; Huang, Zaohua; Chen, Catherine Z; Agoulnik, Irina U; Southall, Noel; Hu, Xin; Jones, Raisa E; Ferrer, Marc; Zheng, Wei; Agoulnik, Alexander I; Marugan, Juan J Nature communications 23764525 2013
Various cyclization scaffolds by a truly Ugi 4-CR. Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, Alexander Organic & biomolecular chemistry 23760036 2013 Jun 13
Synthesis of spirocarbamate oxindoles via intramolecular trapping of a ýý-silyl carbocation by an N-Boc group. Shupe, Benjamin H; Allen, Emily E; MacDonald, Jacob P; Wilson, Sean O; Franz, Annaliese K Organic letters 23758331 2013 Jul 5
Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. Yu, Yi-Yun; Bi, Lei; Georg, Gunda I The Journal of organic chemistry 23750615 2013 Jun 21
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Ardecky, Robert J; Welsh, Kate; Finlay, Darren; Lee, Pooi San; Gonzalez-Lopez, Marcos; Ganji, Santhi Reddy; Ravanan, Palaniyandi; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D P Bioorganic & medicinal chemistry letters 23743278 2013 Jul 15
Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. De, Subhasis; Chen, Lu; Zhang, Shuxing; Gilbertson, Scott R ACS combinatorial science 23742807 2013 Jul 8
A quinazoline-2,4-diamino analog suppresses Vibrio cholerae flagellar motility by interacting with motor protein PomB and induces envelope stress. Wang, Hongxia; Zhang, Li; Silva, Anisia J; Benitez, Jorge A Antimicrobial agents and chemotherapy 23733460 2013 Aug
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. Kaufmann, Kristian; Romaine, Ian; Days, Emily; Pascual, Conrado; Malik, Adam; Yang, Liya; Zou, Bende; Du, Yu; Sliwoski, Greg; Morrison, Ryan D; Denton, Jerod; Niswender, Colleen M; Daniels, J Scott; Sulikowski, Gary A; Xie, Xinmin Simon; Lindsley, Craig W ACS chemical neuroscience 23730969 2013 Sep 18
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Floyd, Scott R; Pacold, Michael E; Huang, Qiuying; Clarke, Scott M; Lam, Fred C; Cannell, Ian G; Bryson, Bryan D; Rameseder, Jonathan; Lee, Michael J; Blake, Emily J; Fydrych, Anna; Ho, Richard; Greenberger, Benjamin A; Chen, Grace C; Maffa, Amanda; Del R Nature 23728299 2013 Jun 13
Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. Scott, Sarah A; Xiang, Yun; Mathews, Thomas P; Cho, Hyekyung P; Myers, David S; Armstrong, Michelle D; Tallman, Keri A; O'Reilly, Matthew C; Lindsley, Craig W; Brown, H Alex The Journal of biological chemistry 23723068 2013 Jul 12
The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors. Santos, Radleigh G; Appel, Jon R; Giulianotti, Marc A; Edwards, Bruce S; Sklar, Larry A; Houghten, Richard A; Pinilla, Clemencia Molecules (Basel, Switzerland) 23722730 2013
Label-free DNA biosensor based on SERS Molecular Sentinel on Nanowave chip. Ngo, Hoan Thanh; Wang, Hsin-Neng; Fales, Andrew M; Vo-Dinh, Tuan Analytical chemistry 23718777 2013 Jul 2
Discovery of (R)-(2-Fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-Hydroxypiperidin-1-yl)methanone (ML337), An mGlu3 Selective and CNS Penetrant Negative Allosteric Modulator (NAM). Wenthur, Cody J; Morrison, Ryan; Felts, Andrew S; Smith, Katrina A; Engers, Julie L; Byers, Frank W; Daniels, J Scott; Emmitte, Kyle A; Conn, P Jeffrey; Lindsley, Craig W Journal of medicinal chemistry 23718281 2013 Jun 27
Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry. Xu, Zhigang; De Moliner, Fabio; Cappelli, Alexandra P; Hulme, Christopher Organic letters 23718233 2013 Jun 7
Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase. Harris, Michael T; Walker, Dawn M; Drew, Mark E; Mitchell, William G; Dao, Kevin; Schroeder, Chad E; Flaherty, Daniel P; Weiner, Warren S; Golden, Jennifer E; Morris, James C Antimicrobial agents and chemotherapy 23716053 2013 Aug
Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. Rateb, Mostafa E; Yu, Zhiguo; Yan, Yijun; Yang, Dong; Huang, Tingting; Vodanovic-Jankovic, Sanja; Kron, Michael A; Shen, Ben The Journal of antibiotics 23715040 2013 May 29
Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. Zhang, Liying; Sedykh, Alexander; Tripathi, Ashutosh; Zhu, Hao; Afantitis, Antreas; Mouchlis, Varnavas D; Melagraki, Georgia; Rusyn, Ivan; Tropsha, Alexander Toxicology and applied pharmacology 23707773 2013 Oct 1
Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches. Medina-Franco, Jose L; Edwards, Bruce S; Pinilla, Clemencia; Appel, Jon R; Giulianotti, Marc A; Santos, Radleigh G; Yongye, Austin B; Sklar, Larry A; Houghten, Richard A Journal of chemical information and modeling 23705689 2013 Jun 24
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. Sweeney, Noreena L; Shadrick, William R; Mukherjee, Sourav; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David N The Journal of biological chemistry 23703611 2013 Jul 5
Multicomponent Assembly Processes for the Synthesis of Diverse Yohimbine and Corynanthe Alkaloid Analogues. Granger, Brett A; Wang, Zhiqian; Kaneda, Kyosuke; Fang, Zhenglai; Martin, Stephen F ACS combinatorial science 23697376 2013 Jun 4
Predicting drug-induced QT prolongation effects using multi-view learning. Zhang, Jintao; Huan, Jun IEEE transactions on nanobioscience 23694701 2013 Sep
Inside job: ligand-receptor pharmacology beneath the plasma membrane. Babcock, Joseph J; Li, Min Acta pharmacologica Sinica 23685953 2013 Jul
Synthesis of a Library of "Lead-Like" ýý-Lactams by a One Pot, Four-Component Reaction. Martin, Kevin S; Di Maso, Michael J; Fettinger, James C; Shaw, Jared Thomas ACS combinatorial science 23682712 2013 May 17
Development of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology. Watson, Venita Gresham; Drake, Katherine M; Peng, Yu; Napper, Andrew D Assay and drug development technologies 23679849 2013 May
Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. Lu, Jiuyi; Chen, Minyong; Ren, Xiu-Rong; Wang, Jiangbo; Lyerly, H Kim; Barak, Larry; Chen, Wei PloS one 23671675 2013
Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine. Blum, Gil; Islam, Kabirul; Luo, Minkui Current protocols in chemical biology 23667794 2013 Mar 1
Using Azido Analogue of S-Adenosyl-L-methionine for Bioorthogonal Profiling of Protein Methylation (BPPM). Blum, Gil; Islam, Kabirul; Luo, Minkui Current protocols in chemical biology 23667794 2013 Mar
Mechanism-based corrector combination restores ýýF508-CFTR folding and function. Okiyoneda, Tsukasa; Veit, Guido; Dekkers, Johanna F; Bagdany, Miklos; Soya, Naoto; Xu, Haijin; Roldan, Ariel; Verkman, Alan S; Kurth, Mark; Simon, Agnes; Hegedus, Tamas; Beekman, Jeffrey M; Lukacs, Gergely L Nature chemical biology 23666117 2013 Jul
New route to the ergoline skeleton via cyclization of 4-unsubstituted indoles. Burley, Scott D; Lam, Vicky V; Lakner, Frederick J; Bergdahl, B Mikael; Parker, Matthew A Organic letters 23659323 2013 Jun 7
A rapid membrane potential assay to monitor CFTR function and inhibition. Maitra, Rangan; Sivashanmugam, Perumal; Warner, Keith Journal of biomolecular screening 23653393 2013 Oct
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Xu, Wei; Chooi, Yit-Heng; Choi, Jin W; Li, Shuang; Vederas, John C; Da Silva, Nancy A; Tang, Yi Angewandte Chemie (International ed. in English) 23653178 2013 Jun 17
Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Zhou, Pingzheng; Yu, Haibo; Gu, Min; Nan, Fa-jun; Gao, Zhaobing; Li, Min Proceedings of the National Academy of Sciences of the United States of America 23650395 2013 May 21
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Yu, Haibo; Lin, Zhihong; Mattmann, Margrith E; Zou, Beiyan; Terrenoire, Cecile; Zhang, Hongkang; Wu, Meng; McManus, Owen B; Kass, Robert S; Lindsley, Craig W; Hopkins, Corey R; Li, Min Proceedings of the National Academy of Sciences of the United States of America 23650380 2013 May 21
Tricycles by a new ugi variation and pictet-spengler reaction in one pot. Sinha, Mantosh K; Khoury, Kareem; Herdtweck, Eberhardt; Domling, Alexander Chemistry (Weinheim an der Bergstrasse, Germany) 23649922 2013 Jun 17
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Coombs, Thomas C; Tanega, Cordelle; Shen, Min; Wang, Jenna L; Auld, Douglas S; Gerritz, Samuel W; Schoenen, Frank J; Thomas, Craig J; Aube, Jeffrey Bioorganic & medicinal chemistry letters 23642479 2013 Jun 15
High-Throughput Screen for Pharmacoperones of the Vasopressin Type 2 Receptor. Conn, P Michael; Smith, Emery; Hodder, Peter; Janovick, Jo Ann; Smithson, David C Journal of biomolecular screening 23640875 2013 May 2
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Engers, Darren W; Frist, Audrey Y; Lindsley, Craig W; Hong, Charles C; Hopkins, Corey R Bioorganic & medicinal chemistry letters 23639540 2013 Jun 1
An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. Leung, Chi K; Wang, Ying; Malany, Siobhan; Deonarine, Andrew; Nguyen, Kevin; Vasile, Stefan; Choe, Keith P PloS one 23637990 2013
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Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation. Panarese, Joseph D; Konkol, Leah C; Berry, Cynthia B; Bates, Brittney S; Aldrich, Leslie N; Lindsley, Craig W Tetrahedron letters 23606772 2013 May 1
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A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus. Chung, Dong-Hoon; Moore, Blake P; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I; Ananthan, Subramaniam; White, E Lucile; Jia, Fuli; Jonsson, Colleen B; Severson, William E Virology journal 23302182 2013
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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169. Tarr, James C; Turlington, Mark L; Reid, Paul R; Utley, Thomas J; Sheffler, Douglas J; Cho, Hyekyung P; Klar, Rebecca; Pancani, Tristano; Klein, Michael T; Bridges, Thomas M; Morrison, Ryan D; Blobaum, Anna L; Xiang, Zixui; Daniels, J Scott; Niswender, Co ACS chemical neuroscience 23173069 2012 Nov 21
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Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011). Deng, Xianming; Choi, Hwan Geun; Buhrlage, Sara J; Gray, Nathanael S Expert opinion on therapeutic patents 23126385 2012 Dec
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A survey of quantitative descriptions of molecular structure. Guha R, Willighagen E. Curr Top Med Chem 23110530 2012
Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection. Dorjsuren, Dorjbal; Kim, Daemyung; Vyjayanti, Vaddadi N; Maloney, David J; Jadhav, Ajit; Wilson 3rd, David M; Simeonov, Anton PloS one 23110144 2012
In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts. Guo, Jianxia; Clausen, Dana M; Beumer, Jan H; Parise, Robert A; Egorin, Merrill J; Bravo-Altamirano, Karla; Wipf, Peter; Sharlow, Elizabeth R; Wang, Qiming Jane; Eiseman, Julie L Cancer chemotherapy and pharmacology 23108699 2013 Feb
Biomimetic synthesis and biological evaluation of Aplidiopsamine A. Panarese, Joseph D; Lindsley, Craig W Organic letters 23106227 2012 Nov 16
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In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear Receptor NR2E3. Qin, Qiong; Knapinska, Anna; Dobri, Nicoleta; Madoux, Franck; Chase, Peter; Hodder, Peter; Petrukhin, Konstantin Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 23098562 2013 Apr
Compact quantum dots for single-molecule imaging. Smith, Andrew M; Nie, Shuming Journal of visualized experiments : JoVE 23093375 2012
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Discovery of small molecule fusion inhibitors targeting HIV-1 gp41. Zhou, Guangyan; Chu, Shidong Current pharmaceutical design 23092284 2013
Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches. Lynch, Caitlin; Pan, Yongmei; Li, Linhao; Ferguson, Stephen S; Xia, Menghang; Swaan, Peter W; Wang, Hongbing Pharmaceutical research 23090669 2013 Feb
Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapy. Williamson, Elizabeth A; Damiani, Leah; Leitao, Andrei; Hu, Chelin; Hathaway, Helen; Oprea, Tudor; Sklar, Larry; Shaheen, Montaser; Bauman, Julie; Wang, Wei; Nickoloff, Jac A; Lee, Suk-Hee; Hromas, Robert Cancer research 23090115 2012 Dec 1
Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. Kim, Yong Wook; Niphakis, Micah J; Georg, Gunda I The Journal of organic chemistry 23088256 2012 Nov 2
Phylogenetic approaches to natural product structure prediction. Ziemert, Nadine; Jensen, Paul R Methods in enzymology 23084938 2012
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Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design. Custodi, Chiara; Nuti, Roberto; Oprea, Tudor I; Macchiarulo, Antonio Journal of molecular graphics & modelling 23079642 2012 Sep
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7). Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Saldanha, S Adrian; Chase, Peter; Wang, Zhiwei; Civelli, Olivier; Hodder, Peter; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic & medicinal chemistry letters 23079522 2012 Dec 1
Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells. Le Marchand, Sylvain J; Piston, David W PloS one 23077547 2012
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase ýý. Yamanaka, Kinrin; Dorjsuren, Dorjbal; Eoff, Robert L; Egli, Martin; Maloney, David J; Jadhav, Ajit; Simeonov, Anton; Lloyd, R Stephen PloS one 23056190 2012
Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS. Environ Health Perspect 23052129 2013 Jan
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Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. Zheng, Weihong; Ibanez, Glorymar; Wu, Hong; Blum, Gil; Zeng, Hong; Dong, Aiping; Li, Fengling; Hajian, Taraneh; Allali-Hassani, Abdellah; Amaya, Maria F; Siarheyeva, Alena; Yu, Wenyu; Brown, Peter J; Schapira, Matthieu; Vedadi, Masoud; Min, Jinrong; Luo, Journal of the American Chemical Society 23043551 2012 Oct 31
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. Moore, Blake P; Chung, Dong Hoon; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Noah, James W; Sosa, Melinda I; Ananthan, Subramaniam; Tower, Nichole A; White, E Lucile; Jia, Fuli; Prisinzano, Thomas E; Aube, Jeffrey; Jonsson, C Journal of medicinal chemistry 23043370 2012 Oct 25
A torquoselective 6ýý electrocyclization approach to reserpine alkaloids. Barcan, Gregg A; Patel, Ashay; Houk, K N; Kwon, Ohyun Organic letters 23039026 2012 Nov 2
Assay Development Guidelines for Image-Based High Content Screening, High Content Analysis and High Content Imaging. Buchser W, Collins M, Garyantes T, Guha R, Haney S, Lemmon V, Li Z, Trask OJ. Assay Guidance Manual 23035272 2012 Oct 01
ýý-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. Xu, Miao; Liu, Ke; Swaroop, Manju; Porter, Forbes D; Sidhu, Rohini; Firnkes, Sally; Finkes, Sally; Ory, Daniel S; Marugan, Juan J; Xiao, Jingbo; Southall, Noel; Pavan, William J; Davidson, Cristin; Walkley, Steven U; Remaley, Alan T; Baxa, Ulrich; Sun, Wei; McKew, John C; Austin, Christopher P; Zheng, Wei The Journal of biological chemistry 23035117 2012 Nov 16
Identification and characterization of a compound that protects cardiac tissue from human Ether-a-go-go-related gene (hERG)-related drug-induced arrhythmias. Potet, Franck; Lorinc, Amanda N; Chaigne, Sebastien; Hopkins, Corey R; Venkataraman, Raghav; Stepanovic, Svetlana Z; Lewis, L Michelle; Days, Emily; Sidorov, Veniamin Y; Engers, Darren W; Zou, Beiyan; Afshartous, David; George Jr, Alfred L; Campbell, Cour The Journal of biological chemistry 23033485 2012 Nov 16
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. Haynes, Stuart W; Gao, Xue; Tang, Yi; Walsh, Christopher T Journal of the American Chemical Society 23030663 2012 Oct 24
High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding. Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A. PLoS One 23029124 2012
Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Carr, Gavin; Derbyshire, Emily R; Caldera, Eric; Currie, Cameron R; Clardy, Jon Journal of natural products 23025282 2012 Oct 26
MRI biosensor for protein kinase A encoded by a single synthetic gene. Airan, Raag D; Bar-Shir, Amnon; Liu, Guanshu; Pelled, Galit; McMahon, Michael T; van Zijl, Peter C M; Bulte, Jeff W M; Gilad, Assaf A Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 23023588 2012 Dec
Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. Preuss, Janina; Richardson, Adam D; Pinkerton, Anthony; Hedrick, Michael; Sergienko, Eduard; Rahlfs, Stefan; Becker, Katja; Bode, Lars Journal of biomolecular screening 23023104 2013 Mar
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A coincidence reporter-gene system for high-throughput screening. Cheng KC, Inglese J. Nat Methods 23018994 2012 Oct
Briareolate esters from the gorgonian Briareum asbestinum. Meginley, Rian J; Gupta, Prasoon; Schulz, Thomas C; McLean, Amanda B; Robins, Allan J; West, Lyndon M Marine drugs 23015768 2012 Aug
Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics. Kong, Koon Yin; Marcus, Adam I; Giannakakou, Paraskevi; Wang, May Dongmei International journal of computational biology and drug design 23013655 2012
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Nayar, Ribhu; Enos, Megan; Prince, Amanda; Shin, Hyunmu; Hemmers, Saskia; Jiang, Jian-kang; Klein, Ulf; Thomas, Craig J; Berg, Leslie J Proceedings of the National Academy of Sciences of the United States of America 23011795 2012 Oct 9
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Maloney, Patrick R; Khan, Pasha; Hedrick, Michael; Gosalia, Palak; Milewski, Monika; Li, Linda; Roth, Gregory P; Sergienko, Eduard; Suyama, Eigo; Sugarman, Eliot; Nguyen, Kevin; Mehta, Alka; Vasile, Stefan; Su, Ying; Stonich, Derek; Nguyen, Hung; Zeng, Fu Bioorganic & medicinal chemistry letters 23010269 2012 Nov 1
Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Knapp, John M; Zhu, Jie S; Tantillo, Dean J; Kurth, Mark J Angewandte Chemie (International ed. in English) 23001913 2012 Oct 15
Rapidly relocating molecules between organelles to manipulate small GTPase activity. Phua, Siew Cheng; Pohlmeyer, Christopher; Inoue, Takanari ACS chemical biology 22999378 2012 Dec 21
Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases. Smanski, Michael J; Peterson, Ryan M; Shen, Ben Methods in enzymology 22999174 2012
Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. J Transl Med 22999104 2012 Sep 21
Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. Cacho, Ralph A; Jiang, Wei; Chooi, Yit-Heng; Walsh, Christopher T; Tang, Yi Journal of the American Chemical Society 22998630 2012 Oct 10
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Huang, Fen; Zhang, Hongkang; Wu, Meng; Yang, Huanghe; Kudo, Makoto; Peters, Christian J; Woodruff, Prescott G; Solberg, Owen D; Donne, Matthew L; Huang, Xiaozhu; Sheppard, Dean; Fahy, John V; Wolters, Paul J; Hogan, Brigid L M; Finkbeiner, Walter E; Li, M Proceedings of the National Academy of Sciences of the United States of America 22988107 2012 Oct 2
Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds. Tomasini-Johansson, Bianca R; Johnson, Ian A; Hoffmann, F Michael; Mosher, Deane F Matrix biology : journal of the International Society for Matrix Biology 22986508 2012 Jul
Structure and biosynthesis of the antibiotic bottromycin D. Hou, Yanpeng; Tianero, Ma Diarey B; Kwan, Jason C; Wyche, Thomas P; Michel, Cole R; Ellis, Gregory A; Vazquez-Rivera, Emmanuel; Braun, Doug R; Rose, Warren E; Schmidt, Eric W; Bugni, Tim S Organic letters 22984777 2012 Oct 5
Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. Sirenko, Oksana; Crittenden, Carole; Callamaras, Nick; Hesley, Jayne; Chen, Yen-Wen; Funes, Carlos; Rusyn, Ivan; Anson, Blake; Cromwell, Evan F Journal of biomolecular screening 22972846 2013 Jan
Novel selective allosteric and bitopic ligands for the S1P(3) receptor. Jo, Euijung; Bhhatarai, Barun; Repetto, Emanuela; Guerrero, Miguel; Riley, Sean; Brown, Steven J; Kohno, Yasushi; Roberts, Edward; Schurer, Stephan C; Rosen, Hugh ACS chemical biology 22971058 2012 Dec 21
Efficient assembly of iminodicarboxamides by a "truly" four-component reaction. Khoury, Kareem; Sinha, Mantosh K; Nagashima, Tadamichi; Herdtweck, Eberhardt; Domling, Alexander Angewandte Chemie (International ed. in English) 22968839 2012 Oct 8
A dual-column solid phase extraction strategy for online collection and preparation of continuously flowing effluent streams for mass spectrometry. Enders, Jeffrey R; Marasco, Christina C; Wikswo, John P; McLean, John A Analytical chemistry 22967262 2012 Oct 16
New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. Yu, Zhiguo; Vodanovic-Jankovic, Sanja; Kron, Michael; Shen, Ben Organic letters 22967068 2012 Sep 21
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, A Nature structural & molecular biology 22961382 2012 Oct
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Khare, Tarang; Pai, Shraddha; Koncevicius, Karolis; Pal, Mrinal; Kriukiene, Edita; Liutkeviciute, Zita; Irimia, Manuel; Jia, Peixin; Ptak, Carolyn; Xia, Menghang; Tice, Raymond; Tochigi, Mamoru; Morera, Solange; Nazarians, Anaies; Belsham, Denise; Wong, Albert H C; Blencowe, Benjamin J; Wang, Sun Chong; Kapranov, Philipp; Kustra, Rafal; Labrie, Viviane; Klimasauskas, Saulius; Petronis, Arturas Nature structural & molecular biology 22961382 2012 Oct
Small molecule inhibitors of RORýýt: targeting Th17 cells and other applications. Huh, Jun R; Littman, Dan R European journal of immunology 22949321 2012 Sep
Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Pouliot, Lynn M; Chen, Yu-Chi; Bai, Jennifer; Guha, Rajarshi; Martin, Scott E; Gottesman, Michael M; Hall, Matthew D Cancer research 22942255 2012 Nov 15
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. Ndjomou, Jean; Kolli, Rajesh; Mukherjee, Sourav; Shadrick, William R; Hanson, Alicia M; Sweeney, Noreena L; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Schoenen, Frank J; Frick, David N Antiviral research 22940425 2012 Nov
Navigating the fungal polyketide chemical space: from genes to molecules. Chooi, Yit-Heng; Tang, Yi The Journal of organic chemistry 22938194 2012 Nov 16
Interspecies modulation of bacterial development through iron competition and siderophore piracy. Traxler, Matthew F; Seyedsayamdost, Mohammad R; Clardy, Jon; Kolter, Roberto Molecular microbiology 22931126 2012 Nov
Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination? Dai, Tianhong; Murray, Clinton K; Vrahas, Mark S; Baer, David G; Tegos, George P; Hamblin, Michael R The journal of trauma and acute care surgery 22929495 2012 Sep
Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Tebbets, Brad; Yu, Zhiguo; Stewart, Douglas; Zhao, Li-Xing; Jiang, Yi; Xu, Li-Hua; Andes, David; Shen, Ben; Klein, Bruce Medical mycology : official publication of the International Society for Human and Animal Mycology 22928922 2012 Aug 28
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A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells. Mathews, Lesley A; Keller, Jonathan M; Goodwin, Bonnie L; Guha, Rajarshi; Shinn, Paul; Mull, Rebecca; Thomas, Craig J; de Kluyver, Rachel L; Sayers, Thomas J; Ferrer, Marc Journal of biomolecular screening 22927676 2012 Oct
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Development of drugs for Epstein-Barr virus using high-throughput in silico virtual screening. Li, Ning; Thompson, Scott; Jiang, Hualiang; Lieberman, Paul M; Luo, Cheng Expert opinion on drug discovery 22822721 2010 Dec
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Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces paras Preuss, Janina; Maloney, Patrick; Peddibhotla, Satyamaheshwar; Hedrick, Michael P; Hershberger, Paul; Gosalia, Palak; Milewski, Monika; Li, Yujie Linda; Sugarman, Eliot; Hood, Becky; Suyama, Eigo; Nguyen, Kevin; Vasile, Stefan; Sergienko, Eduard; Mangravi Journal of medicinal chemistry 22813531 2012 Aug 23
Targeting iron assimilation to develop new antibacterials. Foley, Timothy L; Simeonov, Anton Expert opinion on drug discovery 22812521 2012 Sep
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O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase. Talukdar, Arindam; Zhao, Yujie; Lv, Wei; Bacher, Adelbert; Illarionov, Boris; Fischer, Markus; Cushman, Mark The Journal of organic chemistry 22780198 2012 Jul 20
Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles. Pathak, Tejas P; Osiak, Jaroslaw G; Vaden, Rachel M; Welm, Bryan E; Sigman, Matthew S Tetrahedron 22778488 2012 Jul 1
Highly efficient click labeling using 2-[ýýýýýF]fluoroethyl azide and synthesis of an ýýýýýFN-hydroxysuccinimide ester as conjugation agent. Zhou, Dong; Chu, Wenhua; Dence, Carmen S; Mach, Robert H; Welch, Michael J Nuclear medicine and biology 22770647 2012 Nov
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A FRET-based high throughput screening assay to identify inhibitors of anthrax protective antigen binding to capillary morphogenesis gene 2 protein. Rogers, Michael S; Cryan, Lorna M; Habeshian, Kaiane A; Bazinet, Lauren; Caldwell, Thomas P; Ackroyd, P Christine; Christensen, Kenneth A PloS one 22768167 2012
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Somvanshi, Vishal S; Sloup, Rudolph E; Crawford, Jason M; Martin, Alexander R; Heidt, Anthony J; Kim, Kwi-suk; Clardy, Jon; Ciche, Todd A Science (New York, N.Y.) 22767929 2012 Jul 6
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Mooreia alkaloidigena gen. nov., sp. nov. and Catalinimonas alkaloidigena gen. nov., sp. nov., alkaloid-producing marine bacteria in the proposed families Mooreiaceae fam. nov. and Catalimonadaceae fam. nov. in the phylum Bacteroidetes. Choi, Eun Ju; Beatty, Deanna S; Paul, Lauren A; Fenical, William; Jensen, Paul R International journal of systematic and evolutionary microbiology 22753528 2013 Apr
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Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012. Melancon, Bruce J; Utley, Thomas J; Sevel, Christian; Mattmann, Margrith E; Cheung, Yiu-Yin; Bridges, Thomas M; Morrison, Ryan D; Sheffler, Douglas J; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R Bioorganic & medicinal chemistry letters 22749871 2012 Aug 1
One-Pot, Two-Step Cascade Synthesis of Quinazolinotriazolobenzodiazepines. Guggenheim, Kathryn G; Toru, Hannah; Kurth, Mark J Organic letters 22746550 2012 Jun 29
General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity. Xu, Zhigang; Ayaz, Muhammad; Cappelli, Alexandra A; Hulme, Christopher ACS combinatorial science 22746181 2012 Aug 13
Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. Chang, Jerry C; Tomlinson, Ian D; Warnement, Michael R; Ustione, Alessandro; Carneiro, Ana M D; Piston, David W; Blakely, Randy D; Rosenthal, Sandra J The Journal of neuroscience : the official journal of the Society for Neuroscience 22745492 2012 Jun 27
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Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays. Mukherjee, Sourav; Hanson, Alicia M; Shadrick, William R; Ndjomou, Jean; Sweeney, Noreena L; Hernandez, John J; Bartczak, Diana; Li, Kelin; Frankowski, Kevin J; Heck, Julie A; Arnold, Leggy A; Schoenen, Frank J; Frick, David N Nucleic acids research 22740655 2012 Sep 1
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor. Salovich, James M; Vinson, Paige N; Sheffler, Douglas J; Lamsal, Atin; Utley, Thomas J; Blobaum, Anna L; Bridges, Thomas M; Le, Uyen; Jones, Carrie K; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, Co Bioorganic & medicinal chemistry letters 22738637 2012 Aug 1
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. Frankowski, Kevin J; Hedrick, Michael P; Gosalia, Palak; Li, Kelin; Shi, Shenghua; Whipple, David; Ghosh, Partha; Prisinzano, Thomas E; Schoenen, Frank J; Su, Ying; Vasile, S; Sergienko, Eduard; Gray, Wilson; Hariharan, Santosh; Milan, Loribelle; Heynen-G ACS chemical neuroscience 22737280 2012 Mar 21
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Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Delpire, Eric; Baranczak, Aleksandra; Waterson, Alex G; Kim, Kwangho; Kett, Nathan; Morrison, Ryan D; Daniels, J Scott; Weaver, C David; Lindsley, Craig W Bioorganic & medicinal chemistry letters 22727639 2012 Jul 15
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Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Smith, Susan M E; Min, Jaeki; Ganesh, Thota; Diebold, Becky; Kawahara, Tsukasa; Zhu, Yerun; McCoy, James; Sun, Aiming; Snyder, James P; Fu, Haian; Du, Yuhong; Lewis, Iestyn; Lambeth, J David Chemistry & biology 22726689 2012 Jun 22
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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. Digby, Gregory J; Noetzel, Meredith J; Bubser, Michael; Utley, Thomas J; Walker, Adam G; Byun, Nellie E; Lebois, Evan P; Xiang, Zixiu; Sheffler, Douglas J; Cho, Hyekyung P; Davis, Albert A; Nemirovsky, Natali E; Mennenga, Sarah E; Camp, Bryan W; Bimonte-N The Journal of neuroscience : the official journal of the Society for Neuroscience 22723693 2012 Jun 20
Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol. Fan, Yi Chiao; Kwon, Ohyun Organic letters 22721256 2012 Jul 6
A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Chen, Yun; Cao, Shugeng; Chai, Yunrong; Clardy, Jon; Kolter, Roberto; Guo, Jian-hua; Losick, Richard Molecular microbiology 22716461 2012 Aug
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Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. Rolfe, Alan; Ullah, Farman; Samarakoon, Thiwanka B; Kurtz, Ryan D; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R ACS combinatorial science 21902243 2011 Nov 14
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Antidiabetic actions of a non-agonist PPARýý ligand blocking Cdk5-mediated phosphorylation. Choi, Jang Hyun; Banks, Alexander S; Kamenecka, Theodore M; Busby, Scott A; Chalmers, Michael J; Kumar, Naresh; Kuruvilla, Dana S; Shin, Youseung; He, Yuanjun; Bruning, John B; Marciano, David P; Cameron, Michael D; Laznik, Dina; Jurczak, Michael J; Schur Nature 21892191 2011 Sep 22
Nonomuraea soli sp. nov., an actinomycete isolated from soil. Cao, Yan-Ru; Jin, Rong-Xian; Jiang, Yi; He, Wen-Xiang; Jiang, Cheng-Lin International journal of systematic and evolutionary microbiology 21890732 2012 Jul
Ligand-dependent perturbation of the conformational ensemble for the GPCR ýý2 adrenergic receptor revealed by HDX. West, Graham M; Chien, Ellen Y T; Katritch, Vsevolod; Gatchalian, Jovylyn; Chalmers, Michael J; Stevens, Raymond C; Griffin, Patrick R Structure (London, England : 1993) 21889352 2011 Oct 12
NRPS substrate promiscuity diversifies the xenematides. Crawford, Jason M; Portmann, Cyril; Kontnik, Renee; Walsh, Christopher T; Clardy, Jon Organic letters 21888371 2011 Oct 7
Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening. Bialkowska, Agnieszka B; Crisp, Melissa; Bannister, Thomas; He, Yuanjun; Chowdhury, Sarwat; Schurer, Stephan; Chase, Peter; Spicer, Timothy; Madoux, Franck; Tian, Chenlu; Hodder, Peter; Zaharevitz, Daniel; Yang, Vincent W Molecular cancer therapeutics 21885866 2011 Nov
The role of residue C410 on activation of the human vitamin D receptor by various ligands. Castillo, Hilda S; Ousley, Amanda M; Duraj-Thatte, Anna; Lindstrom, Kelli N; Patel, Dina D; Bommarius, Andreas S; Azizi, Bahareh The Journal of steroid biochemistry and molecular biology 21884792 2012 Jan
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Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Dobretsov, Sergey; Teplitski, Max; Bayer, Mirko; Gunasekera, Sarath; Proksch, Peter; Paul, Valerie J Biofouling 21882898 2011 Sep
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Evolution of secondary metabolite genes in three closely related marine actinomycete species. Freel, Kelle C; Nam, Sang-Jip; Fenical, William; Jensen, Paul R Applied and environmental microbiology 21873479 2011 Oct
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Zhao, Li-Xing; Huang, Sheng-Xiong; Tang, Shu-Kun; Jiang, Cheng-Lin; Duan, Yanwen; Beutler, John A; Henrich, Curtis J; McMahon, James B; Schmid, Tobias; Blees, Johanna S; Colburn, Nancy H; Rajski, Scott R; Shen, Ben Journal of natural products 21870828 2011 Sep 23
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an ýý-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. Li, Yanran; Chooi, Yit-Heng; Sheng, Yuewei; Valentine, Joan S; Tang, Yi Journal of the American Chemical Society 21866960 2011 Oct 5
Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery. Rolfe, Alan; Painter, Thomas O; Asad, Naeem; Hur, Moon Young; Jeon, Kyu Ok; Brzozowski, Marek; Klimberg, Sarra V; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Hanson, Paul R ACS combinatorial science 21866904 2011 Sep 12
Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Wang, Rui; Ibanez, Glorymar; Islam, Kabirul; Zheng, Weihong; Blum, Gil; Sengelaub, Caitlin; Luo, Minkui Molecular bioSystems 21866297 2011 Nov
Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. Fales, Andrew M; Yuan, Hsiangkuo; Vo-Dinh, Tuan Langmuir : the ACS journal of surfaces and colloids 21859159 2011 Oct 4
N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry. Wencewicz, Timothy A; Yang, Baiyuan; Rudloff, James R; Oliver, Allen G; Miller, Marvin J Journal of medicinal chemistry 21859126 2011 Oct 13
Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems. Henrikson, Jon C; Ellis, Trevor K; King, Jarrod B; Cichewicz, Robert H Journal of natural products 21854017 2011 Sep 23
Cross-pharmacology analysis of G protein-coupled receptors. Brianso, Ferran; Carrascosa, Maria C; Oprea, Tudor I; Mestres, Jordi Current topics in medicinal chemistry 21851335 2011
Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Montaser, Rana; Paul, Valerie J; Luesch, Hendrik Phytochemistry 21843895 2011 Nov
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. Martin, S E; Wu, Z-H; Gehlhaus, K; Jones, T L; Zhang, Y-W; Guha, R; Miyamoto, S; Pommier, Y; Caplen, N J Current cancer drug targets 21834757 2011 Oct
Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. Tran, Hoang T; Zhang, Shuxing Journal of chemical information and modeling 21834588 2011 Sep 26
Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds. Granger, Brett A; Kaneda, Kyosuke; Martin, Stephen F Organic letters 21834504 2011 Sep 2
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1ýý inhibitors. Huang, Wenwei; Huang, Ruili; Attene-Ramos, Matias S; Sakamuru, Srilatha; Englund, Erika E; Inglese, James; Austin, Christopher P; Xia, Menghang Bioorganic & medicinal chemistry letters 21831635 2011 Sep 15
Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Knapp, John M; Fettinger, James C; Kurth, Mark J Organic letters 21827181 2011 Sep 2
7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. Kiselev, Evgeny; DeGuire, Sean; Morrell, Andrew; Agama, Keli; Dexheimer, Thomas S; Pommier, Yves; Cushman, Mark Journal of medicinal chemistry 21823606 2011 Sep 8
Human pluripotent stem cells: the development of high-content screening strategies. Sherman, Sean P; Alva, Jackelyn A; Thakore-Shah, Kaushali; Pyle, April D Methods in molecular biology (Clifton, N.J.) 21822883 2011
Imaging mass spectrometry in microbiology. Watrous, Jeramie D; Dorrestein, Pieter C Nature reviews. Microbiology 21822293 2011 Sep
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BDDCS applied to over 900 drugs. Benet, Leslie Z; Broccatelli, Fabio; Oprea, Tudor I The AAPS journal 21818695 2011 Dec
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Yuan, Jing; Cheng, Ken Chih-Chien; Johnson, Ronald L; Huang, Ruili; Pattaradilokrat, Sittiporn; Liu, Anna; Guha, Rajarshi; Fidock, David A; Inglese, James; Wellems, Thomas E; Austin, Christopher P; Su, Xin-zhuan Science (New York, N.Y.) 21817045 2011 Aug 5
Metal-free chlorodeboronation of organotrifluoroborates. Molander, Gary A; Cavalcanti, Livia N The Journal of organic chemistry 21812468 2011 Sep 2
Phosphine-catalyzed annulations of azomethine imines: allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways. Na, Risong; Jing, Chengfeng; Xu, Qihai; Jiang, Hui; Wu, Xi; Shi, Jiayan; Zhong, Jiangchun; Wang, Min; Benitez, Diego; Tkatchouk, Ekaterina; Goddard, William A; Guo, Hongchao; Kwon, Ohyun Journal of the American Chemical Society 21812448 2011 Aug 31
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Youngsaye, Willmen; Vincent, Benjamin; Hartland, Cathy L; Morgan, Barbara J; Buhrlage, Sara J; Johnston, Stephen; Bittker, Joshua A; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L; Muno Bioorganic & medicinal chemistry letters 21802942 2011 Sep 15
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick; Gray, Nathanael S Chemistry & biology 21802008 2011 Jul 29
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Miduturu, Chandrasekhar V; Deng, Xianming; Kwiatkowski, Nicholas; Yang, Wannian; Brault, Laurent; Filippakopoulos, Panagis; Chung, Eunah; Yang, Qingkai; Schwaller, Juerg; Knapp, Stefan; King, Randall W; Lee, Jiing-Dwan; Herrgard, Sanna; Zarrinkar, Patrick Chemistry & biology 21802008 2011 Jul 29
Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Correa, Ricardo G; Khan, Pasha M; Askari, Nadav; Zhai, Dayong; Gerlic, Motti; Brown, Brock; Magnuson, Gavin; Spreafico, Roberto; Albani, Salvatore; Sergienko, Eduard; Diaz, Paul W; Roth, Gregory P; Reed, John C Chemistry & biology 21802003 2011 Jul 29
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. Miller, Melissa; Shi, Jie; Zhu, Yingmin; Kustov, Maksym; Tian, Jin-bin; Stevens, Amy; Wu, Meng; Xu, Jia; Long, Shunyou; Yang, Pu; Zholos, Alexander V; Salovich, James M; Weaver, C David; Hopkins, Corey R; Lindsley, Craig W; McManus, Owen; Li, Min; Zhu, Mi The Journal of biological chemistry 21795696 2011 Sep 23
SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1Pýýý) receptor. Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic & medicinal chemistry letters 21783362 2011 Sep 15
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. Dennis, Megan K; Field, Angela S; Burai, Ritwik; Ramesh, Chinnasamy; Petrie, Whitney K; Bologa, Cristian G; Oprea, Tudor I; Yamaguchi, Yuri; Hayashi, Shin-Ichi; Sklar, Larry A; Hathaway, Helen J; Arterburn, Jeffrey B; Prossnitz, Eric R The Journal of steroid biochemistry and molecular biology 21782022 2011 Nov
Zeocin for selection of bleMX6 resistance in fission yeast. Benko, Zsigmond; Zhao, Richard Y BioTechniques 21781055 2011 Jul
Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy. Lo, Kai-Yin; Sun, Yung-Shin; Landry, James P; Zhu, Xiangdong; Deng, Wenbin BioTechniques 21781038 2011 Jun
Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A. Leighty, Matthew W; Georg, Gunda I ACS medicinal chemistry letters 21779519 2011 Apr 14
A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis. Grimes, Kimberly D; Aldrich, Courtney C Analytical biochemistry 21771578 2011 Oct 15
A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support. Li, Yangmei; Giulianotti, Marc; Houghten, Richard A Tetrahedron letters 21765557 2010 Oct 27
Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds. Choi, Jonghoon; Kim, Kyobum; Kim, Taeho; Liu, Guanshu; Bar-Shir, Amnon; Hyeon, Taeghwan; McMahon, Michael T; Bulte, Jeff W M; Fisher, John P; Gilad, Assaf A Journal of controlled release : official journal of the Controlled Release Society 21763735 2011 Dec 10
Sequencing cyclic peptides by multistage mass spectrometry. Mohimani, Hosein; Yang, Yu-Liang; Liu, Wei-Ting; Hsieh, Pei-Wen; Dorrestein, Pieter C; Pevzner, Pavel A Proteomics 21751357 2011 Sep
Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Brown, Lauren E; Dai, Peng; Porco Jr, John A; Schaus, Scott E Organic letters 21749159 2011 Aug 19
Bioactive diterpenoid containing a reversible "spring-loaded" (E,Z)-dieneone Michael acceptor. Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C; Sherrer, Eric S; McLean, Amanda B; Robins, Allan J; West, Lyndon M Organic letters 21749084 2011 Aug 5
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches. Ekland, Eric H; Schneider, Jessica; Fidock, David A FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21746861 2011 Oct
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, Journal of medicinal chemistry 21739938 2011 Aug 11
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. Kenyon, Victor; Rai, Ganesha; Jadhav, Ajit; Schultz, Lena; Armstrong, Michelle; Jameson 2nd, J Brian; Perry, Steven; Joshi, Netra; Bougie, James M; Leister, William; Taylor-Fishwick, David A; Nadler, Jerry L; Holinstat, Michael; Simeonov, Anton; Maloney, David J; Holman, Theodore R Journal of medicinal chemistry 21739938 2011 Aug 11
Phosphine-catalyzed [4+2] annulations of 2-alkylallenoates and olefins: synthesis of multisubstituted cyclohexenes. Tran, Yang S; Martin, Tioga J; Kwon, Ohyun Chemistry, an Asian journal 21739609 2011 Aug 1
First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp. Wyche, Thomas P; Hou, Yanpeng; Braun, Doug; Cohen, Hannah C; Xiong, May P; Bugni, Tim S The Journal of organic chemistry 21736356 2011 Aug 19
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD. J Biol Chem 21733839 2011 Sep 9
Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Prigozhina, Natalie L; Heisel, Andrew; Wei, Ke; Noberini, Roberta; Hunter, Edward A; Calzolari, Diego; Seldeen, Jordan R; Pasquale, Elena B; Ruiz-Lozano, Pilar; Mercola, Mark; Price, Jeffrey H Biology of the cell / under the auspices of the European Cell Biology Organization 21732911 2011 Oct 1
Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol. Asad, Naeem; Hanson, Paul R; Long, Toby R; Rayabarapu, Dinesh K; Rolfe, Alan Chemical communications (Cambridge, England) 21727956 2011 Sep 7
Receptor-based pharmacophore and pharmacophore key descriptors for virtual screening and QSAR modeling. Dong, Xialan; Ebalunode, Jerry O; Yang, Sheng-Yong; Zheng, Weifan Current computer-aided drug design 21726192 2011 Sep 1
Animal models of idiosyncratic drug-induced liver injury--current status. Roth, Robert A; Ganey, Patricia E Critical reviews in toxicology 21726137 2011 Oct
Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. Edlund, Anna; Loesgen, Sandra; Fenical, William; Jensen, Paul R Applied and environmental microbiology 21724881 2011 Sep
Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori. Fei, Y Y; Schmidt, A; Bylund, G; Johansson, D X; Henriksson, S; Lebrilla, C; Solnick, J V; Boren, T; Zhu, X D Analytical chemistry 21721569 2011 Aug 15
Synthesis and structure-activity evaluation of isatin-ýý-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein. Hall, Matthew D; Brimacombe, Kyle R; Varonka, Matthew S; Pluchino, Kristen M; Monda, Julie K; Li, Jiayang; Walsh, Martin J; Boxer, Matthew B; Warren, Timothy H; Fales, Henry M; Gottesman, Michael M Journal of medicinal chemistry 21721528 2011 Aug 25
Parallel synthesis of a desketoraloxifene analogue library via iodocyclization/palladium-catalyzed coupling. Cho, Chul-Hee; Jung, Dai-Il; Neuenswander, Benjamin; Larock, Richard C ACS combinatorial science 21721520 2011 Sep 12
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples. Simons, Peter C; Young, Susan M; Carter, Mark B; Waller, Anna; Zhai, Dayong; Reed, John C; Edwards, Bruce S; Sklar, Larry A Nature protocols 21720309 2011 Jul
Microbial competition between Bacillus subtilis and Staphylococcus aureus monitored by imaging mass spectrometry. Gonzalez, David J; Haste, Nina M; Hollands, Andrew; Fleming, Tinya C; Hamby, Matthew; Pogliano, Kit; Nizet, Victor; Dorrestein, Pieter C Microbiology (Reading, England) 21719540 2011 Sep
Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Antczak, Christophe; Shum, David; Bassit, Bhramdeo; Frattini, Mark G; Li, Yueming; de Stanchina, Elisa; Scheinberg, David A; Djaballah, Hakim Bioorganic & medicinal chemistry letters 21719286 2011 Aug 1
Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Walsh, Kevin B; Teijaro, John R; Wilker, Peter R; Jatzek, Anna; Fremgen, Daniel M; Das, Subash C; Watanabe, Tokiko; Hatta, Masato; Shinya, Kyoko; Suresh, Marulasiddappa; Kawaoka, Yoshihiro; Rosen, Hugh; Oldstone, Michael B A Proceedings of the National Academy of Sciences of the United States of America 21715659 2011 Jul 19
QSAR analysis of the toxicity of nitroaromatics in Tetrahymena pyriformis: structural factors and possible modes of action. Artemenko, A G; Muratov, E N; Kuz'min, V E; Muratov, N N; Varlamova, E V; Kuz'mina, A V; Gorb, L G; Golius, A; Hill, F C; Leszczynski, J; Tropsha, A SAR and QSAR in environmental research 21714735 2011 Jul-Sep
Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. Peterson, Katherine E; Cinelli, Maris A; Morrell, Andrew E; Mehta, Akhil; Dexheimer, Thomas S; Agama, Keli; Antony, Smitha; Pommier, Yves; Cushman, Mark Journal of medicinal chemistry 21710981 2011 Jul 28
A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae. Rasmussen, Lynn; White, E Lucile; Pathak, Ashish; Ayala, Julio C; Wang, Hongxia; Wu, Jian-He; Benitez, Jorge A; Silva, Anisia J Antimicrobial agents and chemotherapy 21709090 2011 Sep
Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry. Kliman, Michal; May, Jody C; McLean, John A Biochimica et biophysica acta 21708282 2011 Nov
Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp. Meickle, Theresa; Gunasekera, Sarath P; Liu, Yanxia; Luesch, Hendrik; Paul, Valerie J Bioorganic & medicinal chemistry 21705224 2011 Nov 15
In situ kinase profiling reveals functionally relevant properties of native kinases. Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Wu, Jiangyue; Brown, Heidi; Zhou, David; Zhang, Jianming; Jagannathan, Subadhra; Aban, Arwin; Okerberg, Eric; Herring, Chris; Nordin, Brian; Weissig, Helge; Yang, Qingkai; Lee, Jiing-Dwan; Gray, Nathanael S; Koz Chemistry & biology 21700206 2011 Jun 24
Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. Seyedsayamdost, Mohammad R; Traxler, Matthew F; Zheng, Shao-Liang; Kolter, Roberto; Clardy, Jon Journal of the American Chemical Society 21699219 2011 Aug 3
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Lone, Anna Mari; Bachovchin, Daniel A; Westwood, David B; Speers, Anna E; Spicer, Timothy P; Fernandez-Vega, Virneliz; Chase, Peter; Hodder, Peter S; Rosen, Hugh; Cravatt, Benjamin F; Saghatelian, Alan Journal of the American Chemical Society 21692504 2011 Aug 3
Enhancing the rate of scaffold discovery with diversity-oriented prioritization. Swamidass, S Joshua; Calhoun, Bradley T; Bittker, Joshua A; Bodycombe, Nicole E; Clemons, Paul A Bioinformatics (Oxford, England) 21685049 2011 Aug 15
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. Gonzalez-Lopez, Marcos; Welsh, Kate; Finlay, Darren; Ardecky, Robert J; Ganji, Santhi Reddy; Su, Ying; Yuan, Hongbin; Teriete, Peter; Mace, Peter D; Riedl, Stefan J; Vuori, Kristiina; Reed, John C; Cosford, Nicholas D P Bioorganic & medicinal chemistry letters 21680182 2011 Jul 15
Up-regulation of A-type potassium currents protects neurons against cerebral ischemia. Deng, Ping; Pang, Zhi-Ping; Lei, Zhigang; Shikano, Sojin; Xiong, Qiaojie; Harvey, Brandon K; London, Barry; Wang, Yun; Li, Min; Xu, Zao C Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 21673715 2011 Sep
Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Espinoza, Stefano; Salahpour, Ali; Masri, Bernard; Sotnikova, Tatyana D; Messa, Mirko; Barak, Larry S; Caron, Marc G; Gainetdinov, Raul R Molecular pharmacology 21670104 2011 Sep
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination. Dever, Seth M; Golding, Sarah E; Rosenberg, Elizabeth; Adams, Bret R; Idowu, Michael O; Quillin, John M; Valerie, Nicholas; Xu, Bo; Povirk, Lawrence F; Valerie, Kristoffer Aging 21666281 2011 May
Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones. Kantevari, Srinivas; Yempala, Thirumal; Yogeeswari, Perumal; Sriram, Dharmarajan; Sridhar, Balasubramanian Bioorganic & medicinal chemistry letters 21665469 2011 Jul 15
Reconstituting the key steps of the DNA double-strand break repair in vitro. Rossi, Matthew J; Bugreev, Dmitry V; Mazina, Olga M; Mazin, Alexander V Methods in molecular biology (Clifton, N.J.) 21660707 2011
Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities. Agola, J O; Jim, P A; Ward, H H; Basuray, S; Wandinger-Ness, A Clinical genetics 21651512 2011 Oct
Synthesis of spiro-fused pyrazolidoylisoxazolines. Guggenheim, Kathryn G; Butler, Jeffrey D; Painter, Phillip P; Lorsbach, Beth A; Tantillo, Dean J; Kurth, Mark J The Journal of organic chemistry 21650164 2011 Jul 15
Design, synthesis, and diversification of 3,5-substituted enone library. Khalaf, Juhienah; Estrella-Jimenez, Maria E; Shashack, Matthew J; Phatak, Sharangdhar S; Zhang, Shuxing; Gilbertson, Scott R ACS combinatorial science 21648460 2011 Jul 11
2D NMR-spectroscopic screening reveals polyketides in ladybugs. Deyrup, Stephen T; Eckman, Laura E; McCarthy, Patrick H; Smedley, Scott R; Meinwald, Jerrold; Schroeder, Frank C Proceedings of the National Academy of Sciences of the United States of America 21646540 2011 Jun 14
Two High Throughput Screen Assays for Measurement of TNF-ýý in THP-1 Cells. Leister, Kristin P; Huang, Ruili; Goodwin, Bonnie L; Chen, Andrew; Austin, Christopher P; Xia, Menghang Current chemical genomics 21643507 2011
Exploratory analysis of kinetic solubility measurements of a small molecule library. Guha, Rajarshi; Dexheimer, Thomas S; Kestranek, Aimee N; Jadhav, Ajit; Chervenak, Andrew M; Ford, Michael G; Simeonov, Anton; Roth, Gregory P; Thomas, Craig J Bioorganic & medicinal chemistry 21640593 2011 Jul 1
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. Bachovchin, Daniel A; Zuhl, Andrea M; Speers, Anna E; Wolfe, Monique R; Weerapana, Eranthie; Brown, Steven J; Rosen, Hugh; Cravatt, Benjamin F Journal of medicinal chemistry 21639134 2011 Jul 28
RGD-conjugated human ferritin nanoparticles for imaging vascular inflammation and angiogenesis in experimental carotid and aortic disease. Kitagawa, Toshiro; Kosuge, Hisanori; Uchida, Masaki; Dua, Monica M; Iida, Yasunori; Dalman, Ronald L; Douglas, Trevor; McConnell, Michael V Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 21638084 2012 Jun
Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Sooryakumar, Dhriti; Dexheimer, Thomas S; Teicher, Beverly A; Pommier, Yves Molecular cancer therapeutics 21636699 2011 Aug
The JAK2/STAT3 signaling pathway is required for growth of CD44ýýýCD24ýýý stem cell-like breast cancer cells in human tumors. Marotta, Lauren L C; Almendro, Vanessa; Marusyk, Andriy; Shipitsin, Michail; Schemme, Janina; Walker, Sarah R; Bloushtain-Qimron, Noga; Kim, Jessica J; Choudhury, Sibgat A; Maruyama, Reo; Wu, Zhenhua; Gonen, Mithat; Mulvey, Laura A; Bessarabova, Marina O; The Journal of clinical investigation 21633165 2011 Jul
Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Shukla, Suneet; Skoumbourdis, Amanda P; Walsh, Martin J; Hartz, Anika M S; Fung, King Leung; Wu, Chung-Pu; Gottesman, Michael M; Bauer, Bjorn; Thomas, Craig J; Ambudkar, Suresh V Molecular pharmaceutics 21630681 2011 Aug 1
Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Wythe, Joshua D; Jurynec, Michael J; Urness, Lisa D; Jones, Christopher A; Sabeh, M Khaled; Werdich, Andreas A; Sato, Mariko; Yost, H Joseph; Grunwald, David J; Macrae, Calum A; Li, Dean Y Disease models & mechanisms 21628396 2011 Sep-Oct
Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization. Pokorski, Jonathan K; Breitenkamp, Kurt; Liepold, Lars O; Qazi, Shefah; Finn, M G Journal of the American Chemical Society 21627118 2011 Jun 22
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Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines. Markina, Nataliya A; Mancuso, Raffaella; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C ACS combinatorial science 21410207 2011 May 9
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A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions. Du, Yuhong; Nikolovska-Coleska, Zaneta; Qui, Min; Li, Lian; Lewis, Iestyn; Dingledine, Raymond; Stuckey, Jeanne A; Krajewski, Krzysztof; Roller, Peter P; Wang, Shaomeng; Fu, Haian Assay and drug development technologies 21395401 2011 Aug
One-pot synthesis of 2-amino-indole-3-carboxamide and analogous. Wang, Kan; Herdtweck, Eberhardt; Domling, Alexander ACS combinatorial science 21395342 2011 Mar 14
Deep UV nano-microstructuring of substrates for surface plasmon resonance imaging. Dhawan, A; Duval, A; Nakkach, M; Barbillon, G; Moreau, J; Canva, M; Vo-Dinh, T Nanotechnology 21393822 2011 Apr 22
Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. LaFleur, Michael D; Lucumi, Edinson; Napper, Andrew D; Diamond, Scott L; Lewis, Kim The Journal of antimicrobial chemotherapy 21393183 2011 Apr
Protein cage nanoparticles bearing the LyP-1 peptide for enhanced imaging of macrophage-rich vascular lesions. Uchida, Masaki; Kosuge, Hisanori; Terashima, Masahiro; Willits, Deborah A; Liepold, Lars O; Young, Mark J; McConnell, Michael V; Douglas, Trevor ACS nano 21391720 2011 Apr 26
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AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Pan, Jen Q; Lewis, Michael C; Ketterman, Josh K; Clore, Elizabeth L; Riley, Misha; Richards, Keenan R; Berry-Scott, Erin; Liu, Xiulin; Wagner, Florence F; Holson, Edward B; Neve, Rachael L; Biechele, Travis L; Moon, Randall T; Scolnick, Edward M; Petryshe Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 21389981 2011 Jun
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A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines. Qiao, Kangjian; Zhou, Hui; Xu, Wei; Zhang, Wenjun; Garg, Neil; Tang, Yi Organic letters 21384820 2011 Apr 1
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Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors. Busby, Scott A; Kumar, Naresh; Kuruvilla, Dana S; Istrate, Monica A; Conkright, Juliana J; Wang, Yongjun; Kamenecka, Theodore M; Cameron, Michael D; Roush, William R; Burris, Thomas P; Griffin, Patrick R ACS chemical biology 21381756 2011 Jun 17
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Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. Chou, Tsui-Fen; Deshaies, Raymond J The Journal of biological chemistry 21343295 2011 May 13
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Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. Gunasekera, Sarath P; Owle, Chivas S; Montaser, Rana; Luesch, Hendrik; Paul, Valerie J Journal of natural products 21341718 2011 Apr 25
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Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluýýý. Cheung, Yiu-Yin; Zamorano, Rocio; Blobaum, Anna L; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R ACS combinatorial science 21338051 2011 Mar 14
A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. Li, Hui-Fang; Keeton, Adam; Vitolo, Michele; Maddox, Clinton; Rasmussen, Lynn; Hobrath, Judith; White, E Lucille; Park, Ben Ho; Piazza, Gary A; Kim, Jung-Sik; Waldman, Todd Journal of biomolecular screening 21335596 2011 Apr
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Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Chalmers, Michael J; Busby, Scott A; Pascal, Bruce D; West, Graham M; Griffin, Patrick R Expert review of proteomics 21329427 2011 Feb
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. Liu, Qingsong; Wang, Jinhua; Kang, Seong A; Thoreen, Carson C; Hur, Wooyoung; Ahmed, Tausif; Sabatini, David M; Gray, Nathanael S Journal of medicinal chemistry 21322566 2011 Mar 10
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Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. Hwang, Jong Yeon; Huang, Wenwei; Arnold, Leggy A; Huang, Ruili; Attia, Ramy R; Connelly, Michele; Wichterman, Jennifer; Zhu, Fangyi; Augustinaite, Indre; Austin, Christopher P; Inglese, James; Johnson, Ronald L; Guy, R Kiplin The Journal of biological chemistry 21321127 2011 Apr 8
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A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. Abi-Ghanem, Daad; Lai, Xinzhong; Berghman, Luc R; Horvat, Darijana; Li, Jing; Romo, Daniel; Uddin, Mohammad N; Kamano, Yoshiaki; Nogawa, Toshihiko; Xu, Jun-Ping; Pettit, George R; Puschett, Jules B Journal of immunoassay & immunochemistry 21253968 2011
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A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. Neumann, Susanne; Eliseeva, Elena; McCoy, Joshua G; Napolitano, Giorgio; Giuliani, Cesidio; Monaco, Fabrizio; Huang, Wenwei; Gershengorn, Marvin C The Journal of clinical endocrinology and metabolism 21123444 2011 Feb
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Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop. Critton, David A; Tautz, Lutz; Page, Rebecca Journal of molecular biology 21094165 2011 Jan 21
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Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. Passer, Brent J; Cheema, Tooba; Zhou, Bingsen; Wakimoto, Hiroaki; Zaupa, Cecile; Razmjoo, Mani; Sarte, Jason; Wu, Shulin; Wu, Chin-lee; Noah, James W; Li, Qianjun; Buolamwini, John K; Yen, Yun; Rabkin, Samuel D; Martuza, Robert L Cancer research 20424118 2010 May 15
A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells. Sylvester, Juliesta E; Kron, Stephen J Molecular cancer therapeutics 20423990 2010 May
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A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding. Gunther, Jillian R; Du, Yuhong; Rhoden, Eric; Lewis, Iestyn; Revennaugh, Brian; Moore, Terry W; Kim, Sung Hoon; Dingledine, Raymond; Fu, Haian; Katzenellenbogen, John A Journal of biomolecular screening 19196699 2009 Feb
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Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. Carpenter, Richard D; Andrei, Mirela; Aina, Olulanu H; Lau, Edmond Y; Lightstone, Felice C; Liu, Ruiwu; Lam, Kit S; Kurth, Mark J Journal of medicinal chemistry 19072684 2009 Jan 8
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A novel synthetic route to 3-sulfenyl- and 3-selenylindoles by n-Bu4NI-induced electrophilic cyclization. Chen, Yu; Cho, Chul-Hee; Larock, Richard C Organic letters 19046068 2009 Jan 1
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Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Sidique, Shyama; Ardecky, Robert; Su, Ying; Narisawa, Sonoko; Brown, Brock; Millan, Jose Luis; Sergienko, Eduard; Cosford, Nicholas D P Bioorganic & medicinal chemistry letters 19038545 2009 Jan 1
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The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Sahin, Selma; Benet, Leslie Z Pharmaceutical research 19015955 2008 Dec
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Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. Gonzalez-Cestari, Tatiana F; Henderson, Brandon J; Pavlovicz, Ryan E; McKay, Susan B; El-Hajj, Raed A; Pulipaka, Aravinda B; Orac, Crina M; Reed, Damon D; Boyd, R Thomas; Zhu, Michael X; Li, Chenglong; Bergmeier, Stephen C; McKay, Dennis B The Journal of pharmacology and experimental therapeutics 18984653 2009 Feb
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Surface-grafting of phosphates onto a polymer for potential biomimetic functionalization of biomaterials. Ko, Young Gun; Ma, Peter X Journal of colloid and interface science 18977490 2009 Feb 1
Resonance frequencies of lipid-shelled microbubbles in the regime of nonlinear oscillations. Doinikov, Alexander A; Haac, Jillian F; Dayton, Paul A Ultrasonics 18977009 2009 Feb
A human ferritin iron oxide nano-composite magnetic resonance contrast agent. Uchida, Masaki; Terashima, Masahiro; Cunningham, Charles H; Suzuki, Yoriyasu; Willits, Deborah A; Willis, Ann F; Yang, Philip C; Tsao, Philip S; McConnell, Michael V; Young, Mark J; Douglas, Trevor Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 18956458 2008 Nov
Isolation and structure determination of a proteasome inhibitory metabolite from a culture of Scytonema hofmanni. Shim, Sang Hee; Chlipala, George; Orjala, Jimmy Journal of microbiology and biotechnology 18955814 2008 Oct
Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes. Torreira, Eva; Jha, Sudhakar; Lopez-Blanco, Jose R; Arias-Palomo, Ernesto; Chacon, Pablo; Canas, Cristina; Ayora, Sylvia; Dutta, Anindya; Llorca, Oscar Structure (London, England : 1993) 18940606 2008 Oct 8
Parallel synthesis of a multi-substituted benzo[b]furan library. Cho, Chul-Hee; Neuenswander, Benjamin; Lushington, Gerald H; Larock, Richard C Journal of combinatorial chemistry 18937516 2008 Nov-Dec
Surface-enhanced Raman nanoparticle beacons based on bioconjugated gold nanocrystals and long range plasmonic coupling. Qian, Ximei; Zhou, Xi; Nie, Shuming Journal of the American Chemical Society 18937463 2008 Nov 12
Remarkably efficient synthesis of 2H-indazole 1-oxides and 2H-indazoles via tandem carbon-carbon followed by nitrogen-nitrogen bond formation. Bouillon, Isabelle; Zajicek, Jaroslav; Pudelova, Nadyyzda; Krchnak, Viktor The Journal of organic chemistry 18937414 2008 Nov 21
A new synthesis of symmetric boraindacene (BODIPY) dyes. Wu, Liangxing; Burgess, Kevin Chemical communications (Cambridge, England) 18931743 2008 Oct 28
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury. Shaw, Patrick J; Ditewig, Amy C; Waring, Jeffrey F; Liguori, Michael J; Blomme, Eric A; Ganey, Patricia E; Roth, Robert A Toxicological sciences : an official journal of the Society of Toxicology 18930950 2009 Jan
Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7). Iscru, Emilia; Serinagaoglu, Yelda; Schilling, Karl; Tian, Jinbin; Bowers-Kidder, Stephanie L; Zhang, Rui; Morgan, James I; DeVries, A Courtney; Nelson, Randy J; Zhu, Michael X; Oberdick, John Molecular and cellular neurosciences 18930827 2009 Jan
Synthesis and spectroscopic properties of rosamines with cyclic amine substituents. Wu, Liangxing; Burgess, Kevin