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Common Fund Programs


Common Fund Programs
New Tools and Methods
Databases and Libraries
High Throughput Analyses
Population Science
CURRENT PROGRAMS              
4D Nucleome
Big Data to Knowledge
Bioinformatics and Computational Biology
Enhancing the Diversity of the NIH-Funded Workforce
Extracellular RNA Communication
Gabriella Miller Kids First Pediatric Research Program
Genotype-Tissue Expression (GTEx)
Global Health
Gulf Oil Spill
HCS Research Collaboratory
Health Economics
HIGH-RISK RESEARCH:              
Human Microbiome Project (HMP)
Illuminating the Druggable Genome
Knock out Mouse Phenotyping (KOMP2)
Library of Integrated Network-Based Cellular Signatures (LINCS)
Molecular Transducers of Physical Activity in Humans
NIH Center for Regenerative Medicine (NIH CRM)
Protein Capture Reagents
Regulatory Science
Science of Behavior Change
Single Cell Analysis
Stimulating Peripheral Activity to Relieve Conditions (SPARC)
Strengthening the Biomedical Research Workforce
Undiagnosed Diseases Network
FORMER PROGRAMS              
Bridging Interventional Development
Gaps (BrIDGs)
Building Blocks, Biological Pathways and Networks
Clinical Research Policy Analysis and Coordination (CRPac)
Clinical and Translational Science Awards (CTSAs)
Interdisciplinary Research (IR)
National Electronics Clinical Trials and Research (NECTAR)
Molecular Libraries and Imaging
The Molecular Libraries Probe Production Centers Network (MLPCN) of the Molecular Libraries and Imaging program is a nationwide consortium of small molecule screening centers that are producing innovative chemical tools for use in biological research. These chemical tools, or probes, can be used to explore biological function of target proteins and as launching points for lead optimization discovery. A list of probes can be found at: http://mli.nih.gov/mli/.
The program is also enhancing the discovery and availability of small molecules for imaging of molecules or molecular events in biological systems that span the scale from single cells to whole organisms. The Imaging Probe Development Center (IPDC) offers the production of known imaging probes for the research community in cases where there is no viable commercial supplier, and generates novel imaging probes for biomedical research and clinical applications.
The Molecular Libraries Probe Production Centers Network (MLPCN) has established a collection of thousands of chemically diverse small molecules, some of which have known biological activities and others of which have the potential to modulate novel biological functions. All of the screening results from the MLPCN are placed into a public database called PubChem, a comprehensive database of chemical structures and their biological activities developed by the National Center for Biotechnology Information at NIH. PubChem includes information about chemical compounds that is made available to all researchers, in both public and private sectors, for their use in studying biology and disease. PubChem houses both compound information from the scientific literature as well as screening and probe data from the MLPCN. Another database, the Molecular Imaging and Contrast Agent Database (MICAD) is a source of information regarding molecular imaging and contrast agents that have in vivo data (animal or human) published in peer-reviewed scientific journals.
NIH Medical Research Scholars Program
PROMIS: Patient-Reported Outcomes Measurement Information System
Structural Biology




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