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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Authors Journal PubMedID Publication Date
Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2. Yin, Terry C; Mittal, Ayushi; Buscaglia, Paul; Li, Wenxian; Sebag, Julien A The Journal of biological chemistry 36539034 2023 Jan
The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse. Danielli, Sara; Ma, Zhongming; Pantazi, Eirini; Kumar, Amrendra; Demarco, Benjamin; Fischer, Fabian A; Paudel, Usha; Weissenrieder, Jillian; Lee, Robert J; Joyce, Sebastian; Foskett, J Kevin; Bezbradica, Jelena S The EMBO journal 36861806 2023 Apr 03
Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome. Xing, Zhuo; Li, Yichen; Cortes-Gomez, Eduardo; Jiang, Xiaoling; Gao, Shuang; Pao, Annie; Shan, Jidong; Song, Yinghui; Perez, Amanda; Yu, Tao; Highsmith, Max R; Boadu, Frimpong; Conroy, Jeffrey M; Singh, Prashant K; Bakin, Andrei V; Cheng, Jianlin; Duan, Zhijun; Wang, Jianmin; Liu, Song; Tycko, Benjamin; Yu, Y Eugene Human molecular genetics 37014740 2023 Jun 19
Beyond PI3Ks: targeting phosphoinositide kinases in disease. Burke, John E; Triscott, Joanna; Emerling, Brooke M; Hammond, Gerald R V Nature reviews. Drug discovery 36376561 2023 May
Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels. Lee, Sun-Joo; Maeda, Shoji; Gao, Jian; Nichols, Colin G Function (Oxford, England) 37168492 2023
Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury. Kim, Ji Young; Silvaroli, Josie A; Martinez, Gabriela Vasquez; Bisunke, Bijay; Luna Ramirez, Alanys V; Jayne, Laura A; Feng, Mei Ji He Ho; Girotra, Bhavya; Acosta Martinez, Shirely M; Vermillion, Corynne R; Karel, Isaac Z; Ferrell, Nicholas; Weisleder, Noah; Chung, Sangwoon; Christman, John W; Brooks, Craig R; Madhavan, Sethu M; Hoyt, Kari R; Cianciolo, Rachel E; Satoskar, Anjali A; Zepeda-Orozco, Diana; Sullivan, Jennifer C; Davidson, Alan J; Bajwa, Amandeep; Pabla, Navjot Singh Kidney international 36921719 2023 Jun
Single-molecule imaging in the primary cilium. Weiss, Lucien E; Love, Julia F; Yoon, Joshua; Comerci, Colin J; Milenkovic, Ljiljana; Kanie, Tomoharu; Jackson, Peter K; Stearns, Tim; Gustavsson, Anna-Karin Methods in cell biology 37164543 2023
PrismEXP: gene annotation prediction from stratified gene-gene co-expression matrices. Lachmann, Alexander; Rizzo, Kaeli A; Bartal, Alon; Jeon, Minji; Clarke, Daniel J B; Ma'ayan, Avi PeerJ 36874981 2023
Enrichr-KG: bridging enrichment analysis across multiple libraries. Evangelista, John Erol; Xie, Zhuorui; Marino, Giacomo B; Nguyen, Nhi; Clarke, Daniel J B; Ma'ayan, Avi Nucleic acids research 37166973 2023 Jul 05
VIGET: A web portal for study of vaccine-induced host responses based on Reactome pathways and ImmPort data. Brunson, Timothy; Sanati, Nasim; Huffman, Anthony; Masci, Anna Maria; Zheng, Jie; Cooke, Michael F; Conley, Patrick; He, Yongqun; Wu, Guanming Frontiers in immunology 37180100 2023
Illuminating Dark Proteins using Reactome Pathways. Brunson, Timothy; Sanati, Nasim; Matthews, Lisa; Haw, Robin; Beavers, Deidre; Shorser, Solomon; Sevilla, Cristoffer; Viteri, Guilherme; Conley, Patrick; Rothfels, Karen; Hermjakob, Henning; Stein, Lincoln; D'Eustachio, Peter; Wu, Guanming bioRxiv : the preprint server for biology 37333417 2023 Jun 05
An atlas of substrate specificities for the human serine/threonine kinome. Johnson, Jared L; Yaron, Tomer M; Huntsman, Emily M; Kerelsky, Alexander; Song, Junho; Regev, Amit; Lin, Ting-Yu; Liberatore, Katarina; Cizin, Daniel M; Cohen, Benjamin M; Vasan, Neil; Ma, Yilun; Krismer, Konstantin; Robles, Jaylissa Torres; van de Kooij, Bert; van Vlimmeren, Anne E; Andrée-Busch, Nicole; Käufer, Norbert F; Dorovkov, Maxim V; Ryazanov, Alexey G; Takagi, Yuichiro; Kastenhuber, Edward R; Goncalves, Marcus D; Hopkins, Benjamin D; Elemento, Olivier; Taatjes, Dylan J; Maucuer, Alexandre; Yamashita, Akio; Degterev, Alexei; Uduman, Mohamed; Lu, Jingyi; Landry, Sean D; Zhang, Bin; Cossentino, Ian; Linding, Rune; Blenis, John; Hornbeck, Peter V; Turk, Benjamin E; Yaffe, Michael B; Cantley, Lewis C Nature 36631611 2023 Jan
Kinome inhibition states and multiomics data enable prediction of cell viability in diverse cancer types. Berginski, Matthew E; Joisa, Chinmaya U; Golitz, Brian T; Gomez, Shawn M PLoS computational biology 36809237 2023 Feb
Proteomic approaches to study ubiquitinomics. Sahu, Indrajit; Zhu, He; Buhrlage, Sara J; Marto, Jarrod A Biochimica et biophysica acta. Gene regulatory mechanisms 37121501 2023 Jun
Pharos 2023: an integrated resource for the understudied human proteome. Kelleher, Keith J; Sheils, Timothy K; Mathias, Stephen L; Yang, Jeremy J; Metzger, Vincent T; Siramshetty, Vishal B; Nguyen, Dac-Trung; Jensen, Lars Juhl; Vidović, Dušica; Schürer, Stephan C; Holmes, Jayme; Sharma, Karlie R; Pillai, Ajay; Bologa, Cristian G; Edwards, Jeremy S; Mathé, Ewy A; Oprea, Tudor I Nucleic acids research 36624666 2023 Jan 06
TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins. Nguyen, Abraham; Goetz, Sarah C Molecular biology of the cell 36322399 2023 Jan 01
Centering on synaptic vesicle release. Young Jr, Samuel M Cell calcium 36527762 2023 Jan
SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Wu, Chien-Ting; Lidsky, Peter V; Xiao, Yinghong; Cheng, Ran; Lee, Ivan T; Nakayama, Tsuguhisa; Jiang, Sizun; He, Wei; Demeter, Janos; Knight, Miguel G; Turn, Rachel E; Rojas-Hernandez, Laura S; Ye, Chengjin; Chiem, Kevin; Shon, Judy; Martinez-Sobrido, Luis; Bertozzi, Carolyn R; Nolan, Garry P; Nayak, Jayakar V; Milla, Carlos; Andino, Raul; Jackson, Peter K Cell 36580912 2023 Jan 05
Accelerating inhibitor discovery for deubiquitinating enzymes. Chan, Wai Cheung; Liu, Xiaoxi; Magin, Robert S; Girardi, Nicholas M; Ficarro, Scott B; Hu, Wanyi; Tarazona Guzman, Maria I; Starnbach, Cara A; Felix, Alejandra; Adelmant, Guillaume; Varca, Anthony C; Hu, Bin; Bratt, Ariana S; DaSilva, Ethan; Schauer, Nathan J; Jaen Maisonet, Isabella; Dolen, Emma K; Ayala, Anthony X; Marto, Jarrod A; Buhrlage, Sara J Nature communications 36754960 2023 Feb 08
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. Ong, Han Wee; Liang, Yi; Richardson, William; Lowry, Emily R; Wells, Carrow I; Chen, Xiangrong; Silvestre, Margaux; Dempster, Kelvin; Silvaroli, Josie A; Smith, Jeffery L; Wichterle, Hynek; Pabla, Navjot S; Ultanir, Sila K; Bullock, Alex N; Drewry, David H; Axtman, Alison D bioRxiv : the preprint server for biology 36798313 2023 Feb 10
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells. Yang, Xuan; Smith, Jeffery L; Beck, Michael T; Wilkinson, Jennifer M; Michaud, Ani; Vasta, James D; Robers, Matthew B; Willson, Timothy M Molecules (Basel, Switzerland) 37049713 2023 Mar 25
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. Ong, Han Wee; Liang, Yi; Richardson, William; Lowry, Emily R; Wells, Carrow I; Chen, Xiangrong; Silvestre, Margaux; Dempster, Kelvin; Silvaroli, Josie A; Smith, Jeffery L; Wichterle, Hynek; Pabla, Navjot S; Ultanir, Sila K; Bullock, Alex N; Drewry, David H; Axtman, Alison D ACS chemical neuroscience 37084253 2023 May 03
SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response. Gruner, Hannah N; Zhang, Yaohuan; Shariati, Kaavian; Yiv, Nicholas; Hu, Zicheng; Wang, Yuhao; Hejtmancik, J Fielding; McManus, Michael T; Tharp, Kevin; Ku, Gregory PeerJ 37033725 2023
Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer. Chaudagar, Kiranj; Hieromnimon, Hanna M; Khurana, Rimpi; Labadie, Brian; Hirz, Taghreed; Mei, Shenglin; Hasan, Raisa; Shafran, Jordan; Kelley, Anne; Apostolov, Eva; Al-Eryani, Ghamdan; Harvey, Kate; Rameshbabu, Srikrishnan; Loyd, Mayme; Bynoe, Kaela; Drovetsky, Catherine; Solanki, Ani; Markiewicz, Erica; Zamora, Marta; Fan, Xiaobing; Schürer, Stephan; Swarbrick, Alex; Sykes, David B; Patnaik, Akash Clinical cancer research : an official journal of the American Association for Cancer Research 36862086 2023 May 15
Computational screen to identify potential targets for immunotherapeutic identification and removal of senescence cells. Deng, Eden Z; Fleishman, Reid H; Xie, Zhuorui; Marino, Giacomo B; Clarke, Daniel J B; Ma'ayan, Avi Aging cell 37082798 2023 Jun
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski, Martin; Lius, Andrea; Sapre, Tanmay; Lau, Ho-Tak; Moreno, Taylor; Maly, Dustin J; Ong, Shao-En Molecular cell 36736316 2023 Mar 02
lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs. Marino, Giacomo B; Wojciechowicz, Megan L; Clarke, Daniel J B; Kuleshov, Maxim V; Xie, Zhuorui; Jeon, Minji; Lachmann, Alexander; Ma'ayan, Avi Database : the journal of biological databases and curation 36869839 2023 Mar 04
Illuminating the druggable genome through patent bioactivity data. Magariños, Maria P; Gaulton, Anna; Félix, Eloy; Kiziloren, Tevfik; Arcila, Ricardo; Oprea, Tudor I; Leach, Andrew R PeerJ 37151295 2023
Using the Reactome Database. Rothfels, Karen; Milacic, Marija; Matthews, Lisa; Haw, Robin; Sevilla, Cristoffer; Gillespie, Marc; Stephan, Ralf; Gong, Chuqiao; Ragueneau, Eliot; May, Bruce; Shamovsky, Veronica; Wright, Adam; Weiser, Joel; Beavers, Deidre; Conley, Patrick; Tiwari, Krishna; Jassal, Bijay; Griss, Johannes; Senff-Ribeiro, Andrea; Brunson, Timothy; Petryszak, Robert; Hermjakob, Henning; D'Eustachio, Peter; Wu, Guanming; Stein, Lincoln Current protocols 37053306 2023 Apr
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Liu, Yongfeng; Cao, Can; Huang, Xi-Ping; Gumpper, Ryan H; Rachman, Moira M; Shih, Sheng-Luen; Krumm, Brian E; Zhang, Shicheng; Shoichet, Brian K; Fay, Jonathan F; Roth, Bryan L Nature chemical biology 36302898 2023 Apr
Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor. Decker, Ann M; Rahman, Md Toufiqur; Kormos, Chad M; Hesk, David; Darcq, Emmanuel; Kieffer, Brigitte L; Jin, Chunyang Bioorganic & medicinal chemistry letters 36587872 2023 Jan 15
Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels. Lee, Sun-Joo; Nichols, Colin G The Journal of general physiology 36524992 2023 Feb 06
DrugCentral 2023 extends human clinical data and integrates veterinary drugs. Avram, Sorin; Wilson, Thomas B; Curpan, Ramona; Halip, Liliana; Borota, Ana; Bora, Alina; Bologa, Cristian G; Holmes, Jayme; Knockel, Jeffrey; Yang, Jeremy J; Oprea, Tudor I Nucleic acids research 36484092 2023 Jan 06
SGC-CAMKK2-1: A Chemical Probe for CAMKK2. Wells, Carrow; Liang, Yi; Pulliam, Thomas L; Lin, Chenchu; Awad, Dominik; Eduful, Benjamin; O'Byrne, Sean; Hossain, Mohammad Anwar; Catta-Preta, Carolina Moura Costa; Ramos, Priscila Zonzini; Gileadi, Opher; Gileadi, Carina; Couñago, Rafael M; Stork, Brittany; Langendorf, Christopher G; Nay, Kevin; Oakhill, Jonathan S; Mukherjee, Debarati; Racioppi, Luigi; Means, Anthony R; York, Brian; McDonnell, Donald P; Scott, John W; Frigo, Daniel E; Drewry, David H Cells 36672221 2023 Jan 11
GeneRanger and TargetRanger: processed gene and protein expression levels across cells and tissues for target discovery. Marino, Giacomo B; Ngai, Michael; Clarke, Daniel J B; Fleishman, Reid H; Deng, Eden Z; Xie, Zhuorui; Ahmed, Nasheath; Ma'ayan, Avi Nucleic acids research 37166966 2023 Jul 05
The structure, function, and pharmacology of MRGPRs. Cao, Can; Roth, Bryan L Trends in pharmacological sciences 36870785 2023 Apr
Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity. Choi, Yuna; Min, Hyeon-Young; Hwang, Jiyeon; Jo, Young-Hwan Life science alliance 36007929 2022 Nov
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion. Yan, Shijun; Conley, Jason M; Reilly, Austin M; Stull, Natalie D; Abhyankar, Surabhi D; Ericsson, Aaron C; Kono, Tatsuyoshi; Molosh, Andrei I; Kubal, Chandrashekhar A; Evans-Molina, Carmella; Ren, Hongxia Cell reports 34986353 2022 Jan 04
Neuropeptide B/W receptor 1 peptidomimetic agonists: Structure-activity relationships and plasma stability. Nguyen, Thuy; Decker, Ann M; Snyder, Rodney W; Tonetti, Emma C; Gamage, Thomas F; Zhang, Yanan European journal of medicinal chemistry 35101647 2022 Mar 05
Investigating the Therapeutic Potential of Cdk8 Small Molecule Inhibitors to Prevent Pathological Cardiac Remodeling and Heart Failure. Oppman, Alexis M; Gardner, Richard N; Martins, Ines; Minerath, Rachel A; Hall, Duane D; Grueter, Chad E FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35553110 2022 May
A Learning Based Framework for Disease Prediction from Images of Human-Derived Pluripotent Stem Cells of Schizophrenia Patients. Fularczyk, Nickolas; Di Re, Jessica; Stertz, Laura; Walss-Bass, Consuelo; Laezza, Fernanda; Labate, Demetrio Neuroinformatics 35064871 2022 Apr
Gene and drug landing page aggregator. Clarke, Daniel J B; Kuleshov, Maxim V; Xie, Zhuorui; Evangelista, John E; Meyers, Marilyn R; Kropiwnicki, Eryk; Jenkins, Sherry L; Ma'ayan, Avi Bioinformatics advances 35368424 2022
SigCom LINCS: data and metadata search engine for a million gene expression signatures. Evangelista, John Erol; Clarke, Daniel J B; Xie, Zhuorui; Lachmann, Alexander; Jeon, Minji; Chen, Kerwin; Jagodnik, Kathleen M; Jenkins, Sherry L; Kuleshov, Maxim V; Wojciechowicz, Megan L; Schürer, Stephan C; Medvedovic, Mario; Ma'ayan, Avi Nucleic acids research 35524556 2022 Jul 05
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer. Schirmer, Amelia U; Driver, Lucy M; Zhao, Megan T; Wells, Carrow I; Pickett, Julie E; O'Bryne, Sean N; Eduful, Benjamin J; Yang, Xuan; Howard, Lauren; You, Sungyong; Devi, Gayathri R; DiGiovanni, John; Freedland, Stephen J; Chi, Jen-Tsan; Drewry, David H; Macias, Everardo Molecular therapy : the journal of the American Society of Gene Therapy 34450249 2022 Jan 05
Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition. East, Michael P; Johnson, Gary L The Journal of biological chemistry 34958800 2022 Feb
Inactive and active state structures template selective tools for the human 5-HT5A receptor. Zhang, Shicheng; Chen, He; Zhang, Chengwei; Yang, Ying; Popov, Petr; Liu, Jing; Krumm, Brian E; Cao, Can; Kim, Kuglae; Xiong, Yan; Katritch, Vsevolod; Shoichet, Brian K; Jin, Jian; Fay, Jonathan F; Roth, Bryan L Nature structural & molecular biology 35835867 2022 Jul
Molecular basis for selective activation of DREADD-based chemogenetics. Zhang, Shicheng; Gumpper, Ryan H; Huang, Xi-Ping; Liu, Yongfeng; Krumm, Brian E; Cao, Can; Fay, Jonathan F; Roth, Bryan L Nature 36450989 2022 Dec
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. Drewry, David H; Annor-Gyamfi, Joel K; Wells, Carrow I; Pickett, Julie E; Dederer, Verena; Preuss, Franziska; Mathea, Sebastian; Axtman, Alison D Journal of medicinal chemistry 34333981 2022 01 27
blitzGSEA: efficient computation of gene set enrichment analysis through gamma distribution approximation. Lachmann, Alexander; Xie, Zhuorui; Ma'ayan, Avi Bioinformatics (Oxford, England) 35143610 2022 Apr 12
Identification of RIOK2 as a master regulator of human blood cell development. Ghosh, Shrestha; Raundhal, Mahesh; Myers, Samuel A; Carr, Steven A; Chen, Xi; Petsko, Gregory A; Glimcher, Laurie H Nature immunology 34937919 2022 Jan
The potassium channel auxiliary subunit Kvβ2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing. Yee, Joshua X; Rastani, Ariana; Soden, Marta E Journal of neurophysiology 35788155 2022 Jul 01
Analysis of human Tribbles 2 (TRIB2) pseudokinase. Harris, John A; Fairweather, Emma; Byrne, Dominic P; Eyers, Patrick A Methods in enzymology 35525562 2022
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity. Binder, Jessica; Ursu, Oleg; Bologa, Cristian; Jiang, Shanya; Maphis, Nicole; Dadras, Somayeh; Chisholm, Devon; Weick, Jason; Myers, Orrin; Kumar, Praveen; Yang, Jeremy J; Bhaskar, Kiran; Oprea, Tudor I Communications biology 35149761 2022 Feb 11
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding. Ackloo, Suzanne; Al-Awar, Rima; Amaro, Rommie E; Arrowsmith, Cheryl H; Azevedo, Hatylas; Batey, Robert A; Bengio, Yoshua; Betz, Ulrich A K; Bologa, Cristian G; Chodera, John D; Cornell, Wendy D; Dunham, Ian; Ecker, Gerhard F; Edfeldt, Kristina; Edwards, Aled M; Gilson, Michael K; Gordijo, Claudia R; Hessler, Gerhard; Hillisch, Alexander; Hogner, Anders; Irwin, John J; Jansen, Johanna M; Kuhn, Daniel; Leach, Andrew R; Lee, Alpha A; Lessel, Uta; Morgan, Maxwell R; Moult, John; Muegge, Ingo; Oprea, Tudor I; Perry, Benjamin G; Riley, Patrick; Rousseaux, Sophie A L; Saikatendu, Kumar Singh; Santhakumar, Vijayaratnam; Schapira, Matthieu; Scholten, Cora; Todd, Matthew H; Vedadi, Masoud; Volkamer, Andrea; Willson, Timothy M Nature reviews. Chemistry 35783295 2022 Apr
DrugShot: querying biomedical search terms to retrieve prioritized lists of small molecules. Kropiwnicki, Eryk; Lachmann, Alexander; Clarke, Daniel J B; Xie, Zhuorui; Jagodnik, Kathleen M; Ma'ayan, Avi BMC bioinformatics 35183110 2022 Feb 19
Getting Started with LINCS Datasets and Tools. Xie, Zhuorui; Kropiwnicki, Eryk; Wojciechowicz, Megan L; Jagodnik, Kathleen M; Shu, Ingrid; Bailey, Allison; Clarke, Daniel J B; Jeon, Minji; Evangelista, John Erol; V Kuleshov, Maxim; Lachmann, Alexander; Parigi, Abhijna A; Sanchez, Jose M; Jenkins, Sherry L; Ma'ayan, Avi Current protocols 35876555 2022 Jul
A Superfolder Green Fluorescent Protein-Based Biosensor Allows Monitoring of Chloride in the Endoplasmic Reticulum. Shariati, Kaavian; Zhang, Yaohuan; Giubbolini, Simone; Parra, Riccardo; Liang, Steven; Edwards, Austin; Hejtmancik, J Fielding; Ratto, Gian Michele; Arosio, Daniele; Ku, Gregory ACS sensors 35951356 2022 Aug 26
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Simon, Bertrand; Lou, Hua Jane; Huet-Calderwood, Clotilde; Shi, Guangda; Boggon, Titus J; Turk, Benjamin E; Calderwood, David A Nature communications 35136069 2022 Feb 08
The Tails of Protein Kinase A. Taylor, Susan S; Søberg, Kristoffer; Kobori, Evan; Wu, Jian; Pautz, Sabine; Herberg, Friedrich W; Skålhegg, Bjørn Steen Molecular pharmacology 34330820 2022 Apr
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Zhuang, Youwen; Wang, Lei; Guo, Jia; Sun, Dapeng; Wang, Yue; Liu, Weiyi; Xu, H Eric; Zhang, Cheng Nature communications 35217703 2022 Feb 25
Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Xu, Wenjing; Nelson-Maney, Nathan P; Bálint, László; Kwon, Hyouk-Bum; Davis, Reema B; Dy, Danielle C M; Dunleavey, James M; St Croix, Brad; Caron, Kathleen M International journal of molecular sciences 35628521 2022 May 20
Ectopic biomolecular phase transitions: fusion proteins in cancer pathologies. Davis, Richoo B; Moosa, Mahdi Muhammad; Banerjee, Priya R Trends in cell biology 35484036 2022 Aug
CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection. Ponnalagu, Devasena; Hamilton, Shanna; Sanghvi, Shridhar; Antelo, Diego; Schwieterman, Neill; Hansra, Inderjot; Xu, Xianyao; Gao, Erhe; Edwards, John C; Bansal, Shyam S; Wold, Loren E; Terentyev, Dmitry; Janssen, Paul M L; Hund, Thomas J; Khan, Mahmood; Kohut, Andrew R; Koch, Walter J; Singh, Harpreet Science advances 36269835 2022 Oct 21
The reactome pathway knowledgebase 2022. Gillespie, Marc; Jassal, Bijay; Stephan, Ralf; Milacic, Marija; Rothfels, Karen; Senff-Ribeiro, Andrea; Griss, Johannes; Sevilla, Cristoffer; Matthews, Lisa; Gong, Chuqiao; Deng, Chuan; Varusai, Thawfeek; Ragueneau, Eliot; Haider, Yusra; May, Bruce; Shamovsky, Veronica; Weiser, Joel; Brunson, Timothy; Sanati, Nasim; Beckman, Liam; Shao, Xiang; Fabregat, Antonio; Sidiropoulos, Konstantinos; Murillo, Julieth; Viteri, Guilherme; Cook, Justin; Shorser, Solomon; Bader, Gary; Demir, Emek; Sander, Chris; Haw, Robin; Wu, Guanming; Stein, Lincoln; Hermjakob, Henning; D'Eustachio, Peter Nucleic acids research 34788843 2022 01 07
Protein kinase inhibitor selectivity "hinges" on evolution. Shrestha, Safal; Bendzunas, George; Kannan, Natarajan Structure (London, England : 1993) 36459973 2022 Dec 01
Transforming L1000 profiles to RNA-seq-like profiles with deep learning. Jeon, Minji; Xie, Zhuorui; Evangelista, John E; Wojciechowicz, Megan L; Clarke, Daniel J B; Ma'ayan, Avi BMC bioinformatics 36100892 2022 Sep 13
Autophagy and Herpesvirus: A collaboration Contributing to Alzheimer's Disease. Nafchi, Amir R; Esmaeili, Mona; Myers, Orrin; Oprea, Tudor; Bearer, Elane L FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35723876 2022 May
Open source fraction collector/MALDI spotter for proteomics. Ficarro, Scott B; Max Alexander, William; Tavares, Isidoro; Marto, Jarrod A HardwareX 35518277 2022 Apr
Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma. Essegian, Derek J; Chavez, Valery; Bustamante, Floritza; Schürer, Stephan C; Merchan, Jaime R iScience 36465101 2022 Dec 22
RIOK3 and Its Alternatively Spliced Isoform Have Disparate Roles in the Innate Immune Response to Rift Valley Fever Virus (MP12) Infection. Bisom, Thomas C; White, Luke A; Lanchy, Jean-Marc; Lodmell, J Stephen Viruses 36146870 2022 Sep 17
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction. Happ, John T; Arveseth, Corvin D; Bruystens, Jessica; Bertinetti, Daniela; Nelson, Isaac B; Olivieri, Cristina; Zhang, Jingyi; Hedeen, Danielle S; Zhu, Ju-Fen; Capener, Jacob L; Bröckel, Jan W; Vu, Lily; King, C C; Ruiz-Perez, Victor L; Ge, Xuecai; Veglia, Gianluigi; Herberg, Friedrich W; Taylor, Susan S; Myers, Benjamin R Nature structural & molecular biology 36202993 2022 Oct
Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice. Min, Hyeon-Young; Hwang, Jiyeon; Choi, Yuna; Jo, Young-Hwan American journal of physiology. Endocrinology and metabolism 35830691 2022 Sep 01
Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype. Asquith, Christopher R M; Temme, Louisa; East, Michael P; Laitinen, Tuomo; Pickett, Julie; Kwarcinski, Frank E; Sinha, Parvathi; Wells, Carrow I; Johnson, Gary L; Zutshi, Reena; Drewry, David H ChemMedChem 35403825 2022 Jun 20
Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop. Mills, Caitlin E; Subramanian, Kartik; Hafner, Marc; Niepel, Mario; Gerosa, Luca; Chung, Mirra; Victor, Chiara; Gaudio, Benjamin; Yapp, Clarence; Nirmal, Ajit J; Clark, Nicholas; Sorger, Peter K Nature communications 36376301 2022 Nov 14
AlphaFold illuminates half of the dark human proteins. Binder, Jessica L; Berendzen, Joel; Stevens, Amy O; He, Yi; Wang, Jian; Dokholyan, Nikolay V; Oprea, Tudor I Current opinion in structural biology 35439658 2022 Jun
Agonist and antagonist TRUPATH assays for G protein-coupled receptors. DiBerto, Jeffrey F; Smart, Katie; Olsen, Reid H J; Roth, Bryan L STAR protocols 35403009 2022 Jun 17
Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2. Yang, Xuan; Dickmander, Rebekah J; Bayati, Armin; Taft-Benz, Sharon A; Smith, Jeffery L; Wells, Carrow I; Madden, Emily A; Brown, Jason W; Lenarcic, Erik M; Yount Jr, Boyd L; Chang, Edcon; Axtman, Alison D; Baric, Ralph S; Heise, Mark T; McPherson, Peter S; Moorman, Nathaniel J; Willson, Timothy M bioRxiv : the preprint server for biology 35018375 2022 Jan 26
EMBER: multi-label prediction of kinase-substrate phosphorylation events through deep learning. Kirchoff, Kathryn E; Gomez, Shawn M Bioinformatics (Oxford, England) 35157015 2022 Apr 12
On-Chip Preconcentration Microchip Capillary Electrophoresis Based CE-PRM-LIVE for High-Throughput Selectivity Profiling of Deubiquitinase Inhibitors. Zhu, He; Mellors, J Scott; Chan, Wai Cheung; Thompson, J Will; Ficarro, Scott B; Tavares, Isidoro; Bratt, Ariana S; Decker, Jens; Krause, Michael; Kruppa, Gary; Buhrlage, Sara J; Marto, Jarrod A Analytical chemistry 35729701 2022 Jul 12
Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patients. Kaur, Navchetan; Oskotsky, Boris; Butte, Atul J; Hu, Zicheng Genome biology 35012625 2022 Jan 10
The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice. Klomp, Annette; Omichi, Ryotaro; Iwasa, Yoichiro; Smith, Richard J; Usachev, Yuriy M; Russo, Andrew F; Narayanan, Nandakumar S; Lee, Amy PloS one 35353835 2022
Calcium Channels in Retinal Function and Disease. Williams, Brittany; Maddox, J Wesley; Lee, Amy Annual review of vision science 35650675 2022 Sep 15
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How to Illuminate the Druggable Genome Using Pharos. Sheils, Timothy; Mathias, Stephen L; Siramshetty, Vishal B; Bocci, Giovanni; Bologa, Cristian G; Yang, Jeremy J; Waller, Anna; Southall, Noel; Nguyen, Dac-Trung; Oprea, Tudor I Current protocols in bioinformatics 31898878 2020 03
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Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards, Jonathan J; Rouillard, Andrew D; Fernandez, Nicolas F; Wang, Zichen; Lachmann, Alexander; Shankaran, Sunita S; Bisgrove, Brent W; Demarest, Bradley; Turan, Nahid; Srivastava, Deepak; Bernstein, Daniel; Deanfield, John; Giardini, Alessandro; Porter, George; Kim, Richard; Roberts, Amy E; Newburger, Jane W; Goldmuntz, Elizabeth; Brueckner, Martina; Lifton, Richard P; Seidman, Christine E; Chung, Wendy K; Tristani-Firouzi, Martin; Yost, H Joseph; Ma'ayan, Avi; Gelb, Bruce D JACC. Basic to translational science 32368696 2020 Apr
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Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nagai, Yuji; Miyakawa, Naohisa; Takuwa, Hiroyuki; Hori, Yukiko; Oyama, Kei; Ji, Bin; Takahashi, Manami; Huang, Xi-Ping; Slocum, Samuel T; DiBerto, Jeffrey F; Xiong, Yan; Urushihata, Takuya; Hirabayashi, Toshiyuki; Fujimoto, Atsushi; Mimura, Koki; English, Justin G; Liu, Jing; Inoue, Ken-Ichi; Kumata, Katsushi; Seki, Chie; Ono, Maiko; Shimojo, Masafumi; Zhang, Ming-Rong; Tomita, Yutaka; Nakahara, Jin; Suhara, Tetsuya; Takada, Masahiko; Higuchi, Makoto; Jin, Jian; Roth, Bryan L; Minamimoto, Takafumi Nature neuroscience 32632286 2020 09
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Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Gibbons, Garrett S; Chakraborty, Amarraj; Grigsby, Sierrah M; Umeano, Afoma C; Liao, Chenzhong; Moukha-Chafiq, Omar; Pathak, Vibha; Mathew, Bini; Lee, Young-Tae; Dou, Yali; Schürer, Stephan C; Reynolds, Robert C; Snowden, Timothy S; Nikolovska-Coleska, Zaneta European journal of medicinal chemistry 31978781 2020 Mar 01
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An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. Luna, Lucas A; Lesecq, Zachary; White, Katharine A; Hoang, An; Scott, David A; Zagnitko, Olga; Bobkov, Andrey A; Barber, Diane L; Schiffer, Jamie M; Isom, Daniel G; Sohl, Christal D The Biochemical journal 32729927 2020 08 28
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Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. Nath, Anjali K; Ma, Junyan; Chen, Zsu-Zsu; Li, Zhuyun; Vitery, Maria Del Carmen; Kelley, Michelle L; Peterson, Randall T; Gerszten, Robert E; Yeh, Jing-Ruey J FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31914600 2020 01
Discrete Adaptive Responses to MEK Inhibitor in Subpopulations of Triple-Negative Breast Cancer. Goulet, Daniel R; Foster 2nd, Joseph P; Zawistowski, Jon S; Bevill, Samantha M; Noël, Mélodie P; Olivares-Quintero, José F; Sciaky, Noah; Singh, Darshan; Santos, Charlene; Pattenden, Samantha G; Davis, Ian J; Johnson, Gary L Molecular cancer research : MCR 32753473 2020 11
Concise, gram-scale synthesis of furo[2,3-b]pyridines with functional handles for chemoselective cross-coupling. O'Byrne, Sean N; Eduful, Benjamin J; Willson, Timothy M; Drewry, David H Tetrahedron letters 33012852 2020 Sep 17
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer. Essegian, Derek; Khurana, Rimpi; Stathias, Vasileios; Schürer, Stephan C Cell reports. Medicine 33205077 2020 10 20
Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction. Huang, Liang-Chin; Yeung, Wayland; Wang, Ye; Cheng, Huimin; Venkat, Aarya; Li, Sheng; Ma, Ping; Rasheed, Khaled; Kannan, Natarajan BMC bioinformatics 33183223 2020 Nov 12
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. Picado, Alfredo; Chaikuad, Apirat; Wells, Carrow I; Shrestha, Safal; Zuercher, William J; Pickett, Julie E; Kwarcinski, Frank E; Sinha, Parvathi; de Silva, Chandi S; Zutshi, Reena; Liu, Shubin; Kannan, Natarajan; Knapp, Stefan; Drewry, David H; Willson, Timothy M Journal of medicinal chemistry 33215924 2020 12 10
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Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19. Bocci, Giovanni; Bradfute, Steven B; Ye, Chunyan; Garcia, Matthew J; Parvathareddy, Jyothi; Reichard, Walter; Surendranathan, Surekha; Bansal, Shruti; Bologa, Cristian G; Perkins, Douglas J; Jonsson, Colleen B; Sklar, Larry A; Oprea, Tudor I ACS pharmacology & translational science 33330842 2020 Dec 11
A Semi-automated and Scalable 3D Spheroid Assay to Study Neuroblast Migration. Ducker, Martin; Millar, Valerie; Ebner, Daniel; Szele, Francis G Stem cell reports 32763162 2020 09 08
Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen. Smith, Milo R; Yevoo, Priscilla; Sadahiro, Masato; Readhead, Ben; Kidd, Brian; Dudley, Joel T; Morishita, Hirofumi Neural plasticity 32454811 2020
SmartGraph: a network pharmacology investigation platform. Zahoránszky-Kőhalmi, Gergely; Sheils, Timothy; Oprea, Tudor I Journal of cheminformatics 33430980 2020 Jan 21
Presynaptic calcium channels: specialized control of synaptic neurotransmitter release. Dolphin, Annette C; Lee, Amy Nature reviews. Neuroscience 32161339 2020 04
CRISPR-addressable yeast strains with applications in human G protein-coupled receptor profiling and synthetic biology. Rowe, Jacob B; Taghon, Geoffrey J; Kapolka, Nicholas J; Morgan, William M; Isom, Daniel G The Journal of biological chemistry 32358068 2020 06 12
Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. Jones, Alexander C; Taylor, Susan S; Newton, Alexandra C; Kornev, Alexandr P IUBMB life 33166426 2020 12
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Palencia-Campos, Adrian; Aoto, Phillip C; Machal, Erik M F; Rivera-Barahona, Ana; Soto-Bielicka, Patricia; Bertinetti, Daniela; Baker, Blaine; Vu, Lily; Piceci-Sparascio, Francesca; Torrente, Isabella; Boudin, Eveline; Peeters, Silke; Van Hul, Wim; Huber, Celine; Bonneau, Dominique; Hildebrand, Michael S; Coleman, Matthew; Bahlo, Melanie; Bennett, Mark F; Schneider, Amy L; Scheffer, Ingrid E; Kibæk, Maria; Kristiansen, Britta S; Issa, Mahmoud Y; Mehrez, Mennat I; Ismail, Samira; Tenorio, Jair; Li, Gaoyang; Skålhegg, Bjørn Steen; Otaify, Ghada A; Temtamy, Samia; Aglan, Mona; Jønch, Aia E; De Luca, Alessandro; Mortier, Geert; Cormier-Daire, Valérie; Ziegler, Alban; Wallis, Mathew; Lapunzina, Pablo; Herberg, Friedrich W; Taylor, Susan S; Ruiz-Perez, Victor L American journal of human genetics 33058759 2020 11 05
Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production. Kwon, Eunjin; Joung, Hye-Young; Liu, Shun-Mei; Chua Jr, Streamson C; Schwartz, Gary J; Jo, Young-Hwan Nature communications 33293550 2020 12 08
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GPR84: an immune response dial? Wojciechowicz, Megan L; Ma'ayan, Avi Nature reviews. Drug discovery 32494048 2020 Jun
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Cataloguing the dead: breathing new life into pseudokinase research. Shrestha, Safal; Byrne, Dominic P; Harris, John A; Kannan, Natarajan; Eyers, Patrick A The FEBS journal 32053275 2020 10
Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease. Yeung, Wayland; Ruan, Zheng; Kannan, Natarajan IUBMB life 32101380 2020 06
Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Stein, Reed M; Kang, Hye Jin; McCorvy, John D; Glatfelter, Grant C; Jones, Anthony J; Che, Tao; Slocum, Samuel; Huang, Xi-Ping; Savych, Olena; Moroz, Yurii S; Stauch, Benjamin; Johansson, Linda C; Cherezov, Vadim; Kenakin, Terry; Irwin, John J; Shoichet, Brian K; Roth, Bryan L; Dubocovich, Margarita L Nature 32040955 2020 03
In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds. O'Byrne, Sean N; Scott, John W; Pilotte, Joseph R; Santiago, André da S; Langendorf, Christopher G; Oakhill, Jonathan S; Eduful, Benjamin J; Couñago, Rafael M; Wells, Carrow I; Zuercher, William J; Willson, Timothy M; Drewry, David H Molecules (Basel, Switzerland) 31941153 2020 Jan 13
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. Moret, Nienke; Clark, Nicholas A; Hafner, Marc; Wang, Yuan; Lounkine, Eugen; Medvedovic, Mario; Wang, Jinhua; Gray, Nathanael; Jenkins, Jeremy; Sorger, Peter K Cell chemical biology 30956147 2019 05 16
GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer. Bevill, Samantha M; Olivares-Quintero, Jose F; Sciaky, Noah; Golitz, Brian T; Singh, Darshan; Beltran, Adriana S; Rashid, Naim U; Stuhlmiller, Timothy J; Hale, Andrew; Moorman, Nathaniel J; Santos, Charlene M; Angus, Steven P; Zawistowski, Jon S; Johnson, Gary L Molecular cancer research : MCR 31000582 2019 07
An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking. Kozlitina, Julia; Risso, Davide; Lansu, Katherine; Olsen, Reid Hans Johnson; Sainz, Eduardo; Luiselli, Donata; Barik, Arnab; Frigerio-Domingues, Carlos; Pagani, Luca; Wooding, Stephen; Kirchner, Thomas; Niaura, Ray; Roth, Bryan; Drayna, Dennis PLoS genetics 30768591 2019 02
Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs. Roth, Bryan L Nature structural & molecular biology 31270468 2019 07
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Agajanian, Megan J; Walker, Matthew P; Axtman, Alison D; Ruela-de-Sousa, Roberta R; Serafin, D Stephen; Rabinowitz, Alex D; Graham, David M; Ryan, Meagan B; Tamir, Tigist; Nakamichi, Yuko; Gammons, Melissa V; Bennett, James M; Couñago, Rafael M; Drewry, David H; Elkins, Jonathan M; Gileadi, Carina; Gileadi, Opher; Godoi, Paulo H; Kapadia, Nirav; Müller, Susanne; Santiago, André S; Sorrell, Fiona J; Wells, Carrow I; Fedorov, Oleg; Willson, Timothy M; Zuercher, William J; Major, Michael B Cell reports 30605688 2019 01 02
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Ferguson, Fleur M; Doctor, Zainab M; Ficarro, Scott B; Browne, Christopher M; Marto, Jarrod A; Johnson, Jared L; Yaron, Tomer M; Cantley, Lewis C; Kim, Nam Doo; Sim, Taebo; Berberich, Matthew J; Kalocsay, Marian; Sorger, Peter K; Gray, Nathanael S Cell chemical biology 30930164 2019 06 20
OSCI: standardized stem cell ontology representation and use cases for stem cell investigation. He, Yongqun; Duncan, William D; Cooper, Daniel J; Hansen, Jens; Iyengar, Ravi; Ong, Edison; Walker, Kendal; Tibi, Omar; Smith, Sam; Serra, Lucas M; Zheng, Jie; Sarntivijai, Sirarat; Schürer, Stephan; O'Shea, K Sue; Diehl, Alexander D BMC bioinformatics 31272389 2019 Apr 25
Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder. Smith, Milo R; Readhead, Ben; Dudley, Joel T; Morishita, Hirofumi Schizophrenia research 30442475 2019 05
How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM). Küçük McGinty, Hande; Visser, Ubbo; Schürer, Stephan Methods in molecular biology (Clifton, N.J.) 30848456 2019
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. McCarroll, Matthew N; Gendelev, Leo; Kinser, Reid; Taylor, Jack; Bruni, Giancarlo; Myers-Turnbull, Douglas; Helsell, Cole; Carbajal, Amanda; Rinaldi, Capria; Kang, Hye Jin; Gong, Jung Ho; Sello, Jason K; Tomita, Susumu; Peterson, Randall T; Keiser, Michael J; Kokel, David Nature communications 31501447 2019 09 09
Ultra-large library docking for discovering new chemotypes. Lyu, Jiankun; Wang, Sheng; Balius, Trent E; Singh, Isha; Levit, Anat; Moroz, Yurii S; O'Meara, Matthew J; Che, Tao; Algaa, Enkhjargal; Tolmachova, Kateryna; Tolmachev, Andrey A; Shoichet, Brian K; Roth, Bryan L; Irwin, John J Nature 30728502 2019 02
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. Martini, Michael L; Liu, Jing; Ray, Caroline; Yu, Xufen; Huang, Xi-Ping; Urs, Aarti; Urs, Nikhil; McCorvy, John D; Caron, Marc G; Roth, Bryan L; Jin, Jian Journal of medicinal chemistry 30875219 2019 04 11
Structural basis of ligand recognition at the human MT1 melatonin receptor. Stauch, Benjamin; Johansson, Linda C; McCorvy, John D; Patel, Nilkanth; Han, Gye Won; Huang, Xi-Ping; Gati, Cornelius; Batyuk, Alexander; Slocum, Samuel T; Ishchenko, Andrii; Brehm, Wolfgang; White, Thomas A; Michaelian, Nairie; Madsen, Caleb; Zhu, Lan; Grant, Thomas D; Grandner, Jessica M; Shiriaeva, Anna; Olsen, Reid H J; Tribo, Alexandra R; Yous, Saïd; Stevens, Raymond C; Weierstall, Uwe; Katritch, Vsevolod; Roth, Bryan L; Liu, Wei; Cherezov, Vadim Nature 31019306 2019 05
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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Asquith, Christopher R M; Berger, Benedict-Tilman; Wan, Jing; Bennett, James M; Capuzzi, Stephen J; Crona, Daniel J; Drewry, David H; East, Michael P; Elkins, Jonathan M; Fedorov, Oleg; Godoi, Paulo H; Hunter, Debra M; Knapp, Stefan; Müller, Susanne; Torrice, Chad D; Wells, Carrow I; Earp, H Shelton; Willson, Timothy M; Zuercher, William J Journal of medicinal chemistry 30768268 2019 03 14
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Research Techniques Made Simple: Molecular Docking in Dermatology - A Foray into In Silico Drug Discovery. Issa, Naiem T; Badiavas, Evangelos V; Schürer, Stephan The Journal of investigative dermatology 31753122 2019 12
Recombination drives the evolution of mutational robustness. Singhal, Sonia; Gomez, Shawn M; Burch, Christina L Current opinion in systems biology 31572829 2019 Feb
ADCK3/COQ8A: the choice target of the UbiB protein kinase-like family. Asquith, Christopher R M; Murray, Nathan H; Pagliarini, David J Nature reviews. Drug discovery 31673128 2019 Oct
Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. Boettcher, Michael; Covarrubias, Sergio; Biton, Anne; Blau, James; Wang, Haopeng; Zaitlen, Noah; McManus, Michael T BMC genomics 30727954 2019 Feb 06
Improving the Utility of the Tox21 Dataset by Deep Metadata Annotations and Constructing Reusable Benchmarked Chemical Reference Signatures. Cooper, Daniel J; Schürer, Stephan Molecules (Basel, Switzerland) 31018579 2019 Apr 23
Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits. Glicksberg, Benjamin S; Amadori, Letizia; Akers, Nicholas K; Sukhavasi, Katyayani; Franzén, Oscar; Li, Li; Belbin, Gillian M; Ayers, Kristin L; Shameer, Khader; Badgeley, Marcus A; Johnson, Kipp W; Readhead, Ben; Darrow, Bruce J; Kenny, Eimear E; Betsholtz, Christer; Ermel, Raili; Skogsberg, Josefin; Ruusalepp, Arno; Schadt, Eric E; Dudley, Joel T; Ren, Hongxia; Kovacic, Jason C; Giannarelli, Chiara; Li, Shuyu D; Björkegren, Johan L M; Chen, Rong BMC medical genomics 31345219 2019 07 25
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VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. English, Justin G; Olsen, Reid H J; Lansu, Katherine; Patel, Michael; White, Karoline; Cockrell, Adam S; Singh, Darshan; Strachan, Ryan T; Wacker, Daniel; Roth, Bryan L Cell 31398329 2019 Aug 08
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma. Wong, Jason P; Stuhlmiller, Timothy J; Giffin, Louise C; Lin, Carolina; Bigi, Rachele; Zhao, Jichen; Zhang, Weihe; Bravo Cruz, Ariana G; Park, Steven I; Earp, H Shelton; Dittmer, Dirk P; Frye, Stephen V; Wang, Xiaodong; Johnson, Gary L; Damania, Blossom Proceedings of the National Academy of Sciences of the United States of America 31346082 2019 08 13
The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region. Agnew, Christopher; Liu, Lijun; Liu, Shu; Xu, Wei; You, Liang; Yeung, Wayland; Kannan, Natarajan; Jablons, David; Jura, Natalia The Journal of biological chemistry 31341017 2019 Sep 13
Predicting opioid dependence from electronic health records with machine learning. Ellis, Randall J; Wang, Zichen; Genes, Nicholas; Ma'ayan, Avi BioData mining 30728857 2019
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