Funded Research

 

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-21-012
PI Name Institution Name Title
CAO, ERHU UNIVERSITY OF UTAH Develop enabling biochemical and structural tools for dissecting the roles of PKD2L2 in metabolism
DELLING, MARKUS G UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Functional characterization of the dark matter ion channel polycystin2-like2

FESKE, STEFAN (contact) 
COETZEE, WILLIAM A

 NEW YORK UNIVERSITY SCHOOL OF MEDICINE FAM26F function and role in macrophages
JACKSON, PETER KENT STANFORD UNIVERSITY Understudied GPCRs connecting signaling in primary cilia to obesity and metabolic disease
KHAN, MOHD NAZIR EMORY UNIVERSITY Targeting GPR68 as a novel modulator of osteoarthritis
KU, GREGORY MICHAEL UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Creating a mouse and human model of a novel monogenic diabetes syndrome
MA, ZHENGYU ALFRED I. DU PONT HOSP FOR CHILDREN Identify cell surface protein ligand candidates for understudied adhesion GPCRs using a sensitive cell-based approach
NAKAGAWA, TERUNAGA VANDERBILT UNIVERSITY Illuminating the structure and function of CACNG5 and 7
ORLANDI, CESARE UNIVERSITY OF ROCHESTER Orphan Receptor Gprc5b in Retinoic Acid-induced Affective Behaviors
PROBER, DAVID AARON (contact) 
CHOU, TSUI-FEN 		 CALIFORNIA INSTITUTE OF TECHNOLOGY Phosphoproteomic Analyses of Understudied Protein Kinases that affect Zebrafish Sleep
SACK, JON THOMAS (contact)
FERNS, MICHAEL J     		 UNIVERSITY OF CALIFORNIA AT DAVIS  Generation of tools for visualizing understudied KvS potassium channel proteins
SHEPARD, BLYTHE D  GEORGETOWN UNIVERSITY Hepatic GPR125: ligands and liver repair
SINGH, HARPREET OHIO STATE UNIVERSITY Biophysical properties and role of CLIC6 in cardiomyocyte mitochondria
THYME, SUMMER B UNIVERSITY OF ALABAMA AT BIRMINGHAM Role of VRK2 Kinase in Brain Development and Function
TOWLER, DWIGHT A UT SOUTHWESTERN MEDICAL CENTER Cdc42bpg signaling in arteriosclerosis and vascular fibrosis
TURK, BENJAMIN E YALE UNIVERSITY Defining protein interaction networks involving the atypical MAP kinases ERK4 and ERK7
WANG, BIAO UNIVERSITY OF CALIFORNIA, SAN FRANCISCO TSSK-dependent signaling pathway in spermatogenesis
YOUNG, SAMUEL MATTHEW UNIVERSITY OF IOWA Elucidating the roles of CACNA2D2 and CACNA2D3 in presynaptic regulation of mammalian synaptic function
YU, EUGENE  ROSWELL PARK CANCER INSTITUTE CORP CRISPR-mediated engineering and pilot study of mouse mutants of the bitter taste receptor genes
ZAGOTTA, WILLIAM N UNIVERSITY OF WASHINGTON Functional and structural dynamics of KCNH4 and KCNH8

 

Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed) RFA-RM-21-020
PI Name Institution Name Title
KANNAN, NATARAJAN (contact)
LU, WEI.		 UNIVERSITY OF GEORGIA Annotating dark ion-channel functions using evolutionary features, machine learning and knowledge graph mining
PANDEY, GAURAV (contact)
SCHLESSINGER, AVNER		 ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Multi-modal data integration to identify kinase substrates
ZHANG, BING BAYLOR COLLEGE OF MEDICINE Illuminating understudied druggable proteins using pan-cancer proteogenomics data

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-20-019
PI Name Institution Name Title
BANERJEE, PRIYA R STATE UNIVERSITY OF NEW YORK AT BUFFALO Deciphering the role of low complexity domains in dual specificity kinase function
BOBECK, ERIN NICOLE UTAH STATE UNIVERSITY GPR171 As a Novel Target to Treat Neuropathic Pain

BRETT, THOMAS JOHN

 WASHINGTON UNIVERSITY Illuminating the role of chloride channel regulator CLCA4 in TMEM16 Family potentiation and disease
CARON, KATHLEEN M UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating Orphan GPCRs in Lymphatics
CHANG, GEOFFREY A (contact) 
INSEL, PAUL A 		 UNIVERSITY OF CALIFORNIA, SAN DIEGO Nanobody inhibitors of proton-sensing G protein-coupled receptors
COLECRAFT, HENRY M COLUMBIA UNIVERSITY HEALTH SCIENCES Nanobodies for Probing CACNA2D2 and CACNA2D3 Function, Expression, and Therapeutics
GAUTRON, LAURENT UT SOUTHWESTERN MEDICAL CENTER Neuronal GPR149 and energy homeostasis
GERBER, SCOTT A DARTMOUTH COLLEGE Proteomics approaches for illuminating the functions of the dark kinases Nek6, Nek7 & Nek9
GRUETER, CHAD E UNIVERSITY OF IOWA Cdk19-dependent transcriptional mechanisms in cardiac hypertrophy
HAMMOND, GERALD R UNIVERSITY OF PITTSBURGH AT PITTSBURGH PIP5K1A as a novel driver of PI3K signaling in health and disease
KHOR, BERNARD BENAROYA RESEARCH INST AT VIRGINIA MASON  Illuminating a novel role of understudied DYRKs in anti-inflammatory T cell differentiation
LEE, SUN JOO WASHINGTON UNIVERSITY Structure/function analysis of understudied pH-sensitive Kir4.2 channels in vitro with conformation specific nanobodies
MACLEAN, DAVID MALCOM UNIVERSITY OF ROCHESTER Genetic code expansion and the study of CACNG proteins
MAIERS, JESSICA L MAYO CLINIC ROCHESTER Identifying targetable mechanisms of TMEM38B/TRIC-B in liver fibrosis
MYERS, BENJAMIN UNIVERSITY OF UTAH Illuminating Druggable Targets via Interrogation of Direct GPCR-kinase Interactions
NAIRN, ANGUS C YALE UNIVERSITY Role of MAST3 kinase in developmental and epileptic encephalopathy
PABLA, NAVJOT OHIO STATE UNIVERSITY Illuminating the biological functions of CDKL1 Kinase
REITER, JEREMY F UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Illuminating the function of the understudied kinase DYRK2 in ciliary Hedgehog signal transduction
SANTY, LORRAINE C PENNSYLVANIA STATE UNIVERSITY-UNIV PARK Identifying endosomal Phosphatidylinositol 4-phosphate 5-kinase isoforms regulating growth factor stimulated integrin recycling and migration
SUTTON, LAURIE UNIVERSITY OF MARYLAND BALT CO CAMPUS Investigating the role of GPR162 in hedonic behaviors
TRAYNELIS, STEPHEN F EMORY UNIVERSITY Genetic analysis to determine the functional role of GRID1
VARSHNEY, GAURAV K OKLAHOMA MEDICAL RESEARCH FOUNDATION Functional characterization of understudied protein kinases implicated in developmental disorders using zebrafish
WANDINGER-NESS, ANGELA (contact) 
HUDSON, LAURIE G		 UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Illuminating the functions and translational potential of CDC42BP/MRCK kinases in ovarian cancer
ZHANG, CHENG UNIVERSITY OF PITTSBURGH AT PITTSBURGH Structure and pharmacology of GPR32 in the resolution of inflammation

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-19-011
PI Name Institution Name Title
BUROW, MATTHEW E. (contact) 
DREWRY, DAVID HAROLD		 TULANE UNIVERSITY OF LOUISIANA Characterization of an understudied kinase, NEK5, in acquisition of a mesenchymal and migratory cell
FOSKETT, JAMES KEVIN UNIVERSITY OF PENNSYLVANIA Identification of CALHM proteins as ion channels

GLIMCHER, LAURIE HOLLIS

 DANA-FARBER CANCER INST Multi-faceted Roles of an Atypical Kinase RIOK2 in Erythropoiesis and Myelodyplastic Syndromes
GOETZ, SARAH DUKE UNIVERSITY Defining biochemical mechanisms of dominant interference by disease-causing variants of TTBK2
GOLKOWSKI, MARTIN UNIVERSITY OF WASHINGTON Targeting understudied kinases in cancer cell plasticity and drug resistance
HAHN, WILLIAM C DANA-FARBER CANCER INST Novel genetic dependencies in VRK2 methylated glioblastoma multiforme
JIN, CHUNYANG (contact) 
HESK, DAVID		 RESEARCH TRIANGLE INSTITUTE Preparation and characterization of radioligands for the orphan receptor GPR88
JO, YOUNG-HWAN ALBERT EINSTEIN COLLEGE OF MEDICINE Role of HCAR1 in glucose homeostasis
JURA, NATALIA UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Structural and functional investigation of the understudied HIPK1 kinase
MANGLIK, AASHISH UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Biochemical approaches to enlighten GPR85 function
MARTINELLI, DAVID CHRISTOPHER UNIVERSITY OF CONNECTICUT SCH OF MED/DNT Determination of the subcellular localization of adhesion G protein-coupled receptor B3 (ADGRB3) and its locations of interaction with secreted C1Q-like ligands 
NGUYEN, THUY RESEARCH TRIANGLE INSTITUTE Development of Novel Neuropeptide B/W Receptor 1 Agonists
PHILIPS, MARK REID NEW YORK UNIVERSITY SCHOOL OF MEDICINE Regulation of KRAS Trafficking and Signaling by GPR31
REN, HONGXIA (contact) 
WATTS, VAL J		 INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS Illuminating the Metabolic Function of GPR162 by Delineating Downstream Signaling Pathways and Characterizing Hypothalamic Expression Pattern
SODEN, MARTA E    UNIVERSITY OF WASHINGTON Targeted mutagenesis to elucidate the function of understudied ion channels in the central nervous system 
TERSEY, SARAH A. (contact) 
MIRMIRA, RAGHAVENDRA G		 UNIVERSITY OF CHICAGO The 12-HETE receptor Gpr31 in the β-cell pathogenesis of type 1 diabetes
TSAI, NIEN-PEI UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Study of PAK3 in epilepsy-associated defects in synaptic plasticity

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-18-021
PI Name Institution Name Title

ARAC-OZKAN, DEMET

 UNIVERSITY OF CHICAGO Structural and Functional Studies of Brain Angiogenesis Inhibitors (BAIs/ADGRBs)
CHAHROUR, MARIA UT SOUTHWESTERN MEDICAL CENTER Investigating the role of BCKDK in neurodevelopmental disorders through a novel mouse model

DEVI, LAKSHMI A

 ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Targeted Deorphanization of G Protein-Coupled Receptors
FESKE, STEFAN NEW YORK UNIVERSITY SCHOOL OF MEDICINE Calcium channel CACNB1 in T cell function and immunity
GREEN, THOMAS ARTHUR (contact)
LAEZZA, FERNANDA		 UNIVERSITY OF TEXAS MED BR GALVESTON Gpr12: a novel factor for addiction and mental health
ISOM, DANIEL UNIVERSITY OF MIAMI SCHOOL OF MEDICINE New CRISPR-based technologies for screening dark GPCRs
KU, GREGORY MICHAEL UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Uncovering Two Novel Diabetes Drug Targets in the IDG
LEE, AMY UNIVERSITY OF IOWA Illuminating the functions of CACNA2D4 in the brain
LODMELL, J STEPHEN UNIVERSITY OF MONTANA Role of the atypical protein kinase RIOK3 in the cellular antiviral response
MARTO, JARROD A DANA-FARBER CANCER INST Tools for the understudied kinase PNK3
NEWTON, ALEXANDRA C UNIVERSITY OF CALIFORNIA, SAN DIEGO Establishing Function of Understudied PRKCQ Kinase in Cellular Regulation and Disease
SEBAG, JULIEN ALBERT UNIVERSITY OF IOWA Identification of the central localization and regulation of the Prokineticin 1 Receptor, a novel target for the treatment of obesity
TAYLOR, SUSAN S UNIVERSITY OF CALIFORNIA, SAN DIEGO Illuminating the Role of understudied PRKACB Splice Variants in PKA Signaling
TURK, BENJAMIN E (contact)
CALDERWOOD, DAVID A		 YALE UNIVERSITY Interaction of substrates and inhibitors with tousled-like kinase 2
WHIM, MATTHEW LSU HEALTH SCIENCES CENTER Determining the role of the adrenal Y2 and Y5 receptors in the prevention of hypoglycemia
WHITEHURST, ANGELIQUE WRIGHT UT SOUTHWESTERN MEDICAL CENTER Mechanisms and Models of Testis Specific Serine Kinase 6 (TSSK6)

 

Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed) RFA-RM-18-011
PI Name Institution Name Title
KANNAN, NATARAJAN (contact)
KOCHUT, KRZYSZTOF J.		 UNIVERSITY OF GEORGIA A data analytics framework for mining the dark kinome
ROBINSON, PETER NICHOLAS (contact)
MUNGALL, CHRISTOPHER J
OPREA, TUDOR I		 JACKSON LABORATORY Illuminating the Druggable Genome by Knowledge Graphs
WU, GUANMING (contact)
DEUSTACHIO, PETER G
STEIN, LINCOLN D.		 OREGON HEALTH & SCIENCE UNIVERSITY Reactome IDG portal: Pathway-based analysis and visualization of understudied human proteins

 

Knowledge Management Center for Illuminating the Druggable Genome (U24) RFA-RM-16-024
PI Name Institution Name Title
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Knowledge Management Center for Illuminating the Druggable Genome (Component Award)
OPREA, TUDOR I UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Knowledge Management Center for Illuminating the Druggable Genome (Center Award)

 

Data and Resource Generation Centers for Illuminating the Druggable Genome (U24) RFA-RM-16-026
PI Name Institution Name Title
JOHNSON, GARY L UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating Function of the Understudied Druggable Kinome
MCMANUS, MICHAEL T (contact) 
JAN, LILY Y		 UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Illuminating Druggable Dark Matter
ROTH, BRYAN L. (contact) 
SHOICHET, BRIAN K		 UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating the druggable GPCR-ome

 

Resource Dissemination and Outreach Center for Illuminating the Druggable Genome (U24) RFA-RM-16-025
PI Name Institution Name Title
SCHÜRER, STEPHAN C (contact) 
OPREA, TUDOR I 
SKLAR, LARRY A. 		 UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)

 

Development of a Knowledge Management Center for Illuminating the Druggable GenomeTitle Here (U54) RFA-RM-13-011
PI Name Institution Name Title
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Mount Sinais Knowledge Management Center for Illuminating the Druggable Genome
OPREA, TUDOR I UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Illuminating the Druggable Genome Knowledge Management Center (IDG KMC)

 

Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01) RFA-RM-13-010
PI Name Institution Name Title

FINKBEINER, STEVEN M.

 J. DAVID GLADSTONE INSTITUTES Physical Exam of Human Neurons to Identify Functions of the Druggable Genome
JOHNSON, GARY L. UNIV OF NORTH CAROLINA CHAPEL HILL Activation and Regulation of the Understudied Kinome Using MIB/MS Technology

MCMANUS, MICHAEL T.

 UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Unlocking the Hidden Kinome
QIN, JUN BAYLOR COLLEGE OF MEDICINE Signaling Networks of Nuclear Receptor Transcriptional Crosstalk in Lung Cancer
ROTH, BRYAN L (contact)
SHOICHET, BRIAN K.		 UNIV OF NORTH CAROLINA CHAPEL HILL Scalable technologies for illuminating the druggable GPCR-ome
TOMITA, SUSUMU YALE UNIVERSITY Identify functional modulators of ionotropic neurotransmitter receptors in brain
YEH, JING-RUEY JOANNA (contact)
KOKEL, DAVID		 MASSACHUSETTS GENERAL HOSPITAL Scalable in vivo tools for annotating and manipulating the druggable genome

 

This page last reviewed on May 24, 2023