Funded Research

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-19-011
PI Name Institution Name Title
BUROW, MATTHEW E. (contact) 
DREWRY, DAVID HAROLD
TULANE UNIVERSITY OF LOUISIANA Characterization of an understudied kinase, NEK5, in acquisition of a mesenchymal and migratory cell
FOSKETT, JAMES KEVIN UNIVERSITY OF PENNSYLVANIA Identification of CALHM proteins as ion channels

GLIMCHER, LAURIE HOLLIS

DANA-FARBER CANCER INST Multi-faceted Roles of an Atypical Kinase RIOK2 in Erythropoiesis and Myelodyplastic Syndromes
GOETZ, SARAH DUKE UNIVERSITY Defining biochemical mechanisms of dominant interference by disease-causing variants of TTBK2
GOLKOWSKI, MARTIN UNIVERSITY OF WASHINGTON Targeting understudied kinases in cancer cell plasticity and drug resistance
HAHN, WILLIAM C DANA-FARBER CANCER INST Novel genetic dependencies in VRK2 methylated glioblastoma multiforme
JIN, CHUNYANG (contact) 
HESK, DAVID
RESEARCH TRIANGLE INSTITUTE Preparation and characterization of radioligands for the orphan receptor GPR88
JO, YOUNG-HWAN ALBERT EINSTEIN COLLEGE OF MEDICINE Role of HCAR1 in glucose homeostasis
JURA, NATALIA UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Structural and functional investigation of the understudied HIPK1 kinase
MANGLIK, AASHISH UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Biochemical approaches to enlighten GPR85 function
MARTINELLI, DAVID CHRISTOPHER UNIVERSITY OF CONNECTICUT SCH OF MED/DNT Determination of the subcellular localization of adhesion G protein-coupled receptor B3 (ADGRB3) and its locations of interaction with secreted C1Q-like ligands 
NGUYEN, THUY RESEARCH TRIANGLE INSTITUTE Development of Novel Neuropeptide B/W Receptor 1 Agonists
PHILIPS, MARK REID NEW YORK UNIVERSITY SCHOOL OF MEDICINE Regulation of KRAS Trafficking and Signaling by GPR31
REN, HONGXIA (contact) 
WATTS, VAL J
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS Illuminating the Metabolic Function of GPR162 by Delineating Downstream Signaling Pathways and Characterizing Hypothalamic Expression Pattern
SODEN, MARTA E    UNIVERSITY OF WASHINGTON Targeted mutagenesis to elucidate the function of understudied ion channels in the central nervous system 
TERSEY, SARAH A. (contact) 
MIRMIRA, RAGHAVENDRA G
UNIVERSITY OF CHICAGO The 12-HETE receptor Gpr31 in the β-cell pathogenesis of type 1 diabetes
TSAI, NIEN-PEI UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Study of PAK3 in epilepsy-associated defects in synaptic plasticity

 

Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed) RFA-RM-18-021
PI Name Institution Name Title

ARAC-OZKAN, DEMET

UNIVERSITY OF CHICAGO Structural and Functional Studies of Brain Angiogenesis Inhibitors (BAIs/ADGRBs)
CHAHROUR, MARIA UT SOUTHWESTERN MEDICAL CENTER Investigating the role of BCKDK in neurodevelopmental disorders through a novel mouse model

DEVI, LAKSHMI A

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Targeted Deorphanization of G Protein-Coupled Receptors
FESKE, STEFAN NEW YORK UNIVERSITY SCHOOL OF MEDICINE Calcium channel CACNB1 in T cell function and immunity
GREEN, THOMAS ARTHUR (contact)
LAEZZA, FERNANDA
UNIVERSITY OF TEXAS MED BR GALVESTON Gpr12: a novel factor for addiction and mental health
ISOM, DANIEL UNIVERSITY OF MIAMI SCHOOL OF MEDICINE New CRISPR-based technologies for screening dark GPCRs
KU, GREGORY MICHAEL UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Uncovering Two Novel Diabetes Drug Targets in the IDG
LEE, AMY UNIVERSITY OF IOWA Illuminating the functions of CACNA2D4 in the brain
LODMELL, J STEPHEN UNIVERSITY OF MONTANA Role of the atypical protein kinase RIOK3 in the cellular antiviral response
MARTO, JARROD A DANA-FARBER CANCER INST Tools for the understudied kinase PNK3
NEWTON, ALEXANDRA C UNIVERSITY OF CALIFORNIA, SAN DIEGO Establishing Function of Understudied PRKCQ Kinase in Cellular Regulation and Disease
SEBAG, JULIEN ALBERT UNIVERSITY OF IOWA Identification of the central localization and regulation of the Prokineticin 1 Receptor, a novel target for the treatment of obesity
TAYLOR, SUSAN S UNIVERSITY OF CALIFORNIA, SAN DIEGO Illuminating the Role of understudied PRKACB Splice Variants in PKA Signaling
TURK, BENJAMIN E (contact)
CALDERWOOD, DAVID A
YALE UNIVERSITY Interaction of substrates and inhibitors with tousled-like kinase 2
WHIM, MATTHEW LSU HEALTH SCIENCES CENTER Determining the role of the adrenal Y2 and Y5 receptors in the prevention of hypoglycemia
WHITEHURST, ANGELIQUE WRIGHT UT SOUTHWESTERN MEDICAL CENTER Mechanisms and Models of Testis Specific Serine Kinase 6 (TSSK6)

 

Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed) RFA-RM-18-011
PI Name Institution Name Title
KANNAN, NATARAJAN (contact)
KOCHUT, KRZYSZTOF J.
UNIVERSITY OF GEORGIA A data analytics framework for mining the dark kinome
ROBINSON, PETER NICHOLAS (contact)
MUNGALL, CHRISTOPHER J
OPREA, TUDOR I
JACKSON LABORATORY Illuminating the Druggable Genome by Knowledge Graphs
WU, GUANMING (contact)
DEUSTACHIO, PETER G
STEIN, LINCOLN D.
OREGON HEALTH & SCIENCE UNIVERSITY Reactome IDG portal: Pathway-based analysis and visualization of understudied human proteins

 

Knowledge Management Center for Illuminating the Druggable Genome (U24) RFA-RM-16-024
PI Name Institution Name Title
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Knowledge Management Center for Illuminating the Druggable Genome (Component Award)
OPREA, TUDOR I UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Knowledge Management Center for Illuminating the Druggable Genome (Center Award)

 

Data and Resource Generation Centers for Illuminating the Druggable Genome (U24) RFA-RM-16-026
PI Name Institution Name Title
JOHNSON, GARY L UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating Function of the Understudied Druggable Kinome
MCMANUS, MICHAEL T (contact) 
JAN, LILY Y
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Illuminating Druggable Dark Matter
ROTH, BRYAN L. (contact) 
SHOICHET, BRIAN K
UNIV OF NORTH CAROLINA CHAPEL HILL Illuminating the druggable GPCR-ome

 

Resource Dissemination and Outreach Center for Illuminating the Druggable Genome (U24) RFA-RM-16-025
PI Name Institution Name Title
SCHÜRER, STEPHAN C (contact) 
OPREA, TUDOR I 
SKLAR, LARRY A. 
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)

 

Development of a Knowledge Management Center for Illuminating the Druggable GenomeTitle Here (U54) RFA-RM-13-011
PI Name Institution Name Title
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Mount Sinais Knowledge Management Center for Illuminating the Druggable Genome
OPREA, TUDOR I UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Illuminating the Druggable Genome Knowledge Management Center (IDG KMC)

 

Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01) RFA-RM-13-010
PI Name Institution Name Title

FINKBEINER, STEVEN M.

J. DAVID GLADSTONE INSTITUTES Physical Exam of Human Neurons to Identify Functions of the Druggable Genome
JOHNSON, GARY L. UNIV OF NORTH CAROLINA CHAPEL HILL Activation and Regulation of the Understudied Kinome Using MIB/MS Technology

MCMANUS, MICHAEL T.

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Unlocking the Hidden Kinome
QIN, JUN BAYLOR COLLEGE OF MEDICINE Signaling Networks of Nuclear Receptor Transcriptional Crosstalk in Lung Cancer
ROTH, BRYAN L (contact)
SHOICHET, BRIAN K.
UNIV OF NORTH CAROLINA CHAPEL HILL Scalable technologies for illuminating the druggable GPCR-ome
TOMITA, SUSUMU YALE UNIVERSITY Identify functional modulators of ionotropic neurotransmitter receptors in brain
YEH, JING-RUEY JOANNA (contact)
KOKEL, DAVID
MASSACHUSETTS GENERAL HOSPITAL Scalable in vivo tools for annotating and manipulating the druggable genome

 

This page last reviewed on October 6, 2020