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Program Snapshot

The High-Risk, High-Reward Research Program has four unique funding opportunities for exceptionally creative scientists who propose highly innovative approaches to major challenges in biomedical research:



   Agenda  •  Abstracts  •  Videocasts from Day 1Day 2, and Day 3

Save the date for the 2015 High-Risk, High-Reward Research Symposium on December 7-9 at Natcher Conference Center, NIH, Bethesda, MD!

Application Information

Comparison of  High Risk-High Reward Programs

  Early Independence
New Innovator
Pioneer Award

Research Award

FY 2015 Applications Under Review Applications Under Review Applications Under Review Applications Under Review
FY 2016 Not Available

​Due October 16, 2015

Due October 9, 2015

Due October 9, 2015


Kjersti Aagaard (2007 New Innovator) was honored with the Michael E. DeBakey, M.D., Excellence in Research Award Exit Disclaimer by the Baylor College of Medicine. The award recognizes faculty members with significant scientific contributions to clinical or basic research.

Karl Deisseroth (2005 Pioneer and 2012 Transformative Researcher) receives the FNIH 2015 Lurie Prize Exit Disclaimer for his work on optogenetics. Dr. Desisseroth also received the Carnegie Mellon's Dickson Prize in Science Exit Disclaimer and the 2014 Keio Medical Science Prize Exit Disclaimer for his revolutionary work in optogenetics and his work on CLARITY, converting tissue into a gel linked to polymers that allow transparency and high-resolution optical access.
Karl Deisseroth (2005 Pioneer and 2012 Transformative Researcher) and Xiaoliang Sunney Xie (2004 and 2013 Pioneer and 2009 and 2010 Transformative Researcher) win the prestigious Albany Prize. Exit Disclaimer Dr. Desisseroth is honored for  his role in developing optogenetics. Dr. Xie is recognized for his pioneering work in single-molecule biophysical chemistry and its application to biology.
Pardis Sabeti Exit Disclaimer (2009 New Innovator) and Martin Blaser Exit Disclaimer (2010 Transformative Researcher) named in "The 100 Most Influential People" in Time magazine
Andrea Armani Exit Disclaimer (2010 New Innovator) named a Young Global Leader by the World Economic Forum
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