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Program Snapshot

The High-Risk, High-Reward Research Program has four unique funding opportunities for exceptionally creative scientists who propose highly innovative approaches to major challenges in biomedical research:



In the News

Studying Sex Differences in Biomedical Research

Sex and gender play a significant role in how health and disease differ across individuals and influence the effectiveness of prevention and treatment efforts. Learn how supplements to High-Risk, High-Reward Research program awards are enabling researchers to investigate sex differences and their impact on biomedical issues.

A Scientist Deploys Light And Sound To Reveal The Brain

Lihong Wang (2012 Pioneer & 2013 Transformative Researcher) is interviewed on NPR Exit Disclaimer discussing his work combining the strengths of two forms of energy, light and sound, into a single form of imaging called photoacoustics. Wang's ultimate goal is to use a combination of light and sound to solve the mysteries of the human brain.

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Agenda  •  Abstracts  •  Photos Exit Disclaimer  •  Videocasts from Day 1Day 2, and Day 3

Application Information

Comparison of  High Risk-High Reward Programs

  Pioneer Award New Innovator
Research Award

Early Independence

FY 2016

Due October 9, 2015


Notice of Modification to RFA-RM-13-006 (Award Budget, Biographical Sketch, & Research Strategy)

​Due October 16, 2015


Notice of Modification to RFA-RM-13-007 (Biographical Sketch & Research Strategy)

Due October 9, 2015

Funding Opportunity Anticipated this Fall


Pioneer  •  New Innovator  •  Transformative Research  •  Early Independence

Read the Press Release

Kjersti Aagaard Honored with 2015 DeBakey Research Award


Kjersti Aagaard (2007 New Innovator) was honored with the Michael E. DeBakey, M.D., Excellence in Research Award Exit Disclaimer by the Baylor College of Medicine. The award recognizes faculty members with significant scientific contributions to clinical or basic research.

Karl Deisseroth Awarded Albany Prize, Lurie Prize, Dickson Prize in Science, & Keio Medical Science Prize


Karl Deisseroth (2005 Pioneer and 2012 Transformative Researcher) receives the prestigious Albany Prize Exit Disclaimer and FNIH 2015 Lurie Prize Exit Disclaimer for his work on optogenetics. Dr. Desisseroth also received the Carnegie Mellon's Dickson Prize in Science Exit Disclaimer and the 2014 Keio Medical Science Prize Exit Disclaimer for his revolutionary work in optogenetics and his work on CLARITY, converting tissue into a gel linked to polymers that allow transparency and high-resolution optical access.

Xiaoliang Sunney Xie Wins Albany Prize


Xiaoliang Sunney Xie (2004 and 2013 Pioneer and 2009 and 2010 Transformative Researcher) wins the prestigious Albany Prize Exit Disclaimer for his pioneering work in single-molecule biophysical chemistry and its application to biology.

Pardis Sabeti & Martin Blaser Listed in "The 100 Most Influential People"


Pardis Sabeti Exit Disclaimer (2009 New Innovator) and Martin Blaser Exit Disclaimer (2010 Transformative Researcher) named in "The 100 Most Influential People" in Time magazine. Pardis Sabeti was recognized for her dangerous and crucial work during the Ebola epidemic in West Africa identifying a single animal to human transmission that was responsible for the devastating epidemic. Martin Blaser was recognized for his work warning the public on the consequences of antibiotic overuse.

Andrea Armani Named Young Global Leader by the World Economic Forum


Andrea Armani Exit Disclaimer (2010 New Innovator) named a Young Global Leader by the World Economic Forum. The competition spans all fields, including business, social science, politics, engineering, and traditional sciences. Young Global Leaders are described as the planet’s top young leaders under the age of 40, who are “bold, brave, action-oriented and entrepreneurial…[who] commit both their time and talent to make the world a better place.”

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