High-Risk, High-Reward Research Program

Funding opportunities for outstanding scientists at all career stages

The High-Risk, High-Reward Research program supports exceptionally creative scientists pursuing highly innovative research with the potential for broad impact in biomedical  or behavioral science. The program's four constituent NIH Director's awards provide a diverse set of funding opportunities.

NIH Director's Pioneer Award NIH Director's New Innovator Award NIH Director's Transformative Research Award NIH Director's Early Independence Award

Funding Opportunities

FY Pioneer Award New Innovator
Research Award
Early Independence
2019 RFA-RM-18-007
Closed September 14, 2018
Closed September 10, 2018
Closed September 21, 2018
Closed September 27, 2018

What Is the High-Risk, High-Reward Research Program? (1 minute video)

An audio-described version of this video is also available.

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This page last reviewed on January 28, 2019