Common Fund Data Use Awards

Enhancing Utility and Usage of Common Fund Data Sets

NOT-RM-19-009: Notice of Special Interest (NOSI): Availability of Administrative Supplements for Enhancing Utility and Usage of Common Fund Data Sets. 

The Common Fund has generated valuable and widely available data sets by multiple programs, containing a variety of multi-dimensional molecular and phenotypic data from several organisms including mouse and human. As various Common Fund data resources have become available, investigators frequently state that they are unaware of the data and/or of the relevance that the data may have for their research interests. In addition, some report difficulty using or exploring the data because the data portals are non-intuitive to use and/or the data are otherwise difficult to navigate.

To maximize the impact of these data, engage a broader community of end-users for wider adoption of these data sets, and obtain feedback to enhance the data portals, the Common Fund plans to support administrative supplements encouraging the use of Common Fund data sets. Supplements are intended to enable novel and compelling biological questions to be formulated and addressed, and/or to generate cross-cutting hypotheses for future research. Supplement recipients are also asked to provide feedback on utility of the Common Fund data resources.

The established Common Fund data sets listed below are well-poised for increased community use. Applicants must propose to use at least one data set from the following list, although they can propose to use other data sets as well. While integration across multiple data sets is encouraged, it is not required.

  • 4DNucleome: The 4D Nucleome Data Portal hosts data (e.g., HiC, and DNA-FISH data sets) generated by the 4DN Network and other reference nucleomics data sets, and an expanding tool set for open data processing and visualization
  • Genotype-Tissue Expression: whole genome sequence and RNA sequence data from multiple human tissues to study tissue-specific gene expression and regulation
  • Illuminating the Druggable Genome (PHAROS): integrated source containing data on understudied druggable proteins, including mRNA and protein expression data, phenotype associations, bioactivity data, drug target interactions, disease links, and functional information
  • Knockout Mouse Phenotyping Program (KOMP2): data on broad, standardized phenotyping of a genome-wide collection of mouse knockouts
  • Library of Integrated Network-based Cellular Signatures (LINCS): library of molecular signatures that describes how different types of cells respond to a variety of agents that disrupt normal cellular function
  • Metabolomics Workbench: repository for metabolomics data and metadata from studies on cells, tissues, and organisms
  • Integrated Human Microbiome Project – microbiome, epigenomic, metabolomic, and phenotypic data for 3 cohorts

Supplement budget requests cannot exceed $200,000/year direct costs exclusive of Facilities and Administrative costs on sub-awards. It is anticipated that 10-15 awards will be made, subject to availability of funds. Applications are due July 29, 2019 by 5:00 PM local time of the applicant organization.

For additional details, including application instructions and eligibility requirements, please see NOT-RM-19-009: Notice of Special Interest (NOSI): Availability of Administrative Supplements for Enhancing Utility and Usage of Common Fund Data Sets.


 

This page last reviewed on July 1, 2019