Funded Research

Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed) RFA-RM-22-007
PI Name Institution Name Title
AHMED, TAMER AHMED MANSOUR (contact)
BROWN, C TITUS		 UNIVERSITY OF CALIFORNIA AT DAVIS Data-driven search of Common Fund data sets for better discoverability and novel meta-analysis
AY, FERHAT LA JOLLA INSTITUTE FOR IMMUNOLOGY Using Common Fund datasets for prioritization of disease-associated genetic variants
DAHMANE, NADIA (contact)
POLLARD, KATHERINE S
RESNICK, ADAM CAIN		 WEILL MEDICAL COLL OF CORNELL UNIV Deciphering the 3D genome of pediatric brain tumors

DORRESTEIN, PIETER C (contact)
WANG, MINGXUN

 UNIVERSITY OF CALIFORNIA, SAN DIEGO Cross Repository Metabolomics Data and Workflow Integration
EDWARDS, NATHAN J GEORGETOWN UNIVERSITY Functional Annotation of Glycan Motifs using Common-Fund Data Resources
FIEHN, OLIVER UNIVERSITY OF CALIFORNIA AT DAVIS Integrating metagenomics data into accurate mass stool metabolite identifications
LI, HU MAYO CLINIC ROCHESTER Uncovering therapeutic-associated biomarkers via machine learning and feature engineering approaches
LIU, JIE UNIVERSITY OF MICHIGAN AT ANN ARBOR Allele-specific analysis of human epigenome, transcriptome and high-resolution chromatin organization
WANG, JIEBIAO (contact)
YAN, QI		 UNIVERSITY OF PITTSBURGH AT PITTSBURGH Integration of GTEx and HuBMAP data to gain population-level cell-type-specific insights
ZHOU, CHAN UNIV OF MASSACHUSETTS MED SCH WORCESTER Integrative analysis of multi-omics data to identify and characterize long noncoding RNA-derived fusions in pediatric cancer

 

Engaging Common Fund Data Coordinating Centers to Establish the Common Fund Data Ecosystem (CFDE) (OT2) OTA-20-005
PI Name Institution Name Title
ARDLIE, KRISTIN BROAD INSTITUTE, INC. GTEx engagement with the CFDE-CC and other DCCs towards building a data ecosystem spanning the Common Fund projects
BLOOD, PHILIP D (contact)
BORNER, KATY
SILVERSTEIN, JONATHAN C.		 CARNEGIE-MELLON UNIVERSITY Amplifying the Value of HuBMAP Data Through Data Interoperability and Collaboration
HUNTER, PETER JOHN (contact)
DE BONO, BERNARD		 UNIVERSITY OF AUCKLAND Cross-CFDE semantic and spatial interoperability for anatomy
MA'AYAN, AVI ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI The LINCS DCIC Engagement Plan with the CFDE
MARTONE, MARYANN E (contact) 
DE BONO, BERNARD    		 UNIVERSITY OF CALIFORNIA, SAN DIEGO SPARC Engagement Plan with the Common Fund Data Ecosystem
MAZUMDER, RAJA GEORGE WASHINGTON UNIVERSITY Harmonization of GlyGen glycoconjugate and glycan array data for integration into CFDE
MILOSAVLJEVIC, ALEKSANDAR BAYLOR COLLEGE OF MEDICINE GENOMIC INDEXING OF COMMON FUND DATASETS
OPREA, TUDOR I (contact)
MA'AYAN, AVI		 UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE
PARK, PETER J HARVARD MEDICAL SCHOOL Interoperability and Collaboration with the Common Fund Data Ecosystem to Improve Utility of 4DN Data
RESNICK, ADAM CAIN (contact)
DIGIOVANNA, JACK
FERRETTI, VINCENT
HEATH, ALLISON		 CHILDREN'S HOSP OF PHILADELPHIA Kids First Data Resource Center (KFDRC): Harnessing Data-Driven Opportunities in the Present on behalf of the Future of Common Fund Data Ecosystem (CFDE)
SUBRAMANIAM, SHANKAR UNIVERSITY OF CALIFORNIA, SAN DIEGO Biomedical Data Commons Workbench (BDCW)

 

Common Fund Data Ecosystem- Coordinating Center
PI Name Institution Name Title
WHITE, OWEN UNIVERSITY OF MARYLAND BALTIMORE University of Maryland NIH Data Commons Facilitation Center

 

Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed) RFA-RM-21-007
PI Name Institution Name Title
CAREY, VINCENT JAMES   BRIGHAM AND WOMEN'S HOSPITAL Durable Common Fund Data Interfaces and Tutorials with Bioconductor
CIESLIK, MARCIN PIOTR UNIVERSITY OF MICHIGAN AT ANN ARBOR Unraveling the topological architecture and phenotypic contexture of structural variation

KIDD, JEFFREY M

 UNIVERSITY OF MICHIGAN AT ANN ARBOR Incorporating Analysis of Gene Paralog Variation Into Existing Genomics Datasets
KRUG, KARSTEN (contact)
MANI, DENKANIKOTA R		 BROAD INSTITUTE, INC Using phosphorylation signatures of drug perturbagens to identify exercise-mimetic compounds
LAU, EDWARD UNIVERSITY OF COLORADO DENVER Investigating systems physiology with multi-omics data
LIANG, JIE UNIVERSITY OF ILLINOIS AT CHICAGO Constructing High-Resolution Ensemble Models of 3D Single-Cell Chromatin Conformations of eQTL Loci from Integrated Analysis of 4DN-GTEx Data towards Structural Basis of Differential Gene Expression
LIU, DAJIANG PENNSYLVANIA STATE UNIV HERSHEY MED CTR Methods to maximize the utility of common fund functional genomic data in multi-ethnic genetic studies
MAGA, ALI MURAT SEATTLE CHILDREN'S HOSPITAL Deep Phenotyping of 3D Data for Candidate Gene Selection from Kids First Studies
MOSHIRI, ALA UNIVERSITY OF CALIFORNIA AT DAVIS Interrogation and Interpretation of Common Fund Data Sets to Identify Novel Ocular Disease Genes
SIRIMULLA, SUMAN UNIVERSITY OF TEXAS EL PASO Using Common Fund datasets for xenobiotic localization
XU, JINRUI YALE UNIVERSITY Using three-dimensional genome structure to refine eQTL detection

 

Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed) RFA-RM-19-012
PI Name Institution Name Title
BROWN, C TITUS  UNIVERSITY OF CALIFORNIA AT DAVIS Large-scale annotation-free disease correlation analysis of the iHMP
HASSOUN, SOHA TUFTS UNIVERSITY MEDFORD Using machine learning techniques to characterize the Metabolomics Workbench Dataset

KIDD, JEFFREY M

 UNIVERSITY OF MICHIGAN AT ANN ARBOR Incorporating Analysis of Gene Paralog Variation Into Existing Genomics Datasets
LASSEIGNE, BRITTANY NICOLE UNIVERSITY OF ALABAMA AT BIRMINGHAM Using Common Fund data to inform rare disease preclinical models and prioritize drug repurposing
LIU, JIE UNIVERSITY OF MICHIGAN AT ANN ARBOR A database for high-resolution chromatin contact maps and human genetic variants
MOSELEY, HUNTER NATHANIEL UNIVERSITY OF KENTUCKY Improving Deposition Quality and FAIRness of Metabolomics Workbench
SOEMEDI, RACHEL (contact)
SOFER, TAMAR		 BROWN UNIVERSITY Using GTEx to assess the functionality of sex-biased variants
TAYLOR, DEANNE MARIE CHILDREN'S HOSP OF PHILADELPHIA Leveraging Common Fund data for feature selection in Kids First studies.
WENG, ZHIPING UNIV OF MASSACHUSETTS MED SCH WORCESTER Constructing multi-omics regulatory networks for functional variant annotation
WORLEY, KIM C BAYLOR COLLEGE OF MEDICINE Expanding the List of Human Disease Genes Using the Knockout Mouse Phenotyping Program (KOMP2) Data to Reassess Human Clinical Data
ZHAO, HONGYU YALE UNIVERSITY Computational Methods to Integrate Common Fund Data for Drug Repurposing
 ZHU, JINGCHUN UNIVERSITY OF CALIFORNIA SANTA CRUZ Use UCSC Xena to promote integration and usage of the KidsFirst, GTEx, and LINCS L1000 data sets

 

Notice of Special Interest (NOSI): Availability of Administrative Supplements for Enhancing Utility and Usage of Common Fund Data Sets (NOT-RM-19-009)

  • Hugo Bellen (Baylor College of Medicine, 3U54NS093793-05S1)- This supplement will build upon Dr. Bellen’s current work on the Model Organism Aggregated Resources for Rare Variant ExpLoration (MARRVEL) by adding data from the Knockout Mouse Phenotyping (KOMP2) and Illuminating the Druggable Genome (IDG) programs. MARRVEL is a web-based tool that provides information from both humans and various animal models on genetic variations that occur in different diseases. By adding additional Common Fund datasets to the MARRVEL tool, Dr. Bellen will create a resource that not only expands our ability to search for potential drivers of disease, but also allows for research into potential drugs that may help treat these illnesses.
     
  • Stephen Burley (Rutgers University, 3R01GM133198-01S1) – This supplement proposes to integrate the Protein Data Bank, a large, open-access resource for information on protein structures, with five Common Fund data sets (4D Nucleome, Genotype-Tissue Expression (GTEx), PHAROS (Illuminating the Druggable Genome), Metabolomics, and Knockout Mouse Phenotyping Program (KOMP2)). The proposed integration will enhance the utility of the Common Fund data sets by providing users access to protein structure information that had not previously been connected to the Common Fund data. Ultimately, this integration is expected to enable investigation of novel biological questions, and promote a more complete understanding of human health and disease.
     
  • Robert Cornell (University of Iowa, 3R01AR062547-04S1) – This supplement will leverage data from several Common Fund data sets to explore how genes are regulated during melanocyte stem cell generation and maintenance. Melanocyte stem cells play a role in skin and hair pigmentation and are involved in several different skin disorders, including melanoma. This project proposes to integrate Knockout Mouse Phenotyping Program (KOMP2) data on mice with pigmentation defects, 4D Nucleome data from melanoma cell lines, and Genotype-Tissue Expression (GTEx) data on the relationship between gene variants and gene expression levels of melanocyte-related genes. Working across these data sets will lead to a better understanding of the complex regulation of melanocytes and melanoma.
     
  • Trey Ideker and Nevan Krogan (University of California San Diego, 3U54CA209891-03S1) – This supplement aims to use data sets from the Library of Integrated Network-based Cellular Signatures and PHAROS (Illuminating the Druggable Genome) to develop artificial intelligence techniques to design novel molecules predicted to inhibit cancer protein targets. Molecules identified through this supplement would then be generated and tested in future research in cancer cell lines with genetic changes that are similar to those seen in patients. This research could be a first step towards developing a new approach to designing potent cancer treatments using artificial intelligence.
     
  • Jeffrey O’Connell (University of Maryland Baltimore, 3U01HL137181-03S1) - This supplement will use data from three Common Fund Datasets including the Genotype-Tissue Expression (GTEx), the Knockout Mouse Phenotyping (KOMP2), and the Library of Integrated Network-based Cellular Signatures (LINCS) programs. These datasets will be integrated into the web-based “Omics Analysis, Search, and Information System” (OASIS) to provide automated integration of Common Fund datasets with end-user generated association results. This new capability will automatically search and highlight connections between a multitude of datasets, all with very different types of biomedical information such as genomics, metabolomics, and proteomics. Researchers with a variety of specialties (e.g. Biologists, Epidemiologists, Physicians, Clinicians) will be exposed to the power of existing Common Fund data sets and will benefit from the automated integration provided by OASIS.
     
  • Douglas Phanstiel (University of North Carolina at Chapel Hill, 3R35GM128645-02S1) – This supplement aims to use data from the 4D Nucleome program to develop computational tools to predict pairs of genes and enhancers, which are regulatory segments of DNA that help control when genes are turned on or off. Enhancers may be located far away from the genes they regulate, making it challenging to identify which genes are the targets of a given enhancer. However, 4D Nucleome time-course data on the temporal patterns of enhancer strength, structural conformation of genetic material and associated proteins, and gene expression will be used to develop new computational approaches to predict these gene-enhancer pairs, leading to a better understanding of how genes are regulated over time.
     
  • Pinaki Sarder (State University of New York at Buffalo, 3R01DK114485-02S1) – This supplement will use kidney tissue samples collected as part of the Genotype-Tissue Expression (GTEx) program to help develop a computational image analysis method for improved diagnosis of diabetic nephropathy. The large number of healthy kidney tissue samples available through GTEx will add to the samples already collected by Dr. Sarder, improving the computational method and leading to better diagnosis and projection of disease trajectory in patients with diabetic neuropathy.
     
  • Edwin Silverman (Brigham and Women’s Hospital, 3U01HL089856-13S1) - This supplement will combine information from the Genotype-Tissue Expression (GTEx) and Illuminating the Druggable Genome (IDG) programs to deepen our understanding of chronic obstructive pulmonary disease (COPD), which is the third leading cause of death in the developed world. By using the genetic information present in the GTEX dataset, Dr. Silverman aims to identify new genetic changes that may be linked to COPD. Using this information, the study will then look for new potential drugs to help treat COPD by searching the IDG database Pharos.
     
  • Ansley Stanfill (University of Tennessee Health Science Center, 3R01NR017407-02S1) – This supplement will build upon Dr. Stanfill’s current study of aneurysmal subarachnoid hemorrhage (aSAH) in Caucasian and African American cohorts. Genotype-Tissue Expression (GTEx) data will be used to examine the effects of identified genetic variants on brain tissue gene expression in neurotransmitter pathways that are predictive of disability following aSAH. These data may provide insight into the observed disparities in outcomes after aSAH between Caucasians and African Americans. Additionally, GTEx data will be used to explore whether similar gene expression changes are present in the blood, potentially identifying a surrogate marker for brain gene expression that could inform personalized treatment interventions.

This page last reviewed on December 5, 2022