Funded Research

The Molecular Libraries and Imaging program has transitioned from Common Fund support. For more information, please visit https://commonfund.nih.gov/molecularlibraries/index. Please note that since the Molecular Libraries and Imaging program is no longer supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis.

Molecular Libraries Screening Centers and Small Molecule Repository

**Molecular Libraries Probe Production Centers Network (MLPCN) (U54) – Limited Competition**
**RFA-RM-08-005**
PI Name	Institution Name	Title
AUBE, JEFFREY	UNIVERSITY OF KANSAS	University of Kansas Specialized Chemistry Center
JACKSON, MICHAEL	SANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Burnham Center for Chemical Genomics
JONSSON, COLLEEN	SOUTHERN RESEARCH INSTITUTE	Southern Research Specialized Biocontainment Screening Center (SRSBSC)
LI, MIN	JOHNS HOPKINS UNIVERSITY	Johns Hopkins Ion Channel Center
LINDSLEY, CRAIG	VANDERBILT UNIVERSITY	The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development
ROSEN, HUGH	THE SCRIPPS RESEARCH INSTITUTE	The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps
SCHREIBER, STUART	BROAD INSTITUTE	Broad Institute Comprehensive Screening Center
SIMEONOV, ANTON	NCATS	NIH Chemical Genomics Center
SKLAR, LARRY	UNIVERSITY OF NEW MEXICO	University of New Mexico Center for Molecular Discovery

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**Molecular Libraries Screening Centers Network (MLSCN)#**
**RFA-RM-04-017**
PI Name	Institution Name	Title
AUSTIN, CHRIS	U.S. NATIONAL HUMAN GENOME RESEARCH INST	NIH Chemical Genomics Center (NCGC) Additional Information
DIAMOND, SCOTT	UNIVERSITY OF PENNSYLVANIA	The Penn Center for Molecular Discovery Additional Information
DINGLEDINE, RAYMOND	EMORY UNIVERSITY	Emory Chemistry-Biology Center in the MLSCN
LAZO, JOHN	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	University of Pittsburgh Molecular Libraries Screening Center
PIAZZA, GARY	SOUTHERN RESEARCH INSTITUTE	Southern Research Molecular Libraries Screening Center
REED, JOHN	THE BURNHAM INSTITUTE	San Diego Center for Chemical Genomics
ROSEN, HUGH	THE SCRIPPS RESEARCH INSTITUTE	Scripps Research Institute Molecular Screen Center(RMI)
ROTHMAN, JAMES	COLUMBIA UNIVERSITY MEDICAL CENTER	MLSCN Center at Columbia University
SKLAR, LARRY	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	New Mexico Molecular Libraries Screening Center Additional Information
WEAVER, C. DAVID	VANDERBILT UNIVERSITY	Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters Additional Information
Special Terms and Conditions of Roles and Responsibilities Standard to Each Screening Center (PDF, 6 pages)

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**CONTRACTS**
PI Name	Institution Name	Title
LIVINGSTON, DOUG	BIOFOCUS DPI, A GALAPAGOS COMPANY	Molecular Libraries Small Molecule Repository

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**Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03)**
**PAR-09-129**
PI Name	Institution Name	Title
ADHIKARI, SANJAY	GEORGETOWN UNIVERSITY	Screening of inhibitors for human 5-prime-tyrosyl DNA phosphodiesterase (hTDP2)
ALDRICH, COURTNEY C	UNIVERSITY OF MINNESOTA TWIN CITIES	A fluorescence displacement assay for BioA: An enzyme involved in biotin biosynthesis
ALTSHULER, DAVID	MASSACHUSETTS GENERAL HOSPITAL	Identifying the Molecular Pathways Regulating Glucose-dependent Insulin Secretion
ARNER, ELIAS S.J.	KAROLINSKA INSTITUTE	HTS FOR DRUGS TARGETING THE MAMMALIAN SELENOPROTEIN THIOREDOXIN REDUCTASE 1
ARNOLD, ALEXANDER	UNIVERSITY OF WISCONSIN MILWAUKEE	Small molecule inhibitors of the vitamin D receptor-coactivator interaction
ATKINS, JOHN F.	UNIVERSITY OF UTAH	High Throughput Screening for Foot and Mouth Disease Virus Antivirals
BARAK, LAWRENCE S.	DUKE UNIVERSITY	Small Molecule Agonsists for the Neurotensin 1 Receptor
BARROW, JAMES (contact) FERRER, MARC WEINBERGER, DANIEL	LIEBER INSTITUTE, INC.	High Throughput Screening for Specific Inhibitors and Modulators of A Novel Potas
BASSLER, BONNIE L	PRINCETON UNIVERSITY	A High-Throughput Screen for Modulators of Quorum Sensing in Vibrio cholerae
BERTHELSEN, JENS	UNIVERSITY OF COPENHAGEN	Small-molecule inhibitors of hADAM12
BISHAI, WILLIAM RAMSES	JOHNS HOPKINS UNIVERSITY	Screen for Synthetic lethality in Mycobacterium Tuberculosis
BISWAL, SHYAM	JOHNS HOPKINS UNIVERSITY	Development of inlammasome inhibitors to be used as anti-inflammatory agents
BOTTINI, NUNZIO	LA JOLLA INST FOR ALLERGY & IMMUNOLGY	Small molecule inhibitors of LMPTP: an obesity drug target
BROSH, ROBERT M (contact) BOHR, VILHELM A	U.S. NATIONAL INSTITUTE ON AGING	High Throughput Screening to Identify Inhibitors of the WRN Syndrome Helicase
CANNON, RICHARD D	UNIVERSITY OF OTAGO	Identification of Broad-spectrum Antifungal Efflux Pump Inhibitors
CAULFIELD, MICHAEL J	INTERNATIONAL AIDS VACCINE INITIATIVE	Screening for HIV-1 envelope mimetics from small molecule libraries
CHEN, JAMES K	STANFORD UNIVERSITY	A high-throughput screen for small-molecule antagonists of Gli function
CHUNG,DONGHOON	UNIVERSITY OF LOUISVILLE	A Cell-based HTS to discover molecules that inhibit VEEV, encephalitic alphavirus
CLARK, RACHAEL ANN	BRIGHAM AND WOMEN'S HOSPITAL	Identification of agents that induce E-selectin on human endothelial cells
CONNOR, JOHN H	BOSTON UNIVERSITY MEDICAL CAMPUS	Stage-Specific Inhibitors of Orthopoxviruses
CONTESSA, JOSEPH N	YALE UNIVERSITY	A bioluminescent screen for inhibitors of N-linked glycosylation
CRABTREE, GERALD R	STANFORD UNIVERSITY	Screen for Small Molecule Inhibitors of ATP Dependent Chromatin Remodeling
DALLMANN, H. GARRY	UNIVERSITY OF COLORADO AT BOULDER	Screening for Inhibitors of DNA Replication in Gram-Positive Bacteria
DANG, LENNY	AGIOS PHARMACEUTICALS, INC.	HTS for inhibitors of IDH1m & synthetic-lethal in tumor cells producing 2HG
DAUGHERTY, PATRICK S	UNIVERSITY OF CALIFORNIA SANTA BARBARA	Serine protease zymogen activation by small molecules
DAVEY, ROBERT A	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	HTS for Filo- and Arena-virus Entry Mechanisms
DESHAIES, RAYMOND J	CALIFORNIA INSTITUTE OF TECHNOLOGY	HTS for Rpn11 chemical probes
DISNEY, MATTHEW D	SCRIPPS FLORIDA	HTS to Identify Small Molecules Targeting Repeating Transcripts
DONG, XINZHONG	JOHNS HOPKINS UNIVERSITY	A screen for small molecule modulators of human GPCR MrgX1
ERKINE, ALEXANDRE M.	BUTLER UNIVERSITY	Selective Inhibitors of Human HSF2
FISHER, PAUL B	VIRGINIA COMMONWEALTH UNIVERSITY	Screening strategy for small molecules inhibitors of cancer
FLAUMENHAFT, ROBERT C	BETH ISRAEL DEACONESS MEDICAL CENTER	Identification of small molecule inhibitors of protein disulfide isomerase
FLETTERICK, ROBERT J	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Screening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells
FORTE, MICHAEL A (contact) BOURDETTE, DENNIS NEIL	OREGON HEALTH AND SCIENCE UNIVERSITY	Small Molecules Targeting the Mitochondrial Permeability Transition
FREED, ERIC	NATIONAL CANCER INSTITUTE	Discovery of lead compounds that inhibit HIV-1 budding by blocking the interaction
FRIZZELL, RAYMOND A	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Trans-NIH Research Support
FRYDMAN, JUDITH	STANFORD UNIVERSITY	High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity
GEHRING, KALLE	MCGILL UNIVERSITY	HTS Screening for small-molecule inhibitors of microRNA-mediated mRNA deadenylati
GEISS, BRIAN	COLORADO STATE UNIVERSITY-FORT COLLINS	A High-Throughput Assay for Probes of the Flavivirus RNA Guanylyltransferase
GERSHENGORN, MARVIN C	U.S. NATIONAL INST DIABETES/DIGST/KIDNEY	High Throughput Screening for Biased Agonists of the TSH Receptor that Activate t
GERSHENGORN, MARVIN C	U.S. NATIONAL INST DIABETES/DIGST/KIDNEY	Quantitative High-Throughput Screening for Small Molecule Antagonists of Human TSHR
GERSHENGORN, MARVIN C	U.S. NATIONAL INST DIABETES/DIGST/KIDNEY	qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor
GLIMCHER, LAURIE HOLLIS	HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)	Schnurri-3 Inhibitors: specific inducers of adult bone formation
GOLUBKOV, VLADISLAV	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	A High Content Screen to Identify Inhibitors of MT1-MMP Activation
GOTTESMAN, MICHAEL (contact) HALL, MATTHEW DAVID SIMEONOV, ANTON MOMTCHILOV KOPIN, ALAN S	NATIONAL CANCER INSTITUTE	A high-throughput screen for MDR1-selective chemotherapeutics
GOULD, ROBERT	BROAD INSTITUTE, INC.	Screen for Inhibitors of STK-33 Kinase Activity
GRAVES, STEVEN W	UNIVERSITY OF NEW MEXICO	High-throughput multiplex microsphere screening for toxin protease inhibitors
GRIMALDI, MAURIZIO	SOUTHERN RESEARCH INSTITUTE	A fully validated assay to identify activators of ERSR in human glioma cells: identification of small molecules with potential gliotoxic activity
HAHN, WILLIAM C	DANA-FARBER CANCER INSTITUTE	Discovering modulators of PAX8 for targeting ovarian cancer
HALDAR, KASTURI (contact) ZHENG, WEI	UNIVERSITY OF NOTRE DAME	Malaria Phosphatase Inhibitors Identified as a Potential New Malaria Treatment
HARDY, JEANNE ANN	UNIVERSITY OF MASSACHUSETTS AMHERST	Caspase-6 allosteric inhibitors: activity probes and neurodegeneration treatment
HARLAN-WILLIAMS, LISA M	UNIVERSITY OF KANSAS MEDICAL CENTER	HTS Assay to Identify Small Molecule Activators of BRCA1 Expression
HARRIS, REUBEN S	UNIVERSITY OF MINNESOTA TWIN CITIES	APOBEC3G DNA Deaminase Inhibitor High Throughput Screen
HERZBERG, OSNAT	UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS	Compound library screening using Giardia labmblia high throughput viability assay
HU, LONGQIN	RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK	HTS fluorescence polarization assay for inhibitors of Keap1-Nrf2 interaction
IADAROLA, MICHAEL J	U.S. NAT'L INST/DENTAL/CRANIOFACIAL RES	HTS for Identifying Allosteric Modulators of TRPV1 receptor
IMPERIALI, BARBARA	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Inhibition of Glycoprotein Biosynthesis in Gram-Negative Pathogens
INIGUEZ LLUHI, JORGE A	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Chemical probes targeting the SUMO protease SENP1 in Prostate Cancer
IOANNOU, YIANNIS A	MOUNT SINAI SCHOOL OF MEDICINE OF NYU	HTS of NPC1 promoter activators
IOANNOU, YIANNIS A	MOUNT SINAI SCHOOL OF MEDICINE OF NYU	HTS of Rab9 Promoter Activators
JACOBSON, DAVID AARON	VANDERBILT UNIVERSITY	Small molecule modulators of the two-pore-domain potassium channel, TREK-2
JANZEN, WILLIAM PERRY	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	High-Throughput Screening for the Discovery of Novel Scaffolds that Antagonize Methylated Histone Recognition
JARVIK, JONATHAN W	CARNEGIE-MELLON UNIVERSITY	HTS FOR NON-CANONICAL LIGANDS FOR BETA 2 ADRENERGIC RECEPTOR INTERNALIZATION
JENKINSON, SARAH RHIANNON (contact); CHEN, CATHERINE; HODES, RICHARD JOEL	NATIONAL CANCER INSTITUTE	Identification of small molecule activator of co-stimulatory pathways for T cell
JENNINGS, PATRICIA A	UNIVERSITY OF CALIFORNIA SAN DIEGO	HTS for Modulators of MitoNEET Proteins' Function
JONSSON, COLLEEN B	UNIVERSITY OF LOUISVILLE	Discovery of Small Molecule Probes for Influenza NS1A
KAUFMAN, RANDAL J	UNIVERSITY OF MICHIGAN AT ANN ARBOR	HTP chemical genomic screens to identify positive regulators of the Unfolded Protein Response
KIM, HEE-YONG	U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM	High Throughput Screening (HTS) for Akt/mTORC2: Identification of Novel Inhibitor
KITSIS, RICHARD N	ALBERT EINSTEIN COL OF MED YESHIVA UNIV	High-Throughput Screen for Small Molecules that Modulate Myocardial Damage
KOH, MEI YEE	UNIVERSITY OF TEXAS MD ANDERSON CAN CTR	High-throughput screen for specific small-molecule inhibitors of HIF-2A activity
KOPIN, ALAN S	TUFTS MEDICAL CENTER	Bursicon Receptor Antagonists: Templates for Developing Novel Insecticides
KRISHNAMURTHY, PARTHA C	UNIVERSITY OF KANSAS MEDICAL CENTER	High Throughput Screening for Inhibitors of the ABC Transporter ABCB6
KUNG, ANDREW L (contact) STEGMAIER, KIMBERLY	DANA-FARBER CANCER INSTITUTE	Targeting the ETS Transcription Factor Rearrangement EWS/FLI in Ewing's Sarcoma
LANDER, ERIC S	BROAD INSTITUTE, INC.	High-throughput screening for small molecules with specific toxicity for breast cancer stem cells
LASMEZAS, CORINNE IDA	SCRIPPS FLORIDA	High Throughput Screening for compounds reducing cell surface prion protein
LEE, JEANNIE T	MASSACHUSETTS GENERAL HOSPITAL	HTS of Gamma Glutamyl Transpeptidase for the Discovery of Novel Antimicrobials
LIANG, T. JAKE (contact) ZHENG, WEI	U.S. NATIONAL INST DIABETES/DIGST/KIDNEY	Quantitative High Throughput Screen to Identify Novel Antivirals against Hepatiti
LIEBER, MICHAEL R	UNIVERSITY OF SOUTHERN CALIFORNIA	Selective Inhibitors of the Artemis Endonuclease
LINDQUIST, SUSAN L.	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Identification of malaria Hsp40 chaperone inhibitors in yeast
LINDQUIST, SUSAN L.	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Identification of compounds that reverse cellular toxicity of A beta peptide in a
LLOYD, R STEPHEN	OREGON HEALTH AND SCIENCE UNIVERSITY	Inhibitors of DNA polymerase kappa
LORSCH, JON R	JOHNS HOPKINS UNIVERSITY	Modulators of the fidelity of start codon recognition in eukaryotes
LU, KUN PING	BETH ISRAEL DEACONESS MEDICAL CENTER	Identification of Pin1 Chemical Probes for Studying Phosphorylation Signaling
MAEGAWA, GUSTAVO HENRIQUE BOFF	JOHNS HOPKINS UNIVERSITY	A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase
MAHLEY, ROBERT W.	J. DAVID GLADSTONE INSTITUTES	ApoE4 Structure Correctors as a Therapeutic Approach for Alzheimers Disease
MANKIN, ALEXANDER S (contact) ORELLE, CEDRIC	UNIVERSITY OF ILLINOIS AT CHICAGO	Inhibitors of Bacterial Protein Synthesis with Novel Modes of Action
MARCHAND, CHRISTOPHE	NATIONAL CANCER INSTITUTE	Quantitative High-throughput Discovery of Human Tyrosyl-DNA Phosphodiesterase I (Tdp1) Inhibitors
MARUGAN, JUAN J (contact) FERRER, MARC OLEFSKY, JERROLD MICHAEL	U.S. NATIONAL HUMAN GENOME RESEARCH INST	Identification of GPR120 B-arrestin-2 Biased Agonists for the Treatment of Insuli
MAURIZI, MICHAEL ROBERT	NATIONAL CANCER INSTITUTE	High throughput screen to identify activators of Bacillus subtilis ClpP with anti
MAZIN, ALEXANDER V	DREXEL UNIVERSITY	Development of RAD52 inhibitors to induce synthetic lethality of BRCA2-deficient
MAZIN, ALEXANDER V	DREXEL UNIVERSITY	Identification of inhibitors of RAD54, an important DNA repair protein
MINOND, DMITRIY	TORREY PINES INST FOR MOLECULAR STUDIES	HTS Assays to Discover Selective Inhibitors of ADAM10 and 17
MOWEN, KERRI A	SCRIPPS RESEARCH INSTITUTE	An Activity-Based Assay to Screen for PRMT1 Inhibitors
NELSON, WILLIAM GEORGE	JOHNS HOPKINS UNIVERSITY	Screen for Small Molecule Antagonists of MBD2
NEUBIG, RICHARD R	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Cell-based Screen for RGS Modulators
OSTERMAN, ANDREI L	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	Inhibitors of Staphylococcus aureus NaMN adenylyltransferase NadD
PARRA, KARLETT J	UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR	Flow Cytometry HTS of Small Molecules that Regulate V-ATPase Proton Transport
PATHAK, VINAY K.	NATIONAL CANCER INSTITUTE	Identification of Small Molecule Inhibitors of Vif-A3G and Vif-A3F Interactions as Novel Antiviral Agents for Treatment of HIV-1 Infection
PEGAN, SCOTT DUSAN	UNIVERSITY OF DENVER (COLORADO SEMINARY)	Molecular probes for a vOTU from CCHFV using a fluorogenic peptide
PETROSKI, MATTHEW	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	High throughput screening for modulators of UBC12
POMMIER, YVES	NATIONAL CANCER INSTITUTE	Identification of human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) repair inhibitors
PRELICH, GREGORY	YESHIVA UNIVERSITY	A High-throughput in Vivo Screen for Small Molecule Inhibitors of SUMOylation
PROSSNITZ, ERIC R	UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR	MLP Assay for Arrestin-AP2 Inhibitors
PUIGSERVER, PERE	DANA-FARBER CANCER INSTITUTE	HTS of Compounds Modulating PGC-1a Acetylation and Oxidative Metabolic Function
REDDY, SITA (contact) NEAMATI, NOURI	UNIVERSITY OF SOUTHERN CALIFORNIA	High Throughput Screen for Myotonic Dystrophy Type 1
RICKERT, ROBERT C	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE	Functional Antagonists of EBI12/GPR183 as chemical probes for inflammation
ROTH, GREGORY PAUL	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE	Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis
RUOSLAHTI, ERKKI	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	High-throughput screen to identify modulators of CendR-mediated cellular uptake
SABATINI, DAVID M.	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Inhibitors of serine biosynthesis
SALVESEN, GUY S	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	Selective Allosteric Inhibitors of SENP8
SASAKI, ATSUO	BETH ISRAEL DEACONESS MEDICAL CENTER	Chemical probes that modulate a stress pathway phosphatidylinositol 5-phosphate 4
SHAMJI, ALYKHAN	BROAD INSTITUTE, INC.	Development of Small-Molecule Probes of the Histone Methyltransferase NSD2
SHEWMAKER, FRANK P	HENRY M. JACKSON FDN FOR THE ADV MIL/MED	Molecular library screen for suppressors of FUS proteinopathy
SIBLEY, DAVID R.	U.S. NATIONAL INST/NEURO/DS/STROKE	Discovery of Novel Allosteric Modulators of the D3 Dopamine Receptor
SIDEROVSKI, DAVID P	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Enzymatic Screen for RGS Protein Modulators
SLUSHER, BARBARA STAUCH	JOHNS HOPKINS UNIVERSITY	HTS Screening for Glutaminase Inhibitors
SODROSKI, JOSEPH G	DANA-FARBER CANCER INSTITUTE	Broad-range Inhibitors of Human Immunodeficiency Virus Entry
STAMM, STEFAN	UNIVERSITY OF KENTUCKY	Identification of substances that change alternative pre-mRNA splicing of the serotonin 2C receptor
STANLEY, JOHN R	UNIVERSITY OF PENNSYLVANIA	High throughput screening to find inhibitors of pathogenic pemphigus antibodies
STERN, LAWRENCE J	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Small molecule probes of ERAP-1
SYKES, DAVID B	MASSACHUSETTS GENERAL HOSPITAL	Discovering small molecules that overcome differentiation arrest in acute myeloid
TAUTZ, LUTZ	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	STEP inhibitors for intervention in Alzheimer's Disease
TESMER, JOHN J G	UNIVERSITY OF MICHIGAN AT ANN ARBOR	RNA Aptamer-Based Screen for Selective Inhibitors of GRK2
TORTORELLA, DOMENICO	MOUNT SINAI SCHOOL OF MEDICINE OF NYU	Identification of Inhibitors that Stabilize ER Degradation Substrates
TORTORELLA, DOMENICO	MOUNT SINAI SCHOOL OF MEDICINE	Identification of novel inhibitors targeting entry of human cytomegalovirus
UMEMORI, HISASHI	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy
VUORI, KRISTIINA	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	HTS for Caspase-8 selective TRAIL Sensitizers
WAHL, GEOFFREY MYLES	SALK INSTITUTE FOR BIOLOGICAL STUDIES	High Throughput Screen for Inhibitors of the mdm2/mdmx Interaction
WALKINSHAW, MALCOLM DOUGLAS	UNIVERSITY OF EDINBURGH	Identification of glycolytic pathway inhibitors against Trypanosoma cruzi pyruvat
WEISSBACH, HERBERT	FLORIDA ATLANTIC UNIVERSITY	High Throughput Assay for Activators and Inhibitors of MSRA
WENNERBERG, KRISTER	SOUTHERN RESEARCH INSTITUTE	Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein M
WHITESELL, LUKE J	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Identifying species-specific anti-malarial Hsp90 inhibitors using genetically engineered yeast
WILSON, SAMUEL H	U.S. NATIONAL INST OF ENVIRON HLTH SCIS	Discovery and Characterization of Human DNA Polymerase Beta Inhibitors
WOODGATE, ROGER	U.S. NATIONAL INST/CHILD HLTH/HUMAN DEV	High Throughput Screening to Identify Inhibitors of Human DNA Polymerase eta and polymerase iota
WU, MENG	JOHNS HOPKINS UNIVERSITY	Subtype-Specific Small Molecule Chemical Probes for Non-neuronal KCNQ1 Potassium Channel
WU, MENG	JOHNS HOPKINS UNIVERSITY	Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
WU, XIAOHUA	CAROLINAS MEDICAL CENTER	HTS for Enhancer of Glycosylation of Alpha Dystroglycan
XU, HAOXING	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Kinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion c
YOULE, RICHARD JAMES	U.S. NATIONAL INST/NEURO/DS/STROKE	High content screening for small molecule modulators of Pink1 expression and mito
YOUNG, RICHARD A	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Discovery of small molecule inhibitors of c-Myc/Mac dimerization and DNA binding
YUE, DAVID T	JOHNS HOPKINS UNIVERSITY	Modulators of CaV1.3 Ca2+ regulation
XU, WEI	UNIVERSITY OF WISCONSIN MADISON	Identification of ERalpha/ERbeta Heterodimer-specific Ligands by HTS
ZHANG, YAN JESSIE	UNIVERSITY OF TEXAS AUSTIN	Discovery of Inhibitors for Small C-terminal Domain Phosphatases
ZHAO, RUI (contact) FORD, HEIDE L	UNIVERSITY OF COLORADO DENVER	Identify inhibitors of the Six1/Eya interaction using high throughput screening
ZHAO, RUI (contact) ZHANG, QINGHONG	UNIVERSITY OF COLORADO DENVER	Identify Inhibitors of the Transcriptional Co-Repressor CtBP Using HTS for Cancer
ZHENG, WEI, Contact REMALEY, ALAN THOMAS	U.S. NATIONAL HUMAN GENOME RESEARCH INST	Identification of Acid Sphingomyelinase Inhibitors for the Treatment of Atherosclerosis
ZHENG, WEI (contact) SHILOH, YOSEF	U.S. NATIONAL HUMAN GENOME RESEARCH INST	HTS for Identifying Potential Drug Treatment of Ataxia-Telangiectasia
ZHUANG, ZHIHAO	UNIVERSITY OF DELAWARE	Discovery of inhibitors against ubiquitin specific protease in human DNA damage r

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**Solicitation of Assays for HTS in the Molecular Libraries Probe Production Centers Network (MLPCN) (R03/X01)**
**PAR-08-034 & PAR-08-035**
PI Name	Institution Name	Title
ABOOD, MARY E	CALIFORNIA PACIFIC MED CTR RES INSTITUTE	Screening for Selective Ligands for GPR55
AULD, DOUGLAS BELLER, MATHIAS (contact)	MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY	qHTS to Identify Modulators of Lipid Storage
AGOULNIK, ALEXANDER I.	BAYLOR COLLEGE OF MEDICINE	Small molecule agonists of the relaxin receptor
ANDROPHY, ELLIOT J	UNIV OF MASSACHUSETTS MED SCH WORCESTER	High Throughput Screen for SMA
BARAK, LAWRENCE S.	DUKE UNIVERSITY	Antagonists for the Orphan Receptor GPR-35
BARAK, LAWRENCE S	DUKE UNIVERSITY	Agonists and Antagonists for the Kappa Opioid Receptor
BASSLER, BONNIE L	PRINCETON UNIVERSITY	A High-Throughput Screen for LuxS Quorum-Sensing Inhibitors
BEZPROZVANNY, ILYA B.	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	HTS Screen for Small Molecule Inhibitors of Mint-PDZ Domain
BISHAI, WILLIAM RAMSES	JOHNS HOPKINS UNIVERSITY	Screen for Synthetic Lethality in Mycobacterium Tuberculosis
BOKOCH, GARY M.	SCRIPPS RESEARCH INSTITUTE	HTS For Inhibitors of NADPH Oxidase 1 (Nox1)
BRODSKY, JEFFREY L	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Identification of SV40 T Antigen Inhibitors: A Route to Novel Anti-Viral Reagent
BUGGE, THOMAS H	U.S. NAT'L INST/DENTAL/CRANIOFACIAL RES	Inhibitors of Cell Surface uPA Generation
BURHANS, WILLIAM C	ROSWELL PARK CANCER INSTITUTE CORP	A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide
BUSHWELLER, JOHN HACKETT	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Screening for Inhibitors of MLL Translocation Proteins in Leukemia
CHEN, YUAN	CITY OF HOPE/BECKMAN RESEARCH INSTITUTE	A high throughput screening assay for the identification of SUMOylation inhibitor
CIVELLI, OLIVIER	UNIV OF CALIFORNIA IRVINE	High-Throughput Assay for G-Protein Coupled Receptors in Pain Research
DENISON, MICHAEL STEVEN	UNIVERSITY OF CALIFORNIA DAVIS	High Throughput Screening for Activators of the Ah Receptor
DESHAIES, RAYMOND J	CALIFORNIA INSTITUTE OF TECHNOLOGY	High-Throughput Campaign to Identify Reversible Small Molecule Inhibitor of p97/C
ECKENHOFF, RODERIC G.	UNIVERSITY OF PENNSYLVANIA	High throughput screening of a general anesthetic binding site
ENGEL, DANIEL A	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	High Throughput Screen for Inhibitors of Influenza NS1 Protein Function
FLAUMENHAFT, ROBERT C	BETH ISRAEL DEACONESS MEDICAL CENTER	Chemical Genetic Analysis of Platelet Granule Secretion
FRICK, DAVID N.	NEW YORK MEDICAL COLLEGE	Hepatitis C VIrus NS3 Helicase Inhibitor Discovery
GARDINER, DONALD L	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	Identification of Inhibitors of the Plasmodium Falciparum M18 Metalloprotease
GILBERT, SHAWN ROBERT	UNIVERSITY OF ALABAMA AT BIRMINGHAM	Identification of Molecular Probes to Activate the Hypoxia Inducible Factor Pathw
GILEADI, OPHER (contact); VINDIGNI, ALESSANDRO	UNIVERSITY OF OXFORD	Small-molecule inhibitors of the human RECQ1 and Bloom DNA helicases
GOLUB, TODD R.	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Discovery of inhibitors of anti-apoptotic protein A1
GOULD, ROBERT	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Discovering Inhibitors of histone demethylase GASC-1
GREMBECKA, JOLANTA (contact) CIERPICKI, TOMASZ	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Screening for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leuke
HAGGARTY, STEPHEN J PAN, JEN (contact)	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Discovery of potent, and selective allosteric inhibitors of GSK-3b
HARDING, HEATHER P	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Screen for Inhibitors of 2' Phosphotransferase
HASLAM, DAVID B	WASHINGTON UNIVERSITY	A SCREEN FOR SMALL MOLECULE INHIBITORS OF SHIGA TOXIN AND RICIN ACTIVITY
HEIL, MARINTHA L	SOUTHERN RESEARCH INSTITUTE	A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activ
HEILIG, MARKUS ALEXANDER	U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM	Identification of Small Molecule Antagonists for the Neuropeptide Receptor Using
HERZBERG, OSNAT	UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE	HTP Screen of Compounds that Inhibit Giardia Fructose-1,6-Bisphosphate Aldolase
HONKANEN, RICHARD E	UNIVERSITY OF SOUTH ALABAMA	HTP screening for inhibitors of ser/the protein phosphatase 5
HUANG, SUI	NORTHWESTERN UNIVERSITY	A Novel HTP Assay for Identification of Compounds that Reduce PNC Prevalence
HUNG, DEBORAH T	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis
HWANG, INKYU	SCRIPPS RESEARCH INSTITUTE	The High Throughput Screening for Developing T Cell Immune Modulators
JARSTFER, MICHAEL B	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Allosteric Potentiators of the Oxytocin System for the Control of Social Motivation
KAUFMAN, RANDAL J	UNIVERSITY OF MICHIGAN AT ANN ARBOR	High Throughput Chemical Genomics to Identify Novel Inhibitors of CHOP
KOEHLER, CARLA M.	UNIVERSITY OF CALIFORNIA LOS ANGELES	Small molecule modulators for mitochondrial protein import
KOEHLER, CARLA M.	UNIVERSITY OF CALIFORNIA LOS ANGELES	Small Molecule Modulators for Redox Regulation in the Mitochondrial Intermembrane
KUPERSHMIDT, SABINA	VANDERBILT UNIVERSITY	Identification of compounds that protect HERG from block by proarrhythmic agents
LAI, KENT	UNIVERSITY OF MIAMI SCHOOL OF MEDICINE	Toward Improved Therapy for Classic Galactosemia
LEVINE, ROSS L	SLOAN-KETTERING INSTITUTE FOR CANCER RES	High Throughput Screen for JAK2V617F Mutant Selective Inhibitors
LI, MIN	JOHNS HOPKINS UNIVERSITY	Development of Chemical Probes for KCNQ Potassium Channels
LINDQUIST, SUSAN L.	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Reversing Antifungal Drug Resistance
LITTMAN, DAN R	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Screen for Small Molecule Compounds that Modulate the Transcriptional Activity of
MAKHINA, ELENA	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	High Throughput Screening for Potassium Channel Modulators
MAZIN, ALEXANDER V	DREXEL UNIVERSITY	A Screen for Modulators of Human Rad51, a Key DNA Repair Protein
MCDONOUGH, PATRICK M	VALA SCIENCES, INC	A High Throughput Imaging Assay for Hepatic Lipid Droplet Formation
MILLAN, JOSE LUIS	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	The Role of PHOSPHO1 in the Initiation of Skeletal Calcification
MISTELI, TOM	U.S. NATIONAL CANCER INSTITUTE	A high-throughput screen for pre-mRNA splicing modulators
MOORE, CLAIRE L; KUMAMOTO, CAROL A	TUFTS UNIVERSITY BOSTON	High throughput screening for polyadenylation inhibitors using the MLSCN library
NAKAMURA, KAZUHIRO	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain Interaction
PAULUS, HENRY	BOSTON BIOMEDICAL RESEARCH INSTITUTE	Intein inhibitors as potential TB drugs
PELLECCHIA, MAURIZIO	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Novel Chemical Probes Targeting the FRB Domain of mTOR
PELLETIER, JERRY	MC GILL UNIVERSITY	Interdicting Eukaryotic Translation Initiation Factor-RNA Interaction
REED, JOHN C	SANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCH	High Throughput Screening Assays for NOD1 and NOD2 Inhibitors
REED, JOHN C	SANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Chemical Modulation of the Siah-1 Pathway
REED, JOHN C	SANFORD-BURNHAM INSTITUTE FOR MEDICAL RESEARCH	HTS Assay for UBC13, a Mediator of Inflammatory Signaling
REISMAN, DAVID N	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Reverse the Epigenetic Suppression of BRM through High Throughput Screening
RODRIGUEZ, ANA	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	New Drugs for Acute and Chronic Stages of Trypanosome Cruzi
RUGGIERO, ALICIA M.	VANDERBILT UNIVERSITY	A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators
SCHMIDT, WALTER K.	UNIVERSITY OF GEORGIA (UGA)	Discovery of Specific Cell-Permeable Inhibitors of the Ras Converting Enzyme
STOCKWELL, BRENT R	COLUMBIA UNIV NEW YORK MORNINGSIDE	Screen for RAS-Selective Lethal Compounds and VDAC Ligands
STROSBERG, ARTHUR DONNY	SCRIPPS RESEARCH INSTITUTE	HTS Assay for Inhibitors of HCV Core Protein
SUN, HONGMIN	UNIVERSITY OF MISSOURI-COLUMBIA	High Throughput Screening for Small Compounds to Inhibit the Expression of Strept
TAUTZ, LUTZ	SANFORD-BURNHAM MEDICAL RESEARCH INSTIT	Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR
THORNTON, CHARLES A.	UNIVERSITY OF ROCHESTER	Inhibitors of MBNL1 - poly(CUG)binding
TOKARS, VALERIE L.	UNIVERSITY OF ILLINOIS AT CHICAGO	High Throughput Screening for Identifying Lead Compounds Against 3CLpro
VANDER HEIDEN, MATTHEW	DANA-FARBER CANCER INSTITUTE	Discovery of Lead Compounds which Modulate Tumor Specific Pyruvate Kinase M2 Acti
WALKINSHAW, MALCOLM DOUGLAS	UNIVERSITY OF EDINBURGH	Discovery of Lead Compounds Against Trypanosomiasis and Leishmaniasis Through Ind
WANG, ZHIYONG	SALK INSTITUTE FOR BIOLOGICAL STUDIES	High throughput screen for the master regulator of obesity and diabetes p/CIP
WERNER-WASHBURNE, MARGARET C.	UNIVERSITY OF NEW MEXICO	Chemical Screen of TOR pathway GFP fusion proteins in S. cerevisiae
WHITESELL, LUKE J	WHITEHEAD INSTITUTE FOR BIOMEDICAL RES	Identifying Small Molecules To Probe the Role of Heat Shock Factor 1 in Cancer
WILSON, DAVID M.	U.S. NATIONAL INSTITUTE ON AGING	High Throughput Screening to Identify Inhibitors of the Human Abasic Endonuclease
YANG, VINCENT W	EMORY UNIVERSITY	High Throughput Screen for Small Molecule Inhibitors of Colorectal Cancer Cell Pr
ZHENG, WEI	U.S. NATIONAL HUMAN GENOME RESEARCH INST	Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington?
ZHENG, WEI	U.S. NATIONAL HUMAN GENOME RESEARCH INST	Identification of Activators and Inhibitors of alpha-Glucosidase as Potential Cha
ZHENG, WEI	U.S. NATIONAL HUMAN GENOME RESEARCH INST	HTS for Identifying Activators and Inhibitors of Alpha-Galactosidase A for the Po

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**Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (R03/X01)**
**PAR-06-259** & **PAR-06-545**
PI Name	Institution Name	Title
BALLATORE, CARLO	UNIVERSITY OF PENNSYLVANIA	High Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fi
BUGGE, THOMAS H	U.S. NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH	Quantitative High Throughput Screening for Anthrax Toxin Inhibitors
BURKART, MICHAEL D	UNIVERSITY OF CALIFORNIA SAN DIEGO	A qHTS FRET-Quench Assay for 4?-Phosphopantethienyltransferases
BUSHWELLER, JOHN H	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Screening for Inhibitors of Runx and CBFb Translocation Products in Leukemia
COLLER, BARRY S	ROCKEFELLER UNIVERSITY	High Throughput Screen for Novel Inhibitors of Platelet Integrin alphaIIb-beta3
COOMBS, GARY	UNIVERSITY OF UTAH	The Role of Wnts in Stem Cell
DAY, BILLY W	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	HTS Assays for Microtubule Stabilizers
FREEZE, HUDSON H	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Therapeutic Inhibitors of Phosphomannose Isomerase
GARDINER, DONALD L (Contact); TRENHOLME, KATHARINE RUTH DALTON, JOHN PIU	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	High Through-Put Screening of Plasmodium Falciparum Aminopeptidases
GERSHENGORN, MARVIN C	U.S. NATIONAL INST DIABETES/DIGST/KIDNEY	Ligand Discovery for Thyroid-Stimulating Hormone Receptor (TSHR) by Virtual and H
GLASS, JONATHAN DAVID	EMORY UNIVERSITY	Discovering Calpain Inhibitors of Neurological Diseases
GRIMALDI, MAURIZIO	SOUTHERN RESEARCH INSTITUTE	An HTS Assay Based on Neuronal Human Cells to Identify Small Molecule Activators
HASELBECK, ROBERT JOHN	RX3 PHARMACEUTICALS, INC.	Identification of Target-Specific Antimicrobials
HELLER, STEFAN	STANFORD UNIVERSITY	Identification of Modulators of the TRPML3 and TRPN1 ion Channels
HOLMAN, THEODORE R	UNIVERSITY OF CALIFORNIA SANTA CRUZ	High Throughput and Virtual Screening for Human 12-LO, 15-LO-1, and 15-LO-2 Inhibitors
KOLE, RYSZARD	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Modulation of Alternative Splicing by HTS Identified Compounds
LARSON, RICHARD S	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	Multiplex Screening for ABC Transporter Inhibitors
LEISSRING, MALCOLM A	SCRIPPS RESEARCH INSTITUTE	HTS for Modulators of Beta-Amyloid Catabolism by Insulin-Degrading Enzyme
LEWIS, KIM	NORTHEASTERN UNIVERSITY	Screening C. Albicans Biofilms for Lethal Potentiators of Miconazole
LI, QIANJUN	UNIVERSITY OF ALABAMA AT BIRMINGHAM	A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
LIU, PU PAUL	U.S. NATIONAL HUMAN GENOME RESEARCH INST	High-Throughput Screening for Compounds Blocking Interaction Between CBFb-SMMHC a
MARSHALL, WALLACE	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Small Molecule Inhibitors of Cilia
MATTS, ROBERT L	OKLAHOMA STATE UNIVERSITY STILLWATER	High Throughput Screen for Hsp90 Inhibitors
MCDONOUGH, PATRICK M	VALA SCIENCES, INC	High Throughput Imaging Assay for Beta-Catenin
MCNEIL, MICHAEL R	COLORADO STATE UNIVERSITY – FORT COLLINS	HTS Screen of TB RmIC & RmID dTDP-Rhamnose Formation Enzymes
MILLAN, JOSE LUIS	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
MORRIS, JAMES CULVIN	CLEMSON UNIVERSITY	Identification of Inhibitors of Trypanosoma Brucei Hexokinases
NATARAJAN, AMARNATH	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	HTS to Identify Small Molecule Inhibitors of Phospho-Specific Protein-Protein Int
NUNNARI, JODI M	UNIVERSITY OF CALIFORNIA DAVIS	Chemical Genetic Screens for Mitochondrial Division and Fusion Inhibitors
PASSER, BRENT J	MASSACHUSETTS GENERAL HOSPITAL	A High-Throughput Screen to Identify Small Molecule Compounds That Augment
PELLECCHIA, MAURIZIO	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Novel Chemotypes Against Influenza A Virus
PELLETIER, JERRY	MCGILL UNIVERSITY	Screening for Small Molecule Inhibitors of Eukaryotic Translation Initiation
PLEMPER, RICHARD K.	EMORY UNIVERSITY	High Throughput Screening-Based Identification of Measles Virus Probes
REED, JOHN C	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins
REED, JOHN C	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Chemical Inhibitors of ER Stress
RON, DAVID	NEW YORK UNIVERSITY SCHOOL OF MEDICINE	Screening for Inhibitors of the Integrated Stress Response
ROZANOV, DMITRI	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Screening for Chemicals that Potentiate TRAIL-Induced Apoptosis of Cancer Cells
SEVERSON, WILLIAM E	SOUTHERN RESEARCH INSTITUTE	A Cell Based HTS Approach for the Discovery of New Inhibitors of the H5N1 Virus
SEVERSON, WILLIAM E	SOUTHERN RESEARCH INSTITUTE	A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV
SHOICHET, BRIAN K	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Promiscuous and Specific Inhibitors of Cruzain
SMITH, SUSAN M.E.	EMORY UNIVERSITY	HTS to Find Inhibitors of p47phox, a Regulatory Protein of Noxes
SMITHGALL, THOMAS EDWARD	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Targeting HIV-1 Nef with Small Molecules
STAUFFACHER, CYNTHIA V	PURDUE UNIVERSITY WEST LAFAYETTE	Scaffolds for Synthesis of Probes Directed Against Class II HMG-CoA Reductases
STOCKWELL, BRENT R	COLUMBIA UNIV NEW YORK MORNINGSIDE	Luciferase Screen for MDM2 E3 Ligase Inhibitors
TOBIAS, PETER S	SCRIPPS RESEARCH INSTITUTE	High Throughput Screening for Toll-Like Receptors
WANDINGER-NESS, ANGELA	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	HTS to Identify Specific Small Molecule Inhibitors and Activators of Ras and Ras-
WANG, QIMING JANE	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	IMAP-Based Fluorescent Polarization Assay for High Throughput Screening of Protein
YIN, XIAO-MING	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	High-Content Cell-Based Screening for Modulators of Autophagy
YUAN, JUNYING	HARVARD UNIVERSITY (MEDICAL SCHOOL)	A High Throughput Screen for Inhibitors of a Novel Necrotic Cell Death Pathway
ZHENG, WEI	U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE	HTS for Identifying the Cell-Membrane Permeable IMPase Inhibitors
ZHENG, WEI	U.S. NATIONAL HUMAN GENOME RESEARCH INSTITUTE	HTS for Identification of Inhibitors Against the ERK Signaling Pathway using a Ho

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**Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147**
**PAR-06-259**
PI Name	Institution Name	Title
DE FIGUEIREDO, PAUL	TEXAS A&M UNIVERSITY SYSTEM	Drug Discovery for Bone Marrow Failure Diseases
FRANK, DAVID A	DANA-FARBER CANCER INSTITUTE	Modulators of STAT transcription factors for the targeted therapy of cancer
GRIFFIN, PATRICK R	SCRIPPS RESEARCH INSTITUTE	HTRF screen for identifying SRC-1 selective agonists of PPARgamma
GU, HOWARD H	OHIO STATE UNIVERSITY	High Throughput Screening for Cocaine Antagonists
KUHN, PETER	SCRIPPS RESEARCH INSTITUTE	EphB4-Ephrin-B2 Antagonists for Angiogenesis and Carcinogenesis Inhibition
LIOU, HSIOU-CHI	IMMUNETARGET, INC.	Development of Screening Assays for NF-KB-Rel Inhibitors
MARTINEZ, ELISABETH D	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	High Throughput Screens for Epigenetic Modulators
MERCOLA, MARK	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Screen for Compounds that Promote Cardiomyocyte Cell Cycle Entry
NICHOLSON, BENJAMIN	PROGENRA, INC.	Identification of Compounds that Modulate Human Deubiquitinase Function
NIRENBERG, MARSHALL WARREN	U.S. NATIONAL HEART LUNG & BLOOD INS	Molecules that Enhance CREB Activity
QU, ZHICAN	SOUTHERN RESEARCH INSTITUTE	Cell-Based Screening for Anti-Angiogenic Agents
REED, JOHN C	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	High Throughput Screening Assay for Hsp70 Inhibitors
ROGERS, JACK T	MASSACHUSETTS GENERAL HOSPITAL	MLSCN SCReen of the Amyloid precursor protein 5'untranslated region
SEIDAH, NABIL G.	CLINICAL RESEARCH INSTITUTE OF MONTREAL	High Throughput Screens for targets of the Proprotein Convertases Furin, PC5, SKI-1 and PCSK9 Using Cell-Based Assays
SHOICHET, BRIAN K.	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Promiscuous and Specific Inhibitors of B-lactamase
SKLAR, LARRY A.	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	HTS for BCI-2 Family Multiplex
SUN, YI	UNIVERSITY OF MICHIGAN-ANN ARBOR	Synthetic Lethal Screen for Compounds to Kill Cancer Cells with p53 Mutation

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**Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (X01) Reissue of PAR-05-147**
**PAR-06-259**
PI Name	Institution Name	Title
AULD, DOUGLAS S	NIH/NHGRI	Identification of lkappaBalpha Stabilizers in a Human Lymphoma Cell Line Using A
BRISSON, MARNI J	UNIVERSITY OF PITTSBURGH	Homogeneous Flourescence Intensity High Throughput Assay for Cdc25B Phosphatase I
DESAI, SANJAY A	NAT'L INST OF ALLERGY/INFEC DISE	High-Throughput Screen for Antagonists of the Plasmodial Surface Anion Channel (PSAC)
FIELDS, GREGG B	FLORIDA ATLANTIC UNIVERSITY	ADAMTS/MMP Drug Development
GRESHAM, HATTIE D	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	Small Molecule Inhibition of Staphylococcus Aureus Virulence
HAMMOCK, BRUCE D	UNIVERSITY OF CALIFORNIA DAVIS	Novel sEH Inhibitors for the Therapeutic Treatment of Hypertension and Inflammat
HOFFMANN, MICHAEL	UNIVERSITY OF WISCONSIN	Targeting a Protein Interaction Site on Smad Transcription Factors
KATZENELLENBOGEN, JOHN A	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Screen for Coactivator Binding Inhibitors to Block Estrogen Action
KELLY, JEFFERY W	SCRIPPS RESEARCH INSTITUTE	High Throughput Screening for Protein Misfolding Disease Therapeutics
LEYH, THOMAS S.	YESHIVA UNIVERSITY	Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae
MCPIKE, MARK P	ORTHOSYSTEMS, INC.	Rapid Mix and Measure HTS Assays for Anti-NCp7 Drug Discovery
PELLECCHIA, MAURIZIO	BURNHAM INSTITUTE	Chemical Tools to Investigate the Protein Folding/Degradation Machinery
STRONGIN, ALEX	BURNHAM INSTITUTE	Screening Chemicals to Suppress MT1-MMP Synthesis in Cancer
THOMPSON, TODD A	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	Activators of Prostate Cell Differentiation
WELLS, JAMES A	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Inhibitors of Caspase-1 and Caspase-7
WILLIAMSON, JAMES R	SCRIPPS RESEARCH INSTITUTE	High Throughput Screen for Inhibitors of the HIV Rev-RRE RNA Interaction
YAFFE, MICHAEL	MASSACHUSETTS INST OF TECHNOLO	High Throughput Screening for Inhibitors of the Polo Box Domain of Human Polo-Lik
ZHENG, WEI	NIH/ NHGRI	HTS for Identification of Glucocerebrosidase Activators and Inhibitors as Pharmac

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**Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (X01) Reissue of PAR-05-060**
**PAR-05-147**
PI Name	Institution Name	Title
CONN, P JEFFREY	VANDERBILT UNIVERSITY	Discovery of novel allosteric modulators of the M1 muscarinic receptor
HARSAY, EDINA	UNIVERSITY OF KANSAS LAWRENCE	Chemical Genetics Screens to Identify Modulators of Post-Golgi Transport
KURET, JEFF A	OHIO STATE UNIVERSITY	Ligands for premortem diagnosis and treatment of Alzheimer's disease
LEWIS, KIM A	NORTHEASTERN UNIVERSITY	A Screen for Novel Antimicrobials
LI, XIAOLING	ORPHAGEN PHARMACEUTICALS	High Throughput Screening of Select Orphan Nuclear Receptors
MCHENRY, CHARLES S	UNIVERSITY OF COLORADO DENVER/HSC AURORA	Conducting a HTS against a Multi-protein DNA Replication System
MERCOLA, MARK	BURNHAM INSTITUTE	Screening for Compounds That Modulate Insulin Promoter Activity in TRM-67 Cells
MERCOLA, MARK	BURNHAM INSTITUTE	Screening for Compounds That Modules Insulin Promoter Activity in MIN-6 Cells
MILLAN, JOSE LUIS	BURNHAM INSTITUTE	Pharmacological inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
MUSTELIN, TOMAS M	BURNHAM INSTITUTE	HTS for HePTP Inhibitors-a leukemia target
MUSTELIN, TOMAS M	BURNHAM INSTITUTE	HTS for LYP inhibitors-an autoimmunity target
NISWENDER, COLLEEN M	VANDERBILT UNIVERSITY	Discovery of novel allosteric agonists of the M4 muscarinic receptor
PARNIAK, MICHAEL A	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	HTS assays for inhibitors of HIV RNase H
PASQUALE, ELENA B	BURNHAM INSTITUTE	EphA4 Receptor Antagonists for Nervous System Repair
PAVITT, GRAHAM D	UNIVERSITY OF MANCHESTER, UK	High-throughput screen for a therapeutic agent for elF2B-related disorders
PIAZZA, GARY A	SOUTHERN RESEARCH INSTITUTE	Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance
PROSSNITZ, ERIC R	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	MLSCN Assay for Ligands of GRP30 and Classical Estrogen Receptors
PROSSNITZ, ERIC R	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	MLSCN Assay for Inhibitors of Arrestin-GPR Interactions
REED, JOHN C	BURNHAM INSTITUTE	Chemical Inhibitors of anti-apoptotic protein Bfl-1
REED, JOHN C	BURNHAM INSTITUTE	Chemical inhibitors of antigen receptor-induced NF-?Beta activation
RUBENSTEIN, AMY L	ZYGOGEN, LLC	Zebrafish Lipid Metabolism Assay
SHARLOW, ELIZABETH R.	UNIVERSITY OF PITTSBURGH	Fluroscence polarization assay for PLK1 inhibitors
SKLAR, LARRY A	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin
SKOWYRA, DOROTA	ST. LOUIS UNIVERSITY	ATP Hydrolysis-dependent disassembly of the 26S proteosome as an HTS assay for fl
STRONGIN, ALEX Y	BURNHAM INSTITUTE	Inhibitors of the NS3 Proteinase of West Nile and Dengue Viruses
STURGESS, MICHAEL A	CHAPERONE TECHNOLOGIES, INC.	Development of a HTS assay for Inhibitors of bacterial DnaK
WATTS, VAL J	PURDUE UNIVERSITY WEST LAFAYETTE	Allosteric Modulators of D1 Receptors
YI, FANG	YALE UNIVERSITY	Identifying novel Hsp90 Inhibitors by disrupting its cochaperone interaction usin

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**Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network (MLSCN) (R03)**
**PAR-05-060**
PI Name	Institution Name	Title
APPEL, BRUCE	VANDERBILT UNIVERSITY	A Screen For Drugs That Promote Oligodendrocyte Formation in Zebrafish
CHEN, BENJAMIN P	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	TRANSLATIONAL CONTROL OF RADIATION-INDUCED APOPTOSIS
CHENG, XIAODONG	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	Chemical Genetic Screening of Oncogene RAS-Based Inhibitors
CHIOSIS, GABRIELA	SLOAN-KETTERING INSTITUTE FOR CANCER RES	FP Assay for Isolation of Hsp90 Inhibitors
CHIOSIS, GABRIELA	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Isolation of Inhibitors of Her-Kinase Expression
DIAMOND, SCOTT L	UNIVERSITY OF PENNSYLVANIA	Multiplexed HTS of Serine and Cysteine Proteases
EDWARDS, BRUCE	UNIVERSITY OF NEW MEXICO ALBUQUERQUE	Assay for Formylpeptide Receptor Family Ligands
FU, HAIAN	EMORY UNIVERSITY	AlphaScreen Technology for High Throughput Screening of 14-3-3/Raf-1 Disruptors
GOLDFARB, DAVID S	UNIVERSITY OF ROCHESTER	Yeast Lifespan Chemical Screening
LAZO, JOHN S	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Chemical Complementation Assay for MKP-1
LAZO, JOHN S	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Chemical Complementation Assay for MKP-3
LAZO, JOHN S	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	In Vitro High Throughput Screening Assay for MKP-1
LAZO, JOHN S	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	In Vitro High Throughput Screening Assay for MKP-3
MAYER, THOMAS	COLUMBIA UNIVERSITY HEALTH SCIENCES	Cellular Assay for TNF Alpha Induced NF Kappa B Translocation
MAYER, THOMAS	COLUMBIA UNIVERSITY HEALTH SCIENCES	Cellular Assay for TNF Alpha Induced E-Selectin Expression
MAYER, THOMAS	COLUMBIA UNIVERSITY HEALTH SCIENCES	CELLULAR ASSAY:PRESENTATION OF THE ADHESION MOLECUL
MUSTAEV, ARKADY	PUBLIC HEALTH RESEARCH INSTITUTE	Development of the HTS Assay for E. Coli RNA Polymerase (RNAP)
NISWENDER, COLLEEN M	VANDERBILT UNIVERSITY	Measurement of GPCR-mediated thallium flux through GIRK Channels
PAUMET, FABIENNE	COLUMBIA UNIVERSITY HEALTH SCIENCES	Unraveling the Molecular Mechanisms of Phagocytosis
ROTHMAN, JAMES E	COLUMBIA UNIVERSITY HEALTH SCIENCES	Aggregation and Clearance of Mutant Huntingtin
ROTHMAN, JAMES E	COLUMBIA UNIVERSITY HEALTH SCIENCES	Regulation of Neurotransmitter Transporter Recycling
SANNA M. GERMANA	SCRIPPS RESEARCH INSTITUTE	MLSCN HTS Assays R03 - S1P1
TEITLER, MILT	ALBANY MEDICAL COLLEGE OF UNION UNIV	Human 5HT 1E Serotonin Receptor Drug Development
WALKER, SUZANNE	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Identification of O-GlcNAc Transferase Inhibitors by HTS
WHITE, E. LUCILE	SOUTHERN RESEARCH INSTITUTE	High Throughput Screen for Mycobacterium Tuberculosis Pantothenate Synthetase
WILKINSON, KEITH D	EMORY UNIVERSITY	HTS Assay for Inhibitors of BAP1, a BRCA1 Associated Deubiquitinating Enzyme
WILLIAMS, DAVID L	ILLINOIS STATE UNIVERSITY	HTS for Inhibitors of Schistosoma Mansoni Peroxiredoxins
ZHOU, MING	COLUMBIA UNIVERSITY HEALTH SCIENCES	Small-Molecule Modulators of a Family of Voltage-Dependent Potassium Channels

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Technology Development

**Assay Development for High Throughput Molecular Screening (R21)**
**PAR-10-182**
PI Name	Institution Name	Title
BRUICK, RICHARD K (contact) HAMZA, IQBAL	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	High Throughput Screen Development for Modulators of Heme Transporters
CARAVAN, PETER D	MASSACHUSETTS GENERAL HOSPITAL	High throughput assay for fibrin-binding probes
CARSTENS, RUSS PAUL	UNIVERSITY OF PENNSYLVANIA	High throughput assays for modulators of splicing switches during the EMT
CUNNINGHAM, KYLE W	JOHNS HOPKINS UNIVERSITY	Assays for Non-selective Cation Channel Inhibitors
DESHAIES, RAYMOND J	CALIFORNIA INSTITUTE OF TECHNOLOGY	A Screen for Inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases
GARDINER, DONALD L (contact) BROWN, CHRISTOPHER LESLIE MCCARTHY, JAMES STANISLAUS TRENHOLME, KATHARINE RUTH	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	Assay Development for lead identification of anti-gametocydial agents
GOLDBERG, ALFRED L	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Assay Development for Screening of Specific IKK alpha Kinase Inhibitors
JARDETZKY, THEODORE S	STANFORD UNIVERSITY	Development of an IgE:Receptor Fluorescence Assay For High Throughput Screening
JOHNSTON, PAUL A.	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	HCS Assay to Identify Disruptors of AR-TIF2 Protein-Protein Interactions
LUO, JUN-LI	SCRIPPS FLORIDA	Assay Development for Screening of Specific IKK alpha Kinase Inhibitors
MARTINEZ-SOBRIDO, LUIS	UNIVERSITY OF ROCHESTER	Identification of compounds that activate interferon to treat viral infections
MERCOLA, MARK	SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE	HTS for inhibitors of RBPJ co-repressor complex
ROHATGI, RAJAT	STANFORD UNIVERSITY	High-throughput imaging of Hedgehog pathway components at the primary cilium
STROSBERG, ARTHUR DONNY	SCRIPPS RESEARCH INSTITUTE	Development of a HTS assay to screen for inhibitors of HCV core NS3h interactions
SWANSTROM, RONALD I (contact) JANZEN, WILLIAM PERRY	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	High Throughput Screen For HIV-1 MA/CA Processing Site Inhibitors
WEAVER, C DAVID	VANDERBILT UNIVERSITY	An HTS-compatible Assay to Probe Muscarinic Receptor Modulation of the M current
ZHOU, PENGBO	WEILL MEDICAL COLLEGE OF CORNELL UNIV	Development of high throughput assays to identify small molecule inhibitors of the CLR4 ubiquitin ligase

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**Assay Development for High Throughput Molecular Screening (R21)**
**PAR-08-024**
PI Name	Institution Name	Title
ADES, SARAH E	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	Assay Development for Inhibitors of the Essential sRNA-Sigma E Virulence Factors
ALDRICH, COURTNEY C	UNIVERSITY OF MINNESOTA TWIN CITIES	A Fluorescence Polarization Assay for Fatty Acid Adenylating Enzymes
BALCH, WILLIAM EDWARD (Contact) CONKRIGHT, JULIANA J	UNIV OF MASSACHUSETTS MED SCH WORCESTER	HTS Approach to Correction of Alpha-1-Antitrypsin Misfolding Disease
BEINBORN, MARTIN	NEW ENGLAND MEDICAL CENTER HOSPITALS	Identification of Class B GPCR Modulators Using Hypersensitive Receptor Probes
BEREZOVSKA, OKSANA	MASSACHUSETTS GENERAL HOSPITAL	Development of a HTS assay for modulators of presenilin 1 conformation
BERG, LESLIE J (Contact); ANDREOTTI, AMY; KANG, JOONSOO	NEW ENGLAND MEDICAL CENTER HOSPITALS	Screening for inhibitors of the T cell Tec Kinase (lTK)
BRAUTIGAN, DAVID L	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Triple threat screening for modifiers of Protein Ser/Thr Phosphatase 2C
BRENMAN, JAY (contact) SEXTON, JONATHAN ZACHARY	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	HTS assay development to identify regulators of peroxisome biogenesis/function
BURANDA, TIONE	UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR	Development of HTS Assays for Inhibitors of Viral-Cell Interactions
BURRIS, THOMAS P	SCRIPPS RESEARCH INSTITUTE	Development and Validation of a REV-ERBalpha HTS Assay
BURRIS, THOMAS P	SCRIPPS RESEARCH INSTITUTE	Development of a High Throughput Screening Assay for RORgamma
BURRIS, THOMAS P	SCRIPPS RESEARCH INSTITUTE	Development of an HTS assay to identify FXR antagonists
BUSHWELLER, JOHN HACKETT	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Screening for Inhibitors for ERG in Prostate Cancer
CASTILLA, LUCIO H	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Identification of CBFB-MYH11 specific inhibitors for acute myeloid leukemia
CHAUDHARY, PREET M	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Small Molecule Inhibitors of K13-Induced NF-kB Activation
CHEN, YUAN	CITY OF HOPE/BECKMAN RESEARCH INSTITUTE	High Throughput Assays to Identify Inhibitors of SUMO-mediated Protein-Protein Interactions
CHENG, XIAODONG	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	High throughput assay for novel pharmacological probes Targeting cAMP signaling
CHO, CHARLES YOON-HYUNG	NOVARTIS INST FOR FUNCTIONAL GENOMICS	Screen for Small Molecule Regulators of Retinal Progenitor Epithelial Cell Phagocytosis
CHUANG, TSUNG-HSIEN	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Cell-based assay for high-throughput screening of TLR3 activators
CHUNG, WOOK JOON	UNIVERSITY OF ALABAMA AT BIRMINGHAM	A Novel HTS Cell-Based Imaging Assay to Identify Chemical Correctors for deltaF508-CFTR
CUI, LIWANG	PENNSYLVANIA STATE UNIVERSITY-UNIV PARK	Development of a cell-based method for high-throughput drug screening in malaria
DEITERS, ALEXANDER	NORTH CAROLINA STATE UNIVERSITY RALEIGH	High-Throughput Assay for the Discovery of Small Molecule Inhibitors of microRNA
DENTON, JEROD S	VANDERBILT UNIVERSITY	Chemical probes of the astroglial potassium channel Kir4.1
DIAMOND, SCOTT, (contact) BLOBEL, GERD A	UNIVERSITY OF PENNSYLVANIA	Development of a Cell-Based Screen for Inhibitors of the FOG-1-NuRD Interaction
DUERKSEN-HUGHES, PENELOPE J	LOMA LINDA UNIVERSITY	HTS Screening for Inhibitors of HPV 16 E6/Caspase 8 Binding
ENGEL, DANIEL A. (Contact) BARIC, RALPH S	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Yeast Based Assays for Chemical Screens Against SARS-CoV Target
ENGEL, JUAN C	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	HTS assay for the intracellular stages of T. cruzi, the vector of Chagas disease
FABRIS, DANIELE	UNIVERSITY OF MARYLAND BALT CO CAMPUS	MS-based screening of candidate inhibitors of protein-RNA and RNA-RNA interaction
FORD, JAMES MATTHEW	STANFORD UNIVERSITY	A High-Throughput Assay for DNA Repair Activity in the Presence of Aberrant BRCA1
GARDNER, KEVIN H (Contact) BRUICK, RICHARD K	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	High Throughput Screen Development for Modulators of PAS/Coactivator Interactions
GILMOUR, BRIAN P.	RESEARCH TRIANGLE INSTITUTE	Screening Assay for Human TAAR1 Ligands
GOBER, JAMES W	UNIVERSITY OF CALIFORNIA LOS ANGELES	Identification small molecule inhibitors of the bacterial morphogenetic complex
GOCHIN, MIRIAM DR	TOURO UNIVERSITY OF CALIFORNIA	Assay development for high affinity non-peptide HIV-1 gp41 inhibitors
HASLAM, DAVID B.	WASHINGTON UNIVERSITY	An HTS Assay For Inhibitors Of C. Difficle Toxins
HODGSON, LOUIS	YESHIVA UNIVERSITY	High Throughput Screening Assay of Cdc42 Activation in Cancer
HONKANEN, RICHARD E	UNIVERSITY OF SOUTH ALABAMA	Development of a HTS-assay for inhibitors of a type 2C protein phosphatase (PPMD1/WIP1)
JACKSON, MARY	COLORADO STATE UNIVERSITY-FORT COLLINS	Assay Development of M. Tuberculosis Class II Aldolase
JIANG, ZHEN YUE	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	High content screening assay for activators of glucose transporter GLUT4
JEGLA, TIMOTHY J.	SCRIPPS RESEARCH INSTITUTE	HTS Assays for Specific Modulators of Neuronal Acid-Sensitive K+ Channels
KAISER, PETER	UNIVERSITY OF CALIFORNIA IRVINE	Identification of Small Molecules for Reactivation of p53 Cancer Mutants
KAUFMAN, PAUL D	UNIV OF MASSACHUSETTS MED SCH WORCESTER	HTS development for targeted anti-fungal small molecules
KAYE, KENNETH M	BRIGHAM AND WOMEN'S HOSPITAL	Inhibitors of Kaposi’s Sarcoma Herpesvirus
KING, MICHAEL P	THOMAS JEFFERSON UNIVERSITY	Development of HTS assays for mitochondrial function
KRALLI, ANASTASIA	SCRIPPS RESEARCH INSTITUTE	A HTS assay for agonists of the orphan nuclear receptor ERRg
LIEBERMAN, PAUL M.	WISTAR INSTITUTE	Assay Development for Inhibitors of KSHV
LIN, HENING	CORNELL UNIVERSITY ITHACA	High-throughput assays for the development of SIRT5-specific inhibitors
LUO, MINKUI	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Developing High Throughput Assay to Identify Protein Methyltransferase Inhibitors
MADDEN, DEAN R	DARTMOUTH COLLEGE	Small-Molecule Targeting of CFTR:PDZ Trafficking Interactions
MAEGAWA, GUSTAVO HENRIQUE BOFF	JOHNS HOPKINS UNIVERSITY	A HTS assay to identify molecular probes for arylsulfatase A
MAITRA, RANGAN	RESEARCH TRIANGLE INSTITUTE	High-throughput Assay to Identify CFTR Inhibitors
MARTIN, THOMAS F.	UNIVERSITY OF WISCONSIN MADISON	SCREENING FOR INHIBITORS OF VESICLE EXOCYTOSIS
MCDONALD, PATRICIA H.	SCRIPPS RESEARCH INSTITUTE	A novel approach to enable a HTS-compatible Galanin 3 receptor cell-based assay
MCNEIL, MICHAEL R.	COLORADO STATE UNIVERSITY-FORT COLLINS	HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
MILLER, SAMUEL I.	UNIVERSITY OF WASHINGTON	Assay Development for High Throughput Molecular Screening
MUSSER, SIEGFRIED M.	TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR	High Throughput Screening for Tat Transport Inhibitors
NAPIERALA, MAREK	UNIVERSITY OF TEXAS MD ANDERSON CAN CTR	Targeting trinucleotide repeats-induced transcriptional silencing in Friedreich's Ataxia
NAPPER, ANDREW	ALFRED I. DU PONT HOSP FOR CHILDREN	Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
NEUBIG, RICHARD R	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Assay development for cellular RGS7 family modulators
PANDA, SATCHIDANANDA	SALK INSTITUTE FOR BIOLOGICAL STUDIES	Melanopsin Photoactivation Assay
PASQUALE, ELENA B	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Cell-based screening for EphA2 receptor inhibitors
PAULUS, HENRY (contact) EMERSON, CHARLES P.	BOSTON BIOMEDICAL RESEARCH INSTITUTE	Identification of inhibitors of hedgehog autoprocessing
PETRUKHIN, KONSTANTIN	COLUMBIA UNIVERSITY HEALTH SCIENCES	Development of the HTS assay for visual cycle inhibitors
PINTER, ABRAHAM	UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL	HTS assays for reagents capable of unmasking conserved neutralization sites in HIV-1 Env
POTTER, JAMES DOUGLAS	UNIVERSITY OF MIAMI SCHOOL OF MEDICINE	HTS for Regulated Muscle Thin Filament Function
PYLE, APRIL D.	UNIVERSITY OF CALIFORNIA LOS ANGELES	Development of High Content Screens for Human Pluripotent Stem Cells
REITER, JEREMY F ARKIN, MICHELLE R	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	A novel high content screen for regulators of ciliogenesis and Hedgehog signaling
ROGERS, JACK T	MASSACHUSETTS GENERAL HOSPITAL	RNA Targeted Screens of the Prion 5'UTR
ROSEN, HUGH	SCRIPPS RESEARCH INSTITUTE	HTS for inhibitors of NADPH Oxidase 2 (NOX 2)
ROTH, GREGORY	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	HTS to Identify Novel Chemical Probes for CCR6
SACKS, DAVID B.	BRIGHAM AND WOMEN'S HOSPITAL	High throughput screen to identify inhibitors of Salmonella invasion
SATTERTHWAIT, ARNOLD	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Development of HTS assays for Bcl-2 converters
SIBLEY, DAVID R.	U.S. NATIONAL INST/NEURO/DS/STROKE	Functionally-selective ligands for the D2 dopamine receptor
SMITH, HAROLD C	OYAGEN, INC.	Development of a High Throughput Screen for Antagonists of Vif Dimerization
STRANGE, KEVIN	VANDERBILT UNIVERSITY	A high throughput screen for inhibitors of nematode detoxification genes
STROSBERG, ARTHUR DONNY	SCRIPPS RESEARCH INSTITUTE	Novel Assay for Small Molecule Inhibitors of core-NS5A Interaction
SUZUKI, CAROLYN K	UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL	High throughput screening assays to identify small molecules that target the ClpXP protease
TOBIAS, PETER S	SCRIPPS RESEARCH INSTITUTE	High Throughput Screening Assays to Identify Inhibitors of TLR4 Signaling
TOMASINI-JOHANSSON, BIANCA	UNIVERSITY OF WISCONSIN MADISON	Modulators of Fibronectin Fibrillogenesis
TSE-DINH, YUK-CHING	NEW YORK MEDICAL COLLEGE	HTS assay development targeting Yersinia pestis topoisomerase I
TURK, BENJAMIN E	YALE UNIVERSITY	Identification of exosite-targeting inhibitors of anthrax lethal factor
WAGNER, ERIC J	UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON	Assay for Compounds that Elicit Misprocessing of Small Nuclear RNA
WAGNER, GERHARD	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Assays for Discovery of Translation Inhibitors
WALKER, SUZANNE L	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Cell-based HTS for Compounds that Block Virulence Factor Expression in MRSA
WALSH, KENNETH B	UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA	Real Time Screening for GIRK1/4 Channel Blockers
WANDINGER-NESS, ANGELA	UNIVERSITY OF NEW MEXICO	HTS to identify small molecules that disrupt Rab GTPase activator and effector protein interactions
WANG, SHAOMENG	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Discovery of small-molecule inhibitors of the Beta-Catenin / BCL-9 Interaction
WILLIAMS, RICHARD THOMAS	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	Synergy Screening of BCR-ABL-driven Lymphoid Leukemias
WOODARD, RONALD WESLEY	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Mining the kds Pathways - New Source of Novel Antibacterial Targets
YAFFE, MICHAEL B (Contact) FLOYD, SCOTT R	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-content screening for modifiers of the DNA damage response
YANG, PRISCILLA LI-NING	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Development of Cellular Assays of Dengue Virus Infection
ZHANG, QISHENG	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	High Throughput Assay Development for ARFGAP Modulators
ZHAO, RICHARD YUQI	UNIVERSITY OF MARYLAND BALTIMORE	Fission Yeast as a HTS Platform for New Molecular Probes of HIV-1 VPR-Medicated A
ZHONG, TAO P	VANDERBILT UNIVERSITY	High content assay for zebrafish cardiomyocyte development
ZWEIFACH, ADAM	UNIVERSITY OF CONNECTICUT STORRS	A High-throughput Screen of Lytic Granule Exocytosis

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**Assay Development for High Throughput Molecular Screening (R21) This is a reissue of RFA-RM-07-001**
**RFA-RM-07-008**
PI Name	Institution Name	Title
ERNST, NANCY LEWIS	SEATTLE BIOMEDICAL RESEARCH INSTITUTE	A High Throughput Assay to Identify Onhibitors of Trypanosome RNA Editing Ligase
FENG, XU	UNIVERSITY OF ALABAMA AT BIRMINGHAM	Cell-Based Assays for Identifying Anti-RANK Signaling Agents
GRAEF, ISABELLA A	STANFORD UNIVERSITY	HTS Assay Development for Modulators of a Nuclear Import/Export Switch
GRANNEMAN, JAMES G	WAYNE STATE UNIVERSITY	HTS for Novel Activators of Adipocyte and Myocyte Lipolysis
HARSAY, EDINA	UNIVERSITY OF KANSAS LAWRENCE	Pathway-Specific Inhibitors of Post-Golgi Transport
HAZBUN, TONY (contact) DAVISSON, VINCENT JO	PURDUE UNIVERSITY WEST LAFAYETTE	High-throughput Chemotyping of Yeast Signature Strains Reflecting Hsp90 Biology
ILAGAN, MA.XENIA G	WASHINGTON UNIVERSITY	Screening for Novel Modulators of Notch/RBPjk Interactions
JOHNSON, JEFFREY DALE	METABOLEX, INC.	High Throughput Screening to Identify Inhibitors of a Fifth Mammalian Hexokinase
KAO, GARY D	UNIVERSITY OF PENNSYLVANIA	The Zebrafish Radioresponse for High-Throughput and -Content Molecular Screening
KAYE, KENNETH M	BRIGHAM AND WOMEN'S HOSPITAL	Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection
KRANZ, ROBERT G	WASHINGTON UNIVERSITY	HTS for Cytochrome C Synthesis Pathways
MAITRA, RANGAN	RESEARCH TRIANGLE INSTITUTE	Anti-inflammatory Assay for Cystic Fibrosis
NIKOLOV, DIMITAR B	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
PETRIE, HOWARD T	SCRIPPS RESEARCH INSTITUTE	Assay Development and Screening for Notch Agonists
PETRUKHIN, KONSTANTIN	COLUMBIA UNIVERSITY HEALTH SCIENCES	Development of the HTS Assay for Agonists of the Orphan Nuclear Receptor NR2E3
PRICE, BRENDAN D	DANA-FARBER CANCER INSTITUTE	Identification of Inhibitors of the Tip60 Histone Acetyltransferase
REICHMAN, MELVIN	LANKENAU INSTITUTE FOR MEDICAL RESEARCH	Fructosamine-3-Kinase Assay Development and Validation for HTS
SALVESEN, GUY S	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Development of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs]
WOLF, DIETER A	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	Optimized High-Throughput Screen for Small Molecule Inhibitors of P27 Degradation
XU, BO	SOUTHERN RESEARCH INSTITUTE	An HTS Assay for Inhibitors of NBS1-ATM Interactions
ZHOU, JIANHUA	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Cell Based Assays for Compounds That Regulate Tau Exon 10 Splicing

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**Assay Development for High Throughput Molecular Screening (R21) Reissue of RFA-RM-06-004, which was previously released November 2, 2005 RFA-RM-05-011; Reissue for FY2005 of RFA-RM-04-012**
**RFA-RM-07-001**
PI Name	Institution Name	Title
ARANY, ZOLTAN P.	DANA-FARBER CANCER INSTITUTE	High throughput screening for modulators of the transcriptional coactivator PGC-1
ARGON, YAIR	CHILDREN'S HOSPITAL OF PHILADELPHIA	Developing HTS assays for the functions of the chaperone GRP94
BLENIS, JOHN	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Development of a high content cell based screen for inhibitors of the mTOR signal
CLARDY, JON	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Target-Based High-Throughput Screens for Plasmodium falciparum Malaria
CLEARY, MICHAEL Lq	STANFORD UNIVERSITY	Inhibitors of MLL-Menin Interaction
DUTTA, ANINDYA	UNIVERSITY OF VIRGINIA CHARLOTTESVILLE	Screen for TIP60 Inhibitors
FIDOCK, DAVID A	YESHIVA UNIVERSITY	A cell-based HTS for delayed death inhibitors of the malarial parasite plastid
GERACE, LARRY R	SCRIPPS RESEARCH INSTITUTE	Screen for Small Molecule Inhibitors of Nuclear Protein Import
GINSBERG, MARK H	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling
GOCHIN, MIRIAM	TOURO UNIVERSITY CALIFORNIA	High-Throughput Screening for Human Immunodeficiency Virus Fusion Inhibitors
HARRIS, JASON B	MASSACHUSETTS GENERAL HOSPITAL	Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
HODDER, PETER SIMMONS	SCRIPPS RESEARCH INSTITUTE	HTS assays for discovery of novel beta-lactamase inhibitors via click chemistry
HUANG, QIHONG	WISTAR INSTITUTE	A Cell-based Screen for Small Molecule Modulators of the miRNA Pathway
JAIN, ANJALI	CEDARS-SINAI MEDICAL CENTER	Functional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling
JARDETZKY, THEODORE S	NORTHWESTERN UNIVERSITY	Functional Genomics Tools for HER2 heterodimers and Androgen Receptor Signaling
KAMPF, J PATRICK	FFA SCIENCES, LLC	An HTS Assay for the Discovery of Specific Inhibitors of Adipocyte FABP
LAVAN, BRIAN	METABOLEX, INC.	High Throughput Screening for Identification of AKR1C3 Inhibitors
LI, RONGBAO	SOUTHERN RESEARCH INSTITUTE	HTS Assay Development for Discovery of Specific PYK2 Inhibitors
PETERSON, JEFFREY R	INSTITUTE FOR CANCER RESEARCH	Allosteric, Small-Molecule Inhibitors of Actin Nucleation by the Formin mDia1
PIAZZA, GARY A	SOUTHERN RESEARCH INSTITUTE	A Novel HTS Cell-Based Assay For Cyclic GMP
ROGERS, JACK T	MASSACHUSETTS GENERAL HOSPITAL	MLSN Screen of the PD Alpha Synuclein 5'UTR
ROGERS, MICHAEL S	CHILDREN'S HOSPITAL BOSTON	Assay for Inhibitors of Angiogenesis and Anthrax Toxin Receptor 1
RYDER, SEAN PATRICK	UNIV OF MASSACHUSETTS MED SCH WORCESTER	Small molecule effectors of maternal gene expression in C. elegans embryogenesis
SANDER, CHRIS	SLOAN-KETTERING INSTITUTE FOR CANCER RES	High-throughput identification of compounds that modulate the TGF-beta pathway
SMITH, LAYTON H	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	HTS to identify chemical probes of the apelin receptor signaling pathway
WUTTKE, DEBORAH S	UNIVERSITY OF COLORADO AT BOULDER	Development of a HTS Assay Targeting End Protection of Telomeres

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**Assay Development for High Throughput Molecular Screening (R03/R21) Reissue for FY2006 of RFA-RM-05-011**
**RFA-RM-06-004**
PI Name	Institution Name	Title
AGAISSE, HERVE F	YALE UNIVERSITY SCHOOL OF MED	High-throughput screen for compounds affecting intracellular pathogen infection
AIKEN, CHRISTOPHER R	VANDERBILT UNIVERSITY	Discovering Novel Inhibitors of HIV-1 Maturation
AYAD, NAGI G	SCRIPPS FLORIDA RESEARCH INSTITUTE	Small-molecule Inhibitors of Wee1 Degradation and Mitotic Entry
BALK, STEVEN P	BETH ISRAEL DEACONESS MEDICAL CENTER	HTS for Androgen Receptor Antagonists that Recruit NCoR
BOTTINI, NUNZIO	LA JOLLA INST FOR ALLERGY & IMMUNOLGY	Fluorogenic PTP Assay for Use in HTS of Novel LYP Inhibitors
BROWN, STEVEN J	SCRIPPS RESEARCH INSTITUTE	Development of a High Throughput Screening Galanin 3 Receptor Assay
CRAWFORD, BRETT E	ZACHARON PHARMACEUTICALS, INC.	Development of cell-based assays for discovery of GIcNAc-TV inhibitors
CUNNINGHAM, KYLE W	JOHNS HOPKINS UNIVERSITY	Assays for compounds that block or stimulate yeast cell death
DAY, BILLY W	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	High Throughput/Content Screens for Dynein Inhibitors
DELISA, MATTHEW P	CORNELL UNIVERSITY	A cell-based screen for inhibitors of intracellular Abeta aggregation
DENTON, JEROD S	VANDERBILT UNIVERSITY	Identification of novel modulators of ROMK K+ channel activity
DESHMUKH, MOHANISH P	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Chemical Probes for Uncovering Differential Regulators of Apoptosis in Cells
DJABALLAH, HAKIM	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Novel & Selective Small Molecular Inhibitors of Human Peptide Deformylase
HODGSON, LOUIS	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Screening for RhoC Activation and its modulation by GEFs
HOFFMANN, F. MICHAEL	UNIVERSITY OF WISCONSIN MADISON	An HTS Assay for Inhibitors of Smad-dependent Transcriptional Responses to TGF-beta
HOGENESCH, JOHN B	UNIVERSITY OF PENNSYLVANIA	A Dual Transcriptional and High Content Assay for Cryptochrome
HUGHES, ROBERT E	BUCK INSTITUTE FOR AGE RESEARCH	A cell-based screen for small molecule binders of mutant huntingtin messenger RNA
JEGLA, TIMOTHY J	SCRIPPS RESEARCH INSTITUTE	Development of HTS Assays for Sub-Threshold Potassium Channels
JOHNSON, GARY L	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Inhibitor Screens for Five MAPK Kinase Kinases Important in Human Disease
KHANNA, PYARE L	DISCOVERX CORPORATION	HTS Technology for Discovery of Drugs Targeting GPCR Oligomers
LANDICK, ROBERT C	UNIVERSITY OF WISCONSIN MADISON	High-Throughput Identification of RNA polymerase inhibitors in vivo
LEISNER, TINA M	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Developing HTS Assays for Novel Intracellular Regulators of Integrin Activation
LEVINE, FRED	BURNHAM INSTITUTE FOR MEDICAL RESEARCH	High-Throughput Screen for Beta-Cell Replication
LINDER, MAURINE E	WASHINGTON UNIVERSITY	Assay Development to Identify Palmitoylation Inhibitors of Neuronal Proteins
LUO, HONGBO R	CHILDREN'S HOSPITAL BOSTON	High throughput screening for inhibitors of Akt plasma membrane translocation.
MARZLUFF, WILLIAM F	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Screen for molecules inhibiting histone pre-mRNA processing
MCNEIL, MICHAEL R	COLORADO STATE UNIVERSITY-FORT COLLINS	Glucosamine-1-phosphate and serine acetylases: HTS assays and configurations
NETTLES, KENDALL W	SCRIPPS RESEARCH INSTITUTE	Assay Development for Identification of ER-NFkB Pathway Selective Agents
NEUBIG, RICHARD R	UNIVERSITY OF MICHIGAN	Multiplexed flow cytometry screens for RGS inhibitors
NIKOLOVSKA-COLESKA, ZANETA	THE UNIVERSITY OF MICHIGAN	Discovery and characterization of novel small molecule inhibitors of Mcl-1
PADGETT, RICHARD A	CLEVELAND CLINIC FOUNDATION	Screen for Small Molecule Inhibitors of Mammalian Spliceosomes
PERRIMON, NORBERT	HARVARD UNIVERSITY (MEDICAL SCHOOL)	High-throughput screening assay development for axonopathic neurodegeration
SALAVATI, REZA	MCGILL UNIVERSITY	RNA as the catalyst for screening drugs against trypanosomatids
THACHER, SCOTT M	ORPHAGEN PHARMACEUTICALS	Small Molecule Screen for Circadian and Metabolic Transcription Factors
TRAYNELIS, STEPHEN F	EMORY UNIVERSITY	Identification of protease activated receptor-2 modulators
WAHLESTEDT, CLAES	SCRIPPS RESEARCH INSTITUTE	Assay Development Relating to the HTS of the Neuropeptide Y-Y2 Receptor
WEISS, ERIC L	NORTHWESTERN UNIVERSITY	Development of a robust high throughput assay for the discovery of RAM network inhibitors
WELLS, JAMES A	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Activators of Procaspase-7
WESSLING-RESNICK, MARIANNE	HARVARD UNIVERSITY (SCH OF PUBLIC HLTH)	Fluorescence-based screen to probe hepcidin-ferroportin interactions
WILLIAMSON, JAMES R	SCRIPPS RESEARCH INSTITUTE	HTS for Discovery of Inhibitors of STAR Protein-RNA complexes
XIE, XINMIN SIMON	SRI INTERNATIONAL	Development of HTS Platform for Human Fatty Acid Transport Protein 4 Using FLIPR
ZHU, MICHAEL X	OHIO STATE UNIVERSITY	High throughput screening of ligands of TRP channels

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PI Name	Institution Name	Title
BACHER, ADELBERT	TECHNICAL UNIVERSITY MUNICH	HTS on Riboflavin and Terpene Biosynthetic Enzymes
CAFFREY, MICHAEL S	UNIVERSITY OF ILLINOIS AT CHICAGO	High Throughput Screening of HIV Entry Inhibitors
CARTEGNI, LUCA	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Development of HTS Assays to Identify Specific Alternative Splicing Modulators
CHRISTENSEN, KENNETH A	CLEMSON UNIVERSITY	Assay for Molecules that Inhibit Anthrax Intoxication and Pathological Angiogenes
CLARDY, JON C	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Phenotypic-based High Throughput Screens for Plasmodium Falciparum Malaria
CRAWFORD, BRETT E	ZACHARON PHARMACEUTICALS, INC.	Cell-Based Screen for Inhibitors of Mucin-Type O-Linked Glycans
CUEVAS, BRUCE D	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	MEKK2/3-MEK5 Protein Interaction/Activation/ERK5 Pathway
DELPIRE, ERIC J	VANDERBILT UNIVERSITY	Identification of Novel Modulators of CL-dependent Transport Processes via HTS
DEVI, LAKSHMI A	MOUNT SINAI SCHOOL OF MEDICINE OF NYU	Assay to Screen Ligands that Selectively Activate Opioid Receptor Heterodimers
ENGELMAN, DONALD M	YALE UNIVERSITY	A High Capacity Screen for Membrane-Active Compounds
GUPTA, VINEET	MASSACHUSETTS GENERAL HOSPITAL	Developing HTS Assays for Discovery of Small Molecule Regulators of Integrins
JARSTFER, MICHAEL B	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	A High Throughput Screen for Telomerase Assembly
KAMPF, J PATRICK	TORREY PINES INSTITUTE/MOLECULAR STUDIES	A Fluorescent HTS Assay for the Discovery of FABP Binding Inhibitors
KAN, CHEN-CHEN	KECK GRADUATE INST OF APPLIED LIFE SCIS	Human CD4+ T Cell Based High Throughput Assay for Drug-Resistant HIV-1 Proteases
KATZ, RICHARD A	INSTITUTE FOR CANCER RESEARCH	GFP-Based Assays to Probe Transcriptional and Post-Transcriptional Controls
KHANNA, PYARE L	DISCOVERX CORPORATION	HTS Cell Based EFC Assays for GPCR Drug Discovery
LANSBURY, PETER T	BRIGHAM AND WOMEN'S HOSPITAL	A High-Throughput Assay for SOD1 Aggregation Inhibitors
MARSH-ARMSTRONG, NICHOLAS R	KENNEDY KRIEGER RESEARCH INSTITUTE, INC.	Photoreceptor Degeneration Assay in Transgenic Xenopus Reporter Line
MCKERROW, JAMES H	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	High Throughput Assay for Screening Compounds Against T. Brucei
MECSAS, JOAN C	TUFTS UNIVERSITY BOSTON	Inhibitors of Yersinia Yop Type III Secretion and Translocation
MOHAN, ROYCE	UNIVERSITY OF KENTUCKY	Novel High Content Vascular Patterning Assay
MORRIS, DAVID G	YALE UNIVERSITY	High Throughput Molecular Screening for Compounds that Alter Tgfb1 Signaling Tgfb1 Signaling
NISWENDER, COLLEEN M	VANDERBILT UNIVERSITY	A Direct Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as the Prototype
PASQUALE, ELENA B	BURNHAM INSTITUTE	EphA4 Receptor Antagonists for CNS Regeneration
ROGERS, JACK T	MASSACHUSETTS GENERAL HOSPITAL	Small HTS Molecules Targeting APP 5' Untranslated Region
SCHARENBERG, ANDREW M	CHILDREN'S HOSPITAL AND REG MEDICAL CTR	TRPM2 HTS Screening Assay Development
SCHMID, MOLLY B	KECK GRADUATE INST OF APPLIED LIFE SCIS	Genetic-Based Whole Cell Assays for Discovery of Novel Antibacterials
SCHMIDT, WALTER K	UNIVERSITY OF GEORGIA	HTS-Based Identification of Novel Rce1p Inhibitors
SIDEROVSKI, DAVID P	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Real-Time Fluorescence Assays of RGS Domain GAP Activity
SPERANDIO, VANESSA	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Screen for Quorum Sensing Molecular Inhibitors
STIVERS, JAMES T	JOHNS HOPKINS UNIVERSITY	High Throughput Assay for Topoisomerase Enzyme Targets
STUDER, LORENZ	SLOAN-KETTERING INSTITUTE FOR CANCER RES	HTS Screen for Neural Differentiation in Human ES Cells
SWAAN, PETER W	UNIVERSITY OF MARYLAND BALT PROF SCHOOL	High-Throughput Assay for the Intestinal Peptide Transporter
TRUBETSKOY, VLADIMIR S	QUINTESSENCE BIOSCIENCES	Development of a Robust HTS Assay to Profile Glucuronidation of Small Molecules
WALDMAN, TODD	GEORGETOWN UNIVERSITY	Isogenic Cell-Based Screens for Cancer - Targeting Oncogenic B-Catenin
WEIS, KARSTEN	UNIVERSITY OF CALIFORNIA BERKELEY	Using Chemical Biology to Study the Small GTPase Ran
XIE, XINMIN S	SRI INTERNATIONAL	Development of HTS Assay for K(ATP) Channels Using FLIPR
YE, QI-ZHUANG	INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS	A Fluorescence Polarization Assay for Methyltransferases
ZACHARIAS, DAVID A	UNIVERSITY OF FLORIDA	A Cell-Based HT Imaging Assay for Palmitoylation

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**High Throughput Molecular Screening Assay Development (R03)**
**RFA-RM-05-011**
PI Name	Institution Name	Title
BEZPROZVANNY, ILYA B	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	Screen for blockers of a CaV2.2-Mint-PDZ1 association
BURGESS, RICHARD R	UNIVERSITY OF WISCONSIN MADISON	LRET-based HT Screening for Inhibitors of Transcription
BURNS, CHARLES G	MASSACHUSETTS GENERAL HOSPITAL	HTS assay for zebrafish embryonic heart function
CHIOSIS, GABRIELA	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Development of HTS assays probing Hsp90 inhibition
CHUNG, RAYMOND T	MASSACHUSETTS GENERAL HOSPITAL	Chemical Genetics to Identify Cellular Regulators of HCV
CLARDY, JON C	HARVARD UNIVERSITY (MEDICAL SCHOOL)	High-throughput Screens for P. falciparum Malaria
CONN, P JEFFREY	VANDERBILT UNIVERSITY	Development of a High Throughput Assay for Allosteric P*
DAVID, SUNIL A	UNIVERSITY OF KANSAS LAWRENCE	Novel High-throghput Assay for Angiogenesis Inhibitors
FENTON, ROBERT G	UNIVERSITY OF MARYLAND BALT PROF SCHOOL	High-throughput screen for inhibitors of Mcl-1
FRANK, DAVID A	DANA-FARBER CANCER INSTITUTE	High Throughput Screening for Modulators of STAT5
GOLDFARB, DAVID S	UNIVERSITY OF ROCHESTER	Molecular Screen for Lifespan Extension in Yeast
HARSAY, EDINA	UNIVERSITY OF KANSAS LAWRENCE	Identifying compounds that target post-Golgi secretion
JAYARAMAN, VASANTHI	UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON	High throughout screening assay for glutamate receptors
KIEFF, ELLIOTT D.	BRIGHAM AND WOMEN'S HOSPITAL	Screening of Epstein Barr Virus Replication
KIRKEN, ROBERT A	UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON	Screening for small molecule inhibitors of Stat5
KUTSCH, OLAF	UNIVERSITY OF ALABAMA AT BIRMINGHAM	A GFP Based HTS Assay for HIV-1 Tat Inhibitors
LITHGOW, GORDON	BUCK INSTITUTE FOR AGE RESEARCH	C. elegans, Aging and High Throughput Screening
LU, YILING	UNIVERSITY OF TEXAS MD ANDERSON CAN CTR	Tissue Lysate Arrays for Molecular Screening
MANION, MICHAEL K	FRED HUTCHINSON CANCER RESEARCH CENTER	Methods to identify BCL-2 ’gain of function“ inhibitors
MORISSEAU, CHRISTOPHE HP	UNIVERSITY OF CALIFORNIA DAVIS	Cyanohydrin based fluorescent substrates of sEH
PERRIMON, NORBERT	HARVARD UNIVERSITY (MEDICAL SCHOOL)	High-throughput screen for host factors in Listeria infection
ROSENFELD, STEVEN S	COLUMBIA UNIVERSITY HEALTH SCIENCES	Development of High Throughput Screening Assays to Targ*
THACHER, SCOTT M	ORPHAGEN PHARMACEUTICALS	Small Molecular Screen for Thymocyte Drug Target
TORTORELLA, DOMENICO	MOUNT SINAI SCHOOL OF MEDICINE OF NYU	Luminescent assay to identify ER dislocation inhibitors
TSE-DINH, YUK-CHING	NEW YORK MEDICAL COLLEGE	Development of a HTS system in E. coli for topoisomeras*
WALDMAN, TODD A	GEORGETOWN UNIVERSITY	Isogenic Cell-Based Screens for Cancer: Targeting PTEN
WILSON, ROBERT B	UNIVERSITY OF PENNSYLVANIA	High throughput screen for cyclin D1 inhibitors
WRIGHT, KENNETH L	H. LEE MOFFITT CANCER CTR & RESEARCH INS	High Throughput H3-K9 Methyltransferase Inhibitor Screen
XIE, SIMON X	SRI INTERNATIONAL	HTS Assay for Ca 3 T-type Channels Using FLIPR
YAFFE, MICHAEL B	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	High-Throughput Assay Design for Polo Kinase Inhibitors

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**Exploratory Centers for Cheminformatics Research (P20)**
**RFA-RM-05-012**
PI Name	Institution Name	Title
BRENEMAN, CURTIS M	RENSSELAER POLYTECHNIC INSTITUTE	Establishment of the RPI Exploratory Center for Cheminformatics
CLEMONS, PAUL A	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	General Data-analysis Tools to Relate Chemical Diversity to Biological Outcomes
FOX, GEOFFREY C	INDIANA UNIVERSITY BLOOMINGTON	Chemical Informatics Cyberinfrastructure
HUGHES-OLIVER, JACQUELINE M	NORTH CAROLINA STATE UNIVERSITY RALEIGH	Comparative and Web-Enabled Virtual Screening
SHEDDEN, KERBY	UNIVERSITY OF MICHIGAN AT ANN ARBOR	MACE - Michigan Alliance for Cheminformatic Exploration
TROPSHA, ALEXANDER	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Carolina Exploratory Center for Cheminformatics Research

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**Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41)**
**RFA-RM-09-007**
PI Name	Institution Name	Title
AUBE, JEFFREY	UNIVERSITY OF KANSAS LAWRENCE	Pilot Scale Libraries Inspired by Natural Products
DOEMLING, ALEXANDER SIEGFRIED	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Protein protein interaction directed libraries
GUNATILAKA, LESLIE	UNIVERSITY OF ARIZONA	Diverse Molecular Libraries from Unique Endosymbiotic Fungi
PHILLIPS, ANDREW J	UNIVERSITY OF COLORADO AT BOULDER	Robust New Chemistries for Heterocycles
SIGMAN, MATTHEW S	UNIVERSITY OF UTAH	Discovery Based Studies of Medicinally Relevant Pharmacophore Libraries
WILLIAMS, PHILIP	UNIVERSITY OF HAWAII AT MANOA	Accessing Cyanobacterial Chemical Diversity: A Unique Natural Product Library

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**New Methodologies for Natural Products Chemistry (R01)**
**RFA-RM-09-005**
PI Name	Institution Name	Title
BACHMANN, BRIAN O (contact); MCLEAN, JOHN ALAN	VANDERBILT UNIVERSITY	New Methodologies for Accelerating Natural Product Discovery
CICHEWICZ, ROBERT HENRY	UNIVERSITY OF OKLAHOMA NORMAN	Accessing Natural Products from Silent Biosynthetic Pathways
JENSEN, PAUL R	UNIVERSITY OF CALIFORNIA SAN DIEGO	A sequenced-based approach for improved small molecule discovery
SCHMIDT, ERIC W	UNIVERSITY OF UTAH	Rapid Screening and Dereplication of Marine Symbiotic Natural Products
TANG, YI	UNIVERSITY OF CALIFORNIA LOS ANGELES	A Robust Platform for Reconstituting and Engineering Iterative Megasynthases

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**Pilot-Scale Libraries for High-Throughput Screening (P41)**
**RFA-RM-06-003**
PI Name	Institution Name	Title
BAURES, PAUL WILLIAM	UNIVERSITY OF TULSA	Molecular Libraries from Imidazole-4,5-Dicarboxylic Acid
GEORG, GUNDA I	UNIVERSITY OF MINNESOTA TWIN CITIES	Libraries for HTS: Privileged Structures in Sparsely Populated Chemical Space
GILBERTSON, SCOTT R	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	Synthesis of Pilot Libraries Based on Medicinal Relevant Scaffolds
GRAY, NATHANAEL S	DANA-FARBER CANCER INSTITUTE	Inhibitors of Kinase Activation
HOUGHTEN, RICHARD A	TORREY PINES INST FOR MOLECULAR STUDIES	Stereochemically /Structurally Diverse Pilot Scale Libra
HOUGHTEN, RICHARD A	TORREY PINES INST FOR MOLECULAR STUDIES	Highly Diverse and Structurally Varied Heterocyclic Libraries for the MLSMR
KRCHNAK, VIKTOR	UNIVERSITY OF NOTRE DAME	Combinational synthesis of bisheterocyclic libraries
KWON, OHYUN	UNIVERSITY OF CALIFORNIA LOS ANGELES	Pilot-Scale Library Production Based on Phosphine Catalysis of Allenes
LAROCK, RICHARD C	IOWA STATE UNIVERSITY	Heterocyclic /Carbocyclic Libraries for High Throughput
PARKER, MATTHEW A	CHEMDIV, INC.	New Regions of Diversity Space in Ergot-Based Libraries
SCHROEDER, FRANK CLEMENS	BOYCE THOMPSON INST FOR PLANT RESEARCH	Arthropod-Based Libraries for High Throughput Screening
SMITH, AMOS B	UNIVERSITY OF PENNSYLVANIA	Pilot-Scale Libraries for High-throughput Screening (P41)
WEST, LYNDON M	UNIVERSITY OF GEORGIA (UGA)	“Drug-Like” Marine Natural Products Library
YU, MARVIN S	FLUOROUS TECHNOLOGIES, INC.	Diversity-Oriented Synthesis of Novel Heterocyclic and Natural Product-Like Libraries

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**Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41) This is a reissue of RFA-RM-05-014**
**RFA-RM-08-003**
PI Name	Institution Name	Title
GILBERTSON, SCOTT R	UNIVERSITY OF TEXAS MEDICAL BR GALVESTON	Pilot Scale Libraries Based on Biologically Active Scaffolds
HANSON, PAUL R	UNIVERSITY OF KANSAS LAWRENCE	Probing Diversity Space with Novel Pilot Scale Libraries
KURTH, MARK J	UNIVERSITY OF CALIFORNIA DAVIS	Complex Heterocycles and Hybrid Strategies for Pilot Scale Libraries
LUESCH, HENDRIK (Contact) PAUL, VALERIE J	UNIVERSITY OF FLORIDA	Pilot-Scale Libraries of Marine Cyanobacterial Natural Products
MARTIN, STEPHEN	UNIVERSITY OF TEXAS AUSTIN	Generating Diverse Pilot-Scale Libraries for Screening
MOLANDER, GARY A	UNIVERSITY OF PENNSYLVANIA	Novel Boronic Acids for Pilot-Scale Screening
REYNOLDS, ROBERT C	SOUTHERN RESEARCH INSTITUTE	Pilot-Scale Libraries Based on Nucleoside Templates for the ML Initiative
SCHAUS, SCOTT EDWARD	BOSTON UNIVERSITY	Structural and Sterochemically Diverse Heterocycles for the Small Molecule Reposi
SHEN, BEN	UNIVERSITY OF WISCONSIN MADISON	Natural Products from Under-explored Microorganisms
TAN, DEREK S	SLOAN-KETTERING INSTITUTE FOR CANCER RES	Diversity-Oriented Synthesis of Natural Product-based Libraries for the MLSMR
WIPF, PETER	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	Novel Heterocyclic Libraries
WRIGHT, AMY E	FLORIDA ATLANTIC UNIVERSITY	Production of Pilot Scale Libraries of Marine Natural Products

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**Pilot-Scale Libraries for High-Throughput Screening (P41)**
**RFA-RM-05-014**
PI Name	Institution Name	Title
BURGESS, KEVIN	TEXAS A&M UNIVERSITY SYSTEM	Evolving Libraries of Bivalent Compounds
HANSON, PAUL R	UNIVERSITY OF KANSAS LAWRENCE	Probing Diversity Space with Novel Pilot Scale Libraries
KURTH, MARK J	UNIVERSITY OF CALIFORNIA DAVIS	UCD Combinatorial Center - Novel and Diverse Pilot-Scale Library Production
LEE, KUO-HSIUNG	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	CHEMICAL DIVERSITY LIBRARIES FROM MEDICINAL PLANTS
PORCO, JOHN A	BOSTON UNIVERSITY CHARLES RIVER CAMPUS	Generation of Stereochemically and Structurally Complex Chemical Libraries
SCHREIBER, STUART L	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Versatile Diversity-oriented Small Molecule Libraries for Chemogenetics
TAN, DEREK S	MEMORIAL SLOAN-KETTERING CANCER CENTER	Diversity-Oriented Synthesis of Natural Product-based Libraries for the MLSCN
WRIGHT, JEFFREY L	UNIVERSITY OF NORTH CAROLINA WILMINGTON	Diverse Chemical Libraries from Photosynthetic Marine Microalgae

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**New Methodologies for Natural Products Chemistry (R01) This is a reissue of RFA-RM-05-013**
**RFA-RM-08-004**
PI Name	Institution Name	Title
CLARDY, JON	HARVARD UNIVERSITY (MEDICAL SCHOOL)	Molecule-to-gene approaches to new natural products
PETERS, REUBEN J	IOWA STATE UNIVERSITY	A Modular Approach for Combinatorial Biosynthesis of Functionalized Terpenoids
ROMO, DANIEL	TEXAS A&M UNIVERSITY SYSTEM	New Methods for Simultaneous Arming and SAR Studies of Natural Products

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**New Methodologies for Natural Products Chemistry (R01)**
**RFA-RM-05-013**
PI Name	Institution Name	Title
BURKART, MICHAEL	UNIVERSITY OF CALIFORNIA SAN DIEGO	Proteomic Methodologies for Polyketide Biosynthesis
DOYLE, DONALD F	GEORGIA INSTITUTE OF TECHNOLOGY	Natural Product Biosynthesis by Chemical Complementation
HANDELSMAN, JO E	UNIVERSITY OF WISCONSIN MADISON	Intracellular Screens for Discovery of Natural Products in Metagenomic Libraries
MILLER, MARVIN J	UNIVERSITY OF NOTRE DAME	Novel Derivatization/Functionalization of Natural Products
ORJALA, JIMMY	UNIVERSITY OF ILLINOIS AT CHICAGO	Microscale LC-MS and NMR Methodology for Rapid Natural Products Chemistry
WANG, CLAY C	UNIVERSITY OF SOUTHERN CALIFORNIA	Platforms for Nonribosomal Peptide Manipulation Additional Information

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**Molecular Libraries Screening Instrumentation (R01)**
**RFA-RM-08-020**
PI Name	Institution Name	Title
EDWARDS, BRUCE S.	UNIVERSITY OF NEW MEXICO	Advancing High Throughput Flow Cytometry

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**Molecular Libraries Screening Instrumentation (R01)**
**RFA-RM-04-020**
PI Name	Institution Name	Title
GASCOYNE, PETER R	UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER	Reconfigurable microfluidic assay platform for molecular Library Screening
KRON, STEPHEN J	UNIVERSITY OF CHICAGO	Molecular Library Screening By MALDI-TOF Scanning of Functional Peptide Arrays
LARSON, DALE N	HARVARD UNIVERSITY (MEDICAL SCHOOL)	HTS of Small Molecule-Protein Interactions
LITVINOV, DMITRI	UNIVERSITY OF HOUSTON	Development of Nanomagnetic Sensor Array For High Throughput Molecular Screening
MA, HAICHING	REACTION BIOLOGY CORPORATION	Microarraying and Screening Chemical Libraries
PRICE, JEFFREY H	BURNHAM INSTITUTE	Continuous-Imaging HT Screening Instrument
VO-DINH, TUAN	DUKE UNIVERSITY	Ultra-High-Throughput Screening (uHTS) Based on Surface-Enhanced Raman Scattering
ZHU, XIANGDONG	UNIVERSITY OF CALIFORNIA DAVIS	High-Speed Label-Free Optical Detection System for Small-Molecule Microarrays

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**Novel Preclinical Tools for Predictive ADME-Toxicology (R21)**
**RFA-RM-04-023**
PI Name	Institution Name	Title
BENET, LESLIE Z	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Transporter-Enzyme Interplay Evaluation via Microfluidic HTS Cell Culture Devices
GANEY, PATRICIA E	MICHIGAN STATE UNIVERSITY	Gene Expression in Drug-inflammation Models as Predictive of Idiosyncratic ADRs
HAYSTEAD, TIMOTHY A	DUKE UNIVERSITY	Proteome Mining as a Predicitve Tool of Drug Toxici ty
HOPFINGER, ANTON J	CHEM21 GROUP, INC.	Novel Descriptors and Informatics Methods for Predictive ADMET Modeling
MA, PETER X	UNIVERSITY OF MICHIGAN AT ANN ARBOR	Nano Fibers for ADME/Toxicology
MACDONALD, JEFFREY M	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Human Enterohepatic Cell Model for Predictive Toxicology
MACRAE, CALUM A	MASSACHUSETTS GENERAL HOSPITAL	Zebrafish Assays Predictive for Drug-Induced Cardiac Repolarization Toxicity PS-149
SUMNER, SUSAN J	RESEARCH TRIANGLE INSTITUTE	Metabolomics: Markers of Drug-Induced Liver Injury
TROPSHA, ALEXANDER E	UNIVERSITY OF NORTH CAROLINA CHAPEL HILL	Robust computational framework for predictive ADME-Tox Modeling
ZACHAREWSKI, TIMOTHY R	MICHIGAN STATE UNIVERSITY	Human Stem Cells for Toxicity Screening

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Development of High Resolution Probes for Cellular Imaging

**Innovation In Molecular Imaging Probes (R21)**
**RFA-RM-04-021**
PI Name	Institution Name	Title
BOLSKAR, ROBERT D	TDA RESEARCH, INC.	Cut Nanotube Capsules for MR Imaging
BOPPART, STEPHEN A	UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN	Magnetomotive Optical Molecular Imaging Probes
BOYLE, TIMOTHY J	SANDIA CORP-SANDIA NATIONAL LABORATORIES	Flourescent Ceramic Nanoprobes
BULTE, JEFF W	JOHNS HOPKINS UNIVERSITY	Developing a CEST Reporter Gene
DAYTON, PAUL A	UNIVERSITY OF CALIFORNIA DAVIS	High-Sensitivity Molecular Imaging with Ultrasound
DOUGLAS, TREVOR	MONTANA STATE UNIVERSITY (BOZEMAN)	Targeted MRI with Protein Cage Architectures
GAO, JINMING	UNIVERSITY OF TEXAS SW MED CTR/DALLAS	MFe2O4-Loaded Polymer Micelles as Ultra-Sensitive MR Molecular Probes
HALPERN, HOWARD J	UNIVERSITY OF CHICAGO	Magnitude Improvement of Molecular Signaling Imaging
KURHANEWICZ, JOHN	UNIVERSITY OF CALIFORNIA SAN FRANCISCO	Hyperpolarized 13c NMR Studies of Prostate Cancer
MACH, ROBERT H	WASHINGTON UNIVERSITY	RADIOLABELED PROBES FOR IMAGING CASPASE 3 ACTIVATION
MATTREY, ROBERT F	UNIVERSITY OF CALIFORNIA SAN DIEGO	Molecular Imaging with Ultrasound Contrast Agents
POMPER, MARTIN G	JOHNS HOPKINS UNIVERSITY	PSMA-based Gene Reporter-Probe System

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**Development of High Resolution Probes for Cellular Imaging (P20)**
**RFA-RM-04-001**
PI Name	Institution Name	Title
BURGESS, KEVIN	TEXAS A&M UNIVERSITY SYSTEM	Fluorescent Probes for Multiplexed Intracellular Imaging
DICKSON, ROBERT M	GEORGIA INSTITUTE OF TECHNOLOGY	Sub-nm dendrimer-metal nanoclusters as ultrabright, mod*
MOERNER, WILLIAM E	STANFORD UNIVERSITY	Single-Molecule Fluorophores for Cellular Imaging
NIE, SHUMING	EMORY UNIVERSITY	Bioaffinity Nanoparticle Probes for Bioimaging
PISTON, DAVID W	VANDERBILT UNIVERSITY	Probes for Quantitative Optical and Electron Microscopy
SIMON, SANFORD M	ROCKEFELLER UNIVERSITY	Imaging single proteins in vivo with quantum dots
SINGER, ROBERT H	YESHIVA UNIVERSITY	Light-Activated Gene Expression in Single Cells
TING, ALICE Y	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	Library-based development of new optical imaging probes
TSIEN, ROGER	UNIVERSITY OF CALIFORNIA SAN DIEGO	Genetically Targetable Labels For Light and EM