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2010 Transformative R01 Award Recipients

 

Full descriptions are available for those projects with a released Notice of Grant Award.
 

Schematic representation depicting specific binding of genomic loci by Zinc Finger proteins, and light-tunable modulation of gene expression. Paola Arlotta, Ph.D. and J. Keith Joung, M.D., Ph.D.
Massachusetts General Hospital / Harvard Medical School
Feng Zhang, Ph.D.
Massachusetts Institute of Technology
Project Title: Genome-wide Light-inducible Tuning of Transcriptional Network Dynamic
 

 

Human gastrointestinal tract bacteriaMartin J. Blaser, M.D.
New York University School of Medicine
Project Title: Disappearing Gastrointestinal Microbiota in Epidemic Obesity
 

 

Structure of CIR and T cell transduction and a schematic diagram of pCLPS cassette and CIR engineered T cell constructsGeorge Coukos, M.D., Ph.D.
University of Pennsylvania
Project Title: Transformative Personalized Vascular Disrupting Cancer Immunotherapy
 

 

Enzyme-free signal amplifier based on DNA self-assemblyAndrew Ellington, Ph.D.
University of Texas, Austin
Project Title: DNA Circuits for Point-of-Care Diagnostics

 

 

Understanding Hematopoietic Neoplasias Using Humanized Mice

Richard A. Flavell, Ph.D.
Yale University School of Medicine
Madhav Dhodapkar, M.D.
Yale Cancer Center
Markus G. Manz, M.D.
University Hospital Zürich, Switzerland
Project Title: Understanding Hematopoietic Neoplasias Using Humanized Mice
 

 

Cellular enzymes called ribonucleases can cut the RNA internally (represented by scissors) while others degrade RNA from the end (represented by Pacmen)Pamela J. Green, Ph.D.
University of Delaware
Project Title: Global Analysis of the Human RNA Degradome
 

 

Dynamics of the embolus extravasation process in vivoJaime Grutzendler, M.D.
Northwestern University
Project Title: Embolus Extravasation: An Alternative Mechanism of Microvascular Recanalization
 

 

Using high-throughput DNA sequencing in conjunction with other technologies to study biophysical protein interaction behaviorAmy E. Keating, Ph.D.
Massachusetts Institute of Technology
Project Title: Very Large Datasets and New Models to Predict and Design Protein Interactions
 

 

NanoRNA-mediated priming of transcription initiation alters gene expressionBryce E. Nickels, Ph.D.
Rutgers, The State University of New Jersey, New Brunswick
Simon L. Dove. Ph.D.
Children’s Hospital Boston / Harvard Medical School
Project Title: NanoRNA-mediated Control of Gene Expression

 

Dorsal Column Stimulation as a New Therapy for Motor DisordersMiguel A. Nicolelis, M.D., Ph.D.
Duke University
Project Title: Dorsal Column Stimulation as a New Therapy for Motor Disorders
 

 

Non-Hodgkin lymphoma (NHL) cell and effects of a new therapeutic strategy that inactivates associated NHL genes, killing the lymphoma cellEugene Oltz, Ph.D. and Jacqueline Payton, M.D., Ph.D.
Washington University School of Medicine
Project Title: Targeting Epigenomic Signatures in Non-Hodgkin Lymphoma for Novel Therapeutics
 

 

Humans and mice walking on a tightrope that is attached to pillsGary A. Peltz, M.D., Ph.D.
Stanford University School of Medicine
Project Title: Human Pharmacogenetics and Human Liver Regeneration
 

 

Glia (green) ensheathing C. elegans sensory neurons (red)Shai Shaham, Ph.D.
Rockefeller University
Project Title: Glial Control of Neuronal Receptive Ending Morphology
 

 

Membrane protein reconstituted into a liposomeLiguo Wang, Ph.D.
Yale University School of Medicine
Project Title: Structure of a Membrane Protein in a Lipid Membrane: Cryo-EM Study of the HCN Channel
 

 

Development of a Universal Influenza Seasonal VaccineDavid B. Weiner, Ph.D.
University of Pennsylvania Medical School
Project Title: Development of a Universal Influenza Seasonal Vaccine
 

 

Direct Conversion of Fibroblasts into Neurons: A Novel Approach to Study Neuropsychiatric DisordersMarius Wernig, M.D., Ph.D. and Thomas C. Sudhof, M.D.
Stanford University School of Medicine
Project Title: Direct Conversion of Fibroblasts into Neurons: A Novel Approach to Study Neuropsychiatric Disorders
 

 

High-throughput in Vivo Subcellular-resolution Vertebrate Screening PlatformMehmet Fatih Yanik, Ph.D..
Massachusetts Institute of Technology
Project Title: High-throughput in Vivo Subcellular-resolution Vertebrate Screening Platform
 

 

New approach for determining brain circuitryAnthony M. Zador, M.D., Ph.D.
Cold Spring Harbor Laboratory
Project Title: High-throughput DNA Sequencing Method for Probing the Connectivity of Neural Circuits at Single-Neuron Resolution
 

 

Amacrine cells, one of which was derived from a Muller glia after retinal damageKang Zhang, M.D., Ph.D.
University of California, San Diego
Sheng Ding, Ph.D.
The Scripps Research Institute
Thomas A. Reh, Ph.D.
University of Washington
Project Title: Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Glia
 

 

A three-dimensional super-resolution fluorescence image of LacY expressed at the surface of the E. coli cellsXiawei Zhuang, Ph.D. and Xiaoliang S. Xie, Ph.D.
Harvard University
Project Title: Dynamic Cellular Architecture of Bacteria by System-Wide Super-Resolution Imaging

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