The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program is developing a library that catalogs changes that occur when different types of cells are exposed to a variety of agents that disrupt normal cellular functions, called “perturbagens.” This library integrates data across cell types, perturbagens, and measurements of cellular responses and is used by scientists to design and conduct experiments that can help us better understand normal and diseased cellular states and how to alter them.
The wealth of information created by the LINCS program is freely available to the research community and is leading to important research discoveries, including new tools for enhancing drug discovery and predicting adverse health events. You can learn how researchers use LINCS data on our Highlights page.
- Generating public datasets of five types of cellular signatures after exposure to perturbagens: changes in gene expression (transcriptomics), protein expression (proteomics), protein binding, DNA modifications (epigenomics), and cell shape and movement (imaging)
- Developing tools to optimize the accessibility, integration, and utility of LINCS data
- Disseminating information about LINCS data and tools to the broader research community
LINCS also supports a perturbation Data Coordination and Integration Center (DCIC) for data curation and integration and community outreach.
LINCS by the Numbers
This page last reviewed on December 14, 2020