For more information on the Somatic Cell Genome Editing program, visit our website at: https://commonfund.nih.gov/editing Follow this link to for a version of the video that does not include audio descriptions: https://www.youtube.com/watch?v=27o3s3TktHI Thousands of human diseases are caused by changes, or mutations, to the body's DNA. What if we could treat all these diseases by diving into our living cells to correct the mistakes? The Somatic Cell Genome Editing program aims to make that happen. Recently, researchers have made great progress in correcting DNA mutations using a technique called genome editing, and the first tests of genome editing for human diseases are starting. However, there are still some challenges to achieve safe and effective genome editing in patient cells. The Somatic Cell Genome Editing, or SCGE, program was launched by the NIH Common Fund to develop quality tools to perform safe and effective genome editing in human patients. The SCGE program will make more genome editing tools available to researchers to develop better packages to deliver the tools to the right cells, design new tests for the safety and efficacy of genome editing, and make all of the information available to the scientific community to drive future discoveries and cures for patients.

As part of the DS-I Africa Symposium, this session addressed emerging opportunities and challenges in the application of Data Science and Informatics technologies in various biomedical domains. It also highlighted some key challenges in the areas of data mining, data quality, standards for various types of data, in addition to addressing how cutting-edge data analytics, predictive modeling and Machine Learning, and methods for simulations can advance human health in Africa. Moderator: Darrell Hurt, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) Geetha Senthil, National Institute of Mental Health, NIH Panelists: Abdoulaye Banire Diallo, University of Quebec-Montreal (UQAM) Elaine Nsoesie, Boston University Geoffrey Siwo, University of Notre Dame Dina Machuve, Nelson Mandela African Institution of Science and Technology Moustapha Cisse, Google AI

In this Technical Assistance video, NIH staff provide information for potential applicants to learn more about the notice of funding opportunity (NOFO) RFA-RM-23-012: Community Partnerships to Advance Science for Society (ComPASS): Health Equity Research Hubs (UC2 Clinical Trial Optional).

NIH program and review staff discuss funding opportunity RFA-RM-23-004 and answer questions about the application and review process during this pre-application interactive Q&A webinar. This recording has audio descriptions. You can find a non audio-described version of the webinar here: https://youtu.be/qjTPAZSFLwQ

NIH program and review staff discuss funding opportunity RFA-RM-23-006 and answer questions about the application and review process during this pre-application interactive Q&A webinar. This recording has audio descriptions. You can find a non audio-described version of the webinar here: https://youtu.be/pExOK168TF0

NIH program and review staff discuss funding opportunity RFA-RM-23-007 and answer questions about the application and review process during this pre-application interactive Q&A webinar. This recording has audio descriptions. You can find a non audio-described version of the webinar here: https://youtu.be/APxnmjkkorI

NIH program and review staff discuss funding opportunity RFA-RM-23-006 and answer questions about the application and review process during this pre-application interactive Q&A webinar. You can find an audio-described version of the webinar here: https://youtu.be/bDfB8yBA43E

NIH program and review staff discuss funding opportunity RFA-RM-23-007 and answer questions about the application and review process during this pre-application interactive Q&A webinar. You can find an audio described version of the webinar here: https://youtu.be/4ZW59AIffoM

NIH program and review staff discuss funding opportunity RFA-RM-23-005 and answer questions about the application and review process during this pre-application interactive Q&A webinar. You can find an audio described version of the webinar here: https://youtu.be/dT7w_TOlEEw

NIH program and review staff discuss funding opportunity RFA-RM-23-004 and answer questions about the application and review process during this pre-application interactive Q&A webinar. An audio transcribed version of this webinar is available here: https://youtu.be/6yzWGTNi5lY

The National Institutes of Health Common Fund announced the release of a Request for Information (RFI) to obtain new ideas on NIH-wide challenges and opportunities. The Common Fund supports bold scientific programs that catalyze discovery across all biomedical and behavioral research. These programs bring together investigators and multiple NIH Institutes, Centers, and Offices to collaborate on innovate research. The NIH is requesting ideas for biomedical and behavioral research challenges and opportunities that may inform Common Fund workshops, pilot initiatives, or new programs. Do you have an idea that could push biomedical or behavioral research forward? Take part in this exciting process and submit your ideas today: https://bit.ly/Common-Fund-Ideas Thank you for your input! The request for information is now closed

The NIH Common Fund's Somatic Mosaicism across Human Tissues (SMaHT) Network aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease. We all have personal genomes that are composed of the DNA sequence we inherit and of changes to that DNA sequence that occur over time in individual cells. Somatic mosaicism refers to the post-conception changes to our DNA that lead to genetic variation among cells within an individual. We know that somatic mosaicism can lead to diseases like cancer, but we don't know how much somatic mosaicism there is in our tissues or how much it influences human biology. The goal of the SMaHT Network is to catalyze research on the impact of somatic mosaicism on human development and disease by discovering and cataloging the extent of somatic mosaicism in human tissues. Find out more at our website: https://commonfund.nih.gov/smaht And follow us on social media at: @NIH_CommonFund, #SMaHTnetwork

Part of the High-Risk, High-Reward Research program, the award supports scientists with outstanding records of creativity pursuing new research directions to develop pioneering approaches to major challenges in biomedical, social science, and behavioral research.

Part of the High-Risk, High-Reward Research program, the award supports exceptionally creative early career investigators who propose innovative, high-impact projects in the biomedical, behavioral or social sciences within the NIH mission.

Part of the High-Risk, High-Reward Research program, the award supports individuals or teams proposing transformative projects that are inherently risky and untested but have the potential to create or overturn fundamental paradigms and may require very large budgets.