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Program Snapshot

The goal of the Common Fund’s Structural Biology program was to develop novel methods to isolate large amounts of membrane proteins and determine their protein structures.

The program provided the following resources to the scientific community:

  • Laboratory Methods
  • Research Tools
  • Reference Materials
  • Database/Libraries

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Program Highlights

Researchers publish methods and tools to aid in protein structure determination
Researchers publish methods and tools to aid in protein structure determination

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Researchers Discover Structure of Opioid Receptors
Researchers Discover Structure of Opioid Receptors

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Structure of allergy-causing histamine receptor revealed
Common Fund Researchers Uncover Structure of Important Target For Drug Design

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Structure of allergy-causing histamine receptor revealed
Structure of allergy-causing histamine receptor revealed

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Program Highlight

Structural Biology grantee wins Nobel Prize in Chemistry

Dr. Brian Kobilka, grantee of the Common Fund Structural Biology program, has been awarded the 2012 Nobel Prize in Chemistry for groundbreaking studies on G-protein coupled receptors.

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G Protein Coupled Receptor (GPCR) structures solved to date through the Joint Center for Integral Membrane Protein Technologies-Complexes (JCIMPT-Complexes)

JCIMPT-Complexes

Click on the protein structure images to learn more!

In 2007, Common Fund support of pioneering methods in membrane protein production resulted in the determination of the structure of the β2 Adrenergic receptor. Since then, these methods and others have rapidly accelerated GPCR membrane protein structure determination, as shown above.

Why care about GPCRs?

S1P1 ReceptorImmune system, multiple sclerosisA2a AdenosineCardiovascular, respiratory, Parkinson's diseaseCXCR4 Chemokine recptorImmune system, HIV, cancerKappa opiodand Nociceptin FQ recptorsPain, mood, drig abuseD3 Dopamine recptorBrain signaling, schizophreniaH1 Histamine recptorImmune system allergies, inflamationAdrenergic recptorCardiovascular, asthma

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