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Funded Research

 

NIH Transformative Research Awards (R01) ​
RFA-RM-13-008​
PI Name Institution Name Title
ARNOLD, DONALD B (contact)
FRASER, SCOTT E
KESSELMAN, CARL
UNIVERSITY OF SOUTHERN CALIFORNIA Dynamic mapping of the complete synaptome using recombinant probes
GIMELBRANT, ALEXANDER DANA-FARBER CANCER INSTITUTE Mechanism and function of autosomal analog of X inactivation
JAIN, SANJAY JOHNS HOPKINS UNIVERSITY Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial Infection
KIM, DENNIS H (contact)
SCHROEDER, FRANK CLEMENS
MASSACHUSETTS INSTITUTE OF TECHNOLOGY Antimicrobial discovery from metabolomics of nematode pathogen interactions
LIM, WENDELL A UNIVERSITY OF CALIFORNIA SAN FRANCISCO Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells
MCMANUS, MICHAEL T UNIVERSITY OF CALIFORNIA SAN FRANCISCO Tracing Cell Lineages
RAFII, SHAHIN WEILL MEDICAL COLL OF CORNELL UNIV Deciphering molecular determinants of vascular heterogeneity for organ repair 
SMITH, STEPHEN J (contact)
BURNS, RANDAL
ALLEN INSTITUTE OF BRAIN SCIENCE Synaptomes of Mouse and Man

 

NIH Director's Transformative Research Awards (R01)
RFA-RM-12-017
PI Name Institution Name Title

CARNES, MOLLY L (contact)
DEVINE, PATRICIA G
FORD, CECILIA E

UNIVERSITY OF WISCONSIN-MADISON

Exploring the Science of Scientific Review

KORDING, KONRAD P. (contact)
BOYDEN, EDWARD S.
CHURCH, GEORGE M

REHABILITATION INSTITUTE OF CHICAGO

Recording neural activities onto DNA

MANDEL, GAIL (contact)
ADELMAN, JOHN P
BREHM, PAUL 
ROSENTHAL, JOSHUA J.C.

OREGON HEALTH AND SCI UNIVERSITY

Site-directed RNA editing: a new method to correct disease causing mutations

OCHOA, AUGUSTO C

LOUISIANA STATE UNIV HSC NEW ORLEANS

Metabolic approaches to treat severe viral and inflammatory diseases

RELMAN, DAVID ARNOLD (contact)
HOLMES, SUSAN P

PALO ALTO INSTITUTE FOR RES & EDU, INC.

Predicting Resilience in the Human Microbiome

TING, ALICE Y

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Spatially-resolved proteomic mapping of living cells

WANG, LIHONG

WASHINGTON UNIVERSITY

IN VIVO IMAGING OF SINGLE CIRCULATING CELLS

WYSSCORAY, TONY (contact)
RANDO, THOMAS A.

PALO ALTO INSTITUTE FOR RES & EDU, INC.

A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity

YANNOPOULOS, DEMETRI

UNIVERSITY OF MINNESOTA

Reperfusion Injury Protection Strategies During Basic Life Support

YIN, PENG

HARVARD UNIVERSITY (MEDICAL SCHOOL)

Super-resolution imaging via programmable autonomous blinking

 

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NIH Director's Transformative Research Awards (R01)
RFA-RM-12-017
PI Name Institution Name Title
ABELIOVICH, ASA COLUMBIA UNIVERSITY HEALTH SCIENCES Generation and integration of new CNS neurons by in vivo directed conversion
ALLISON, DAVID B UNIVERSITY OF ALABAMA BIRMINGHAM Energetics, Disparities, & Lifespan: A unified hypothesis
ALTSHULER, DAVID (contact)
COWAN, CHAD ALBERT
THE BROAD INSTITUTE, INC. Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
BARRES, BEN A STANFORD UNIVERSITY An Astrocytic Basis for Humanity
BLAU, HELEN M STANFORD UNIVERSITY Telomere extension using nucleoside-modified mRNA and exosomes as a novel therape
BROWN, EMERY N. (contact)
BOYDEN, EDWARD S.
SOLT, KEN
WILSON, MATTHEW A.
MASSACHUSETTS INSTITUTE OF TECHNOLOGY Redesigning General Anesthesia
CHRISTMAN, KAREN L (contact)
GIANNESCHI, NATHAN CLAUDE
UNIVERSITY OF CALIFORNIA SAN DIEGO Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
DARNELL, ROBERT B THE ROCKEFELLER UNIVERSITY Mapping the mechanisms of protein synthesis-dependent synaptic plasticity
DEISSEROTH, KARL ALEXANDER STANFORD UNIVERSITY CLARITY: fully-assembled biology
GEREAU, ROBERT W (contact)
BRUCHAS, MICHAEL R
ROGERS, JOHN
WASHINGTON UNIVERSITY Multimodal biocompatible microLED devices for diverse neuroscience applications
GLASS, CHRISTOPHER K UNIVERSITY OF CALIFORNIA SAN DIEGO Enhancer Therapy
MARASCO, PAUL CLEVELAND VA MEDICAL RESEARCH/ED/FDN Restoring upper limb movement sense to amputees; a move towards natural control of prosthetic limbs
NEWMAN, DIANNE K CALIFORNIA INSTITUTE OF TECHNOLOGY Geobiological approaches to understanding pulmonary infections in situ
SHEA, LONNIE D (contact)
BACKMAN, VADIM
NORTHWESTERN UNIVERSITY An in vivo metastasis sensor
SHEVKOPLYAS, SERGEY S TULANE UNIVERSITY OF LOUISIANA Eliminating Mediators of Toxicity from Stored Blood
STOJANOVIC, MILAN N (contact)
YAN, HAO
COLUMBIA UNIVERSITY HEALTH SCIENCES Theranostic Nano-objects: Basic Principles and Initial Applications
TUSCHL, THOMAS (contact)
OHLER, UWE
PATEL, DINSHAW J 
THE ROCKEFELLER UNIVERSITY Posttranscriptional regulation by mRNA-binding shuttling and transport proteins
WEINER, HOWARD L BRIGHAM AND WOMEN'S HOSPITAL, INC Role of the Innate Immune System in Aging and Development of Alzheimer's Disease
WISNIEWSKI, NATALIE ANN (contact)
MCSHANE, MIKE
PROFUSA, INC. Implantable multi-analyte sensors for the continuous monitoring of body chemistries
WUCHERPFENNIG, KAI W (contact)
GOTTSCHALK, STEPHEN
DANA-FARBER CANCER INSTITUTE Reprogramming of T cells for the Treatment of Melanoma

 

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NIH Director's Transformative Research Awards (R01)
RFA-RM-11-006
PI Name Institution Name Title
ABELIOVICH, ASA COLUMBIA UNIVERSITY HEALTH SCIENCES Generation and integration of new CNS neurons by in vivo directed conversion
ALLISON, DAVID B UNIVERSITY OF ALABAMA BIRMINGHAM Energetics, Disparities, & Lifespan: A unified hypothesis
ALTSHULER, DAVID (contact)
COWAN, CHAD ALBERT
THE BROAD INSTITUTE, INC. Isogenic Human Pluripotent Stem Cell-Based Models of Human Disease Mutations
BARRES, BEN A STANFORD UNIVERSITY An Astrocytic Basis for Humanity
BLAU, HELEN M STANFORD UNIVERSITY Telomere extension using nucleoside-modified mRNA and exosomes as a novel therape
BROWN, EMERY N. (contact)
BOYDEN, EDWARD S.
SOLT, KEN
WILSON, MATTHEW A.
MASSACHUSETTS INSTITUTE OF TECHNOLOGY Redesigning General Anesthesia
CHRISTMAN, KAREN L (contact)
GIANNESCHI, NATHAN CLAUDE
UNIVERSITY OF CALIFORNIA SAN DIEGO Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial Infarction
DARNELL, ROBERT B THE ROCKEFELLER UNIVERSITY Mapping the mechanisms of protein synthesis-dependent synaptic plasticity
DEISSEROTH, KARL ALEXANDER STANFORD UNIVERSITY CLARITY: fully-assembled biology
GEREAU, ROBERT W (contact)
BRUCHAS, MICHAEL R
ROGERS, JOHN
WASHINGTON UNIVERSITY Multimodal biocompatible microLED devices for diverse neuroscience applications
GLASS, CHRISTOPHER K UNIVERSITY OF CALIFORNIA SAN DIEGO Enhancer Therapy
MARASCO, PAUL CLEVELAND VA MEDICAL RESEARCH/ED/FDN Restoring upper limb movement sense to amputees; a move towards natural control of prosthetic limbs
NEWMAN, DIANNE K CALIFORNIA INSTITUTE OF TECHNOLOGY Geobiological approaches to understanding pulmonary infections in situ
SHEA, LONNIE D (contact)
BACKMAN, VADIM
NORTHWESTERN UNIVERSITY An in vivo metastasis sensor
SHEVKOPLYAS, SERGEY S TULANE UNIVERSITY OF LOUISIANA Eliminating Mediators of Toxicity from Stored Blood
STOJANOVIC, MILAN N (contact)
YAN, HAO
COLUMBIA UNIVERSITY HEALTH SCIENCES Theranostic Nano-objects: Basic Principles and Initial Applications
TUSCHL, THOMAS (contact)
OHLER, UWE
PATEL, DINSHAW J 
THE ROCKEFELLER UNIVERSITY Posttranscriptional regulation by mRNA-binding shuttling and transport proteins
WEINER, HOWARD L BRIGHAM AND WOMEN'S HOSPITAL, INC Role of the Innate Immune System in Aging and Development of Alzheimer's Disease
WISNIEWSKI, NATALIE ANN (contact)
MCSHANE, MIKE
PROFUSA, INC. Implantable multi-analyte sensors for the continuous monitoring of body chemistries
WUCHERPFENNIG, KAI W (contact)
GOTTSCHALK, STEPHEN
DANA-FARBER CANCER INSTITUTE Reprogramming of T cells for the Treatment of Melanoma

 

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NIH Common Fund Transformative Research Projects Program (R01)
RFA-RM-10-010

 

PI Name Institution Name Title
BEN-YAKAR, ADELA (contact) PIERCE-SHIMOMURA, JONATHAN T

 

UNIVERSITY OF TEXAS AUSTIN

 

High-speed opto-fluidics to screen entire nervous system in aging and disease

 

BOAHEN, KWABENA

 

STANFORD UNIVERSITY

 

Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics
GAGE, FRED H

 

SALK INSTITUTE FOR BIOLOGICAL STUDIES

 

Single-Cell Approaches to Reveal How Jumping Genes Individualize Neural Circuits

 

HARTUNG, THOMAS

 

JOHNS HOPKINS UNIVERSITY

 

Mapping the Human Toxome by Systems Toxicology
HONKANEN, RICHARD E

 

UNIVERSITY OF SOUTH ALABAMA

 

Methods to enable cholesterol catabolism in human monocyte derived macrophages
JASANOFF, ALAN

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Noninvasive imaging-based electrophysiology using microelectronic devices
KUPPER, THOMAS S

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Vaccination to generate protective tissue resident T cells

 

LECKMAN, JAMES F (contact)
WEXLER, BRUCE E.

 

YALE UNIVERSITY

 

Integrated Brain, Body and Social Intervention for ADHD

 

LICHTMAN, JEFF W (contact)
MEISTER, MARKUS
SANES, JOSHUA R
SEUNG, H SEBASTIAN

 

HARVARD UNIVERSITY

 

High Resolution Connectomics of Mammalian Neural Circuits
LIN, HENING (contact)
CERIONE, RICHARD A
WEISS, ROBERT S

 

CORNELL UNIVERSITY ITHACA

 

Succinylation and Malonylation as Novel Protein Modifications in Cancer

 

MCDEVITT, TODD C

 

GEORGIA INSTITUTE OF TECHNOLOGY

 

Stem Cell Morphogen Delivery via Engineered Biomaterials
MOOTHA, VAMSI KRISHNA

 

MASSACHUSETTS GENERAL HOSPITAL

 

Molecular prostheses for mitochondrial disorders

 

NIE, SHUMING (contact)
SINGHAL, SUNIL

 

EMORY UNIVERSITY

 

Contrast-Enhanced and Image-Guided Surgery of Lung Cancer

 

NOLTA, JAN A

 

UNIVERSITY OF CALIFORNIA DAVIS

 

Direct cell to cell transfer of microRNA for tissue repair
PAPAVASILIOU, F NINA

 

ROCKEFELLER UNIVERSITY

 

Building novel vaccines on a borrowed coat

 

PUGLISI, JOSEPH D

 

STANFORD UNIVERSITY

 

Single molecule translational profiling
ROSS, MARGARET ELIZABETH (contact)
MASON, CHRISTOPHER EDWARD

 

WEILL MEDICAL COLLEGE OF CORNELL UNIV

 

Epigenome Interactions in Complex Neurogenetic Disorders

 

 

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Roadmap Transformative Research Projects Program (R01)
RFA-RM-09-022

 

PI Name Institution Name Title
ARLOTTA, PAOLA (contact) JOUNG, J. KEITH ZHANG, FENG

 

MASSACHUSETTS GENERAL HOSPITAL

 

Genome-wide Light-inducible Tuning of Transcriptional Network Dynamic

 

BLASER, MARTIN J

 

NEW YORK UNIVERSITY SCHOOL OF MEDICINE

 

Disappearing gastrointestinal microbiota in epidemic obesity
COUKOS, GEORGE

 

UNIVERSITY OF PENNSYLVANIA

 

Transformative personalized vascular disrupting cancer immunotherapy

 

ELLINGTON, ANDREW D

 

UNIVERSITY OF TEXAS AUSTIN

 

DNA circuits for point-of-care diagnostics
FLAVELL, RICHARD A (contact) DHODAPKAR, MADHAV V

 

YALE UNIVERSITY

 

Understanding Hemotopoietic Neoplasias using Humanized Mice
GREEN, PAMELA J

 

UNIVERSITY OF DELAWARE

 

Global Analysis of the Human RNA Degradome
GRUTZENDLER, JAIME

 

NORTHWESTERN UNIVERSITY

 

Embolus extravasation: an alternative mechanism of microvascular recanalization

 

KEATING, AMY E

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Very large datasets and new models to predict and design protein interactions

 

NICKELS, BRYCE EDWARD (contact) DOVE, SIMON L

 

RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK

 

NanoRNA-mediated control of gene expression
NICOLELIS, MIGUEL A. L.

 

DUKE UNIVERSITY

 

Dorsal Column Stimulation as a New Therapy for Motor Disorders

 

OLTZ, EUGENE M. (contact) PAYTON, JACQUELINE E

 

WASHINGTON UNIVERSITY

 

Targeting Epigenomic Signatures in Non-Hodgkin Lymphoma for Novel Therapeutics
PELTZ, GARY A

 

STANFORD UNIVERSITY

 

Human Pharmacogenetics and Human Liver Regeneration

 

SHAHAM, SHAI

 

ROCKEFELLER UNIVERSITY

 

Glial control of neuronal receptive ending morphology

 

WANG, LIGUO

 

YALE UNIVERSITY

 

Structure of a membrane protein in a lipid membrane: cryo-EM study of the HCN cha
WEINER, DAVID B

 

UNIVERSITY OF PENNSYLVANIA

 

Development of a Universal Influenza Seasonal Vaccine

 

WERNIG, MARIUS (contact) SUDHOF, THOMAS C

 

STANFORD UNIVERSITY

 

Direct conversion of fibroblasts into neurons: A novel approach to study neuropsy
YANIK, MEHMET FATIH

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

High-Throughput in Vivo Subcellular-Resolution Vertebrate Screening Platform

 

ZADOR, ANTHONY M

 

COLD SPRING HARBOR LABORATORY

 

High-throughput DNA sequencing method for probing the connectivity of neural circ

 

ZHANG, KANG (contact) DING, SHENG REH, THOMAS A

 

UNIVERSITY OF CALIFORNIA SAN DIEGO

 

Regeneration of Retinal Neurons by Chemically Induced Reprogramming of Muller Gli
ZHUANG, XIAOWEI (contact) XIE, XIAOLIANG SUNNEY

 

HARVARD UNIVERSITY

 

Dynamic cellular architecture of bacteria by system-wide super-resolution imaging

 

 

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Roadmap Transformative R01 Program (R01)
RFA-RM 08-029

 

PI Name Institution Name Title
AUSUBEL, FREDERICK M

 

MASSACHUSETTS GENERAL HOSPITAL

 

Identifying novel anti-infectives by high through-put screening in whole animals
.BRETON, SYLVIE

 

MASSACHUSETTS GENERAL HOSPITAL

 

3-Dimensional modeling of basal cell function in pseudostratified epithelia
CAMARERO, JULIO A

 

UNIVERSITY OF SOUTHERN CALIFORNIA

 

Cell-based screening and selection of cyclotide-based capture reagents for protein profiling using micro-array format

 

COHEN, PINCHAS

 

UNIVERSITY OF CALIFORNIA LOS ANGELES

 

Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease
CRAVATT, BENJAMIN F. (contact);
KODADEK, THOMAS J

 

SCRIPPS RESEARCH INSTITUTE

 

Massively Parallel Identification of Protein Ligands

 

CZECH, MICHAEL P

 

UNIV OF MASSACHUSETTS MED SCH WORCESTER

 

Oral Delivery Vehicles for RNAi Therapies

 

DANUSER, GAUDENZ (contact);
HAHN, KLAUS MICHAEL

 

SCRIPPS RESEARCH INSTITUTE

 

Quantitative Imaging of Signaling Networks
DUBNAU, JOSHUA T

 

COLD SPRING HARBOR LABORATORY

 

Genome-wide regulatory network governing neuronal mRNA translation.

 

FIDOCK, DAVID ARMAND

 

COLUMBIA UNIVERSITY HEALTH SCIENCES

 

Exploiting Fatty Acid Metabolism To Cure Malaria

 

GRIFFITH, LINDA G.

 

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

 

Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems

 

HOFFMAN, ANDREW R

 

STANFORD UNIVERSITY

 

Role of Long-Range Chromatin Interactions in Genetic Disease

 

YENGAR, SRINIVAS RAVI V (contact);
HE, JOHN C
HONE, JAMES C
LOEW, LESLIE M
NEVES, SUSANA R

 

MOUNT SINAI SCHOOL OF MEDICINE OF NYU

 

Dynamics Underlying Tissue Integrity
JAFFREY, SAMIE R

 

WEILL MEDICAL COLLEGE OF CORNELL UNIV

 

Novel fluorescent sensors for simple, sensitive, and specific protein detection

 

JI, RU-RONG (contact)
SERHAN, CHARLES NICHOLAS

 

BRIGHAM AND WOMEN'S HOSPITAL

 

Resolvins, protectins, and chronic pain resolution

 

KOIDE, SHOHEI

 

UNIVERSITY OF CHICAGO

 

Rational generation of directed protein-capture reagents

 

KUO, CALVIN J

 

STANFORD UNIVERSITY

 

Three-dimensional Scaffold-based Systems for Primary Human Intestinal Culture

 

LAGASSE, ERIC

 

VA PALO ALTO HEALTH CARE SYSTEM

 

Organogenesis of Ectopic Tissue in Lymph Node
LEE, BRENDAN HL

 

BAYLOR COLLEGE OF MEDICINE

 

Argininosuccinate Lyase is an essential regulator of systemic nitric oxide production
LEE, FRANK S

 

UNIVERSITY OF PENNSYLVANIA

 

The Hydroxylprolylproteome
LEWIS, KIM

 

NORTHEASTERN UNIVERSITY

 

Super-persistent cells and the paradox of untreatable infections

 

LI, LONG-CHENG (contact);
LI, HAO

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Transcriptional Activation by Small RNA: Mechanism and Design Rules

 

LIS, JOHN T (contact);
CRAIGHEAD, HAROLD G
JIN, MOONSOO M

 

CORNELL UNIVERSITY

 

Development of High Throughput Aptamer-based Protein Capture/Detection Assays towards Comprehensive Analysis of Human Proteome

 

MACIEJEWSKI, JAROSLAW P

 

CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE

 

Viral Pathogenesis of Idiopathic Bone Marrow Failure and Immune Cytopenias
MARGOLIS, PETER ADAM (contact);
SEID, MICHAEL

 

CHILDREN'S HOSPITAL MEDICAL CTR (CINCINNATI)

 

Open Source Science: Transforming Chronic Illness Care

 

MARKOVITZ, DAVID MICHAEL

 

UNIVERSITY OF MICHIGAN AT ANN ARBOR

 

Replication of Human Endogenous Retroviruses in Modern Humans

 

MARKOWITZ, SANFORD D

 

CASE WESTERN RESERVE UNIVERSITY

 

Identifying Inborn Genetic Susceptibility to Development of Cancer Metastasis

 

MARSHALL, WALLACE

 

UNIVERSITY OF CALIFORNIA SAN FRANCISCO

 

Pattern formation & regeneration in a single cell

 

MITRA, PARTHA PRATIM

 

COLD SPRING HARBOR LABORATORY

 

The Missing Circuit: The First Brainwide Connectivity Map for Mouse
MURDOCK, DEBORAH G

 

VANDERBILT UNIVERSITY MEDICAL CENTER

 

Fatty acid signals as quorum sensing regulators of mitochondrial biogenesis

 

MURPHY, SHEILA T. (contact);
BAEZCONDE GARBANATI, LOURDES ALBERTINA
BALL-ROKEACH, SANDRA
HAILE, ROBERT WILLIAM

 

UNIVERSITY SOUTHERN CALIFORNIA

 

Transforming Cancer Knowledge, Attitudes and Behavior through Narrative

 

NISWENDER, KEVIN D (contact);
GALLI, AURELIO ANTONIO

 

VANDERBILT UNIVERSITY

 

Insulin regulation of monoamine signaling: pathway to obesity

 

PARSONNET, JULIE

 

STANFORD UNIVERSITY

 

Childhood infection and prevention of obesity
POLLACK, GERALD H

 

UNIVERSITY OF WASHINGTON

 

Unexpectedly Profound Role of Water in Biology and Medicine

 

RICE, CHARLES M. (contact);
BHATIA, SANGEETA N.

 

ROCKEFELLER UNIVERSITY

 

Modeling human hepatotropic infections in complex tissue organoids
ROBERTS, RICHARD W (contact);
SOH, HYONGSOK TOM

 

UNIVERSITY SOUTHERN CALIFORNIA

 

Polypeptide Design with Proteomic Scope via Microfluidic mRNA Display
SUKI, BELA

 

BOSTON UNIVERSITY

 

Regulatory roles of variable mechanical stimuli in cell function

 

TEWARI, MUNEESH

 

FRED HUTCHINSON CANCER RESEARCH CENTER

 

RNA as a Hormone: Systemic Signaling in Mammals via Circulating, Cell-Free Small

 

WALENSKY, LOREN D

 

DANA-FARBER CANCER INSTITUTE

 

A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactome
WILSON, ROBERT B

 

UNIVERSITY OF PENNSYLVANIA

 

Random shRNA Selection

 

WU, JOSEPH C

 

STANFORD UNIVERSITY

 

Re-Education of the Immune System for hES Cell Tolerance

 

XIE, XIAOLIANG SUNNEY

 

HARVARD UNIVERSITY

 

maging the Invisible with No Labels: A Major Opportunity in Biology and Medicine

 

ZYLKA, MARK JOHN

 

UNIVERSITY OF NORTH CAROLINA CHAPEL HILL

 

Harnessing ectonucleotidases to treat chronic pain

 

 

 

 

 

 

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