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Program Snapshot

The Common Fund's Building Blocks, Biological Pathways, and Networks program is designed to develop new technologies for studying molecular events that comprise biological pathways and networks in cells in order to catalyze studies of normal and disease-related processes. The program consists of three initiatives:

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Program Highlights

New approach allows for a greater understanding of how genomes are organized in cells 

 
Researchers discover cellular interactions that play key role in gene silencing

Each eukaryotic cell has an enclosed nucleus that houses its genome. The barrier between the nucleus and the cytoplasm is the nuclear envelope. The nuclear envelope contains channels called nuclear pores, which allow the exchange of large molecules between the nucleus and the cytoplasm. Each Nuclear Pore Complex (NPC) is, as its name implies, a sophisticated molecular machine composed of dozens of proteins, many of which have functions not well understood.

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New approach allows for a greater understanding of how genomes are organized in cells 

 
organization of genomes

Genomes, contained within chromosomes, encode the hereditary information inside each of our cells. The Human Genome Project, completed in 2003, was a large scale effort to decode the full DNA sequence from humans. While this was a milestone in modern technology, we have now come to understand that in addition to the sequence, the three-dimensional conformation of the genome plays a fundamental role in the expression of genes.

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Currently Funded National Technology Centers

 

Carnegie-Mellon University
Fluorescent Biosensors for Networks and Pathways,
Carnegie-Mellon University/University of Pittsburgh (Pittsburgh, PA) Exit Disclaimer

 

The Johns Hopkins University
Networks, Pathways and Dynamics of Lysine Modification,
The Johns Hopkins University (Baltimore, MD) Exit Disclaimer

 

Rockefeller University
New Tools for Exploring the Dynamic Interactome,
Rockefeller University (New York, NY) Exit Disclaimer

 

TCNP Pamphlet

View this Informative Pamphlet:
National Technology Centers for Networks and Pathways.Technology and Resources for Proteomics of Dynamic Systems.

 

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