4D Nucleome (logo)

Program Snapshot

Genetic material, located within the nucleus of a cell, is not randomly organized.  Although the spatial configuration of DNA and DNA-associated proteins is known to influence gene expression and cellular function, how this occurs is currently unknown. The Common Fund’s 4D Nucleome program aims to understand the principles behind the three-dimensional organization of the nucleus in space and time (the 4th dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases. 

 

program-snapshot

This page last reviewed on November 17, 2017