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Program Snapshot

Part of the Common Fund's High-Risk, High-Reward Program, the Transformative Research Award supports exceptionally innovative, unconventional, paradigm-shifting research projects that are inherently risky and untested.

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Highlights

Expanding Telomeres

Helen Blau, a 2012 awardee, developed a new technique for rapidly extending telomeres by delivering non-immunogenic modified mRNA encoding the telomerase protein TERT. The method is safe with no risk of genomic insertion and provides a crucial tool for research on extending telomeres to increase lifespans.
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Breakthrough Technique Expands the Capabilities of Microscopes

Dr. Edward Boyden (New Innovator, Pioneer, and Transformative Research Awardee) has developed a novel microscopy technique allowing high resolution imaging by enlarging the sample with material found in baby diapers in a method called expansion microscopy. Boyden is able to expand tissues to 4.5 times their normal size, enabling visualization of tiny cellular structures and proteins with ordinary microscopes.
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Discovering New Antibiotics

Dr. Kim Lewis, a 2009 awardee, used newly developed technology to discover 25 new antibiotics, including teixobactin. Teixobactin kills pathogens without encountering any detectable resistance and holds promise for treating an array of difficult to treat human infections like staphylococcus aureus (aka MRSA) and tuberculosis.
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Application Information

•  Open to individuals or teams at all career stages
•  No limits on budget requests
•  Find IC-specific guidelines for Clinical Research
•  Find an IC host for Scientific Research
•  More information
 
Application Status
FY 2015 Applications Under Review
FY 2016 RFA-RM-15-005
Due October 9, 2015

Announcements

A Scientist Deploys Light And Sound To Reveal The Brain
 

Lihong Wang (2013 awardee) is interviewed on NPR Exit Disclaimer discussing his work combining the strengths of two forms of energy, light and sound, into a single form of imaging called photoacoustics. Wang's ultimate goal is to use a combination of light and sound to solve the mysteries of the human brain.

A Colorful Look Inside the Retina
 

Sebastian Seung (2011 awardee) is featured in the NIH Director's Blog discussing his work mapping the 3D structure of individual nerve cells in the retina using EyeWire, an internet crowdsourcing game.

Karl Deisseroth Awarded Lurie Prize, Dickson Prize in Science, & Keio Medical Science Prize

 

Karl Deisseroth (2005 Pioneer and 2012 Transformative Researcher) receives the FNIH 2015 Lurie Prize Exit Disclaimer for his work on optogenetics. Dr. Desisseroth also received the Carnegie Mellon's Dickson Prize in Science Exit Disclaimer and the 2014 Keio Medical Science Prize Exit Disclaimer for his revolutionary work in optogenetics and his work on CLARITY, converting tissue into a gel linked to polymers that allow transparency and high-resolution optical access.

Xiaoliang Sunney Xie & Karl Deisseroth Win Albany Prize

 

Karl Deisseroth (2005 Pioneer and 2012 Transformative Researcher) and Xiaoliang Sunney Xie (2004 and 2013 Pioneer and 2009 and 2010 Transformative Researcher) win the prestigious Albany Prize. Exit Disclaimer Dr. Desisseroth is honored for his role in developing optogenetics. Dr. Xie is recognized for his pioneering work in single-molecule biophysical chemistry and its application to biology.

Martin Blaser Listed in "The 100 Most Influential People"

 

Martin Blaser Exit Disclaimer (2010 awardee) named in "The 100 Most Influential People" in Time magazine for his work warning the public on the consequences of antibiotic overuse.


   Agenda  •  Abstracts  •  Videocasts from Day 1Day 2, and Day 3


Save the date for the 2015 High-Risk, High-Reward Research Symposium on December 7-9 at Natcher Conference Center, NIH, Bethesda, MD!
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