Part of the Common Fund's High-Risk, High-Reward Research program, the New Innovator Award supports exceptionally creative, early-career investigators who propose innovative, high-impact projects with no preliminary data required.
Reinforcing the Circadian Clock to Gate Immune Response
Nicolas Buchler, a 2011 New Innovator, published a paper in Nature describing how two biological clocks work together to help plants maintain daily activities while dealing with intermittent demands, such as infections. The researchers further identified the gene NPR1 that links the two clocks, allowing them to work together.
Accelerating Wound Healing
Dino Di Carlo, a 2010 New Innovator, published a paper in Nature Materials showing accelerated wound healing with the use of an injectable, interconnected microporous gel scaffold from annealed microgel building blocks whose chemical and physical properties can be tailored to fit the needs of the tissue and provides a scaffold for tissue regrowth and regeneration.
Resetting the Brain to Cure Developmental Disorders
Sunil Gandhi, a 2013 New Innovator, published a paper in Neuron demonstrating a new method to reactivate plasticity in the adult brain to correct earlier developmental disorders through transplantation of embryonic inhibitory neurons. Using this method, Gandhi was able to correct amblyopia (lazy eye) in adult mice. The method will be a powerful investigative tool for understanding brain disorders and could lead to therapies for diseases like epilepsy, schizophrenia, and autism. It could also assist with conditions such as spinal cord injury or strokes.
|• Early stage investigator with no R01 or equivalent NIH grant
• Within 10 years of doctoral degree or medical internship/residency
• No preliminary data required
• Awards up to $300K per year for up to 5 years
• More information
Due October 16, 2015
|Biomarkers and Questionnaires Predict Suicide Risk
The research of Alexander Niculescu, a 2010 awardee, is featured in NIH Research Matters. Niculescu identified several genes in the blood whose activity is related to suicidal thoughts and actions in men with psychiatric disorders. Combined with app-based questionnaires measuring risk factors for suicide, researchers could predict serious suicidal thoughts in male psychiatric patients with 92% accuracy. Together, the genetic findings and questionnaires could enable clinicians to predict which patients are likely to attempt suicide.
|Kjersti Aagaard Honored with 2015 DeBakey Research Award
Kjersti Aagaard, a 2007 awardee, was honored with the Michael E. DeBakey, M.D., Excellence in Research Award by the Baylor College of Medicine. The award recognizes faculty members with significant scientific contributions to clinical or basic research.
|Pardis Sabeti Listed in "The 100 Most Influential People" in Time Magazine
2009 awardee Pardis Sabeti was recognized for her dangerous and crucial work during the Ebola epidemic in West Africa. Sabeti led a team of scientists in sequencing viral samples from infected patients to show the virus was spreading human to human. The team was eventually able to identify a single animal to human transmission that was responsible for the devastating Ebola epidemic throughout Africa.
|Andrea Armani Named Young Global Leader by the World Economic Forum
2010 awardee Andrea Armani was named a Young Global Leader by the World Economic Forum. The competition spans all fields, including business, social science, politics, engineering, and traditional sciences. Young Global Leaders are described as the planet’s top young leaders under the age of 40, who are “bold, brave, action-oriented and entrepreneurial…[who] commit both their time and talent to make the world a better place.”