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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Author Journal Name PubMedID Journal Abbreviation Publication Date
Mass Spectrometry Adduct Calculator. Blumer MR, Chang CH, Brayfindley E, Nunez JR, Colby SM, Renslow RS, Metz TO Journal of chemical information and modeling 34842435 J Chem Inf Model 2021 Dec 27
Ceramide synthase 2 deletion decreases the infectivity of HIV-1. Barklis E, Alfadhli A, Kyle JE, Bramer LM, Bloodsworth KJ, Barklis RL, Leier HC, Petty RM, Zelnik ID, Metz TO, Futerman AH, Tafesse FG The Journal of biological chemistry 33515546 J Biol Chem 2021 Jan-Jun
CyProduct: A Software Tool for Accurately Predicting the Byproducts of Human Cytochrome P450 Metabolism. Tian S, Cao X, Greiner R, Li C, Guo A, Wishart DS Journal of chemical information and modeling 34038112 J Chem Inf Model 2021 Jun 28
BioTransformer 3.0-a web server for accurately predicting metabolic transformation products. Wishart DS, Tian S, Allen D, Oler E, Peters H, Lui VW, Gautam V, Djoumbou-Feunang Y, Greiner R, Metz TO Nucleic acids research 35536252 Nucleic Acids Res 2022 Jul 5
ISiCLE: A Quantum Chemistry Pipeline for Establishing in Silico Collision Cross Section Libraries. Colby SM, Thomas DG, Nuñez JR, Baxter DJ, Glaesemann KR, Brown JM, Pirrung MA, Govind N, Teeguarden JG, Metz TO, Renslow RS Analytical chemistry 30741529 Anal Chem 2019 Apr 2
DEIMoS GUI: An Open-Source User Interface for a High-Dimensional Mass Spectrometry Data Processing Tool. Oostrom MT, Colby SM, Metz TO Journal of chemical information and modeling 38412257 J Chem Inf Model 2024 Mar 11
Introducing 'identification probability' for automated and transferable assessment of metabolite identification confidence in metabolomics and related studies. Metz TO, Chang CH, Gautam V, Anjum A, Tian S, Wang F, Colby SM, Nunez JR, Blumer MR, Edison AS, Fiehn O, Jones DP, Li S, Morgan ET, Patti GJ, Ross DH, Shapiro MR, Williams AJ, Wishart DS bioRxiv : the preprint server for biology 39131324 bioRxiv 2024 Jul 31
New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells. Couvillion SP , Zhu Y , Nagy G , Adkins JN , Ansong C , Renslow RS , Piehowski PD , Ibrahim YM , Kelly RT , Metz TO The Analyst 30507980 Analyst 2019 Jan 28
Exploring the Impacts of Conformer Selection Methods on Ion Mobility Collision Cross Section Predictions. Nielson FF, Colby SM, Thomas DG, Renslow RS, Metz TO Analytical chemistry 33606495 Anal Chem 2021 Mar 2
CFM-ID 4.0 - a web server for accurate MS-based metabolite identification. Wang F, Allen D, Tian S, Oler E, Gautam V, Greiner R, Metz TO, Wishart DS Nucleic acids research 35610037 Nucleic Acids Res 2022 Jul 5
Quantum Chemistry Calculations for Metabolomics. Borges RM, Colby SM, Das S, Edison AS, Fiehn O, Kind T, Lee J, Merrill AT, Merz KM Jr, Metz TO, Nunez JR, Tantillo DJ, Wang LP, Wang S, Renslow RS Chemical reviews 33979149 Chem Rev 2021 May 26
Correction to "Chespa: Streamlining Expansive Chemical Space Evaluation of Molecular Sets". Nuñez JR, Mcgrady M, Yesiltepe Y, Renslow RS, Metz TO Journal of chemical information and modeling 33871993 J Chem Inf Model 2021 May 24
Emerging technologies and their impact on regulatory science. Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle D, Tong L, Tong W, Eijnden-van-Raaij JVD, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W Jr Experimental biology and medicine (Maywood, N.J.) 34783606 Exp Biol Med (Maywood) 2022 Jan
Similarity Downselection: Finding the n Most Dissimilar Molecular Conformers for Reference-Free Metabolomics. Nielson FF, Kay B, Young SJ, Colby SM, Renslow RS, Metz TO Metabolites 36677030 Metabolites 2023 Jan 9
metabCombiner 2.0: Disparate Multi-Dataset Feature Alignment for LC-MS Metabolomics. Habra H, Meijer JL, Shen T, Fiehn O, Gaul DA, Fernández FM, Rempfert KR, Metz TO, Peterson KE, Evans CR, Karnovsky A Metabolites 38393017 Metabolites 2024 Feb 15
DEIMoS: An Open-Source Tool for Processing High-Dimensional Mass Spectrometry Data. Colby SM, Chang CH, Bade JL, Nunez JR, Blumer MR, Orton DJ, Bloodsworth KJ, Nakayasu ES, Smith RD, Ibrahim YM, Renslow RS, Metz TO Analytical chemistry 35430813 Anal Chem 2022 Apr 26
Who Is Metabolizing What? Discovering Novel Biomolecules in the Microbiome and the Organisms Who Make Them. Couvillion SP, Agrawal N, Colby SM, Brandvold KR, Metz TO Frontiers in cellular and infection microbiology 32850487 Front Cell Infect Microbiol 2020
CFM-ID 4.0: More Accurate ESI-MS/MS Spectral Prediction and Compound Identification. Wang F, Liigand J, Tian S, Arndt D, Greiner R, Wishart DS Analytical chemistry 34403256 Anal Chem 2021 Aug 31
Evaluation of In Silico Multifeature Libraries for Providing Evidence for the Presence of Small Molecules in Synthetic Blinded Samples. Nuñez JR, Colby SM, Thomas DG, Tfaily MM, Tolic N, Ulrich EM, Sobus JR, Metz TO, Teeguarden JG, Renslow RS Journal of chemical information and modeling 31430141 J Chem Inf Model 2019 Sep 23
A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants. Farley SE, Kyle JE, Leier HC, Bramer LM, Weinstein JB, Bates TA, Lee JY, Metz TO, Schultz C, Tafesse FG Nature communications 35715395 Nat Commun 2022 Jun 17
An initial investigation of accuracy required for the identification of small molecules in complex samples using quantum chemical calculated NMR chemical shifts. Yesiltepe Y, Govind N, Metz TO, Renslow RS Journal of cheminformatics 36138446 J Cheminform 2022 Sep 22
AutoCCS: automated collision cross-section calculation software for ion mobility spectrometry-mass spectrometry. Lee JY, Bilbao A, Conant CR, Bloodsworth KJ, Orton DJ, Zhou M, Wilson JW, Zheng X, Webb IK, Li A, Hixson KK, Fjeldsted JC, Ibrahim YM, Payne SH, Jansson C, Smith RD, Metz TO Bioinformatics (Oxford, England) 34145874 Bioinformatics 2021 Nov 18
A Practical Guide to Metabolomics Software Development. Chang HY, Colby SM, Du X, Gomez JD, Helf MJ, Kechris K, Kirkpatrick CR, Li S, Patti GJ, Renslow RS, Subramaniam S, Verma M, Xia J, Young JD Analytical chemistry 33467846 Anal Chem 2021 Feb 2
SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes. Wojcik R, Nagy G, Attah IK, Webb IK, Garimella SVB, Weitz KK, Hollerbach A, Monroe ME, Ligare MR, Nielson FF, Norheim RV, Renslow RS, Metz TO, Ibrahim YM, Smith RD Analytical chemistry 31450886 Anal Chem 2019 Sep 17
Introducing "Identification Probability" for Automated and Transferable Assessment of Metabolite Identification Confidence in Metabolomics and Related Studies. Metz TO, Chang CH, Gautam V, Anjum A, Tian S, Wang F, Colby SM, Nunez JR, Blumer MR, Edison AS, Fiehn O, Jones DP, Li S, Morgan ET, Patti GJ, Ross DH, Shapiro MR, Williams AJ, Wishart DS Analytical chemistry 39699939 Anal Chem 2025 Jan 14
Long-Term Metabolomics Reference Material. Gouveia GJ, Shaver AO, Garcia BM, Morse AM, Andersen EC, Edison AS, McIntyre LM Analytical chemistry 34156835 Anal Chem 2021 Jul 6
NMR: Unique Strengths That Enhance Modern Metabolomics Research. Edison AS, Colonna M, Gouveia GJ, Holderman NR, Judge MT, Shen X, Zhang S Analytical chemistry 33180470 Anal Chem 2021 Jan 12
CCS Predictor 2.0: An Open-Source Jupyter Notebook Tool for Filtering Out False Positives in Metabolomics. Rainey MA, Watson CA, Asef CK, Foster MR, Baker ES, Fernández FM Analytical chemistry 36473057 Anal Chem 2022 Dec 20
Sex-specificity of the C. elegans metabolome. Burkhardt RN, Artyukhin AB, Aprison EZ, Curtis BJ, Fox BW, Ludewig AH, Palomino DF, Luo J, Chaturbedi A, Panda O, Wrobel CJJ, Baumann V, Portman DS, Lee SS, Ruvinsky I, Schroeder FC Nature communications 36658169 Nat Commun 2023 Jan 19
Correlations Between LC-MS/MS-Detected Glycomics and NMR-Detected Metabolomics in Caenorhabditis elegans Development. Sheikh MO, Tayyari F, Zhang S, Judge MT, Weatherly DB, Ponce FV, Wells L, Edison AS Frontiers in molecular biosciences 31316996 Front Mol Biosci 2019
Practical Guidelines for (13)C-Based NMR Metabolomics. Edison AS, Le Guennec A, Delaglio F, Kupče Ē Methods in molecular biology (Clifton, N.J.) 31463840 Methods Mol Biol 2019
Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Wrobel CJJ, Yu J, Rodrigues PR, Ludewig AH, Curtis BJ, Cohen SM, Fox BW, O'Donnell MP, Sternberg PW, Schroeder FC Journal of the American Chemical Society 34460264 J Am Chem Soc 2021 Sep 15
Mass Spectrometry-Based Non-targeted Metabolic Profiling for Disease Detection: Recent Developments. Zang X, Monge ME, Fernández FM Trends in analytical chemistry : TRAC 32831436 Trends Analyt Chem 2019 Sep
Computer-aided drug design, quantum-mechanical methods for biological problems. Manathunga M, Götz AW, Merz KM Jr Current opinion in structural biology 35779437 Curr Opin Struct Biol 2022 Aug
Molecular Gas-Phase Conformational Ensembles. Das S, Merz KM Jr Journal of chemical information and modeling 38206321 J Chem Inf Model 2024 Feb 12
Comparison of High-Resolution Fourier Transform Mass Spectrometry Platforms for Putative Metabolite Annotation. Huang D, Bouza M, Gaul DA, Leach FE 3rd, Amster IJ, Schroeder FC, Edison AS, Fernández FM Analytical chemistry 34460220 Anal Chem 2021 Sep 14
Challenges in Identifying the Dark Molecules of Life. Monge ME, Dodds JN, Baker ES, Edison AS, Fernández FM Annual review of analytical chemistry (Palo Alto, Calif.) 30883183 Annu Rev Anal Chem (Palo Alto Calif) 2019 Jun 12
Triboelectric Nanogenerator Ion Mobility-Mass Spectrometry for In-Depth Lipid Annotation. Bouza M, Li Y, Wang AC, Wang ZL, Fernández FM Analytical chemistry 33720699 Anal Chem 2021 Apr 6
Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices. Alseekh S, Aharoni A, Brotman Y, Contrepois K, D'Auria J, Ewald J, C Ewald J, Fraser PD, Giavalisco P, Hall RD, Heinemann M, Link H, Luo J, Neumann S, Nielsen J, Perez de Souza L, Saito K, Sauer U, Schroeder FC, Schuster S, Siuzdak G, Skirycz A, Sumner LW, Snyder MP, Tang H, Tohge T, Wang Y, Wen W, Wu S, Xu G, Zamboni N, Fernie AR Nature methods 34239102 Nat Methods 2021 Jul
AutoGraph: Autonomous Graph-Based Clustering of Small-Molecule Conformations. Tanemura KA, Das S, Merz KM Jr Journal of chemical information and modeling 33780248 J Chem Inf Model 2021 Apr 26
Culture and Assay of Large-Scale Mixed-Stage Caenorhabditis elegans Populations. Shaver AO, Gouveia GJ, Kirby PS, Andersen EC, Edison AS Journal of visualized experiments : JoVE 34028439 J Vis Exp 2021 May 5
Role of UDP-Glycosyltransferase (ugt) Genes in Detoxification and Glycosylation of 1-Hydroxyphenazine (1-HP) in Caenorhabditis elegans. Asif MZ, Nocilla KA, Ngo L, Shah M, Smadi Y, Hafeez Z, Parnes M, Manson A, Glushka JN, Leach FE 3rd, Edison AS Chemical research in toxicology 38488606 Chem Res Toxicol 2024 Apr 15
Rapid and Automated Ab Initio Metabolite Collisional Cross Section Prediction from SMILES Input. Das S, Dinpazhoh L, Tanemura KA, Merz KM Jr Journal of chemical information and modeling 37548575 J Chem Inf Model 2023 Aug 28
An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics. Shaver AO, Garcia BM, Gouveia GJ, Morse AM, Liu Z, Asef CK, Borges RM, Leach FE 3rd, Andersen EC, Amster IJ, Fernández FM, Edison AS, McIntyre LM Frontiers in molecular biosciences 36438654 Front Mol Biosci 2022
Eliminating the Deadwood: A Machine Learning Model for CCS Knowledge-Based Conformational Focusing for Lipids. Keng M, Merz KM Jr Journal of chemical information and modeling 39378407 J Chem Inf Model 2024 Oct 28
International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis. Thompson JW, Adams KJ, Adamski J, Asad Y, Borts D, Bowden JA, Byram G, Dang V, Dunn WB, Fernandez F, Fiehn O, Gaul DA, Hühmer AF, Kalli A, Koal T, Koeniger S, Mandal R, Meier F, Naser FJ, O'Neil D, Pal A, Patti GJ, Pham-Tuan H, Prehn C, Raynaud FI, Shen T, Southam AD, St John-Williams L, Sulek K, Vasilopoulou CG, Viant M, Winder CL, Wishart D, Zhang L, Zheng J, Moseley MA Analytical chemistry 31638379 Anal Chem 2019 Nov 19
Sub-nanoliter metabolomics via mass spectrometry to characterize volume-limited samples. Li Y, Bouza M, Wu C, Guo H, Huang D, Doron G, Temenoff JS, Stecenko AA, Wang ZL, Fernández FM Nature communications 33159052 Nat Commun 2020 Nov 6
Metabolite Structure Assignment Using In Silico NMR Techniques. Das S, Edison AS, Merz KM Jr Analytical chemistry 32608974 Anal Chem 2020 Aug 4
In Silico Collision Cross Section Calculations to Aid Metabolite Annotation. Das S, Tanemura KA, Dinpazhoh L, Keng M, Schumm C, Leahy L, Asef CK, Rainey M, Edison AS, Fernández FM, Merz KM Jr Journal of the American Society for Mass Spectrometry 35378036 J Am Soc Mass Spectrom 2022 May 4
GAIT-GM integrative cross-omics analyses reveal cholinergic defects in a C. elegans model of Parkinson's disease. McIntyre LM, Huertas F, Morse AM, Kaletsky R, Murphy CT, Kalia V, Miller GW, Moskalenko O, Conesa A, Mor DE Scientific reports 35228596 Sci Rep 2022 Feb 28
The metabolome as a biomarker of aging in Drosophila melanogaster. Zhao X, Golic FT, Harrison BR, Manoj M, Hoffman EV, Simon N, Johnson R, MacCoss MJ, McIntyre LM, Promislow DEL Aging cell 35019203 Aging Cell 2022 Feb
NMR and Metabolomics-A Roadmap for the Future. Wishart DS, Cheng LL, Copié V, Edison AS, Eghbalnia HR, Hoch JC, Gouveia GJ, Pathmasiri W, Powers R, Schock TB, Sumner LW, Uchimiya M Metabolites 35893244 Metabolites 2022 Jul 23
Unknown Metabolite Identification Using Machine Learning Collision Cross-Section Prediction and Tandem Mass Spectrometry. Asef CK, Rainey MA, Garcia BM, Gouveia GJ, Shaver AO, Leach FE 3rd, Morse AM, Edison AS, McIntyre LM, Fernández FM Analytical chemistry 36595469 Anal Chem 2023 Jan 17
Crystal-C: A Computational Tool for Refinement of Open Search Results. Chang HY, Kong AT, da Veiga Leprevost F, Avtonomov DM, Haynes SE, Nesvizhskii AI Journal of proteome research 32338005 J Proteome Res 2020 Jun 5
Implementing the MSFragger Search Engine as a Node in Proteome Discoverer. Chang HY, Haynes SE, Yu F, Nesvizhskii AI Journal of proteome research 36475762 J Proteome Res 2023 Feb 3
Modifying Chromatography Conditions for Improved Unknown Feature Identification in Untargeted Metabolomics. Anderson BG, Raskind A, Habra H, Kennedy RT, Evans CR Analytical chemistry 34794310 Anal Chem 2021 Dec 7
The unknown lipids project: harmonized methods improve compound identification and data reproducibility in an inter-laboratory untargeted lipidomics study. Shen T, Conway C, Rempfert KR, Kyle JE, Colby SM, Gaul DA, Habra H, Kong F, Bloodsworth KJ, Allen D, Evans BS, Du X, Fernandez FM, Metz TO, Fiehn O, Evans CR bioRxiv : the preprint server for biology 36778509 bioRxiv 2023 Feb 3
Untargeted Metabolomics Differentiates l-Carnitine Treated Septic Shock 1-Year Survivors and Nonsurvivors. Evans CR, Karnovsky A, Puskarich MA, Michailidis G, Jones AE, Stringer KA Journal of proteome research 30895797 J Proteome Res 2019 May 3
metabCombiner: Paired Untargeted LC-HRMS Metabolomics Feature Matching and Concatenation of Disparately Acquired Data Sets. Habra H, Kachman M, Bullock K, Clish C, Evans CR, Karnovsky A Analytical chemistry 33724799 Anal Chem 2021 Mar 30
Compound Identification Strategies in Mass Spectrometry-Based Metabolomics and Pharmacometabolomics. Hissong R, Evans KR, Evans CR Handbook of experimental pharmacology 36409330 Handb Exp Pharmacol 2023
In-Depth Chemical Analysis of the Brain Extracellular Space Using In Vivo Microdialysis with Liquid Chromatography-Tandem Mass Spectrometry. Anderson BG, Popov P, Cicali AR, Nwamba A, Evans CR, Kennedy RT Analytical chemistry 39360623 Anal Chem 2024 Oct 15
Metabolome-wide association study of flavorant vanillin exposure in bronchial epithelial cells reveals disease-related perturbations in metabolism. Smith MR, Jarrell ZR, Orr M, Liu KH, Go YM, Jones DP Environment international 33360165 Environ Int 2021 Feb
Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria. Mor DE, Sohrabi S, Kaletsky R, Keyes W, Tartici A, Kalia V, Miller GW, Murphy CT Proceedings of the National Academy of Sciences of the United States of America 33024014 Proc Natl Acad Sci U S A 2020 Oct 20
Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors. Hu X, Saunders N, Safley S, Smith MR, Liang Y, Tran V, Sharma J, Jones DP, Weber CJ Surgery 32771296 Surgery 2021 Jan
Associations of Benzo(ghi)perylene and Heptachlorodibenzo-p-dioxin in Serum of Service Personnel Deployed to Balad, Iraq, and Bagram, Afghanistan Correlates With Perturbed Amino Acid Metabolism in Human Lung Fibroblasts. Smith MR, Woeller CF, Uppal K, Thatcher TH, Walker DI, Hopke PK, Rohrbeck P, Mallon TM, Krahl PL, Utell MJ, Go YM, Jones DP Journal of occupational and environmental medicine 31800449 J Occup Environ Med 2019 Dec
The Essential Toolbox of Data Science: Python, R, Git, and Docker. Pittard WS, Li S Methods in molecular biology (Clifton, N.J.) 31953823 Methods Mol Biol 2020
Metabolomic Profiling After a Meal Shows Greater Changes and Lower Metabolic Flexibility in Cardiometabolic Diseases. Yu EA, Yu T, Jones DP, Ramirez-Zea M, Stein AD Journal of the Endocrine Society 33134764 J Endocr Soc 2020 Nov 1
A scalable workflow to characterize the human exposome. Hu X, Walker DI, Liang Y, Smith MR, Orr ML, Juran BD, Ma C, Uppal K, Koval M, Martin GS, Neujahr DC, Marsit CJ, Go YM, Pennell KD, Miller GW, Lazaridis KN, Jones DP Nature communications 34552080 Nat Commun 2021 Sep 22
The metabolome: A key measure for exposome research in epidemiology. Walker DI, Valvi D, Rothman N, Lan Q, Miller GW, Jones DP Current epidemiology reports 31828002 Curr Epidemiol Rep 2019
Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum. Hu X, Li S, Cirillo P, Krigbaum N, Tran V, Ishikawa T, La Merrill MA, Jones DP, Cohn B Reproductive toxicology (Elmsford, N.Y.) 31102720 Reprod Toxicol 2020 Mar
Cruciferous vegetables (Brassica oleracea) confer cytoprotective effects in Drosophila intestines. Lyles JT, Luo L, Liu K, Jones DP, Jones RM, Quave CL Gut microbes 33966605 Gut Microbes 2021 Jan-Dec
Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery. Chung MK, Rappaport SM, Wheelock CE, Nguyen VK, van der Meer TP, Miller GW, Vermeulen R, Patel CJ Environmental health perspectives 34435882 Environ Health Perspect 2021 Aug
The exposome and liver disease - how environmental factors affect liver health. Barouki R, Samson M, Blanc EB, Colombo M, Zucman-Rossi J, Lazaridis KN, Miller GW, Coumoul X Journal of hepatology 36889360 J Hepatol 2023 Aug
High-Throughput Production of Diverse Xenobiotic Metabolites with Cytochrome P450-Transduced Huh7 Hepatoma Cell Lines. Lee CM, Liu KH, Singer G, Miller GW, Li S, Jones DP, Morgan ET Drug metabolism and disposition: the biological fate of chemicals 35752443 Drug Metab Dispos 2022 Sep
Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study. Goodrich JA, Walker DI, He J, Lin X, Baumert BO, Hu X, Alderete TL, Chen Z, Valvi D, Fuentes ZC, Rock S, Wang H, Berhane K, Gilliland FD, Goran MI, Jones DP, Conti DV, Chatzi L Environmental health perspectives 36821578 Environ Health Perspect 2023 Feb
Integrating the exposome into a multi-omic research framework. Miller GW Exposome 37538530 Exposome 2021
Effect of altered production and storage of dopamine on development and behavior in C. elegans. Lee I, Knickerbocker AC, Depew CR, Martin E, Dicent J, Miller GW, Bucher ML bioRxiv : the preprint server for biology 37873331 bioRxiv 2023 Oct 10
Exposure to perfluoroalkyl substances and longitudinal changes in bone mineral density in adolescents and young adults: A multi-cohort study. Beglarian E, Costello E, Walker DI, Wang H, Alderete TL, Chen Z, Valvi D, Baumert BO, Rock S, Rubbo B, Aung MT, Gilliland FD, Goran MI, Jones DP, McConnell R, Eckel SP, Conti DV, Goodrich JA, Chatzi L Environmental research 38061983 Environ Res 2024 Mar 1
Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's. Li S, Cirillo P, Hu X, Tran V, Krigbaum N, Yu S, Jones DP, Cohn B Reproductive toxicology (Elmsford, N.Y.) 31299210 Reprod Toxicol 2020 Mar
Omics Integration for Mitochondria Systems Biology. Hu X, Go YM, Jones DP Antioxidants & redox signaling 31891667 Antioxid Redox Signal 2020 Apr 20
Plasma concentrations of lipophilic persistent organic pollutants and glucose homeostasis in youth populations. Baumert BO, Goodrich JA, Hu X, Walker DI, Alderete TL, Chen Z, Valvi D, Rock S, Berhane K, Gilliland FD, Goran MI, Jones DP, Conti DV, Chatzi L Environmental research 35447156 Environ Res 2022 Sep
A vision for exposome epidemiology: The pregnancy exposome in relation to breast cancer in the Child Health and Development Studies. Jones DP, Cohn BA Reproductive toxicology (Elmsford, N.Y.) 32197999 Reprod Toxicol 2020 Mar
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, Murphy MP, Yamamoto M, Winterbourn C Nature reviews. Molecular cell biology 35190722 Nat Rev Mol Cell Biol 2022 Jul
Differences in plasma metabolites related to Alzheimer's disease, APOE ε4 status, and ethnicity. Vardarajan B, Kalia V, Manly J, Brickman A, Reyes-Dumeyer D, Lantigua R, Ionita-Laza I, Jones DP, Miller GW, Mayeux R Alzheimer's & dementia (New York, N. Y.) 32377558 Alzheimers Dement (N Y) 2020
Macronutrient, Energy, and Bile Acid Metabolism Pathways Altered Following a Physiological Meal Challenge, Relative to Fasting, among Guatemalan Adults. Yu EA, Yu T, Jones DP, Martorell R, Ramirez-Zea M, Stein AD The Journal of nutrition 32597983 J Nutr 2020 Aug 1
Distribution of phytochelatins, metal-binding compounds, in plant foods: A survey of commonly consumed fruits, vegetables, grains and legumes. Dennis KK, Liu KH, Uppal K, Go YM, Jones DP Food chemistry 32950899 Food Chem 2021 Mar 1
Air pollution and decreased bone mineral density among Women's Health Initiative participants. Prada D, Crandall CJ, Kupsco A, Kioumourtzoglou MA, Stewart JD, Liao D, Yanosky JD, Ramirez A, Wactawski-Wende J, Shen Y, Miller G, Ionita-Laza I, Whitsel EA, Baccarelli AA EClinicalMedicine 36820096 EClinicalMedicine 2023 Mar
High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage. Lai Y, Koelmel JP, Walker DI, Price EJ, Papazian S, Manz KE, Castilla-Fernández D, Bowden JA, Nikiforov V, David A, Bessonneau V, Amer B, Seethapathy S, Hu X, Lin EZ, Jbebli A, McNeil BR, Barupal D, Cerasa M, Xie H, Kalia V, Nandakumar R, Singh R, Tian Z, Gao P, Zhao Y, Froment J, Rostkowski P, Dubey S, Coufalíková K, Seličová H, Hecht H, Liu S, Udhani HH, Restituito S, Tchou-Wong KM, Lu K, Martin JW, Warth B, Godri Pollitt KJ, Klánová J, Fiehn O, Metz TO, Pennell KD, Jones DP, Miller GW Environmental science & technology 38984754 Environ Sci Technol 2024 Jul 23
Exposome: a new field, a new journal. Miller GW Exposome 37538531 Exposome 2021
Postprandial Metabolite Profiles and Risk of Prediabetes in Young People: A Longitudinal Multicohort Study. Goodrich JA, Wang H, Walker DI, Lin X, Hu X, Alderete TL, Chen Z, Valvi D, Baumert BO, Rock S, Berhane K, Gilliland FD, Goran MI, Jones DP, Conti DV, Chatzi L Diabetes care 37971952 Diabetes Care 2024 Jan 1
Effect of altered production and storage of dopamine on development and behavior in C. elegans. Lee I, Knickerbocker AC, Depew CR, Martin EL, Dicent J, Miller GW, Bucher ML Frontiers in toxicology 39219718 Front Toxicol 2024
Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog. Weinberg J, Liu KH, Lee CM, Crandall WJ, Cuevas AR, Druzak SA, Morgan ET, Jarrell ZR, Ortlund EA, Martin GS, Singer G, Strobel FH, Go YM, Jones DP The Journal of biological chemistry 39675709 J Biol Chem 2025 Jan
The Exposome and Toxicology: A Win-Win Collaboration. Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D Toxicological sciences : an official journal of the Society of Toxicology 34878125 Toxicol Sci 2022 Feb 28
Large scale enzyme based xenobiotic identification for exposomics. Liu KH, Lee CM, Singer G, Bais P, Castellanos F, Woodworth MH, Ziegler TR, Kraft CS, Miller GW, Li S, Go YM, Morgan ET, Jones DP Nature communications 34521839 Nat Commun 2021 Sep 14
Metabolomics as a Truly Translational Tool for Precision Medicine. Schmidt JC, Dougherty BV, Beger RD, Jones DP, Schmidt MA, Mattes WB International journal of toxicology 34514887 Int J Toxicol 2021 Oct
Phytochelatin database: a resource for phytochelatin complexes of nutritional and environmental metals. Dennis KK, Uppal K, Liu KH, Ma C, Liang B, Go YM, Jones DP Database : the journal of biological databases and curation 31267134 Database (Oxford) 2019 Jan 1
Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy. Sumarriva K, Uppal K, Ma C, Herren DJ, Wang Y, Chocron IM, Warden C, Mitchell SL, Burgess LG, Goodale MP, Osborn MP, Ferreira AJ, Law JC, Cherney EF, Jones DP, Brantley MA Jr Investigative ophthalmology & visual science 31323682 Invest Ophthalmol Vis Sci 2019 Jul 1
A Bioinformatics Primer to Data Science, with Examples for Metabolomics. Pittard WS, Villaveces CK, Li S Methods in molecular biology (Clifton, N.J.) 31953822 Methods Mol Biol 2020
Network-Based Approaches for Multi-omics Integration. Zhou G, Li S, Xia J Methods in molecular biology (Clifton, N.J.) 31953831 Methods Mol Biol 2020
The exposome and health: Where chemistry meets biology. Vermeulen R, Schymanski EL, Barabási AL, Miller GW Science (New York, N.Y.) 31974245 Science 2020 Jan 24
Seminar: Functional Exposomics and Mechanisms of Toxicity-Insights from Model Systems and NAMs. Lai Y, Ay M, Hospital CD, Miller GW, Sarkar S Environmental health perspectives 39230330 Environ Health Perspect 2024 Sep
Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach. Valvi D, Walker DI, Inge T, Bartell SM, Jenkins T, Helmrath M, Ziegler TR, La Merrill MA, Eckel SP, Conti D, Liang Y, Jones DP, McConnell R, Chatzi L Environment international 32683211 Environ Int 2020 Oct
Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum. Hu X, Li S, Cirillo PM, Krigbaum NY, Tran V, Jones DP, Cohn BA Reproductive toxicology (Elmsford, N.Y.) 31121237 Reprod Toxicol 2019 Aug
Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics. Liu KH, Nellis M, Uppal K, Ma C, Tran V, Liang Y, Walker DI, Jones DP Analytical chemistry 32490663 Anal Chem 2020 Jul 7
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen. Liu KH, Owens JA, Saeedi B, Cohen CE, Bellissimo MP, Naudin C, Darby T, Druzak S, Maner-Smith K, Orr M, Hu X, Fernandes J, Camacho MC, Hunter-Chang S, VanInsberghe D, Ma C, Ganesh T, Yeligar SM, Uppal K, Go YM, Alvarez JA, Vos MB, Ziegler TR, Woodworth MH, Kraft CS, Jones RM, Ortlund E, Neish AS, Jones DP Nature metabolism 34931082 Nat Metab 2021 Dec
Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: A multicohort study. Hampson HE, Costello E, Walker DI, Wang H, Baumert BO, Valvi D, Rock S, Jones DP, Goran MI, Gilliland FD, Conti DV, Alderete TL, Chen Z, Chatzi L, Goodrich JA Environment international 38316574 Environ Int 2024 Mar
17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males. Garratt M, Leander D, Pifer K, Bower B, Herrera JJ, Day SM, Fiehn O, Brooks SV, Miller RA Aging cell 30740872 Aging Cell 2019 Apr
Zika Virus Infection Results in Biochemical Changes Associated With RNA Editing, Inflammatory and Antiviral Responses in Aedes albopictus. Onyango MG, Attardo GM, Kelly ET, Bialosuknia SM, Stout J, Banker E, Kuo L, Ciota AT, Kramer LD Frontiers in microbiology 33133033 Front Microbiol 2020
The Emerging and Diverse Roles of Bis(monoacylglycero) Phosphate Lipids in Cellular Physiology and Disease. Showalter MR, Berg AL, Nagourney A, Heil H, Carraway KL 3rd, Fiehn O International journal of molecular sciences 33137979 Int J Mol Sci 2020 Oct 29
JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding. DiTacchio KA, Kalinowska D, Saran AR, Byrne A, Vollmers C, DiTacchio L Cell reports 32460011 Cell Rep 2020 May 26
Leucoselect Phytosome Modulates Serum Eicosapentaenoic Acid, Docosahexaenoic Acid, and Prostaglandin E3 in a Phase I Lung Cancer Chemoprevention Study. Mao JT, Xue B, Fan S, Neis P, Qualls C, Massie L, Fiehn O Cancer prevention research (Philadelphia, Pa.) 33707173 Cancer Prev Res (Phila) 2021 Jun
Glutathione deficiency decreases lipid droplet stores and increases reactive oxygen species in mouse oocytes†. Malott KF, Reshel S, Ortiz L, Luderer U Biology of reproduction 35238901 Biol Reprod 2022 Jun 13
Predicting in silico electron ionization mass spectra using quantum chemistry. Wang S, Kind T, Tantillo DJ, Fiehn O Journal of cheminformatics 33372633 J Cheminform 2020 Oct 20
Application of Machine Learning to Metabolomic Profile Characterization in Glioblastoma Patients Undergoing Concurrent Chemoradiation. Aboud O, Liu YA, Fiehn O, Brydges C, Fragoso R, Lee HS, Riess J, Hodeify R, Bloch O Metabolites 36837918 Metabolites 2023 Feb 17
LibGen: Generating High Quality Spectral Libraries of Natural Products for EAD-, UVPD-, and HCD-High Resolution Mass Spectrometers. Kong F, Keshet U, Shen T, Rodriguez E, Fiehn O Analytical chemistry 37939222 Anal Chem 2023 Nov 21
Denoising Search doubles the number of metabolite and exposome annotations in human plasma using an Orbitrap Astral mass spectrometer. Kong F, Shen T, Li Y, Bashar A, Bird SS, Fiehn O Research square 39108483 Res Sq 2024 Jul 25
SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice. Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM Physiological reports 35611788 Physiol Rep 2022 May
Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice. Graham ZA, Siedlik JA, Toro CA, Harlow L, Cardozo CP International journal of environmental research and public health 37623175 Int J Environ Res Public Health 2023 Aug 17
Differences in the Stool Metabolome between Vegans and Omnivores: Analyzing the NIST Stool Reference Material. Cumeras R, Shen T, Valdiviez L, Tippins Z, Haffner BD, Fiehn O Metabolites 37623865 Metabolites 2023 Aug 7
SMetaS: A Sample Metadata Standardizer for Metabolomics. Bremer PL, Fiehn O Metabolites 37623884 Metabolites 2023 Aug 12
Automatic Assignment of Molecular Ion Species to Elemental Formulas in Gas Chromatography/Methane Chemical Ionization Accurate Mass Spectrometry. Wang S, Valdiviez L, Ye H, Fiehn O Metabolites 37623905 Metabolites 2023 Aug 19
A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium. Barupal DK, Zhang Y, Shen T, Fan S, Roberts BS, Fitzgerald P, Wancewicz B, Valdiviez L, Wohlgemuth G, Byram G, Choy YY, Haffner B, Showalter MR, Vaniya A, Bloszies CS, Folz JS, Kind T, Flenniken AM, McKerlie C, Nutter LMJ, Lloyd KC, Fiehn O Metabolites 31121816 Metabolites 2019 May 22
Rapid LC-MS/MS quantification of cancer related acetylated polyamines in human biofluids. DeFelice BC, Fiehn O Talanta 30683386 Talanta 2019 May 1
Structure Annotation of All Mass Spectra in Untargeted Metabolomics. Blaženović I, Kind T, Sa MR, Ji J, Vaniya A, Wancewicz B, Roberts BS, Torbašinović H, Lee T, Mehta SS, Showalter MR, Song H, Kwok J, Jahn D, Kim J, Fiehn O Analytical chemistry 30608141 Anal Chem 2019 Feb 5
Serum and urinary metabolomics and outcomes in cirrhosis. Bajaj JS, Fan S, Thacker LR, Fagan A, Gavis E, White MB, Heuman DM, Fuchs M, Fiehn O PloS one 31560724 PLoS One 2019
Inborn Errors of Metabolism in the Era of Untargeted Metabolomics and Lipidomics. Ismail IT, Showalter MR, Fiehn O Metabolites 31640247 Metabolites 2019 Oct 21
Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification. Li Y, Kind T, Folz J, Vaniya A, Mehta SS, Fiehn O Nature methods 34857935 Nat Methods 2021 Dec
Effects of Lean Pork on Microbiota and Microbial-Metabolite Trimethylamine-N-Oxide: A Randomized Controlled Non-Inferiority Feeding Trial Based on the Dietary Guidelines for Americans. Dhakal S, Moazzami Z, Perry C, Dey M Molecular nutrition & food research 35182101 Mol Nutr Food Res 2022 May
Preclinical translation of exosomes derived from mesenchymal stem/stromal cells. Elahi FM, Farwell DG, Nolta JA, Anderson JD Stem cells (Dayton, Ohio) 31381842 Stem Cells 2020 Jan
Quantum Chemical Prediction of Electron Ionization Mass Spectra of Trimethylsilylated Metabolites. Wang S, Kind T, Bremer PL, Tantillo DJ, Fiehn O Analytical chemistry 35006668 Anal Chem 2022 Jan 25
Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu. Valdés A, Lucio-Cazaña FJ, Castro-Puyana M, García-Pastor C, Fiehn O, Marina ML Scientific reports 33658594 Sci Rep 2021 Mar 3
Methods to capture proteomic and metabolomic signatures from cerebrospinal fluid and serum of healthy individuals. Lilley LM, Sanche S, Moore SC, Salemi MR, Vu D, Iyer S, Hengartner NW, Mukundan H Scientific reports 35922450 Sci Rep 2022 Aug 3
Lipidomics of cyclophosphamide 4-hydroxylation in patients receiving post-transplant cyclophosphamide. Navarro SL, Zheng Z, Randolph TW, Nakamura R, Sandmaier BM, Hockenbery D, McCune JS Clinical and translational science 36088654 Clin Transl Sci 2022 Nov
Pharmacometabonomic association of cyclophosphamide 4-hydroxylation in hematopoietic cell transplant recipients. McCune JS, Nakamura R, O'Meally D, Randolph TW, Sandmaier BM, Karolak A, Hockenbery D, Navarro SL Clinical and translational science 35106927 Clin Transl Sci 2022 May
The BinDiscover database: a biology-focused meta-analysis tool for 156,000 GC-TOF MS metabolome samples. Bremer PL, Wohlgemuth G, Fiehn O Journal of cheminformatics 37475020 J Cheminform 2023 Jul 20
Flash entropy search to query all mass spectral libraries in real time. Li Y, Fiehn O Nature methods 37735567 Nat Methods 2023 Oct
Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment. Aboud O, Liu Y, Dahabiyeh L, Abuaisheh A, Li F, Aboubechara JP, Riess J, Bloch O, Hodeify R, Tagkopoulos I, Fiehn O Biomedicines 37626757 Biomedicines 2023 Aug 13
Impact of Protonation Sites on Collision-Induced Dissociation-MS/MS Using CIDMD Quantum Chemistry Modeling. Lee J, Tantillo DJ, Wang LP, Fiehn O Journal of chemical information and modeling 39329341 J Chem Inf Model 2024 Oct 14
Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy. Vaniya A, Karlstaedt A, Gulkok D, Thottakara T, Liu Y, Fan S, Eades H, Vakrou S, Fukunaga R, Vernon HJ, Fiehn O, Roselle Abraham M Journal of molecular and cellular cardiology plus 39430912 J Mol Cell Cardiol Plus 2024 Jun
Environmental Tobacco Smoke Alters Metabolic Systems in Adult Rats. Barupal DK, Pinkerton KE, Hood C, Kind T, Fiehn O Chemical research in toxicology 27788581 Chem Res Toxicol 2016 Nov 21
Evaluating the Accuracy of the QCEIMS Approach for Computational Prediction of Electron Ionization Mass Spectra of Purines and Pyrimidines. Lee J, Kind T, Tantillo DJ, Wang LP, Fiehn O Metabolites 35050190 Metabolites 2022 Jan 12
Plasma Metabolite Profiles Following Consumption of Animal Protein and Soybean-Based Diet in Hypercholesterolemic Postmenopausal Women. Huang NK, Matthan NR, Matuszek G, Lichtenstein AH Metabolites 35323651 Metabolites 2022 Feb 25
Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium. Hook V, Kind T, Podvin S, Palazoglu M, Tran C, Toneff T, Samra S, Lietz C, Fiehn O ACS chemical neuroscience 30698015 ACS Chem Neurosci 2019 Mar 20
Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation. Showalter MR, Wancewicz B, Fiehn O, Archard JA, Clayton S, Wagner J, Deng P, Halmai J, Fink KD, Bauer G, Fury B, Perotti NH, Apperson M, Butters J, Belafsky P, Farwell G, Kuhn M, Nolta JA, Anderson JD Biochemical and biophysical research communications 30926165 Biochem Biophys Res Commun 2019 May 14
Retip: Retention Time Prediction for Compound Annotation in Untargeted Metabolomics. Bonini P, Kind T, Tsugawa H, Barupal DK, Fiehn O Analytical chemistry 32390414 Anal Chem 2020 Jun 2
Exosomes in disease and regeneration: biological functions, diagnostics, and beneficial effects. Lin Y, Anderson JD, Rahnama LMA, Gu SV, Knowlton AA American journal of physiology. Heart and circulatory physiology 32986962 Am J Physiol Heart Circ Physiol 2020 Dec 1
Comparing Stable Isotope Enrichment by Gas Chromatography with Time-of-Flight, Quadrupole Time-of-Flight, and Quadrupole Mass Spectrometry. Zhang Y, Gao B, Valdiviez L, Zhu C, Gallagher T, Whiteson K, Fiehn O Analytical chemistry 33434014 Anal Chem 2021 Feb 2
Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort. Rahman ML, Feng YA, Fiehn O, Albert PS, Tsai MY, Zhu Y, Wang X, Tekola-Ayele F, Liang L, Zhang C BMJ open diabetes research & care 33674279 BMJ Open Diabetes Res Care 2021 Mar
Resistant starch type-4 intake alters circulating bile acids in human subjects. Dhakal S, Dey M Frontiers in nutrition 36337613 Front Nutr 2022
Denoising Autoencoder Normalization for Large-Scale Untargeted Metabolomics by Gas Chromatography-Mass Spectrometry. Zhang Y, Fan S, Wohlgemuth G, Fiehn O Metabolites 37623887 Metabolites 2023 Aug 13
Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines. Zhang Y, Barupal DK, Fan S, Gao B, Zhu C, Flenniken AM, McKerlie C, Nutter LMJ, Lloyd KCK, Fiehn O Metabolites 37623890 Metabolites 2023 Aug 15
How Well Can We Predict Mass Spectra from Structures? Benchmarking Competitive Fragmentation Modeling for Metabolite Identification on Untrained Tandem Mass Spectra. Bremer PL, Vaniya A, Kind T, Wang S, Fiehn O Journal of chemical information and modeling 36043939 J Chem Inf Model 2022 Sep 12
Beyond the Ground State: Predicting Electron Ionization Mass Spectra Using Excited-State Molecular Dynamics. Wang S, Kind T, Bremer PL, Tantillo DJ, Fiehn O Journal of chemical information and modeling 36107950 J Chem Inf Model 2022 Sep 26
Assessing the impact of boldine on the gastrocnemius using multiomics profiling at 7 and 28 days post-complete spinal cord injury in young male mice. Potter LA, Toro CA, Harlow L, Lavin KM, Cardozo CP, Wende AR, Graham ZA Physiological genomics 37125768 Physiol Genomics 2023 Jul 1
Author Correction: Structure of human GABA(B) receptor in an inactive state. Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR Nature 32665714 Nature 2020 Jul
Metabolomics of Lung Microdissections Reveals Region- and Sex-Specific Metabolic Effects of Acute Naphthalene Exposure in Mice. Stevens NC, Edwards PC, Tran LM, Ding X, Van Winkle LS, Fiehn O Toxicological sciences : an official journal of the Society of Toxicology 34498071 Toxicol Sci 2021 Nov 24
Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data. Fan S, Kind T, Cajka T, Hazen SL, Tang WHW, Kaddurah-Daouk R, Irvin MR, Arnett DK, Barupal DK, Fiehn O Analytical chemistry 30758187 Anal Chem 2019 Mar 5
In-Silico-Generated Library for Sensitive Detection of 2-Dimethylaminoethylamine Derivatized FAHFA Lipids Using High-Resolution Tandem Mass Spectrometry. Ding J, Kind T, Zhu QF, Wang Y, Yan JW, Fiehn O, Feng YQ Analytical chemistry 32202765 Anal Chem 2020 Apr 21
Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues. Ismail IT, Fiehn O, Elfert A, Helal M, Salama I, El-Said H Cancers 32092943 Cancers (Basel) 2020 Feb 19
Remodeling Lipids in the Transition from Chronic Liver Disease to Hepatocellular Carcinoma. Ismail IT, Elfert A, Helal M, Salama I, El-Said H, Fiehn O Cancers 33396945 Cancers (Basel) 2020 Dec 30
Distinctive Patterns of Flavonoid Biosynthesis in Roots and Nodules of Datisca glomerata and Medicago spp. Revealed by Metabolomic and Gene Expression Profiles. Gifford I, Battenberg K, Vaniya A, Wilson A, Tian L, Fiehn O, Berry AM Frontiers in plant science 30364174 Front Plant Sci 2018
Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O Journal of the American Society for Mass Spectrometry 29667161 J Am Soc Mass Spectrom 2018 May
Integrating bioinformatics approaches for a comprehensive interpretation of metabolomics datasets. Barupal DK, Fan S, Fiehn O Current opinion in biotechnology 29413745 Curr Opin Biotechnol 2018 Dec
Structure of human GABA(B) receptor in an inactive state. Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR Nature 32581365 Nature 2020 Aug
Utilizing cooled liquid chromatography and chemical derivatization to separate and quantify C3-epimers of 25-hydroxy vitamin D and low abundant 1α,25(OH)(2)D3: Application in a pediatric population. DeFelice BC, Pedersen TL, Shorrosh H, Johnson RK, Seifert JA, Norris JM, Fiehn O The Journal of steroid biochemistry and molecular biology 31715316 J Steroid Biochem Mol Biol 2020 Mar
Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Barupal DK, Fiehn O Environmental health perspectives 31557052 Environ Health Perspect 2019 Sep
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology. Barupal DK, Baillie R, Fan S, Saykin AJ, Meikle PJ, Arnold M, Nho K, Fiehn O, Kaddurah-Daouk R, Alzheimer Disease Metabolomics Consortium Alzheimer's & dementia (Amsterdam, Netherlands) 31517024 Alzheimers Dement (Amst) 2019 Dec
Plasma Metabolite Response to Simple, Refined and Unrefined Carbohydrate-Enriched Diets in Older Adults-Randomized Controlled Crossover Trial. Huang NK, Matthan NR, Matuszek G, Lichtenstein AH Metabolites 35736480 Metabolites 2022 Jun 15
Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology. Murray GC, Bais P, Hatton CL, Tadenev ALD, Hoffmann BR, Stodola TJ, Morelli KH, Pratt SL, Schroeder D, Doty R, Fiehn O, John SWM, Bult CJ, Cox GA, Burgess RW Human molecular genetics 35796562 Hum Mol Genet 2022 Nov 28
Acyl-CoA Identification in Mouse Liver Samples Using the In Silico CoA-Blast Tandem Mass Spectral Library. Keshet U, Kind T, Lu X, Devi S, Fiehn O Analytical chemistry 35119811 Anal Chem 2022 Feb 15
A metabolome atlas of the aging mouse brain. Ding J, Ji J, Rabow Z, Shen T, Folz J, Brydges CR, Fan S, Lu X, Mehta S, Showalter MR, Zhang Y, Araiza R, Bower LR, Lloyd KCK, Fiehn O Nature communications 34654818 Nat Commun 2021 Oct 15
Cellular transformation promotes the incorporation of docosahexaenoic acid into the endolysosome-specific lipid bis(monoacylglycerol)phosphate in breast cancer. Berg AL, Showalter MR, Kosaisawe N, Hu M, Stephens NC, Sa M, Heil H, Castro N, Chen JJ, VanderVorst K, Wheeler MR, Rabow Z, Cajka T, Albeck J, Fiehn O, Carraway KL 3rd Cancer letters 36773796 Cancer Lett 2023 Mar 31
Comparison of Plasma Metabolome Response to Diets Enriched in Soybean and Partially-Hydrogenated Soybean Oil in Moderately Hypercholesterolemic Adults-A Pilot Study. Huang NK, Lichtenstein AH, Matuszek G, Matthan NR Metabolites 37110133 Metabolites 2023 Mar 26
Predicting Collision-Induced-Dissociation Tandem Mass Spectra (CID-MS/MS) Using Ab Initio Molecular Dynamics. Lee J, Tantillo DJ, Wang LP, Fiehn O Journal of chemical information and modeling 39329407 J Chem Inf Model 2024 Oct 14
Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse. Giacalone AG, Merritt ME, Ragavan M Journal of visualized experiments : JoVE 35343950 J Vis Exp 2022 Mar 9
Measuring NQO1 Bioactivation Using [(2)H(7)]Glucose. Mahar R, Chang MC, Merritt ME Cancers 34439319 Cancers (Basel) 2021 Aug 19
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD. Muyyarikkandy MS, McLeod M, Maguire M, Mahar R, Kattapuram N, Zhang C, Surugihalli C, Muralidaran V, Vavilikolanu K, Mathews CE, Merritt ME, Sunny NE FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32918763 FASEB J 2020 Nov
Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep. Ragavan M, Li M, Giacalone AG, Wood CE, Keller-Wood M, Merritt ME Metabolites 33466367 Metabolites 2021 Jan 5
Enrichment of hepatic glycogen and plasma glucose from H₂(18) O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice. Coelho M, Mahar R, Belew GD, Torres A, Barosa C, Cabral F, Viegas I, Gastaldelli A, Mendes VM, Manadas B, Jones JG, Merritt ME NMR in biomedicine 36151589 NMR Biomed 2023 Feb
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis. Takata N, Miska JM, Morgan MA, Patel P, Billingham LK, Joshi N, Schipma MJ, Dumar ZJ, Joshi NR, Misharin AV, Embry RB, Fiore L, Gao P, Diebold LP, McElroy GS, Shilatifard A, Chandel NS, Oliver G Nature communications 37452018 Nat Commun 2023 Jul 14
Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension. Philip N, Yun X, Pi H, Murray S, Hill Z, Fonticella J, Perez P, Zhang C, Pathmasiri W, Sumner S, Servinsky L, Jiang H, Huetsch JC, Oldham WM, Visovatti S, Leary PJ, Gharib SA, Brittain E, Simpson CE, Le A, Shimoda LA, Suresh K American journal of physiology. Lung cellular and molecular physiology 38226418 Am J Physiol Lung Cell Mol Physiol 2024 Mar 1
Mitochondrial complex I promotes kidney cancer metastasis. Bezwada D, Perelli L, Lesner NP, Cai L, Brooks B, Wu Z, Vu HS, Sondhi V, Cassidy DL, Kasitinon S, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, McDaniel P, Sudderth J, Dumesnil D, House S, Rosales T, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Garcia-Bermudez J, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Genovese G, Margulis V, DeBerardinis RJ Nature 39143213 Nature 2024 Sep
Editorial for "Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1-(13) C]pyruvate MRI". Merritt ME Journal of magnetic resonance imaging : JMRI 35416358 J Magn Reson Imaging 2022 Dec
Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State. Ragavan M, McLeod MA, Giacalone AG, Merritt ME Metabolites 34357335 Metabolites 2021 Jul 5
Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors. Karagiannis D, Wu W, Li A, Hayashi M, Chen X, Yip M, Mangipudy V, Xu X, Sánchez-Rivera FJ, Soto-Feliciano YM, Ye J, Papagiannakopoulos T, Lu C Cell reports 38165806 Cell Rep 2024 Jan 23
Matrix Linear Models for connecting metabolite composition to individual characteristics. Farage G, Zhao C, Choi HY, Garrett TJ, Kechris K, Elam MB, Sen Ś bioRxiv : the preprint server for biology 38187579 bioRxiv 2023 Dec 20
Lipidomic Analysis Reveals Differences in the Extent of Remyelination in the Brain and Spinal Cord. De Silva Mohotti N, Kobayashi H, Williams JM, Binjawadagi R, Evertsen MP, Christ EG, Hartley MD Journal of proteome research 38018851 J Proteome Res 2024 Aug 2
Targeted Bmal1 restoration in muscle prolongs lifespan with systemic health effects in aging model. Gutierrez-Monreal MA, Wolff CA, Rijos EE, Viggars MR, Douglas CM, Pagala V, Peng J, Hunt LC, Ding H, Huo Z, Demontis F, Esser KA JCI insight 39352748 JCI Insight 2024 Oct 1
Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-(13)C] Pyruvate. Ragavan M, McLeod MA, Rushin A, Merritt ME Frontiers in physiology 35197867 Front Physiol 2022
Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy. Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, Wojtkowiak JW, Swietach P, Gatenby RA, Bui MM, Merritt ME, McDonald P, Garrett TJ, Gillies RJ Cell reports 35545051 Cell Rep 2022 May 10
Murine Norovirus Interaction with Enterobacter cloacae Leads to Changes in Membrane Stability and Packaging of Lipid and Metabolite Vesicle Content. Mosby CA, Edelmann MJ, Jones MK Microbiology spectrum 36943087 Microbiol Spectr 2023 Mar 21
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer. Chang MC, Mahar R, McLeod MA, Giacalone AG, Huang X, Boothman DA, Merritt ME Nutrients 35893874 Nutrients 2022 Jul 22
Metabolic abnormalities in the bone marrow cells of young offspring born to obese mothers. Alina M, Phillips E, Alharithi Y, Kadam L, Coussens L, Kumar S Research square 38313293 Res Sq 2024 Jan 16
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples. Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang MC, Pachnis P, Yang C, Kelekar S, Gu W, Brooks B, Ko B, Vu HS, Mathews TP, Zacharias LG, Martin-Sandoval M, Do D, Oaxaca KC, Jin ES, Margulis V, Malloy CR, Merritt ME, DeBerardinis RJ Cell metabolism 37611583 Cell Metab 2023 Oct 3
Deuterated water imaging of the rat brain following metabolism of [(2) H(7) ]glucose. Mahar R, Zeng H, Giacalone A, Ragavan M, Mareci TH, Merritt ME Magnetic resonance in medicine 33576535 Magn Reson Med 2021 Jun
Metabolic signatures associated with oncolytic myxoma viral infections. Mahar R, Ragavan M, Chang MC, Hardiman S, Moussatche N, Behar A, Renne R, Merritt ME Scientific reports 35871072 Sci Rep 2022 Jul 23
INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis. Rahim M, Ragavan M, Deja S, Merritt ME, Burgess SC, Young JD Metabolic engineering 34965470 Metab Eng 2022 Jan
Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls. Myer C, Perez J, Abdelrahman L, Mendez R, Khattri RB, Junk AK, Bhattacharya SK Experimental eye research 32246983 Exp Eye Res 2020 May
Metabogenomics reveals four candidate regions involved in the pathophysiology of Equine Metabolic Syndrome. Patterson Rosa L, Mallicote MF, Long MT, Brooks SA Molecular and cellular probes 32659253 Mol Cell Probes 2020 Oct
The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A(2) coordinates acute wound healing and repair. MacKnight HP, Stephenson DJ, Hoeferlin LA, Benusa SD, DeLigio JT, Maus KD, Ali AN, Wayne JS, Park MA, Hinchcliffe EH, Brown RE, Ryan JJ, Diegelmann RF, Chalfant CE Science signaling 31796632 Sci Signal 2019 Dec 3
Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells. Rohani L, Borys BS, Razian G, Naghsh P, Liu S, Johnson AA, Machiraju P, Holland H, Lewis IA, Groves RA, Toms D, Gordon PMK, Li JW, So T, Dang T, Kallos MS, Rancourt DE Communications biology 32895477 Commun Biol 2020 Sep 7
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, Niangaly M, Cisse H, Doumtabe D, Skinner J, Sturdevant D, Ricklefs S, Virtaneva K, Asghar M, Homann MV, Turner L, Martins J, Allman EL, N'Dri ME, Winkler V, Llinás M, Lavazec C, Martens C, Färnert A, Kayentao K, Ongoiba A, Lavstsen T, Osório NS, Otto TD, Recker M, Traore B, Crompton PD, Portugal S Nature medicine 33106664 Nat Med 2020 Dec
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR Nature communications 33767183 Nat Commun 2021 Mar 25
Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramírez-Palacios P, Salmerón J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ Lipids in health and disease 34629052 Lipids Health Dis 2021 Oct 10
Utilizing Untargeted Ion Mobility-Mass Spectrometry To Profile Changes in the Gut Metabolome Following Biliary Diversion Surgery. Poland JC, Schrimpe-Rutledge AC, Sherrod SD, Flynn CR, McLean JA Analytical chemistry 31573190 Anal Chem 2019 Nov 19
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Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium. Nemutlu E, Gupta A, Zhang S, Viqar M, Holmuhamedov E, Terzic A, Jahangir A, Dzeja P PloS one 26378442 PLoS One 2015
Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E EBioMedicine 26086035 EBioMedicine 2015 Apr 1
Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial. Dassau E, Brown SA, Basu A, Pinsker JE, Kudva YC, Gondhalekar R, Patek S, Lv D, Schiavon M, Lee JB, Dalla Man C, Hinshaw L, Castorino K, Mallad A, Dadlani V, McCrady-Spitzer SK, McElwee-Malloy M, Wakeman CA, Bevier WC, Bradley PK, Kovatchev B, Cobelli C, Zisser HC, Doyle FJ 3rd The Journal of clinical endocrinology and metabolism 26204135 J Clin Endocrinol Metab 2015 Oct
Glucocorticoid Excess Increases Hepatic 11β-HSD-1 Activity in Humans: Implications in Steroid-Induced Diabetes. Dube S, Slama MQ, Basu A, Rizza RA, Basu R The Journal of clinical endocrinology and metabolism 26308294 J Clin Endocrinol Metab 2015 Nov
Elevated baseline serum glutamate as a pharmacometabolomic biomarker for acamprosate treatment outcome in alcohol-dependent subjects. Nam HW, Karpyak VM, Hinton DJ, Geske JR, Ho AM, Prieto ML, Biernacka JM, Frye MA, Weinshilboum RM, Choi DS Translational psychiatry 26285131 Transl Psychiatry 2015 Aug 18
Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans. Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR The Journal of clinical endocrinology and metabolism 26709968 J Clin Endocrinol Metab 2016 Feb
Direct Evidence of Acetaminophen Interference with Subcutaneous Glucose Sensing in Humans: A Pilot Study. Basu A, Veettil S, Dyer R, Peyser T, Basu R Diabetes technology & therapeutics 26784129 Diabetes Technol Ther 2016 Feb
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients. Shang P, Ho AM, Tufvesson-Alm M, Lindberg DR, Grant CW, Orhan F, Eren F, Bhat M, Engberg G, Schwieler L, Fatouros-Bergman H, Imbeault S, Iverson RM, Dasari S, Piehl F, Cervenka S, Sellgren CM, Erhardt S, Choi DS Translational psychiatry 35665740 Transl Psychiatry 2022 Jun 3
Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. Kakazu E, Mauer AS, Yin M, Malhi H Journal of lipid research 26621917 J Lipid Res 2016 Feb
Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach. Mallad A, Hinshaw L, Schiavon M, Dalla Man C, Dadlani V, Basu R, Lingineni R, Cobelli C, Johnson ML, Carter R, Kudva YC, Basu A American journal of physiology. Endocrinology and metabolism 25898950 Am J Physiol Endocrinol Metab 2015 Jun 15
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR The Journal of clinical investigation 27525440 J Clin Invest 2016 Sep 1
Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice. Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G Cellular and molecular gastroenterology and hepatology 27795979 Cell Mol Gastroenterol Hepatol 2016 Jul
MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB. Shintaku J, Peterson JM, Talbert EE, Gu JM, Ladner KJ, Williams DR, Mousavi K, Wang R, Sartorelli V, Guttridge DC Cell reports 27705798 Cell Rep 2016 Oct 4
Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR Aging 28379838 Aging (Albany NY) 2017 Apr
Untargeted metabolomics in primary murine bone marrow stromal cells reveals distinct profile throughout osteoblast differentiation. Misra BB, Jayapalan S, Richards AK, Helderman RCM, Rendina-Ruedy E Metabolomics : Official journal of the Metabolomic Society 34537901 Metabolomics 2021 Sep 18
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk. Forteza MJ, Berg M, Edsfeldt A, Sun J, Baumgartner R, Kareinen I, Casagrande FB, Hedin U, Zhang S, Vuckovic I, Dzeja PP, Polyzos KA, Gisterå A, Trauelsen M, Schwartz TW, Dib L, Herrmann J, Monaco C, Matic L, Gonçalves I, Ketelhuth DFJ Cardiovascular research 36866436 Cardiovasc Res 2023 Jul 4
Identification of circulating plasma ceramides as a potential sexually dimorphic biomarker of pancreatic cancer-induced cachexia. Chakedis JM, Dillhoff ME, Schmidt CR, Rajasekera PV, Evans DC, Williams TM, Guttridge DC, Talbert EE JCSM rapid communications 36591536 JCSM Rapid Commun 2022 Jul-Dec
Insulin Regulation of Lysine and α-Aminoadipic Acid Dynamics and Amino Metabolites in Women With and Without Insulin Resistance. Chang AY, Asokan AK, Lalia AZ, Sakrikar D, Lanza IR, Petterson XM, Nair KS Diabetes 38968429 Diabetes 2024 Oct 1
Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools. Sud M, Fahy E, Cotter D, Azam K, Vadivelu I, Burant C, Edison A, Fiehn O, Higashi R, Nair KS, Sumner S, Subramaniam S Nucleic acids research 26467476 Nucleic Acids Res 2016 Jan 4
Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM). Lane AN, Higashi RM, Fan TW Metabolomics : Official journal of the Metabolomic Society 27489532 Metabolomics 2016 Jul
Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study. Fan TW, Warmoes MO, Sun Q, Song H, Turchan-Cholewo J, Martin JT, Mahan A, Higashi RM, Lane AN Cold Spring Harbor molecular case studies 27551682 Cold Spring Harb Mol Case Stud 2016 Jul
Aberrant coordination geometries discovered in the most abundant metalloproteins. Yao S, Flight RM, Rouchka EC, Moseley HN Proteins 28142195 Proteins 2017 May
Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Zaytseva YY, Rychahou PG, Le AT, Scott TL, Flight RM, Kim JT, Harris J, Liu J, Wang C, Morris AJ, Sivakumaran TA, Fan T, Moseley H, Gao T, Lee EY, Weiss HL, Heuer TS, Kemble G, Evers M Oncotarget 29872506 Oncotarget 2018 May 15
Applications of Chromatography-Ultra High-Resolution MS for Stable Isotope-Resolved Metabolomics (SIRM) Reconstruction of Metabolic Networks. Sun Q, Fan TW, Lane AN, Higashi RM Trends in analytical chemistry : TRAC 32483395 Trends Analyt Chem 2020 Feb
Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective. Fan TW, Higashi RM, Chernayavskaya Y, Lane AN Metabolites 32549391 Metabolites 2020 Jun 15
Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction. Wang T, Gnanaprakasam JNR, Chen X, Kang S, Xu X, Sun H, Liu L, Rodgers H, Miller E, Cassel TA, Sun Q, Vicente-Muñoz S, Warmoes MO, Lin P, Piedra-Quintero ZL, Guerau-de-Arellano M, Cassady KA, Zheng SG, Yang J, Lane AN, Song X, Fan TW, Wang R Nature metabolism 32694789 Nat Metab 2020 Jul
6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function. Daneshmandi S, Cassel T, Higashi RM, Fan TW, Seth P eLife 34709178 Elife 2021 Oct 28
Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance. Lane AN, Arumugam S, Lorkiewicz PK, Higashi RM, Laulhé S, Nantz MH, Moseley HN, Fan TW Magnetic resonance in chemistry : MRC 25616249 Magn Reson Chem 2015 May
SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery. Saxena N, Maio N, Crooks DR, Ricketts CJ, Yang Y, Wei MH, Fan TW, Lane AN, Sourbier C, Singh A, Killian JK, Meltzer PS, Vocke CD, Rouault TA, Linehan WM Journal of the National Cancer Institute 26719882 J Natl Cancer Inst 2016 Jan
An obligatory role for neurotensin in high-fat-diet-induced obesity. Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM Nature 27193687 Nature 2016 May 19
Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS. Deng P, Higashi RM, Lane AN, Bruntz RC, Sun RC, Ramakrishnam Raju MV, Nantz MH, Qi Z, Fan TW The Analyst 29192912 Analyst 2017 Dec 18
Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471. Cui Z, Wang X, Koppermann S, Thorson JS, Ducho C, Van Lanen SG Journal of natural products 29553733 J Nat Prod 2018 Apr 27
Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M 2nd, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P Cell metabolism 24726384 Cell Metab 2014 May 6
Regulation of hepatic glutamine metabolism by miR-122. Sengupta D, Cassel T, Teng KY, Aljuhani M, Chowdhary VK, Hu P, Zhang X, Fan TW, Ghoshal K Molecular metabolism 32180557 Mol Metab 2020 Apr
Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer. Bruntz RC, Belshoff AC, Zhang Y, Macedo JKA, Higashi RM, Lane AN, Fan TW Proteomics 31298457 Proteomics 2019 Nov
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues. Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN The Journal of biological chemistry 31337706 J Biol Chem 2019 Sep 6
NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics. Lin P, Dai L, Crooks DR, Neckers LM, Higashi RM, Fan TW, Lane AN Metabolites 33805301 Metabolites 2021 Mar 29
NMR and MS-based Stable Isotope-Resolved Metabolomics and Applications in Cancer Metabolism. Lane AN, Higashi RM, Fan TW Trends in analytical chemistry : TRAC 32523238 Trends Analyt Chem 2019 Nov
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. Sellers K, Fox MP, Bousamra M 2nd, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, Lane AN, Fan TW The Journal of clinical investigation 25607840 J Clin Invest 2015 Feb
Ketogenesis contributes to intestinal cell differentiation. Wang Q, Zhou Y, Rychahou P, Fan TW, Lane AN, Weiss HL, Evers BM Cell death and differentiation 27935584 Cell Death Differ 2017 Mar
Exercise-induced changes in myocardial glucose utilization during periods of active cardiac growth. Fulghum KL, Collins HE, Lorkiewicz PK, Cassel TA, Fan TWM, Hill BG Journal of molecular and cellular cardiology 38703412 J Mol Cell Cardiol 2024 Jun
Regulation of mammalian nucleotide metabolism and biosynthesis. Lane AN, Fan TW Nucleic acids research 25628363 Nucleic Acids Res 2015 Feb 27
Inference of cancer mechanisms through computational systems analysis. Qi Z, Voit EO Molecular bioSystems 28112324 Mol Biosyst 2017 Feb 28
Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics. Lane AN, Tan J, Wang Y, Yan J, Higashi RM, Fan TW Metabolic engineering 28163219 Metab Eng 2017 Sep
Perspectives and expectations in structural bioinformatics of metalloproteins. Yao S, Flight RM, Rouchka EC, Moseley HN Proteins 28168746 Proteins 2017 May
Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. Matrka MC, Watanabe M, Muraleedharan R, Lambert PF, Lane AN, Romick-Rosendale LE, Wells SI PloS one 28558019 PLoS One 2017
The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer. Wen YA, Xiong X, Scott T, Li AT, Wang C, Weiss HL, Tan L, Bradford E, Fan TWM, Chandel NS, Barrett TA, Gao T Cell death and differentiation 30659235 Cell Death Differ 2019 Oct
Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes. Sellers K, Allen TD, Bousamra M 2nd, Tan J, Méndez-Lucas A, Lin W, Bah N, Chernyavskaya Y, MacRae JI, Higashi RM, Lane AN, Fan TW, Yuneva MO British journal of cancer 31114017 Br J Cancer 2019 Jul
Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees. Zhang Y, Zhang X, Lane AN, Fan TW, Liu J IEEE journal of biomedical and health informatics 31380773 IEEE J Biomed Health Inform 2020 May
A Micro-Scale Analytical Method for Determining Glycogen Turnover by NMR and FTMS. Scott TL, Zhu J, Cassel TA, Vicente-Muñoz S, Lin P, Higashi RM, Lane AN, Fan TW Metabolites 36005633 Metabolites 2022 Aug 18
Untargeted Lipidomics of Non-Small Cell Lung Carcinoma Demonstrates Differentially Abundant Lipid Classes in Cancer vs. Non-Cancer Tissue. Mitchell JM, Flight RM, Moseley HNB Metabolites 34822397 Metabolites 2021 Oct 28
Improved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry. Kang WY, Thompson PT, El-Amouri SS, Fan TWM, Lane AN, Higashi RM Analytica chimica acta 31409459 Anal Chim Acta 2019 Nov 8
In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium. Fulghum KL, Audam TN, Lorkiewicz PK, Zheng Y, Merchant M, Cummins TD, Dean WL, Cassel TA, Fan TWM, Hill BG Journal of molecular and cellular cardiology 34487754 J Mol Cell Cardiol 2022 Jan
Multifocal Renal Cell Carcinomas With Somatic IDH2 Mutation: Report of a Previously Undescribed Neoplasm. Merino MJ, Ricketts CJ, Moreno V, Yang Y, Fan TWM, Lane AN, Meltzer PS, Vocke CD, Crooks DR, Linehan WM The American journal of surgical pathology 33165095 Am J Surg Pathol 2021 Jan
Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway. Panarsky R, Crooks DR, Lane AN, Yang Y, Cassel TA, Fan TW, Linehan WM, Moscow JA Cancer & metabolism 32774853 Cancer Metab 2020
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues. Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN Journal of immunology (Baltimore, Md. : 1950) 36150727 J Immunol 2022 Nov 1
Stable isotope-resolved metabolomics analyses of metabolic phenotypes reveal variable glutamine metabolism in different patient-derived models of non-small cell lung cancer from a single patient. Kinslow CJ, Ll MB, Cai Y, Yan J, Lorkiewicz PK, Al-Attar A, Tan J, Higashi RM, Lane AN, Fan TW Metabolomics : Official journal of the Metabolomic Society 39068202 Metabolomics 2024 Jul 27
Applications of NMR spectroscopy to systems biochemistry. Fan TW, Lane AN Progress in nuclear magnetic resonance spectroscopy 26952191 Prog Nucl Magn Reson Spectrosc 2016 Feb
Stable Isotope Resolved Metabolomics Studies in Ex Vivo TIssue Slices. Fan TW, Lane AN, Higashi RM Bio-protocol 27158639 Bio Protoc 2016 Feb 5
Mitochondrial superoxide targets energy metabolism to modulate epigenetic regulation of NRF2-mediated transcription. Dhar SK, Scott T, Wang C, Fan TWM, St Clair DK Free radical biology & medicine 34968705 Free Radic Biol Med 2022 Feb 1
Rapid analysis of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) isotopologues in stable isotope-resolved metabolomics (SIRM) using direct infusion nanoelectrospray ultra-high-resolution Fourier transform mass spectrometry (DI-nESI-UHR-FTMS). Yang J, Fan TWM, Brandon JA, Lane AN, Higashi RM Analytica chimica acta 34556237 Anal Chim Acta 2021 Oct 9
Development and in silico evaluation of large-scale metabolite identification methods using functional group detection for metabolomics. Mitchell JM, Fan TW, Lane AN, Moseley HN Frontiers in genetics 25120557 Front Genet 2014
Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction. Crooks DR, Fan TW, Linehan WM Methods in molecular biology (Clifton, N.J.) 30725447 Methods Mol Biol 2019
UCP2 Overexpression Redirects Glucose into Anabolic Metabolic Pathways. Sreedhar A, Cassell T, Smith P, Lu D, Nam HW, Lane AN, Zhao Y Proteomics 30556651 Proteomics 2019 Feb
Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium. Zhong Y, Mohan K, Liu J, Al-Attar A, Lin P, Flight RM, Sun Q, Warmoes MO, Deshpande RR, Liu H, Jung KS, Mitov MI, Lin N, Butterfield DA, Lu S, Liu J, Moseley HNB, Fan TWM, Kleinman ME, Wang QJ Biochimica et biophysica acta. Molecular basis of disease 32592935 Biochim Biophys Acta Mol Basis Dis 2020 Oct 1
Pyridoxal-5'-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis. Cui Z, Overbay J, Wang X, Liu X, Zhang Y, Bhardwaj M, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG Nature chemical biology 32483377 Nat Chem Biol 2020 Aug
A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver. Wu H, Reizel T, Wang YJ, Lapiro JL, Kren BT, Schug J, Rao S, Morgan A, Herman A, Shekels LL, Rassette MS, Lane AN, Cassel T, Fan TWM, Manivel JC, Gunewardena S, Apte U, Sicinski P, Kaestner KH, Albrecht JH Proceedings of the National Academy of Sciences of the United States of America 32631996 Proc Natl Acad Sci U S A 2020 Jul 21
Exosomal lipids for classifying early and late stage non-small cell lung cancer. Fan TWM, Zhang X, Wang C, Yang Y, Kang WY, Arnold S, Higashi RM, Liu J, Lane AN Analytica chimica acta 30292300 Anal Chim Acta 2018 Dec 11
Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing. Sun RC, Fan TW, Deng P, Higashi RM, Lane AN, Le AT, Scott TL, Sun Q, Warmoes MO, Yang Y Nature communications 29158483 Nat Commun 2017 Nov 21
Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues. Fan TW, Higashi RM, Song H, Daneshmandi S, Mahan AL, Purdom MS, Bocklage TJ, Pittman TA, He D, Wang C, Lane AN eLife 34406120 Elife 2021 Aug 18
An Ion Chromatography-Ultrahigh-Resolution-MS(1)/Data-Independent High-Resolution MS(2) Method for Stable Isotope-Resolved Metabolomics Reconstruction of Central Metabolic Networks. Sun Q, Fan TW, Lane AN, Higashi RM Analytical chemistry 33482055 Anal Chem 2021 Feb 9
Serine synthesis influences tamoxifen response in ER+ human breast carcinoma. Metcalf S, Petri BJ, Kruer T, Green B, Dougherty S, Wittliff JL, Klinge CM, Clem BF Endocrine-related cancer 33112838 Endocr Relat Cancer 2021 Jan
NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry. Lane AN, Fan TW Archives of biochemistry and biophysics 28263717 Arch Biochem Biophys 2017 Aug 15
Two Cooperative Glycosyltransferases Are Responsible for the Sugar Diversity of Saquayamycins Isolated from Streptomyces sp. KY 40-1. Salem SM, Weidenbach S, Rohr J ACS chemical biology 28892347 ACS Chem Biol 2017 Oct 20
Quantification of Isotopologues of Amino Acids by Multiplexed Stable Isotope-Resolved Metabolomics Using Ultrahigh-Resolution Mass Spectrometry Coupled with Direct Infusion. Yang Y, Fan TW, Lane AN, Higashi RM Methods in molecular biology (Clifton, N.J.) 31347110 Methods Mol Biol 2019
Advances in gene ontology utilization improve statistical power of annotation enrichment. Hinderer EW 3rd, Flight RM, Dubey R, MacLeod JN, Moseley HNB PloS one 31415589 PLoS One 2019
Metabolomics enables precision medicine: "A White Paper, Community Perspective". Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R, for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative Metabolomics : Official journal of the Metabolomic Society 27642271 Metabolomics 2016
Mutant IDH1 and thrombosis in gliomas. Unruh D, Schwarze SR, Khoury L, Thomas C, Wu M, Chen L, Chen R, Liu Y, Schwartz MA, Amidei C, Kumthekar P, Benjamin CG, Song K, Dawson C, Rispoli JM, Fatterpekar G, Golfinos JG, Kondziolka D, Karajannis M, Pacione D, Zagzag D, McIntyre T, Snuderl M, Horbinski C Acta neuropathologica 27664011 Acta Neuropathol 2016 Dec
5-Formylcytosine does not change the global structure of DNA. Hardwick JS, Ptchelkine D, El-Sagheer AH, Tear I, Singleton D, Phillips SEV, Lane AN, Brown T Nature structural & molecular biology 28504696 Nat Struct Mol Biol 2017 Jun
Scan-Centric, Frequency-Based Method for Characterizing Peaks from Direct Injection Fourier Transform Mass Spectrometry Experiments. Flight RM, Mitchell JM, Moseley HNB Metabolites 35736448 Metabolites 2022 Jun 2
NMR Analysis of Carboxylate Isotopomers of (13)C-Metabolites by Chemoselective Derivatization with (15)N-Cholamine. Vicente-Muñoz S, Lin P, Fan TW, Lane AN Analytical chemistry 33880916 Anal Chem 2021 May 4
Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function. Daneshmandi S, Cassel T, Lin P, Higashi RM, Wulf GM, Boussiotis VA, Fan TW, Seth P Cell reports 33691103 Cell Rep 2021 Mar 9
New methods to identify high peak density artifacts in Fourier transform mass spectra and to mitigate their effects on high-throughput metabolomic data analysis. Mitchell JM, Flight RM, Wang QJ, Higashi RM, Fan TW, Lane AN, Moseley HNB Metabolomics : Official journal of the Metabolomic Society 30830442 Metabolomics 2018 Sep 17
Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. Liu M, Luo F, Ding C, Albeituni S, Hu X, Ma Y, Cai Y, McNally L, Sanders MA, Jain D, Kloecker G, Bousamra M 2nd, Zhang HG, Higashi RM, Lane AN, Fan TW, Yan J Journal of immunology (Baltimore, Md. : 1950) 26453753 J Immunol 2015 Nov 15
A Computational Framework for High-Throughput Isotopic Natural Abundance Correction of Omics-Level Ultra-High Resolution FT-MS Datasets. Carreer WJ, Flight RM, Moseley HN Metabolites 24404440 Metabolites 2013 Sep 25
Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition. Tarrado-Castellarnau M, Cortés R, Zanuy M, Tarragó-Celada J, Polat IH, Hill R, Fan TW, Link W, Cascante M Pharmacological research 26375988 Pharmacol Res 2015 Dec
(13)C Tracer Studies of Metabolism in Mouse Tumor Xenografts. Lane AN, Yan J, Fan TW Bio-protocol 26693168 Bio Protoc 2015 Nov 20
Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM). Yang Y, Fan TW, Lane AN, Higashi RM Analytica chimica acta 28576319 Anal Chim Acta 2017 Jul 11
Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells. Crooks DR, Maio N, Lane AN, Jarnik M, Higashi RM, Haller RG, Yang Y, Fan TW, Linehan WM, Rouault TA The Journal of biological chemistry 29523684 J Biol Chem 2018 May 25
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R eLife 30198844 Elife 2018 Sep 10
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells. Zhao J, Li J, Fan TWM, Hou SX Oncotarget 29137367 Oncotarget 2017 Oct 13
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, Rice CM, Rouault TA, Cassel T, Higashi RM, Lane AN, Fan TW, Wink DA, McVicar DW Nature communications 32019928 Nat Commun 2020 Feb 4
GOcats: A tool for categorizing Gene Ontology into subgraphs of user-defined concepts. Hinderer EW 3rd, Moseley HNB PloS one 32525872 PLoS One 2020
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells. Ulmer CZ, Yost RA, Chen J, Mathews CE, Garrett TJ Journal of proteomics & bioinformatics 26401069 J Proteomics Bioinform 2015 Jun
Superior Glucose Tolerance and Metabolomic Profiles, Independent of Adiposity, in HIV-Infected Women Compared With Men on Antiretroviral Therapy. Koethe JR, Jenkins CA, Petucci C, Culver J, Shepherd BE, Sterling TR Medicine 27175676 Medicine (Baltimore) 2016 May
Skeletal muscle fiber analysis by atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometric imaging at high mass and high spatial resolution. Tsai YH, Bhandari DR, Garrett TJ, Carter CS, Spengler B, Yost RA Proteomics 27198224 Proteomics 2016 Jun
Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods. Bingol K, Brüschweiler R Current opinion in biotechnology 27552705 Curr Opin Biotechnol 2017 Feb
NMR-based metabolomics reveals urinary metabolome modifications in female Sprague-Dawley rats by cranberry procyanidins. Liu H, Tayyari F, Edison AS, Su Z, Gu L The Journal of nutritional biochemistry 27309592 J Nutr Biochem 2016 Aug
Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients. Weng L, Quinlivan E, Gong Y, Beitelshees AL, Shahin MH, Turner ST, Chapman AB, Gums JG, Johnson JA, Frye RF, Garrett TJ, Cooper-DeHoff RM Metabolic syndrome and related disorders 25664967 Metab Syndr Relat Disord 2015 Jun
Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison AS, Ito T Nature 28514443 Nature 2017 May 25
Global Metabolomics in Allogeneic Hematopoietic Cell Transplantation Recipients Discordant for Chronic Graft-versus-Host Disease. Lynch Kelly D, Farhadfar N, Starkweather A, Garrett TJ, Yao Y, Wingard JR, Mahmud I, Menzies V, Patel P, Alabasi KM, Lyon D Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 32592859 Biol Blood Marrow Transplant 2020 Oct
Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients. Lanfear DE, Gibbs JJ, Li J, She R, Petucci C, Culver JA, Tang WHW, Pinto YM, Williams LK, Sabbah HN, Gardell SJ JACC. Heart failure 29096792 JACC Heart Fail 2017 Nov
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Elevated ozone reduces photosynthetic carbon gain by accelerating leaf senescence of inbred and hybrid maize in a genotype-specific manner. Yendrek CR, Erice G, Montes CM, Tomaz T, Sorgini CA, Brown PJ, McIntyre LM, Leakey ADB, Ainsworth EA Plant, cell & environment 29044553 Plant Cell Environ 2017 Dec
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Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives. Chouinard CD, Wei MS, Beekman CR, Kemperman RH, Yost RA Clinical chemistry 26585928 Clin Chem 2016 Jan
Proteometabolomics of Melphalan Resistance in Multiple Myeloma. Koomen DC, Guingab-Cagmat JD, Oliveira PS, Fang B, Liu M, Welsh EA, Meads MB, Nguyen T, Meke L, Eschrich SA, Shain KH, Garrett TJ, Koomen JM Methods in molecular biology (Clifton, N.J.) 31127562 Methods Mol Biol 2019
Customized metabolomics database for the analysis of NMR ¹H-¹H TOCSY and ¹³C-¹H HSQC-TOCSY spectra of complex mixtures. Bingol K, Bruschweiler-Li L, Li DW, Brüschweiler R Analytical chemistry 24773139 Anal Chem 2014 Jun 3
SECIMTools: a suite of metabolomics data analysis tools. Kirpich AS, Ibarra M, Moskalenko O, Fear JM, Gerken J, Mi X, Ashrafi A, Morse AM, McIntyre LM BMC bioinformatics 29678131 BMC Bioinformatics 2018 Apr 20
In vivo hyperpolarization transfer in a clinical MRI scanner. von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME Magnetic resonance in medicine 29488244 Magn Reson Med 2018 Aug
Portable FAIMS: Applications and Future Perspectives. Costanzo MT, Boock JJ, Kemperman RHJ, Wei MS, Beekman CR, Yost RA International journal of mass spectrometry 29335669 Int J Mass Spectrom 2017 Nov
l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells. Gill EL, Raman S, Yost RA, Garrett TJ, Vedam-Mai V ACS chemical neuroscience 29370524 ACS Chem Neurosci 2018 May 16
Use of principle component analysis to quantitatively score the equine metabolic syndrome phenotype in an Arabian horse population. Lewis SL, Holl HM, Long MT, Mallicote MF, Brooks SA PloS one 30001422 PLoS One 2018
Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology. von Morze C, Merritt ME NMR in biomedicine 29870085 NMR Biomed 2019 Oct
Considerations when choosing a genetic model organism for metabolomics studies. Reed LK, Baer CF, Edison AS Current opinion in chemical biology 28025166 Curr Opin Chem Biol 2017 Feb
Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris. DeRatt BN, Ralat MA, Lysne V, Tayyari F, Dhar I, Edison AS, Garrett TJ, Midttun Ø, Ueland PM, Nygård OK, Gregory JF 3rd The Journal of nutrition 28794210 J Nutr 2017 Sep
Comparison of global metabolite extraction strategies for soybeans using UHPLC-HRMS. Mahmud I, Sternberg S, Williams M, Garrett TJ Analytical and bioanalytical chemistry 28844081 Anal Bioanal Chem 2017 Oct
UHPLC-Q-Orbitrap-HRMS-based global metabolomics reveal metabolome modifications in plasma of young women after cranberry juice consumption. Liu H, Garrett TJ, Su Z, Khoo C, Gu L The Journal of nutritional biochemistry 28433923 J Nutr Biochem 2017 Jul
Intergenerational environmental effects: functional signals in offspring transcriptomes and metabolomes after parental jasmonic acid treatment in apomictic dandelion. Verhoeven KJF, Verbon EH, van Gurp TP, Oplaat C, Ferreira de Carvalho J, Morse AM, Stahl M, Macel M, McIntyre LM The New phytologist 29034954 New Phytol 2018 Jan
LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data. Koelmel JP, Kroeger NM, Ulmer CZ, Bowden JA, Patterson RE, Cochran JA, Beecher CWW, Garrett TJ, Yost RA BMC bioinformatics 28693421 BMC Bioinformatics 2017 Jul 10
The effect of Ho(3+) doping on (13)C dynamic nuclear polarization at 5 T. Sirusi AA, Suh EH, Kovacs Z, Merritt ME Physical chemistry chemical physics : PCCP 29242884 Phys Chem Chem Phys 2018 Jan 3
Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy. Fernandez MR, Schaub FX, Yang C, Li W, Yun S, Schaub SK, Dorsey FC, Liu M, Steeves MA, Ballabio A, Tzankov A, Chen Z, Koomen JM, Berglund AE, Cleveland JL Cancer research 35149590 Cancer Res 2022 Apr 1
Loss of Stearoyl-CoA desaturase 1 leads to cardiac dysfunction and lipotoxicity. Tuthill Ii BF, Quaglia CJ, O'Hara E, Musselman LP The Journal of experimental biology 34423827 J Exp Biol 2021 Sep 15
Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery. Lee B, Mahmud I, Marchica J, Dereziński P, Qi F, Wang F, Joshi P, Valerio F, Rivera I, Patel V, Pavlovich CP, Garrett TJ, Schroth GP, Sun Y, Perera RJ Scientific reports 32111915 Sci Rep 2020 Feb 28
Design and Implementation of a Dual-Probe Microsampling Apparatus for the Direct Analysis of Adherent Mammalian Cells by Ion Mobility-Mass Spectrometry. Domenick TM, Vedam-Mai V, Yost RA Analytical chemistry 32786468 Anal Chem 2020 Sep 1
Longitudinal Changes of One-Carbon Metabolites and Amino Acid Concentrations during Pregnancy in the Women First Maternal Nutrition Trial. Gilley SP, Weaver NE, Sticca EL, Jambal P, Palacios A, Kerns ME, Anand P, Kemp JF, Westcott JE, Figueroa L, Garcés AL, Ali SA, Pasha O, Saleem S, Hambidge KM, Hendricks AE, Krebs NF, Borengasser SJ Current developments in nutrition 32175519 Curr Dev Nutr 2020 Jan
Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world. Koelmel JP, Napolitano MP, Ulmer CZ, Vasiliou V, Garrett TJ, Yost RA, Prasad MNV, Godri Pollitt KJ, Bowden JA Metabolomics : Official journal of the Metabolomic Society 32307636 Metabolomics 2020 Apr 19
Exogenous Fatty Acids Remodel Staphylococcus aureus Lipid Composition through Fatty Acid Kinase. DeMars Z, Singh VK, Bose JL Journal of bacteriology 32366591 J Bacteriol 2020 Jun 25
The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness. Serrano J, Boyd J, Mason C, Smith KR, Karolyi K, Kondo S, Brown IS, Maurya SK, Meshram NN, Serna V, Gilger J, Branch DA, Gardell SJ, Baskin KK, Ayala JE, Pratley RE, Goodpaster BH, Coen PM, Kyriazis GA Research square 36798161 Res Sq 2023 Feb 9
Segmented Flow Strategies for Integrating Liquid Chromatography-Mass Spectrometry with Nuclear Magnetic Resonance for Lipidomics. Lei J, Mahar R, Chang MC, Collins J, Merritt ME, Garrett TJ, Yost RA Analytical chemistry 36630396 Anal Chem 2023 Jan 11
Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice. Milner JJ, Rebeles J, Dhungana S, Stewart DA, Sumner SC, Meyers MH, Mancuso P, Beck MA Journal of immunology (Baltimore, Md. : 1950) 25862817 J Immunol 2015 May 15
Analysis of human serum and whole blood for mineral content by ICP-MS and ICP-OES: development of a mineralomics method. Harrington JM, Young DJ, Essader AS, Sumner SJ, Levine KE Biological trace element research 24917052 Biol Trace Elem Res 2014 Jul
Development of an analytical method for assessment of silver nanoparticle content in biological matrices by inductively coupled plasma mass spectrometry. Poitras EP, Levine MA, Harrington JM, Essader AS, Fennell TR, Snyder RW, Black SL, Sumner SS, Levine KE Biological trace element research 25308764 Biol Trace Elem Res 2015 Feb
Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets. Li YY, Douillet C, Huang M, Beck R, Sumner SJ, Styblo M Archives of toxicology 32277266 Arch Toxicol 2020 Jun
Metabolomics to reveal biomarkers and pathways of preterm birth: a systematic review and epidemiologic perspective. Carter RA, Pan K, Harville EW, McRitchie S, Sumner S Metabolomics : Official journal of the Metabolomic Society 31506796 Metabolomics 2019 Sep 10
Intravenous administration of three multiwalled carbon nanotubes to female rats and their effect on urinary biochemical profile. Mortensen NP, Snyder RW, Pathmasiri W, Moreno Caffaro M, Sumner SJ, Fennell TR Journal of applied toxicology : JAT 34569639 J Appl Toxicol 2022 Mar
Fecal metabolomics reveals products of dysregulated proteolysis and altered microbial metabolism in obesity-related osteoarthritis. Rushing BR, McRitchie S, Arbeeva L, Nelson AE, Azcarate-Peril MA, Li YY, Qian Y, Pathmasiri W, Sumner SCJ, Loeser RF Osteoarthritis and cartilage 34718137 Osteoarthritis Cartilage 2022 Jan
Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure. Laine JE, Bailey KA, Olshan AF, Smeester L, Drobná Z, Stýblo M, Douillet C, García-Vargas G, Rubio-Andrade M, Pathmasiri W, McRitchie S, Sumner SJ, Fry RC Environmental science & technology 27997141 Environ Sci Technol 2017 Jan 3
Using Metabolomics to Investigate Biomarkers of Drug Addiction. Ghanbari R, Sumner S Trends in molecular medicine 29397321 Trends Mol Med 2018 Feb
Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences. Stewart DA, Winnike JH, McRitchie SL, Clark RF, Pathmasiri WW, Sumner SJ Journal of proteome research 27447733 J Proteome Res 2016 Sep 2
Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy. Gooding J, Cao L, Whitaker C, Mwiza JM, Fernander M, Ahmed F, Acuff Z, McRitchie S, Sumner S, Ongeri EM BMC nephrology 31023251 BMC Nephrol 2019 Apr 25
Distribution and biomarkers of carbon-14-labeled fullerene C60 ([(14) C(U)]C60 ) in female rats and mice for up to 30 days after intravenous exposure. Sumner SC, Snyder RW, Wingard C, Mortensen NP, Holland NA, Shannahan JH, Dhungana S, Pathmasiri W, Han L, Lewin AH, Fennell TR Journal of applied toxicology : JAT 25727383 J Appl Toxicol 2015 Dec
Impact of a western diet on the ovarian and serum metabolome. Dhungana S, Carlson JE, Pathmasiri W, McRitchie S, Davis M, Sumner S, Appt SE Maturitas 27621251 Maturitas 2016 Oct
The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes. Schulfer AF, Schluter J, Zhang Y, Brown Q, Pathmasiri W, McRitchie S, Sumner S, Li H, Xavier JB, Blaser MJ The ISME journal 30651608 ISME J 2019 May
Metabolomics in the assessment of chemical-induced reproductive and developmental outcomes using non-invasive biological fluids: application to the study of butylbenzyl phthalate. Sumner S, Snyder R, Burgess J, Myers C, Tyl R, Sloan C, Fennell T Journal of applied toxicology : JAT 19731247 J Appl Toxicol 2009 Nov
Introducing the USA Plant, Algae and Microbial Metabolomics Research Coordination Network (PAMM-NET). Sumner LW, Styczynski M, McLean J, Fiehn O, Jander G, Liao J, Sumner S, Britz-McKibbin P, Welti R, Jones AD, Dorrestein PC, Bearden D, Kaddurah-Daouk R Metabolomics : Official journal of the Metabolomic Society 28018159 Metabolomics 2015 Feb
Blood type biochemistry and human disease. Ewald DR, Sumner SC Wiley interdisciplinary reviews. Systems biology and medicine 27599872 Wiley Interdiscip Rev Syst Biol Med 2016 Nov
Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture. Szabo DT, Pathmasiri W, Sumner S, Birnbaum LS Environmental health perspectives 27814246 Environ Health Perspect 2017 Apr
Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue. Sun X, Stewart DA, Sandhu R, Kirk EL, Pathmasiri WW, McRitchie SL, Clark RF, Troester MA, Sumner SJ PloS one 29668675 PLoS One 2018
Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function. Sandlers Y, Mercier K, Pathmasiri W, Carlson J, McRitchie S, Sumner S, Vernon HJ PloS one 27015085 PLoS One 2016
The Importance of the Biological Impact of Exposure to the Concept of the Exposome. Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW Environmental health perspectives 27258438 Environ Health Perspect 2016 Oct
Plasma metabolomics analysis in sickle cell disease patients with albuminuria - an exploratory study. Elsherif L, Pathmasiri W, McRitchie S, Archer DR, Ataga KI British journal of haematology 30198565 Br J Haematol 2019 May
A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties. Li YY, Stewart DA, Ye XM, Yin LH, Pathmasiri WW, McRitchie SL, Fennell TR, Cheung HY, Sumner SJ Frontiers in pharmacology 30723413 Front Pharmacol 2018
Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa. Weiss ER, Osawa S, Xiong Y, Dhungana S, Carlson J, McRitchie S, Fennell TR Experimental eye research 30885711 Exp Eye Res 2019 Jul
The need for reflective consideration of an integrative understanding of cardiovascular consequences to PVP formulated C60 exposure. Wingard CJ, Holland NA, Thompson LC, Brown JM, Lewin AH, Sumner SJ, Fennell TR, Vidanapathirana AK Toxicological sciences : an official journal of the Society of Toxicology 25422842 Toxicol Sci 2014 Oct
Metabolomics reveal physiological changes in mayfly larvae (Neocloeon triangulifer) at ecological upper thermal limits. Chou H, Pathmasiri W, Deese-Spruill J, Sumner S, Buchwalter DB Journal of insect physiology 28733240 J Insect Physiol 2017 Aug
Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics. McClenathan BM, Stewart DA, Spooner CE, Pathmasiri WW, Burgess JP, McRitchie SL, Choi YS, Sumner SC Vaccine 28169076 Vaccine 2017 Mar 1
Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures. Yeum D, Gilbert-Diamond D, Doherty B, Coker M, Stewart D, Kirchner D, McRitchie S, Sumner S, Karagas MR, Hoen AG Pediatric research 36627359 Pediatr Res 2023 Jul
C₆₀ exposure augments cardiac ischemia/reperfusion injury and coronary artery contraction in Sprague Dawley rats. Thompson LC, Urankar RN, Holland NA, Vidanapathirana AK, Pitzer JE, Han L, Sumner SJ, Lewin AH, Fennell TR, Lust RM, Brown JM, Wingard CJ Toxicological sciences : an official journal of the Society of Toxicology 24431213 Toxicol Sci 2014 Apr
Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study. Mercier K, McRitchie S, Pathmasiri W, Novokhatny A, Koralkar R, Askenazi D, Brophy PD, Sumner S Pediatric nephrology (Berlin, Germany) 27435284 Pediatr Nephrol 2017 Jan
Maternal Early Pregnancy Serum Metabolomics Profile and Abnormal Vaginal Bleeding as Predictors of Placental Abruption: A Prospective Study. Gelaye B, Sumner SJ, McRitchie S, Carlson JE, Ananth CV, Enquobahrie DA, Qiu C, Sorensen TK, Williams MA PloS one 27300725 PLoS One 2016
Effect of endotoxin and alum adjuvant vaccine on peanut allergy. Johnson-Weaver BT, McRitchie S, Mercier KA, Pathmasiri W, Sumner SJ, Chan C, Germolec D, Kulis M, Burks AW, Staats HF The Journal of allergy and clinical immunology 28927819 J Allergy Clin Immunol 2018 Feb
Human microbiota, blood group antigens, and disease. Ewald DR, Sumner SCJ Wiley interdisciplinary reviews. Systems biology and medicine 29316320 Wiley Interdiscip Rev Syst Biol Med 2018 May
Untargeted Metabolomics: Biochemical Perturbations in Golestan Cohort Study Opium Users Inform Intervention Strategies. Li YY, Ghanbari R, Pathmasiri W, McRitchie S, Poustchi H, Shayanrad A, Roshandel G, Etemadi A, Pollock JD, Malekzadeh R, Sumner SCJ Frontiers in nutrition 33415121 Front Nutr 2020
Metabolomics reveals biomarkers of opioid use disorder. Ghanbari R, Li Y, Pathmasiri W, McRitchie S, Etemadi A, Pollock JD, Poustchi H, Rahimi-Movaghar A, Amin-Esmaeili M, Roshandel G, Shayanrad A, Abaei B, Malekzadeh R, Sumner SCJ Translational psychiatry 33542199 Transl Psychiatry 2021 Feb 4
Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients. Brier ME, Gooding JR, Harrington JM, Burgess JP, McRitchie SL, Zhang X, Rovin BH, Klein JB, Himmelfarb J, Sumner SJ, Merchant ML Scientific reports 33214633 Sci Rep 2020 Nov 19
Metabolic profiling of a chronic kidney disease cohort reveals metabolic phenotype more likely to benefit from a probiotic. Saggi SJ, Mercier K, Gooding JR, Friedman E, Vyas U, Ranganathan N, Ranganathan P, McRitchie S, Sumner S International journal of probiotics & prebiotics 30774576 Int J Probiotics Prebiotics 2017
LC-MS-based metabolomics analysis to identify meprin-β-associated changes in kidney tissue from mice with STZ-induced type 1 diabetes and diabetic kidney injury. Gooding J, Cao L, Ahmed F, Mwiza JM, Fernander M, Whitaker C, Acuff Z, McRitchie S, Sumner S, Ongeri EM American journal of physiology. Renal physiology 31411076 Am J Physiol Renal Physiol 2019 Oct 1
Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers. Laue HE, Bauer JA, Pathmasiri W, Sumner SCJ, McRitchie S, Palys TJ, Hoen AG, Madan JC, Karagas MR Pediatric research 38509226 Pediatr Res 2024 Jul
Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Metabolomics. Gooding JR, Agrawal S, McRitchie S, Acuff Z, Merchant ML, Klein JB, Smoyer WE, Sumner SJ, Midwest Pediatric Nephrology Consortium Kidney international reports 31922063 Kidney Int Rep 2020 Jan
Prospective association of the infant gut microbiome with social behaviors in the ECHO consortium. Laue HE, Bonham KS, Coker MO, Moroishi Y, Pathmasiri W, McRitchie S, Sumner S, Hoen AG, Karagas MR, Klepac-Ceraj V, Madan JC, program collaborators for Environmental influences on Child Health Outcomes Molecular autism 38760865 Mol Autism 2024 May 17
Distribution and biomarker of carbon-14 labeled fullerene C60 ([(14) C(U)]C60 ) in pregnant and lactating rats and their offspring after maternal intravenous exposure. Snyder RW, Fennell TR, Wingard CJ, Mortensen NP, Holland NA, Shannahan JH, Pathmasiri W, Lewin AH, Sumner SC Journal of applied toxicology : JAT 26081520 J Appl Toxicol 2015 Dec
PVP formulated fullerene (C60) increases Rho-kinase dependent vascular tissue contractility in pregnant Sprague Dawley rats. Vidanapathirana AK, Thompson LC, Mann EE, Odom JT, Holland NA, Sumner SJ, Han L, Lewin AH, Fennell TR, Brown JM, Wingard CJ Reproductive toxicology (Elmsford, N.Y.) 25088243 Reprod Toxicol 2014 Nov
Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25466902 FASEB J 2015 Mar
A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis. Church RJ, Wu H, Mosedale M, Sumner SJ, Pathmasiri W, Kurtz CL, Pletcher MT, Eaddy JS, Pandher K, Singer M, Batheja A, Watkins PB, Adkins K, Harrill AH Toxicological sciences : an official journal of the Society of Toxicology 24848797 Toxicol Sci 2014 Aug 1
Potential serum biomarkers from a metabolomics study of autism. Wang H, Liang S, Wang M, Gao J, Sun C, Wang J, Xia W, Wu S, Sumner SJ, Zhang F, Sun C, Wu L Journal of psychiatry & neuroscience : JPN 26395811 J Psychiatry Neurosci 2016 Jan
The role of gut microbial community and metabolomic shifts in adaptive resistance of Atlantic killifish (Fundulus heteroclitus) to polycyclic aromatic hydrocarbons. Redfern LK, Jayasundara N, Singleton DR, Di Giulio RT, Carlson J, Sumner SJ, Gunsch CK The Science of the total environment 33647645 Sci Total Environ 2021 Jul 1
Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study. Harville EW, Li YY, Pan K, McRitchie S, Pathmasiri W, Sumner S Scientific reports 33568690 Sci Rep 2021 Feb 10
Microfluidics meets metabolomics to reveal the impact of Campylobacter jejuni infection on biochemical pathways. Mortensen NP, Mercier KA, McRitchie S, Cavallo TB, Pathmasiri W, Stewart D, Sumner SJ Biomedical microdevices 27231016 Biomed Microdevices 2016 Jun
Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine. Fennell TR, Mortensen NP, Black SR, Snyder RW, Levine KE, Poitras E, Harrington JM, Wingard CJ, Holland NA, Pathmasiri W, Sumner SC Journal of applied toxicology : JAT 27696470 J Appl Toxicol 2017 May
Stable Isotope-Resolved Metabolomic Differences between Hormone-Responsive and Triple-Negative Breast Cancer Cell Lines. Winnike JH, Stewart DA, Pathmasiri WW, McRitchie SL, Sumner SJ International journal of breast cancer 30363973 Int J Breast Cancer 2018
Pulmonary instillation of multi-walled carbon nanotubes promotes coronary vasoconstriction and exacerbates injury in isolated hearts. Thompson LC, Frasier CR, Sloan RC, Mann EE, Harrison BS, Brown JM, Brown DA, Wingard CJ Nanotoxicology 23102262 Nanotoxicology 2014 Feb
Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry. Harrington JM, Young DJ, Fry RC, Weber FX, Sumner SS, Levine KE Biological trace element research 26155965 Biol Trace Elem Res 2016 Feb
Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study. Loeser RF, Pathmasiri W, Sumner SJ, McRitchie S, Beavers D, Saxena P, Nicklas BJ, Jordan J, Guermazi A, Hunter DJ, Messier SP Osteoarthritis and cartilage 27012755 Osteoarthritis Cartilage 2016 Aug
The Effects of Glaucoma Drainage Devices on Oxygen Tension, Glycolytic Metabolites, and Metabolomics Profile of Aqueous Humor in the Rabbit. Williamson BK, Hawkey NM, Blake DA, Frenkel JW, McDaniel KP, Davis JK, Satija C, Beazer A, Dhungana S, Carlson J, McRitchie S, Ayyala RS Translational vision science & technology 29423340 Transl Vis Sci Technol 2018 Feb
Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants. Hoen AG, Coker MO, Madan JC, Pathmasiri W, McRitchie S, Dade EF, Doherty BT, Sumner S, Karagas MR Metabolites 34677417 Metabolites 2021 Oct 13
Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants. Karagas MR, McRitchie S, Hoen AG, Takigawa C, Jackson B, Baker ER, Madan J, Sumner SJ, Pathmasiri W Exposure and health 36776720 Expo Health 2022 Dec
Mass spectral fragmentation of trimethylsilylated small molecules. Lai Z, Fiehn O Mass spectrometry reviews 27580014 Mass Spectrom Rev 2018 May
Confounding factors in identification of disease-resilient individuals. Rosenblatt DS, Watkins D, Rajabi F, Levy HL Nature biotechnology 27824855 Nat Biotechnol 2016 Nov 8
Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous Substrates. Zhao Y, Wan D, Yang J, Hammock BD, Ortiz de Montellano PR Drug metabolism and disposition: the biological fate of chemicals 26936974 Drug Metab Dispos 2016 May
Contemporary views on the genetics of anorexia nervosa. Shih PA, Woodside DB European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 26944296 Eur Neuropsychopharmacol 2016 Apr
Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD Toxicology and applied pharmacology 25827057 Toxicol Appl Pharmacol 2015 Jul 15
Immune checkpoint blockade therapy for bladder cancer treatment. Kim J Investigative and clinical urology 27326412 Investig Clin Urol 2016 Jun
Association between plasma endocannabinoids and appetite in hemodialysis patients: A pilot study. Friedman AN, Kim J, Kaiser S, Pedersen TL, Newman JW, Watkins BA Nutrition research (New York, N.Y.) 27333956 Nutr Res 2016 Jul
Metabolomics insights into pathophysiological mechanisms of interstitial cystitis. Fiehn O, Kim J International neurourology journal 25279237 Int Neurourol J 2014 Sep
Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F Journal of the American Heart Association 25146704 J Am Heart Assoc 2014 Aug 21
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hayashi G, Shen Y, Pedersen TL, Newman JW, Pook M, Cortopassi G Human molecular genetics 25104852 Hum Mol Genet 2014 Dec 20
Tracing flavonoid degradation in grapes by MS filtering with stable isotopes. Chassy AW, Bueschl C, Lee H, Lerno L, Oberholster A, Barile D, Schuhmacher R, Waterhouse AL Food chemistry 25053079 Food Chem 2015 Jan 1
Comparative evaluation of extraction methods for simultaneous mass-spectrometric analysis of complex lipids and primary metabolites from human blood plasma. Lee DY, Kind T, Yoon YR, Fiehn O, Liu KH Analytical and bioanalytical chemistry 25171832 Anal Bioanal Chem 2014 Nov
Rapid-throughput glycomics applied to human milk oligosaccharide profiling for large human studies. Totten SM, Wu LD, Parker EA, Davis JC, Hua S, Stroble C, Ruhaak LR, Smilowitz JT, German JB, Lebrilla CB Analytical and bioanalytical chemistry 25358913 Anal Bioanal Chem 2014 Dec
Top-down analysis of highly post-translationally modified peptides by Fourier transform ion cyclotron resonance mass spectrometry. Guerrero A, Lerno L, Barile D, Lebrilla CB Journal of the American Society for Mass Spectrometry 25404158 J Am Soc Mass Spectrom 2015 Mar
Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Ono E, Dutile S, Kazani S, Wechsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland ER, Castro M, Jarjour NN, Israel E, Levy BD, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network American journal of respiratory and critical care medicine 25162465 Am J Respir Crit Care Med 2014 Oct 15
Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry. Cajka T, Fiehn O Trends in analytical chemistry : TRAC 25309011 Trends Analyt Chem 2014 Oct 1
Acute and chronic plasma metabolomic and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder. Gautam A, D'Arpa P, Donohue DE, Muhie S, Chakraborty N, Luke BT, Grapov D, Carroll EE, Meyerhoff JL, Hammamieh R, Jett M PloS one 25629821 PLoS One 2015
Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis. Armstrong AW, Wu J, Johnson MA, Grapov D, Azizi B, Dhillon J, Fiehn O F1000Research 25580230 F1000Res 2014
Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. Smilowitz JT, Zivkovic AM, Wan YJ, Watkins SM, Nording ML, Hammock BD, German JB Molecular nutrition & food research 23818328 Mol Nutr Food Res 2013 Aug
Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Schuchardt JP, Schmidt S, Kressel G, Willenberg I, Hammock BD, Hahn A, Schebb NH Prostaglandins, leukotrienes, and essential fatty acids 24411718 Prostaglandins Leukot Essent Fatty Acids 2014 Feb-Mar
Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures. Meissen JK, Hirahatake KM, Adams SH, Fiehn O Metabolomics : Official journal of the Metabolomic Society 26190955 Metabolomics 2015 Jun 1
Differential responses of human dendritic cells to metabolites from the oral/airway microbiome. Whiteson K, Agrawal S, Agrawal A Clinical and experimental immunology 28194750 Clin Exp Immunol 2017 Jun
Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Goswami SK, Rand AA, Wan D, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang GY, Hammock BD Life sciences 28522175 Life Sci 2017 Jul 1
Luteal Lipids Regulate Progesterone Production and May Modulate Immune Cell Function During the Estrous Cycle and Pregnancy. Hughes CHK, Bosviel R, Newman JW, Pate JL Frontiers in endocrinology 31636603 Front Endocrinol (Lausanne) 2019
Utilizing machine learning to discern hidden clinical values from big data in urology. Kim WJ, Jin P, Kim WH, Kim J Investigative and clinical urology 32377598 Investig Clin Urol 2020 May
Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado MR, Yang J, Hammock BD, Hankinson O Scientific reports 32398692 Sci Rep 2020 May 12
Plasma Oxylipin Profile Discriminates Ethnicities in Subjects with Non-Alcoholic Steatohepatitis: An Exploratory Analysis. Mazi TA, Borkowski K, Fiehn O, Bowlus CL, Sarkar S, Matsukuma K, Ali MR, Kieffer DA, Wan YY, Stanhope KL, Havel PJ, Newman JW, Medici V Metabolites 35208265 Metabolites 2022 Feb 19
Prediction of the Immune Phenotypes of Bladder Cancer Patients for Precision Oncology. Cho H, Tong F, You S, Jung S, Kim WH, Kim J IEEE open journal of engineering in medicine and biology 35519421 IEEE Open J Eng Med Biol 2022
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Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia. Fong LY, Jing R, Smalley KJ, Taccioli C, Fahrmann J, Barupal DK, Alder H, Farber JL, Fiehn O, Croce CM Oncotarget 29137232 Oncotarget 2017 Oct 10
Validating Quantitative Untargeted Lipidomics Across Nine Liquid Chromatography-High-Resolution Mass Spectrometry Platforms. Cajka T, Smilowitz JT, Fiehn O Analytical chemistry 29064229 Anal Chem 2017 Nov 21
Generation and quality control of lipidomics data for the alzheimer's disease neuroimaging initiative cohort. Barupal DK, Fan S, Wancewicz B, Cajka T, Sa M, Showalter MR, Baillie R, Tenenbaum JD, Louie G, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium, Kaddurah-Daouk R, Fiehn O Scientific data 30457571 Sci Data 2018 Nov 20
Epidermal growth factor expression as a predictor of chemotherapeutic resistance in muscle-invasive bladder cancer. Mansour AM, Abdelrahim M, Laymon M, Elsherbeeny M, Sultan M, Shokeir A, Mosbah A, Abol-Enein H, Awadalla A, Cho E, Sairam V, Park TD, Shahid M, Kim J BMC urology 30413194 BMC Urol 2018 Nov 9
Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. Sundberg JP, Shen T, Fiehn O, Rice RH, Silva KA, Kennedy VE, Gott NE, Dionne LA, Bechtold LS, Murray SA, Kuiper R, Pratt CH PloS one 30372477 PLoS One 2018
Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM Proceedings of the National Academy of Sciences of the United States of America 30397150 Proc Natl Acad Sci U S A 2018 Nov 20
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Eosinophilic and Noneosinophilic Asthma. Carr TF, Zeki AA, Kraft M American journal of respiratory and critical care medicine 28910134 Am J Respir Crit Care Med 2018 Jan 1
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Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, Lee J, Wolfgang MJ, Patti GJ, Finck BN, Pearce EL, Bhattacharya D Immunity 27396958 Immunity 2016 Jul 19
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Effectiveness of a Tailored Colorectal Cancer Educational Seminar in Enhancing the Awareness, Knowledge, and Behavior of Korean Americans Living in the Los Angeles Koreatown Area. Kim S, Yeon A, Cho E, Shahid M, Kim J Diversity and equality in health and care 31019695 Divers Equal Health Care 2019
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Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study. Liesenfeld DB, Grapov D, Fahrmann JF, Salou M, Scherer D, Toth R, Habermann N, Böhm J, Schrotz-King P, Gigic B, Schneider M, Ulrich A, Herpel E, Schirmacher P, Fiehn O, Lampe JW, Ulrich CM The American journal of clinical nutrition 26156741 Am J Clin Nutr 2015 Aug
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Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction. Piccolo BD, Keim NL, Fiehn O, Adams SH, Van Loan MD, Newman JW The Journal of nutrition 25833772 J Nutr 2015 Apr
Draft Genome Sequences of Salmonella Lysozyme Gene Knockout Mutants. Arabyan N, Huang BC, Weimer BC Genome announcements 28596411 Genome Announc 2017 Jun 8
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Multiplatform Mass Spectrometry-Based Approach Identifies Extracellular Glycolipids of the Yeast Rhodotorula babjevae UCDFST 04-877. Cajka T, Garay LA, Sitepu IR, Boundy-Mills KL, Fiehn O Journal of natural products 27669091 J Nat Prod 2016 Oct 28
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Combined Effects of Gestational Phthalate Exposure and Zinc Deficiency on Steroid Metabolism and Growth. Nuttall JR, Kucera HR, Supasai S, Gaikwad NW, Oteiza PI Toxicological sciences : an official journal of the Society of Toxicology 28115639 Toxicol Sci 2017 Apr 1
Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival. Fahrmann JF, Grapov D, Phinney BS, Stroble C, DeFelice BC, Rom W, Gandara DR, Zhang Y, Fiehn O, Pass H, Miyamoto S Clinical proteomics 27799870 Clin Proteomics 2016
Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers. Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD The Journal of pharmacology and experimental therapeutics 26989141 J Pharmacol Exp Ther 2016 Jun
Mass Spectral Feature List Optimizer (MS-FLO): A Tool To Minimize False Positive Peak Reports in Untargeted Liquid Chromatography-Mass Spectroscopy (LC-MS) Data Processing. DeFelice BC, Mehta SS, Samra S, Čajka T, Wancewicz B, Fahrmann JF, Fiehn O Analytical chemistry 28225594 Anal Chem 2017 Mar 21
Interstitial Cystitis-Associated Urinary Metabolites Identified by Mass-Spectrometry Based Metabolomics Analysis. Kind T, Cho E, Park TD, Deng N, Liu Z, Lee T, Fiehn O, Kim J Scientific reports 27976711 Sci Rep 2016 Dec 15
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A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. Shahin MH, Gong Y, McDonough CW, Rotroff DM, Beitelshees AL, Garrett TJ, Gums JG, Motsinger-Reif A, Chapman AB, Turner ST, Boerwinkle E, Frye RF, Fiehn O, Cooper-DeHoff RM, Kaddurah-Daouk R, Johnson JA Hypertension (Dallas, Tex. : 1979) 27381900 Hypertension 2016 Sep
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Hydrogen Rearrangement Rules: Computational MS/MS Fragmentation and Structure Elucidation Using MS-FINDER Software. Tsugawa H, Kind T, Nakabayashi R, Yukihira D, Tanaka W, Cajka T, Saito K, Fiehn O, Arita M Analytical chemistry 27419259 Anal Chem 2016 Aug 16
Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Nagy-Szakal D, Barupal DK, Lee B, Che X, Williams BL, Kahn EJR, Ukaigwe JE, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Levin B, Hornig M, Fiehn O, Lipkin WI Scientific reports 29968805 Sci Rep 2018 Jul 3
The Microbiome and Metabolome of Preterm Infant Stool Are Personalized and Not Driven by Health Outcomes, Including Necrotizing Enterocolitis and Late-Onset Sepsis. Wandro S, Osborne S, Enriquez C, Bixby C, Arrieta A, Whiteson K mSphere 29875143 mSphere 2018 Jun 27
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LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment. Kamleh MA, Snowden SG, Grapov D, Blackburn GJ, Watson DG, Xu N, Ståhle M, Wheelock CE Journal of proteome research 25361234 J Proteome Res 2015 Jan 2
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Using fragmentation trees and mass spectral trees for identifying unknown compounds in metabolomics. Vaniya A, Fiehn O Trends in analytical chemistry : TRAC 26213431 Trends Analyt Chem 2015 Jun 1
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Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis. Jeong P, Ha YS, Yun SJ, Yoon HY, Freeman MR, Kim J, Kim WJ BMC urology 26250800 BMC Urol 2015 Aug 7
Infant Maturity at Birth Reveals Minor Differences in the Maternal Milk Metabolome in the First Month of Lactation. Spevacek AR, Smilowitz JT, Chin EL, Underwood MA, German JB, Slupsky CM The Journal of nutrition 26041675 J Nutr 2015 Aug
Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: impact of a fitness and weight loss intervention. Grapov D, Fiehn O, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Hoppel CL, Harper ME, Adams SH American journal of physiology. Endocrinology and metabolism 31526287 Am J Physiol Endocrinol Metab 2019 Dec 1
Walnuts change lipoprotein composition suppressing TNFα-stimulated cytokine production by diabetic adipocyte. Borkowski K, Yim SJ, Holt RR, Hackman RM, Keen CL, Newman JW, Shearer GC The Journal of nutritional biochemistry 31030167 J Nutr Biochem 2019 Jun
Effects of Gut Bacteria Depletion and High-Na(+) and Low-K(+) Intake on Circulating Levels of Biogenic Amines. Blaženović I, Oh YT, Li F, Ji J, Nguyen AK, Wancewicz B, Bender JM, Fiehn O, Youn JH Molecular nutrition & food research 30513547 Mol Nutr Food Res 2019 Feb
Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: application in rats and humans. Zhang J, Bhattacharyya S, Hickner RC, Light AR, Lambert CJ, Gale BK, Fiehn O, Adams SH American journal of physiology. Endocrinology and metabolism 30398905 Am J Physiol Endocrinol Metab 2019 Jan 1
Noninvasive profiling of sweat-derived lipid mediators for cutaneous research. Agrawal K, Sivamani RK, Newman JW Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 30030941 Skin Res Technol 2019 Jan
Cystic Fibrosis-Associated Stenotrophomonas maltophilia Strain-Specific Adaptations and Responses to pH. Gallagher T, Phan J, Oliver A, Chase AB, England WE, Wandro S, Hendrickson C, Riedel SF, Whiteson K Journal of bacteriology 30642989 J Bacteriol 2019 Apr 1
Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Deol P, Fahrmann J, Yang J, Evans JR, Rizo A, Grapov D, Salemi M, Wanichthanarak K, Fiehn O, Phinney B, Hammock BD, Sladek FM Scientific reports 28970503 Sci Rep 2017 Oct 2
Quantitative Proteomic Analysis Reveals Caffeine-Perturbed Proteomic Profiles in Normal Bladder Epithelial Cells. Shahid M, Kim M, Yeon A, Andres AM, You S, Kim J Proteomics 30232827 Proteomics 2018 Oct
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Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Schuchardt JP, Schmidt S, Kressel G, Dong H, Willenberg I, Hammock BD, Hahn A, Schebb NH Prostaglandins, leukotrienes, and essential fatty acids 23694766 Prostaglandins Leukot Essent Fatty Acids 2013 Jul
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Oxylipin responses to fasting and insulin infusion in a large mammalian model of fasting-induced insulin resistance, the northern elephant seal. Wright DN, Katundu KGH, Viscarra JA, Crocker DE, Newman JW, La Frano MR, Ortiz RM American journal of physiology. Regulatory, integrative and comparative physiology 34346724 Am J Physiol Regul Integr Comp Physiol 2021 Oct 1
Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology. Kim J, Yeon A, Parker SJ, Shahid M, Thiombane A, Cho E, You S, Emam H, Kim DG, Kim M International journal of medical sciences 34400895 Int J Med Sci 2021
Lipid remodeling in response to methionine stress in MDA-MBA-468 triple-negative breast cancer cells. Borrego SL, Fahrmann J, Hou J, Lin DW, Tromberg BJ, Fiehn O, Kaiser P Journal of lipid research 33647277 J Lipid Res 2021
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Mid-gestation serum lipidomic profile associations with spontaneous preterm birth are influenced by body mass index. Borkowski K, Newman JW, Aghaeepour N, Mayo JA, Blazenović I, Fiehn O, Stevenson DK, Shaw GM, Carmichael SL PloS one 33201881 PLoS One 2020
Proteomic profiling of bladder cancer for precision medicine in the clinical setting: A review for the busy urologist. Kim J, Jin P, Yang W, Kim WJ Investigative and clinical urology 33135400 Investig Clin Urol 2020 Nov
Stress-Induced Accumulation of HnRNP K into Stress Granules. Kim J, Yeon A, Kim WK, Kim KH, Ohn T Journal of cancer science and clinical therapeutics 35340804 J Cancer Sci Clin Ther 2021
Determinants of Meal-Induced Changes in Circulating FFA Epoxides, Diols, and Diol-to-Epoxide Ratios as Indices of Soluble Epoxide Hydrolase Activity. Oh YT, Yang J, Stefanovski D, Hammock B, Youn JH International journal of molecular sciences 38139180 Int J Mol Sci 2023 Dec 11
Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice. Deol P, Ruegger P, Logan GD, Shawki A, Li J, Mitchell JD, Yu J, Piamthai V, Radi SH, Hasnain S, Borkowski K, Newman JW, McCole DF, Nair MG, Hsiao A, Borneman J, Sladek FM Gut microbes 37400966 Gut Microbes 2023 Jan-Dec
Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. Frolov A, Dong H, Jiang M, Yang L, Cook EC, Matnani R, Hammock BD, Crofford LJ The Journal of biological chemistry 23814065 J Biol Chem 2013 Aug 16
Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D The Journal of experimental biology 24072790 J Exp Biol 2013 Dec 15
Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. Yang J, Solaimani P, Dong H, Hammock B, Hankinson O The Journal of toxicological sciences 24213002 J Toxicol Sci 2013
Human milk secretory immunoglobulin a and lactoferrin N-glycans are altered in women with gestational diabetes mellitus. Smilowitz JT, Totten SM, Huang J, Grapov D, Durham HA, Lammi-Keefe CJ, Lebrilla C, German JB The Journal of nutrition 24047700 J Nutr 2013 Dec
Tracing phenolic metabolism in Vitis vinifera berries with 13C6-phenylalanine: implication of an unidentified intermediate reservoir. Chassy AW, Adams DO, Waterhouse AL Journal of agricultural and food chemistry 24611798 J Agric Food Chem 2014 Mar 19
Accumulation of high-value lipids in single-cell microorganisms: a mechanistic approach and future perspectives. Garay LA, Boundy-Mills KL, German JB Journal of agricultural and food chemistry 24628496 J Agric Food Chem 2014 Apr 2
Identifying individual differences of fluoxetine response in juvenile rhesus monkeys by metabolite profiling. He Y, Hogrefe CE, Grapov D, Palazoglu M, Fiehn O, Turck CW, Golub MS Translational psychiatry 25369145 Transl Psychiatry 2014 Nov 4
Gastrointestinal microbes interact with canine adipose-derived mesenchymal stem cells in vitro and enhance immunomodulatory functions. Kol A, Foutouhi S, Walker NJ, Kong NT, Weimer BC, Borjesson DL Stem cells and development 24803072 Stem Cells Dev 2014 Aug 15
Perinatal exposure of mice to the pesticide DDT impairs energy expenditure and metabolism in adult female offspring. La Merrill M, Karey E, Moshier E, Lindtner C, La Frano MR, Newman JW, Buettner C PloS one 25076055 PLoS One 2014
Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. Campbell C, Grapov D, Fiehn O, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Gustafson MB, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Harper ME, Hoppel CL, Meissen JK, Take K, Adams SH PloS one 24416208 PLoS One 2014
Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Schuchardt JP, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, Schebb NH Prostaglandins & other lipid mediators 24667634 Prostaglandins Other Lipid Mediat 2014 Jun
Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. Nording ML, Yang J, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM PloS one 24204640 PLoS One 2013
Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice. Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ Prostaglandins, leukotrienes, and essential fatty acids 24055573 Prostaglandins Leukot Essent Fatty Acids 2013 Oct
Prebiotic Oligosaccharides Potentiate Host Protective Responses against L. Monocytogenes Infection. Chen P, Reiter T, Huang B, Kong N, Weimer BC Pathogens (Basel, Switzerland) 29257110 Pathogens 2017 Dec 19
Comprehensive comparison of in silico MS/MS fragmentation tools of the CASMI contest: database boosting is needed to achieve 93% accuracy. Blaženović I, Kind T, Torbašinović H, Obrenović S, Mehta SS, Tsugawa H, Wermuth T, Schauer N, Jahn M, Biedendieck R, Jahn D, Fiehn O Journal of cheminformatics 29086039 J Cheminform 2017 May 25
Obesity-induced changes in lipid mediators persist after weight loss. Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O International journal of obesity (2005) 29089614 Int J Obes (Lond) 2018 Apr
Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils. Richardson CE, Hennebelle M, Otoki Y, Zamora D, Yang J, Hammock BD, Taha AY Journal of agricultural and food chemistry 28157307 J Agric Food Chem 2017 Mar 8
Site-specific glycosylation of secretory immunoglobulin A from human colostrum. Huang J, Guerrero A, Parker E, Strum JS, Smilowitz JT, German JB, Lebrilla CB Journal of proteome research 25629924 J Proteome Res 2015 Mar 6
Metabolomics by Gas Chromatography-Mass Spectrometry: Combined Targeted and Untargeted Profiling. Fiehn O Current protocols in molecular biology 27038389 Curr Protoc Mol Biol 2016 Apr 1
Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure. Nording ML, Yang J, Hoang L, Zamora V, Uyeminami D, Espiritu I, Pinkerton KE, Hammock BD, Luria A Journal of metabolomics 27076918 J Metabolomics 2015 Apr
Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus. Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP Frontiers in microbiology 28536571 Front Microbiol 2017
LipidBlast templates as flexible tools for creating new in-silico tandem mass spectral libraries. Kind T, Okazaki Y, Saito K, Fiehn O Analytical chemistry 25340521 Anal Chem 2014 Nov 18
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L Clinical and experimental pharmacology & physiology 25224811 Clin Exp Pharmacol Physiol 2014 Dec
Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury. Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD Molecular pharmacology 29844231 Mol Pharmacol 2018 Aug
Celecoxib use and circulating oxylipins in a colon polyp prevention trial. Martinez JA, Yang J, Wertheim BC, Roe DJ, Schriewer A, Lance P, Alberts DS, Hammock BD, Thompson PA PloS one 29698447 PLoS One 2018
Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation. Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Hegedus Karbowski C, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM PloS one 26672987 PLoS One 2015
Ultrafast Polyphenol Metabolomics of Red Wines Using MicroLC-MS/MS. Ma Y, Tanaka N, Vaniya A, Kind T, Fiehn O Journal of agricultural and food chemistry 26698107 J Agric Food Chem 2016 Jan 20
Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W Journal of hepatology 26220752 J Hepatol 2016 Jan
Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. Červenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, Hwang SH, Hammock BD, Imig JD, Sadowski J Physiological research 26047375 Physiol Res 2015
Genomic, Proteomic, and Metabolomic Data Integration Strategies. Wanichthanarak K, Fahrmann JF, Grapov D Biomarker insights 26396492 Biomark Insights 2015
Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases. Moon JY, Choi MH, Kim J Endocrine-related cancer 27580660 Endocr Relat Cancer 2016 Oct
Integrated Metabolomics and Proteomics Highlight Altered Nicotinamide- and Polyamine Pathways in Lung Adenocarcinoma. Fahrmann JF, Grapov DD, Wanichthanarak K, DeFelice BC, Salemi MR, Rom WN, Gandara DR, Phinney BS, Fiehn O, Pass H, Miyamoto S Carcinogenesis 28049629 Carcinogenesis 2017 Mar
Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit. McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR Journal of ocular biology 28066796 J Ocul Biol 2016 Jan
An ω-3-enriched diet alone does not attenuate CCl(4)-induced hepatic fibrosis. Harris TR, Kodani S, Yang J, Imai DM, Hammock BD The Journal of nutritional biochemistry 27732914 J Nutr Biochem 2016 Dec
MINEs: open access databases of computationally predicted enzyme promiscuity products for untargeted metabolomics. Jeffryes JG, Colastani RL, Elbadawi-Sidhu M, Kind T, Niehaus TD, Broadbelt LJ, Hanson AD, Fiehn O, Tyo KE, Henry CS Journal of cheminformatics 26322134 J Cheminform 2015
Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Green AJ, Graham JL, Gonzalez EA, La Frano MR, Petropoulou SE, Park JS, Newman JW, Stanhope KL, Havel PJ, La Merrill MA Reproductive toxicology (Elmsford, N.Y.) 27421578 Reprod Toxicol 2017 Mar
Circulating levels of endocannabinoids and oxylipins altered by dietary lipids in older women are likely associated with previously identified gene targets. Watkins BA, Kim J, Kenny A, Pedersen TL, Pappan KL, Newman JW Biochimica et biophysica acta 27452639 Biochim Biophys Acta 2016 Nov
Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. Sun L, Beggs K, Borude P, Edwards G, Bhushan B, Walesky C, Roy N, Manley MW Jr, Gunewardena S, O'Neil M, Li H, Apte U American journal of physiology. Gastrointestinal and liver physiology 27151938 Am J Physiol Gastrointest Liver Physiol 2016 Jul 1
Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. Fahrmann J, Grapov D, Yang J, Hammock B, Fiehn O, Bell GI, Hara M American journal of physiology. Endocrinology and metabolism 25852003 Am J Physiol Endocrinol Metab 2015 Jun 1
Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. Midtbø LK, Borkowska AG, Bernhard A, Rønnevik AK, Lock EJ, Fitzgerald ML, Torstensen BE, Liaset B, Brattelid T, Pedersen TL, Newman JW, Kristiansen K, Madsen L The Journal of nutritional biochemistry 25776459 J Nutr Biochem 2015 Jun
Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Faber F, Tran L, Byndloss MX, Lopez CA, Velazquez EM, Kerrinnes T, Nuccio SP, Wangdi T, Fiehn O, Tsolis RM, Bäumler AJ Nature 27309805 Nature 2016 Jun 30
Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids. Shearer GC, Borkowski K, Puumala SL, Harris WS, Pedersen TL, Newman JW Prostaglandins, leukotrienes, and essential fatty acids 29413356 Prostaglandins Leukot Essent Fatty Acids 2018 Jan
Obesogenic diets alter metabolism in mice. Showalter MR, Nonnecke EB, Linderholm AL, Cajka T, Sa MR, Lönnerdal B, Kenyon NJ, Fiehn O PloS one 29324762 PLoS One 2018
Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance. Olmstead KI, La Frano MR, Fahrmann J, Grapov D, Viscarra JA, Newman JW, Fiehn O, Crocker DE, Filipp FV, Ortiz RM Metabolomics : Official journal of the Metabolomic Society 28757815 Metabolomics 2017 May
An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats. Minaz N, Razdan R, Hammock BD, Goswami SK Prostaglandins & other lipid mediators 29751149 Prostaglandins Other Lipid Mediat 2018 May
Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A. Shahid M, Gull N, Yeon A, Cho E, Bae J, Yoon HS, You S, Yoon H, Kim M, Berman BP, Kim J Scientific reports 29540744 Sci Rep 2018 Mar 14
The serum metabolomics signature of type 2 diabetes is obscured in Alzheimer's disease. Morris JK, Piccolo BD, Shankar K, Thyfault JP, Adams SH American journal of physiology. Endocrinology and metabolism 29351484 Am J Physiol Endocrinol Metab 2018 Jun 1
Unique plasma metabolomic signatures of individuals with inherited disorders of long-chain fatty acid oxidation. McCoin CS, Piccolo BD, Knotts TA, Matern D, Vockley J, Gillingham MB, Adams SH Journal of inherited metabolic disease 26907176 J Inherit Metab Dis 2016 May
Pharmacometabolomic signature links simvastatin therapy and insulin resistance. Elbadawi-Sidhu M, Baillie RA, Zhu H, Chen YI, Goodarzi MO, Rotter JI, Krauss RM, Fiehn O, Kaddurah-Daouk R Metabolomics : Official journal of the Metabolomic Society 29732238 Metabolomics 2017 Jan
Exogenous GLP-1 stimulates TCA cycle and suppresses gluconeogenesis and ketogenesis in late-fasted northern elephant seals pups. Dhillon J, Viscarra JA, Newman JW, Fiehn O, Crocker DE, Ortiz RM American journal of physiology. Regulatory, integrative and comparative physiology 33407018 Am J Physiol Regul Integr Comp Physiol 2021 Apr 1
Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries. Leslie E, Lopez V, Anti NAO, Alvarez R, Kafeero I, Welsh DG, Romero M, Kaushal S, Johnson CM, Bosviel R, Blaženović I, Song R, Brito A, Frano MR, Zhang L, Newman JW, Fiehn O, Wilson SM American journal of physiology. Lung cellular and molecular physiology 33624555 Am J Physiol Lung Cell Mol Physiol 2021 May 1
Equality, Inclusion, and Diversity in Healthcare During the COVID-19 Pandemic. Kim J International neurourology journal 32615681 Int Neurourol J 2020 Jun
Teleurology and digital health app in COVID-19 pandemic. Kim J, Gewertz B Investigative and clinical urology 32665988 Investig Clin Urol 2020 Jul
Quick overview of diagnostic kits and smartphone apps for urologists during the COVID-19 pandemic: a narrative review. Park H, Jin P, Jung S, Kim J Translational andrology and urology 33718094 Transl Androl Urol 2021 Feb
Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension. La Frano MR, Fahrmann JF, Grapov D, Pedersen TL, Newman JW, Fiehn O, Underwood MA, Mestan K, Steinhorn RH, Wedgwood S American journal of physiology. Lung cellular and molecular physiology 30113229 Am J Physiol Lung Cell Mol Physiol 2018 Nov 1
Using MS-FINDER for identifying 19 natural products in the CASMI 2016 contest. Vaniya A, Samra SN, Palazoglu M, Tsugawa H, Fiehn O Phytochemistry letters 31576201 Phytochem Lett 2017 Sep
α-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation. Fan R, Kim J, You M, Giraud D, Toney AM, Shin SH, Kim SY, Borkowski K, Newman JW, Chung S The Journal of nutritional biochemistry 31760228 J Nutr Biochem 2020 Feb
Innovative technologies for the smart E-Healthcare system. Kim WJ, Kim J Investigative and clinical urology 30637354 Investig Clin Urol 2019 Jan
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD Proceedings of the National Academy of Sciences of the United States of America 28396419 Proc Natl Acad Sci U S A 2017 Apr 25
Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. Tian J, Zhu J, Yi Y, Li C, Zhang Y, Zhao Y, Pan C, Xiang S, Li X, Li G, Newman JW, Feng X, Liu J, Han J, Wang L, Gao Y, La Frano MR, Liang A Scientific reports 28827769 Sci Rep 2017 Aug 21
Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor. Minaz N, Razdan R, Hammock BD, Mujwar S, Goswami SK Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 31102913 Biomed Pharmacother 2019 Jul
MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome. Vogel Ciernia A, Yasui DH, Pride MC, Durbin-Johnson B, Noronha AB, Chang A, Knotts TA, Rutkowsky JR, Ramsey JJ, Crawley JN, LaSalle JM Human molecular genetics 30137367 Hum Mol Genet 2018 Dec 1
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Rajan MR, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton NJ, Biörserud C, Lindahl TL, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman JW, Perkins R, Wallenius V, Lange S, Börgeson E Scientific reports 31659186 Sci Rep 2019 Oct 28
Abrogation of esophageal carcinoma development in miR-31 knockout rats. Fong LY, Taccioli C, Palamarchuk A, Tagliazucchi GM, Jing R, Smalley KJ, Fan S, Altemus J, Fiehn O, Huebner K, Farber JL, Croce CM Proceedings of the National Academy of Sciences of the United States of America 32123074 Proc Natl Acad Sci U S A 2020 Mar 17
Multiassay nutritional metabolomics profiling of low vitamin A status versus adequacy is characterized by reduced plasma lipid mediators among lactating women in the Philippines: A pilot study. Johnson CM, Rosario R, Brito A, Agrawal K, Fanter R, Lietz G, Haskell M, Engle-Stone R, Newman JW, La Frano MR Nutrition research (New York, N.Y.) 35732076 Nutr Res 2022 Aug
Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures. Soták M, Rajan MR, Clark M, Harms M, Rani A, Kraft JD, Tandio D, Shen T, Borkowski K, Fiehn O, Newman JW, Quiding-Järbrink M, Biörserud C, Apelgren P, Staalesen T, Hagberg CE, Boucher J, Wallenius V, Lange S, Börgeson E iScience 35789845 iScience 2022 Jul 15
Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women. Grapov D, Fiehn O, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Keim NL, Hunter GR, Fernandez JR, Garvey WT, Hoppel CL, Harper ME, Newman JW, Adams SH Physiological reports 32869956 Physiol Rep 2020 Sep
Urinary metabolite profiling combined with computational analysis predicts interstitial cystitis-associated candidate biomarkers. Wen H, Lee T, You S, Park SH, Song H, Eilber KS, Anger JT, Freeman MR, Park S, Kim J Journal of proteome research 25353990 J Proteome Res 2015 Jan 2
Enhanced detection and identification in metabolomics by use of LC-MS/MS untargeted analysis in combination with gas-phase fractionation. Calderón-Santiago M, Priego-Capote F, Luque de Castro MD Analytical chemistry 24992377 Anal Chem 2014 Aug 5
Gene expression profiling in pachyonychia congenita skin. Cao YA, Hickerson RP, Seegmiller BL, Grapov D, Gross MM, Bessette MR, Phinney BS, Flores MA, Speaker TJ, Vermeulen A, Bravo AA, Bruckner AL, Milstone LM, Schwartz ME, Rice RH, Kaspar RL Journal of dermatological science 25656049 J Dermatol Sci 2015 Mar
Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Shih PB, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W Molecular psychiatry 25824304 Mol Psychiatry 2016 Apr
MetaMapR: pathway independent metabolomic network analysis incorporating unknowns. Grapov D, Wanichthanarak K, Fiehn O Bioinformatics (Oxford, England) 25847005 Bioinformatics 2015 Aug 15
Cardiac steatosis potentiates angiotensin II effects in the heart. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG American journal of physiology. Heart and circulatory physiology 25485904 Am J Physiol Heart Circ Physiol 2015 Feb 15
High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy. Snowden SG, Grapov D, Settergren M, D'Alexandri FL, Haeggström JZ, Fiehn O, Hyötyläinen T, Pedersen TL, Newman JW, Orešič M, Pernow J, Wheelock CE Circulation. Cardiovascular genetics 25516625 Circ Cardiovasc Genet 2014 Dec
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients? Kim J, Kim WJ Annals of translational medicine 25738138 Ann Transl Med 2015 Feb
Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. Van Bogaert I, Zhang G, Yang J, Liu JY, Ye Y, Soetaert W, Hammock BD Journal of lipid research 23966667 J Lipid Res 2013 Nov
The use of metabolomics in population-based research. Su LJ, Fiehn O, Maruvada P, Moore SC, O'Keefe SJ, Wishart DS, Zanetti KA Advances in nutrition (Bethesda, Md.) 25398741 Adv Nutr 2014 Nov
Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG PloS one 25402489 PLoS One 2014
Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Yang J, Bratt J, Franzi L, Liu JY, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD American journal of respiratory cell and molecular biology 24922186 Am J Respir Cell Mol Biol 2015 Jan
Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Schebb NH, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt JP Prostaglandins & other lipid mediators 24880049 Prostaglandins Other Lipid Mediat 2014 Oct
Oxylipin Profiling of Alzheimer's Disease in Nondiabetic and Type 2 Diabetic Elderly. Morris JK, Piccolo BD, John CS, Green ZD, Thyfault JP, Adams SH Metabolites 31491971 Metabolites 2019 Sep 5
Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment. Shahid M, Kim J Metabolites 32962184 Metabolites 2020 Sep 20
Identification of small molecules using accurate mass MS/MS search. Kind T, Tsugawa H, Cajka T, Ma Y, Lai Z, Mehta SS, Wohlgemuth G, Barupal DK, Showalter MR, Arita M, Fiehn O Mass spectrometry reviews 28436590 Mass Spectrom Rev 2018 Jul
Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Xu J, Morisseau C, Yang J, Lee KSS, Kamita SG, Hammock BD Insect biochemistry and molecular biology 27369469 Insect Biochem Mol Biol 2016 Sep
SPLASH, a hashed identifier for mass spectra. Wohlgemuth G, Mehta SS, Mejia RF, Neumann S, Pedrosa D, Pluskal T, Schymanski EL, Willighagen EL, Wilson M, Wishart DS, Arita M, Dorrestein PC, Bandeira N, Wang M, Schulze T, Salek RM, Steinbeck C, Nainala VC, Mistrik R, Nishioka T, Fiehn O Nature biotechnology 27824832 Nat Biotechnol 2016 Nov 8
Sweat lipid mediator profiling: a noninvasive approach for cutaneous research. Agrawal K, Hassoun LA, Foolad N, Pedersen TL, Sivamani RK, Newman JW Journal of lipid research 27875258 J Lipid Res 2017 Jan
Are We Ready to Use the Omics Strategies for Precision Medicine? Kim J International neurourology journal 27915470 Int Neurourol J 2016 Nov
Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Zhang J, Light AR, Hoppel CL, Campbell C, Chandler CJ, Burnett DJ, Souza EC, Casazza GA, Hughen RW, Keim NL, Newman JW, Hunter GR, Fernandez JR, Garvey WT, Harper ME, Fiehn O, Adams SH Experimental physiology 27730694 Exp Physiol 2017 Jan 1
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H Nature cell biology 26571212 Nat Cell Biol 2015 Dec
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling. Shahid M, Lee MY, Piplani H, Andres AM, Zhou B, Yeon A, Kim M, Kim HL, Kim J Cell cycle (Georgetown, Tex.) 30526248 Cell Cycle 2018
Exosomes Derived from Human Primed Mesenchymal Stem Cells Induce Mitosis and Potentiate Growth Factor Secretion. Yuan O, Lin C, Wagner J, Archard JA, Deng P, Halmai J, Bauer G, Fink KD, Fury B, Perotti NH, Walker JE, Pollock K, Apperson M, Butters J, Belafsky P, Farwell DG, Kuhn M, Nolta J, Anderson JD Stem cells and development 30638129 Stem Cells Dev 2019 Mar 15
Application of Low-Cost, Easy-to-Use, Portable Biosensor Systems for Diagnosing Bladder Dysfunctions. Myung NV, Jung S, Kim J International neurourology journal 30943698 Int Neurourol J 2019 Mar
Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects. Perroud B, Jafar-Nejad P, Wikoff WR, Gatchel JR, Wang L, Barupal DK, Crespo-Barreto J, Fiehn O, Zoghbi HY, Kaddurah-Daouk R PloS one 23936457 PLoS One 2013
Virus encoded circulatory miRNAs for early detection of prostate cancer. Kim J, Yun SJ, Kim WJ BMC urology 26612689 BMC Urol 2015 Nov 26
Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. Piccolo BD, Graham JL, Stanhope KL, Fiehn O, Havel PJ, Adams SH American journal of physiology. Endocrinology and metabolism 27094034 Am J Physiol Endocrinol Metab 2016 Jun 1
Dietary DHA reduces downstream endocannabinoid and inflammatory gene expression and epididymal fat mass while improving aspects of glucose use in muscle in C57BL/6J mice. Kim J, Carlson ME, Kuchel GA, Newman JW, Watkins BA International journal of obesity (2005) 26219414 Int J Obes (Lond) 2016 Jan
The c-MET Network as Novel Prognostic Marker for Predicting Bladder Cancer Patients with an Increased Risk of Developing Aggressive Disease. Kim YW, Yun SJ, Jeong P, Kim SK, Kim SY, Yan C, Seo SP, Lee SK, Kim J, Kim WJ PloS one 26225770 PLoS One 2015
Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non-Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B. Wikoff WR, Hanash S, DeFelice B, Miyamoto S, Barnett M, Zhao Y, Goodman G, Feng Z, Gandara D, Fiehn O, Taguchi A Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26282655 J Clin Oncol 2015 Nov 20
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Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer. Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W Cell 27133165 Cell 2016 May 19
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Bacterial nutrient foraging in a mouse model of enteral nutrient deprivation: insight into the gut origin of sepsis. Ralls MW, Demehri FR, Feng Y, Raskind S, Ruan C, Schintlmeister A, Loy A, Hanson B, Berry D, Burant CF, Teitelbaum DH American journal of physiology. Gastrointestinal and liver physiology 27586649 Am J Physiol Gastrointest Liver Physiol 2016 Oct 1
Myeloperoxidase Levels and Its Product 3-Chlorotyrosine Predict Chronic Kidney Disease Severity and Associated Coronary Artery Disease. Afshinnia F, Zeng L, Byun J, Gadegbeku CA, Magnone MC, Whatling C, Valastro B, Kretzler M, Pennathur S, Michigan Kidney Translational Core CPROBE Investigator Group American journal of nephrology 28668952 Am J Nephrol 2017
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Plasma Ceramides and Risk of Impaired Lower-Extremity Function in Older Adults: A Nested Case-Control Study. Caballero FF, Struijk EA, Buño A, Rodríguez-Artalejo F, Lopez-Garcia E The journals of gerontology. Series A, Biological sciences and medical sciences 32756936 J Gerontol A Biol Sci Med Sci 2021 Jun 14
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Maternal lipodome across pregnancy is associated with the neonatal DNA methylome. LaBarre JL, McCabe CF, Jones TR, Song PX, Domino SE, Treadwell MC, Dolinoy DC, Padmanabhan V, Burant CF, Goodrich JM Epigenomics 33290095 Epigenomics 2020 Dec
Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings. Akinci B, Subauste A, Ajluni N, Esfandiari NH, Meral R, Neidert AH, Eraslan A, Hench R, Rus D, McKenna B, Hussain HK, Chenevert TL, Tayeh MK, Rupani AR, Innis JW, Mantzoros CS, Conjeevaram HS, Burant CL, Oral EA Med (New York, N.Y.) 35291351 Med 2021 Jul 9
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Distinguishing d- and l-aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry. Zheng X, Deng L, Baker ES, Ibrahim YM, Petyuk VA, Smith RD Chemical communications (Cambridge, England) 28654112 Chem Commun (Camb) 2017 Jul 11
Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice. Singh V, Chassaing B, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M Cell metabolism 26525535 Cell Metab 2015 Dec 1
Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells. Bi H, Krausz KW, Manna SK, Li F, Johnson CH, Gonzalez FJ Analytical and bioanalytical chemistry 23604415 Anal Bioanal Chem 2013 Jun
A metabolomics investigation of non-genotoxic carcinogenicity in the rat. Ament Z, Waterman CL, West JA, Waterfield C, Currie RA, Wright J, Griffin JL Journal of proteome research 24161236 J Proteome Res 2013 Dec 6
Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome. Roberts LD, Koulman A, Griffin JL The lancet. Diabetes & endocrinology 24622670 Lancet Diabetes Endocrinol 2014 Jan
Lipid metabolism and lipophagy in cancer. Maan M, Peters JM, Dutta M, Patterson AD Biochemical and biophysical research communications 29438712 Biochem Biophys Res Commun 2018 Oct 7
The aryl hydrocarbon receptor as a moderator of host-microbiota communication. Zhang L, Nichols RG, Patterson AD Current opinion in toxicology 29527582 Curr Opin Toxicol 2017 Feb
Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism. Pathak P, Xie C, Nichols RG, Ferrell JM, Boehme S, Krausz KW, Patterson AD, Gonzalez FJ, Chiang JYL Hepatology (Baltimore, Md.) 29486523 Hepatology 2018 Oct
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ Nature communications 26670557 Nat Commun 2015 Dec 15
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, Patterson AD, Gonzalez FJ Biochimica et biophysica acta 25736301 Biochim Biophys Acta 2015 Jul
Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD Environmental health perspectives 25768209 Environ Health Perspect 2015 Jul
An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. Xie C, Jiang C, Shi J, Gao X, Sun D, Sun L, Wang T, Takahashi S, Anitha M, Krausz KW, Patterson AD, Gonzalez FJ Diabetes 28223344 Diabetes 2017 Mar
Crucial role of macrophage selenoproteins in experimental colitis. Kaushal N, Kudva AK, Patterson AD, Chiaro C, Kennett MJ, Desai D, Amin S, Carlson BA, Cantorna MT, Prabhu KS Journal of immunology (Baltimore, Md. : 1950) 25187657 J Immunol 2014 Oct 1
Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice. Zhang L, Hatzakis E, Nichols RG, Hao R, Correll J, Smith PB, Chiaro CR, Perdew GH, Patterson AD Environmental science & technology 26023891 Environ Sci Technol 2015 Jul 7
Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota. Cai J, Zhang L, Jones RA, Correll JB, Hatzakis E, Smith PB, Gonzalez FJ, Patterson AD Journal of proteome research 26696396 J Proteome Res 2016 Feb 5
Metabolomics dataset of PPAR-pan treated rat liver. Ament Z, West JA, Stanley E, Li X, Ashmore T, Roberts LD, Wright J, Nicholls AW, Griffin JL Data in brief 27331087 Data Brief 2016 Sep
A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids. Hinz C, Liggi S, Mocciaro G, Jung S, Induruwa I, Pereira M, Bryant CE, Meckelmann SW, O'Donnell VB, Farndale RW, Fjeldsted J, Griffin JL Analytical chemistry 31074960 Anal Chem 2019 Jul 2
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. Li G, Xie C, Lu S, Nichols RG, Tian Y, Li L, Patel D, Ma Y, Brocker CN, Yan T, Krausz KW, Xiang R, Gavrilova O, Patterson AD, Gonzalez FJ Cell metabolism 28918936 Cell Metab 2017 Oct 3
Metabolomics: an essential tool to understand the function of peroxisome proliferator-activated receptor alpha. Montanez JE, Peters JM, Correll JB, Gonzalez FJ, Patterson AD Toxicologic pathology 23197196 Toxicol Pathol 2013 Feb
The aryl hydrocarbon receptor activates ceramide biosynthesis in mice contributing to hepatic lipogenesis. Liu Q, Zhang L, Allman EL, Hubbard TD, Murray IA, Hao F, Tian Y, Gui W, Nichols RG, Smith PB, Anitha M, Perdew GH, Patterson AD Toxicology 34097992 Toxicology 2021 Jun 30
Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. Li F, Pang X, Krausz KW, Jiang C, Chen C, Cook JA, Krishna MC, Mitchell JB, Gonzalez FJ, Patterson AD Journal of proteome research 23301521 J Proteome Res 2013 Mar 1
Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. Tanaka N, Takahashi S, Fang ZZ, Matsubara T, Krausz KW, Qu A, Gonzalez FJ Biochimica et biophysica acta 25178843 Biochim Biophys Acta 2014 Nov
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Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ Nature medicine 29035368 Nat Med 2017 Nov
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW, Cai J, Qi Y, Fang ZZ, Takahashi S, Tanaka N, Desai D, Amin SG, Albert I, Patterson AD, Gonzalez FJ The Journal of clinical investigation 25500885 J Clin Invest 2015 Jan
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Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice. Belton KR, Tian Y, Zhang L, Anitha M, Smith PB, Perdew GH, Patterson AD Journal of proteome research 29521512 J Proteome Res 2018 Apr 6
Interplay Between the Host, the Human Microbiome, and Drug Metabolism. Nichols RG, Peters JM, Patterson AD Human genomics 31186074 Hum Genomics 2019 Jun 11
Structural and Functional Analysis of the Gut Microbiome for Toxicologists. Nichols RG, Cai J, Murray IA, Koo I, Smith PB, Perdew GH, Patterson AD Current protocols in toxicology 30230220 Curr Protoc Toxicol 2018 Nov
Aryl hydrocarbon receptor ligands in cancer: friend and foe. Murray IA, Patterson AD, Perdew GH Nature reviews. Cancer 25568920 Nat Rev Cancer 2014 Dec
Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ The Journal of biological chemistry 25605736 J Biol Chem 2015 Mar 13
Does our gut microbiome predict cardiovascular risk? A review of the evidence from metabolomics. Griffin JL, Wang X, Stanley E Circulation. Cardiovascular genetics 25691688 Circ Cardiovasc Genet 2015 Feb
Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data. Zhan X, Patterson AD, Ghosh D BMC bioinformatics 25887233 BMC Bioinformatics 2015 Mar 11
Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology. Patterson AD, Turnbaugh PJ Cell metabolism 25156450 Cell Metab 2014 Nov 4
A review of analytical platforms for accurate bile acid measurement. Dutta M, Cai J, Gui W, Patterson AD Analytical and bioanalytical chemistry 31127337 Anal Bioanal Chem 2019 Jul
PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling. Ament Z, West JA, Stanley E, Ashmore T, Roberts LD, Wright J, Nicholls AW, Griffin JL Free radical biology & medicine 26654758 Free Radic Biol Med 2016 Jun
Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. Mathé EA, Patterson AD, Haznadar M, Manna SK, Krausz KW, Bowman ED, Shields PG, Idle JR, Smith PB, Anami K, Kazandjian DG, Hatzakis E, Gonzalez FJ, Harris CC Cancer research 24736543 Cancer Res 2014 Jun 15
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Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice. Murray IA, Nichols RG, Zhang L, Patterson AD, Perdew GH Scientific reports 27659481 Sci Rep 2016 Sep 23
Multiplatform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity. Cai J, Nichols RG, Koo I, Kalikow ZA, Zhang L, Tian Y, Zhang J, Smith PB, Patterson AD mSystems 30417115 mSystems 2018 Nov-Dec
Lactate metabolism is associated with mammalian mitochondria. Chen YJ, Mahieu NG, Huang X, Singh M, Crawford PA, Johnson SL, Gross RW, Schaefer J, Patti GJ Nature chemical biology 27618187 Nat Chem Biol 2016 Nov
Defining and Detecting Complex Peak Relationships in Mass Spectral Data: The Mz.unity Algorithm. Mahieu NG, Spalding JL, Gelman SJ, Patti GJ Analytical chemistry 27513885 Anal Chem 2016 Sep 20
Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database. Zhu ZJ, Schultz AW, Wang J, Johnson CH, Yannone SM, Patti GJ, Siuzdak G Nature protocols 23391889 Nat Protoc 2013 Mar
Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Ivanisevic J, Zhu ZJ, Plate L, Tautenhahn R, Chen S, O'Brien PJ, Johnson CH, Marletta MA, Patti GJ, Siuzdak G Analytical chemistry 23781873 Anal Chem 2013 Jul 16
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Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism. Rashmi R, Huang X, Floberg JM, Elhammali AE, McCormick ML, Patti GJ, Spitz DR, Schwarz JK Cancer research 29339540 Cancer Res 2018 Mar 15
An accelerated workflow for untargeted metabolomics using the METLIN database. Tautenhahn R, Cho K, Uritboonthai W, Zhu Z, Patti GJ, Siuzdak G Nature biotechnology 22965049 Nat Biotechnol 2012 Sep
After the feature presentation: technologies bridging untargeted metabolomics and biology. Cho K, Mahieu NG, Johnson SL, Patti GJ Current opinion in biotechnology 24816495 Curr Opin Biotechnol 2014 Aug
Autonomous metabolomics for rapid metabolite identification in global profiling. Benton HP, Ivanisevic J, Mahieu NG, Kurczy ME, Johnson CH, Franco L, Rinehart D, Valentine E, Gowda H, Ubhi BK, Tautenhahn R, Gieschen A, Fields MW, Patti GJ, Siuzdak G Analytical chemistry 25496351 Anal Chem 2015 Jan 20
Credentialing features: a platform to benchmark and optimize untargeted metabolomic methods. Mahieu NG, Huang X, Chen YJ, Patti GJ Analytical chemistry 25160088 Anal Chem 2014 Oct 7
Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging. O'Brien PJ, Lee M, Spilker ME, Zhang CC, Yan Z, Nichols TC, Li W, Johnson CH, Patti GJ, Siuzdak G Cancer & metabolism 24280026 Cancer Metab 2013 Jan 23
A roadmap for the XCMS family of software solutions in metabolomics. Mahieu NG, Genenbacher JL, Patti GJ Current opinion in chemical biology 26673825 Curr Opin Chem Biol 2016 Feb
Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells. Gelman SJ, Mahieu NG, Cho K, Llufrio EM, Wencewicz TA, Patti GJ Cancer & metabolism 26629338 Cancer Metab 2015
Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes. Leamy AK, Hasenour CM, Egnatchik RA, Trenary IA, Yao CH, Patti GJ, Shiota M, Young JD Biochimica et biophysica acta 27249207 Biochim Biophys Acta 2016 Sep
Trace Phosphate Improves ZIC-pHILIC Peak Shape, Sensitivity, and Coverage for Untargeted Metabolomics. Spalding JL, Naser FJ, Mahieu NG, Johnson SL, Patti GJ Journal of proteome research 30160483 J Proteome Res 2018 Oct 5
The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. Dougherty JD, Maloney SE, Wozniak DF, Rieger MA, Sonnenblick L, Coppola G, Mahieu NG, Zhang J, Cai J, Patti GJ, Abrahams BS, Geschwind DH, Heintz N The Journal of neuroscience : the official journal of the Society for Neuroscience 23407934 J Neurosci 2013 Feb 13
Metabolomic data streaming for biology-dependent data acquisition. Rinehart D, Johnson CH, Nguyen T, Ivanisevic J, Benton HP, Lloyd J, Arkin AP, Deutschbauer AM, Patti GJ, Siuzdak G Nature biotechnology 24911492 Nat Biotechnol 2014 Jun
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Inflammation triggers production of dimethylsphingosine from oligodendrocytes. Chen YJ, Hill S, Huang H, Taraboletti A, Cho K, Gallo R, Manchester M, Shriver LP, Patti GJ Neuroscience 25151189 Neuroscience 2014 Oct 24
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The isotridecanyl side chain of plusbacin-A3 is essential for the transglycosylase inhibition of peptidoglycan biosynthesis. Kim SJ, Singh M, Wohlrab A, Yu TY, Patti GJ, O'Connor RD, VanNieuwenhze M, Schaefer J Biochemistry 23421534 Biochemistry 2013 Mar 19
Warpgroup: increased precision of metabolomic data processing by consensus integration bound analysis. Mahieu NG, Spalding JL, Patti GJ Bioinformatics (Oxford, England) 26424859 Bioinformatics 2016 Jan 15
Defining the metabolome: size, flux, and regulation. Zamboni N, Saghatelian A, Patti GJ Molecular cell 26000853 Mol Cell 2015 May 21
Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts. Yao CH, Fowle-Grider R, Mahieu NG, Liu GY, Chen YJ, Wang R, Singh M, Potter GS, Gross RW, Schaefer J, Johnson SL, Patti GJ Cell chemical biology 27049668 Cell Chem Biol 2016 Apr 21
Discriminating precursors of common fragments for large-scale metabolite profiling by triple quadrupole mass spectrometry. Nikolskiy I, Siuzdak G, Patti GJ Bioinformatics (Oxford, England) 25691443 Bioinformatics 2015 Jun 15
Differential incorporation of glucose into biomass during Warburg metabolism. Chen YJ, Huang X, Mahieu NG, Cho K, Schaefer J, Patti GJ Biochemistry 25010499 Biochemistry 2014 Jul 29
Inaccurate quantitation of palmitate in metabolomics and isotope tracer studies due to plastics. Yao CH, Liu GY, Yang K, Gross RW, Patti GJ Metabolomics : Official journal of the Metabolomic Society 27721678 Metabolomics 2016 Sep
An untargeted metabolomic workflow to improve structural characterization of metabolites. Nikolskiy I, Mahieu NG, Chen YJ, Tautenhahn R, Patti GJ Analytical chemistry 23829391 Anal Chem 2013 Aug 20
A view from above: cloud plots to visualize global metabolomic data. Patti GJ, Tautenhahn R, Rinehart D, Cho K, Shriver LP, Manchester M, Nikolskiy I, Johnson CH, Mahieu NG, Siuzdak G Analytical chemistry 23206250 Anal Chem 2013 Jan 15
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Systems-Level Annotation of a Metabolomics Data Set Reduces 25 000 Features to Fewer than 1000 Unique Metabolites. Mahieu NG, Patti GJ Analytical chemistry 28914531 Anal Chem 2017 Oct 3
Two complementary reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome. Naser FJ, Mahieu NG, Wang L, Spalding JL, Johnson SL, Patti GJ Analytical and bioanalytical chemistry 29256075 Anal Bioanal Chem 2018 Feb
Studies of Secondary Melanoma on C57BL/6J Mouse Liver Using 1H NMR Metabolomics. Feng J, Isern NG, Burton SD, Hu JZ Metabolites 24958263 Metabolites 2013 Oct 31
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Structural analysis of N- and O-glycans using ZIC-HILIC/dialysis coupled to NMR detection. Qu Y, Feng J, Deng S, Cao L, Zhang Q, Zhao R, Zhang Z, Jiang Y, Zink EM, Baker SE, Lipton MS, Paša-Tolić L, Hu JZ, Wu S Fungal genetics and biology : FG & B 25117693 Fungal Genet Biol 2014 Nov
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Tandem mass spectrometry of novel ether-linked phospholipid analogs of anionic pulmonary surfactant phospholipids. Fickes R, Voelker DR, Berry KZ, Murphy RC Rapid communications in mass spectrometry : RCM 27689848 Rapid Commun Mass Spectrom 2016 Dec 30
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Tandem Mass Spectrometry in Combination with Product Ion Mobility for the Identification of Phospholipids. Berry KA, Barkley RM, Berry JJ, Hankin JA, Hoyes E, Brown JM, Murphy RC Analytical chemistry 27958700 Anal Chem 2017 Jan 3
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Mechanism of formation of the major estradiol product ions following collisional activation of the molecular anion in a tandem quadrupole mass spectrometer. Wooding KM, Barkley RM, Hankin JA, Johnson CA, Bradford AP, Santoro N, Murphy RC Journal of the American Society for Mass Spectrometry 23955001 J Am Soc Mass Spectrom 2013 Oct
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Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise. Seiler SE, Koves TR, Gooding JR, Wong KE, Stevens RD, Ilkayeva OR, Wittmann AH, DeBalsi KL, Davies MN, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB, Muoio DM Cell metabolism 26154055 Cell Metab 2015 Jul 7
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Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI. Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavía-Jiménez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I JCI insight 28768909 JCI Insight 2017 Aug 3
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Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT Journal of thrombosis and haemostasis : JTH 27629384 J Thromb Haemost 2016 Nov
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