Understudied Proteins

The implementation phase of the IDG program will focus on elucidating the function of understudied proteins from three protein families; non-olfactory GPCRs, ion channels, and protein kinases. This page lists protein targets that will be the initial focus of the implementation phase of the IDG program. These lists were generated using bibliometric measures coupled with a lack of R01 funding and were updated on October 2, 2018.

Kinases

PRKAG1, PRKAB1, ADCK2, ADCK5, ALPK3, ADCK4, ALPK2, BCKDK, CAMKV, CDKL3, CDKL4, CDKL1, CDKL2, CDK15, CDK17, CDK11B, CDK14, CDK18, CLK4, CDK10, CLK3, CSNK2A2, DGKH, DYRK3, DYRK1B, DYRK4, EEF2K, DYRK2, ERN2, FASTK, GK2, HIPK4, ITPKA, CSNK1G3, CSNK1G2, PRKACG, CSNK1G1, ITPK1, PSKH2, CAMK1D, TK2, PRKACB, PNCK, CAMK1G, CAMKK1, PSKH1, PHKA1, RPS6KC1, PRKCQ, LMTK3, MARK4, MAST3, LRRK1, MAP3K14, LTK, MAP3K10, MAST4, MAST2, MAPK15, MAPK4, MKNK2, CDC42BPG, CDC42BPB, NEK11, NEK5, NEK10, NIM1K, NEK4, NEK6, NRK, NEK7, SCYL1, NRBP2, PIK3C2G, PAK7, PANK3, PIK3C2B, PAK3, PAK6, SCYL3, PDIK1L, PIP4K2C, PIP5K1A, PLK5, PHKG1, PHKG2, PI4KA, PIP5K1B, PKMYT1, PKN3, PRPF4B, TP53RK, PRKRA, PRKY, PXK, RIOK1, RIOK3, RPS6KL1, SBK2, SCYL2, SBK3, SGK494, POMK, SGK223, SRPK3, STK32C, STK33, STK32B, STK40, STK17A, STK36, STK32A, STK38L, STKLD1, STK3, STK31, TESK2, TESK1, TBCK, TLK1, TPK1, TLK2, TSSK6, TSSK1B, TTBK2, TSSK4, TTBK1, TSSK3, UCK1, ULK4, UCK2, WNK2, VRK2, WEE2

Ion Channels

HTR3B, HTR3E, HTR3D, CHRNB2, HTR3C, CHRND, CHRNB1, CHRNA10, CHRNA2, CHRNA9, CHRNG, ASIC4, ASIC5, BEST4, CACNA2D1, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNA2D2, CACNG6, CACNA1F, CACNB4, CACNG1, CACNG5, CACNG3, CACNG7, CACNG4, CACNG8, CLCNKA, CLIC6, CLIC2, CLCA4, CLCC1, CLCA3P, CNGA4, CLCN6, CLIC5, CLCA2, CLIC3, CATSPER4, CATSPER2, FAM26F, FAM26D, FAM26E, FXYD3, FXYD7, FXYD6P3, GABRA6, GABRG3, GABRR3, GABRB1, GABRG1, GABRP, GABRA5, GABRR1, GPR89A, GLRA3, GLRA4, GLRB, GPR89A, GRID1, GRIK3, HCN3, KCND1, KCNK4, KCNK7, KCNS1, KCNS2, KCNIP1, KCNJ15, KCNMB4, KCNK16, ITPR2, KCNH6, KCNH7, KCNH8, KCNK12, KCNMB3, KCNA6, KCNG2, KCNN1, KCNAB2, KCNIP4, KCNC4, KCNG3, KCNH4, KCNS3, KCNAB3, KCNG4, KCNA7, KCNT1, KCNJ14, KCNJ18, KCNV1, LRRC52, LRRC55, LRRC38, PANX3, PANX2, PLLP, PKD1L2, PKD2L2, PKD1L3, SLC26A1, SCN3B, SCN7A, SCNN1D, SCN2B, SCNN1B, TMC5, TMC7, TMEM38B, TMC3, TMC4, TTYH2, TTYH1

Non-Olfactory GCPRs

HTR1E, HTR5A, ADGRD1, ADGRE2, ADGRF5, ADGRG4, ADGRG7, ADGRB2, ADGRF2, ADGRF4, CHRM5, ADGRF1, ADGRG3, ADGRG5, ADGRD2, ADGRE1, ADGRE3, ADGRF3, ADGRG2, ADGRB3, ADGRA1, ADGRE4P, ADGRL3, CELSR2, GPR137, FZD10, GPR32P1, GALR3, GPR139, GPR149, GPR171, GPR174, GPR142, GPR151, GPR156, GPRC5D, GPR153, GPR33, GPR25, GPR45, GPR75, GPR88, GNRHR2, GPR150, GPR18, GPR62, GPR82, GPR87, GPR101, GPR173, GPRC5C, GPR32, GPR63, GPRC5B, GPR12, GPR135, GPR141, GPR146, GPR152, GPR157, GPR160, GPR42, GPR52, GPR143, GPR162, GPR26, GPR21, GPR61, GPR20, GPR27, GPR31, GPR34, GPR39, GPR4, GPR6, GPR78, GPR85, GPR19, GPR22, HCAR1, HCAR3, MAS1L, LPAR6, MRGPRX4, MRGPRG, MRGPRX2, MTNR1A, MRGPRE, MRGPRX3, NPBWR1, NPBWR2, NPY6R, NPY2R, NPY5R, OPN1MW2, OXGR1, P2RY10, OXER1, RRH, P2RY11, PROKR1, QRFPR, GPRC5A, RXFP3, RXFP4, S1PR4, SSTR4, SUCNR1, TAS2R31, TAS2R14, TAAR3, TAS2R10, TAS2R41, TAS2R43, TAS2R50, TAAR2, TAAR8, TAS2R19, TAS2R7, TAS2R9, TAS2R13, TAS2R20, TAS2R40, TAS2R60, TAS2R3, TAS2R4, TAS2R5, TAS2R16, TAS2R8, TAAR9, TAS2R39, TAS2R1, TAS2R30, TAS2R42, TAS2R46, TPRA1, AVPR1B, VN1R17P, VN1R3, VN1R5, VN1R1, VN1R4, VN1R2

This page last reviewed on October 3, 2018