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Understudied Proteins

The implementation phase of the IDG program will focus on elucidating the function of understudied proteins from three protein families; non-olfactory GPCRs, ion channels, and protein kinases. This page lists protein targets that have been identified by the IDG program that are currently understudied. This page was last updated on June 11, 2019.

Gene Protein Name
ADCK1 Uncharacterized aarF domain-containing protein kinase 1
ADCK2 Uncharacterized aarF domain-containing protein kinase 2
ADCK5 Uncharacterized aarF domain-containing protein kinase 5
ALPK2 Alpha-protein kinase 2
ALPK3 Alpha-protein kinase 3
BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
BRSK1 Serine/threonine-protein kinase BRSK1
CAMK1D Calcium/calmodulin-dependent protein kinase type 1D
CAMK1G Calcium/calmodulin-dependent protein kinase type 1G
CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1
CAMKV CaM kinase-like vesicle-associated protein
CDC42BPA Serine/threonine-protein kinase MRCK alpha
CDC42BPB Serine/threonine-protein kinase MRCK beta
CDC42BPG Serine/threonine-protein kinase MRCK gamma
CDK10 Cyclin-dependent kinase 10
CDK11A Cyclin-dependent kinase 11A
CDK11B Cyclin-dependent kinase 11B
CDK12 Cyclin-dependent kinase 12
CDK13 Cyclin-dependent kinase 13
CDK14 Cyclin-dependent kinase 14
CDK15 Cyclin-dependent kinase 15
CDK16 Cyclin-dependent kinase 16
CDK17 Cyclin-dependent kinase 17
CDK18 Cyclin-dependent kinase 18
CDK19 Cyclin-dependent kinase 19
CDK20 Cyclin-dependent kinase 20
CDKL1 Cyclin-dependent kinase-like 1
CDKL2 Cyclin-dependent kinase-like 2
CDKL3 Cyclin-dependent kinase-like 3
CDKL4 Cyclin-dependent kinase-like 4
CLK3 Dual specificity protein kinase CLK3
CLK4 Dual specificity protein kinase CLK4
COQ8A Atypical kinase COQ8A, mitochondrial
COQ8B Atypical kinase COQ8B, mitochondrial
CSNK1A1L Casein kinase I isoform alpha-like
CSNK1G1 Casein kinase I isoform gamma-1
CSNK1G2 Casein kinase I isoform gamma-2
CSNK1G3 Casein kinase I isoform gamma-3
CSNK2A3 Casein kinase II subunit alpha 3
DCLK3 Serine/threonine-protein kinase DCLK3
DSTYK Dual serine/threonine and tyrosine protein kinase
DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B
DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK3 Dual specificity tyrosine-phosphorylation-regulated kinase 3
DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4
EEF2K Eukaryotic elongation factor 2 kinase
ERN2 Serine/threonine-protein kinase/endoribonuclease IRE2
HIPK1 Homeodomain-interacting protein kinase 1
HIPK3 Homeodomain-interacting protein kinase 3
HIPK4 Homeodomain-interacting protein kinase 4
ICK Serine/threonine-protein kinase ICK
LMTK2 Serine/threonine-protein kinase LMTK2
LMTK3 Serine/threonine-protein kinase LMTK3
LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1
LTK Leukocyte tyrosine kinase receptor
MAP3K10 Mitogen-activated protein kinase kinase kinase 10
MAP3K14 Mitogen-activated protein kinase kinase kinase 14
MAP3K15 Mitogen-activated protein kinase kinase kinase 15
MAP3K21 Mitogen-activated protein kinase kinase kinase 21
MAPK15 Mitogen-activated protein kinase 15
MAPK4 Mitogen-activated protein kinase 4
MARK1 Serine/threonine-protein kinase MARK1
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST2 Microtubule-associated serine/threonine-protein kinase 2
MAST3 Microtubule-associated serine/threonine-protein kinase 3
MAST4 Microtubule-associated serine/threonine-protein kinase 4
MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2
NEK1 Serine/threonine-protein kinase Nek1
NEK10 Serine/threonine-protein kinase Nek10
NEK11 Serine/threonine-protein kinase Nek11
NEK3 Serine/threonine-protein kinase Nek3
NEK4 Serine/threonine-protein kinase Nek4
NEK5 Serine/threonine-protein kinase Nek5
NEK6 Serine/threonine-protein kinase Nek6
NEK7 Serine/threonine-protein kinase Nek7
NEK9 Serine/threonine-protein kinase Nek9
NIM1K Serine/threonine-protein kinase NIM1
NRBP2 Nuclear receptor-binding protein 2
NRK Nik-related protein kinase
NUAK2 NUAK family SNF1-like kinase 2
PAK3 Serine/threonine-protein kinase PAK 3
PAK5 Serine/threonine-protein kinase PAK 5
PAK6 Serine/threonine-protein kinase PAK 6
PAN3 PAN2-PAN3 deadenylation complex subunit PAN3
PDIK1L Serine/threonine-protein kinase PDIK1L
PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
PI4KA Phosphatidylinositol 4-kinase alpha
PIK3C2B Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1B Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
PKN3 Serine/threonine-protein kinase N3
PNCK Calcium/calmodulin-dependent protein kinase type 1B
POMK Protein O-mannose kinase
PRKACB cAMP-dependent protein kinase catalytic subunit beta
PRKACG cAMP-dependent protein kinase catalytic subunit gamma
PRPF4B Serine/threonine-protein kinase PRP4 homolog
PSKH1 Serine/threonine-protein kinase H1
PSKH2 Serine/threonine-protein kinase H2
PXK PX domain-containing protein kinase-like protein
RIOK1 Serine/threonine-protein kinase RIO1
RIOK2 Serine/threonine-protein kinase RIO2
RIOK3 Serine/threonine-protein kinase RIO3
RPS6KC1 Ribosomal protein S6 kinase delta-1
RPS6KL1 Ribosomal protein S6 kinase-like 1
SBK2 Serine/threonine-protein kinase SBK2
SBK3 Uncharacterized serine/threonine-protein kinase SBK3
SCYL2 SCY1-like protein 2
SCYL3 Protein-associating with the carboxyl-terminal domain of ezrin
SGK494 Uncharacterized serine/threonine-protein kinase SgK494
SRPK3 SRSF protein kinase 3
STK17A Serine/threonine-protein kinase 17A
STK17B Serine/threonine-protein kinase 17B
STK19 Serine/threonine-protein kinase 19
STK3 Serine/threonine-protein kinase 3
STK31 Serine/threonine-protein kinase 31
STK32A Serine/threonine-protein kinase 32A
STK32B Serine/threonine-protein kinase 32B
STK32C Serine/threonine-protein kinase 32C
STK33 Serine/threonine-protein kinase 33
STK36 Serine/threonine-protein kinase 36
STK38L Serine/threonine-protein kinase 38-like
STK40 Serine/threonine-protein kinase 40
STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1
TAOK1 Serine/threonine-protein kinase TAO1
TAOK2 Serine/threonine-protein kinase TAO2
TBCK TBC domain-containing protein kinase-like protein
TESK1 Dual specificity testis-specific protein kinase 1
TESK2 Dual specificity testis-specific protein kinase 2
TLK1 Serine/threonine-protein kinase tousled-like 1
TLK2 Serine/threonine-protein kinase tousled-like 2
TP53RK EKC/KEOPS complex subunit TP53RK
TSSK1B Testis-specific serine/threonine-protein kinase 1
TSSK2 Testis-specific serine/threonine-protein kinase 2
TSSK3 Testis-specific serine/threonine-protein kinase 3
TSSK4 Testis-specific serine/threonine-protein kinase 4
TSSK6 Testis-specific serine/threonine-protein kinase 6
TTBK1 Tau-tubulin kinase 1
TTBK2 Tau-tubulin kinase 2
ULK4 Serine/threonine-protein kinase ULK4
VRK2 Serine/threonine-protein kinase VRK2
VRK3 Inactive serine/threonine-protein kinase VRK3
WEE2 Wee1-like protein kinase 2
WNK2 Serine/threonine-protein kinase WNK2
WNK3 Serine/threo+B1:C151nine-protein kinase WNK3
BRSK2 Serine/threonine-protein kinase BRSK2

Gene Protein Name
ASIC4 Acid-sensing ion channel 4
BEST4 Bestrophin-4
CACNA2D2 Voltage-dependent calcium channel subunit alpha-2/delta-2
CACNA2D3 Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D4 Voltage-dependent calcium channel subunit alpha-2/delta-4
CACNG1 Voltage-dependent calcium channel gamma-1 subunit
CACNG3 Voltage-dependent calcium channel gamma-3 subunit
CACNG4 Voltage-dependent calcium channel gamma-4 subunit
CACNG5 Voltage-dependent calcium channel gamma-5 subunit
CACNG6 Voltage-dependent calcium channel gamma-6 subunit
CACNG7 Voltage-dependent calcium channel gamma-7 subunit
CACNG8 Voltage-dependent calcium channel gamma-8 subunit
CALHM4 Calcium homeostasis modulator protein 4
CALHM5 Calcium homeostasis modulator protein 5
CALHM6 Calcium homeostasis modulator protein 6
CATSPER2 Cation channel sperm-associated protein 2
CHRNA10 Neuronal acetylcholine receptor subunit alpha-10
CHRNB1 Acetylcholine receptor subunit beta
CLCA4 Calcium-activated chloride channel regulator 4
CLCC1 Chloride channel CLIC-like protein 1
CLCN6 Chloride transport protein 6
CLIC6 Chloride intracellular channel protein 6
GABRP Gamma-aminobutyric acid receptor subunit pi
GPR89A Golgi pH regulator A
GPR89B Golgi pH regulator B
GRID1 Glutamate receptor ionotropic, delta-1
KCNA6 Potassium voltage-gated channel subfamily A member 6
KCNA7 Potassium voltage-gated channel subfamily A member 7
KCNAB2 Voltage-gated potassium channel subunit beta-2
KCNAB3 Voltage-gated potassium channel subunit beta-3
KCND1 Potassium voltage-gated channel subfamily D member 1
KCNG2 Potassium voltage-gated channel subfamily G member 2
KCNG3 Potassium voltage-gated channel subfamily G member 3
KCNG4 Potassium voltage-gated channel subfamily G member 4
KCNH4 Potassium voltage-gated channel subfamily H member 4
KCNH6 Potassium voltage-gated channel subfamily H member 6
KCNH8 Potassium voltage-gated channel subfamily H member 8
KCNJ15 ATP-sensitive inward rectifier potassium channel 15
KCNJ18 Inward rectifier potassium channel 18
KCNK12 Potassium channel subfamily K member 12
KCNK7 Potassium channel subfamily K member 7
KCNMB3 Calcium-activated potassium channel subunit beta-3
KCNN1 Small conductance calcium-activated potassium channel protein 1
KCNS1 Potassium voltage-gated channel subfamily S member 1
KCNS2 Potassium voltage-gated channel subfamily S member 2
LRRC38 Leucine-rich repeat-containing protein 38
LRRC55 Leucine-rich repeat-containing protein 55
PKD1L2 Polycystic kidney disease protein 1-like 2
PKD1L3 Polycystic kidney disease protein 1-like 3
PKD2L2 Polycystic kidney disease 2-like 2 protein
PLLP Plasmolipin
SCN7A Sodium channel protein type 7 subunit alpha
SLC26A1 Sulfate anion transporter 1
TMC3 Transmembrane channel-like protein 3
TMC4 Transmembrane channel-like protein 4
TMC5 Transmembrane channel-like protein 5
TMC7 Transmembrane channel-like protein 7
TMEM38B Trimeric intracellular cation channel type B
TMEM63A CSC1-like protein 1
TMEM63B CSC1-like protein 2
TTYH1 Protein tweety homolog 1
TTYH2 Protein tweety homolog 2

Gene Protein Name
ADGRA1 Adhesion G protein-coupled receptor A1
ADGRA3 Adhesion G protein-coupled receptor A3
ADGRB2 Adhesion G protein-coupled receptor B2
ADGRB3 Adhesion G protein-coupled receptor B3
ADGRD1 Adhesion G-protein coupled receptor D1
ADGRD2 Adhesion G-protein coupled receptor D2
ADGRE1 Adhesion G protein-coupled receptor E1
ADGRE3 Adhesion G protein-coupled receptor E3
ADGRF1 Adhesion G-protein coupled receptor F1
ADGRF2 Adhesion G-protein coupled receptor F2
ADGRF3 Adhesion G-protein coupled receptor F3
ADGRF4 Adhesion G protein-coupled receptor F4
ADGRF5 Adhesion G protein-coupled receptor F5
ADGRG2 Adhesion G-protein coupled receptor G2
ADGRG3 Adhesion G protein-coupled receptor G3
ADGRG4 Adhesion G-protein coupled receptor G4
ADGRG5 Adhesion G-protein coupled receptor G5
ADGRG7 Adhesion G-protein coupled receptor G7
FZD10 Frizzled-10
GNRHR2 Putative gonadotropin-releasing hormone II receptor
GPR101 Probable G-protein coupled receptor 101
GPR12 G-protein coupled receptor 12
GPR135 G-protein coupled receptor 135
GPR137 Integral membrane protein GPR137
GPR139 Probable G-protein coupled receptor 139
GPR141 Probable G-protein coupled receptor 141
GPR142 Probable G-protein coupled receptor 142
GPR146 Probable G-protein coupled receptor 146
GPR149 Probable G-protein coupled receptor 149
GPR150 Probable G-protein coupled receptor 150
GPR151 Probable G-protein coupled receptor 151
GPR152 Probable G-protein coupled receptor 152
GPR153 Probable G-protein coupled receptor 153
GPR156 Probable G-protein coupled receptor 156
GPR157 G-protein coupled receptor 157
GPR160 Probable G-protein coupled receptor 160
GPR162 Probable G-protein coupled receptor 162
GPR171 Probable G-protein coupled receptor 171
GPR173 Probable G-protein coupled receptor 173
GPR174 Probable G-protein coupled receptor 174
GPR18 N-arachidonyl glycine receptor
GPR19 Probable G-protein coupled receptor 19
GPR20 G-protein coupled receptor 20
GPR21 Probable G-protein coupled receptor 21
GPR22 G-protein coupled receptor 22
GPR25 Probable G-protein coupled receptor 25
GPR26 G-protein coupled receptor 26
GPR27 Probable G-protein coupled receptor 27
GPR3 G-protein coupled receptor 3
GPR31 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
GPR32 Probable G-protein coupled receptor 32
GPR34 Probable G-protein coupled receptor 34
GPR37L1 G-protein coupled receptor 37-like 1
GPR4 G-protein coupled receptor 4
GPR45 Probable G-protein coupled receptor 45
GPR52 G-protein coupled receptor 52
GPR6 G-protein coupled receptor 6
GPR61 G-protein coupled receptor 61
GPR62 G-protein coupled receptor 62
GPR63 Probable G-protein coupled receptor 63
GPR65 Psychosine receptor
GPR68 Ovarian cancer G-protein coupled receptor 1
GPR75 Probable G-protein coupled receptor 75
GPR78 G-protein coupled receptor 78
GPR82 Probable G-protein coupled receptor 82
GPR85 Probable G-protein coupled receptor 85
GPR87 G-protein coupled receptor 87
GPR88 Probable G-protein coupled receptor 88
GPRC5A Retinoic acid-induced protein 3
GPRC5B G-protein coupled receptor family C group 5 member B
GPRC5C G-protein coupled receptor family C group 5 member C
GPRC5D G-protein coupled receptor family C group 5 member D
HCAR1 Hydroxycarboxylic acid receptor 1
HCAR3 Hydroxycarboxylic acid receptor 3
LPAR6 Lysophosphatidic acid receptor 6
MRGPRE Mas-related G-protein coupled receptor member E
MRGPRF Mas-related G-protein coupled receptor member F
MRGPRG Mas-related G-protein coupled receptor member G
MRGPRX1 Mas-related G-protein coupled receptor member X1
MRGPRX2 Mas-related G-protein coupled receptor member X2
MRGPRX3 Mas-related G-protein coupled receptor member X3
MRGPRX4 Mas-related G-protein coupled receptor member X4
NPBWR1 Neuropeptides B/W receptor type 1
NPBWR2 Neuropeptides B/W receptor type 2
OXER1 Oxoeicosanoid receptor 1
OXGR1 2-oxoglutarate receptor 1
P2RY10 Putative P2Y purinoceptor 10
PROKR1 Prokineticin receptor 1
QRFPR Pyroglutamylated RF-amide peptide receptor
RXFP4 Relaxin-3 receptor 2
TAAR2 Trace amine-associated receptor 2
TAAR3P Putative trace amine-associated receptor 3
TAAR8 Trace amine-associated receptor 8
TAAR9 Trace amine-associated receptor 9
TAS2R1 Taste receptor type 2 member 1
TAS2R10 Taste receptor type 2 member 10
TAS2R13 Taste receptor type 2 member 13
TAS2R14 Taste receptor type 2 member 14
TAS2R16 Taste receptor type 2 member 16
TAS2R19 Taste receptor type 2 member 19
TAS2R20 Taste receptor type 2 member 20
TAS2R3 Taste receptor type 2 member 3
TAS2R30 Taste receptor type 2 member 30
TAS2R31 Taste receptor type 2 member 31
TAS2R39 Taste receptor type 2 member 39
TAS2R4 Taste receptor type 2 member 4
TAS2R40 Taste receptor type 2 member 40
TAS2R41 Taste receptor type 2 member 41
TAS2R42 Taste receptor type 2 member 42
TAS2R43 Taste receptor type 2 member 43
TAS2R46 Taste receptor type 2 member 46
TAS2R5 Taste receptor type 2 member 5
TAS2R50 Taste receptor type 2 member 50
TAS2R60 Taste receptor type 2 member 60
TAS2R7 Taste receptor type 2 member 7
TAS2R8 Taste receptor type 2 member 8
TAS2R9 Taste receptor type 2 member 9

This page last reviewed on September 13, 2023