Illuminating the Druggable Genome (IDG)
Illuminating the Druggable Genome (IDG)
Understudied Proteins
The implementation phase of the IDG program will focus on elucidating the function of understudied proteins from three protein families; non-olfactory GPCRs, ion channels, and protein kinases. This page lists protein targets that have been identified by the IDG program that are currently understudied. This page was last updated on June 11, 2019.
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Eligible Kinases
| Gene | Protein Name |
|---|---|
| ADCK1 | Uncharacterized aarF domain-containing protein kinase 1 |
| ADCK2 | Uncharacterized aarF domain-containing protein kinase 2 |
| ADCK5 | Uncharacterized aarF domain-containing protein kinase 5 |
| ALPK2 | Alpha-protein kinase 2 |
| ALPK3 | Alpha-protein kinase 3 |
| BCKDK | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial |
| BRSK1 | Serine/threonine-protein kinase BRSK1 |
| CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D |
| CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G |
| CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1 |
| CAMKV | CaM kinase-like vesicle-associated protein |
| CDC42BPA | Serine/threonine-protein kinase MRCK alpha |
| CDC42BPB | Serine/threonine-protein kinase MRCK beta |
| CDC42BPG | Serine/threonine-protein kinase MRCK gamma |
| CDK10 | Cyclin-dependent kinase 10 |
| CDK11A | Cyclin-dependent kinase 11A |
| CDK11B | Cyclin-dependent kinase 11B |
| CDK12 | Cyclin-dependent kinase 12 |
| CDK13 | Cyclin-dependent kinase 13 |
| CDK14 | Cyclin-dependent kinase 14 |
| CDK15 | Cyclin-dependent kinase 15 |
| CDK16 | Cyclin-dependent kinase 16 |
| CDK17 | Cyclin-dependent kinase 17 |
| CDK18 | Cyclin-dependent kinase 18 |
| CDK19 | Cyclin-dependent kinase 19 |
| CDK20 | Cyclin-dependent kinase 20 |
| CDKL1 | Cyclin-dependent kinase-like 1 |
| CDKL2 | Cyclin-dependent kinase-like 2 |
| CDKL3 | Cyclin-dependent kinase-like 3 |
| CDKL4 | Cyclin-dependent kinase-like 4 |
| CLK3 | Dual specificity protein kinase CLK3 |
| CLK4 | Dual specificity protein kinase CLK4 |
| COQ8A | Atypical kinase COQ8A, mitochondrial |
| COQ8B | Atypical kinase COQ8B, mitochondrial |
| CSNK1A1L | Casein kinase I isoform alpha-like |
| CSNK1G1 | Casein kinase I isoform gamma-1 |
| CSNK1G2 | Casein kinase I isoform gamma-2 |
| CSNK1G3 | Casein kinase I isoform gamma-3 |
| CSNK2A3 | Casein kinase II subunit alpha 3 |
| DCLK3 | Serine/threonine-protein kinase DCLK3 |
| DSTYK | Dual serine/threonine and tyrosine protein kinase |
| DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
| DYRK3 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| DYRK4 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
| EEF2K | Eukaryotic elongation factor 2 kinase |
| ERN2 | Serine/threonine-protein kinase/endoribonuclease IRE2 |
| HIPK1 | Homeodomain-interacting protein kinase 1 |
| HIPK3 | Homeodomain-interacting protein kinase 3 |
| HIPK4 | Homeodomain-interacting protein kinase 4 |
| ICK | Serine/threonine-protein kinase ICK |
| LMTK2 | Serine/threonine-protein kinase LMTK2 |
| LMTK3 | Serine/threonine-protein kinase LMTK3 |
| LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 |
| LTK | Leukocyte tyrosine kinase receptor |
| MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 |
| MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 |
| MAP3K15 | Mitogen-activated protein kinase kinase kinase 15 |
| MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 |
| MAPK15 | Mitogen-activated protein kinase 15 |
| MAPK4 | Mitogen-activated protein kinase 4 |
| MARK1 | Serine/threonine-protein kinase MARK1 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 |
| MAST2 | Microtubule-associated serine/threonine-protein kinase 2 |
| MAST3 | Microtubule-associated serine/threonine-protein kinase 3 |
| MAST4 | Microtubule-associated serine/threonine-protein kinase 4 |
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 |
| NEK1 | Serine/threonine-protein kinase Nek1 |
| NEK10 | Serine/threonine-protein kinase Nek10 |
| NEK11 | Serine/threonine-protein kinase Nek11 |
| NEK3 | Serine/threonine-protein kinase Nek3 |
| NEK4 | Serine/threonine-protein kinase Nek4 |
| NEK5 | Serine/threonine-protein kinase Nek5 |
| NEK6 | Serine/threonine-protein kinase Nek6 |
| NEK7 | Serine/threonine-protein kinase Nek7 |
| NEK9 | Serine/threonine-protein kinase Nek9 |
| NIM1K | Serine/threonine-protein kinase NIM1 |
| NRBP2 | Nuclear receptor-binding protein 2 |
| NRK | Nik-related protein kinase |
| NUAK2 | NUAK family SNF1-like kinase 2 |
| PAK3 | Serine/threonine-protein kinase PAK 3 |
| PAK5 | Serine/threonine-protein kinase PAK 5 |
| PAK6 | Serine/threonine-protein kinase PAK 6 |
| PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3 |
| PDIK1L | Serine/threonine-protein kinase PDIK1L |
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
| PI4KA | Phosphatidylinositol 4-kinase alpha |
| PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta |
| PIK3C2G | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma |
| PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha |
| PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta |
| PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma |
| PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
| PKN3 | Serine/threonine-protein kinase N3 |
| PNCK | Calcium/calmodulin-dependent protein kinase type 1B |
| POMK | Protein O-mannose kinase |
| PRKACB | cAMP-dependent protein kinase catalytic subunit beta |
| PRKACG | cAMP-dependent protein kinase catalytic subunit gamma |
| PRPF4B | Serine/threonine-protein kinase PRP4 homolog |
| PSKH1 | Serine/threonine-protein kinase H1 |
| PSKH2 | Serine/threonine-protein kinase H2 |
| PXK | PX domain-containing protein kinase-like protein |
| RIOK1 | Serine/threonine-protein kinase RIO1 |
| RIOK2 | Serine/threonine-protein kinase RIO2 |
| RIOK3 | Serine/threonine-protein kinase RIO3 |
| RPS6KC1 | Ribosomal protein S6 kinase delta-1 |
| RPS6KL1 | Ribosomal protein S6 kinase-like 1 |
| SBK2 | Serine/threonine-protein kinase SBK2 |
| SBK3 | Uncharacterized serine/threonine-protein kinase SBK3 |
| SCYL2 | SCY1-like protein 2 |
| SCYL3 | Protein-associating with the carboxyl-terminal domain of ezrin |
| SGK494 | Uncharacterized serine/threonine-protein kinase SgK494 |
| SRPK3 | SRSF protein kinase 3 |
| STK17A | Serine/threonine-protein kinase 17A |
| STK17B | Serine/threonine-protein kinase 17B |
| STK19 | Serine/threonine-protein kinase 19 |
| STK3 | Serine/threonine-protein kinase 3 |
| STK31 | Serine/threonine-protein kinase 31 |
| STK32A | Serine/threonine-protein kinase 32A |
| STK32B | Serine/threonine-protein kinase 32B |
| STK32C | Serine/threonine-protein kinase 32C |
| STK33 | Serine/threonine-protein kinase 33 |
| STK36 | Serine/threonine-protein kinase 36 |
| STK38L | Serine/threonine-protein kinase 38-like |
| STK40 | Serine/threonine-protein kinase 40 |
| STKLD1 | Serine/threonine kinase-like domain-containing protein STKLD1 |
| TAOK1 | Serine/threonine-protein kinase TAO1 |
| TAOK2 | Serine/threonine-protein kinase TAO2 |
| TBCK | TBC domain-containing protein kinase-like protein |
| TESK1 | Dual specificity testis-specific protein kinase 1 |
| TESK2 | Dual specificity testis-specific protein kinase 2 |
| TLK1 | Serine/threonine-protein kinase tousled-like 1 |
| TLK2 | Serine/threonine-protein kinase tousled-like 2 |
| TP53RK | EKC/KEOPS complex subunit TP53RK |
| TSSK1B | Testis-specific serine/threonine-protein kinase 1 |
| TSSK2 | Testis-specific serine/threonine-protein kinase 2 |
| TSSK3 | Testis-specific serine/threonine-protein kinase 3 |
| TSSK4 | Testis-specific serine/threonine-protein kinase 4 |
| TSSK6 | Testis-specific serine/threonine-protein kinase 6 |
| TTBK1 | Tau-tubulin kinase 1 |
| TTBK2 | Tau-tubulin kinase 2 |
| ULK4 | Serine/threonine-protein kinase ULK4 |
| VRK2 | Serine/threonine-protein kinase VRK2 |
| VRK3 | Inactive serine/threonine-protein kinase VRK3 |
| WEE2 | Wee1-like protein kinase 2 |
| WNK2 | Serine/threonine-protein kinase WNK2 |
| WNK3 | Serine/threo+B1:C151nine-protein kinase WNK3 |
| BRSK2 | Serine/threonine-protein kinase BRSK2 |
Eligible Ion Channels
| Gene | Protein Name |
|---|---|
| ASIC4 | Acid-sensing ion channel 4 |
| BEST4 | Bestrophin-4 |
| CACNA2D2 | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
| CACNA2D3 | Voltage-dependent calcium channel subunit alpha-2/delta-3 |
| CACNA2D4 | Voltage-dependent calcium channel subunit alpha-2/delta-4 |
| CACNG1 | Voltage-dependent calcium channel gamma-1 subunit |
| CACNG3 | Voltage-dependent calcium channel gamma-3 subunit |
| CACNG4 | Voltage-dependent calcium channel gamma-4 subunit |
| CACNG5 | Voltage-dependent calcium channel gamma-5 subunit |
| CACNG6 | Voltage-dependent calcium channel gamma-6 subunit |
| CACNG7 | Voltage-dependent calcium channel gamma-7 subunit |
| CACNG8 | Voltage-dependent calcium channel gamma-8 subunit |
| CALHM4 | Calcium homeostasis modulator protein 4 |
| CALHM5 | Calcium homeostasis modulator protein 5 |
| CALHM6 | Calcium homeostasis modulator protein 6 |
| CATSPER2 | Cation channel sperm-associated protein 2 |
| CHRNA10 | Neuronal acetylcholine receptor subunit alpha-10 |
| CHRNB1 | Acetylcholine receptor subunit beta |
| CLCA4 | Calcium-activated chloride channel regulator 4 |
| CLCC1 | Chloride channel CLIC-like protein 1 |
| CLCN6 | Chloride transport protein 6 |
| CLIC6 | Chloride intracellular channel protein 6 |
| GABRP | Gamma-aminobutyric acid receptor subunit pi |
| GPR89A | Golgi pH regulator A |
| GPR89B | Golgi pH regulator B |
| GRID1 | Glutamate receptor ionotropic, delta-1 |
| KCNA6 | Potassium voltage-gated channel subfamily A member 6 |
| KCNA7 | Potassium voltage-gated channel subfamily A member 7 |
| KCNAB2 | Voltage-gated potassium channel subunit beta-2 |
| KCNAB3 | Voltage-gated potassium channel subunit beta-3 |
| KCND1 | Potassium voltage-gated channel subfamily D member 1 |
| KCNG2 | Potassium voltage-gated channel subfamily G member 2 |
| KCNG3 | Potassium voltage-gated channel subfamily G member 3 |
| KCNG4 | Potassium voltage-gated channel subfamily G member 4 |
| KCNH4 | Potassium voltage-gated channel subfamily H member 4 |
| KCNH6 | Potassium voltage-gated channel subfamily H member 6 |
| KCNH8 | Potassium voltage-gated channel subfamily H member 8 |
| KCNJ15 | ATP-sensitive inward rectifier potassium channel 15 |
| KCNJ18 | Inward rectifier potassium channel 18 |
| KCNK12 | Potassium channel subfamily K member 12 |
| KCNK7 | Potassium channel subfamily K member 7 |
| KCNMB3 | Calcium-activated potassium channel subunit beta-3 |
| KCNN1 | Small conductance calcium-activated potassium channel protein 1 |
| KCNS1 | Potassium voltage-gated channel subfamily S member 1 |
| KCNS2 | Potassium voltage-gated channel subfamily S member 2 |
| LRRC38 | Leucine-rich repeat-containing protein 38 |
| LRRC55 | Leucine-rich repeat-containing protein 55 |
| PKD1L2 | Polycystic kidney disease protein 1-like 2 |
| PKD1L3 | Polycystic kidney disease protein 1-like 3 |
| PKD2L2 | Polycystic kidney disease 2-like 2 protein |
| PLLP | Plasmolipin |
| SCN7A | Sodium channel protein type 7 subunit alpha |
| SLC26A1 | Sulfate anion transporter 1 |
| TMC3 | Transmembrane channel-like protein 3 |
| TMC4 | Transmembrane channel-like protein 4 |
| TMC5 | Transmembrane channel-like protein 5 |
| TMC7 | Transmembrane channel-like protein 7 |
| TMEM38B | Trimeric intracellular cation channel type B |
| TMEM63A | CSC1-like protein 1 |
| TMEM63B | CSC1-like protein 2 |
| TTYH1 | Protein tweety homolog 1 |
| TTYH2 | Protein tweety homolog 2 |
Eligible GPCRs
| Gene | Protein Name |
|---|---|
| ADGRA1 | Adhesion G protein-coupled receptor A1 |
| ADGRA3 | Adhesion G protein-coupled receptor A3 |
| ADGRB2 | Adhesion G protein-coupled receptor B2 |
| ADGRB3 | Adhesion G protein-coupled receptor B3 |
| ADGRD1 | Adhesion G-protein coupled receptor D1 |
| ADGRD2 | Adhesion G-protein coupled receptor D2 |
| ADGRE1 | Adhesion G protein-coupled receptor E1 |
| ADGRE3 | Adhesion G protein-coupled receptor E3 |
| ADGRF1 | Adhesion G-protein coupled receptor F1 |
| ADGRF2 | Adhesion G-protein coupled receptor F2 |
| ADGRF3 | Adhesion G-protein coupled receptor F3 |
| ADGRF4 | Adhesion G protein-coupled receptor F4 |
| ADGRF5 | Adhesion G protein-coupled receptor F5 |
| ADGRG2 | Adhesion G-protein coupled receptor G2 |
| ADGRG3 | Adhesion G protein-coupled receptor G3 |
| ADGRG4 | Adhesion G-protein coupled receptor G4 |
| ADGRG5 | Adhesion G-protein coupled receptor G5 |
| ADGRG7 | Adhesion G-protein coupled receptor G7 |
| FZD10 | Frizzled-10 |
| GNRHR2 | Putative gonadotropin-releasing hormone II receptor |
| GPR101 | Probable G-protein coupled receptor 101 |
| GPR12 | G-protein coupled receptor 12 |
| GPR135 | G-protein coupled receptor 135 |
| GPR137 | Integral membrane protein GPR137 |
| GPR139 | Probable G-protein coupled receptor 139 |
| GPR141 | Probable G-protein coupled receptor 141 |
| GPR142 | Probable G-protein coupled receptor 142 |
| GPR146 | Probable G-protein coupled receptor 146 |
| GPR149 | Probable G-protein coupled receptor 149 |
| GPR150 | Probable G-protein coupled receptor 150 |
| GPR151 | Probable G-protein coupled receptor 151 |
| GPR152 | Probable G-protein coupled receptor 152 |
| GPR153 | Probable G-protein coupled receptor 153 |
| GPR156 | Probable G-protein coupled receptor 156 |
| GPR157 | G-protein coupled receptor 157 |
| GPR160 | Probable G-protein coupled receptor 160 |
| GPR162 | Probable G-protein coupled receptor 162 |
| GPR171 | Probable G-protein coupled receptor 171 |
| GPR173 | Probable G-protein coupled receptor 173 |
| GPR174 | Probable G-protein coupled receptor 174 |
| GPR18 | N-arachidonyl glycine receptor |
| GPR19 | Probable G-protein coupled receptor 19 |
| GPR20 | G-protein coupled receptor 20 |
| GPR21 | Probable G-protein coupled receptor 21 |
| GPR22 | G-protein coupled receptor 22 |
| GPR25 | Probable G-protein coupled receptor 25 |
| GPR26 | G-protein coupled receptor 26 |
| GPR27 | Probable G-protein coupled receptor 27 |
| GPR3 | G-protein coupled receptor 3 |
| GPR31 | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor |
| GPR32 | Probable G-protein coupled receptor 32 |
| GPR34 | Probable G-protein coupled receptor 34 |
| GPR37L1 | G-protein coupled receptor 37-like 1 |
| GPR4 | G-protein coupled receptor 4 |
| GPR45 | Probable G-protein coupled receptor 45 |
| GPR52 | G-protein coupled receptor 52 |
| GPR6 | G-protein coupled receptor 6 |
| GPR61 | G-protein coupled receptor 61 |
| GPR62 | G-protein coupled receptor 62 |
| GPR63 | Probable G-protein coupled receptor 63 |
| GPR65 | Psychosine receptor |
| GPR68 | Ovarian cancer G-protein coupled receptor 1 |
| GPR75 | Probable G-protein coupled receptor 75 |
| GPR78 | G-protein coupled receptor 78 |
| GPR82 | Probable G-protein coupled receptor 82 |
| GPR85 | Probable G-protein coupled receptor 85 |
| GPR87 | G-protein coupled receptor 87 |
| GPR88 | Probable G-protein coupled receptor 88 |
| GPRC5A | Retinoic acid-induced protein 3 |
| GPRC5B | G-protein coupled receptor family C group 5 member B |
| GPRC5C | G-protein coupled receptor family C group 5 member C |
| GPRC5D | G-protein coupled receptor family C group 5 member D |
| HCAR1 | Hydroxycarboxylic acid receptor 1 |
| HCAR3 | Hydroxycarboxylic acid receptor 3 |
| LPAR6 | Lysophosphatidic acid receptor 6 |
| MRGPRE | Mas-related G-protein coupled receptor member E |
| MRGPRF | Mas-related G-protein coupled receptor member F |
| MRGPRG | Mas-related G-protein coupled receptor member G |
| MRGPRX1 | Mas-related G-protein coupled receptor member X1 |
| MRGPRX2 | Mas-related G-protein coupled receptor member X2 |
| MRGPRX3 | Mas-related G-protein coupled receptor member X3 |
| MRGPRX4 | Mas-related G-protein coupled receptor member X4 |
| NPBWR1 | Neuropeptides B/W receptor type 1 |
| NPBWR2 | Neuropeptides B/W receptor type 2 |
| OXER1 | Oxoeicosanoid receptor 1 |
| OXGR1 | 2-oxoglutarate receptor 1 |
| P2RY10 | Putative P2Y purinoceptor 10 |
| PROKR1 | Prokineticin receptor 1 |
| QRFPR | Pyroglutamylated RF-amide peptide receptor |
| RXFP4 | Relaxin-3 receptor 2 |
| TAAR2 | Trace amine-associated receptor 2 |
| TAAR3P | Putative trace amine-associated receptor 3 |
| TAAR8 | Trace amine-associated receptor 8 |
| TAAR9 | Trace amine-associated receptor 9 |
| TAS2R1 | Taste receptor type 2 member 1 |
| TAS2R10 | Taste receptor type 2 member 10 |
| TAS2R13 | Taste receptor type 2 member 13 |
| TAS2R14 | Taste receptor type 2 member 14 |
| TAS2R16 | Taste receptor type 2 member 16 |
| TAS2R19 | Taste receptor type 2 member 19 |
| TAS2R20 | Taste receptor type 2 member 20 |
| TAS2R3 | Taste receptor type 2 member 3 |
| TAS2R30 | Taste receptor type 2 member 30 |
| TAS2R31 | Taste receptor type 2 member 31 |
| TAS2R39 | Taste receptor type 2 member 39 |
| TAS2R4 | Taste receptor type 2 member 4 |
| TAS2R40 | Taste receptor type 2 member 40 |
| TAS2R41 | Taste receptor type 2 member 41 |
| TAS2R42 | Taste receptor type 2 member 42 |
| TAS2R43 | Taste receptor type 2 member 43 |
| TAS2R46 | Taste receptor type 2 member 46 |
| TAS2R5 | Taste receptor type 2 member 5 |
| TAS2R50 | Taste receptor type 2 member 50 |
| TAS2R60 | Taste receptor type 2 member 60 |
| TAS2R7 | Taste receptor type 2 member 7 |
| TAS2R8 | Taste receptor type 2 member 8 |
| TAS2R9 | Taste receptor type 2 member 9 |
