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Understudied Proteins

The implementation phase of the IDG program will focus on elucidating the function of understudied proteins from three protein families; non-olfactory GPCRs, ion channels, and protein kinases. This page lists protein targets that have been identified by the IDG program that are currently understudied. This page was last updated on June 11, 2019.

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Eligible Kinases
GeneProtein Name
ADCK1Uncharacterized aarF domain-containing protein kinase 1
ADCK2Uncharacterized aarF domain-containing protein kinase 2
ADCK5Uncharacterized aarF domain-containing protein kinase 5
ALPK2Alpha-protein kinase 2
ALPK3Alpha-protein kinase 3
BCKDK[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
BRSK1Serine/threonine-protein kinase BRSK1
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G
CAMKK1Calcium/calmodulin-dependent protein kinase kinase 1
CAMKVCaM kinase-like vesicle-associated protein
CDC42BPASerine/threonine-protein kinase MRCK alpha
CDC42BPBSerine/threonine-protein kinase MRCK beta
CDC42BPGSerine/threonine-protein kinase MRCK gamma
CDK10Cyclin-dependent kinase 10
CDK11ACyclin-dependent kinase 11A
CDK11BCyclin-dependent kinase 11B
CDK12Cyclin-dependent kinase 12
CDK13Cyclin-dependent kinase 13
CDK14Cyclin-dependent kinase 14
CDK15Cyclin-dependent kinase 15
CDK16Cyclin-dependent kinase 16
CDK17Cyclin-dependent kinase 17
CDK18Cyclin-dependent kinase 18
CDK19Cyclin-dependent kinase 19
CDK20Cyclin-dependent kinase 20
CDKL1Cyclin-dependent kinase-like 1
CDKL2Cyclin-dependent kinase-like 2
CDKL3Cyclin-dependent kinase-like 3
CDKL4Cyclin-dependent kinase-like 4
CLK3Dual specificity protein kinase CLK3
CLK4Dual specificity protein kinase CLK4
COQ8AAtypical kinase COQ8A, mitochondrial
COQ8BAtypical kinase COQ8B, mitochondrial
CSNK1A1LCasein kinase I isoform alpha-like
CSNK1G1Casein kinase I isoform gamma-1
CSNK1G2Casein kinase I isoform gamma-2
CSNK1G3Casein kinase I isoform gamma-3
CSNK2A3Casein kinase II subunit alpha 3
DCLK3Serine/threonine-protein kinase DCLK3
DSTYKDual serine/threonine and tyrosine protein kinase
DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1B
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3
DYRK4Dual specificity tyrosine-phosphorylation-regulated kinase 4
EEF2KEukaryotic elongation factor 2 kinase
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2
HIPK1Homeodomain-interacting protein kinase 1
HIPK3Homeodomain-interacting protein kinase 3
HIPK4Homeodomain-interacting protein kinase 4
ICKSerine/threonine-protein kinase ICK
LMTK2Serine/threonine-protein kinase LMTK2
LMTK3Serine/threonine-protein kinase LMTK3
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1
LTKLeukocyte tyrosine kinase receptor
MAP3K10Mitogen-activated protein kinase kinase kinase 10
MAP3K14Mitogen-activated protein kinase kinase kinase 14
MAP3K15Mitogen-activated protein kinase kinase kinase 15
MAP3K21Mitogen-activated protein kinase kinase kinase 21
MAPK15Mitogen-activated protein kinase 15
MAPK4Mitogen-activated protein kinase 4
MARK1Serine/threonine-protein kinase MARK1
MARK3MAP/microtubule affinity-regulating kinase 3
MARK4MAP/microtubule affinity-regulating kinase 4
MAST2Microtubule-associated serine/threonine-protein kinase 2
MAST3Microtubule-associated serine/threonine-protein kinase 3
MAST4Microtubule-associated serine/threonine-protein kinase 4
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2
NEK1Serine/threonine-protein kinase Nek1
NEK10Serine/threonine-protein kinase Nek10
NEK11Serine/threonine-protein kinase Nek11
NEK3Serine/threonine-protein kinase Nek3
NEK4Serine/threonine-protein kinase Nek4
NEK5Serine/threonine-protein kinase Nek5
NEK6Serine/threonine-protein kinase Nek6
NEK7Serine/threonine-protein kinase Nek7
NEK9Serine/threonine-protein kinase Nek9
NIM1KSerine/threonine-protein kinase NIM1
NRBP2Nuclear receptor-binding protein 2
NRKNik-related protein kinase
NUAK2NUAK family SNF1-like kinase 2
PAK3Serine/threonine-protein kinase PAK 3
PAK5Serine/threonine-protein kinase PAK 5
PAK6Serine/threonine-protein kinase PAK 6
PAN3PAN2-PAN3 deadenylation complex subunit PAN3
PDIK1LSerine/threonine-protein kinase PDIK1L
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
PI4KAPhosphatidylinositol 4-kinase alpha
PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
PIK3C2GPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma
PKMYT1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
PKN3Serine/threonine-protein kinase N3
PNCKCalcium/calmodulin-dependent protein kinase type 1B
POMKProtein O-mannose kinase
PRKACBcAMP-dependent protein kinase catalytic subunit beta
PRKACGcAMP-dependent protein kinase catalytic subunit gamma
PRPF4BSerine/threonine-protein kinase PRP4 homolog
PSKH1Serine/threonine-protein kinase H1
PSKH2Serine/threonine-protein kinase H2
PXKPX domain-containing protein kinase-like protein
RIOK1Serine/threonine-protein kinase RIO1
RIOK2Serine/threonine-protein kinase RIO2
RIOK3Serine/threonine-protein kinase RIO3
RPS6KC1Ribosomal protein S6 kinase delta-1
RPS6KL1Ribosomal protein S6 kinase-like 1
SBK2Serine/threonine-protein kinase SBK2
SBK3Uncharacterized serine/threonine-protein kinase SBK3
SCYL2SCY1-like protein 2
SCYL3Protein-associating with the carboxyl-terminal domain of ezrin
SGK494Uncharacterized serine/threonine-protein kinase SgK494
SRPK3SRSF protein kinase 3
STK17ASerine/threonine-protein kinase 17A
STK17BSerine/threonine-protein kinase 17B
STK19Serine/threonine-protein kinase 19
STK3Serine/threonine-protein kinase 3
STK31Serine/threonine-protein kinase 31
STK32ASerine/threonine-protein kinase 32A
STK32BSerine/threonine-protein kinase 32B
STK32CSerine/threonine-protein kinase 32C
STK33Serine/threonine-protein kinase 33
STK36Serine/threonine-protein kinase 36
STK38LSerine/threonine-protein kinase 38-like
STK40Serine/threonine-protein kinase 40
STKLD1Serine/threonine kinase-like domain-containing protein STKLD1
TAOK1Serine/threonine-protein kinase TAO1
TAOK2Serine/threonine-protein kinase TAO2
TBCKTBC domain-containing protein kinase-like protein
TESK1Dual specificity testis-specific protein kinase 1
TESK2Dual specificity testis-specific protein kinase 2
TLK1Serine/threonine-protein kinase tousled-like 1
TLK2Serine/threonine-protein kinase tousled-like 2
TP53RKEKC/KEOPS complex subunit TP53RK
TSSK1BTestis-specific serine/threonine-protein kinase 1
TSSK2Testis-specific serine/threonine-protein kinase 2
TSSK3Testis-specific serine/threonine-protein kinase 3
TSSK4Testis-specific serine/threonine-protein kinase 4
TSSK6Testis-specific serine/threonine-protein kinase 6
TTBK1Tau-tubulin kinase 1
TTBK2Tau-tubulin kinase 2
ULK4Serine/threonine-protein kinase ULK4
VRK2Serine/threonine-protein kinase VRK2
VRK3Inactive serine/threonine-protein kinase VRK3
WEE2Wee1-like protein kinase 2
WNK2Serine/threonine-protein kinase WNK2
WNK3Serine/threo+B1:C151nine-protein kinase WNK3
BRSK2Serine/threonine-protein kinase BRSK2
Eligible Ion Channels
GeneProtein Name
ASIC4Acid-sensing ion channel 4
BEST4Bestrophin-4
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4
CACNG1Voltage-dependent calcium channel gamma-1 subunit
CACNG3Voltage-dependent calcium channel gamma-3 subunit
CACNG4Voltage-dependent calcium channel gamma-4 subunit
CACNG5Voltage-dependent calcium channel gamma-5 subunit
CACNG6Voltage-dependent calcium channel gamma-6 subunit
CACNG7Voltage-dependent calcium channel gamma-7 subunit
CACNG8Voltage-dependent calcium channel gamma-8 subunit
CALHM4Calcium homeostasis modulator protein 4
CALHM5Calcium homeostasis modulator protein 5
CALHM6Calcium homeostasis modulator protein 6
CATSPER2Cation channel sperm-associated protein 2
CHRNA10Neuronal acetylcholine receptor subunit alpha-10
CHRNB1Acetylcholine receptor subunit beta
CLCA4Calcium-activated chloride channel regulator 4
CLCC1Chloride channel CLIC-like protein 1
CLCN6Chloride transport protein 6
CLIC6Chloride intracellular channel protein 6
GABRPGamma-aminobutyric acid receptor subunit pi
GPR89AGolgi pH regulator A
GPR89BGolgi pH regulator B
GRID1Glutamate receptor ionotropic, delta-1
KCNA6Potassium voltage-gated channel subfamily A member 6
KCNA7Potassium voltage-gated channel subfamily A member 7
KCNAB2Voltage-gated potassium channel subunit beta-2
KCNAB3Voltage-gated potassium channel subunit beta-3
KCND1Potassium voltage-gated channel subfamily D member 1
KCNG2Potassium voltage-gated channel subfamily G member 2
KCNG3Potassium voltage-gated channel subfamily G member 3
KCNG4Potassium voltage-gated channel subfamily G member 4
KCNH4Potassium voltage-gated channel subfamily H member 4
KCNH6Potassium voltage-gated channel subfamily H member 6
KCNH8Potassium voltage-gated channel subfamily H member 8
KCNJ15ATP-sensitive inward rectifier potassium channel 15
KCNJ18Inward rectifier potassium channel 18
KCNK12Potassium channel subfamily K member 12
KCNK7Potassium channel subfamily K member 7
KCNMB3Calcium-activated potassium channel subunit beta-3
KCNN1Small conductance calcium-activated potassium channel protein 1
KCNS1Potassium voltage-gated channel subfamily S member 1
KCNS2Potassium voltage-gated channel subfamily S member 2
LRRC38Leucine-rich repeat-containing protein 38
LRRC55Leucine-rich repeat-containing protein 55
PKD1L2Polycystic kidney disease protein 1-like 2
PKD1L3Polycystic kidney disease protein 1-like 3
PKD2L2Polycystic kidney disease 2-like 2 protein
PLLPPlasmolipin
SCN7ASodium channel protein type 7 subunit alpha
SLC26A1Sulfate anion transporter 1
TMC3Transmembrane channel-like protein 3
TMC4Transmembrane channel-like protein 4
TMC5Transmembrane channel-like protein 5
TMC7Transmembrane channel-like protein 7
TMEM38BTrimeric intracellular cation channel type B
TMEM63ACSC1-like protein 1
TMEM63BCSC1-like protein 2
TTYH1Protein tweety homolog 1
TTYH2Protein tweety homolog 2
Eligible GPCRs
GeneProtein Name
ADGRA1Adhesion G protein-coupled receptor A1
ADGRA3Adhesion G protein-coupled receptor A3
ADGRB2Adhesion G protein-coupled receptor B2
ADGRB3Adhesion G protein-coupled receptor B3
ADGRD1Adhesion G-protein coupled receptor D1
ADGRD2Adhesion G-protein coupled receptor D2
ADGRE1Adhesion G protein-coupled receptor E1
ADGRE3Adhesion G protein-coupled receptor E3
ADGRF1Adhesion G-protein coupled receptor F1
ADGRF2Adhesion G-protein coupled receptor F2
ADGRF3Adhesion G-protein coupled receptor F3
ADGRF4Adhesion G protein-coupled receptor F4
ADGRF5Adhesion G protein-coupled receptor F5
ADGRG2Adhesion G-protein coupled receptor G2
ADGRG3Adhesion G protein-coupled receptor G3
ADGRG4Adhesion G-protein coupled receptor G4
ADGRG5Adhesion G-protein coupled receptor G5
ADGRG7Adhesion G-protein coupled receptor G7
FZD10Frizzled-10
GNRHR2Putative gonadotropin-releasing hormone II receptor
GPR101Probable G-protein coupled receptor 101
GPR12G-protein coupled receptor 12
GPR135G-protein coupled receptor 135
GPR137Integral membrane protein GPR137
GPR139Probable G-protein coupled receptor 139
GPR141Probable G-protein coupled receptor 141
GPR142Probable G-protein coupled receptor 142
GPR146Probable G-protein coupled receptor 146
GPR149Probable G-protein coupled receptor 149
GPR150Probable G-protein coupled receptor 150
GPR151Probable G-protein coupled receptor 151
GPR152Probable G-protein coupled receptor 152
GPR153Probable G-protein coupled receptor 153
GPR156Probable G-protein coupled receptor 156
GPR157G-protein coupled receptor 157
GPR160Probable G-protein coupled receptor 160
GPR162Probable G-protein coupled receptor 162
GPR171Probable G-protein coupled receptor 171
GPR173Probable G-protein coupled receptor 173
GPR174Probable G-protein coupled receptor 174
GPR18N-arachidonyl glycine receptor
GPR19Probable G-protein coupled receptor 19
GPR20G-protein coupled receptor 20
GPR21Probable G-protein coupled receptor 21
GPR22G-protein coupled receptor 22
GPR25Probable G-protein coupled receptor 25
GPR26G-protein coupled receptor 26
GPR27Probable G-protein coupled receptor 27
GPR3G-protein coupled receptor 3
GPR3112-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
GPR32Probable G-protein coupled receptor 32
GPR34Probable G-protein coupled receptor 34
GPR37L1G-protein coupled receptor 37-like 1
GPR4G-protein coupled receptor 4
GPR45Probable G-protein coupled receptor 45
GPR52G-protein coupled receptor 52
GPR6G-protein coupled receptor 6
GPR61G-protein coupled receptor 61
GPR62G-protein coupled receptor 62
GPR63Probable G-protein coupled receptor 63
GPR65Psychosine receptor
GPR68Ovarian cancer G-protein coupled receptor 1
GPR75Probable G-protein coupled receptor 75
GPR78G-protein coupled receptor 78
GPR82Probable G-protein coupled receptor 82
GPR85Probable G-protein coupled receptor 85
GPR87G-protein coupled receptor 87
GPR88Probable G-protein coupled receptor 88
GPRC5ARetinoic acid-induced protein 3
GPRC5BG-protein coupled receptor family C group 5 member B
GPRC5CG-protein coupled receptor family C group 5 member C
GPRC5DG-protein coupled receptor family C group 5 member D
HCAR1Hydroxycarboxylic acid receptor 1
HCAR3Hydroxycarboxylic acid receptor 3
LPAR6Lysophosphatidic acid receptor 6
MRGPREMas-related G-protein coupled receptor member E
MRGPRFMas-related G-protein coupled receptor member F
MRGPRGMas-related G-protein coupled receptor member G
MRGPRX1Mas-related G-protein coupled receptor member X1
MRGPRX2Mas-related G-protein coupled receptor member X2
MRGPRX3Mas-related G-protein coupled receptor member X3
MRGPRX4Mas-related G-protein coupled receptor member X4
NPBWR1Neuropeptides B/W receptor type 1
NPBWR2Neuropeptides B/W receptor type 2
OXER1Oxoeicosanoid receptor 1
OXGR12-oxoglutarate receptor 1
P2RY10Putative P2Y purinoceptor 10
PROKR1Prokineticin receptor 1
QRFPRPyroglutamylated RF-amide peptide receptor
RXFP4Relaxin-3 receptor 2
TAAR2Trace amine-associated receptor 2
TAAR3PPutative trace amine-associated receptor 3
TAAR8Trace amine-associated receptor 8
TAAR9Trace amine-associated receptor 9
TAS2R1Taste receptor type 2 member 1
TAS2R10Taste receptor type 2 member 10
TAS2R13Taste receptor type 2 member 13
TAS2R14Taste receptor type 2 member 14
TAS2R16Taste receptor type 2 member 16
TAS2R19Taste receptor type 2 member 19
TAS2R20Taste receptor type 2 member 20
TAS2R3Taste receptor type 2 member 3
TAS2R30Taste receptor type 2 member 30
TAS2R31Taste receptor type 2 member 31
TAS2R39Taste receptor type 2 member 39
TAS2R4Taste receptor type 2 member 4
TAS2R40Taste receptor type 2 member 40
TAS2R41Taste receptor type 2 member 41
TAS2R42Taste receptor type 2 member 42
TAS2R43Taste receptor type 2 member 43
TAS2R46Taste receptor type 2 member 46
TAS2R5Taste receptor type 2 member 5
TAS2R50Taste receptor type 2 member 50
TAS2R60Taste receptor type 2 member 60
TAS2R7Taste receptor type 2 member 7
TAS2R8Taste receptor type 2 member 8
TAS2R9Taste receptor type 2 member 9

This page last reviewed on January 25, 2024