Illuminating the Druggable Genome

The NIH Common Fund was enacted into law by Congress through the 2006 NIH Reform Act and is managed by the Office of Strategic Coordination within the NIH Office of the Director. The Common Fund supports cross-cutting trans-NIH initiatives to catalyze new areas of science. Common Fund programs address emerging scientific opportunities and pressing challenges in biomedical research that no single NIH Institute or Center (IC) can address on its own but are of high priority for the NIH as a whole. The Common Fund is a unique resource at NIH, functioning as a “venture capital” space where high-risk, innovative endeavors with the potential for extraordinary impact can be supported. Common Fund programs are short-term, goal-driven strategic investments, with deliverables intended to catalyze research across multiple biomedical research disciplines. More information is available at http://www.commonfund.nih.gov.

The overall goal of the IDG Program is to catalyze research in areas of biology that are currently understudied but that have high potential to impact human health by:

• Identifying biochemical, cellular or animal model phenotypes for understudied proteins from druggable gene families.
• Enabling further investigation of those proteins by providing reagents and tools.
• Generating, maintaining and facilitating the use of a minable knowledge base.
• More information is available at https://commonfund.nih.gov/idg.

The IDG program is focused on three families of proteins, protein kinases, G protein-coupled receptors and ion channels. Detailed information about the goals of each of these projects along with milestones and experimental workflow can be found here. Please email DruggableGenome@mail.nih.gov if you have additional questions.

This FOA is intended to fund small research projects on eligible proteins that can be carried out within one year and are limited to $100,000 direct costs. These projects should focus on generation of preliminary data and tools around eligible understudied protein(s) identified by the IDG Program with the intent of elucidating the function of these proteins in the context of human disease and obtaining sufficient preliminary and/or validation data for subsequent R01 applications or drug discovery projects. More information can be found in the full FOA .

All IDG-generated resources can be found either via the IDG Program's data repository and search engine Pharos, which includes all relevant data associated with understudied proteins collected by the IDG Program, or through the Druggable Genome Protein Illumination Timelines, on the IDG Consortium's website, where applicants can explore available tools developed by the IDG Consortium. Applicants must include an IDG Resource Usage Statement. This statement should provide adequate information concerning why (or why not) IDG resources were used. If the appropriate resources are not available, the applicant should indicate how their work will add value to the IDG program. Applicants should not propose work identical to that currently being performed by the IDG Consortium (consult the DruggableGenome.net website for current IDG Consortium projects).

Projects that propose work on proteins not listed in the FOA will not be responsive and will not be reviewed. Proteins included on the IDG-eligible protein list have been found to be of the highest priority to the IDG program and are the focus of this FOA. IDG-eligible proteins listed in the FOA meet at least two of the following three criteria: the protein (1) has a low number of publications/citations, with a Jensen Pubmed score of <50, (2) has minimal or no NIH funding and/or (3) has reagents developed by the IDG Consortium available for characterization of the protein in the context of disease. Additional proteins, including well studied proteins, may only be used as controls for experiments involving IDG-eligible proteins from the approved list. The control proteins may not be the focus of experimental work.

This is acceptable. However, sufficient justification should be provided to indicate why particular protein(s) were chosen for study. Those projects employing methods that identify multiple proteins for study from the IDG-eligible lists require justification as to why those proteins were chosen, beyond the fact that they are on the eligible protein lists provided. In addition, applicants should remember that their project must be achievable within one year and that direct costs are capped at $100,000. Applicants should not propose an overly ambitious project that proposes the study of more proteins or methods than would be feasible for this award budget.

While not mandatory, contacting NIH early in the process will help you to determine if you are eligible to apply and if you are proposing something that would be responsive to this FOA . The NIH contact for RFA-RM-20-019 is: ,Karlie Sharma, Ph.D . National Center for Advancing Translational Sciences (NCATS) Email: DruggableGenome@mail.nih.gov

No. For this FOA the project period is limited to 1 year and $100,000 direct costs.

Yes, there is no prohibition on the number of applications an institution may submit, provided the applications are scientifically distinct.

Although a letter of intent is not required, is not binding and does not enter into the review of a subsequent application, the information that it contains allows NIH to estimate the potential review workload and plan the review.

This is not required.

Foreign components, as defined in the NIH Grants Policy Statement , are allowed. Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

All applications, regardless of the amount of direct costs requested for any one year, should address a Data Sharing Plan. The Plan should include the type of data to be shared, the timeline for sharing data and a statement indicating that the data will be shared with the IDG Resource Dissemination and Outreach Center (RDOC), which will be responsible for ensuring collected data, technical protocols and any other metadata collected under this FOA is made available through Pharos . Resources resulting from this work should be submitted to an appropriate repository and this information provided to the Resource Dissemination and Outreach Center (RDOC) consistent with the IDG Consortium's Policy for Resource Sharing. The Resource Sharing Plan must include a list of expected resources from the project and how they will be provided to the RDOC.

Applications will be evaluated for scientific and technical merit by a Special Emphasis Panel convened by the Center for Scientific Review (CSR), NIH. Following initial peer review, recommended applications will receive a second level of review by the NCATS Advisory Council. The following will be considered in making funding decisions:

• Scientific and technical merit of the proposed project as determined by scientific peer review.
• Availability of funds.
• Relevance of the proposed project to program priorities.
• Increasing the diversity of approaches applied to the study of understudied proteins.
• Evidence that the project will contribute to the understanding of understudied proteins.
• Usage of IDG-generated resources in developing and/or conducting proposed studies.