Extracellular RNA Communication

Advancing Extracellular RNA (exRNA) Communication Research: Single Extracellular Vesicle (EV) Sorting, Isolation, and Analysis of Cargo (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-028
PI Name Institution Name Title
CHIU, DANIEL T UNIVERSITY OF WASHINGTON Single Extracellular Vesicle Sorting and Analysis
DAS, SAUMYA (contact)
TALISMAN, TIJANA
VAN KEUREN-JENSEN, KENDALL
MASSACHUSETTS GENERAL HOSPITAL Molecular dissection and imaging of extracellular vesicles to define their origin and targets
GHIRAN, IONITA CALIN (contact)
JONES, JENNIFER
MILOSAVLJEVIC, ALEKSANDAR
BETH ISRAEL DEACONESS MEDICAL CENTER Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometry
REATEGUI, EDUARDO (contact)
KIM, YON SON BETTY
OHIO STATE UNIVERSITY Microfluidics Array Based Sorting, Isolation, and RNA Analysis in Single Extracellular V csicles
ROUTENBERG, DAVID AARON MESO SCALE DIAGNOSTICS, LLC Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signatures
WONG, DAVID T (contact)
HUANG, TONY JUN
KIM, SUNG
KIM, YONG
XIE, YA-HONG
UNIVERSITY OF CALIFORNIA LOS ANGELES Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and Biofluids

 

Advancing Extracellular RNA (exRNA) Communication Research: Improved Isolation and Analysis of exRNA-Carrier Subclasses (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-027
CHANG, HSUEH-CHIA UNIVERSITY OF NOTRE DAME High-Throughput Electrokinetic Fractionation and Analysis of Extracellular RNA Nano-Carriers
COFFEY, ROBERT J. (contact)
CHAREST, ALAIN 
VANDERBILT UNIVERSITY MEDICAL CENTER Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasma
LAURENT, LOUISE CHANG UNIVERSITY OF CALIFORNIA, SAN DIEGO Development and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargo

RAFFAI, ROBERT (contact)
MATEESCU, BOGDAN
VAN KEUREN-JENSEN, KENDALL

NORTHERN CALIFORNIA INSTITUTE/RES/EDU P.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using Microfluidic
WITWER, KENNETH W JOHNS HOPKINS UNIVERSITY Novel Separation Methods for exRNA Carriers: Extracellular Vesicles, Lipoprotein Particles, and Protein Aggregates

 

Data Management and Resource Repository (DMRR) on Extracellular RNA (U54 Clinical Trial Not Allowed) RFA-RM-18-026
PI Name Institution Name Title
MILOSAVLJEVIC, ALEKSANDAR (contact)
GALAS, DAVID J.
GERSTEIN, MARK BENDER
BAYLOR COLLEGE OF MEDICINE DATA MANAGEMENT AND RESOURCE REPOSITORY FOR THE EXRNA ATLAS PHASE II

 

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) PA-18-648
PI Name Institution Name Title
HERMANN, THOMAS C UNIVERSITY OF CALIFORNIA, SAN DIEGO 2019 RNA Nanotechnology GRC/GRS

 

Clinical Utility of Extracellular RNA for Biomarker Development (UH2/UH3) RFA-RM-12-013
In 2015, the awards below transitioned into their UH3 phase. The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the biomarkers.

PI Name Institution Name Title

CARTER, BOB S (contact)
HOCHBERG, FRED H

UNIVERSITY OF CALIFORNIA SAN DIEGO

exRNA Biomarkers for Human Glioma

DAS, SAUMYA (contact)
KWONG, RAYMOND Y
ROSENZWEIG, ANTHONY 
SABATINE, MARC S

BETH ISRAEL DEACONESS MEDICAL CENTER

Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI

FREEDMAN, JANE E

UNIV OF MASSACHUSETTS MED SCH WORCESTER

Extracellular RNAs: Biomarkers for Cardiovascular Risk and Disease

JENSEN, KENDALL(contact)
ADELSON, P. DAVID
HUENTELMAN, MATTHEW
KALANI, YASHAR

TRANSLATIONAL GENOMICS RESEARCH INST

exRNA signatures Predict Outcomes after brain injury

LAURENT, LOUISE C

UNIVERSITY OF CALIFORNIA SAN DIEGO

ExRNAs for Early Identification of Pregnancies at Risk for Placental Dysfunction

PATEL, TUSHAR

MAYO CLINIC JACKSONVILLE

Extracellular non-coding RNA biomarkers of hepatocellular cancer

SAUGSTAD, JULIE ANNE (contact)
QUINN, JOSEPH F

OREGON HEALTH AND SCI UNIVERSITY

Clinical Utility of MicroRNAs as Diagnostic Biomarkers of Alzheimers Disease

TUSCHL, THOMAS (contact)
SUTHANTHIRAN, MANIKKAM

ROCKEFELLER UNIVERSITY

Clinical utility of extracellular RNA as marker of kidney disease progression

WEINER, HOWARD L

BRIGHAM AND WOMEN'S HOSPITAL

Circulating MicroRNAs as Disease Biomarkers in Multiple Sclerosis

WONG, DAVID T

UNIVERSITY OF CALIFORNIA LOS ANGELES

Clinical Utility of Salivary ExRNA Biomarkers for Gastric Cancer Detection

 

Clinical Utility of Extracellular RNA for Therapy Development (UH2/UH3) RFA-RM-12-014

In August 2015, the awards below transitioned into their UH3 phase. The UH2 phase (first phase) of these awards focused on discovery and feasibility, while the UH3 phase will focus on testing and validation of the therapeutics.

PI Name Institution Name Title
ABDEL-MAGEED, ASIM, B TULANE UNIVERSITY OF LOUISIANA Targeting Tumor-Derived exRNA-Containing Microvesicles by High Throughput Screeni

ARONIN, NEIL

UNIV OF MASSACHUSETTS MED SCH WORCESTER

Exosome based therapeutics in Huntingtons disease

KRAIG, RICHARD P

UNIVERSITY OF CHICAGO

Exosome RNA-Therapeutics to Promote CNS Myelination

MATIN, AC STANFORD UNIVERSITY HER2-targeted exosomal delivery of therapeutic mRNA for enzyme pro-drug therapy

QUESENBERRY, PETER J

RHODE ISLAND HOSPITAL

Regulation of renal and bone marrow injury by extracellular vesicle non-coding RN

SCHMITTGEN, THOMAS D (contact)
PHELPS, MITCH A
UNIVERSITY OF FLORIDA Targeted delivery of microRNA-loaded microvesicle for cancer therapy

SOOD, ANIL K (contact)
CALIN, GEORGE A
LOPEZ-BERESTEIN, GABRIEL

UT MD ANDERSON CANCER CTR

Novel extra cellular RNA-based combinatorial RNA inhibition therapy

ZHANG, HUANG-GE (contact)
GUO, PEIXUAN

UNIVERSITY OF LOUISVILLE

Fruit exosome-like particles for therapeutic delivery of extracellular miRNAs

 

NIH Support for Conferences and Scientific Meetings (Parent R13/U13) PA-13-347
PI Name Institution Name Title
GUO, PEIXUAN

GORDON RESEARCH CONFERENCES

2015 RNA Nanotechnology Gordon Research Conference

QUESENBERRY, PETER J GORDON RESEARCH CONFERENCES 2016 Extracellular Vesicles Gordon Research Conference
WITWER, KENNETH W JOHNS HOPKINS UNIVERSITY

International Society for Extracellular Vesicles - Education Day & Meeting

WOODLAND, DAVID L. KEYSTONE CONFERENCE CENTER Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication

 

Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA (U01) RFA-RM-13-014
PI Name Institution Name Title

FREEDMAN, JANE E (contact)
GERSTEIN, MARK BENDER
MUKAMAL, KENNETH JAY
ODONNELL, CHRISTOPHER J

UNIV OF MASSACHUSETTS MED SCH WORCESTER

Racial and Ethnic Diversity in Human Extracellular RNA

GALAS, DAVID J. (contact)
NICKERSON, DEBORAH A
WANG, KAI

PACIFIC NORTHWEST RESEARCH INSTITUTE

Reference Profiles of Extracellular RNA in 4 Body Fluids of Healthy Humans

GHIRAN, IONITA CALIN

BETH ISRAEL DEACONESS MEDICAL CENTER

Impact of circadian rhythm in obtaining reference profiles of exRNAs in healthy in healthy individuals

LAURENT, LOUISE C

UNIVERSITY OF CALIFORNIA SAN DIEGO

Reference Profiles of ExRNAs in Normal Human Pregnancy

TEWARI, MUNEESH

UNIVERSITY OF MICHIGAN AT ANN ARBOR

Reference Profiles of ExRNA in Biofluids from Well-Defined Human Cohorts

WOODRUFF, PRESCOTT G (contact)
ERLE, DAVID J

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA

 

Data Management and Resource Repository (DMRR) on Extracellular RNA (U54) RFA-RM-12-010
PI Name Institution Name Title
MILOSAVLJEVIC, ALEKSANDAR (contact)
GALAS, DAVID J.
GERSTEIN, MARK BENDER
BAYLOR COLLEGE OF MEDICINE Data management and Resource Repository for the exRNA Atlas

 

Extracellular RNA Biogenesis, Biodistribution, Uptake, and Effector Function (U19) RFA-RM-12-012
PI Name Institution Name Title
BLELLOCH, ROBERT H UNIVERSITY OF CALIFORNIA-SAN FRANCISCO In Vivo Regulated Release and Function of Extracellular Small RNAs
BREAKEFIELD, XANDRA OWENS (contact)
CHAREST, ALAIN 
GOULD, STEPHEN J
KRICHEVSKY, ANNA M.
MEMPEL, THORSTEN ROMAN
MASSACHUSETTS GENERAL HOSP exRNA released by glioblastoma alters brain microenvironment
COFFEY, ROBERT J. VANDERBILT UNIVERSITY MED CTR Secreted RNA during CRC progression biogenesis function and clinical markers
MCMANUS, MICHAEL T UNIVERSITY OF CALIFORNIA-SAN FRANCISCO Genetic models for exRNA communication
TUSCHL, THOMAS ROCKEFELLER UNIVERSITY Definition of Serum Ribonucleoprotein Composition and its Regulation and Function

 

 

This page last reviewed on September 23, 2019