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Complement-ARIE Funded Research

Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional)
PI Name	Institution Name	Title
FERRER, MARC	National Center for Advancing, Translational Sciences	An Integrated Multiorgan Platform of 3D Microtissues to Model and Understand Interindividual Drug Susceptibility in Fibrotic Pathologies (3D-MOFIB)
GRIFFITH, LINDA G	Massachusetts Institute of Technology	NAMs for Clinical Translation of Therapeutics for Systemic Gynecology Diseases
RUSYN, IVAN	Texas A&M AgriLife Research	NAMs-Decisions Center: New Approach Methods for Decisions on Industrial and Consumer-Use Chemicals
SMIRNOVA, LENA	Johns Hopkins University	DROIDp – Drug Research Organoid-Integrated Development Platform: a Combinatorial NAM for Assessment of in vitro Learning and Memory in Drug and Chemical Testing
WELLS, JAMES M	Cincinnati Children's Hospital Medical Center	Patient-specific, combinatorial NAMs for gastrointestinal diseases and drug response prediction
ZHANG, SHRIKE Y	Brigham and Women's Hospital	Technology development center for integrative physiologic models of the human musculoskeletal system
WU, JOSEPH C	Stanford University	Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models

Complement-ARIE New Approach Methodologies (NAMs) Data Hub and Coordinating Center (U24 Clinical Trial Optional)
PI Name	Institution Name	Title
STOLOVITZKY, GUSTAVO	New York University School of Medicine	The NYU-Sage NAMs Data Hub and Coordinating Center: Harmonizing, Analyzing, and Disseminating New-Approach-Methodologies Data

Validation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs) OTA-25-003
PI Name	Institution Name	Title
ADAM, STACEY	FOUNDATION FOR THE NIH	Validation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs)

Complement Animal Research In Experimentation (Complement-ARIE) Challenge
Winners	Title
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	4D TISSUE FABRICATION OF HUMAN TISSUE MODELS
UNIVERSITY OF CINCINNATI	A SENSOR-ENHANCED ISOGENIC MODEL OF ALZHEIMER'S
CHEN, KEN	AGENT-BASED MODELS FOR ADOPTIVE CELL THERAPY
CHEN, WEIQIANG	CANCER IMMUNOTHERAPY CLINICAL TRIALS ON A CHIP
UNIVERSITY OF DELAWARE	CLICK CHEMISTRY MAGIC FOR DRUG SCREENING
PREDICTIVE, LLC.	DEVTOX-DEVELOPMENTAL TOXICITY PREDICTOR
HARTUNG, THOMAS	E-VALIDATION-UNLEASHING AI FOR VALIDATION
SNGH, SHANTANU	EXPLORING OMICS FOR LIVER TOXICITY ASSESSMENT
MICHIGAN STATE UNIVERSITY	FACING THE FUTURE OF MICROPHYSIOLOGICAL MODELING
REPROTOX BIOTECH, LLC.	FUTURE FERTILITY: AI-DRIVEN HUMAN MINI-TESTIS MODEL
PRESIDENT AND FELLOWS OF HARVARD COLLEGE ON BEHALF OF HARVARD MEDICAL SCHOOL	INTERPRETING BRAINS AND ARTIFICIAL NETWORKS
TAN, WEI	MACHINE LEARNING ASSISTED HTP TISSUE ARRAY
LUECHTEFELD, THOMAS, INSILICA, LLC.	NAMKG: LLM POWERED REGISTRY TO FOSTER NAM ADOPTION
TUFTS UNIVERSITY	NEURO-IMMUNO-CUTANEOUS HUMAN SKIN EQUIVALENT
LIN, HANG	ORGAN-ON-A-CHIP FOR STUDYING OSTEOARTHRITIS PAIN
SMIRNOVA, LENA	ORGANOID INTELLIGENCE (OI) - LEARNING IN A DISH
BRIGHAM AND WOMEN'S HOSPITAL	ORGANOID MODELING OF RHEUMATOID ARTHRITIS JOINTS
THE RECTOR AND VISITORS OF THE UNIVERSITY OF VIRGINIA	POPULATION DIVERSITY IN RESPONSES TO VACCINATION
MENON, RAMKUMAR	PREGNANCY ON CHIP TO IMPROVE REPRODUCTIVE HEALTH
YANG, HUAXIAO 'ADAM'	PULSE OF THE FUTURE: AI-HUMAN MEHC