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Complement-ARIE Funded Research

Complement-ARIE NAMs Technology Development Centers (TDC) #tdc

Complement-ARIE New Approach Methodologies (NAMs) Technology Development Centers (UM1 Clinical Trial Optional)
PI NameInstitution NameTitle
FERRER, MARCNational Center for Advancing, Translational SciencesAn Integrated Multiorgan Platform of 3D Microtissues to Model and Understand Interindividual Drug Susceptibility in Fibrotic Pathologies (3D-MOFIB)
GRIFFITH, LINDA GMassachusetts Institute of TechnologyNAMs for Clinical Translation of Therapeutics for Systemic Gynecology Diseases
RUSYN, IVANTexas A&M AgriLife ResearchNAMs-Decisions Center: New Approach Methods for Decisions on Industrial and Consumer-Use Chemicals
SMIRNOVA, LENAJohns Hopkins UniversityDROIDp – Drug Research Organoid-Integrated Development Platform: a Combinatorial NAM for Assessment of in vitro Learning and Memory in Drug and Chemical Testing
WELLS, JAMES MCincinnati Children's Hospital Medical CenterPatient-specific, combinatorial NAMs for gastrointestinal diseases and drug response prediction
ZHANG, SHRIKE YBrigham and Women's HospitalTechnology development center for integrative physiologic models of the human musculoskeletal system
WU, JOSEPH CStanford UniversityAdvancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models
SHEN, XILINGUniversity of Texas MD Anderson Cancer CenterOPTIMA: Oncology Precision Trials using Individualized Model Avatars

Complement-ARIE NAMs Reduction to Practice Challenge

Complement-ARIE New Approach Methodologies (NAMs) Reduction to Practice Challenge (Challenge Prize)
Team CaptainOrganizationTitle
STANTON, ALICEMassachusetts General Hospital Predictive Brain Combinatorial NAM
WANG, JUNGFENGQureator Inc.Combining vTIME and AI for IO Drug CRS Prediction
GORE, ROBYNWake Forest University Health SciencesHuman Lung Models for Anti-Fibrotic Drug Testing
GARNER, JOSEPHEndomimetics Inc.Combinatorial NAM for Human Atherosclerosis Model
CHEN, WEIQIANGCAR-T Chips TeamCAR-T Immunotherapy Clinical Trials on a Chip
KUO, CALVINStanford UniversityAI-integrated human skin immune organoids
LEE, JUNGWOOUniversity of Massachusetts - AmherstCombinatorial Human Bone Remodeling NAM Platform
OGLE, BRENDAUniversity of MinnesotaPACE-IT: Immune-Cardiac NAM for Med Device Testing
LU, X. LUCASFirst State Click-Chem SolutionsHigh-Throughput Human Tissue Remodeling & Toxicity
VARSHNEY, JYOTIKAVeriSIM Life, Inc.Combinatorial NAM for Endometriosis Drug Efficacy
STERN, JEFFRegenerative Research FoundationMulti-Brain Region Assembloid Combinatorial Models
COLLINS, JOHNBiopico Systems Inc.Multiorgan Predictive Biologic Toxicity Framework
JOSHI, PRANAVBioprinting Laboratories Inc.Human Brain Organoids to Predict DNT
CIRIT, MURATJavelin Biotech Inc.Precision dosing of oligonucleotide therapeutics
BENNET, ERICFrontier Bio CorporationNeuroTraX-AI
YANG, HSIH-TE (PAUL)Wake Forest University Health SciencesAI-Driven Antibody Repurposing for New Therapies
GULLAPALLI, RAMALiver-Combine ConsortiumLIVER-COMBINE: A Human Relevant NAM Platform
KLEIN, OPHIRCedars-Sinai Medical CenterGut Feelings: A GI Toxicity Prediction Engine
ROUNTREE, COREY28bio Inc.Plasticity Biomarkers in Human Cortical Organoids
NACHTIGALL, MITCHCellField Technologies IncMAJIC: The Future of Human Joint Drug Testing

Complement-ARIE NAMs Data Hub and Coordinating Center (NDHCC) #ndhcc

Complement-ARIE New Approach Methodologies (NAMs) Data Hub and Coordinating Center (U24 Clinical Trial Optional)
PI NameInstitution NameTitle
STOLOVITZKY, GUSTAVONew York University School of MedicineThe NYU-Sage NAMs Data Hub and Coordinating Center: Harmonizing, Analyzing, and Disseminating New-Approach-Methodologies Data 

 

Complement-ARIE Validation and Qualification Network (VQN)

Validation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs) OTA-25-003
PI NameInstitution NameTitle
ADAM, STACEY FOUNDATION FOR THE NIHValidation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs)

 

Complement-ARIE Challenge Prize 

Complement Animal Research In Experimentation (Complement-ARIE) Challenge
WinnersTitle
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO4D TISSUE FABRICATION OF HUMAN TISSUE MODELS
UNIVERSITY OF CINCINNATIA SENSOR-ENHANCED ISOGENIC MODEL OF ALZHEIMER'S
CHEN, KENAGENT-BASED MODELS FOR ADOPTIVE CELL THERAPY
CHEN, WEIQIANGCANCER IMMUNOTHERAPY CLINICAL TRIALS ON A CHIP
UNIVERSITY OF DELAWARECLICK CHEMISTRY MAGIC FOR DRUG SCREENING
PREDICTIVE, LLC.DEVTOX-DEVELOPMENTAL TOXICITY PREDICTOR
HARTUNG, THOMASE-VALIDATION-UNLEASHING AI FOR VALIDATION
SNGH, SHANTANUEXPLORING OMICS FOR LIVER TOXICITY ASSESSMENT
MICHIGAN STATE UNIVERSITYFACING THE FUTURE OF MICROPHYSIOLOGICAL MODELING
REPROTOX BIOTECH, LLC.FUTURE FERTILITY: AI-DRIVEN HUMAN MINI-TESTIS MODEL
PRESIDENT AND FELLOWS OF HARVARD COLLEGE ON BEHALF OF HARVARD MEDICAL SCHOOLINTERPRETING BRAINS AND ARTIFICIAL NETWORKS
TAN, WEIMACHINE LEARNING ASSISTED HTP TISSUE ARRAY
LUECHTEFELD, THOMAS, INSILICA, LLC.NAMKG: LLM POWERED REGISTRY TO FOSTER NAM ADOPTION
TUFTS UNIVERSITYNEURO-IMMUNO-CUTANEOUS HUMAN SKIN EQUIVALENT
LIN, HANGORGAN-ON-A-CHIP FOR STUDYING OSTEOARTHRITIS PAIN
SMIRNOVA, LENAORGANOID INTELLIGENCE (OI) - LEARNING IN A DISH
BRIGHAM AND WOMEN'S HOSPITALORGANOID MODELING OF RHEUMATOID ARTHRITIS JOINTS
THE RECTOR AND VISITORS OF THE UNIVERSITY OF VIRGINIAPOPULATION DIVERSITY IN RESPONSES TO VACCINATION
MENON, RAMKUMARPREGNANCY ON CHIP TO IMPROVE REPRODUCTIVE HEALTH
YANG, HUAXIAO 'ADAM'PULSE OF THE FUTURE: AI-HUMAN MEHC

 

This page last reviewed on July 29, 2026

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