Complement-ARIE Concept Planning 

The NIH is conducting planning activities to inform a potential Common Fund research program called Complement Animal Research In Experimentation (Complement-ARIE) aimed at development, standardization, validation, and use of new methods and approaches that will more accurately model human biology, known as New Approach Methodologies (NAMs). These NAMs are intended to more accurately model human biology, and that would complement, or in some cases, replace traditional models, transforming the way we do basic, translational, and clinical sciences. 

Complement-ARIE Concept Listening Sessions

As part of the planning activities, the Common Fund hosted three public listening sessions. These listening sessions brought together key representatives from multiple sectors, including industry and academic partners, non-government organization representatives, and U.S. government and international partners, to gain insight into current opportunities and roadblocks in NAM development unique to their fields.  

Sessions explored these questions:

• Where are animal models insufficient to answer questions about human biology and disease? 
• What are the specific areas of science that could benefit from development of human-relevant NAMs? 
• Where do NAMs show promise in modeling population diversity and susceptibility and what additional research is needed to further those objectives? 
• What are the greatest opportunities for progress in NAMs in the next five years? In the next ten years?
• What are current limitations of NAMs and how could they be addressed? 
• What’s needed for successful application and utility of NAMs and what are obstacles to implementation? 
• What are the challenges and needs around validation of NAMs for regulatory application?

Summaries of these listening sessions are forthcoming. 

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To learn more about related work being done at NIH, visit: NIH NCATS Tissue Chip for Drug Screening Program