Accessible Videos

Dr Geert-Jan Boons from the University of Georgia discusses his research which focuses on the development of an automated platform for the enzyme-mediated assembly of glycans


View a non-audio-described version of the video: https://youtu.be/Kcn7im3_zlA

Dr. Carolyn Bertozzi from Stanford University discusses her research which focuses on combining glycobiology and mass spectrometry.

View a non-audio-described version of the video: https://youtu.be/uSp2fk65M-E

On April 24, 2019 the NIH Common Fund’s Gabriella Miller Kids First Pediatric Research Program (Kids First) hosted a public webinar. The webinar featured presentations from Kids First investigators and NIH staff. This webinar covered new features of the Kids First Gabriella Miller Kids First Data Resource Portal, and an update on the progress of the Kids First Program.

The presentations follow this schedule:
• 0-30min: Gabriella Miller Kids First Data Resource Portal Overview & New Features - Adam Resnick, Ph.D. and Allison Heath, Ph.D. of Children’s Hospital of Philadelphia and Vincent Ferretti, Ph.D. of Sainte-Justine University Hospital
• 30min-1 hour: “De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders”- Wendy Chung, M.D., Ph.D. of Columbia University (https://www.ncbi.nlm.nih.gov/pubmed/30532227)
• 1 hour to 1:18: NIH Kids First Program Overview and Update - NIH Staff

Link to non-audio described video: https://youtu.be/VEMGMLA1bUQ

For more information about the Undiagnosed Diseases Network (UDN) visit our website at https://commonfund.nih.gov/diseases/h...

UDN researchers from Baylor College of Medicine describe how the use a team science approach that brings together laboratory researchers and clinicians to solve some of the most difficult medical cases. In the particular case described in this video demonstrates how Baylor Model Organisms Screening Center was able to discover a rare neurological disorder characterized by delayed development, intellectual disability, abnormal facial development and reduced response to pain using fruit flies to study potential disease genes.

For a version without audio descriptions, follow this link: https://www.youtube.com/watch?v=GapmlgWRQFQ

Follow this link to for a version of the video that does not include audio descriptions: https://www.youtube.com/watch?v=BSRgNEJZ0zw

The National Institutes of Health’s High-Risk, High-Reward Research program was created to accelerate the pace of biomedical and behavioral breakthroughs by supporting exceptional, creative scientists with innovative ideas through four NIH Director’s awards with annual funding opportunities.

Learn more: https://commonfund.nih.gov/highrisk

The goal of the Gabriella Miller Kids First Pediatric Research Program (Kids First) is to help researchers uncover new insights into the biology of childhood cancer and structural birth defects, including the discovery of shared genetic pathways between these disorders. Kids First is achieving this goal through two initiatives: 1) identifying children with childhood cancer and structural birth defects and their families for whole genome sequencing; and 2) developing the Gabriella Miller Kids First Data Resource-- a large-scale database of clinical and genetic data from patients and families directly affected by with childhood cancers and structural birth defects. The Kids First program continues to make interoperable data and unique data analysis tools available to investigators for concurrent study, and to engage the research community using these resources in activities such as integration, curation, data harmonization and workflow development which further increase the value of Kids First data resources. The research supported by Kids First is poised to shift the scientific landscape for patients and patient families who are experiencing childhood cancer and structural birth defects.

For more information on the Gabriella Miller Kids First Pediatric Research program, visit our website at:
https://commonfund.nih.gov/KidsFirst

For more details about the NIH Common Fund’s Nutrition for Precision Health, powered by the All of Us Research Program, visit: https://commonfund.nih.gov/nutritionforprecisionhealth.

The goal of the NIH Common Fund’s Nutrition for Precision Health, powered by the All of Us Research Program (NHP), is to develop algorithms that predict individual responses to food and dietary patterns. The NPH program will build on recent advances in biomedical science including artificial intelligence (AI), microbiome research, as well as the infrastructure and large, diverse participant group of the All of Us Research Program. These advances provide unprecedented opportunities to generate new data to provide insight into precision nutrition.

The NPH program is currently enrolling participants into its study. To take part in this exciting opportunity, please visit: https://nutritionforprecisionhealth.org/

The NIH Common Fund's Somatic Mosaicism across Human Tissues (SMaHT) Network aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease. We all have personal genomes that are composed of the DNA sequence we inherit and of changes to that DNA sequence that occur over time in individual cells. Somatic mosaicism refers to the post-conception changes to our DNA that lead to genetic variation among cells within an individual. We know that somatic mosaicism can lead to diseases like cancer, but we don't know how much somatic mosaicism there is in our tissues or how much it influences human biology. The goal of the SMaHT Network is to catalyze research on the impact of somatic mosaicism on human development and disease by discovering and cataloging the extent of somatic mosaicism in human tissues.

Find out more at our website: https://commonfund.nih.gov/smaht
And follow us on social media at: @NIH_CommonFund, #SMaHTnetwork

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program seeks to accelerate development of therapeutic devices that modulate electrical activity in nerves to improve organ function. In this SPARC Plug Fireside Chat video series you will hear from SPARC-funded researchers and peers about their latest scientific discoveries, from the bench to the bedside. In our second video, listen to a conversation between Dr. Tim Bruns and Dr. Paul Yoo as they chat about how computational modeling has helped inform the development of new neuromodulation therapies for bladder dysfunction, the benefits of SPARC Portal open science resources, and the exciting potential of bioelectronic medicine to improve health. Learn more about SPARC-funded research projects at https://go.usa.gov/xyFmD


The SPARC program is a trans-NIH effort managed by the NIH Common Fund in the Office of the Director and supported by several NIH Institutes and Centers, including NIBIB, NINDS, NIDDK, and NCATS. Learn more about the NIH SPARC program at https://go.usa.gov/xyFmQ and access SPARC datasets, maps, and more at sparc.science. Keep up with the latest news by following our Twitter (@NIH_CommonFund and @sparc_science), Facebook (@NIHCommonFund), and YouTube (@sparc.science) accounts.

The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program seeks to accelerate development of therapeutic devices that modulate electrical activity in nerves to improve organ function. In this SPARC Plug Fireside Chat video series, you will hear from SPARC-funded researchers and peers about their latest scientific discoveries, from the bench to the bedside. In our first video, hear from Dr. Charles Horn and Dr. Greg O’Grady as they chat about the latest stomach and colon disorder research, how SPARC Portal resources may help target new therapies for the gut, and the exciting potential of bioelectronic medicine to improve health. Learn more about SPARC-funded research projects at https://go.usa.gov/xyFmD

The SPARC program is a trans-NIH effort managed by the NIH Common Fund in the Office of the Director and supported by several NIH Institutes and Centers, including NIBIB, NINDS, NIDDK, and NCATS. Learn more about the NIH SPARC program at https://go.usa.gov/xyFmQ and access SPARC datasets, maps, and more at sparc.science. Keep up with the latest news by following our Twitter (@NIH_CommonFund and @sparc_science), Facebook (@NIHCommonFund), and YouTube (@sparc.science) accounts.

For more information on the Cellular Senescence Network (SenNet) program, visit our website at: https://commonfund.nih.gov/senescence
A cell dividing into two cells is a hallmark of human development. Over time, our bodies accumulate a small number of cells that no longer divide. These “senescent” cells are a rare type of cells that play both positive and negative roles in biological processes, either directly or through the release of molecules that affect neighboring cells. The rarity and diversity of these cells previously made them difficult to identify and study, but recent advances in studying individual cells, or single-cell analysis, now make it possible. Therapeutics called “senolytics” are being developed to target senescent cells and remove them from the body, however a deeper understanding of cellular senescence is needed to ensure therapies like senolytics encourage the beneficial effects of senescent cells while suppressing their tissue-damaging effects.
For this reason, the Common Fund’s Cellular Senescence Network (SenNet) program was established to comprehensively identify and characterize the differences in senescent cells across the body, across various states of human health, and across the lifespan. SenNet will develop innovative tools and technologies for the study of senescent cells and provide publicly accessible maps and atlases of senescent cells. These data and resources would otherwise be difficult to achieve through individual efforts, and will accelerate the ability of biomedical researchers to develop therapeutics that target cellular senescence and improve human health.

The SPARC Plug Tools & Tech video series features SPARC-funded research tools and technologies. In our eighth video, learn about a biosensor called Urological MOnitor of Conscious Activity (UroMOCA) that SPARC researchers are developing to help improve therapies for bladder dysfunction by providing a reproducible way to assess health and bladder function. UroMOCA is one of the many tools and technologies being developed by SPARC researchers to help advance therapies that manipulate peripheral nerves and their electrical signals to improve treatment of diseases and conditions such as hypertension, bladder dysfunction, type II diabetes, and more. Learn more about SPARC-funded research projects at https://go.usa.gov/xyFmD

The SPARC program is a trans-NIH effort managed by the NIH Common Fund in the Office of the Director and supported by NIBIB, NINDS, NIDDK, and NCATS. Learn more about the NIH SPARC program at https://go.usa.gov/xyFmQ and access SPARC data and tools at sparc.science. Keep up with the latest news by following our YouTube (@sparc.science), Facebook (@NIHCommonFund), and Twitter (@NIH_CommonFund and @sparc_science) accounts.

The SPARC Plug Tools & Tech video series features SPARC-funded research tools and technologies. In our seventh video, learn about a biosensor called Fecobionics that SPARC researchers are developing to help improve therapies for gastrointestinal disorders by providing a reproducible way to assess health and intestinal function. Fecobionics is one of the many tools and technologies being developed by SPARC researchers to help advance therapies that manipulate peripheral nerves and their electrical signals to improve treatment of diseases and conditions such as hypertension, gastrointestinal disorders, type II diabetes, and more. Learn more about SPARC-funded research projects at https://go.usa.gov/xyFmD
The SPARC program is a trans-NIH effort managed by the NIH Common Fund in the Office of the Director and supported by NIBIB, NINDS, NIDDK, and NCATS. Learn more about the NIH SPARC program at https://go.usa.gov/xyFmQ and access SPARC datasets, maps, and more at sparc.science. Keep up with the latest news by following our YouTube (@sparc.science), Facebook (@NIHCommonFund), and Twitter (@NIH_CommonFund and @sparc_science) accounts.

The 4D Nucleome (4DN) Program is exploring the 3D organization of the DNA in the nucleus and how the organization changes over time (the fourth dimension). Exploring the 4D organization of DNA requires developing new tools to observe differences in the organization of DNA between different cells and how the organization in the nucleus of a single cell changes over time. Understanding the dynamic 4D organization of DNA will help researchers determine how changes in nuclear organization affect which genes are turned on and off and how abnormal nuclear organization interrupts cell development and function to cause human disease. The 4DN Program is working to allow the biomedical research community to identify new targets for treatment of human diseases that are caused by abnormal nuclear organization.

The 4DN program is a trans-NIH effort managed by the NIH Common Fund in the Office of the Director and supported by NCI, NIDDK, NIGMS, CSR, NIA, NHGRI, NHLBI, NIAAA, NINDS, NIDA, NIMH, and NIEHS. For more information visit https://commonfund.nih.gov/4dnucleome

The SPARC program is a trans-NIH effort managed by the NIH Common Fund in the Office of the Director and supported by NIBIB, NINDS, NCCIH, NIDDK, and NCATS.

In stage one of the program, SPARC supported the development of new tools and technologies, mapped the connections among a variety of different nerves and organ systems, and created a rich public resource (the SPARC Portal, available at sparc.science, that provides scientists with cutting-edge information and tools for advancing bioelectronic medicine. Building on these accomplishments, in stage two of the program SPARC will focus on the anatomy and functional connectivity of the human vagus nerve (SPARC-V), build a new ecosystem of open-specification neuromodulation device components (SPARC-O), challenge the innovator community to develop targeted therapies (SPARC-X), and will continue to share data and digital resources through the SPARC Portal.

Learn about the NIH SPARC program and what the program is doing to improve public health. For more information, visit our website at https://commonfund.nih.gov/sparc.