We Accelerate Discovery

You are here

Printer

Research Tools

The NIH Nanomedicine Program has supported the production of many research tools with potential uses beyond the Nanomedicine Development Centers’ goals.  Selected, published examples are listed below.

 

Vectors/Constructs

AAV variants that enable the selective targeting of genes to specific neurons, including in the retina of mouse (Caporale et al., 2011) and macaque (Dalkara et al., 2013)

 

Cell cultures and Model Systems

An optimized small molecule inhibitor cocktail for long-term maintenance of human embryonic stem cells, designed by using a feedback system control scheme (Tsutsui et al., 2011).

 

Structural Analyses

Structural mechanistic analayis of TRiC inhibition of mhttQ51 aggregation by cryo-ET (Shahmoradian et al., 2013)

Single-molecule super-resolution imaging and phenotype analysis of Htt-ex1 aggregates in PC12 cells (Sontag et al, 2013)

Definitive TRiC subunit arrangement (Cong et al., 2010; Kalisman et al., 2012) and refined structures of open and closed states based on existing X-ray and cryo-EM data (Pereira et al., 2010)

 

Photoswitches

The first light-gated native GPCRs and demonstration that they regulate synaptic function in brain slice and in vivo (Levitz et al., 2013)

Red-shifted and spontaneously relaxing photoswitches (DENAQ, PhENAQ) (Mourot et al., 2011)

One component system (AAQ) that can restore important aspects of vision to the blind mouse (Polosukhina et al., 2012)

Channelrhodopsin-2 (ChR2) specific to parvalbumin-positive interneurons in the mouse primary visual cortex, used for optogenetic intervention in cortical neural activity (Lee et al., 2012)                          

 

Nanoparticles

Bright and compact quantum dots with broadly tunable adsorption and fluorescence spectra (Smith and Nie, 2011).

Protocells—porous nanoparticle-supported lipid bilayers for targeted delivery of multicomponent cargos to cancer cells (Ashley et al., 2011)

Phi29 DNA-packaging motor for translocation of double-stranded DNA across membranes through nanopores (Wendell et al., 2009)

 

Computational Tools

RosettaBackrub—a web server for flexible backbone protein structure modeling and design (Lauck et al., 2010; https://kortemmelab.ucsf.edu/backrub/cgi-bin/rosettaweb.py?query=index). Exit Disclaimer

MOTIF-EM: an automated computational tool for identifying conserved regions in CryoEM structures (Saha et al., 2010; http://ai.stanford.edu/~mitul/motifEM/). Exit Disclaimer

DREAM4: Combining genetic and dynamic information to identify biological networks and dynamical models (Greenfield et al., 2010; code is publicly available at http://err.bio.nyu.edu/inferelator/). Exit Disclaimer

cMonkey: An algorithm for multi-species integrative biclustering (Waltman et al., 2010; http://ms2.bio.nyu.edu/cMonkey2-trac/). Exit Disclaimer

Up to Top