The Common Fund's Epigenomics Program includes a series of complementary initiatives aimed at generating new research tools, technologies, datasets, and infrastructure to accelerate our understanding of how genome-wide chemical modifications to DNA regulate gene activity without altering the DNA sequence itself and what role these modifications play in health and disease.
Precise Epigenetic Control of Gene Expression Using CRISPR
Uncovering Important Epigenetic Changes in Neuronal Cell Development
Common Fund-Supported Researchers Develop Powerful Tools to Edit Genomes
Common fund-supported researchers map epigenome of more than 100 tissue and cell types
Watch Epigenomics grantee John Stamatoyannopoulos’ lecture “A Roadmap to the Living Genome,” in which he presents research describing new epigenomic maps for a wide variety of normal human cell/tissue types; insights into the genomic patterning of epigenomic features; and encoding of cellular state, maturity, and fate information within epigenomic landscapes.
Watch “A Roadmap to the Living Genome” video here.
Download slides from the Epigenomics presentation to the NIH Council of Councils
Download slides here.
NEW: "Epigenome debut" #10 Top Science Story of 2015.
Science News has ranked the Epigenomics program's "blockbuster effort" of cataloging chemical DNA modifications as the #10 most important science story of 2015. Read the full story here.
NIH Roadmap Epigenomics
Information about the data, protocols, reagents, and analytical tools generated by the Epigenomics Program, including over 100 comprehensive reference epigenomic datasets from hundreds of human cell types and tissues, can be found on the Roadmap Epigenomics Website.
Epigenomes Around the World
The Epigenomics Program is part of the International Human Epigenome Consortium that aims to coordinate worldwide epigenome mapping and characterization efforts.
Tips and Tools for Using Epigenomics Resources
ENCODE/Roadmap Epigenomics Tutorial
Overview of Epigenomics program resources