Funded Research

Rodent Testing Centers for Development of Reporter Systems and Evaluation of Somatic Cell Genome Editing Tools (U42 Clinical Trial Not Allowed) RFA-RM-18-012
PI Name Institution Name Title
HEANEY, JASON D (contact) 
DICKINSON, MARY E 
LAGOR, WILLIAM RAYMOND
BAYLOR COLLEGE OF MEDICINE BCM-Rice resource for the analysis of somatic gene editing in mice
MURRAY, STEPHEN A (contact) 
LUTZ, CATHLEEN M
JACKSON LABORATORY The Jackson Laboratory Gene Editing Testing Center (JAX-GETC)

 

Development of Large Animal Reporter Systems for Testing Somatic Cell Genome Editing Tools (U24 Clinical Trial Not Allowed) RFA-RM-18-013
PI Name Institution Name Title
CARLSON, DANIEL FRED RECOMBINETICS, INC. Development of Swine Reporter Models for Testing Somatic Cell Genome Editing Tools
FENG, GUOPING MASSACHUSETTS INSTITUTE OF TECHNOLOGY Knockin marmoset reporters for non-invasive measuring of genome-editing efficiency
HENNEBOLD, JON D  OREGON HEALTH & SCIENCE UNIVERSITY Rhesus Macaque Somatic Cell Gene Editing Resource

 

Development of Cell and Tissue Platforms to Detect Adverse Biological Consequences of Somatic Cell Gene Editing (U01 Clinical Trial Not Allowed) RFA-RM-18-015
PI Name Institution Name Title
KIANI, SAMIRA ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Multicell type human liver on chip microphysiological platform to examine CRISPR- based gene modulation.
MCDEVITT, TODD C  J. DAVID GLADSTONE INSTITUTES Human microtissues for in situ detection and functional measurement of adverse consequences caused by genome editing
SAHA, KRISHANU (contact) 
GAMM, DAVID M 
ROY, SUSHMITA 
SKALA, MELISSA CAROLINE 
UNIVERSITY OF WISCONSIN-MADISON Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids
TSAI, SHENGDAR  ST. JUDE CHILDREN'S RESEARCH HOSPITAL A novel human T-cell platform to define biological effects of genome editing

 

Innovative Technologies to Deliver Genome Editing Machinery to Disease-relevant Cells and Tissues (UG3/UH3 Clinical Trial Not Allowed) RFA-RM-18-016
PI Name Institution Name Title
ASOKAN, ARAVIND DUKE UNIVERSITY Evolving High Potency AAV Vectors for Neuromuscular Genome Editing
CHEN, ZHENG-YI (contact) 
LIU, DAVID R 
XU, QIAOBING
MASSACHUSETTS EYE AND EAR INFIRMARY Efficient in Vivo RNP-based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid Nanoparticles
DEVERMAN, BENJAMIN E BROAD INSTITUTE, INC. Novel AAVs engineered for efficient and noninvasive cross-species gene editing throughout the central nervous system
GAO, GUANG-PING (contact) 
ANDERSON, DANIEL G 
XUE, WEN 
UNIV OF MASSACHUSETTS MED SCH WORCESTER Develop combinatorial non-viral and viral CRISPR delivery for lung diseases
GHIRAN, IONITA CALIN  BETH ISRAEL DEACONESS MEDICAL CENTER Bioengineered red blood cells as extracellular vesicle-mediated delivery platforms for gene editing machinery
GONG, SHAOQIN (contact) 
EMBORG, MARINA 
LEVINE, JON E 
ROY, SUBHOJIT 
SAHA, KRISHANU
UNIVERSITY OF WISCONSIN-MADISON Enabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the Brain
MCCRAY, PAUL B UNIVERSITY OF IOWA Delivery of CRISPR Ribonucleoproteins to Airway Epithelia Using Novel Amphiphilic Peptides
SALTZMAN, W. MARK (contact) 
GLAZER, PETER M 
YALE UNIVERSITY Poly(amine-co-ester)s for Targeted Delivery In Vivo of Gene Editing Agents to Bone Marrow and Lung
SONTHEIMER, ERIK J (contact) 
KHVOROVA, ANASTASIA 
WATTS, JONATHAN K 
WOLFE, SCOT A 
UNIV OF MASSACHUSETTS MED SCH WORCESTER Enhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and Donors

 

Expanding the Human Genome Engineering Repertoire (U01 Clinical Trial Not Allowed) RFA-RM-18-017
PI Name Institution Name Title
DOUDNA, JENNIFER A (contact) 
BANFIELD, JILLIAN 
UNIVERSITY OF CALIFORNIA BERKELEY Expanding CRISPR-Cas editing technology through exploration of novel Cas proteins and DNA repair systems
EKKER, STEPHEN CARL (contact) 
CLARK, KARL J
MAYO CLINIC ROCHESTER Building the mitochondrial genome editing repertoire
LIU, DAVID R BROAD INSTITUTE, INC. Expanding the Scope of Base Editing

 

This page last reviewed on October 9, 2018