Somatic Cell Genome Editing (SCGE)
Somatic Cell Genome Editing (SCGE)
Funded Research
| PI Name | Institution Name | Title |
|---|---|---|
| AHRENS-NICKLAS, REBECCA CLARE (contact) MUSUNURU, KIRAN | CHILDREN'S HOSP OF PHILADELPHIA | Personalized prime editing as a platform for hepatic inborn errors of metabolism |
| CHEN, ZHENG-YI | MASSACHUSETTS EYE AND EAR INFIRMARY | AAV-mediated editing to treat human autosomal dominant hearing loss DFNA41 and DFNA2 |
| PI Name | Institution Name | Title |
|---|---|---|
| DOUDNA, JENNIFER A | UNIVERSITY OF CALIFORNIA, BERKELEY | Correction of Neurological Disease via Allele Specific Excision of Pathogenic Repeats |
| LUTZ, CATHLEEN M (contact) ARBAB, MANDANA GRAY, STEVEN J LIU, DAVID R MOURO PINTO, RICARDO | JACKSON LABORATORY | Preclinical Genome Editing for Rare Neurological Diseases |
| PERANTEAU, WILLIAM H (contact) MUSUNURU, KIRAN | CHILDREN'S HOSP OF PHILADELPHIA | Postnatal and Prenatal Therapeutic Base Editing for Metabolic Diseases |
| SAHA, KRISHANU | UNIVERSITY OF WISCONSIN-MADISON | The CRISPR Vision Program: Nonviral Genome Editing Platforms to Treat Inherited Retinal Channelopathies |
| VALLABH, SONIA MINIKEL | BROAD INSTITUTE, INC. | Therapeutic editing to lower PrP in prion disease |
| PI Name | Institution Name | Title |
|---|---|---|
| JIANG, YONG-HUI (contact) BERRY-KRAVIS, ELIZABETH MARA ZHOU, JIANGBING | YALE UNIVERSITY | A non-viral CRISPR-mediated genome editing delivery platform as a potential therapy for neurogenetic diseases |
| PI Name | Institution Name | Title |
|---|---|---|
| DWINELL, MELINDA R | MEDICAL COLLEGE OF WISCONSIN | Translational Coordination and Dissemination Center for the SCGE Consortium |
| PI Name | Institution Name | Title |
|---|---|---|
| SHEPPARD, TERRY L. | KEYSTONE SYMPOSIA | Precision Genome Engineering |
| PI Name | Institution Name | Title |
|---|---|---|
| ASOKAN, ARAVIND | DUKE UNIVERSITY | Evolving High Potency AAV Vectors for Neuromuscular Genome Editing. |
| SALTZMAN, W. MARK (contact) GLAZER, PETER M | YALE UNIVERSITY | Poly(amine-co-ester)s for Targeted Delivery In Vivo of Gene Editing Agents to Bone Marrow and Lung |
| PI Name | Institution Name | Title |
|---|---|---|
| JARVIS, THALE CROSS | KEYSTONE SYMPOSIA | Precision Genome Engineering |
| PI Name | Institution Name | Title |
|---|---|---|
| BULTE, JEFF W | JOHNS HOPKINS UNIVERSITY | Non-Invasive Tracking of Genome-Corrected iPS cells in ALS |
| RONALD, JOHN ANDREW | UNIVERSITY OF WESTERN ONTARIO | Non-Invasive Monitoring of CRISPR/Cas-Edited Chimeric Antigen Receptor T (CAR-T) Cells with Reporter Gene-Based Magnetic Resonance Imaging and Positron Emission Tomography |
| TARANTAL, ALICE F (contact) SEGAL, DAVID J | UNIVERSITY OF CALIFORNIA AT DAVIS | Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo |
| VANDSBURGER, MORIEL | UNIVERSITY OF CALIFORNIA BERKELEY | Molecular MRI for in vivo tracking of gene editing and gene edited cells |
| PI Name | Institution Name | Title |
|---|---|---|
| BULTE, JEFF W | JOHNS HOPKINS UNIVERSITY | Non-Invasive Tracking of Genome-Corrected iPS cells in ALS |
| RONALD, JOHN ANDREW | UNIVERSITY OF WESTERN ONTARIO | Non-Invasive Monitoring of CRISPR/Cas-Edited Chimeric Antigen Receptor T (CAR-T) Cells with Reporter Gene-Based Magnetic Resonance Imaging and Positron Emission Tomography |
| TARANTAL, ALICE F (contact) SEGAL, DAVID J | UNIVERSITY OF CALIFORNIA AT DAVIS | Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo |
| VANDSBURGER, MORIEL | UNIVERSITY OF CALIFORNIA BERKELEY | Molecular MRI for in vivo tracking of gene editing and gene edited cells |
| PI Name | Institution Name | Title |
|---|---|---|
| GERSBACH, CHARLES A | DUKE UNIVERSITY | Epigenome Editing Technologies for Treating Diverse Disease |
| GLAZER, PETER M (contact) LY, DANITH H SALTZMAN, W. MARK | YALE UNIVERSITY | PNA Nanoparticles for Gene Editing In Vivo |
| PI Name | Institution Name | Title |
|---|---|---|
| FREEDMAN, BENJAMIN SOLOMON | UNIVERSITY OF WASHINGTON | Improving the Safety of Genome Editing With Human Kidney Organoids |
| GERSBACH, CHARLES A. (contact) BURSAC, NENAD TRUSKEY, GEORGE A | DUKE UNIVERSITY | Microphysiological Human Tissue Systems for Monitoring of Genome Editing Outcomes |
| HINSON, JOHN TRAVIS | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT | Human cardiac microtissues with innate immune sensing to study adverse consequences of genome editing |
| MORIZANE, RYUJI (contact) LEWIS, JENNIFER A. SABBISETTI, VENKATA | MASSACHUSETTS GENERAL HOSPITAL | Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editing |
| PI Name | Institution Name | Title |
|---|---|---|
| TARANTAL, ALICE F (contact) SEGAL, DAVID J | UNIVERSITY OF CALIFORNIA AT DAVIS | Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools |
| WELLS, KEVIN DALE (contact) PRATHER, RANDALL S | UNIVERSITY OF MISSOURI-COLUMBIA | Swine Somatic Cell Genome Editing (SCGE) Center |
| PI Name | Institution Name | Title |
|---|---|---|
| DWINELL, MELINDA R (contact) SHIMOYAMA, MARY E | MEDICAL COLLEGE OF WISCONSIN | Dissemination and Coordinating Center for the SCGE Consortium |
| PI Name | Institution Name | Title |
|---|---|---|
| HEANEY, JASON D (contact) DICKINSON, MARY E LAGOR, WILLIAM RAYMOND | BAYLOR COLLEGE OF MEDICINE | BCM-Rice resource for the analysis of somatic gene editing in mice |
| MURRAY, STEPHEN A (contact) LUTZ, CATHLEEN M | JACKSON LABORATORY | The Jackson Laboratory Gene Editing Testing Center (JAX-GETC) |
| PI Name | Institution Name | Title |
|---|---|---|
| CARLSON, DANIEL FRED | RECOMBINETICS, INC. | Development of Swine Reporter Models for Testing Somatic Cell Genome Editing Tools |
| FENG, GUOPING | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | Knockin marmoset reporters for non-invasive measuring of genome-editing efficiency |
| HENNEBOLD, JON D | OREGON HEALTH & SCIENCE UNIVERSITY | Rhesus Macaque Somatic Cell Gene Editing Resource |
| PI Name | Institution Name | Title |
|---|---|---|
| KIANI, SAMIRA | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | Multicell type human liver on chip microphysiological platform to examine CRISPR- based gene modulation. |
| MCDEVITT, TODD C | J. DAVID GLADSTONE INSTITUTES | Human microtissues for in situ detection and functional measurement of adverse consequences caused by genome editing |
| SAHA, KRISHANU (contact) GAMM, DAVID M ROY, SUSHMITA SKALA, MELISSA CAROLINE | UNIVERSITY OF WISCONSIN-MADISON | Single Cell Profiling To Define Biomarkers Of Photoreceptor Dysfunction After Gene Editing Within PSC-Derived Organoids |
| TSAI, SHENGDAR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL | A novel human T-cell platform to define biological effects of genome editing |
| PI Name | Institution Name | Title |
|---|---|---|
| DOUDNA, JENNIFER A (contact) BANFIELD, JILLIAN | UNIVERSITY OF CALIFORNIA BERKELEY | Expanding CRISPR-Cas editing technology through exploration of novel Cas proteins and DNA repair systems |
| EKKER, STEPHEN CARL (contact) CLARK, KARL J | MAYO CLINIC ROCHESTER | Building the mitochondrial genome editing repertoire |
| LIU, DAVID R | BROAD INSTITUTE, INC. | Expanding the Scope of Base Editing |
