Service Centers & Training

The NIH launched an initiative to increase biomedical scientists’ access to cryo-electron microscopy, by establishing three National Service Centers, through the Transformative High Resolution Cryo-Electron Microscopy program (CryoEM). The awarded CryoEM service centers listed below are constructing new facilities with technologically advanced microscopes, expected to be in service by late 2019. However, some user access programs and training for researchers are currently available at the awarded facilities.

National Center for CryoEM Access & Training (NCCAT):

This advanced service center is located at Simons Electron Microscopy Center at the New York Structural Biology Center. The mission of NCCAT is to provide nationwide access to leading cryo-EM technologies and aid users in developing the cryo-EM skills and expertise required for independent research.

Proposals and Training

User access proposals are currently being accepted. Training applications can also be submitted for NCCAT’s two available training programs. Embedded Training, involves a 3-month intensive immersion experience at NCCAT, focused on supporting scientists to gain the skills to become an independent cryo-EM researcher. Facility Manager Training is open to individuals who will have amplified impact, responsible for managing, leading or training other researchers at their own facilities.

Stanford-SLAC Cryo-EM Center (S2C2):

Located at the Department of Energy’s SLAC National Accelerator laboratory, this cryo-electron microscopy center provides access to cryo-EM instruments for data collection and prepares our nation’s scientists to become independent cryo-EM investigators. The center also offers cryo-specimen preparation devices, data quality assessment tools, and image data storage capacity (short-term basis).

Proposals and Training

This service center is currently accepting user access proposals. Additionally, Short-Format Training is being planned, while In-Residence Training applications are currently being accepted. Established investigators, staff, postdocs or students are eligible. The applications will be considered on a competitive basis for available positions.

The Pacific Northwest Center for Cryo-EM (PNCC):

Pacific Northwest Center for Cryo-EM (PNCC): This state-of-art electron microscopy user facility is operated jointly by Oregon Health and Science University (OHSU) and Pacific Northwest National Laboratory. The mission of the center is to support researchers from a diverse range of backgrounds to tackle challenging scientific problems and train the next generation of cryo-EM users.

Proposals and Training

The center is currently accepting user access proposals from researchers who wish to take advantage of available PNCC cryo-EM equipment. Training programs are in development. Several types of training and cryo-EM educational events are planned, including an Annual Symposium, Intensive Workshops, Personal Trainer Sessions, and Apprenticeships.

You can find a link to our promotional flyer here.

 

CryoEM Educational Resources

Getting Started in Cryo-EM Video Lectures

This comprehensive online cryo-EM curriculum covers theory and practice of major cryo-EM modalities. The curriculum targets: expert users, including PIs teaching cryo-EM in courses, and naïve users. The course will provide additional resources including exam questions, review slides, and more.

CryoEM 101

This online course, currently in development, will have a media-rich curriculum to supplement users’ own hands-on cryoEM training. The material will contain videos, animation and interactive simulations, covering the major components of cryo-EM workflow, from sample purification to image processing.

Virtual Reality Augmented Hands-On Cryo-EM Training

This online course, currently in development, will have a media-rich curriculum to supplement users’ own hands-on cryoEM training. The material will contain videos, animation and interactive simulations, covering the major components of cryo-EM workflow, from sample purification to image processing.

Principles of Cryo-EM Structure Determination

This online curriculum, currently in development, will provide video, software and an e-book to provide the foundations for understanding cryo-EM image processing and reconstruction.

This page last reviewed on June 25, 2019