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Program Snapshot

The Science of Behavior Change (SOBC) program seeks to promote basic research on the initiation, personalization and maintenance of behavior change. By integrating work across disciplines, this effort will lead to an improved understanding of the underlying principles of behavior change. The SOBC Program aims to implement a mechanisms-focused, experimental medicine approach to behavior change research and to develop the tools required to implement such an approach. The experimental medicine approach involves: identifying an intervention target, developing assays (measures) to permit verification of the target, engaging the target through experimentation or intervention, and testing the degree to which target engagement produces the desired behavior change.  Read more...
Want to collaborate with us or have questions? Contact us at SOBCinfo@nih.gov.

Program Highlights

Financial Incentives can Increase the Effectiveness of Smoking Cessation Programs

Financial incentive-based programs can be very effective in helping people to quit smoking. Read more...

Breaking Bad Habits: Summary of a Recent Meeting Hosted by the NIH Common Fund Science of Behavior Change Program


Happiness Examined From the Molecular Level: New Study Findings Reveal a Link Between Well-Being, Health, and Our Genomes



SOBC investigators are holding two workshops in Boston prior to the Association for Psychological Science Annual Convention.

Unhealthy behaviors—such as smoking, drug and alcohol abuse, overeating, and a sedentary lifestyle— contribute to negative health outcomes and common diseases. These types of behaviors account for approximately 40 percent of the risk associated with preventable premature deaths in the United States. Unfortunately, it is extremely difficult to initiate and maintain healthy behavior changes over an extended period of time.

The Common Fund’s Science of Behavior Change (SOBC) program aims to improve our understanding of behavior change across a broad range of health-related behaviors. The program supports research that integrates basic and translational science and cuts across many disciplines. The SOBC program seeks to implement a mechanisms-focused approach to behavior change research and to develop the tools required to implement such an approach. One particular health behavior—adherence to medical regimens—provides particularly compelling test of this approach. Non-adherence to medical regimens is a significant health problem that is an exemplar for the general behavioral intervention goal of initiating and maintaining behavior change.

Stage 1 of the SOBC program sought to improve our understanding of basic mechanisms of human behavior change across a broad array of health-related behaviors and to use this knowledge to develop more effective behavioral interventions.

Research funded during Stage 1 led to the identification of three broad classes of intervention targets that are highly relevant to understanding the mechanisms of behavior change: self-regulationstress reactivity and stress resilience, and interpersonal and social processes

The second stage of the program, the SOBC Research Network, began in fiscal year 2015 and will continue to build on knowledge gained from the first successful stage of the program.

The following institutions were awarded grants to establish the SOBC Research Network:

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