Knockout Mouse Phenotyping Program (KOMP2)
Knockout Mouse Phenotyping Program (KOMP2)
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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.
| Title | Author | Journal Name | PubMedID | Journal Abbreviation | Publication Date | PubMedLink |
|---|---|---|---|---|---|---|
| Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. | Sundberg JP, Shen T, Fiehn O, Rice RH, Silva KA, Kennedy VE, Gott NE, Dionne LA, Bechtold LS, Murray SA, Kuiper R, Pratt CH | PloS one | 30372477 | PLoS One | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30372477 |
| Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. | Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH | PloS one | 28700664 | PLoS One | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/28700664 |
| Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. | Swan AL, Schütt C, Rozman J, Del Mar Muñiz Moreno M, Brandmaier S, Simon M, Leuchtenberger S, Griffiths M, Brommage R, Keskivali-Bond P, Grallert H, Werner T, Teperino R, Becker L, Miller G, Moshiri A, Seavitt JR, Cissell DD, Meehan TF, Acar EF, Lelliott CJ, Flenniken AM, Champy MF, Sorg T, Ayadi A, Braun RE, Cater H, Dickinson ME, Flicek P, Gallegos J, Ghirardello EJ, Heaney JD, Jacquot S, Lally C, Logan JG, Teboul L, Mason J, Spielmann N, McKerlie C, Murray SA, Nutter LMJ, Odfalk KF, Parkinson H, Prochazka J, Reynolds CL, Selloum M, Spoutil F, Svenson KL, Vales TS, Wells SE, White JK, Sedlacek R, Wurst W, Lloyd KCK, Croucher PI, Fuchs H, Williams GR, Bassett JHD, Gailus-Durner V, Herault Y, Mallon AM, Brown SDM, Mayer-Kuckuk P, Hrabe de Angelis M, IMPC Consortium | PLoS genetics | 33370286 | PLoS Genet | 2020 Dec | https://www.ncbi.nlm.nih.gov/pubmed/33370286 |
| Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes. | Wellard SR, Zhang Y, Shults C, Zhao X, McKay M, Murray SA, Jordan PW | EMBO reports | 33615678 | EMBO Rep | 2021 Apr 7 | https://www.ncbi.nlm.nih.gov/pubmed/33615678 |
| APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo. | Snyder EM, McCarty C, Mehalow A, Svenson KL, Murray SA, Korstanje R, Braun RE | RNA (New York, N.Y.) | 28069890 | RNA | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/28069890 |
| Progress towards completing the mutant mouse null resource. | Peterson KA, Murray SA | Mammalian genome : official journal of the International Mammalian Genome Society | 34698892 | Mamm Genome | 2022 Mar | https://www.ncbi.nlm.nih.gov/pubmed/34698892 |
| Generation and characterization of a knockout mouse of an enhancer of EBF3. | Cordova Hurtado E, Wotton JM, Gulka A, Burke C, Ng JK, Bah I, Manuel J, Heins H, Murray SA, Gorkin DU, White JK, Peterson KA, Turner TN | Biology open | 41081394 | Biol Open | 2025 Nov 15 | https://www.ncbi.nlm.nih.gov/pubmed/41081394 |
| A single-cell transcriptional timelapse of mouse embryonic development, from gastrula to pup. | Qiu C, Martin BK, Welsh IC, Daza RM, Le TM, Huang X, Nichols EK, Taylor ML, Fulton O, O'Day DR, Gomes AR, Ilcisin S, Srivatsan S, Deng X, Disteche CM, Noble WS, Hamazaki N, Moens CB, Kimelman D, Cao J, Schier AF, Spielmann M, Murray SA, Trapnell C, Shendure J | bioRxiv : the preprint server for biology | 37066300 | bioRxiv | 2023 Apr 5 | https://www.ncbi.nlm.nih.gov/pubmed/37066300 |
| DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE. | Roy TA, Bubier JA, Dickson PE, Wilcox TD, Ndukum J, Clark JW, Rizzo SJS, Crabbe JC, Denegre JM, Svenson KL, Braun RE, Kumar V, Murray SA, White JK, Philip VM, Chesler EJ | bioRxiv : the preprint server for biology | 37503148 | bioRxiv | 2023 Jul 10 | https://www.ncbi.nlm.nih.gov/pubmed/37503148 |
| Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation. | Elliott KH, Balchand SK, Bonatto Paese CL, Chang CF, Yang Y, Brown KM, Rasicci DT, He H, Thorner K, Chaturvedi P, Murray SA, Chen J, Porollo A, Peterson KA, Brugmann SA | Development (Cambridge, England) | 36971348 | Development | 2023 Apr 15 | https://www.ncbi.nlm.nih.gov/pubmed/36971348 |
| A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans. | Brophy PD, Rasmussen M, Parida M, Bonde G, Darbro BW, Hong X, Clarke JC, Peterson KA, Denegre J, Schneider M, Sussman CR, Sunde L, Lildballe DL, Hertz JM, Cornell RA, Murray SA, Manak JR | Genetics | 28739660 | Genetics | 2017 Sep | https://www.ncbi.nlm.nih.gov/pubmed/28739660 |
| CRIPT exonic deletion and a novel missense mutation in a female with short stature, dysmorphic features, microcephaly, and pigmentary abnormalities. | Leduc MS, Niu Z, Bi W, Zhu W, Miloslavskaya I, Chiang T, Streff H, Seavitt JR, Murray SA, Eng C, Chan A, Yang Y, Lalani SR | American journal of medical genetics. Part A | 27250922 | Am J Med Genet A | 2016 Aug | https://www.ncbi.nlm.nih.gov/pubmed/27250922 |
| Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". | Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M | Nature methods | 29600991 | Nat Methods | 2018 Apr | https://www.ncbi.nlm.nih.gov/pubmed/29600991 |
| A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model. | Wellard SR, Hopkins J, Jordan PW | Journal of visualized experiments : JoVE | 29443055 | J Vis Exp | 2018 Feb 6 | https://www.ncbi.nlm.nih.gov/pubmed/29443055 |
| Mouse mutagenesis and phenotyping to generate models of development and disease. | Gridley T, Murray SA | Current topics in developmental biology | 35461561 | Curr Top Dev Biol | 2022 | https://www.ncbi.nlm.nih.gov/pubmed/35461561 |
| Mendelian gene identification through mouse embryo viability screening. | Cacheiro P, Westerberg CH, Mager J, Dickinson ME, Nutter LMJ, Muñoz-Fuentes V, Hsu CW, Van den Veyver IB, Flenniken AM, McKerlie C, Murray SA, Teboul L, Heaney JD, Lloyd KCK, Lanoue L, Braun RE, White JK, Creighton AK, Laurin V, Guo R, Qu D, Wells S, Cleak J, Bunton-Stasyshyn R, Stewart M, Harrisson J, Mason J, Haseli Mashhadi H, Parkinson H, Mallon AM, International Mouse Phenotyping Consortium, Genomics England Research Consortium, Smedley D | Genome medicine | 36229886 | Genome Med | 2022 Oct 13 | https://www.ncbi.nlm.nih.gov/pubmed/36229886 |
| The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation. | Muñoz-Fuentes V, Cacheiro P, Meehan TF, Aguilar-Pimentel JA, Brown SDM, Flenniken AM, Flicek P, Galli A, Mashhadi HH, Hrabě de Angelis M, Kim JK, Lloyd KCK, McKerlie C, Morgan H, Murray SA, Nutter LMJ, Reilly PT, Seavitt JR, Seong JK, Simon M, Wardle-Jones H, Mallon AM, Smedley D, Parkinson HE, IMPC consortium | Conservation genetics (Print) | 30100824 | Conserv Genet | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30100824 |
| The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities. | Herbert E, Stewart M, Hutchison M, Flenniken AM, Qu D, Nutter LMJ, McKerlie C, Hobson L, Kick B, Lyons B, Wiegand JP, Doty R, Aguilar-Pimentel JA, Hrabe de Angelis M, Dickinson M, Seavitt J, White JK, Scudamore CL, Wells S | PloS one | 32542000 | PLoS One | 2020 | https://www.ncbi.nlm.nih.gov/pubmed/32542000 |
| Robust mouse tracking in complex environments using neural networks. | Geuther BQ, Deats SP, Fox KJ, Murray SA, Braun RE, White JK, Chesler EJ, Lutz CM, Kumar V | Communications biology | 30937403 | Commun Biol | 2019 | https://www.ncbi.nlm.nih.gov/pubmed/30937403 |
| Machine learning-based automated phenotyping of inflammatory nocifensive behavior in mice. | Wotton JM, Peterson E, Anderson L, Murray SA, Braun RE, Chesler EJ, White JK, Kumar V | Molecular pain | 32955381 | Mol Pain | 2020 Jan-Dec | https://www.ncbi.nlm.nih.gov/pubmed/32955381 |
| Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. | Oestereicher MA, Wotton JM, Ayabe S, Bou About G, Cheng TK, Choi JH, Clary D, Dew EM, Elfertak L, Guimond A, Haseli Mashhadi H, Heaney JD, Kelsey L, Keskivali-Bond P, Lopez Gomez F, Marschall S, McFarland M, Meziane H, Munoz Fuentes V, Nam KH, Nichtová Z, Pimm D, Bower L, Prochazka J, Rozman J, Santos L, Stewart M, Tanaka N, Ward CS, Willett AME, Wilson R, Braun RE, Dickinson ME, Flenniken AM, Herault Y, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Sedlacek R, Seong JK, Sorg T, Tamura M, Wells S, Schneltzer E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, White JK, Spielmann N | Mammalian genome : official journal of the International Mammalian Genome Society | 37294348 | Mamm Genome | 2023 Jun | https://www.ncbi.nlm.nih.gov/pubmed/37294348 |
| Soft windowing application to improve analysis of high-throughput phenotyping data. | Haselimashhadi H, Mason JC, Munoz-Fuentes V, López-Gómez F, Babalola K, Acar EF, Kumar V, White J, Flenniken AM, King R, Straiton E, Seavitt JR, Gaspero A, Garza A, Christianson AE, Hsu CW, Reynolds CL, Lanza DG, Lorenzo I, Green JR, Gallegos JJ, Bohat R, Samaco RC, Veeraragavan S, Kim JK, Miller G, Fuchs H, Garrett L, Becker L, Kang YK, Clary D, Cho SY, Tamura M, Tanaka N, Soo KD, Bezginov A, About GB, Champy MF, Vasseur L, Leblanc S, Meziane H, Selloum M, Reilly PT, Spielmann N, Maier H, Gailus-Durner V, Sorg T, Hiroshi M, Yuichi O, Heaney JD, Dickinson ME, Wolfgang W, Tocchini-Valentini GP, Lloyd KCK, McKerlie C, Seong JK, Yann H, de Angelis MH, Brown SDM, Smedley D, Flicek P, Mallon AM, Parkinson H, Meehan TF | Bioinformatics (Oxford, England) | 31591642 | Bioinformatics | 2020 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/31591642 |
| Lethal phenotypes in Mendelian disorders. | Cacheiro P, Lawson S, Van den Veyver IB, Marengo G, Zocche D, Murray SA, Duyzend M, Robinson PN, Smedley D | Genetics in medicine : official journal of the American College of Medical Genetics | 38629401 | Genet Med | 2024 Jul | https://www.ncbi.nlm.nih.gov/pubmed/38629401 |
| Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes. | Vo P, Imai-Leonard DM, Yang B, Briere A, Shao A, Casanova MI, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Braun R, Brown S, Burrill S, Cho SY, Clementson-Mobbs S, D'Souza A, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Angelis MH, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Murray S, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Ryan J, Salazar J, Seavey Z, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Udensi U, Wells S, White J, Willett A, Wotton J, Wurst W, Yoshiki A, International Mouse Phenotyping Consortium, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A | BMC genomics | 39833678 | BMC Genomics | 2025 Jan 20 | https://www.ncbi.nlm.nih.gov/pubmed/39833678 |
| Discovery and validation of genes driving drug-intake and related behavioral traits in mice. | Roy TA, Bubier JA, Dickson PE, Wilcox TD, Ndukum J, Clark JW, Sukoff Rizzo SJ, Crabbe JC, Denegre JM, Svenson KL, Braun RE, Kumar V, Murray SA, White JK, Philip VM, Chesler EJ | Genes, brain, and behavior | 38164795 | Genes Brain Behav | 2024 Jan 2 | https://www.ncbi.nlm.nih.gov/pubmed/38164795 |
| Identifying genetic determinants of outer retinal function in mice using a large-scale gene-targeted screen. | Wotton JM, Krebs MP, Sangermano R, Wong JK, Smith C, Willett AM, Howell D, Jones A, Witmeyer C, Lowy JP, McFarland M, Murray SA, Braun RE, Nishina PM, Pierce EA, Place EM, Bujakowska KM, Peachey NS, White JK | PLoS genetics | 41021661 | PLoS Genet | 2025 Sep | https://www.ncbi.nlm.nih.gov/pubmed/41021661 |
| Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition. | Liu ET, Bolcun-Filas E, Grass DS, Lutz C, Murray S, Shultz L, Rosenthal N | EMBO reports | 28119373 | EMBO Rep | 2017 Feb | https://www.ncbi.nlm.nih.gov/pubmed/28119373 |
| CRISPRtools: a flexible computational platform for performing CRISPR/Cas9 experiments in the mouse. | Peterson KA, Beane GL, Goodwin LO, Kutny PM, Reinholdt LG, Murray SA | Mammalian genome : official journal of the International Mammalian Genome Society | 28280930 | Mamm Genome | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28280930 |
| High-throughput discovery of novel developmental phenotypes. | Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, International Mouse Phenotyping Consortium, Jackson Laboratory, Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), Charles River Laboratories, MRC Harwell, Toronto Centre for Phenogenomics, Wellcome Trust Sanger Institute, RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA | Nature | 27626380 | Nature | 2016 Sep 22 | https://www.ncbi.nlm.nih.gov/pubmed/27626380 |
| SVEP1 plays a crucial role in epidermal differentiation. | Samuelov L, Li Q, Bochner R, Najor NA, Albrecht L, Malchin N, Goldsmith T, Grafi-Cohen M, Vodo D, Fainberg G, Meilik B, Goldberg I, Warshauer E, Rogers T, Edie S, Ishida-Yamamoto A, Burzenski L, Erez N, Murray SA, Irvine AD, Shultz L, Green KJ, Uitto J, Sprecher E, Sarig O | Experimental dermatology | 27892606 | Exp Dermatol | 2017 May | https://www.ncbi.nlm.nih.gov/pubmed/27892606 |
| Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. | Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N, International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D | Nature genetics | 28650483 | Nat Genet | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28650483 |
| Genetic analysis of Pycr1 and Pycr2 in mice. | Stum MG, Tadenev ALD, Seburn KL, Miers KE, Poon PP, McMaster CR, Robinson C, Kane C, Silva KA, Cliften PF, Sundberg JP, Reinholdt LG, John SWM, Burgess RW | Genetics | 33734376 | Genetics | 2021 May 17 | https://www.ncbi.nlm.nih.gov/pubmed/33734376 |
| Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling. | Brown HM, Murray SA, Northrup H, Au KS, Niswander LA | Development (Cambridge, England) | 33214242 | Development | 2020 Nov 19 | https://www.ncbi.nlm.nih.gov/pubmed/33214242 |
| Identification of genes required for eye development by high-throughput screening of mouse knockouts. | Moore BA, Leonard BC, Sebbag L, Edwards SG, Cooper A, Imai DM, Straiton E, Santos L, Reilly C, Griffey SM, Bower L, Clary D, Mason J, Roux MJ, Meziane H, Herault Y, International Mouse Phenotyping Consortium, McKerlie C, Flenniken AM, Nutter LMJ, Berberovic Z, Owen C, Newbigging S, Adissu H, Eskandarian M, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gallegos JJ, Seavitt JR, Heaney JD, Beaudet AL, Dickinson ME, Justice MJ, Philip V, Kumar V, Svenson KL, Braun RE, Wells S, Cater H, Stewart M, Clementson-Mobbs S, Joynson R, Gao X, Suzuki T, Wakana S, Smedley D, Seong JK, Tocchini-Valentini G, Moore M, Fletcher C, Karp N, Ramirez-Solis R, White JK, de Angelis MH, Wurst W, Thomasy SM, Flicek P, Parkinson H, Brown SDM, Meehan TF, Nishina PM, Murray SA, Krebs MP, Mallon AM, Lloyd KCK, Murphy CJ, Moshiri A | Communications biology | 30588515 | Commun Biol | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30588515 |
| Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. | Wotton JM, Peterson E, Flenniken AM, Bains RS, Veeraragavan S, Bower LR, Bubier JA, Parisien M, Bezginov A, Haselimashhadi H, Mason J, Moore MA, Stewart ME, Clary DA, Delbarre DJ, Anderson LC, D'Souza A, Goodwin LO, Harrison ME, Huang Z, Mckay M, Qu D, Santos L, Srinivasan S, Urban R, Vukobradovic I, Ward CS, Willett AM, Braun RE, Brown SDM, Dickinson ME, Heaney JD, Kumar V, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Parkinson H, Seavitt JR, Wells S, Samaco RC, Chesler EJ, Smedley D, Diatchenko L, Baumbauer KM, Young EE, Bonin RP, Mandillo S, White JK, International Mouse Phenotyping Consortium | Pain | 35552317 | Pain | 2022 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/35552317 |
| A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. | Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L, International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM | Nature communications | 29026089 | Nat Commun | 2017 Oct 12 | https://www.ncbi.nlm.nih.gov/pubmed/29026089 |
| Lethal phenotypes in Mendelian disorders. | Cacheiro P, Lawson S, Van den Veyver IB, Marengo G, Zocche D, Murray SA, Duyzend M, Robinson PN, Smedley D | medRxiv : the preprint server for health sciences | 38260283 | medRxiv | 2024 Jan 13 | https://www.ncbi.nlm.nih.gov/pubmed/38260283 |
| Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy. | Spielmann N, Miller G, Oprea TI, Hsu CW, Fobo G, Frishman G, Montrone C, Haseli Mashhadi H, Mason J, Munoz Fuentes V, Leuchtenberger S, Ruepp A, Wagner M, Westphal DS, Wolf C, Görlach A, Sanz-Moreno A, Cho YL, Teperino R, Brandmaier S, Sharma S, Galter IR, Östereicher MA, Zapf L, Mayer-Kuckuk P, Rozman J, Teboul L, Bunton-Stasyshyn RKA, Cater H, Stewart M, Christou S, Westerberg H, Willett AM, Wotton JM, Roper WB, Christiansen AE, Ward CS, Heaney JD, Reynolds CL, Prochazka J, Bower L, Clary D, Selloum M, Bou About G, Wendling O, Jacobs H, Leblanc S, Meziane H, Sorg T, Audain E, Gilly A, Rayner NW, IMPC consortium, Genomics England Research Consortium, Hitz MP, Zeggini E, Wolf E, Sedlacek R, Murray SA, Svenson KL, Braun RE, White JK, Kelsey L, Gao X, Shiroishi T, Xu Y, Seong JK, Mammano F, Tocchini-Valentini GP, Beaudet AL, Meehan TF, Parkinson H, Smedley D, Mallon AM, Wells SE, Grallert H, Wurst W, Marschall S, Fuchs H, Brown SDM, Flenniken AM, Nutter LMJ, McKerlie C, Herault Y, Lloyd KCK, Dickinson ME, Gailus-Durner V, Hrabe de Angelis M | Nature cardiovascular research | 39195995 | Nat Cardiovasc Res | 2022 Feb | https://www.ncbi.nlm.nih.gov/pubmed/39195995 |
| Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age. | Oestereicher MA, Ward CS, Schneltzer E, Marschall S, Fuchs H, Gailus-Durner V, Bou About G, Selloum M, Meziane H, Stewart M, Teboul L, Norris C, Pimm D, Kan M, López Gómez F, Wilson R, Monroy M, Pasha S, Zabrodska E, Prochazka J, Pajuelo Reguera D, Nichtova Z, Herault Y, Wells S, Parkinson H, Heaney JD, Sedlacek R, Gao X, Hrabe de Angelis M, Spielmann N | Frontiers in cardiovascular medicine | 41488462 | Front Cardiovasc Med | 2025 | https://www.ncbi.nlm.nih.gov/pubmed/41488462 |
| A resource of targeted mutant mouse lines for 5,061 genes. | Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y, International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA | Nature genetics | 33833456 | Nat Genet | 2021 Apr | https://www.ncbi.nlm.nih.gov/pubmed/33833456 |
| Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3. | Hurtado EC, Wotton JM, Gulka A, Burke C, Ng JK, Bah I, Manuel J, Heins H, Murray SA, Gorkin DU, White JK, Peterson KA, Turner TN | bioRxiv : the preprint server for biology | 39829799 | bioRxiv | 2025 Jan 10 | https://www.ncbi.nlm.nih.gov/pubmed/39829799 |
| Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines. | Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, Hérault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA, International Mouse Phenotyping Consortium, Murray SA, Heaney JD, Nutter LMJ | Scientific reports | 39349521 | Sci Rep | 2024 Sep 30 | https://www.ncbi.nlm.nih.gov/pubmed/39349521 |
| The Deep Genome Project. | Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM | Genome biology | 32008577 | Genome Biol | 2020 Feb 3 | https://www.ncbi.nlm.nih.gov/pubmed/32008577 |
| Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands. | Farris MH, Texter PA, Mora AA, Wiles MV, Mac Garrigle EF, Klaus SA, Rosfjord K | BMC genomics | 33267773 | BMC Genomics | 2020 Dec 2 | https://www.ncbi.nlm.nih.gov/pubmed/33267773 |
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| Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation. | Chattopadhyay A, Guan P, Majumder S, Kaw K, Zhou Z, Zhang C, Prakash SK, Kaw A, Buja LM, Kwartler CS, Milewicz DM | Arteriosclerosis, thrombosis, and vascular biology | 35708026 | Arterioscler Thromb Vasc Biol | 2022 Aug | https://www.ncbi.nlm.nih.gov/pubmed/35708026 |
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| Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function. | Findlay AS, McKie L, Keighren M, Clementson-Mobbs S, Sanchez-Pulido L, Wells S, Cross SH, Jackson IJ | Scientific reports | 31949211 | Sci Rep | 2020 Jan 16 | https://www.ncbi.nlm.nih.gov/pubmed/31949211 |
| Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling. | Fish JE, Flores Suarez CP, Boudreau E, Herman AM, Gutierrez MC, Gustafson D, DiStefano PV, Cui M, Chen Z, De Ruiz KB, Schexnayder TS, Ward CS, Radovanovic I, Wythe JD | Circulation research | 32552404 | Circ Res | 2020 Aug 28 | https://www.ncbi.nlm.nih.gov/pubmed/32552404 |
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| Vertical transmission of a large calvarial ossification defect due to heterozygous variants of ALX4 and TWIST1. | Walters ME, Lacassie Y, Azamian M, Franciskovich R, Zapata G, Hernandez PP, Liu P, Campbell IM, Bostwick BL, Lalani SR | American journal of medical genetics. Part A | 33369125 | Am J Med Genet A | 2021 Mar | https://www.ncbi.nlm.nih.gov/pubmed/33369125 |
| Rap1 in the VMH regulates glucose homeostasis. | Kaneko K, Lin HY, Fu Y, Saha PK, De la Puente-Gomez AB, Xu Y, Ohinata K, Chen P, Morozov A, Fukuda M | JCI insight | 33974562 | JCI Insight | 2021 Jun 8 | https://www.ncbi.nlm.nih.gov/pubmed/33974562 |
| Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. | Wang X, Song J, Yuan Y, Li L, Abu-Taha I, Heijman J, Sun L, Dobrev S, Kamler M, Xie L, Wehrens XHT, Horrigan FT, Dobrev D, Li N | Circulation research | 37154033 | Circ Res | 2023 Jun 23 | https://www.ncbi.nlm.nih.gov/pubmed/37154033 |
| Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a NO-CCL2-CCR2 pathway. | Ye Q, Jo J, Wang CY, Oh H, Choy TJ, Kim K, D'Alessandro A, Reshetnyak YK, Jung SY, Chen Z, Marrelli SP, Lee HK | bioRxiv : the preprint server for biology | 37066295 | bioRxiv | 2023 Apr 3 | https://www.ncbi.nlm.nih.gov/pubmed/37066295 |
| Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance. | Stroup BM, Li X, Ho S, Zhouyao H, Chen Y, Ani S, Dawson B, Jin Z, Marom R, Jiang MM, Lorenzo I, Rosen D, Lanza D, Aceves N, Koh S, Seavitt JR, Heaney JD, Lee B, Burrage LC | Disease models & mechanisms | 37486182 | Dis Model Mech | 2023 Aug 1 | https://www.ncbi.nlm.nih.gov/pubmed/37486182 |
| The role of Limch1 alternative splicing in skeletal muscle function. | Penna MS, Hu RC, Rodney GG, Cooper TA | Life science alliance | 36977593 | Life Sci Alliance | 2023 Jun | https://www.ncbi.nlm.nih.gov/pubmed/36977593 |
| Repurposing Atovaquone as a Therapeutic against Acute Myeloid Leukemia (AML): Combination with Conventional Chemotherapy Is Feasible and Well Tolerated. | Stevens AM, Schafer ES, Li M, Terrell M, Rashid R, Paek H, Bernhardt MB, Weisnicht A, Smith WT, Keogh NJ, Alozie MC, Oviedo HH, Gonzalez AK, Ilangovan T, Mangubat-Medina A, Wang H, Jo E, Rabik CA, Bocchini C, Hilsenbeck S, Ball ZT, Cooper TM, Redell MS | Cancers | 36831684 | Cancers (Basel) | 2023 Feb 20 | https://www.ncbi.nlm.nih.gov/pubmed/36831684 |
| Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease. | Jones KM, Mangin EN, Reynolds CL, Villanueva LE, Cruz JV, Versteeg L, Keegan B, Kendricks A, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ | Frontiers in cellular and infection microbiology | 36844399 | Front Cell Infect Microbiol | 2023 | https://www.ncbi.nlm.nih.gov/pubmed/36844399 |
| S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. | Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Coll TF, Richards JS | JCI insight | 31265437 | JCI Insight | 2019 Jul 2 | https://www.ncbi.nlm.nih.gov/pubmed/31265437 |
| Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities. | Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL, Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE, Corrochano S, Nolan PM | Disease models & mechanisms | 30692144 | Dis Model Mech | 2019 Feb 22 | https://www.ncbi.nlm.nih.gov/pubmed/30692144 |
| CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. | Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA | Journal of the American Heart Association | 30371314 | J Am Heart Assoc | 2018 Oct 2 | https://www.ncbi.nlm.nih.gov/pubmed/30371314 |
| FAM92A Underlies Nonsyndromic Postaxial Polydactyly in Humans and an Abnormal Limb and Digit Skeletal Phenotype in Mice. | Schrauwen I, Giese AP, Aziz A, Lafont DT, Chakchouk I, Santos-Cortez RLP, Lee K, Acharya A, Khan FS, Ullah A, Nickerson DA, Bamshad MJ, Ali G, Riazuddin S, Ansar M, Ahmad W, Ahmed ZM, Leal SM | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 30395363 | J Bone Miner Res | 2019 Feb | https://www.ncbi.nlm.nih.gov/pubmed/30395363 |
| Rapid and Integrative Discovery of Retina Regulatory Molecules. | Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MA | Cell reports | 30157441 | Cell Rep | 2018 Aug 28 | https://www.ncbi.nlm.nih.gov/pubmed/30157441 |
| Loss of CTRP10 results in female obesity with preserved metabolic health. | Chen F, Sarver DC, Saqib M, Velez LM, Aja S, Seldin MM, Wong GW | bioRxiv : the preprint server for biology | 37961647 | bioRxiv | 2025 Jan 31 | https://www.ncbi.nlm.nih.gov/pubmed/37961647 |
| Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. | Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL | Communications biology | 37709832 | Commun Biol | 2023 Sep 14 | https://www.ncbi.nlm.nih.gov/pubmed/37709832 |
| Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. | Song J, Navarro-Garcia JA, Wu J, Saljic A, Abu-Taha I, Li L, Lahiri SK, Keefe JA, Aguilar-Sanchez Y, Moore OM, Yuan Y, Wang X, Kamler M, Mitch WE, Ruiz-Hurtado G, Hu Z, Thomas SS, Dobrev D, Wehrens XH, Li N | The Journal of clinical investigation | 37581942 | J Clin Invest | 2023 Oct 2 | https://www.ncbi.nlm.nih.gov/pubmed/37581942 |
| Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model. | Nitschke L, Hu RC, Miller AN, Cooper TA | Human molecular genetics | 39126705 | Hum Mol Genet | 2024 Oct 7 | https://www.ncbi.nlm.nih.gov/pubmed/39126705 |
| Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome. | Potter AS, Miyake CY, Gonzaga-Jauregui C, Aguilar-Sanchez Y, Hulsurkar MM, Lahiri SK, Moreira LM, Mehta N, Azamian MS, Lupski JR, Reilly S, Lalani SR, Wehrens XHT | Circulation. Genomic and precision medicine | 38953222 | Circ Genom Precis Med | 2024 Aug | https://www.ncbi.nlm.nih.gov/pubmed/38953222 |
| MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model. | Hu RC, Zhang Y, Nitschke L, Johnson SJ, Hurley AE, Lagor WR, Xia Z, Cooper TA | The Journal of clinical investigation | 39932794 | J Clin Invest | 2025 Feb 11 | https://www.ncbi.nlm.nih.gov/pubmed/39932794 |
| Loss of CTRP10 results in female obesity with preserved metabolic health. | Chen F, Sarver DC, Saqib M, Velez LM, Aja S, Seldin MM, Wong GW | eLife | 40126547 | Elife | 2025 Mar 24 | https://www.ncbi.nlm.nih.gov/pubmed/40126547 |
| Phosphorylation of RYR1 at Ser(2902) decreases Ca(2+) leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke. | Yee RSZ, Lee CS, Chang T, Jung SY, Yousif O, Cavazos C, Colyer J, Van Petegem F, Rodney GG, Hamilton SL | Science signaling | 41056385 | Sci Signal | 2025 Oct 7 | https://www.ncbi.nlm.nih.gov/pubmed/41056385 |
| Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity. | Mehta N, Larson DT, Salaka RJ, Wozney M, Subramani S, Mishra S, Kaur S, Jain A, Chapman ER | bioRxiv : the preprint server for biology | 41278746 | bioRxiv | 2025 Oct 28 | https://www.ncbi.nlm.nih.gov/pubmed/41278746 |
| SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. | Hinton AO Jr, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK | PloS one | 28006821 | PLoS One | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/28006821 |
| Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. | Santiago-Sim T, Burrage LC, Ebstein F, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, Cogné B, Küry S, Besnard T, Isidor B, Bézieau S, Hazart I, Nagakura H, Immken LL, Littlejohn RO, Roeder E, EuroEPINOMICS RES Consortium Autosomal Recessive working group, S. Hande Caglayan, Kara B, Hardies K, Weckhuysen S, May P, Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY, Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg MC, Wells S, Johnson SJ, Teboul L, Eng CM, Yang Y, Kloetzel PM, Heaney JD, Walkiewicz MA | American journal of human genetics | 28343629 | Am J Hum Genet | 2017 Apr 6 | https://www.ncbi.nlm.nih.gov/pubmed/28343629 |
| Three-dimensional microCT imaging of mouse development from early post-implantation to early postnatal stages. | Hsu CW, Wong L, Rasmussen TL, Kalaga S, McElwee ML, Keith LC, Bohat R, Seavitt JR, Beaudet AL, Dickinson ME | Developmental biology | 27671873 | Dev Biol | 2016 Nov 15 | https://www.ncbi.nlm.nih.gov/pubmed/27671873 |
| Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. | Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z | Circulation | 35034472 | Circulation | 2022 Feb 8 | https://www.ncbi.nlm.nih.gov/pubmed/35034472 |
| Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology. | Hoffman K, Liu Z, Hossain E, Bottazzi ME, Hotez PJ, Jones KM, McCall LI | ACS infectious diseases | 33843195 | ACS Infect Dis | 2021 Jun 11 | https://www.ncbi.nlm.nih.gov/pubmed/33843195 |
| TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. | Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C 3rd, Heijnen CJ, Kavelaars A, Tweardy DJ | Biochemical pharmacology | 34274354 | Biochem Pharmacol | 2021 Oct | https://www.ncbi.nlm.nih.gov/pubmed/34274354 |
| REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. | Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z | Nature | 33762728 | Nature | 2021 Apr | https://www.ncbi.nlm.nih.gov/pubmed/33762728 |
| Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. | Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X | Nature communications | 33772019 | Nat Commun | 2021 Mar 26 | https://www.ncbi.nlm.nih.gov/pubmed/33772019 |
| Profound and redundant functions of arcuate neurons in obesity development. | Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel BR, Wu Q, Shu G, Tong Q | Nature metabolism | 32719538 | Nat Metab | 2020 Aug | https://www.ncbi.nlm.nih.gov/pubmed/32719538 |
| XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. | Meng H, Gonzales NM, Lonard DM, Putluri N, Zhu B, Dacso CC, York B, O'Malley BW | Nature communications | 33277471 | Nat Commun | 2020 Dec 4 | https://www.ncbi.nlm.nih.gov/pubmed/33277471 |
| Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. | Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B | Neuron | 32320644 | Neuron | 2020 Jun 17 | https://www.ncbi.nlm.nih.gov/pubmed/32320644 |
| Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. | Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H | Obesity (Silver Spring, Md.) | 31338999 | Obesity (Silver Spring) | 2019 Aug | https://www.ncbi.nlm.nih.gov/pubmed/31338999 |
| Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. | Stevens AM, Xiang M, Heppler LN, Tošić I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA | Blood advances | 31856268 | Blood Adv | 2019 Dec 23 | https://www.ncbi.nlm.nih.gov/pubmed/31856268 |
| Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy. | Hoffman KA, Reynolds C, Bottazzi ME, Hotez P, Jones K | Journal of the American Heart Association | 31718442 | J Am Heart Assoc | 2019 Nov 19 | https://www.ncbi.nlm.nih.gov/pubmed/31718442 |
| The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming. | Rueda EM, Hall BM, Hill MC, Swinton PG, Tong X, Martin JF, Poché RA | Cell reports | 31067451 | Cell Rep | 2019 May 7 | https://www.ncbi.nlm.nih.gov/pubmed/31067451 |
| Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche. | Hu T, Kitano A, Luu V, Dawson B, Hoegenauer KA, Lee BH, Nakada D | Stem cell reports | 31257132 | Stem Cell Reports | 2019 Sep 10 | https://www.ncbi.nlm.nih.gov/pubmed/31257132 |
| Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. | Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, University of Washington Center for Mendelian Genomics, Undiagnosed Diseases Network, Bertola D, Yamamoto GL, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B | American journal of human genetics | 30773277 | Am J Hum Genet | 2019 Mar 7 | https://www.ncbi.nlm.nih.gov/pubmed/30773277 |
| Tead1 is required for perinatal cardiomyocyte proliferation. | Liu R, Jagannathan R, Li F, Lee J, Balasubramanyam N, Kim BS, Yang P, Yechoor VK, Moulik M | PloS one | 30811446 | PLoS One | 2019 | https://www.ncbi.nlm.nih.gov/pubmed/30811446 |
| Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism. | Stork BA, Dean A, Ortiz AR, Saha P, Putluri N, Planas-Silva MD, Mahmud I, Rajapakshe K, Coarfa C, Knapp S, Lorenzi PL, Kemp BE, Turk BE, Scott JW, Means AR, York B | Molecular metabolism | 35562082 | Mol Metab | 2022 Aug | https://www.ncbi.nlm.nih.gov/pubmed/35562082 |
| Methodology for measuring oxidative capacity of isolated peroxisomes in the Seahorse assay. | Stork BA, Dean A, York B | Journal of biological methods | 35733440 | J Biol Methods | 2022 | https://www.ncbi.nlm.nih.gov/pubmed/35733440 |
| Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. | Morriss GR, Rajapakshe K, Huang S, Coarfa C, Cooper TA | Human molecular genetics | 29771332 | Hum Mol Genet | 2018 Aug 15 | https://www.ncbi.nlm.nih.gov/pubmed/29771332 |
| Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. | Lanza DG, Gaspero A, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C, Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, Heaney JD | BMC biology | 29925370 | BMC Biol | 2018 Jun 21 | https://www.ncbi.nlm.nih.gov/pubmed/29925370 |
| Dynamic Imaging of Mouse Embryos and Cardiodynamics in Static Culture. | Lopez AL 3rd, Larina IV | Methods in molecular biology (Clifton, N.J.) | 29564760 | Methods Mol Biol | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29564760 |
| Three-dimensional microCT imaging of mouse heart development from early post-implantation to late fetal stages. | Li-Villarreal N, Rasmussen TL, Christiansen AE, Dickinson ME, Hsu CW | Mammalian genome : official journal of the International Mammalian Genome Society | 36595063 | Mamm Genome | 2023 Jun | https://www.ncbi.nlm.nih.gov/pubmed/36595063 |
| Smooth muscle α-actin missense variant promotes atherosclerosis through modulation of intracellular cholesterol in smooth muscle cells. | Kaw K, Chattopadhyay A, Guan P, Chen J, Majumder S, Duan XY, Ma S, Zhang C, Kwartler CS, Milewicz DM | European heart journal | 37377039 | Eur Heart J | 2023 Aug 1 | https://www.ncbi.nlm.nih.gov/pubmed/37377039 |
| TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system. | Akula SK, Marciano JH, Lim Y, Exposito-Alonso D, Hylton NK, Hwang GH, Neil JE, Dominado N, Bunton-Stasyshyn RK, Song JHT, Talukdar M, Schmid A, Teboul L, Mo A, Shin T, Finander B, Beck SG, Yeh RC, Otani A, Qian X, DeGennaro EM, Alkuraya FS, Maddirevula S, Cascino GD, Giannini C, Undiagnosed Diseases Network, Burrage LC, Rosenfield JA, Ketkar S, Clark GD, Bacino C, Lewis RA, Segal RA, Bazan JF, Smith KA, Golden JA, Cho G, Walsh CA | Proceedings of the National Academy of Sciences of the United States of America | 36669111 | Proc Natl Acad Sci U S A | 2023 Jan 24 | https://www.ncbi.nlm.nih.gov/pubmed/36669111 |
| Dysregulated systemic metabolism in a Down syndrome mouse model. | Sarver DC, Xu C, Velez LM, Aja S, Jaffe AE, Seldin MM, Reeves RH, Wong GW | Molecular metabolism | 36587842 | Mol Metab | 2023 Feb | https://www.ncbi.nlm.nih.gov/pubmed/36587842 |
| Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia. | Moore OM, Aguilar-Sanchez Y, Lahiri SK, Hulsurkar MM, Alberto Navarro-Garcia J, Word TA, Keefe JA, Barazi D, Munivez EM, Moore CT, Parthasarathy V, Davidson J, Lagor WR, Park SH, Bao G, Miyake CY, Wehrens XHT | The journal of cardiovascular aging | 38464671 | J Cardiovasc Aging | 2024 Jan | https://www.ncbi.nlm.nih.gov/pubmed/38464671 |
| Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies. | Lahiri SK, Jin F, Zhou Y, Quick AP, Kramm CF, Wang MC, Wehrens XH | Life science alliance | 38438248 | Life Sci Alliance | 2024 May | https://www.ncbi.nlm.nih.gov/pubmed/38438248 |
| Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation. | Majumder S, Chattopadhyay A, Wright JM, Guan P, Buja LM, Kwartler CS, Milewicz DM | JCI insight | 37937642 | JCI Insight | 2023 Nov 8 | https://www.ncbi.nlm.nih.gov/pubmed/37937642 |
| CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer. | Murthy D, Dutta D, Attri KS, Samanta T, Yang S, Jung KH, Latario SG, Putluri V, Huang S, Putluri N, Park JH, Kaipparettu BA | Cancer letters | 38373689 | Cancer Lett | 2024 Apr 10 | https://www.ncbi.nlm.nih.gov/pubmed/38373689 |
| Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout. | Bai Y, Bentley L, Ma C, Naveenan N, Cleak J, Wu Y, Simon MM, Westerberg H, Cañas RC, Horner N, Pandey R, Paphiti K, Schulze U, Mianné J, Hough T, Teboul L, de Baaij JHF, Cox RD | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 37773757 | FASEB J | 2023 Nov | https://www.ncbi.nlm.nih.gov/pubmed/37773757 |
| Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice. | Liu J, Xiao F, Choubey A, Kumar S U, Wang Y, Hong S, Yang T, Otlu HG, Oturmaz ES, Loro E, Sun Y, Saha P, Khurana TS, Chen L, Hou X, Sun Z | Nature communications | 40593528 | Nat Commun | 2025 Jul 1 | https://www.ncbi.nlm.nih.gov/pubmed/40593528 |
| Machine learning in time-lapse imaging to differentiate embryos from young vs old mice†. | Yang L, Leynes C, Pawelka A, Lorenzo I, Chou A, Lee B, Heaney JD | Biology of reproduction | 38685607 | Biol Reprod | 2024 Jun 12 | https://www.ncbi.nlm.nih.gov/pubmed/38685607 |
| MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation. | Armstrong D, Chang CY, Hong MJ, Green L, Shen Y, Hudson W, Mauk KE, Song LZ, Jammi S, Casal B, Burns B, Creighton CJ, Carisey A, Zhang XH, McKenna NJ, Kang SW, Lee HS, Decker W, Corry DB, Kheradmand F | Science advances | 39937892 | Sci Adv | 2025 Feb 14 | https://www.ncbi.nlm.nih.gov/pubmed/39937892 |
| YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity. | Tsai CR, Liu L, Zhao Y, Kim JH, Czarnewski P, Li RG, Meng F, Zheng M, Steimle J, Zhao X, Grisanti F, Sun Z, Wang J, Samee MAH, Li X, Martin JF | Circulation research | 41165345 | Circ Res | 2025 Dec 5 | https://www.ncbi.nlm.nih.gov/pubmed/41165345 |
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| A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). | Carofino BL, Ayanga B, Justice MJ | Disease models & mechanisms | 24046360 | Dis Model Mech | 2013 Nov | https://www.ncbi.nlm.nih.gov/pubmed/24046360 |
| Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice. | Menon RT, Shrestha AK, Barrios R, Reynolds C, Shivanna B | International journal of molecular sciences | 32244398 | Int J Mol Sci | 2020 Mar 31 | https://www.ncbi.nlm.nih.gov/pubmed/32244398 |
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| Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies. | Talwar C, Davuluri GVN, Kamal AHM, Coarfa C, Han SJ, Veeraragavan S, Parsawar K, Putluri N, Hoffman K, Jimenez P, Biest S, Kommagani R | Med (New York, N.Y.) | 39395412 | Med | 2025 Feb 14 | https://www.ncbi.nlm.nih.gov/pubmed/39395412 |
| Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. | Morikawa Y, Zhang M, Heallen T, Leach J, Tao G, Xiao Y, Bai Y, Li W, Willerson JT, Martin JF | Science signaling | 25943351 | Sci Signal | 2015 May 5 | https://www.ncbi.nlm.nih.gov/pubmed/25943351 |
| Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography: a comparison study. | Han Z, Li J, Singh M, Wu C, Liu CH, Wang S, Idugboe R, Raghunathan R, Sudheendran N, Aglyamov SR, Twa MD, Larin KV | Physics in medicine and biology | 25860076 | Phys Med Biol | 2015 May 7 | https://www.ncbi.nlm.nih.gov/pubmed/25860076 |
| Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. | McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB | Frontiers in physiology | 26379556 | Front Physiol | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26379556 |
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| Analysis of the effects of curvature and thickness on elastic wave velocity in cornea-like structures by finite element modeling and optical coherence elastography. | Han Z, Li J, Singh M, Aglyamov SR, Wu C, Liu CH, Larin KV | Applied physics letters | 26130825 | Appl Phys Lett | 2015 Jun 8 | https://www.ncbi.nlm.nih.gov/pubmed/26130825 |
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| Yap and Taz play a crucial role in neural crest-derived craniofacial development. | Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF | Development (Cambridge, England) | 26718006 | Development | 2016 Feb 1 | https://www.ncbi.nlm.nih.gov/pubmed/26718006 |
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