Knockout Mouse Phenotyping Program (KOMP2)
Knockout Mouse Phenotyping Program (KOMP2)
Program Publications
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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.
| Title | Author | Journal Name | PubMedID | Journal Abbreviation | Publication Date | PubMedLink |
|---|---|---|---|---|---|---|
| Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation. | Elliott KH, Balchand SK, Bonatto Paese CL, Chang CF, Yang Y, Brown KM, Rasicci DT, He H, Thorner K, Chaturvedi P, Murray SA, Chen J, Porollo A, Peterson KA, Brugmann SA | Development (Cambridge, England) | 36971348 | Development | 2023 Apr 15 | https://www.ncbi.nlm.nih.gov/pubmed/36971348 |
| SVEP1 plays a crucial role in epidermal differentiation. | Samuelov L, Li Q, Bochner R, Najor NA, Albrecht L, Malchin N, Goldsmith T, Grafi-Cohen M, Vodo D, Fainberg G, Meilik B, Goldberg I, Warshauer E, Rogers T, Edie S, Ishida-Yamamoto A, Burzenski L, Erez N, Murray SA, Irvine AD, Shultz L, Green KJ, Uitto J, Sprecher E, Sarig O | Experimental dermatology | 27892606 | Exp Dermatol | 2017 May | https://www.ncbi.nlm.nih.gov/pubmed/27892606 |
| APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo. | Snyder EM, McCarty C, Mehalow A, Svenson KL, Murray SA, Korstanje R, Braun RE | RNA (New York, N.Y.) | 28069890 | RNA | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/28069890 |
| Identification of genes required for eye development by high-throughput screening of mouse knockouts. | Moore BA, Leonard BC, Sebbag L, Edwards SG, Cooper A, Imai DM, Straiton E, Santos L, Reilly C, Griffey SM, Bower L, Clary D, Mason J, Roux MJ, Meziane H, Herault Y, International Mouse Phenotyping Consortium, McKerlie C, Flenniken AM, Nutter LMJ, Berberovic Z, Owen C, Newbigging S, Adissu H, Eskandarian M, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gallegos JJ, Seavitt JR, Heaney JD, Beaudet AL, Dickinson ME, Justice MJ, Philip V, Kumar V, Svenson KL, Braun RE, Wells S, Cater H, Stewart M, Clementson-Mobbs S, Joynson R, Gao X, Suzuki T, Wakana S, Smedley D, Seong JK, Tocchini-Valentini G, Moore M, Fletcher C, Karp N, Ramirez-Solis R, White JK, de Angelis MH, Wurst W, Thomasy SM, Flicek P, Parkinson H, Brown SDM, Meehan TF, Nishina PM, Murray SA, Krebs MP, Mallon AM, Lloyd KCK, Murphy CJ, Moshiri A | Communications biology | 30588515 | Commun Biol | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30588515 |
| Prevalence of sexual dimorphism in mammalian phenotypic traits. | Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL, International Mouse Phenotyping Consortium, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK | Nature communications | 28650954 | Nat Commun | 2017 Jun 26 | https://www.ncbi.nlm.nih.gov/pubmed/28650954 |
| Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. | Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH | PloS one | 28700664 | PLoS One | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/28700664 |
| Lethal phenotypes in Mendelian disorders. | Cacheiro P, Lawson S, Van den Veyver IB, Marengo G, Zocche D, Murray SA, Duyzend M, Robinson PN, Smedley D | medRxiv : the preprint server for health sciences | 38260283 | medRxiv | 2024 Jan 13 | https://www.ncbi.nlm.nih.gov/pubmed/38260283 |
| Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling. | Brown HM, Murray SA, Northrup H, Au KS, Niswander LA | Development (Cambridge, England) | 33214242 | Development | 2020 Nov 19 | https://www.ncbi.nlm.nih.gov/pubmed/33214242 |
| Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes. | Wellard SR, Zhang Y, Shults C, Zhao X, McKay M, Murray SA, Jordan PW | EMBO reports | 33615678 | EMBO Rep | 2021 Apr 7 | https://www.ncbi.nlm.nih.gov/pubmed/33615678 |
| Genetic analysis of Pycr1 and Pycr2 in mice. | Stum MG, Tadenev ALD, Seburn KL, Miers KE, Poon PP, McMaster CR, Robinson C, Kane C, Silva KA, Cliften PF, Sundberg JP, Reinholdt LG, John SWM, Burgess RW | Genetics | 33734376 | Genetics | 2021 May 17 | https://www.ncbi.nlm.nih.gov/pubmed/33734376 |
| A single-cell time-lapse of mouse prenatal development from gastrula to birth. | Qiu C, Martin BK, Welsh IC, Daza RM, Le TM, Huang X, Nichols EK, Taylor ML, Fulton O, O'Day DR, Gomes AR, Ilcisin S, Srivatsan S, Deng X, Disteche CM, Noble WS, Hamazaki N, Moens CB, Kimelman D, Cao J, Schier AF, Spielmann M, Murray SA, Trapnell C, Shendure J | Nature | 38355799 | Nature | 2024 Feb | https://www.ncbi.nlm.nih.gov/pubmed/38355799 |
| The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation. | Muñoz-Fuentes V, Cacheiro P, Meehan TF, Aguilar-Pimentel JA, Brown SDM, Flenniken AM, Flicek P, Galli A, Mashhadi HH, Hrabě de Angelis M, Kim JK, Lloyd KCK, McKerlie C, Morgan H, Murray SA, Nutter LMJ, Reilly PT, Seavitt JR, Seong JK, Simon M, Wardle-Jones H, Mallon AM, Smedley D, Parkinson HE, IMPC consortium | Conservation genetics (Print) | 30100824 | Conserv Genet | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30100824 |
| A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model. | Wellard SR, Hopkins J, Jordan PW | Journal of visualized experiments : JoVE | 29443055 | J Vis Exp | 2018 Feb 6 | https://www.ncbi.nlm.nih.gov/pubmed/29443055 |
| A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. | Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L, International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM | Nature communications | 29026089 | Nat Commun | 2017 Oct 12 | https://www.ncbi.nlm.nih.gov/pubmed/29026089 |
| The Deep Genome Project. | Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM | Genome biology | 32008577 | Genome Biol | 2020 Feb 3 | https://www.ncbi.nlm.nih.gov/pubmed/32008577 |
| CRIPT exonic deletion and a novel missense mutation in a female with short stature, dysmorphic features, microcephaly, and pigmentary abnormalities. | Leduc MS, Niu Z, Bi W, Zhu W, Miloslavskaya I, Chiang T, Streff H, Seavitt JR, Murray SA, Eng C, Chan A, Yang Y, Lalani SR | American journal of medical genetics. Part A | 27250922 | Am J Med Genet A | 2016 Aug | https://www.ncbi.nlm.nih.gov/pubmed/27250922 |
| Robust mouse tracking in complex environments using neural networks. | Geuther BQ, Deats SP, Fox KJ, Murray SA, Braun RE, White JK, Chesler EJ, Lutz CM, Kumar V | Communications biology | 30937403 | Commun Biol | 2019 | https://www.ncbi.nlm.nih.gov/pubmed/30937403 |
| Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis. | Goodwin LO, Splinter E, Davis TL, Urban R, He H, Braun RE, Chesler EJ, Kumar V, van Min M, Ndukum J, Philip VM, Reinholdt LG, Svenson K, White JK, Sasner M, Lutz C, Murray SA | Genome research | 30659012 | Genome Res | 2019 Mar | https://www.ncbi.nlm.nih.gov/pubmed/30659012 |
| Mouse mutagenesis and phenotyping to generate models of development and disease. | Gridley T, Murray SA | Current topics in developmental biology | 35461561 | Curr Top Dev Biol | 2022 | https://www.ncbi.nlm.nih.gov/pubmed/35461561 |
| Identification of genetic elements in metabolism by high-throughput mouse phenotyping. | Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H, IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M | Nature communications | 29348434 | Nat Commun | 2018 Jan 18 | https://www.ncbi.nlm.nih.gov/pubmed/29348434 |
| Mendelian gene identification through mouse embryo viability screening. | Cacheiro P, Westerberg CH, Mager J, Dickinson ME, Nutter LMJ, Muñoz-Fuentes V, Hsu CW, Van den Veyver IB, Flenniken AM, McKerlie C, Murray SA, Teboul L, Heaney JD, Lloyd KCK, Lanoue L, Braun RE, White JK, Creighton AK, Laurin V, Guo R, Qu D, Wells S, Cleak J, Bunton-Stasyshyn R, Stewart M, Harrisson J, Mason J, Haseli Mashhadi H, Parkinson H, Mallon AM, International Mouse Phenotyping Consortium, Genomics England Research Consortium, Smedley D | Genome medicine | 36229886 | Genome Med | 2022 Oct 13 | https://www.ncbi.nlm.nih.gov/pubmed/36229886 |
| Discovery and validation of genes driving drug-intake and related behavioral traits in mice. | Roy TA, Bubier JA, Dickson PE, Wilcox TD, Ndukum J, Clark JW, Sukoff Rizzo SJ, Crabbe JC, Denegre JM, Svenson KL, Braun RE, Kumar V, Murray SA, White JK, Philip VM, Chesler EJ | Genes, brain, and behavior | 38164795 | Genes Brain Behav | 2024 Jan 2 | https://www.ncbi.nlm.nih.gov/pubmed/38164795 |
| A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans. | Brophy PD, Rasmussen M, Parida M, Bonde G, Darbro BW, Hong X, Clarke JC, Peterson KA, Denegre J, Schneider M, Sussman CR, Sunde L, Lildballe DL, Hertz JM, Cornell RA, Murray SA, Manak JR | Genetics | 28739660 | Genetics | 2017 Sep | https://www.ncbi.nlm.nih.gov/pubmed/28739660 |
| Soft windowing application to improve analysis of high-throughput phenotyping data. | Haselimashhadi H, Mason JC, Munoz-Fuentes V, López-Gómez F, Babalola K, Acar EF, Kumar V, White J, Flenniken AM, King R, Straiton E, Seavitt JR, Gaspero A, Garza A, Christianson AE, Hsu CW, Reynolds CL, Lanza DG, Lorenzo I, Green JR, Gallegos JJ, Bohat R, Samaco RC, Veeraragavan S, Kim JK, Miller G, Fuchs H, Garrett L, Becker L, Kang YK, Clary D, Cho SY, Tamura M, Tanaka N, Soo KD, Bezginov A, About GB, Champy MF, Vasseur L, Leblanc S, Meziane H, Selloum M, Reilly PT, Spielmann N, Maier H, Gailus-Durner V, Sorg T, Hiroshi M, Yuichi O, Heaney JD, Dickinson ME, Wolfgang W, Tocchini-Valentini GP, Lloyd KCK, McKerlie C, Seong JK, Yann H, de Angelis MH, Brown SDM, Smedley D, Flicek P, Mallon AM, Parkinson H, Meehan TF | Bioinformatics (Oxford, England) | 31591642 | Bioinformatics | 2020 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/31591642 |
| High-throughput discovery of novel developmental phenotypes. | Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, International Mouse Phenotyping Consortium, Jackson Laboratory, Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), Charles River Laboratories, MRC Harwell, Toronto Centre for Phenogenomics, Wellcome Trust Sanger Institute, RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA | Nature | 27626380 | Nature | 2016 Sep 22 | https://www.ncbi.nlm.nih.gov/pubmed/27626380 |
| Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". | Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M | Nature methods | 29600991 | Nat Methods | 2018 Apr | https://www.ncbi.nlm.nih.gov/pubmed/29600991 |
| Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. | Oestereicher MA, Wotton JM, Ayabe S, Bou About G, Cheng TK, Choi JH, Clary D, Dew EM, Elfertak L, Guimond A, Haseli Mashhadi H, Heaney JD, Kelsey L, Keskivali-Bond P, Lopez Gomez F, Marschall S, McFarland M, Meziane H, Munoz Fuentes V, Nam KH, Nichtová Z, Pimm D, Bower L, Prochazka J, Rozman J, Santos L, Stewart M, Tanaka N, Ward CS, Willett AME, Wilson R, Braun RE, Dickinson ME, Flenniken AM, Herault Y, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Sedlacek R, Seong JK, Sorg T, Tamura M, Wells S, Schneltzer E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, White JK, Spielmann N | Mammalian genome : official journal of the International Mammalian Genome Society | 37294348 | Mamm Genome | 2023 Jun | https://www.ncbi.nlm.nih.gov/pubmed/37294348 |
| Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. | Wotton JM, Peterson E, Flenniken AM, Bains RS, Veeraragavan S, Bower LR, Bubier JA, Parisien M, Bezginov A, Haselimashhadi H, Mason J, Moore MA, Stewart ME, Clary DA, Delbarre DJ, Anderson LC, D'Souza A, Goodwin LO, Harrison ME, Huang Z, Mckay M, Qu D, Santos L, Srinivasan S, Urban R, Vukobradovic I, Ward CS, Willett AM, Braun RE, Brown SDM, Dickinson ME, Heaney JD, Kumar V, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Parkinson H, Seavitt JR, Wells S, Samaco RC, Chesler EJ, Smedley D, Diatchenko L, Baumbauer KM, Young EE, Bonin RP, Mandillo S, White JK, International Mouse Phenotyping Consortium | Pain | 35552317 | Pain | 2022 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/35552317 |
| A single-cell transcriptional timelapse of mouse embryonic development, from gastrula to pup. | Qiu C, Martin BK, Welsh IC, Daza RM, Le TM, Huang X, Nichols EK, Taylor ML, Fulton O, O'Day DR, Gomes AR, Ilcisin S, Srivatsan S, Deng X, Disteche CM, Noble WS, Hamazaki N, Moens CB, Kimelman D, Cao J, Schier AF, Spielmann M, Murray SA, Trapnell C, Shendure J | bioRxiv : the preprint server for biology | 37066300 | bioRxiv | 2023 Apr 5 | https://www.ncbi.nlm.nih.gov/pubmed/37066300 |
| Lethal phenotypes in Mendelian disorders. | Cacheiro P, Lawson S, Van den Veyver IB, Marengo G, Zocche D, Murray SA, Duyzend M, Robinson PN, Smedley D | Genetics in medicine : official journal of the American College of Medical Genetics | 38629401 | Genet Med | 2024 Jul | https://www.ncbi.nlm.nih.gov/pubmed/38629401 |
| Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines. | Elrick H, Peterson KA, Willis BJ, Lanza DG, Acar EF, Ryder EJ, Teboul L, Kasparek P, Birling MC, Adams DJ, Bradley A, Braun RE, Brown SD, Caulder A, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Duddy G, Gertsenstein M, Goodwin LO, Hérault Y, Lintott LG, Lloyd KCK, Lorenzo I, Mackenzie M, Mallon AM, McKerlie C, Parkinson H, Ramirez-Solis R, Seavitt JR, Sedlacek R, Skarnes WC, Smedley D, Wells S, White JK, Wood JA, International Mouse Phenotyping Consortium, Murray SA, Heaney JD, Nutter LMJ | Scientific reports | 39349521 | Sci Rep | 2024 Sep 30 | https://www.ncbi.nlm.nih.gov/pubmed/39349521 |
| Phenotyping first-generation genome editing mutants: a new standard? | Teboul L, Murray SA, Nolan PM | Mammalian genome : official journal of the International Mammalian Genome Society | 28756587 | Mamm Genome | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28756587 |
| Machine learning-based automated phenotyping of inflammatory nocifensive behavior in mice. | Wotton JM, Peterson E, Anderson L, Murray SA, Braun RE, Chesler EJ, White JK, Kumar V | Molecular pain | 32955381 | Mol Pain | 2020 Jan-Dec | https://www.ncbi.nlm.nih.gov/pubmed/32955381 |
| Progress towards completing the mutant mouse null resource. | Peterson KA, Murray SA | Mammalian genome : official journal of the International Mammalian Genome Society | 34698892 | Mamm Genome | 2022 Mar | https://www.ncbi.nlm.nih.gov/pubmed/34698892 |
| A resource of targeted mutant mouse lines for 5,061 genes. | Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y, International Mouse Phenotyping Consortium (IMPC), Teboul L, Murray SA | Nature genetics | 33833456 | Nat Genet | 2021 Apr | https://www.ncbi.nlm.nih.gov/pubmed/33833456 |
| Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. | Sundberg JP, Shen T, Fiehn O, Rice RH, Silva KA, Kennedy VE, Gott NE, Dionne LA, Bechtold LS, Murray SA, Kuiper R, Pratt CH | PloS one | 30372477 | PLoS One | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30372477 |
| Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. | Swan AL, Schütt C, Rozman J, Del Mar Muñiz Moreno M, Brandmaier S, Simon M, Leuchtenberger S, Griffiths M, Brommage R, Keskivali-Bond P, Grallert H, Werner T, Teperino R, Becker L, Miller G, Moshiri A, Seavitt JR, Cissell DD, Meehan TF, Acar EF, Lelliott CJ, Flenniken AM, Champy MF, Sorg T, Ayadi A, Braun RE, Cater H, Dickinson ME, Flicek P, Gallegos J, Ghirardello EJ, Heaney JD, Jacquot S, Lally C, Logan JG, Teboul L, Mason J, Spielmann N, McKerlie C, Murray SA, Nutter LMJ, Odfalk KF, Parkinson H, Prochazka J, Reynolds CL, Selloum M, Spoutil F, Svenson KL, Vales TS, Wells SE, White JK, Sedlacek R, Wurst W, Lloyd KCK, Croucher PI, Fuchs H, Williams GR, Bassett JHD, Gailus-Durner V, Herault Y, Mallon AM, Brown SDM, Mayer-Kuckuk P, Hrabe de Angelis M, IMPC Consortium | PLoS genetics | 33370286 | PLoS Genet | 2020 Dec | https://www.ncbi.nlm.nih.gov/pubmed/33370286 |
| Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands. | Farris MH, Texter PA, Mora AA, Wiles MV, Mac Garrigle EF, Klaus SA, Rosfjord K | BMC genomics | 33267773 | BMC Genomics | 2020 Dec 2 | https://www.ncbi.nlm.nih.gov/pubmed/33267773 |
| CRISPRtools: a flexible computational platform for performing CRISPR/Cas9 experiments in the mouse. | Peterson KA, Beane GL, Goodwin LO, Kutny PM, Reinholdt LG, Murray SA | Mammalian genome : official journal of the International Mammalian Genome Society | 28280930 | Mamm Genome | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28280930 |
| Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. | Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N, International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D | Nature genetics | 28650483 | Nat Genet | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28650483 |
| Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition. | Liu ET, Bolcun-Filas E, Grass DS, Lutz C, Murray S, Shultz L, Rosenthal N | EMBO reports | 28119373 | EMBO Rep | 2017 Feb | https://www.ncbi.nlm.nih.gov/pubmed/28119373 |
| Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3. | Hurtado EC, Wotton JM, Gulka A, Burke C, Ng JK, Bah I, Manuel J, Heins H, Murray SA, Gorkin DU, White JK, Peterson KA, Turner TN | bioRxiv : the preprint server for biology | 39829799 | bioRxiv | 2025 Jan 10 | https://www.ncbi.nlm.nih.gov/pubmed/39829799 |
| Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy. | Spielmann N, Miller G, Oprea TI, Hsu CW, Fobo G, Frishman G, Montrone C, Haseli Mashhadi H, Mason J, Munoz Fuentes V, Leuchtenberger S, Ruepp A, Wagner M, Westphal DS, Wolf C, Görlach A, Sanz-Moreno A, Cho YL, Teperino R, Brandmaier S, Sharma S, Galter IR, Östereicher MA, Zapf L, Mayer-Kuckuk P, Rozman J, Teboul L, Bunton-Stasyshyn RKA, Cater H, Stewart M, Christou S, Westerberg H, Willett AM, Wotton JM, Roper WB, Christiansen AE, Ward CS, Heaney JD, Reynolds CL, Prochazka J, Bower L, Clary D, Selloum M, Bou About G, Wendling O, Jacobs H, Leblanc S, Meziane H, Sorg T, Audain E, Gilly A, Rayner NW, IMPC consortium, Genomics England Research Consortium, Hitz MP, Zeggini E, Wolf E, Sedlacek R, Murray SA, Svenson KL, Braun RE, White JK, Kelsey L, Gao X, Shiroishi T, Xu Y, Seong JK, Mammano F, Tocchini-Valentini GP, Beaudet AL, Meehan TF, Parkinson H, Smedley D, Mallon AM, Wells SE, Grallert H, Wurst W, Marschall S, Fuchs H, Brown SDM, Flenniken AM, Nutter LMJ, McKerlie C, Herault Y, Lloyd KCK, Dickinson ME, Gailus-Durner V, Hrabe de Angelis M | Nature cardiovascular research | 39195995 | Nat Cardiovasc Res | 2022 Feb | https://www.ncbi.nlm.nih.gov/pubmed/39195995 |
| Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity. | Peterson KA, Khalouei S, Hanafi N, Wood JA, Lanza DG, Lintott LG, Willis BJ, Seavitt JR, Braun RE, Dickinson ME, White JK, Lloyd KCK, Heaney JD, Murray SA, Ramani A, Nutter LMJ | Communications biology | 37301944 | Commun Biol | 2023 Jun 10 | https://www.ncbi.nlm.nih.gov/pubmed/37301944 |
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| Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications. | Zajitschek SR, Zajitschek F, Bonduriansky R, Brooks RC, Cornwell W, Falster DS, Lagisz M, Mason J, Senior AM, Noble DW, Nakagawa S | eLife | 33198888 | Elife | 2020 Nov 17 | https://www.ncbi.nlm.nih.gov/pubmed/33198888 |
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| Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes. | Lana-Elola E, Cater H, Watson-Scales S, Greenaway S, Müller-Winkler J, Gibbins D, Nemes M, Slender A, Hough T, Keskivali-Bond P, Scudamore CL, Herbert E, Banks GT, Mobbs H, Canonica T, Tosh J, Noy S, Llorian M, Nolan PM, Griffin JL, Good M, Simon M, Mallon AM, Wells S, Fisher EMC, Tybulewicz VLJ | Disease models & mechanisms | 34477842 | Dis Model Mech | 2021 Oct 1 | https://www.ncbi.nlm.nih.gov/pubmed/34477842 |
| Phenotype-aware prioritisation of rare Mendelian disease variants. | Kelly C, Szabo A, Pontikos N, Arno G, Robinson PN, Jacobsen JOB, Smedley D, Cipriani V | Trends in genetics : TIG | 35934592 | Trends Genet | 2022 Dec | https://www.ncbi.nlm.nih.gov/pubmed/35934592 |
| Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males. | Wilson LAB, Zajitschek SRK, Lagisz M, Mason J, Haselimashhadi H, Nakagawa S | Nature communications | 36509767 | Nat Commun | 2022 Dec 12 | https://www.ncbi.nlm.nih.gov/pubmed/36509767 |
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| Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function. | Findlay AS, McKie L, Keighren M, Clementson-Mobbs S, Sanchez-Pulido L, Wells S, Cross SH, Jackson IJ | Scientific reports | 31949211 | Sci Rep | 2020 Jan 16 | https://www.ncbi.nlm.nih.gov/pubmed/31949211 |
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| Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation. | Chattopadhyay A, Guan P, Majumder S, Kaw K, Zhou Z, Zhang C, Prakash SK, Kaw A, Buja LM, Kwartler CS, Milewicz DM | Arteriosclerosis, thrombosis, and vascular biology | 35708026 | Arterioscler Thromb Vasc Biol | 2022 Aug | https://www.ncbi.nlm.nih.gov/pubmed/35708026 |
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| A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis. | Wang Y, Zhu D, Ortiz-Velez LC, Perry JL, Pennington MW, Hyser JM, Britton RA, Beeton C | Proceedings of the National Academy of Sciences of the United States of America | 36595694 | Proc Natl Acad Sci U S A | 2023 Jan 10 | https://www.ncbi.nlm.nih.gov/pubmed/36595694 |
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| Clinical exome sequencing uncovers genetic disorders in neonates with suspected hypoxic-ischemic encephalopathy: A retrospective analysis. | Parobek CM, Zemet R, Shanahan MA, Burnett BA, Mizerik E, Rosenfeld JA, Vossaert L, Clark SL, Hunter JV, Lalani SR | Clinical genetics | 38545656 | Clin Genet | 2024 Jul | https://www.ncbi.nlm.nih.gov/pubmed/38545656 |
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| Antioxidant Carbon Nanoparticles Inhibit Fibroblast-Like Synoviocyte Invasiveness and Reduce Disease Severity in a Rat Model of Rheumatoid Arthritis. | Tanner MR, Huq R, Sikkema WKA, Nilewski LG, Yosef N, Schmitt C, Flores-Suarez CP, Raugh A, Laragione T, Gulko PS, Tour JM, Beeton C | Antioxidants (Basel, Switzerland) | 33081234 | Antioxidants (Basel) | 2020 Oct 16 | https://www.ncbi.nlm.nih.gov/pubmed/33081234 |
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| WDFY4 is required for cross-presentation in response to viral and tumor antigens. | Theisen DJ, Davidson JT 4th, Briseño CG, Gargaro M, Lauron EJ, Wang Q, Desai P, Durai V, Bagadia P, Brickner JR, Beatty WL, Virgin HW, Gillanders WE, Mosammaparast N, Diamond MS, Sibley LD, Yokoyama W, Schreiber RD, Murphy TL, Murphy KM | Science (New York, N.Y.) | 30409884 | Science | 2018 Nov 9 | https://www.ncbi.nlm.nih.gov/pubmed/30409884 |
| A graph theoretical approach to experimental prioritization in genome-scale investigations. | Grady SK, Peterson KA, Murray SA, Baker EJ, Langston MA, Chesler EJ | Mammalian genome : official journal of the International Mammalian Genome Society | 39191873 | Mamm Genome | 2024 Dec | https://www.ncbi.nlm.nih.gov/pubmed/39191873 |
| Excavating the Genome: Large-Scale Mutagenesis Screening for the Discovery of New Mouse Models. | Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Murray SA, Denegre JM, Schofield PN, King LE Jr, Wiles MV, Pratt CH | The journal of investigative dermatology. Symposium proceedings | 26551941 | J Investig Dermatol Symp Proc | 2015 Nov | https://www.ncbi.nlm.nih.gov/pubmed/26551941 |
| Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes. | Hopkins J, Hwang G, Jacob J, Sapp N, Bedigian R, Oka K, Overbeek P, Murray S, Jordan PW | PLoS genetics | 24992337 | PLoS Genet | 2014 Jul | https://www.ncbi.nlm.nih.gov/pubmed/24992337 |
| The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells. | Taft RA, Low BE, Byers SL, Murray SA, Kutny P, Wiles MV | PloS one | 23844102 | PLoS One | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/23844102 |
| Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice. | Shaheen R, Anazi S, Ben-Omran T, Seidahmed MZ, Caddle LB, Palmer K, Ali R, Alshidi T, Hagos S, Goodwin L, Hashem M, Wakil SM, Abouelhoda M, Colak D, Murray SA, Alkuraya FS | American journal of human genetics | 27018474 | Am J Hum Genet | 2016 Apr 7 | https://www.ncbi.nlm.nih.gov/pubmed/27018474 |
| Safety, efficacy and efficiency of laser-assisted IVF in subfertile mutant mouse strains. | Li MW, Kinchen KL, Vallelunga JM, Young DL, Wright KD, Gorano LN, Wasson K, Lloyd KC | Reproduction (Cambridge, England) | 23315689 | Reproduction | 2013 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/23315689 |
| Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control. | Mianné J, Codner GF, Caulder A, Fell R, Hutchison M, King R, Stewart ME, Wells S, Teboul L | Methods (San Diego, Calif.) | 28363792 | Methods | 2017 May 15 | https://www.ncbi.nlm.nih.gov/pubmed/28363792 |
| Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. | Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV, DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z | Nature neuroscience | 30664766 | Nat Neurosci | 2019 Feb | https://www.ncbi.nlm.nih.gov/pubmed/30664766 |
| Long-read sequencing for fast and robust identification of correct genome-edited alleles: PCR-based and Cas9 capture methods. | McCabe CV, Price PD, Codner GF, Allan AJ, Caulder A, Christou S, Loeffler J, Mackenzie M, Malzer E, Mianné J, Nowicki KJ, O'Neill EJ, Pike FJ, Hutchison M, Petit-Demoulière B, Stewart ME, Gates H, Wells S, Sanderson ND, Teboul L | PLoS genetics | 38457464 | PLoS Genet | 2024 Mar | https://www.ncbi.nlm.nih.gov/pubmed/38457464 |
| Revealing hidden complexities of genomic rearrangements generated with Cas9. | Boroviak K, Fu B, Yang F, Doe B, Bradley A | Scientific reports | 28993641 | Sci Rep | 2017 Oct 9 | https://www.ncbi.nlm.nih.gov/pubmed/28993641 |
| Importing genetically altered animals: ensuring quality. | Birling MC, Fray MD, Kasparek P, Kopkanova J, Massimi M, Matteoni R, Montoliu L, Nutter LMJ, Raspa M, Rozman J, Ryder EJ, Scavizzi F, Voikar V, Wells S, Pavlovic G, Teboul L | Mammalian genome : official journal of the International Mammalian Genome Society | 34536110 | Mamm Genome | 2022 Mar | https://www.ncbi.nlm.nih.gov/pubmed/34536110 |
| Genetically Engineered Mice by Pronuclear DNA microinjection. | Demayo JL, Wang J, Liang D, Zhang R, Demayo FJ | Current protocols in mouse biology | 23024927 | Curr Protoc Mouse Biol | 2012 Sep 1 | https://www.ncbi.nlm.nih.gov/pubmed/23024927 |
| Universal Southern blot protocol with cold or radioactive probes for the validation of alleles obtained by homologous recombination. | Codner GF, Erbs V, Loeffler J, Chessum L, Caulder A, Jullien N, Wells S, Birling MC, Teboul L | Methods (San Diego, Calif.) | 32599056 | Methods | 2021 Jul | https://www.ncbi.nlm.nih.gov/pubmed/32599056 |
| Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis. | Fan Y, Lu H, Liang W, Garcia-Barrio MT, Guo Y, Zhang J, Zhu T, Hao Y, Zhang J, Chen YE | Circulation research | 29467198 | Circ Res | 2018 Mar 30 | https://www.ncbi.nlm.nih.gov/pubmed/29467198 |
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| Screening and validation of genome-edited animals. | Bunton-Stasyshyn RK, Codner GF, Teboul L | Laboratory animals | 34192966 | Lab Anim | 2022 Feb | https://www.ncbi.nlm.nih.gov/pubmed/34192966 |
| High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source. | Cole JM, Symes DR, Lopes NC, Wood JC, Poder K, Alatabi S, Botchway SW, Foster PS, Gratton S, Johnson S, Kamperidis C, Kononenko O, De Lazzari M, Palmer CAJ, Rusby D, Sanderson J, Sandholzer M, Sarri G, Szoke-Kovacs Z, Teboul L, Thompson JM, Warwick JR, Westerberg H, Hill MA, Norris DP, Mangles SPD, Najmudin Z | Proceedings of the National Academy of Sciences of the United States of America | 29871946 | Proc Natl Acad Sci U S A | 2018 Jun 19 | https://www.ncbi.nlm.nih.gov/pubmed/29871946 |
| Anticipating and Identifying Collateral Damage in Genome Editing. | Burgio G, Teboul L | Trends in genetics : TIG | 33039248 | Trends Genet | 2020 Dec | https://www.ncbi.nlm.nih.gov/pubmed/33039248 |
| A gene expression resource generated by genome-wide lacZ profiling in the mouse. | Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA, Souter L, Siragher E, Lillistone C, Green AL, Wardle-Jones H, Carragher DM, Karp NA, Smedley D, Adams NC, Sanger Institute Mouse Genetics Project, Bussell JN, Adams DJ, Ramírez-Solis R, Steel KP, Galli A, White JK | Disease models & mechanisms | 26398943 | Dis Model Mech | 2015 Nov | https://www.ncbi.nlm.nih.gov/pubmed/26398943 |
| Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction. | Codner GF, Lindner L, Caulder A, Wattenhofer-Donzé M, Radage A, Mertz A, Eisenmann B, Mianné J, Evans EP, Beechey CV, Fray MD, Birling MC, Hérault Y, Pavlovic G, Teboul L | BMC cell biology | 27496052 | BMC Cell Biol | 2016 Aug 5 | https://www.ncbi.nlm.nih.gov/pubmed/27496052 |
| Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR. | Haeussler M, Schönig K, Eckert H, Eschstruth A, Mianné J, Renaud JB, Schneider-Maunoury S, Shkumatava A, Teboul L, Kent J, Joly JS, Concordet JP | Genome biology | 27380939 | Genome Biol | 2016 Jul 5 | https://www.ncbi.nlm.nih.gov/pubmed/27380939 |
