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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Authors Journal PubMedID Publication Date
Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Kam, Chen Yuan; Singh, Ishani D; Gonzalez, David G; Matte-Martone, Catherine; Solá, Paloma; Solanas, Guiomar; Bonjoch, Júlia; Marsh, Edward; Hirschi, Karen K; Greco, Valentina Cell 37167971 2023 May 25
Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome. Abutaleb, Nadia O; Atchison, Leigh; Choi, Leandro; Bedapudi, Akhil; Shores, Kevin; Gete, Yantenew; Cao, Kan; Truskey, George A Scientific reports 36977745 2023 Mar 28
Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes. Wang, Alex J; Allen, Allysa; Sofman, Marianna; Sphabmixay, Pierre; Yildiz, Ece; Griffith, Linda G Advanced nanobiomed research 35872804 2022 Jan
Recreating the heart's helical structure-function relationship with focused rotary jet spinning. Chang, Huibin; Liu, Qihan; Zimmerman, John F; Lee, Keel Yong; Jin, Qianru; Peters, Michael M; Rosnach, Michael; Choi, Suji; Kim, Sean L; Ardoña, Herdeline Ann M; MacQueen, Luke A; Chantre, Christophe O; Motta, Sarah E; Cordoves, Elizabeth M; Parker, Kevin Science (New York, N.Y.) 35857545 2022 07 08
A vascularized model of the human liver mimics regenerative responses. Chhabra, Arnav; Song, H-H Greco; Grzelak, Katarzyna A; Polacheck, William J; Fleming, Heather E; Chen, Christopher S; Bhatia, Sangeeta N Proceedings of the National Academy of Sciences of the United States of America 35763565 2022 Jul 12
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models. Singh, Dharaminder; Deosarkar, Sudhir P; Cadogan, Elaine; Flemington, Vikki; Bray, Alysha; Zhang, Jingwen; Reiserer, Ronald S; Schaffer, David K; Gerken, Gregory B; Britt, Clayton M; Werner, Erik M; Gibbons, Francis D; Kostrzewski, Tomasz; Chambers, Chris PLoS biology 35617197 2022 05
Comparison of Bayesian vs Frequentist Adaptive Trial Design in the Stroke Hyperglycemia Insulin Network Effort Trial. Broglio, Kristine; Meurer, William J; Durkalski, Valerie; Pauls, Qi; Connor, Jason; Berry, Donald; Lewis, Roger J; Johnston, Karen C; Barsan, William G JAMA network open 35544137 2022 05 02
Kidney microphysiological models for nephrotoxicity assessment. Mahadeo, Anish; Yeung, Catherine K; Himmelfarb, Jonathan; Kelly, Edward J Current opinion in toxicology 35495549 2022 Jun
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia. Cruz, Nelly M; Reddy, Raghava; McFaline-Figueroa, José L; Tran, Christine; Fu, Hongxia; Freedman, Benjamin S Nature biomedical engineering 35478224 2022 04
Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity. Pamies, David; Wiersma, Daphne; Katt, Moriah E; Zhao, Liang; Burtscher, Johannes; Harris, Georgina; Smirnova, Lena; Searson, Peter C; Hartung, Thomas; Hogberg, Helena T Neurobiology of disease 35398340 2022 07
Endothelial Cell Differentiation and Hemogenic Specification. Aragon, Jordon W; Hirschi, Karen K Cold Spring Harbor perspectives in medicine 35193895 2022 07 29
An autonomously swimming biohybrid fish designed with human cardiac biophysics. Lee, Keel Yong; Park, Sung-Jin; Matthews, David G; Kim, Sean L; Marquez, Carlos Antonio; Zimmerman, John F; Ardoña, Herdeline Ann M; Kleber, Andre G; Lauder, George V; Parker, Kevin Kit Science (New York, N.Y.) 35143298 2022 02 11
Network inference with Granger causality ensembles on single-cell transcriptomics. Deshpande, Atul; Chu, Li-Fang; Stewart, Ron; Gitter, Anthony Cell reports 35139376 2022 02 08
Cyclosporine Induces Fenestra-Associated Injury in Human Renal Microvessels In Vitro. Nagao, Ryan J; Marcu, Raluca; Shin, Yu Jung; Lih, Daniel; Xue, Jun; Arang, Nadia; Wei, Ling; Akilesh, Shreeram; Kaushansky, Alexis; Himmelfarb, Jonathan; Zheng, Ying ACS biomaterials science & engineering 34927415 2022 01 10
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Eicher, Alexandra K; Kechele, Daniel O; Sundaram, Nambirajan; Berns, H Matthew; Poling, Holly M; Haines, Lauren E; Sanchez, J Guillermo; Kishimoto, Keishi; Krishnamurthy, Mansa; Han, Lu; Zorn, Aaron M; Helmrath, Michael A; Wells, James M Cell stem cell 34856121 2022 01 06
Organ-on-a-chip model of vascularized human bone marrow niches. Glaser, Drew E; Curtis, Matthew B; Sariano, Peter A; Rollins, Zachary A; Shergill, Bhupinder S; Anand, Aravind; Deely, Alyssa M; Shirure, Venktesh S; Anderson, Leif; Lowen, Jeremy M; Ng, Natalie R; Weilbaecher, Katherine; Link, Daniel C; George, Steven C Biomaterials 34810038 2022 01
Aquaporin 9 induction in human iPSC-derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency. Laemmle, Alexander; Poms, Martin; Hsu, Bernadette; Borsuk, Mariia; Rüfenacht, Véronique; Robinson, Joshua; Sadowski, Martin C; Nuoffer, Jean-Marc; Häberle, Johannes; Willenbring, Holger Hepatology (Baltimore, Md.) 34786702 2021 Nov 16
milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues. Tamargo, Manuel Alejandro; Nash, Trevor Ray; Fleischer, Sharon; Kim, Youngbin; Vila, Olaia Fernandez; Yeager, Keith; Summers, Max; Zhao, Yimu; Lock, Roberta; Chavez, Miguel; Costa, Troy; Vunjak-Novakovic, Gordana ACS biomaterials science & engineering 34668692 2021 11 08
Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Sakolish, Courtney; Luo, Yu-Syuan; Valdiviezo, Alan; Vernetti, Lawrence A; Rusyn, Ivan; Chiu, Weihsueh A Toxicology 34543702 2021 Nov
A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit. Chiesa, Irene; Di Gesù, Roberto; Overholt, Kalon J; Gottardi, Riccardo Methods in molecular biology (Clifton, N.J.) 34520018 2022
Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. Genet, Nafiisha; Hirschi, Karen K Regenerative medicine 34498495 2021 09
High resolution stereolithography fabrication of perfusable scaffolds to enable long-term meso-scale hepatic culture for disease modeling. Sphabmixay, Pierre; Raredon, Micha Sam Brickman; Wang, Alex J-S; Lee, Howon; Hammond, Paula T; Fang, Nicholas X; Griffith, Linda G Biofabrication 34479229 2021 09 21
The vascular niche in next generation microphysiological systems. Ewald, Makena L; Chen, Yu-Hsi; Lee, Abraham P; Hughes, Christopher C W Lab on a chip 34396383 2021 09 07
Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Blutt, Sarah E; Crawford, Sue E; Bomidi, Carolyn; Zeng, Xi-Lei; Broughman, James R; Robertson, Matthew; Coarfa, Cristian; Tessier, Mary Elizabeth M; Savidge, Tor; Hollinger, F Blaine; Curley, Steven A; Donowitz, Mark; Estes, Mary K American journal of physiology. Gastrointestinal and liver physiology 34288725 2021 09 01
Non-destructive vacuum-assisted measurement of lung elastic modulus. Chen, Jiawen; Mir, Seyed Mohammad; Pinezich, Meghan R; O'Neill, John D; Guenthart, Brandon A; Bacchetta, Matthew; Vunjak-Novakovic, Gordana; Huang, Sarah X L; Kim, Jinho Acta biomaterialia 34192570 2021 Sep 01
The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. Chavkin, Nicholas W; Sano, Soichi; Wang, Ying; Oshima, Kosei; Ogawa, Hayato; Horitani, Keita; Sano, Miho; MacLauchlan, Susan; Nelson, Anders; Setia, Karishma; Vippa, Tanvi; Watanabe, Yosuke; Saucerman, Jeffrey J; Hirschi, Karen K; Gokce, Noyan; Walsh, Kenneth Journal of the American Heart Association 34155901 2021 07 06
Platforms to test the temporospatial capabilities of carrier systems in delivering growth factors to benefit vascular bioengineering. Argueta, Lissenya B; Niles, Jean A; Sakamoto, Jason; Liu, Xuewu; Vega, Stephanie P; Frank, Luba; Paessler, Marco; Cortiella, Joaquin; Nichols, Joan E Nanomedicine : nanotechnology, biology, and medicine 34147665 2021 08
Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus. Rosenthal, Eric S; Elm, Jordan J; Ingles, James; Rogers, Alexander J; Terndrup, Thomas E; Holsti, Maija; Thomas, Danny G; Babcock, Lynn; Okada, Pamela J; Lipsky, Robert H; Miller, Joseph B; Hickey, Robert W; Barra, Megan E; Bleck, Thomas P; Cloyd, James C; Silbergleit, Robert; Lowenstein, Daniel H; Coles, Lisa D; Kapur, Jaideep; Shinnar, Shlomo; Chamberlain, James M; Established Status Epilepticus Treatment Trial Study Group Neurology 34032604 2021 05 11
Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells. Nelson, Elizabeth A; Qiu, Jingyao; Chavkin, Nicholas W; Hirschi, Karen K Journal of visualized experiments : JoVE 33871448 2021 03 31
Vascular endothelial cell specification in health and disease. Marziano, Corina; Genet, Gael; Hirschi, Karen K Angiogenesis 33844116 2021 Apr 12
Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers. Chen, Amanda X; Chhabra, Arnav; Song, H-H Greco; Fleming, Heather E; Chen, Christopher S; Bhatia, Sangeeta N Advanced functional materials 33776613 2020 Nov 25
Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling. Mina, Sara G; Alaybeyoglu, Begum; Murphy, William L; Thomson, James A; Stokes, Cynthia L; Cirit, Murat Frontiers in big data 33693346 2019
Interspecies chimeric conditions affect the developmental rate of human pluripotent stem cells. Brown, Jared; Barry, Christopher; Schmitz, Matthew T; Argus, Cara; Bolin, Jennifer M; Schwartz, Michael P; Van Aartsen, Amy; Steill, John; Swanson, Scott; Stewart, Ron; Thomson, James A; Kendziorski, Christina PLoS computational biology 33647016 2021 03
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Lidberg, Kevin A; Annalora, Andrew J; Jozic, Marija; Elson, Daniel J; Wang, Lu; Bammler, Theo K; Ramm, Susanne; Monteiro, Maria Beatriz; Himmelfarb, Jonathan; Marcus, Craig B; Iversen, Patrick L; Kelly, Edward J Scientific reports 33633318 2021 Feb 25
Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Song, H-H Greco; Lammers, Alex; Sundaram, Subramanian; Rubio, Logan; Chen, Amanda X; Li, Linqing; Eyckmans, Jeroen; Bhatia, Sangeeta N; Chen, Christopher S Advanced functional materials 33613149 2020 Nov 25
An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Hachey, Stephanie J; Movsesyan, Silva; Nguyen, Quy H; Burton-Sojo, Giselle; Tankazyan, Ani; Wu, Jie; Hoang, Tuyen; Zhao, Da; Wang, Shuxiong; Hatch, Michaela M; Celaya, Elizabeth; Gomez, Samantha; Chen, George T; Davis, Ryan T; Nee, Kevin; Pervolarakis, Nicholas; Lawson, Devon A; Kessenbrock, Kai; Lee, Abraham P; Lowengrub, John; Waterman, Marian L; Hughes, Christopher C W Lab on a chip 33605955 2021 04 07
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®. Bircsak, Kristin M; DeBiasio, Richard; Miedel, Mark; Alsebahi, Alaa; Reddinger, Ryan; Saleh, Anthony; Shun, Tongying; Vernetti, Lawrence A; Gough, Albert Toxicology 33359578 2021 Feb 28
Modeling the Complexity of the Metastatic Niche Ex Vivo. Clark, Amanda M Methods in molecular biology (Clifton, N.J.) 33340364 2021
Electroencephalographic Seizures in Emergency Department Patients After Treatment for Convulsive Status Epilepticus. Zehtabchi, Shahriar; Silbergleit, Robert; Chamberlain, James M; Shinnar, Shlomo; Elm, Jordan J; Underwood, Ellen; Rosenthal, Eric S; Bleck, Thomas P; Kapur, Jaideep Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 33337664 2020 Dec 11
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Sakolish, Courtney; Reese, Celeste E; Luo, Yu-Syuan; Valdiviezo, Alan; Schurdak, Mark E; Gough, Albert; Taylor, D Lansing; Chiu, Weihsueh A; Vernetti, Lawrence A; Rusyn, Ivan Toxicology 33307106 2021 01 30
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. Qiu, Jingyao; Nordling, Sofia; Vasavada, Hema H; Butcher, Eugene C; Hirschi, Karen K Cell reports 33264627 2020 Dec 01
Modeling statin myopathy in a human skeletal muscle microphysiological system. Ananthakumar, Anandita; Liu, Yiling; Fernandez, Cristina E; Truskey, George A; Voora, Deepak PloS one 33237943 2020
Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids. Edmonds, Maxwell E; Forshee, Micah D; Woodruff, Teresa K Journal of visualized experiments : JoVE. 33104061 2020 10 07;
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip. Yin, Jianyi; Sunuwar, Laxmi; Kasendra, Magdalena; Yu, Huimin; Tse, Chung-Ming; Talbot Jr, C Conover; Boronina, Tatiana; Cole, Robert; Karalis, Katia; Donowitz, Mark American journal of physiology. Gastrointestinal and liver physiology 33074011 2021 03 01
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip. Yadid, Moran; Lind, Johan U; Ardoña, Herdeline Ann M; Sheehy, Sean P; Dickinson, Lauren E; Eweje, Feyisayo; Bastings, Maartje M C; Pope, Benjamin; O'Connor, Blakely B; Straubhaar, Juerg R; Budnik, Bogdan; Kleber, Andre G; Parker, Kevin Kit Science translational medicine 33055246 2020 10 14
A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. Korentzelos, Dimitrios; Clark, Amanda M; Wells, Alan International journal of molecular sciences. 33022920 2020 Oct 03;
Isolation of Highly Purified and Viable Retinal Endothelial Cells. Chavkin, Nicholas W; Walsh, Kenneth; Hirschi, Karen K Journal of vascular research 33022674 2021
Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs. Liu, Yizhong; Sakolish, Courtney; Chen, Zunwei; Phan, Duc T T; Bender, R Hugh F; Hughes, Christopher C W; Rusyn, Ivan Toxicology. 32980478 2020 Dec 01;
Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety. Chramiec, Alan; Teles, Diogo; Yeager, Keith; Marturano-Kruik, Alessandro; Pak, Joseph; Chen, Timothy; Hao, Luke; Wang, Miranda; Lock, Roberta; Tavakol, Daniel Naveed; Lee, Marcus Busub; Kim, Jinho; Ronaldson-Bouchard, Kacey; Vunjak-Novakovic, Gordana Lab on a chip 32955072 2020 11 24
Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Imaoka, Tomoki; Yang, Jade; Wang, Lu; McDonald, Matthew G; Afsharinejad, Zahra; Bammler, Theo K; Van Ness, Kirk; Yeung, Catherine K; Rettie, Allan E; Himmelfarb, Jonathan; Kelly, Edward J Toxicology 32905824 2020 11
A functional long-term 2D serum-free human hepatic in vitro system for drug evaluation. Oleaga, Carlota; Bridges, L Richard; Persaud, Keisha; McAleer, Christopher W; Long, Christopher J; Hickman, James J Biotechnology progress 32829524 2021 01
Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. Malladi, Shashi; Miranda-Nieves, David; Leng, Lian; Grainger, Stephanie J; Tarabanis, Constantine; Nesmith, Alexander P; Kosaraju, Revanth; Haller, Carolyn A; Parker, Kevin Kit; Chaikof, Elliot L; Günther, Axel ACS biomaterials science & engineering 32685675 2020 07 13
Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. Bhatraju, Pavan K; Cohen, Max; Nagao, Ryan J; Morrell, Eric D; Kosamo, Susanna; Chai, Xin-Ya; Nance, Robin; Dmyterko, Victoria; Delaney, Joseph; Christie, Jason D; Liu, Kathleen D; Mikacenic, Carmen; Gharib, Sina A; Liles, W Conrad; Zheng, Ying; Christiani, David C; Himmelfarb, Jonathan; Wurfel, Mark M BMC nephrology 32680471 2020 07 17
Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase. McKinnon, Kelly E; Getsios, Spiro; Woodruff, Teresa K Biology of reproduction 32614039 2020 08 21
Integrative microphysiological tissue systems of cancer metastasis to the liver. Clark, Amanda M; Allbritton, Nancy L; Wells, Alan Seminars in cancer biology. 32580025 2020 Jun 21;
Testicular organoid formation is a property of immature somatic cells, which self-assemble and exhibit long-term hormone-responsive endocrine function. Edmonds, Maxwell E; Woodruff, Teresa K Biofabrication. 32492667 2020 07 09;
Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection. Foulke-Abel, Jennifer; Yu, Huimin; Sunuwar, Laxmi; Lin, Ruxian; Fleckenstein, James M; Kaper, James B; Donowitz, Mark Gut microbes. 32378997 2020 May 07;
Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. Khodabukus, Alastair; Kaza, Amulya; Wang, Jason; Prabhu, Neel; Goldstein, Richard; Vaidya, Vishal S; Bursac, Nenad Toxicological sciences : an official journal of the Society of Toxicology. 32294208 2020 Jul 01;
Oligoproline-derived nanocarrier for dual stimuli-responsive gene delivery. Gupta, Mukesh K; Lee, Sue Hyun; Crowder, Spencer W; Wang, Xintong; Hofmeister, Lucas H; Nelson, Christopher E; Bellan, Leon M; Duvall, Craig L; Sung, Hak-Joon Journal of materials chemistry. B 32262835 2015 Sep 28
Engineered reproductive tissues. Gargus, Emma S; Rogers, Hunter B; McKinnon, Kelly E; Edmonds, Maxwell E; Woodruff, Teresa K Nature biomedical engineering. 32251392 2020 04;
Applications of the microphysiology systems database for experimental ADME-Tox and disease models. Schurdak, Mark; Vernetti, Lawrence; Bergenthal, Luke; Wolter, Quinn K; Shun, Tong Ying; Karcher, Sandra; Taylor, D Lansing; Gough, Albert Lab on a chip. 32211684 2020 Apr 14;
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. Chamberlain, James M; Kapur, Jaideep; Shinnar, Shlomo; Elm, Jordan; Holsti, Maija; Babcock, Lynn; Rogers, Alex; Barsan, William; Cloyd, James; Lowenstein, Daniel; Bleck, Thomas P; Conwit, Robin; Meinzer, Caitlyn; Cock, Hannah; Fountain, Nathan B; Underwoo Lancet (London, England). 32203691 2020 04 11;
Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle. Kondash, Megan E; Ananthakumar, Anandita; Khodabukus, Alastair; Bursac, Nenad; Truskey, George A Tissue engineering and regenerative medicine. 32200516 2020 Mar 21;
Machine learning to predict developmental neurotoxicity with high-throughput data from 2D bio-engineered tissues. Kuusisto, Finn; Costa, Vitor Santos; Hou, Zhonggang; Thomson, James; Page, David; Stewart, Ron Proceedings of the ... International Conference on Machine Learning and Applications. International Conference on Machine Learning and Applications. 32181450 2019 Dec;
TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes. Jiang, Peng; Chamberlain, Connie S; Vanderby, Ray; Thomson, James A; Stewart, Ron Nucleic acids research. 32123905 2020 05 21;
Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity. Wang, Chenyan; Koo, Sangmo; Park, Minok; Vangelatos, Zacharias; Hoang, Plansky; Conklin, Bruce R; Grigoropoulos, Costas P; Healy, Kevin E; Ma, Zhen Advanced healthcare materials. 32090507 2020 Apr;
Perspectives on In Vitro to In Vivo Extrapolations. Hartung, Thomas Applied in vitro toxicology. 31890748 2018 Dec 01;
Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Sakolish, Courtney; Chen, Zunwei; Dalaijamts, Chimeddulam; Mitra, Kusumica; Liu, Yina; Fulton, Tracy; Wade, Terry L; Kelly, Edward J; Rusyn, Ivan; Chiu, Weihsueh A Toxicology in vitro : an international journal published in association with BIBRA. 31857146 2020 Mar;
Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. Ma, Bo; Khazali, Ahmad; Shao, Hanshuang; Jiang, Yuhan; Wells, Alan Cell communication and signaling : CCS. 31831069 2019 Dec 12;
Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics. Barry, Christopher; Schmitz, Matthew T; Argus, Cara; Bolin, Jennifer M; Probasco, Mitchell D; Leng, Ning; Duffin, Bret M; Steill, John; Swanson, Scott; McIntosh, Brian E; Stewart, Ron; Kendziorski, Christina; Thomson, James A; Bacher, Rhonda PLoS computational biology. 31815944 2019 12;
Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity. Weng, Kuo-Chan; Kurokawa, Yosuke K; Hajek, Brianna S; Paladin, Jack A; Shirure, Venktesh S; George, Steven C Tissue engineering. Part C, Methods. 31797733 2020 Jan;
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. Kapur, Jaideep; Elm, Jordan; Chamberlain, James M; Barsan, William; Cloyd, James; Lowenstein, Daniel; Shinnar, Shlomo; Conwit, Robin; Meinzer, Caitlyn; Cock, Hannah; Fountain, Nathan; Connor, Jason T; Silbergleit, Robert; NETT and PECARN Investigators The New England journal of medicine. 31774955 2019 11 28;
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. Garbern, Jessica C; Helman, Aharon; Sereda, Rebecca; Sarikhani, Mohsen; Ahmed, Aishah; Escalante, Gabriela O; Ogurlu, Roza; Kim, Sean L; Zimmerman, John F; Cho, Alexander; MacQueen, Luke; Bezzerides, Vassilios J; Parker, Kevin Kit; Melton, Douglas A; Lee, Circulation. 31707831 2020 01 28;
Lessons from the Established Status Epilepticus Treatment Trial. Cock, Hannah R; Coles, Lisa D; Elm, Jordan; Silbergleit, Robert; Chamberlain, James M; Cloyd, James C; Fountain, Nathan; Shinnar, Shlomo; Lowenstein, Dan; Conwit, Robin; Bleck, Thomas P; Kapur, Jaideep Epilepsy & behavior : E&B. 31653603 2019 Dec;
Endothelial Cell Development and Its Application to Regenerative Medicine. Qiu, Jingyao; Hirschi, Karen K Circulation research 31518171 2019 08 02
Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype. Ronaldson-Bouchard, Kacey; Yeager, Keith; Teles, Diogo; Chen, Timothy; Ma, Stephen; Song, LouJin; Morikawa, Kumi; Wobma, Holly M; Vasciaveo, Alessandro; Ruiz, Edward C; Yazawa, Masayuki; Vunjak-Novakovic, Gordana Nature protocols. 31492957 2019 10;
A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Nguyen, Duc-Huy T; Lee, Esak; Alimperti, Styliani; Norgard, Robert J; Wong, Alec; Lee, Jake June-Koo; Eyckmans, Jeroen; Stanger, Ben Z; Chen, Christopher S Science advances. 31489365 2019 Aug;
An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells. Chu, Li-Fang; Mamott, Daniel; Ni, Zijian; Bacher, Rhonda; Liu, Cathy; Swanson, Scott; Kendziorski, Christina; Stewart, Ron; Thomson, James A Cell reports. 31461642 2019 Aug 27;
Engineered skeletal muscles for disease modeling and drug discovery. Wang, Jason; Khodabukus, Alastair; Rao, Lingjun; Vandusen, Keith; Abutaleb, Nadia; Bursac, Nenad Biomaterials. 31419653 2019 Nov;
The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. Ma, Bo; Wells, Alan; Clark, Amanda M Seminars in cancer biology. 31376430 2019 Jul 31;
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Argemi, Josepmaria; Latasa, Maria U; Atkinson, Stephen R; Blokhin, Ilya O; Massey, Veronica; Gue, Joel P; Cabezas, Joaquin; Lozano, Juan J; Van Booven, Derek; Bell, Aaron; Cao, Sheng; Vernetti, Lawrence A; Arab, Juan P; Ventura-Cots, Meritxell; Edmunds, Lia R; Fondevilla, Constantino; Stärkel, Peter; Dubuquoy, Laurent; Louvet, Alexandre; Odena, Gemma; Gomez, Juan L; Aragon, Tomas; Altamirano, Jose; Caballeria, Juan; Jurczak, Michael J; Taylor, D Lansing; Berasain, Carmen; Wahlestedt, Claes; Monga, Satdarshan P; Morgan, Marsha Y; Sancho-Bru, Pau; Mathurin, Philippe; Furuya, Shinji; Lackner, Carolin; Rusyn, Ivan; Shah, Vijay H; Thursz, Mark R; Mann, Jelena; Avila, Matias A; Bataller, Ramon Nature communications. 31311938 2019 Jul 16;
Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Park, Sung-Jin; Zhang, Donghui; Qi, Yan; Li, Yifei; Lee, Keel Yong; Bezzerides, Vassilios J; Yang, Pengcheng; Xia, Shutao; Kim, Sean L; Liu, Xujie; Lu, Fujian; Pasqualini, Francesco S; Campbell, Patrick H; Geva, Judith; Roberts, Amy E; Kleber, Andre G; Abrams, Dominic J; Pu, William T; Parker, Kevin Kit Circulation. 31311300 2019 Jul 30;
Oxygen consumption in human, tissue-engineered myobundles during basal and electrical stimulation conditions. Davis, Brittany N; Yen, Ringo; Prasad, Varun; Truskey, George A APL bioengineering. 31149650 2019 Jun;
Adult Stem Cell Functioning in the Tumor Micro-Environment. Jiang, Yuhan; Wells, Alan; Sylakowski, Kyle; Clark, Amanda M; Ma, Bo International journal of molecular sciences 31130595 2019 May 25
A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia. Zhang, Jue; McIntosh, Brian E; Wang, Bowen; Brown, Matthew E; Probasco, Mitchell D; Webster, Sarah; Duffin, Bret; Zhou, Ying; Guo, Lian-Wang; Burlingham, William J; Kent, Craig; Ferris, Michael; Thomson, James A Stem cell reports. 31080110 2019 Jun 11;
Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. Ma, Zhen; Huebsch, Nathaniel; Koo, Sangmo; Mandegar, Mohammad A; Siemons, Brian; Boggess, Steven; Conklin, Bruce R; Grigoropoulos, Costas P; Healy, Kevin E Nature biomedical engineering. 31015724 2018 12;
A tissue-engineered scale model of the heart ventricle. MacQueen, Luke A; Sheehy, Sean P; Chantre, Christophe O; Zimmerman, John F; Pasqualini, Francesco S; Liu, Xujie; Goss, Josue A; Campbell, Patrick H; Gonzalez, Grant M; Park, Sung-Jin; Capulli, Andrew K; Ferrier, John P; Kosar, T Fettah; Mahadevan, L; Pu, William T; Parker, Kevin Kit Nature biomedical engineering. 31015723 2018 12;
Modeling the Effect of TNF-? upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles. Davis, Brittany N J; Santoso, Jeffrey W; Walker, Michaela J; Oliver, Catherine E; Cunningham, Michael M; Boehm, Christian A; Dawes, Danielle; Lasater, Samantha L; Huffman, Kim; Kraus, William E; Truskey, George A Annals of biomedical engineering. 30963383 2019 Jul;
Microfabricated blood vessels for modeling the vascular transport barrier. Polacheck, William J; Kutys, Matthew L; Tefft, Juliann B; Chen, Christopher S Nature protocols. 30953042 2019 05;
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Tissue engineering of human hair follicles using a biomimetic developmental approach. Abaci, Hasan Erbil; Coffman, Abigail; Doucet, Yanne; Chen, James; Jacków, Joanna; Wang, Etienne; Guo, Zongyou; Shin, Jung U; Jahoda, Colin A; Christiano, Angela M Nature communications. 30546011 2018 12 13;
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Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Liu, Bohao; Lee, Benjamin W; Nakanishi, Koki; Villasante, Aranzazu; Williamson, Rebecca; Metz, Jordan; Kim, Jinho; Kanai, Mariko; Bi, Lynn; Brown, Kristy; Di Paolo, Gilbert; Homma, Shunichi; Sims, Peter A; Topkara, Veli K; Vunjak-Novakovic, Gordana Nature biomedical engineering. 30271672 2018 May;
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Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. Oleaga, Carlota; Riu, Anne; Rothemund, Sandra; Lavado, Andrea; McAleer, Christopher W; Long, Christopher J; Persaud, Keisha; Narasimhan, Narasimhan Sriram; Tran, My; Roles, Jeffry; Carmona-Moran, Carlos A; Sasserath, Trevor; Elbrecht, Daniel H; Kumanchik, Lee; Bridges, L Richard; Martin, Candace; Schnepper, Mark T; Ekman, Gail; Jackson, Max; Wang, Ying I; Note, Reine; Langer, Jessica; Teissier, Silvia; Hickman, James J Biomaterials. 30130706 2018 11;
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Production and transplantation of bioengineered lung into a large-animal model. Nichols, Joan E; La Francesca, Saverio; Niles, Jean A; Vega, Stephanie P; Argueta, Lissenya B; Frank, Luba; Christiani, David C; Pyles, Richard B; Himes, Blanca E; Zhang, Ruyang; Li, Su; Sakamoto, Jason; Rhudy, Jessica; Hendricks, Greg; Begarani, Filippo; Liu, Xuewu; Patrikeev, Igor; Pal, Rahul; Usheva, Emiliya; Vargas, Grace; Miller, Aaron; Woodson, Lee; Wacher, Adam; Grimaldo, Maria; Weaver, Daniil; Mlcak, Ron; Cortiella, Joaquin Science translational medicine. 30068570 2018 08 01;
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Li, Xiang; George, Subin M; Vernetti, Lawrence; Gough, Albert H; Taylor, D Lansing Lab on a chip. 30063238 2018 08 21;
Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Ishikawa, Takuro; Hosaka, Yoshinao Z; Beckwitt, Colin; Wells, Alan; Oltvai, Zoltán N; Warita, Katsuhiko Oncotarget. 30034619 2018 Jun 29;
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Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease. Popik, Waldemar; Correa, Hernan; Khatua, Atanu; Aronoff, David M; Alcendor, Donald J Journal of translational science. 29977613 2019 Feb;
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Yin, Jianyi; Tse, Chung-Ming; Avula, Leela Rani; Singh, Varsha; Foulke-Abel, Jennifer; de Jonge, Hugo R; Donowitz, Mark Cellular and molecular gastroenterology and hepatology. 29930980 2018;
Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. Chen, Z; Tang, M; Huang, D; Jiang, W; Li, M; Ji, H; Park, J; Xu, B; Atchison, L J; Truskey, G A; Leong, K W Lab on a chip. 29927449 2018 07 10;
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A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Chen, Huanhuan Joyce; Miller, Paula; Shuler, Michael L Lab on a chip. 29881844 2018 07 10;
Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies. Maass, Christian; Dallas, Matthew; LaBarge, Matthew E; Shockley, Michael; Valdez, Jorge; Geishecker, Emily; Stokes, Cynthia L; Griffith, Linda G; Cirit, Murat Scientific reports. 29789564 2018 May 22;
High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Czerniecki, Stefan M; Cruz, Nelly M; Harder, Jennifer L; Menon, Rajasree; Annis, James; Otto, Edgar A; Gulieva, Ramila E; Islas, Laura V; Kim, Yong Kyun; Tran, Linh M; Martins, Timothy J; Pippin, Jeffrey W; Fu, Hongxia; Kretzler, Matthias; Shankland, Stuart J; Himmelfarb, Jonathan; Moon, Randall T; Paragas, Neal; Freedman, Benjamin S Cell stem cell. 29779890 2018 Jun 01;
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RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. Thakore, Pratiksha I; Kwon, Jennifer B; Nelson, Christopher E; Rouse, Douglas C; Gemberling, Matthew P; Oliver, Matthew L; Gersbach, Charles A Nature communications. 29700298 2018 Apr 26;
In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Khodabukus, Alastair; Prabhu, Neel; Wang, Jason; Bursac, Nenad Advanced healthcare materials. 29696831 2018 08;
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide. Wang, Hong-Xia; Song, Ziyuan; Lao, Yeh-Hsing; Xu, Xin; Gong, Jing; Cheng, Du; Chakraborty, Syandan; Park, Ji Sun; Li, Mingqiang; Huang, Dantong; Yin, Lichen; Cheng, Jianjun; Leong, Kam W Proceedings of the National Academy of Sciences of the United States of America. 29686087 2018 May 08;
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Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes. Hoang, Plansky; Huebsch, Nathaniel; Bang, Shin Hyuk; Siemons, Brian A; Conklin, Bruce R; Healy, Kevin E; Ma, Zhen; Jacquir, Sabir Biotechnology and bioengineering. 29663322 2018 08;
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Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Ronaldson-Bouchard, Kacey; Ma, Stephen P; Yeager, Keith; Chen, Timothy; Song, LouJin; Sirabella, Dario; Morikawa, Kumi; Teles, Diogo; Yazawa, Masayuki; Vunjak-Novakovic, Gordana Nature. 29618819 2018 Apr;
Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. Kotha, Surya; Sun, Sijie; Adams, Amie; Hayes, Brian; Phong, Kiet T; Nagao, Ryan; Reems, Jo-Anna; Gao, Dayong; Torok-Storb, Beverly; López, José A; Zheng, Ying PloS one. 29617409 2018;
Multifaceted Roles of Connexin 43 in Stem Cell Niches. Genet, Nafiisha; Bhatt, Neha; Bourdieu, Antonin; Hirschi, Karen K Current stem cell reports. 29600160 2018;
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Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. Ronaldson-Bouchard, Kacey; Vunjak-Novakovic, Gordana Cell stem cell. 29499151 2018 03 01;
Multidrug Resistance Protein 1 Deficiency Promotes Doxorubicin-Induced Ovarian Toxicity in Female Mice. Wang, Yingzheng; Liu, Mingjun; Zhang, Jiyang; Liu, Yuwen; Kopp, Megan; Zheng, Weiwei; Xiao, Shuo Toxicological sciences : an official journal of the Society of Toxicology. 29462422 2018 May 01;
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The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms. Kang, Inhae; Chu, Charleen T; Kaufman, Brett A FEBS letters. 29364506 2018 Mar;
Human bone perivascular niche-on-a-chip for studying metastatic colonization. Marturano-Kruik, Alessandro; Nava, Michele Maria; Yeager, Keith; Chramiec, Alan; Hao, Luke; Robinson, Samuel; Guo, Edward; Raimondi, Manuela Teresa; Vunjak-Novakovic, Gordana Proceedings of the National Academy of Sciences of the United States of America. 29363599 2018 Feb 06;
A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. Clark, Amanda M; Kumar, Manu P; Wheeler, Sarah E; Young, Carissa L; Venkataramanan, Raman; Stolz, Donna B; Griffith, Linda G; Lauffenburger, Douglas A; Wells, Alan Molecular & cellular proteomics : MCP. 29353230 2018 Apr;
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications. Nawroth, Janna C; Scudder, Lisa L; Halvorson, Ryan T; Tresback, Jason; Ferrier, John P; Sheehy, Sean P; Cho, Alex; Kannan, Suraj; Sunyovszki, Ilona; Goss, Josue A; Campbell, Patrick H; Parker, Kevin Kit Biofabrication. 29337695 2018 Jan 16;
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Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. Chang, Shih-Yu; Weber, Elijah J; Sidorenko, Viktoriya S; Chapron, Alenka; Yeung, Catherine K; Gao, Chunying; Mao, Qingcheng; Shen, Danny; Wang, Joanne; Rosenquist, Thomas A; Dickman, Kathleen G; Neumann, Thomas; Grollman, Arthur P; Kelly, Edward J; Himmel JCI insight. 29202460 2017 Nov 16;
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Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma. Villasante, A; Sakaguchi, K; Kim, J; Cheung, N K; Nakayama, M; Parsa, H; Okano, T; Shimizu, T; Vunjak-Novakovic, G Theranostics. 29158813 2017;
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Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Dioufa, Nikolina; Clark, Amanda M; Ma, Bo; Beckwitt, Colin H; Wells, Alan Molecular cancer. 29137633 2017 Nov 14;
Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nguyen, Eric H; Daly, William T; Le, Ngoc Nhi T; Farnoodian, Mitra; Belair, David G; Schwartz, Michael P; Lebakken, Connie S; Ananiev, Gene E; Saghiri, Mohammad Ali; Knudsen, Thomas B; Sheibani, Nader; Murphy, William L Nature biomedical engineering. 29104816 2017;
The life cycles of six multi-center adaptive clinical trials focused on neurological emergencies developed for the Advancing Regulatory Science initiative of the National Institutes of Health and US Food and Drug Administration: Case studies from the Adap Guetterman, Timothy C; Fetters, Michael D; Mawocha, Samkeliso; Legocki, Laurie J; Barsan, William G; Lewis, Roger J; Berry, Donald A; Meurer, William J SAGE open medicine. 29085638 2017;
Application of induced pluripotent stem cells to model smooth muscle cell function in vascular diseases. Ji, HaYeun; Kim, Hye Sung; Kim, Hae-Won; Leong, Kam W Current opinion in biomedical engineering. 29082353 2017 Mar;
Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Watson, David E; Hunziker, Rosemarie; Wikswo, John P Experimental biology and medicine (Maywood, N.J.). 29065799 2017 Oct;
Microphysiologic systems in female reproductive biology. Young, Alexandria N; Moyle-Heyrman, Georgette; Kim, J Julie; Burdette, Joanna E Experimental biology and medicine (Maywood, N.J.). 29065798 2017 11;
Self-contained, low-cost Body-on-a-Chip systems for drug development. Wang, Ying I; Oleaga, Carlota; Long, Christopher J; Esch, Mandy B; McAleer, Christopher W; Miller, Paula G; Hickman, James J; Shuler, Michael L Experimental biology and medicine (Maywood, N.J.). 29065797 2017 11;
Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component? Cyr, Kevin J; Avaldi, Omero M; Wikswo, John P Experimental biology and medicine (Maywood, N.J.). 29065796 2017 Nov;
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MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. Kader, Muhamuda; Alaoui-El-Azher, Mounia; Vorhauer, Jennie; Kode, Bhushan B; Wells, Jakob Z; Stolz, Donna; Michalopoulos, George; Wells, Alan; Scott, Melanie; Ismail, Nahed PLoS pathogens. 29049365 2017 Oct;
Biomechanical regulation of drug sensitivity in an engineered model of human tumor. Marturano-Kruik, A; Villasante, A; Yaeger, K; Ambati, S R; Chramiec, A; Raimondi, M T; Vunjak-Novakovic, G Biomaterials. 29040875 2018 Jan;
Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells. Lee, Jung Bok; Balikov, Daniel A; Yang, Jae Won; Kim, Ki Seok; Park, Hun Kuk; Kim, Jeong Koo; Kwon, Il Keun; Bellan, Leon M; Sung, Hak-Joon Polymers. 29034114 2016 Jan;
Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening. Lind, Johan U; Yadid, Moran; Perkins, Ian; O'Connor, Blakely B; Eweje, Feyisayo; Chantre, Christophe O; Hemphill, Matthew A; Yuan, Hongyan; Campbell, Patrick H; Vlassak, Joost J; Parker, Kevin K Lab on a chip. 28976521 2017 Oct 25;
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Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease. Cruz, Nelly M; Song, Xuewen; Czerniecki, Stefan M; Gulieva, Ramila E; Churchill, Angela J; Kim, Yong Kyun; Winston, Kosuke; Tran, Linh M; Diaz, Marco A; Fu, Hongxia; Finn, Laura S; Pei, York; Himmelfarb, Jonathan; Freedman, Benjamin S Nature materials. 28967916 2017 Nov;
In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4(+) T Lymphocytes. Matta, Poojitha; Sherrod, Stacy D; Marasco, Christina C; Moore, Daniel J; McLean, John A; Weitkamp, Joern-Hendrik Journal of immunology (Baltimore, Md. : 1950). 28947540 2017 Nov 01;
RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. Jiang, Peng; Hou, Zhonggang; Bolin, Jennifer M; Thomson, James A; Stewart, Ron Toxicological sciences : an official journal of the Society of Toxicology. 28903495 2017 Sep 01;
Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Sivarapatna, Amogh; Ghaedi, Mahboobe; Xiao, Yang; Han, Edward; Aryal, Binod; Zhou, Jing; Fernandez-Hernando, Carlos; Qyang, Yibing; Hirschi, Karen K; Niklason, Laura E Cell transplantation. 28901188 2017 08;
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Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model. Villasante, Aranzazu; Marturano-Kruik, Alessandro; Ambati, Srikanth R; Liu, Zen; Godier-Furnemont, Amandine; Parsa, Hesam; Lee, Benjamin W; Moore, Malcolm A S; Vunjak-Novakovic, Gordana Theranostics. 27279906 2016;
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Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Jiang, Yangzi; Cai, Youzhi; Zhang, Wei; Yin, Zi; Hu, Changchang; Tong, Tong; Lu, Ping; Zhang, Shufang; Neculai, Dante; Tuan, Rocky S; Ouyang, Hong Wei Stem cells translational medicine. 27130221 2016 Jun;
Bioengineered Models of Solid Human Tumors for Cancer Research. Marturano-Kruik, Alessandro; Villasante, Aranzazu; Vunjak-Novakovic, Gordana Methods in molecular biology (Clifton, N.J.). 27115504 2016 Apr 27;
Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Huebsch, Nathaniel; Loskill, Peter; Deveshwar, Nikhil; Spencer, C Ian; Judge, Luke M; Mandegar, Mohammad A; Fox, Cade B; Mohamed, Tamer M A; Ma, Zhen; Mathur, Anurag; Sheehan, Alice M; Truong, Annie; Saxton, Mike; Yoo, Jennie; Srivastava, Deepak; Desai, Tejal A; So, Po-Lin; Healy, Kevin E; Conklin, Bruce R Scientific reports. 27095412 2016;
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Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Zanotelli, Matthew R; Ardalani, Hamisha; Zhang, Jue; Hou, Zhonggang; Nguyen, Eric H; Swanson, Scott; Nguyen, Bao Kim; Bolin, Jennifer; Elwell, Angela; Bischel, Lauren L; Xie, Angela W; Stewart, Ron; Beebe, David J; Thomson, James A; Schwartz, Michael P; Murphy, William L Acta biomaterialia. 26945632 2016 Apr 15;
A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity. Bale, Shyam Sundhar; Sridharan, Gautham Vivek; Golberg, Inna; Prodanov, Ljupcho; McCarty, William J; Usta, Osman Berk; Jindal, Rohit; Yarmush, Martin L Technology. 26925437 2015 Dec;
Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. Cheng, Cindy S; Ran, Lydia; Bursac, Nenad; Kraus, William E; Truskey, George A Tissue engineering. Part A. 26891613 2016 Apr;
SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. Tobita, Takamasa; Guzman-Lepe, Jorge; Takeishi, Kazuki; Nakao, Toshimasa; Wang, Yang; Meng, Fanying; Deng, Chu-Xia; Collin de l'Hortet, Alexandra; Soto-Gutierrez, Alejandro PloS one. 26890260 2016;
Human Vascular Microphysiological System for in vitro Drug Screening. Fernandez, C E; Yen, R W; Perez, S M; Bedell, H W; Povsic, T J; Reichert, W M; Truskey, G A Scientific reports. 26888719 2016;
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators. Moyle-Heyrman, Georgette; Schipma, Matthew J; Dean, Matthew; Davis, David A; Burdette, Joanna E Journal of ovarian research. 26879975 2016 Feb 15;
Transdifferentiation of human endothelial progenitors into smooth muscle cells. Ji, HaYeun; Atchison, Leigh; Chen, Zaozao; Chakraborty, Syandan; Jung, Youngmee; Truskey, George A; Christoforou, Nicolas; Leong, Kam W Biomaterials. 26874281 2016 Apr;
Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue. Lee, Benjamin W; Liu, Bohao; Pluchinsky, Adam; Kim, Nathan; Eng, George; Vunjak-Novakovic, Gordana Advanced healthcare materials. 26865105 2016 Apr;
Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. Aratyn-Schaus, Yvonne; Pasqualini, Francesco S; Yuan, Hongyan; McCain, Megan L; Ye, George J C; Sheehy, Sean P; Campbell, Patrick H; Parker, Kevin Kit The Journal of cell biology. 26858266 2016 Feb 15;
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. In, Julie; Foulke-Abel, Jennifer; Zachos, Nicholas C; Hansen, Anne-Marie; Kaper, James B; Bernstein, Harris D; Halushka, Marc; Blutt, Sarah; Estes, Mary K; Donowitz, Mark; Kovbasnjuk, Olga Cellular and molecular gastroenterology and hepatology. 26855967 2016 Jan 1;
Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs. Oleaga, Carlota; Bernabini, Catia; Smith, Alec S T; Srinivasan, Balaji; Jackson, Max; McLamb, William; Platt, Vivien; Bridges, Richard; Cai, Yunqing; Santhanam, Navaneetha; Berry, Bonnie; Najjar, Sarah; Akanda, Nesar; Guo, Xiufang; Martin, Candace; Ekman, Scientific reports. 26837601 2016;
Angiotensin II Induced Cardiac Dysfunction on a Chip. Horton, Renita E; Yadid, Moran; McCain, Megan L; Sheehy, Sean P; Pasqualini, Francesco S; Park, Sung-Jin; Cho, Alexander; Campbell, Patrick; Parker, Kevin Kit PloS one. 26808388 2016;
High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. McGarrah, Robert W; Craig, Damian M; Haynes, Carol; Dowdy, Z Elaine; Shah, Svati H; Kraus, William E Atherosclerosis. 26803432 2016 Mar;
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. Eng, George; Lee, Benjamin W; Protas, Lev; Gagliardi, Mark; Brown, Kristy; Kass, Robert S; Keller, Gordon; Robinson, Richard B; Vunjak-Novakovic, Gordana Nature communications. 26785135 2016;
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Tissue-Engineering for the Study of Cardiac Biomechanics. Ma, Stephen P; Vunjak-Novakovic, Gordana Journal of biomechanical engineering. 26720588 2016 Feb;
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Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism. Yamaura, Yoshiyuki; Chapron, Brian D; Wang, Zhican; Himmelfarb, Jonathan; Thummel, Kenneth E Drug metabolism and disposition: the biological fate of chemicals. 26700954 2016 Mar;
Liver-Regenerative Transplantation: Regrow and Reset. Collin de l'Hortet, A; Takeishi, K; Guzman-Lepe, J; Handa, K; Matsubara, K; Fukumitsu, K; Dorko, K; Presnell, S C; Yagi, H; Soto-Gutierrez, A American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 26699680 2016 Jun;
Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Heylman, Christopher; Datta, Rupsa; Sobrino, Agua; George, Steven; Gratton, Enrico PloS one. 26695765 2015;
Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification. Logan, David J; Shan, Jing; Bhatia, Sangeeta N; Carpenter, Anne E Methods (San Diego, Calif.). 26687239 2016 Mar 1;
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Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. Zachos, Nicholas C; Kovbasnjuk, Olga; Foulke-Abel, Jennifer; In, Julie; Blutt, Sarah E; de Jonge, Hugo R; Estes, Mary K; Donowitz, Mark The Journal of biological chemistry. 26677228 2016 Feb 19;
A Novel Three-Dimensional Human Peritubular Microvascular System. Ligresti, Giovanni; Nagao, Ryan J; Xue, Jun; Choi, Yoon Jung; Xu, Jin; Ren, Shuyu; Aburatani, Takahide; Anderson, Susan K; MacDonald, James W; Bammler, Theo K; Schwartz, Stephen M; Muczynski, Kimberly A; Duffield, Jeremy S; Himmelfarb, Jonathan; Zheng, Yi Journal of the American Society of Nephrology : JASN. 26657868 2016 Aug;
Fibrous scaffolds for building hearts and heart parts. Capulli, A K; MacQueen, L A; Sheehy, Sean P; Parker, K K Advanced drug delivery reviews. 26656602 2016 Jan 15;
A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis. Smirnova, L; Harris, G; Delp, J; Valadares, M; Pamies, D; Hogberg, H T; Waldmann, T; Leist, M; Hartung, T Archives of toxicology. 26647301 2016 Nov;
Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. Bursac, Nenad; Juhas, Mark; Rando, Thomas A Annual review of biomedical engineering. 26643021 2015;
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Novel behavior of the chromatographic separation of linear and cyclic polymers. Montenegro-Burke, J Rafael; Bennett, Jackson M; McLean, John A; Hercules, David M Analytical and bioanalytical chemistry. 26637218 2016 Jan;
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Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model. Rivera-Burgos, Dinelia; Sarkar, Ujjal; Lever, Amanda R; Avram, Michael J; Coppeta, Jonathan R; Wishnok, John S; Borenstein, Jeffrey T; Tannenbaum, Steven R Drug metabolism and disposition: the biological fate of chemicals. 26586376 2016 Feb;
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Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Brown, Jacquelyn A; Pensabene, Virginia; Markov, Dmitry A; Allwardt, Vanessa; Neely, M Diana; Shi, Mingjian; Britt, Clayton M; Hoilett, Orlando S; Yang, Qing; Brewer, Bryson M; Samson, Philip C; McCawley, Lisa J; May, James M; Webb, Donna J; Li, Deyu; Bow Biomicrofluidics. 26576206 2015 Sep;
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Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. Yu, J; Cilfone, N A; Large, E M; Sarkar, U; Wishnok, J S; Tannenbaum, S R; Hughes, D J; Lauffenburger, D A; Griffith, L G; Stokes, C L; Cirit, M CPT: pharmacometrics & systems pharmacology. 26535159 2015 Oct;
Physiome-on-a-Chip: The Challenge of ''Scaling'' in Design, Operation, and Translation of Microphysiological Systems. Stokes, C L; Cirit, M; Lauffenburger, D A CPT: pharmacometrics & systems pharmacology. 26535154 2015 Oct;
Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization. McCarty, William J; Prodanov, Ljupcho; Bale, Shyam Sundhar; Bhushan, Abhinav; Jindal, Rohit; Yarmush, Martin L; Usta, O Berk Journal of visualized experiments : JoVE. 26485274 2015;
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Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. Jung, Youngmee; Ji, HaYeun; Chen, Zaozao; Fai Chan, Hon; Atchison, Leigh; Klitzman, Bruce; Truskey, George; Leong, Kam W Scientific reports. 26456074 2015;
Systems-Wide High-Dimensional Data Acquisition and Informatics Using Structural Mass Spectrometry Strategies. Sherrod, Stacy D; McLean, John A Clinical chemistry. 26453699 2016 Jan;
RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis. Craciun, Florin L; Bijol, Vanesa; Ajay, Amrendra K; Rao, Poornima; Kumar, Ramya K; Hutchinson, John; Hofmann, Oliver; Joshi, Nikita; Luyendyk, James P; Kusebauch, Ulrike; Moss, Christopher L; Srivastava, Anand; Himmelfarb, Jonathan; Waikar, Sushrut S; Moritz, Robert L; Vaidya, Vishal S Journal of the American Society of Nephrology : JASN. 26449608 2016 Jun;
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. Saxena, Kapil; Blutt, Sarah E; Ettayebi, Khalil; Zeng, Xi-Lei; Broughman, James R; Crawford, Sue E; Karandikar, Umesh C; Sastri, Narayan P; Conner, Margaret E; Opekun, Antone R; Graham, David Y; Qureshi, Waqar; Sherman, Vadim; Foulke-Abel, Jennifer; In, J Journal of virology. 26446608 2015 Oct 07;
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Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin. Pellett, Sabine; Schwartz, Michael P; Tepp, William H; Josephson, Richard; Scherf, Jacob M; Pier, Christina L; Thomson, James A; Murphy, William L; Johnson, Eric A Scientific reports. 26411797 2015;
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. Schwartz, Michael P; Hou, Zhonggang; Propson, Nicholas E; Zhang, Jue; Engstrom, Collin J; Santos Costa, Vitor; Jiang, Peng; Nguyen, Bao Kim; Bolin, Jennifer M; Daly, William; Wang, Yu; Stewart, Ron; Page, C David; Murphy, William L; Thomson, James A Proceedings of the National Academy of Sciences of the United States of America. 26392547 2015 Oct 6;
Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. Le, Ngoc Nhi T; Zorn, Stefan; Schmitt, Samantha K; Gopalan, Padma; Murphy, William L Acta biomaterialia. 26386315 2016 Apr 1;
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Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering. Sun, Aaron X; Lin, Hang; Beck, Angela M; Kilroy, Evan J; Tuan, Rocky S Frontiers in bioengineering and biotechnology. 26347860 2015;
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Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems. Berry, Bonnie J; Akanda, Nesar; Smith, Alec S T; Long, Christopher J; Schnepper, Mark T; Guo, Xiufang; Hickman, James J Biotechnology progress. 26317319 2015 Nov-Dec;
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Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Shlomai, Amir; Schwartz, Robert E; Ramanan, Vyas; Bhatta, Ankit; de Jong, Ype P; Bhatia, Sangeeta N; Rice, Charles M Proceedings of the National Academy of Sciences of the United States of America. 25092305 2014 Aug 19;
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Developing microphysiological systems for use as regulatory tools--challenges and opportunities. Andersen, Melvin E; Betts, Kellyn; Dragan, Yvonne; Fitzpatrick, Suzanne; Goodman, Jesse L; Hartung, Thomas; Himmelfarb, Jonathan; Ingber, Donald E; Jacobs, Abigail; Kavlock, Robert; Kolaja, Kyle; Stevens, James L; Tagle, Dan; Lansing Taylor, D; Throckmort ALTEX. 25061900 2014;
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Cell and tissue engineering for liver disease. Bhatia, Sangeeta N; Underhill, Gregory H; Zaret, Kenneth S; Fox, Ira J Science translational medicine 25031271 2014 Jul 16
Tissue-engineered microenvironment systems for modeling human vasculature. Tourovskaia, Anna; Fauver, Mark; Kramer, Gregory; Simonson, Sara; Neumann, Thomas Experimental biology and medicine (Maywood, N.J.). 25030480 2014 Sep;
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. Alépée, Natalie; Bahinski, Anthony; Daneshian, Mardas; De Wever, Bart; Fritsche, Ellen; Goldberg, Alan; Hansmann, Jan; Hartung, Thomas; Haycock, John; Hogberg, Helena; Hoelting, Lisa; Kelm, Jens M; Kadereit, Suzanne; McVey, Emily; Landsiedel, Robert; Leis ALTEX. 25027500 2014;
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Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury. Esch, Mandy B; Mahler, Gretchen J; Stokol, Tracy; Shuler, Michael L Lab on a chip. 24970651 2014 Aug 21;
Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use. Nichols, Joan E; Niles, Jean A; Vega, Stephanie P; Argueta, Lissenya B; Eastaway, Adriene; Cortiella, Joaquin Experimental biology and medicine (Maywood, N.J.). 24962174 2014 Sep;
Using physiologically-based pharmacokinetic-guided ''body-on-a-chip'' systems to predict mammalian response to drug and chemical exposure. Sung, Jong Hwan; Srinivasan, Balaji; Esch, Mandy Brigitte; McLamb, William T; Bernabini, Catia; Shuler, Michael L; Hickman, James J Experimental biology and medicine (Maywood, N.J.). 24951471 2014 Sep;
Challenges and promises in modeling dermatologic disorders with bioengineered skin. Eungdamrong, Narat J; Higgins, Claire; Guo, Zongyou; Lee, Wen-Han; Gillette, Brian; Sia, Samuel; Christiano, Angela M Experimental biology and medicine (Maywood, N.J.). 24951469 2014 Sep;
Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide. Zhou, Hui-fang; Yan, Huimin; Hu, Ying; Springer, Luke E; Yang, Xiaoxia; Wickline, Samuel A; Pan, Dipanjan; Lanza, Gregory M; Pham, Christine T N ACS nano 24941020 2014 Jul 22
A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture. McCarty, William J; Usta, O Berk; Luitje, Martha; Bale, Shyam Sundhar; Bhushan, Abhinav; Hegde, Manjunath; Golberg, Inna; Jindal, Rohit; Yarmush, Martin L Technology. 24932459 2014 Mar;
Physiology and metabolism of tissue-engineered skeletal muscle. Cheng, Cindy S; Davis, Brittany N J; Madden, Lauran; Bursac, Nenad; Truskey, George A Experimental biology and medicine (Maywood, N.J.). 24912506 2014 Sep;
Biological and medical applications of a brain-on-a-chip. Pamies, David; Hartung, Thomas; Hogberg, Helena T Experimental biology and medicine (Maywood, N.J.). 24912505 2014 Sep;
Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers. Daily, Michael D; Olsen, Brett N; Schlesinger, Paul H; Ory, Daniel S; Baker, Nathan A Journal of chemical theory and computation. 24910542 2014 May 13;
A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro. Smith, A S T; Long, C J; Pirozzi, K; Najjar, S; McAleer, C; Vandenburgh, H H; Hickman, J J Journal of biotechnology. 24909944 2014 Sep 20;
Induced pluripotent stem cells for regenerative medicine. Hirschi, Karen K; Li, Song; Roy, Krishnendu Annual review of biomedical engineering. 24905879 2014 Jul 11;
Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems. Marasco, Christina C; Goodwin, Cody R; Winder, Danny G; Schramm-Sapyta, Nicole L; McLean, John A; Wikswo, John P Experimental biology and medicine (Maywood, N.J.). 24903164 2014 Nov;
Cellular and molecular mechanisms in kidney fibrosis. Duffield, Jeremy S The Journal of clinical investigation. 24892703 2014 Jun;
Phosphorylation of serine 106 in Asef2 regulates cell migration and adhesion turnover. Evans, J Corey; Hines, Kelly M; Forsythe, Jay G; Erdogan, Begum; Shi, Mingjian; Hill, Salisha; Rose, Kristie L; McLean, John A; Webb, Donna J Journal of proteome research. 24874604 2014 Jul 3;
Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury. Chen, Yi-Ting; Chang, Yu-Ting; Pan, Szu-Yu; Chou, Yu-Hsiang; Chang, Fan-Chi; Yeh, Pei-Ying; Liu, Yuan-Hung; Chiang, Wen-Chih; Chen, Yung-Ming; Wu, Kwan-Dun; Tsai, Tun-Jun; Duffield, Jeremy S; Lin, Shuei-Liong Journal of the American Society of Nephrology : JASN. 24854266 2014 Dec;
Ovarian cancer in endometriosis: clinical and molecular aspects. Lyttle, B; Bernardi, L; Pavone, M E Minerva ginecologica 24848074 2014 Apr
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Intracerebral hemorrhage mortality is not changing despite declining incidence. Zahuranec, Darin B; Lisabeth, Lynda D; Sanchez, Brisa N; Smith, Melinda A; Brown, Devin L; Garcia, Nelda M; Skolarus, Lesli E; Meurer, William J; Burke, James F; Adelman, Eric E; Morgenstern, Lewis B Neurology 24838789 2014 Jun 17
Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks. Zhao, Xuanhe Soft matter. 24834901 2014 Feb 7;
MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation. Bulte, Jeff W M; Schmieder, Anne H; Keupp, Jochen; Caruthers, Shelton D; Wickline, Samuel A; Lanza, Gregory M Nanomedicine : nanotechnology, biology, and medicine. 24832959 2014 Oct;
Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1?. Lin, Hang; Lozito, Thomas P; Alexander, Peter G; Gottardi, Riccardo; Tuan, Rocky S Molecular pharmaceutics. 24830762 2014 Jul 7;
Approaching the in vitro clinical trial: engineering organs on chips. Capulli, A K; Tian, K; Mehandru, N; Bukhta, A; Choudhury, S F; Suchyta, M; Parker, K K Lab on a chip. 24828385 2014 Sep 7;
A microphysiological system model of therapy for liver micrometastases. Clark, Amanda M; Wheeler, Sarah E; Taylor, Donald P; Pillai, Venkateswaran C; Young, Carissa L; Prantil-Baun, Rachelle; Nguyen, Transon; Stolz, Donna B; Borenstein, Jeffrey T; Lauffenburger, Douglas A; Venkataramanan, Raman; Griffith, Linda G; Wells, Alan Experimental biology and medicine (Maywood, N.J.). 24821820 2014 Sep;
Polymeric stent materials dysregulate macrophage and endothelial cell functions: implications for coronary artery stent. Wang, Xintong; Zachman, Angela L; Chun, Young Wook; Shen, Fang-Wen; Hwang, Yu-Shik; Sung, Hak-Joon International journal of cardiology. 24820736 2014 Jul 1;
Materials innovation for co-delivery of diverse therapeutic cargos. Godsey, Megan E; Suryaprakash, Smruthi; Leong, Kam W RSC advances. 24818000 2013 Dec 21;
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Wang, Gang; McCain, Megan L; Yang, Luhan; He, Aibin; Pasqualini, Francesco Silvio; Agarwal, Ashutosh; Yuan, Hongyan; Jiang, Dawei; Zhang, Donghui; Zangi, Lior; Geva, Judith; Roberts, Amy E; Ma, Qing; Ding, Jian; Chen, Jinghai; Wang, Da-Zhi; Li, Kai; Wang, Nature medicine. 24813252 2014 Jun;
Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. Puvenna, Vikram; Brennan, Chanda; Shaw, Gerald; Yang, Cui; Marchi, Nicola; Bazarian, Jeffrey J; Merchant-Borna, Kian; Janigro, Damir PloS one. 24806476 2014;
Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Ebrahimkhani, Mohammad R; Young, Carissa L; Lauffenburger, Douglas A; Griffith, Linda G; Borenstein, Jeffrey T Drug discovery today 24793141 2014 Jun
Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. Hartman, Kira G; Bortner Jr, James D; Falk, Gary W; Ginsberg, Gregory G; Jhala, Nirag; Yu, Jian; Martín, Martín G; Rustgi, Anil K; Lynch, John P Experimental biology and medicine (Maywood, N.J.). 24781339 2014 Sep;
Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform. Hegde, Manjunath; Jindal, Rohit; Bhushan, Abhinav; Bale, Shyam Sundhar; McCarty, William J; Golberg, Inna; Usta, O Berk; Yarmush, Martin L Lab on a chip. 24770663 2014 Jun 21;
Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research. Abrams, Julian A; Appelman, Henry D; Beer, David G; Berry, Lynne D; Chak, Amitabh; Falk, Gary W; Fitzgerald, Rebecca C; Ginsberg, Gregory G; Grady, William M; Joshi, Bishnu P; Lynch, John P; Markowitz, Sanford; Richmond, Ellen S; Rustgi, Anil K; Seibel, E Gastroenterology. 24768332 2014 Jun;
In vitro platforms for evaluating liver toxicity. Bale, Shyam Sundhar; Vernetti, Lawrence; Senutovitch, Nina; Jindal, Rohit; Hegde, Manjunath; Gough, Albert; McCarty, William J; Bakan, Ahmet; Bhushan, Abhinav; Shun, Tong Y; Golberg, Inna; DeBiasio, Richard; Usta, O Berk; Taylor, D Lansing; Yarmush, Marti Experimental biology and medicine (Maywood, N.J.). 24764241 2014 Sep;
A three-dimensional in vitro model of tumor cell intravasation. Ehsan, Seema M; Welch-Reardon, Katrina M; Waterman, Marian L; Hughes, Christopher C W; George, Steven C Integrative biology : quantitative biosciences from nano to macro. 24763498 2014 Jun;
Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKC? signaling. Cha, Boyoung; Chen, Tiane; Sarker, Rafiquel; Yang, Jianbo; Raben, Daniel; Tse, C Ming; Kovbasnjuk, Olga; Donowitz, Mark American journal of physiology. Cell physiology. 24760985 2014 Jul 1;
A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening. Heylman, Christopher; Sobrino, Agua; Shirure, Venktesh S; Hughes, Christopher Cw; George, Steven C Experimental biology and medicine (Maywood, N.J.). 24740872 2014 Sep;
Microphysiological modeling of the reproductive tract: A fertile endeavor. Eddie, Sharon L; Kim, J Julie; Woodruff, Teresa K; Burdette, Joanna E Experimental biology and medicine (Maywood, N.J.) 24737736 2014 Apr 15
Microscale technologies for regulating human stem cell differentiation. Cimetta, Elisa; Vunjak-Novakovic, Gordana Experimental biology and medicine (Maywood, N.J.). 24737735 2014 Sep;
Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. McCain, Megan L; Agarwal, Ashutosh; Nesmith, Haley W; Nesmith, Alexander P; Parker, Kevin Kit Biomaterials. 24731714 2014 Jul;
Integrating in vitro organ-specific function with the microcirculation. Moya, Monica L; George, Steven C Current opinion in chemical engineering. 24729953 2014 Feb 1;
Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using *(v)*ýýý-targeted theranostic nanoparticles. Pan, Dipanjan; Schmieder, Anne H; Wang, Kezheng; Yang, Xiaoxia; Senpan, Angana; Cui, Grace; Killgore, Kendall; Kim, Benjamin; Allen, John S; Zhang, Huiying; Caruthers, Shelton D; Shen, Baozhong; Wickline, Samuel A; Lanza, Gregory M Theranostics 24723979 2014
3D - a new dimension of in vitro research. Hartung, Thomas Advanced drug delivery reviews. 24721291 2014 Apr;
Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Foulke-Abel, Jennifer; In, Julie; Kovbasnjuk, Olga; Zachos, Nicholas C; Ettayebi, Khalil; Blutt, Sarah E; Hyser, Joseph M; Zeng, Xi-Lei; Crawford, Sue E; Broughman, James R; Estes, Mary K; Donowitz, Mark Experimental biology and medicine (Maywood, N.J.). 24719375 2014 Sep;
The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons. Kulangara, Karina; Adler, Andrew F; Wang, Hong; Chellappan, Malathi; Hammett, Ellen; Yasuda, Ryohei; Leong, Kam W Biomaterials. 24709523 2014 Jul;
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities. Smirnova, Lena; Hogberg, Helena T; Leist, Marcel; Hartung, Thomas ALTEX 24687333 2014
Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. McCain, Megan L; Yuan, Hongyan; Pasqualini, Francesco S; Campbell, Patrick H; Parker, Kevin Kit American journal of physiology. Heart and circulatory physiology. 24682394 2014 Jun 1;
Structural characterization of methylenedianiline regioisomers by ion mobility-mass spectrometry, tandem mass spectrometry, and computational strategies: I. Electrospray spectra of 2-ring isomers. Forsythe, Jay G; Stow, Sarah M; Nefzger, Hartmut; Kwiecien, Nicholas W; May, Jody C; McLean, John A; Hercules, David M Analytical chemistry. 24678803 2014 May 6;
Quality metrics for stem cell-derived cardiac myocytes. Sheehy, Sean P; Pasqualini, Francesco; Grosberg, Anna; Park, Sung Jin; Aratyn-Schaus, Yvonne; Parker, Kevin Kit Stem cell reports. 24672752 2014 Mar 11;
Engineering Liver. Griffith, Linda G; Wells, Alan; Stolz, Donna Beer Hepatology (Baltimore, Md.) 24668880 2014 Mar 26
Antagonizing the *v *3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading. Tomlinson, Ryan E; Schmieder, Anne H; Quirk, James D; Lanza, Gregory M; Silva, Matthew J Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 24644077 2014 Sep;
Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening. Zhao, Ruogang; Chen, Christopher S; Reich, Daniel H Biomaterials. 24630092 2014 Jun;
Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor. Diederichs, Solvig; Tuan, Rocky S Stem cells and development. 24625206 2014 Jul 15;
The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells. Ma, Bo; Wells, Alan The Journal of biological chemistry. 24619413 2014 Apr 18;
Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Taylor, Donald P; Clark, Amanda; Wheeler, Sarah; Wells, Alan Breast cancer research and treatment 24610032 2014 Apr
Bioreactor technologies to support liver function in vitro. Ebrahimkhani, Mohammad R; Neiman, Jaclyn A Shepard; Raredon, Micha Sam B; Hughes, David J; Griffith, Linda G Advanced drug delivery reviews 24607703 2014 Apr
Myocardial tissue engineering: in vitro models. Vunjak Novakovic, Gordana; Eschenhagen, Thomas; Mummery, Christine Cold Spring Harbor perspectives in medicine. 24591534 2014 Mar;
Cancer Stem Cells under Hypoxia as a Chemoresistance Factor in Breast and Brain. Crowder, Spencer W; Balikov, Daniel A; Hwang, Yu-Shik; Sung, Hak-Joon Current pathobiology reports. 24587979 2014 Mar;
Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution. Lin, Hang; Cheng, Anthony Wai-Ming; Alexander, Peter G; Beck, Angela M; Tuan, Rocky S Tissue engineering. Part A. 24575844 2014 Sep;
Three-dimensional paper-based model for cardiac ischemia. Mosadegh, Bobak; Dabiri, Borna E; Lockett, Matthew R; Derda, Ratmir; Campbell, Patrick; Parker, Kevin Kit; Whitesides, George M Advanced healthcare materials. 24574054 2014 Jul;
Mouse liver repopulation with hepatocytes generated from human fibroblasts. Zhu, Saiyong; Rezvani, Milad; Harbell, Jack; Mattis, Aras N; Wolfe, Alan R; Benet, Leslie Z; Willenbring, Holger; Ding, Sheng Nature. 24572354 2014 Apr 3;
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. Bhushan, Abhinav; Senutovitch, Nina; Bale, Shyam S; McCarty, William J; Hegde, Manjunath; Jindal, Rohit; Golberg, Inna; Berk Usta, O; Yarmush, Martin L; Vernetti, Lawrence; Gough, Albert; Bakan, Ahmet; Shun, Tong Ying; DeBiasio, Richard; Lansing Taylor, D Stem cell research & therapy. 24565476 2013;
An integrated in vitro model of perfused tumor and cardiac tissue. Moya, Monica; Tran, David; George, Steven C Stem cell research & therapy. 24565445 2013;
Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. Mathur, Anurag; Loskill, Peter; Hong, Soongweon; Lee, Jae; Marcus, Sivan G; Dumont, Laure; Conklin, Bruce R; Willenbring, Holger; Lee, Luke P; Healy, Kevin E Stem cell research & therapy. 24565415 2013;
Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment. Laronda, Monica M; Burdette, Joanna E; Kim, J; Woodruff, Teresa K Stem cell research & therapy 24565375 2013
A human pluripotent stem cell platform for assessing developmental neural toxicity screening. Hou, Zhonggang; Zhang, Jue; Schwartz, Michael P; Stewart, Ron; Page, C David; Murphy, William L; Thomson, James A Stem cell research & therapy. 24565336 2013;
All-human microphysical model of metastasis therapy. Wheeler, Sarah E; Borenstein, Jeffrey T; Clark, Amanda M; Ebrahimkhani, Mohammad R; Fox, Ira J; Griffith, Linda; Inman, Walker; Lauffenburger, Douglas; Nguyen, Transon; Pillai, Venkateswaran C; Prantil-Baun, Rachelle; Stolz, Donna B; Taylor, Donald; Ulric Stem cell research & therapy. 24565274 2013;
Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Truskey, George A; Achneck, Hardean E; Bursac, Nenad; Chan, Hon; Cheng, Cindy S; Fernandez, Cristina; Hong, Sungmin; Jung, Youngmee; Koves, Tim; Kraus, William E; Leong, Kam; Madden, Lauran; Reichert, William M; Zhao, Xuanhe Stem cell research & therapy. 24565225 2013;
Building additional complexity to in vitro-derived intestinal tissues. Brugmann, Samantha A; Wells, James M Stem cell research & therapy. 24565179 2013;
Microphysiological systems and low-cost microfluidic platform with analytics. Smith, Alec S T; Long, Christopher J; Berry, Bonnie J; McAleer, Christopher; Stancescu, Maria; Molnar, Peter; Miller, Paula G; Esch, Mandy B; Prot, Jean-Matthieu; Hickman, James J; Shuler, Michael L Stem cell research & therapy. 24565109 2013;
HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Vunjak-Novakovic, Gordana; Bhatia, Sangeeta; Chen, Christopher; Hirschi, Karen Stem cell research & therapy 24565063 2013
Novel in vitro respiratory models to study lung development, physiology, pathology and toxicology. Nichols, Joan E; Niles, Jean A; Vega, Stephanie P; Cortiella, Joaquin Stem cell research & therapy. 24565038 2013;
Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. Lozito, Thomas P; Alexander, Peter G; Lin, Hang; Gottardi, Riccardo; Cheng, Anthony Wai-Ming; Tuan, Rocky S Stem cell research & therapy. 24564995 2013;
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. Hartman, Kira G; Bortner, James D; Falk, Gary W; Yu, Jian; Martín, Martín G; Rustgi, Anil K; Lynch, John P Stem cell research & therapy. 24564965 2013;
Toward a 3D model of human brain development for studying gene/environment interactions. Hogberg, Helena T; Bressler, Joseph; Christian, Kimberly M; Harris, Georgina; Makri, Georgia; O'Driscoll, Cliona; Pamies, David; Smirnova, Lena; Wen, Zhexing; Hartung, Thomas Stem cell research & therapy. 24564953 2013;
Human enteroids: preclinical models of non-inflammatory diarrhea. Kovbasnjuk, Olga; Zachos, Nicholas C; In, Julie; Foulke-Abel, Jennifer; Ettayebi, Khalil; Hyser, Joseph M; Broughman, James R; Zeng, Xi-Lei; Middendorp, Sabine; de Jonge, Hugo R; Estes, Mary K; Donowitz, Mark Stem cell research & therapy. 24564938 2013;
Building a microphysiological skin model from induced pluripotent stem cells. Guo, Zongyou; Higgins, Claire A; Gillette, Brian M; Itoh, Munenari; Umegaki, Noriko; Gledhill, Karl; Sia, Samuel K; Christiano, Angela M Stem cell research & therapy. 24564920 2013;
Neurovascular unit on a chip: implications for translational applications. Alcendor, Donald J; Block 3rd, Frank E; Cliffel, David E; Daniels, John Scott; Ellacott, Kate L J; Goodwin, Cody R; Hofmeister, Lucas H; Li, Deyu; Markov, Dmitry A; May, Jody C; McCawley, Lisa J; McLaughlin, BethAnn; McLean, John A; Niswender, Kevin D; Pe Stem cell research & therapy. 24564885 2013;
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Kelly, Edward J; Wang, Zhican; Voellinger, Jenna L; Yeung, Cathy K; Shen, Danny D; Thummel, Kenneth E; Zheng, Ying; Ligresti, Giovanni; Eaton, David L; Muczynski, Kimberly A; Duffield, Jeremy S; Neumann, Thomas; Tourovskaia, Anna; Fauver, Mark; Kramer, Gr Stem cell research & therapy. 24564863 2013;
Annotating the structure and components of a nanoparticle formulation using computable string expressions. Thomas, Dennis G; Chikkagoudar, Satish; Chappell, Alan R; Baker, Nathan A Proceedings. IEEE International Conference on Bioinformatics and Biomedicine. 24533226 2012 Dec 31;
Biological and engineering design considerations for vascular tissue engineered blood vessels (TEBVs). Fernandez, Cristina E; Achneck, Hardean E; Reichert, William M; Truskey, George A Current opinion in chemical engineering. 24511460 2014 Feb 1;
Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Li, Cheri Yingjie; Stevens, Kelly R; Schwartz, Robert E; Alejandro, Brian Steven; Huang, Joanne H; Bhatia, Sangeeta N Tissue engineering. Part A 24498910 2014 Feb 5
Physical influences on stem cells. Vunjak-Novakovic, Gordana Stem cell research & therapy. 24476419 2013;
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