Regulatory Science
Regulatory Science
Program Publications
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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.
| Title | Author | Journal Name | PubMedID | Journal Abbreviation | Publication Date | PubMedLink |
|---|---|---|---|---|---|---|
| Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening. | Xu Y, Duncan FE, Xu M, Woodruff TK | Reproduction, fertility, and development | 25689754 | Reprod Fertil Dev | 2015 Feb 18 | https://www.ncbi.nlm.nih.gov/pubmed/25689754 |
| A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells. | Stranford DM, Hung ME, Gargus ES, Shah RN, Leonard JN | Tissue engineering. Part A | 28586292 | Tissue Eng Part A | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/28586292 |
| A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. | Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN | Nature communications | 28509899 | Nat Commun | 2017 May 16 | https://www.ncbi.nlm.nih.gov/pubmed/28509899 |
| Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators. | Moyle-Heyrman G, Schipma MJ, Dean M, Davis DA, Burdette JE | Journal of ovarian research | 26879975 | J Ovarian Res | 2016 Feb 15 | https://www.ncbi.nlm.nih.gov/pubmed/26879975 |
| Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids. | Edmonds ME, Forshee MD, Woodruff TK | Journal of visualized experiments : JoVE | 33104061 | J Vis Exp | 2020 Oct 7 | https://www.ncbi.nlm.nih.gov/pubmed/33104061 |
| Engineered reproductive tissues. | Gargus ES, Rogers HB, McKinnon KE, Edmonds ME, Woodruff TK | Nature biomedical engineering | 32251392 | Nat Biomed Eng | 2020 Apr | https://www.ncbi.nlm.nih.gov/pubmed/32251392 |
| A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. | Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK | Nature communications | 28350383 | Nat Commun | 2017 Mar 28 | https://www.ncbi.nlm.nih.gov/pubmed/28350383 |
| Novel three dimensional human endocervix cultures respond to 28-day hormone treatment. | Arslan SY, Yu Y, Burdette JE, Pavone ME, Hope TJ, Woodruff TK, Kim JJ | Endocrinology | 25635622 | Endocrinology | 2015 Apr | https://www.ncbi.nlm.nih.gov/pubmed/25635622 |
| Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface. | Karthikeyan S, Lantvit DD, Chae DH, Burdette JE | Oncotarget | 27563818 | Oncotarget | 2016 Oct 25 | https://www.ncbi.nlm.nih.gov/pubmed/27563818 |
| Three-dimensional modeling of the human fallopian tube fimbriae. | Eddie SL, Quartuccio SM, Zhu J, Shepherd JA, Kothari R, Kim JJ, Woodruff TK, Burdette JE | Gynecologic oncology | 25527363 | Gynecol Oncol | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25527363 |
| Microphysiologic systems in female reproductive biology. | Young AN, Moyle-Heyrman G, Kim JJ, Burdette JE | Experimental biology and medicine (Maywood, N.J.) | 29065798 | Exp Biol Med (Maywood) | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/29065798 |
| Doxorubicin Has Dose-Dependent Toxicity on Mouse Ovarian Follicle Development, Hormone Secretion, and Oocyte Maturation. | Xiao S, Zhang J, Liu M, Iwahata H, Rogers HB, Woodruff TK | Toxicological sciences : an official journal of the Society of Toxicology | 28329872 | Toxicol Sci | 2017 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/28329872 |
| Engineering the ovarian cycle using in vitro follicle culture. | Skory RM, Xu Y, Shea LD, Woodruff TK | Human reproduction (Oxford, England) | 25784584 | Hum Reprod | 2015 Jun | https://www.ncbi.nlm.nih.gov/pubmed/25784584 |
| Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase. | McKinnon KE, Getsios S, Woodruff TK | Biology of reproduction | 32614039 | Biol Reprod | 2020 Aug 21 | https://www.ncbi.nlm.nih.gov/pubmed/32614039 |
| A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control. | Coppeta JR, Mescher MJ, Isenberg BC, Spencer AJ, Kim ES, Lever AR, Mulhern TJ, Prantil-Baun R, Comolli JC, Borenstein JT | Lab on a chip | 27901159 | Lab Chip | 2016 Dec 20 | https://www.ncbi.nlm.nih.gov/pubmed/27901159 |
| Initiation of puberty in mice following decellularized ovary transplant. | Laronda MM, Jakus AE, Whelan KA, Wertheim JA, Shah RN, Woodruff TK | Biomaterials | 25736492 | Biomaterials | 2015 May | https://www.ncbi.nlm.nih.gov/pubmed/25736492 |
| Good manufacturing practice requirements for the production of tissue vitrification and warming and recovery kits for clinical research. | Laronda MM, McKinnon KE, Ting AY, Le Fever AV, Zelinski MB, Woodruff TK | Journal of assisted reproduction and genetics | 27900615 | J Assist Reprod Genet | 2017 Feb | https://www.ncbi.nlm.nih.gov/pubmed/27900615 |
| Testicular organoid formation is a property of immature somatic cells, which self-assemble and exhibit long-term hormone-responsive endocrine function. | Edmonds ME, Woodruff TK | Biofabrication | 32492667 | Biofabrication | 2020 Jul 9 | https://www.ncbi.nlm.nih.gov/pubmed/32492667 |
| Endometriosis and ovarian cancer: links, risks, and challenges faced. | Pavone ME, Lyttle BM | International journal of women's health | 26170722 | Int J Womens Health | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26170722 |
| Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle. | Zhu J, Xu Y, Rashedi AS, Pavone ME, Kim JJ, Woodruff TK, Burdette JE | Molecular human reproduction | 27542947 | Mol Hum Reprod | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/27542947 |
| Multidrug Resistance Protein 1 Deficiency Promotes Doxorubicin-Induced Ovarian Toxicity in Female Mice. | Wang Y, Liu M, Zhang J, Liu Y, Kopp M, Zheng W, Xiao S | Toxicological sciences : an official journal of the Society of Toxicology | 29462422 | Toxicol Sci | 2018 May 1 | https://www.ncbi.nlm.nih.gov/pubmed/29462422 |
| Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions. | Yuan H, Marzban B, Kit Parker K | Journal of biomechanical engineering | 28857113 | J Biomech Eng | 2017 Dec 1 | https://www.ncbi.nlm.nih.gov/pubmed/28857113 |
| A tissue-engineered scale model of the heart ventricle. | MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK | Nature biomedical engineering | 31015723 | Nat Biomed Eng | 2018 Dec | https://www.ncbi.nlm.nih.gov/pubmed/31015723 |
| Acute pergolide exposure stiffens engineered valve interstitial cell tissues and reduces contractility in vitro. | Capulli AK, MacQueen LA, O'Connor BB, Dauth S, Parker KK | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology | 27174867 | Cardiovasc Pathol | 2016 Jul-Aug | https://www.ncbi.nlm.nih.gov/pubmed/27174867 |
| Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening. | Lind JU, Yadid M, Perkins I, O'Connor BB, Eweje F, Chantre CO, Hemphill MA, Yuan H, Campbell PH, Vlassak JJ, Parker KK | Lab on a chip | 28976521 | Lab Chip | 2017 Oct 25 | https://www.ncbi.nlm.nih.gov/pubmed/28976521 |
| Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. | McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK | American journal of physiology. Heart and circulatory physiology | 24682394 | Am J Physiol Heart Circ Physiol | 2014 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/24682394 |
| Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. | Malladi S, Miranda-Nieves D, Leng L, Grainger SJ, Tarabanis C, Nesmith AP, Kosaraju R, Haller CA, Parker KK, Chaikof EL, Günther A | ACS biomaterials science & engineering | 32685675 | ACS Biomater Sci Eng | 2020 Jul 13 | https://www.ncbi.nlm.nih.gov/pubmed/32685675 |
| Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip. | Yadid M, Lind JU, Ardoña HAM, Sheehy SP, Dickinson LE, Eweje F, Bastings MMC, Pope B, O'Connor BB, Straubhaar JR, Budnik B, Kleber AG, Parker KK | Science translational medicine | 33055246 | Sci Transl Med | 2020 Oct 14 | https://www.ncbi.nlm.nih.gov/pubmed/33055246 |
| Quality metrics for stem cell-derived cardiac myocytes. | Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK | Stem cell reports | 24672752 | Stem Cell Reports | 2014 Mar 11 | https://www.ncbi.nlm.nih.gov/pubmed/24672752 |
| Three-dimensional paper-based model for cardiac ischemia. | Mosadegh B, Dabiri BE, Lockett MR, Derda R, Campbell P, Parker KK, Whitesides GM | Advanced healthcare materials | 24574054 | Adv Healthc Mater | 2014 Jul | https://www.ncbi.nlm.nih.gov/pubmed/24574054 |
| Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. | Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK | The Journal of cell biology | 26858266 | J Cell Biol | 2016 Feb 15 | https://www.ncbi.nlm.nih.gov/pubmed/26858266 |
| Angiotensin II Induced Cardiac Dysfunction on a Chip. | Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK | PloS one | 26808388 | PLoS One | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/26808388 |
| Organ Chips: Quality Assurance Systems in Regenerative Medicine. | Pasqualini FS, Emmert MY, Parker KK, Hoerstrup SP | Clinical pharmacology and therapeutics | 27709615 | Clin Pharmacol Ther | 2017 Jan | https://www.ncbi.nlm.nih.gov/pubmed/27709615 |
| Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. | Lind JU, Busbee TA, Valentine AD, Pasqualini FS, Yuan H, Yadid M, Park SJ, Kotikian A, Nesmith AP, Campbell PH, Vlassak JJ, Lewis JA, Parker KK | Nature materials | 27775708 | Nat Mater | 2017 Mar | https://www.ncbi.nlm.nih.gov/pubmed/27775708 |
| Traction force microscopy of engineered cardiac tissues. | Pasqualini FS, Agarwal A, O'Connor BB, Liu Q, Sheehy SP, Parker KK | PloS one | 29590169 | PLoS One | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29590169 |
| The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function. | Ye GJ, Nesmith AP, Parker KK | Anatomical record (Hoboken, N.J. : 2007) | 25125187 | Anat Rec (Hoboken) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/25125187 |
| Structural phenotyping of stem cell-derived cardiomyocytes. | Pasqualini FS, Sheehy SP, Agarwal A, Aratyn-Schaus Y, Parker KK | Stem cell reports | 25733020 | Stem Cell Reports | 2015 Mar 10 | https://www.ncbi.nlm.nih.gov/pubmed/25733020 |
| Phototactic guidance of a tissue-engineered soft-robotic ray. | Park SJ, Gazzola M, Park KS, Park S, Di Santo V, Blevins EL, Lind JU, Campbell PH, Dauth S, Capulli AK, Pasqualini FS, Ahn S, Cho A, Yuan H, Maoz BM, Vijaykumar R, Choi JW, Deisseroth K, Lauder GV, Mahadevan L, Parker KK | Science (New York, N.Y.) | 27387948 | Science | 2016 Jul 8 | https://www.ncbi.nlm.nih.gov/pubmed/27387948 |
| JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement. | Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP, Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK | Biomaterials | 28445803 | Biomaterials | 2017 Jul | https://www.ncbi.nlm.nih.gov/pubmed/28445803 |
| Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. | McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK | Proceedings of the National Academy of Sciences of the United States of America | 23716679 | Proc Natl Acad Sci U S A | 2013 Jun 11 | https://www.ncbi.nlm.nih.gov/pubmed/23716679 |
| Mechanotransduction and Metabolism in Cardiomyocyte Microdomains. | Pasqualini FS, Nesmith AP, Horton RE, Sheehy SP, Parker KK | BioMed research international | 28044126 | Biomed Res Int | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/28044126 |
| Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. | Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK | Circulation | 31311300 | Circulation | 2019 Jul 30 | https://www.ncbi.nlm.nih.gov/pubmed/31311300 |
| Recreating the heart's helical structure-function relationship with focused rotary jet spinning. | Chang H, Liu Q, Zimmerman JF, Lee KY, Jin Q, Peters MM, Rosnach M, Choi S, Kim SL, Ardoña HAM, MacQueen LA, Chantre CO, Motta SE, Cordoves EM, Parker KK | Science (New York, N.Y.) | 35857545 | Science | 2022 Jul 8 | https://www.ncbi.nlm.nih.gov/pubmed/35857545 |
| Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. | McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK | Biomaterials | 24731714 | Biomaterials | 2014 Jul | https://www.ncbi.nlm.nih.gov/pubmed/24731714 |
| Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. | Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT | Nature medicine | 24813252 | Nat Med | 2014 Jun | https://www.ncbi.nlm.nih.gov/pubmed/24813252 |
| Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. | Nesmith AP, Agarwal A, McCain ML, Parker KK | Lab on a chip | 25093641 | Lab Chip | 2014 Oct 21 | https://www.ncbi.nlm.nih.gov/pubmed/25093641 |
| Approaching the in vitro clinical trial: engineering organs on chips. | Capulli AK, Tian K, Mehandru N, Bukhta A, Choudhury SF, Suchyta M, Parker KK | Lab on a chip | 24828385 | Lab Chip | 2014 Sep 7 | https://www.ncbi.nlm.nih.gov/pubmed/24828385 |
| Fibrous scaffolds for building hearts and heart parts. | Capulli AK, MacQueen LA, Sheehy SP, Parker KK | Advanced drug delivery reviews | 26656602 | Adv Drug Deliv Rev | 2016 Jan 15 | https://www.ncbi.nlm.nih.gov/pubmed/26656602 |
| Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications. | Nawroth JC, Scudder LL, Halvorson RT, Tresback J, Ferrier JP, Sheehy SP, Cho A, Kannan S, Sunyovszki I, Goss JA, Campbell PH, Parker KK | Biofabrication | 29337695 | Biofabrication | 2018 Jan 16 | https://www.ncbi.nlm.nih.gov/pubmed/29337695 |
| An autonomously swimming biohybrid fish designed with human cardiac biophysics. | Lee KY, Park SJ, Matthews DG, Kim SL, Marquez CA, Zimmerman JF, Ardoña HAM, Kleber AG, Lauder GV, Parker KK | Science (New York, N.Y.) | 35143298 | Science | 2022 Feb 11 | https://www.ncbi.nlm.nih.gov/pubmed/35143298 |
| Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. | Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen L, Bezzerides VJ, Parker KK, Melton DA, Lee RT | Circulation | 31707831 | Circulation | 2020 Jan 28 | https://www.ncbi.nlm.nih.gov/pubmed/31707831 |
| Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin. | Pellett S, Schwartz MP, Tepp WH, Josephson R, Scherf JM, Pier CL, Thomson JA, Murphy WL, Johnson EA | Scientific reports | 26411797 | Sci Rep | 2015 Sep 28 | https://www.ncbi.nlm.nih.gov/pubmed/26411797 |
| A Genome-wide Analysis of Human Pluripotent Stem Cell-Derived Endothelial Cells in 2D or 3D Culture. | Zhang J, Schwartz MP, Hou Z, Bai Y, Ardalani H, Swanson S, Steill J, Ruotti V, Elwell A, Nguyen BK, Bolin J, Stewart R, Thomson JA, Murphy WL | Stem cell reports | 28343999 | Stem Cell Reports | 2017 Apr 11 | https://www.ncbi.nlm.nih.gov/pubmed/28343999 |
| A statistical approach for identifying differential distributions in single-cell RNA-seq experiments. | Korthauer KD, Chu LF, Newton MA, Li Y, Thomson J, Stewart R, Kendziorski C | Genome biology | 27782827 | Genome Biol | 2016 Oct 25 | https://www.ncbi.nlm.nih.gov/pubmed/27782827 |
| Biofunctionalized Plants as Diverse Biomaterials for Human Cell Culture. | Fontana G, Gershlak J, Adamski M, Lee JS, Matsumoto S, Le HD, Binder B, Wirth J, Gaudette G, Murphy WL | Advanced healthcare materials | 28319334 | Adv Healthc Mater | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/28319334 |
| Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications. | Adamski M, Fontana G, Gershlak JR, Gaudette GR, Le HD, Murphy WL | Journal of visualized experiments : JoVE | 29912197 | J Vis Exp | 2018 May 31 | https://www.ncbi.nlm.nih.gov/pubmed/29912197 |
| Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics. | Barry C, Schmitz MT, Argus C, Bolin JM, Probasco MD, Leng N, Duffin BM, Steill J, Swanson S, McIntosh BE, Stewart R, Kendziorski C, Thomson JA, Bacher R | PLoS computational biology | 31815944 | PLoS Comput Biol | 2019 Dec | https://www.ncbi.nlm.nih.gov/pubmed/31815944 |
| Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and nontumorigenic human mesenchymal cell types. | Hansen TD, Koepsel JT, Le NN, Nguyen EH, Zorn S, Parlato M, Loveland SG, Schwartz MP, Murphy WL | Biomaterials science | 25386339 | Biomater Sci | 2014 May | https://www.ncbi.nlm.nih.gov/pubmed/25386339 |
| Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. | Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL | Acta biomaterialia | 26945632 | Acta Biomater | 2016 Apr 15 | https://www.ncbi.nlm.nih.gov/pubmed/26945632 |
| A human pluripotent stem cell platform for assessing developmental neural toxicity screening. | Hou Z, Zhang J, Schwartz MP, Stewart R, Page CD, Murphy WL, Thomson JA | Stem cell research & therapy | 24565336 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565336 |
| Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques. | Barry C, Schmitz MT, Propson NE, Hou Z, Zhang J, Nguyen BK, Bolin JM, Jiang P, McIntosh BE, Probasco MD, Swanson S, Stewart R, Thomson JA, Schwartz MP, Murphy WL | Experimental biology and medicine (Maywood, N.J.) | 28599598 | Exp Biol Med (Maywood) | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/28599598 |
| Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. | Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP, Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB, Sheibani N, Murphy WL | Nature biomedical engineering | 29104816 | Nat Biomed Eng | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/29104816 |
| Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments. | Leng N, Chu LF, Barry C, Li Y, Choi J, Li X, Jiang P, Stewart RM, Thomson JA, Kendziorski C | Nature methods | 26301841 | Nat Methods | 2015 Oct | https://www.ncbi.nlm.nih.gov/pubmed/26301841 |
| An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells. | Chu LF, Mamott D, Ni Z, Bacher R, Liu C, Swanson S, Kendziorski C, Stewart R, Thomson JA | Cell reports | 31461642 | Cell Rep | 2019 Aug 27 | https://www.ncbi.nlm.nih.gov/pubmed/31461642 |
| Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. | Le NNT, Zorn S, Schmitt SK, Gopalan P, Murphy WL | Acta biomaterialia | 26386315 | Acta Biomater | 2016 Apr 1 | https://www.ncbi.nlm.nih.gov/pubmed/26386315 |
| Species-specific developmental timing is maintained by pluripotent stem cells ex utero. | Barry C, Schmitz MT, Jiang P, Schwartz MP, Duffin BM, Swanson S, Bacher R, Bolin JM, Elwell AL, McIntosh BE, Stewart R, Thomson JA | Developmental biology | 28179190 | Dev Biol | 2017 Mar 15 | https://www.ncbi.nlm.nih.gov/pubmed/28179190 |
| A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia. | Zhang J, McIntosh BE, Wang B, Brown ME, Probasco MD, Webster S, Duffin B, Zhou Y, Guo LW, Burlingham WJ, Kent C, Ferris M, Thomson JA | Stem cell reports | 31080110 | Stem Cell Reports | 2019 Jun 11 | https://www.ncbi.nlm.nih.gov/pubmed/31080110 |
| Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays. | Nguyen EH, Zanotelli MR, Schwartz MP, Murphy WL | Biomaterials | 24332391 | Biomaterials | 2014 Feb | https://www.ncbi.nlm.nih.gov/pubmed/24332391 |
| Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. | Hou Z, Zhang Y, Propson NE, Howden SE, Chu LF, Sontheimer EJ, Thomson JA | Proceedings of the National Academy of Sciences of the United States of America | 23940360 | Proc Natl Acad Sci U S A | 2013 Sep 24 | https://www.ncbi.nlm.nih.gov/pubmed/23940360 |
| A cost-effective RNA sequencing protocol for large-scale gene expression studies. | Hou Z, Jiang P, Swanson SA, Elwell AL, Nguyen BK, Bolin JM, Stewart R, Thomson JA | Scientific reports | 25831155 | Sci Rep | 2015 Apr 1 | https://www.ncbi.nlm.nih.gov/pubmed/25831155 |
| Machine learning to predict developmental neurotoxicity with high-throughput data from 2D bio-engineered tissues. | Kuusisto F, Costa VS, Hou Z, Thomson J, Page D, Stewart R | Proceedings of the ... International Conference on Machine Learning and Applications. International Conference on Machine Learning and Applications | 32181450 | Proc Int Conf Mach Learn Appl | 2019 Dec | https://www.ncbi.nlm.nih.gov/pubmed/32181450 |
| OEFinder: a user interface to identify and visualize ordering effects in single-cell RNA-seq data. | Leng N, Choi J, Chu LF, Thomson JA, Kendziorski C, Stewart R | Bioinformatics (Oxford, England) | 26743507 | Bioinformatics | 2016 May 1 | https://www.ncbi.nlm.nih.gov/pubmed/26743507 |
| Customizable biomaterials as tools for advanced anti-angiogenic drug discovery. | Nguyen EH, Murphy WL | Biomaterials | 30077137 | Biomaterials | 2018 Oct | https://www.ncbi.nlm.nih.gov/pubmed/30077137 |
| Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels. | Kaushik G, Gil DA, Torr E, Berge ES, Soref C, Uhl P, Fontana G, Antosiewicz-Bourget J, Edington C, Schwartz MP, Griffith LG, Thomson JA, Skala MC, Daly WT, Murphy WL | Advanced healthcare materials | 30565891 | Adv Healthc Mater | 2019 Jan | https://www.ncbi.nlm.nih.gov/pubmed/30565891 |
| Trendy: segmented regression analysis of expression dynamics in high-throughput ordered profiling experiments. | Bacher R, Leng N, Chu LF, Ni Z, Thomson JA, Kendziorski C, Stewart R | BMC bioinformatics | 30326833 | BMC Bioinformatics | 2018 Oct 16 | https://www.ncbi.nlm.nih.gov/pubmed/30326833 |
| RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. | Jiang P, Hou Z, Bolin JM, Thomson JA, Stewart R | Toxicological sciences : an official journal of the Society of Toxicology | 28903495 | Toxicol Sci | 2017 Sep 1 | https://www.ncbi.nlm.nih.gov/pubmed/28903495 |
| TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes. | Jiang P, Chamberlain CS, Vanderby R, Thomson JA, Stewart R | Nucleic acids research | 32123905 | Nucleic Acids Res | 2020 May 21 | https://www.ncbi.nlm.nih.gov/pubmed/32123905 |
| Network inference with Granger causality ensembles on single-cell transcriptomics. | Deshpande A, Chu LF, Stewart R, Gitter A | Cell reports | 35139376 | Cell Rep | 2022 Feb 8 | https://www.ncbi.nlm.nih.gov/pubmed/35139376 |
| Interspecies chimeric conditions affect the developmental rate of human pluripotent stem cells. | Brown J, Barry C, Schmitz MT, Argus C, Bolin JM, Schwartz MP, Van Aartsen A, Steill J, Swanson S, Stewart R, Thomson JA, Kendziorski C | PLoS computational biology | 33647016 | PLoS Comput Biol | 2021 Mar | https://www.ncbi.nlm.nih.gov/pubmed/33647016 |
| Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling. | Mina SG, Alaybeyoglu B, Murphy WL, Thomson JA, Stokes CL, Cirit M | Frontiers in big data | 33693346 | Front Big Data | 2019 | https://www.ncbi.nlm.nih.gov/pubmed/33693346 |
| Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. | Schwartz MP, Hou Z, Propson NE, Zhang J, Engstrom CJ, Santos Costa V, Jiang P, Nguyen BK, Bolin JM, Daly W, Wang Y, Stewart R, Page CD, Murphy WL, Thomson JA | Proceedings of the National Academy of Sciences of the United States of America | 26392547 | Proc Natl Acad Sci U S A | 2015 Oct 6 | https://www.ncbi.nlm.nih.gov/pubmed/26392547 |
| Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. | Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL | Stem cell reviews and reports | 25190668 | Stem Cell Rev Rep | 2015 Jun | https://www.ncbi.nlm.nih.gov/pubmed/25190668 |
| Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm. | Chu LF, Leng N, Zhang J, Hou Z, Mamott D, Vereide DT, Choi J, Kendziorski C, Stewart R, Thomson JA | Genome biology | 27534536 | Genome Biol | 2016 Aug 17 | https://www.ncbi.nlm.nih.gov/pubmed/27534536 |
| Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. | Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S, Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, Burlingham WJ, Murphy WL, Thomson JA | Proceedings of the National Academy of Sciences of the United States of America | 28696312 | Proc Natl Acad Sci U S A | 2017 Jul 25 | https://www.ncbi.nlm.nih.gov/pubmed/28696312 |
| Enabling functional genomics with genome engineering. | Hilton IB, Gersbach CA | Genome research | 26430154 | Genome Res | 2015 Oct | https://www.ncbi.nlm.nih.gov/pubmed/26430154 |
| A CRISPR/Cas9-based system for reprogramming cell lineage specification. | Chakraborty S, Ji H, Kabadi AM, Gersbach CA, Christoforou N, Leong KW | Stem cell reports | 25448066 | Stem Cell Reports | 2014 Dec 9 | https://www.ncbi.nlm.nih.gov/pubmed/25448066 |
| Nanograting structure promotes lamellipodia-based cell collective migration and wound healing. | Chen Z, Atchison L, Ji H, Leong KW | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 25570601 | Annu Int Conf IEEE Eng Med Biol Soc | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25570601 |
| Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy. | Ousterout DG, Kabadi AM, Thakore PI, Majoros WH, Reddy TE, Gersbach CA | Nature communications | 25692716 | Nat Commun | 2015 Feb 18 | https://www.ncbi.nlm.nih.gov/pubmed/25692716 |
| Nanotopography alters nuclear protein expression, proliferation and differentiation of human mesenchymal stem/stromal cells. | Kulangara K, Yang J, Chellappan M, Yang Y, Leong KW | PloS one | 25521962 | PLoS One | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25521962 |
| Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts. | Xing Q, Vogt C, Leong KW, Zhao F | Advanced functional materials | 25484849 | Adv Funct Mater | 2014 May 28 | https://www.ncbi.nlm.nih.gov/pubmed/25484849 |
| Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. | Ousterout DG, Kabadi AM, Thakore PI, Perez-Pinera P, Brown MT, Majoros WH, Reddy TE, Gersbach CA | Molecular therapy : the journal of the American Society of Gene Therapy | 25492562 | Mol Ther | 2015 Mar | https://www.ncbi.nlm.nih.gov/pubmed/25492562 |
| Engineering mesenchymal stem cells for regenerative medicine and drug delivery. | Park JS, Suryaprakash S, Lao YH, Leong KW | Methods (San Diego, Calif.) | 25770356 | Methods | 2015 Aug | https://www.ncbi.nlm.nih.gov/pubmed/25770356 |
| Integration of drug, protein, and gene delivery systems with regenerative medicine. | Lorden ER, Levinson HM, Leong KW | Drug delivery and translational research | 25787742 | Drug Deliv Transl Res | 2015 Apr | https://www.ncbi.nlm.nih.gov/pubmed/25787742 |
| Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles. | Davis BNJ, Santoso JW, Walker MJ, Oliver CE, Cunningham MM, Boehm CA, Dawes D, Lasater SL, Huffman K, Kraus WE, Truskey GA | Annals of biomedical engineering | 30963383 | Ann Biomed Eng | 2019 Jul | https://www.ncbi.nlm.nih.gov/pubmed/30963383 |
| A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells. | Atchison L, Zhang H, Cao K, Truskey GA | Scientific reports | 28811655 | Sci Rep | 2017 Aug 15 | https://www.ncbi.nlm.nih.gov/pubmed/28811655 |
| Bursting drops in solid dielectrics caused by high voltages. | Wang Q, Suo Z, Zhao X | Nature communications | 23093194 | Nat Commun | 2012 | https://www.ncbi.nlm.nih.gov/pubmed/23093194 |
| Biological and engineering design considerations for vascular tissue engineered blood vessels (TEBVs). | Fernandez CE, Achneck HE, Reichert WM, Truskey GA | Current opinion in chemical engineering | 24511460 | Curr Opin Chem Eng | 2014 Feb 1 | https://www.ncbi.nlm.nih.gov/pubmed/24511460 |
| Engineering skeletal muscle repair. | Juhas M, Bursac N | Current opinion in biotechnology | 23711735 | Curr Opin Biotechnol | 2013 Oct | https://www.ncbi.nlm.nih.gov/pubmed/23711735 |
| Oxygen consumption in human, tissue-engineered myobundles during basal and electrical stimulation conditions. | Davis BN, Yen R, Prasad V, Truskey GA | APL bioengineering | 31149650 | APL Bioeng | 2019 Jun | https://www.ncbi.nlm.nih.gov/pubmed/31149650 |
| Stretchable Hydrogel Electronics and Devices. | Lin S, Yuk H, Zhang T, Parada GA, Koo H, Yu C, Zhao X | Advanced materials (Deerfield Beach, Fla.) | 26639322 | Adv Mater | 2016 Jun | https://www.ncbi.nlm.nih.gov/pubmed/26639322 |
| Advancing cardiovascular tissue engineering. | Truskey GA | F1000Research | 27303643 | F1000Res | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/27303643 |
| Tough bonding of hydrogels to diverse non-porous surfaces. | Yuk H, Zhang T, Lin S, Parada GA, Zhao X | Nature materials | 26552058 | Nat Mater | 2016 Feb | https://www.ncbi.nlm.nih.gov/pubmed/26552058 |
| RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. | Thakore PI, Kwon JB, Nelson CE, Rouse DC, Gemberling MP, Oliver ML, Gersbach CA | Nature communications | 29700298 | Nat Commun | 2018 Apr 26 | https://www.ncbi.nlm.nih.gov/pubmed/29700298 |
| A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles. | Zhang X, Hong S, Yen R, Kondash M, Fernandez CE, Truskey GA | Lab on a chip | 30112530 | Lab Chip | 2018 Sep 11 | https://www.ncbi.nlm.nih.gov/pubmed/30112530 |
| Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality. | Cao C, Chan HF, Zang J, Leong KW, Zhao X | Advanced materials (Deerfield Beach, Fla.) | 24339233 | Adv Mater | 2014 Mar 19 | https://www.ncbi.nlm.nih.gov/pubmed/24339233 |
| Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies? | Chan HF, Ma S, Leong KW | Regenerative biomaterials | 27047674 | Regen Biomater | 2016 Jun | https://www.ncbi.nlm.nih.gov/pubmed/27047674 |
| Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. | Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, Hong S, Jung Y, Koves T, Kraus WE, Leong K, Madden L, Reichert WM, Zhao X | Stem cell research & therapy | 24565225 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565225 |
| Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. | Fernandez CE, Obi-onuoha IC, Wallace CS, Satterwhite LL, Truskey GA, Reichert WM | Acta biomaterialia | 24140604 | Acta Biomater | 2014 Feb | https://www.ncbi.nlm.nih.gov/pubmed/24140604 |
| Human Vascular Microphysiological System for in vitro Drug Screening. | Fernandez CE, Yen RW, Perez SM, Bedell HW, Povsic TJ, Reichert WM, Truskey GA | Scientific reports | 26888719 | Sci Rep | 2016 Feb 18 | https://www.ncbi.nlm.nih.gov/pubmed/26888719 |
| High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. | McGarrah RW, Craig DM, Haynes C, Dowdy ZE, Shah SH, Kraus WE | Atherosclerosis | 26803432 | Atherosclerosis | 2016 Mar | https://www.ncbi.nlm.nih.gov/pubmed/26803432 |
| Fringe instability in constrained soft elastic layers. | Lin S, Cohen T, Zhang T, Yuk H, Abeyaratne R, Zhao X | Soft matter | 27731462 | Soft Matter | 2016 Nov 4 | https://www.ncbi.nlm.nih.gov/pubmed/27731462 |
| Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. | Chen Z, Tang M, Huang D, Jiang W, Li M, Ji H, Park J, Xu B, Atchison LJ, Truskey GA, Leong KW | Lab on a chip | 29927449 | Lab Chip | 2018 Jul 10 | https://www.ncbi.nlm.nih.gov/pubmed/29927449 |
| Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. | Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N | eLife | 25575180 | Elife | 2015 Jan 9 | https://www.ncbi.nlm.nih.gov/pubmed/25575180 |
| Physiology and metabolism of tissue-engineered skeletal muscle. | Cheng CS, Davis BN, Madden L, Bursac N, Truskey GA | Experimental biology and medicine (Maywood, N.J.) | 24912506 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24912506 |
| On-demand hierarchical patterning with electric fields. | Wang Q, Robinson D, Zhao X | Applied physics letters | 25316923 | Appl Phys Lett | 2014 Jun 9 | https://www.ncbi.nlm.nih.gov/pubmed/25316923 |
| Skin-inspired hydrogel-elastomer hybrids with robust interfaces and functional microstructures. | Yuk H, Zhang T, Parada GA, Liu X, Zhao X | Nature communications | 27345380 | Nat Commun | 2016 Jun 27 | https://www.ncbi.nlm.nih.gov/pubmed/27345380 |
| Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors. | Thakore PI, Gersbach CA | Methods in molecular biology (Clifton, N.J.) | 26443215 | Methods Mol Biol | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/26443215 |
| Engineered skeletal muscles for disease modeling and drug discovery. | Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N | Biomaterials | 31419653 | Biomaterials | 2019 Nov | https://www.ncbi.nlm.nih.gov/pubmed/31419653 |
| iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome. | Atchison L, Abutaleb NO, Snyder-Mounts E, Gete Y, Ladha A, Ribar T, Cao K, Truskey GA | Stem cell reports | 32032552 | Stem Cell Reports | 2020 Feb 11 | https://www.ncbi.nlm.nih.gov/pubmed/32032552 |
| Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. | Khodabukus A, Kaza A, Wang J, Prabhu N, Goldstein R, Vaidya VS, Bursac N | Toxicological sciences : an official journal of the Society of Toxicology | 32294208 | Toxicol Sci | 2020 Jul 1 | https://www.ncbi.nlm.nih.gov/pubmed/32294208 |
| Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. | Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong KW | PloS one | 23785459 | PLoS One | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/23785459 |
| MicroRNA delivery for regenerative medicine. | Peng B, Chen Y, Leong KW | Advanced drug delivery reviews | 26024978 | Adv Drug Deliv Rev | 2015 Jul 1 | https://www.ncbi.nlm.nih.gov/pubmed/26024978 |
| 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. | Hong S, Sycks D, Chan HF, Lin S, Lopez GP, Guilak F, Leong KW, Zhao X | Advanced materials (Deerfield Beach, Fla.) | 26033288 | Adv Mater | 2015 Jul 15 | https://www.ncbi.nlm.nih.gov/pubmed/26033288 |
| Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. | Bursac N, Juhas M, Rando TA | Annual review of biomedical engineering | 26643021 | Annu Rev Biomed Eng | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26643021 |
| Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions. | Chan HF, Zhang Y, Leong KW | Small (Weinheim an der Bergstrasse, Germany) | 27038291 | Small | 2016 May | https://www.ncbi.nlm.nih.gov/pubmed/27038291 |
| Distilling complexity to advance cardiac tissue engineering. | Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G | Science translational medicine | 27280684 | Sci Transl Med | 2016 Jun 8 | https://www.ncbi.nlm.nih.gov/pubmed/27280684 |
| Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. | Jung Y, Ji H, Chen Z, Fai Chan H, Atchison L, Klitzman B, Truskey G, Leong KW | Scientific reports | 26456074 | Sci Rep | 2015 Oct 12 | https://www.ncbi.nlm.nih.gov/pubmed/26456074 |
| Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. | Chakraborty S, Ji H, Chen J, Gersbach CA, Leong KW | Scientific reports | 25492703 | Sci Rep | 2014 Dec 10 | https://www.ncbi.nlm.nih.gov/pubmed/25492703 |
| A versatile platform for surface modification of microfluidic droplets. | Li M, Jiang W, Chen Z, Suryaprakash S, Lv S, Tang Z, Chen X, Leong KW | Lab on a chip | 28154857 | Lab Chip | 2017 Feb 14 | https://www.ncbi.nlm.nih.gov/pubmed/28154857 |
| The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons. | Kulangara K, Adler AF, Wang H, Chellappan M, Hammett E, Yasuda R, Leong KW | Biomaterials | 24709523 | Biomaterials | 2014 Jul | https://www.ncbi.nlm.nih.gov/pubmed/24709523 |
| Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles. | Rangarajan S, Madden L, Bursac N | Annals of biomedical engineering | 24366526 | Ann Biomed Eng | 2014 Jul | https://www.ncbi.nlm.nih.gov/pubmed/24366526 |
| Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. | Cheng CS, El-Abd Y, Bui K, Hyun YE, Hughes RH, Kraus WE, Truskey GA | American journal of physiology. Cell physiology | 24336652 | Am J Physiol Cell Physiol | 2014 Feb 15 | https://www.ncbi.nlm.nih.gov/pubmed/24336652 |
| Multifunctionality and control of the crumpling and unfolding of large-area graphene. | Zang J, Ryu S, Pugno N, Wang Q, Tu Q, Buehler MJ, Zhao X | Nature materials | 23334002 | Nat Mater | 2013 Apr | https://www.ncbi.nlm.nih.gov/pubmed/23334002 |
| Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. | Zhang D, Shadrin IY, Lam J, Xian HQ, Snodgrass HR, Bursac N | Biomaterials | 23642535 | Biomaterials | 2013 Jul | https://www.ncbi.nlm.nih.gov/pubmed/23642535 |
| Modeling statin myopathy in a human skeletal muscle microphysiological system. | Ananthakumar A, Liu Y, Fernandez CE, Truskey GA, Voora D | PloS one | 33237943 | PLoS One | 2020 | https://www.ncbi.nlm.nih.gov/pubmed/33237943 |
| Dynamic culture yields engineered myocardium with near-adult functional output. | Jackman CP, Carlson AL, Bursac N | Biomaterials | 27723557 | Biomaterials | 2016 Dec | https://www.ncbi.nlm.nih.gov/pubmed/27723557 |
| NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection. | Juul S, Obliosca JM, Liu C, Liu YL, Chen YA, Imphean DM, Knudsen BR, Ho YP, Leong KW, Yeh HC | Nanoscale | 25901841 | Nanoscale | 2015 May 14 | https://www.ncbi.nlm.nih.gov/pubmed/25901841 |
| Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. | Cheng CS, Ran L, Bursac N, Kraus WE, Truskey GA | Tissue engineering. Part A | 26891613 | Tissue Eng Part A | 2016 Apr | https://www.ncbi.nlm.nih.gov/pubmed/26891613 |
| Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. | Kabadi AM, Thakore PI, Vockley CM, Ousterout DG, Gibson TM, Guilak F, Reddy TE, Gersbach CA | ACS synthetic biology | 25494287 | ACS Synth Biol | 2015 Jun 19 | https://www.ncbi.nlm.nih.gov/pubmed/25494287 |
| Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle. | Kondash ME, Ananthakumar A, Khodabukus A, Bursac N, Truskey GA | Tissue engineering and regenerative medicine | 32200516 | Tissue Eng Regen Med | 2020 Dec | https://www.ncbi.nlm.nih.gov/pubmed/32200516 |
| In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. | Khodabukus A, Prabhu N, Wang J, Bursac N | Advanced healthcare materials | 29696831 | Adv Healthc Mater | 2018 Aug | https://www.ncbi.nlm.nih.gov/pubmed/29696831 |
| The Development of TALE Nucleases for Biotechnology. | Ousterout DG, Gersbach CA | Methods in molecular biology (Clifton, N.J.) | 26443211 | Methods Mol Biol | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/26443211 |
| Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome. | Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA | Scientific reports | 36977745 | Sci Rep | 2023 Mar 28 | https://www.ncbi.nlm.nih.gov/pubmed/36977745 |
| Materials innovation for co-delivery of diverse therapeutic cargos. | Godsey ME, Suryaprakash S, Leong KW | RSC advances | 24818000 | RSC Adv | 2013 Dec 21 | https://www.ncbi.nlm.nih.gov/pubmed/24818000 |
| Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks. | Zhao X | Soft matter | 24834901 | Soft Matter | 2014 Feb 7 | https://www.ncbi.nlm.nih.gov/pubmed/24834901 |
| Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems. | Hong S, Jung Y, Yen R, Chan HF, Leong KW, Truskey GA, Zhao X | Lab on a chip | 24310854 | Lab Chip | 2014 Feb 7 | https://www.ncbi.nlm.nih.gov/pubmed/24310854 |
| Transdifferentiation of human endothelial progenitors into smooth muscle cells. | Ji H, Atchison L, Chen Z, Chakraborty S, Jung Y, Truskey GA, Christoforou N, Leong KW | Biomaterials | 26874281 | Biomaterials | 2016 Apr | https://www.ncbi.nlm.nih.gov/pubmed/26874281 |
| Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity. | Davis BN, Santoso JW, Walker MJ, Cheng CS, Koves TR, Kraus WE, Truskey GA | Tissue engineering. Part C, Methods | 28338413 | Tissue Eng Part C Methods | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/28338413 |
| Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair. | Jackman CP, Shadrin IY, Carlson AL, Bursac N | Current opinion in chemical engineering | 25599018 | Curr Opin Chem Eng | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25599018 |
| Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL | Scientific reports | 28176881 | Sci Rep | 2017 Feb 8 | https://www.ncbi.nlm.nih.gov/pubmed/28176881 |
| Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide. | Wang HX, Song Z, Lao YH, Xu X, Gong J, Cheng D, Chakraborty S, Park JS, Li M, Huang D, Yin L, Cheng J, Leong KW | Proceedings of the National Academy of Sciences of the United States of America | 29686087 | Proc Natl Acad Sci U S A | 2018 May 8 | https://www.ncbi.nlm.nih.gov/pubmed/29686087 |
| Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle. | Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, Bursac N | Biomaterials | 30180985 | Biomaterials | 2019 Apr | https://www.ncbi.nlm.nih.gov/pubmed/30180985 |
| Tissue-engineered blood vessels as promising tools for testing drug toxicity. | Truskey GA, Fernandez CE | Expert opinion on drug metabolism & toxicology | 26028128 | Expert Opin Drug Metab Toxicol | 2015 Jul | https://www.ncbi.nlm.nih.gov/pubmed/26028128 |
| Striated muscle function, regeneration, and repair. | Shadrin IY, Khodabukus A, Bursac N | Cellular and molecular life sciences : CMLS | 27271751 | Cell Mol Life Sci | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/27271751 |
| Engineering human pluripotent stem cells into a functional skeletal muscle tissue. | Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N | Nature communications | 29317646 | Nat Commun | 2018 Jan 9 | https://www.ncbi.nlm.nih.gov/pubmed/29317646 |
| Application of induced pluripotent stem cells to model smooth muscle cell function in vascular diseases. | Ji H, Kim HS, Kim HW, Leong KW | Current opinion in biomedical engineering | 29082353 | Curr Opin Biomed Eng | 2017 Mar | https://www.ncbi.nlm.nih.gov/pubmed/29082353 |
| Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. | Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS | The Journal of clinical investigation | 27869651 | J Clin Invest | 2017 Jan 3 | https://www.ncbi.nlm.nih.gov/pubmed/27869651 |
| Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. | Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS | Translational research : the journal of laboratory and clinical medicine | 27815136 | Transl Res | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/27815136 |
| Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. | Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD | Drug metabolism and disposition: the biological fate of chemicals | 27621205 | Drug Metab Dispos | 2016 Dec | https://www.ncbi.nlm.nih.gov/pubmed/27621205 |
| Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. | Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I | Scientific reports | 30291268 | Sci Rep | 2018 Oct 5 | https://www.ncbi.nlm.nih.gov/pubmed/30291268 |
| Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. | Kotha S, Sun S, Adams A, Hayes B, Phong KT, Nagao R, Reems JA, Gao D, Torok-Storb B, López JA, Zheng Y | PloS one | 29617409 | PLoS One | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29617409 |
| Reconstructing the Human Renal Vascular-Tubular Unit In Vitro. | Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y | Advanced healthcare materials | 30379416 | Adv Healthc Mater | 2018 Dec | https://www.ncbi.nlm.nih.gov/pubmed/30379416 |
| Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci. | Sieber KB, Batorsky A, Siebenthall K, Hudkins KL, Vierstra JD, Sullivan S, Sur A, McNulty M, Sandstrom R, Reynolds A, Bates D, Diegel M, Dunn D, Nelson J, Buckley M, Kaul R, Sampson MG, Himmelfarb J, Alpers CE, Waterworth D, Akilesh S | Journal of the American Society of Nephrology : JASN | 30760496 | J Am Soc Nephrol | 2019 Mar | https://www.ncbi.nlm.nih.gov/pubmed/30760496 |
| Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel. | Hiraki HL, Nagao RJ, Himmelfarb J, Zheng Y | Journal of visualized experiments : JoVE | 30371659 | J Vis Exp | 2018 Oct 13 | https://www.ncbi.nlm.nih.gov/pubmed/30371659 |
| EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. | Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield JS | Journal of the American Society of Nephrology : JASN | 23492730 | J Am Soc Nephrol | 2013 Mar | https://www.ncbi.nlm.nih.gov/pubmed/23492730 |
| Pericytes in kidney fibrosis. | Ren S, Duffield JS | Current opinion in nephrology and hypertension | 23722183 | Curr Opin Nephrol Hypertens | 2013 Jul | https://www.ncbi.nlm.nih.gov/pubmed/23722183 |
| Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. | Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS | Journal of immunology (Baltimore, Md. : 1950) | 23956422 | J Immunol | 2013 Sep 15 | https://www.ncbi.nlm.nih.gov/pubmed/23956422 |
| Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function. | Chang SY, Weber EJ, Ness KV, Eaton DL, Kelly EJ | Clinical pharmacology and therapeutics | 27448090 | Clin Pharmacol Ther | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/27448090 |
| Development of a microphysiological model of human kidney proximal tubule function. | Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ | Kidney international | 27521113 | Kidney Int | 2016 Sep | https://www.ncbi.nlm.nih.gov/pubmed/27521113 |
| Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS. | Kawakami T, Gomez IG, Ren S, Hudkins K, Roach A, Alpers CE, Shankland SJ, D'Agati VD, Duffield JS | Journal of the American Society of Nephrology : JASN | 25406339 | J Am Soc Nephrol | 2015 May | https://www.ncbi.nlm.nih.gov/pubmed/25406339 |
| High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. | Czerniecki SM, Cruz NM, Harder JL, Menon R, Annis J, Otto EA, Gulieva RE, Islas LV, Kim YK, Tran LM, Martins TJ, Pippin JW, Fu H, Kretzler M, Shankland SJ, Himmelfarb J, Moon RT, Paragas N, Freedman BS | Cell stem cell | 29779890 | Cell Stem Cell | 2018 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/29779890 |
| Tissue-engineered microenvironment systems for modeling human vasculature. | Tourovskaia A, Fauver M, Kramer G, Simonson S, Neumann T | Experimental biology and medicine (Maywood, N.J.) | 25030480 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/25030480 |
| Changes in macrophage phenotype as the immune response evolves. | Lichtnekert J, Kawakami T, Parks WC, Duffield JS | Current opinion in pharmacology | 23747023 | Curr Opin Pharmacol | 2013 Aug | https://www.ncbi.nlm.nih.gov/pubmed/23747023 |
| Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. | Watson DE, Hunziker R, Wikswo JP | Experimental biology and medicine (Maywood, N.J.) | 29065799 | Exp Biol Med (Maywood) | 2017 Oct | https://www.ncbi.nlm.nih.gov/pubmed/29065799 |
| Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. | Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ | Toxicology | 32905824 | Toxicology | 2020 Nov | https://www.ncbi.nlm.nih.gov/pubmed/32905824 |
| Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia. | Cruz NM, Reddy R, McFaline-Figueroa JL, Tran C, Fu H, Freedman BS | Nature biomedical engineering | 35478224 | Nat Biomed Eng | 2022 Apr | https://www.ncbi.nlm.nih.gov/pubmed/35478224 |
| Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease. | Juliar BA, Stanaway IB, Sano F, Fu H, Smith KD, Akilesh S, Scales SJ, El Saghir J, Bhatraju PK, Liu E, Yang J, Lin J, Eddy S, Kretzler M, Zheng Y, Himmelfarb J, Harder JL, Freedman BS | Cell reports | 38838223 | Cell Rep | 2024 Jun 25 | https://www.ncbi.nlm.nih.gov/pubmed/38838223 |
| Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. | Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M | Gastroenterology | 26677983 | Gastroenterology | 2016 Mar | https://www.ncbi.nlm.nih.gov/pubmed/26677983 |
| Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism. | Yamaura Y, Chapron BD, Wang Z, Himmelfarb J, Thummel KE | Drug metabolism and disposition: the biological fate of chemicals | 26700954 | Drug Metab Dispos | 2016 Mar | https://www.ncbi.nlm.nih.gov/pubmed/26700954 |
| Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. | Bhatraju PK, Cohen M, Nagao RJ, Morrell ED, Kosamo S, Chai XY, Nance R, Dmyterko V, Delaney J, Christie JD, Liu KD, Mikacenic C, Gharib SA, Liles WC, Zheng Y, Christiani DC, Himmelfarb J, Wurfel MM | BMC nephrology | 32680471 | BMC Nephrol | 2020 Jul 17 | https://www.ncbi.nlm.nih.gov/pubmed/32680471 |
| Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection. | Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M | Gut microbes | 32378997 | Gut Microbes | 2020 Nov 9 | https://www.ncbi.nlm.nih.gov/pubmed/32378997 |
| Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. | Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA | Toxicology in vitro : an international journal published in association with BIBRA | 31857146 | Toxicol In Vitro | 2020 Mar | https://www.ncbi.nlm.nih.gov/pubmed/31857146 |
| Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. | Campanholle G, Ligresti G, Gharib SA, Duffield JS | American journal of physiology. Cell physiology | 23325411 | Am J Physiol Cell Physiol | 2013 Apr 1 | https://www.ncbi.nlm.nih.gov/pubmed/23325411 |
| A Novel Three-Dimensional Human Peritubular Microvascular System. | Ligresti G, Nagao RJ, Xue J, Choi YJ, Xu J, Ren S, Aburatani T, Anderson SK, MacDonald JW, Bammler TK, Schwartz SM, Muczynski KA, Duffield JS, Himmelfarb J, Zheng Y | Journal of the American Society of Nephrology : JASN | 26657868 | J Am Soc Nephrol | 2016 Aug | https://www.ncbi.nlm.nih.gov/pubmed/26657868 |
| Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease. | Nakagawa N, Barron L, Gomez IG, Johnson BG, Roach AM, Kameoka S, Jack RM, Lupher ML Jr, Gharib SA, Duffield JS | JCI insight | 27942582 | JCI Insight | 2016 Dec 8 | https://www.ncbi.nlm.nih.gov/pubmed/27942582 |
| Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component? | Cyr KJ, Avaldi OM, Wikswo JP | Experimental biology and medicine (Maywood, N.J.) | 29065796 | Exp Biol Med (Maywood) | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/29065796 |
| Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. | Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ | JCI insight | 30568031 | JCI Insight | 2018 Dec 20 | https://www.ncbi.nlm.nih.gov/pubmed/30568031 |
| Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. | Maass C, Sorensen NB, Himmelfarb J, Kelly EJ, Stokes CL, Cirit M | CPT: pharmacometrics & systems pharmacology | 30869201 | CPT Pharmacometrics Syst Pharmacol | 2019 May | https://www.ncbi.nlm.nih.gov/pubmed/30869201 |
| A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. | Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS | Journal of the American Society of Nephrology : JASN | 26260164 | J Am Soc Nephrol | 2016 Apr | https://www.ncbi.nlm.nih.gov/pubmed/26260164 |
| Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease. | Li SR, Gulieva RE, Helms L, Cruz NM, Vincent T, Fu H, Himmelfarb J, Freedman BS | Nature communications | 36564419 | Nat Commun | 2022 Dec 23 | https://www.ncbi.nlm.nih.gov/pubmed/36564419 |
| Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system. | Lidberg KA, Jones-Isaac K, Yang J, Bain J, Wang L, MacDonald JW, Bammler TK, Calamia J, Thummel KE, Yeung CK, Countryman S, Koenig P, Himmelfarb J, Kelly EJ | NPJ microgravity | 38982119 | NPJ Microgravity | 2024 Jul 9 | https://www.ncbi.nlm.nih.gov/pubmed/38982119 |
| Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury. | Chen YT, Chang YT, Pan SY, Chou YH, Chang FC, Yeh PY, Liu YH, Chiang WC, Chen YM, Wu KD, Tsai TJ, Duffield JS, Lin SL | Journal of the American Society of Nephrology : JASN | 24854266 | J Am Soc Nephrol | 2014 Dec | https://www.ncbi.nlm.nih.gov/pubmed/24854266 |
| Cellular and molecular mechanisms in kidney fibrosis. | Duffield JS | The Journal of clinical investigation | 24892703 | J Clin Invest | 2014 Jun | https://www.ncbi.nlm.nih.gov/pubmed/24892703 |
| The inexorable rise of AKI: can we bend the growth curve? | Siew ED, Himmelfarb J | Journal of the American Society of Nephrology : JASN | 23243210 | J Am Soc Nephrol | 2013 Jan | https://www.ncbi.nlm.nih.gov/pubmed/23243210 |
| Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. | Yeung CK, Shen DD, Thummel KE, Himmelfarb J | Kidney international | 24132209 | Kidney Int | 2014 Mar | https://www.ncbi.nlm.nih.gov/pubmed/24132209 |
| Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. | Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ | Scientific reports | 33633318 | Sci Rep | 2021 Feb 25 | https://www.ncbi.nlm.nih.gov/pubmed/33633318 |
| Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. | Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 27871064 | FASEB J | 2017 Feb | https://www.ncbi.nlm.nih.gov/pubmed/27871064 |
| Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. | Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL | JCI insight | 29202460 | JCI Insight | 2017 Nov 16 | https://www.ncbi.nlm.nih.gov/pubmed/29202460 |
| Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. | Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL | Toxicology in vitro : an international journal published in association with BIBRA | 28089783 | Toxicol In Vitro | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/28089783 |
| TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease. | Gomez IG, Roach AM, Nakagawa N, Amatucci A, Johnson BG, Dunn K, Kelly MC, Karaca G, Zheng TS, Szak S, Peppiatt-Wildman CM, Burkly LC, Duffield JS | Journal of the American Society of Nephrology : JASN | 27026366 | J Am Soc Nephrol | 2016 Dec | https://www.ncbi.nlm.nih.gov/pubmed/27026366 |
| A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. | Miller CP, Tsuchida C, Zheng Y, Himmelfarb J, Akilesh S | Neoplasia (New York, N.Y.) | 29747161 | Neoplasia | 2018 Jun | https://www.ncbi.nlm.nih.gov/pubmed/29747161 |
| Microphysiological Systems to Assess Nonclinical Toxicity. | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ | Current protocols in toxicology | 28777442 | Curr Protoc Toxicol | 2017 Aug 4 | https://www.ncbi.nlm.nih.gov/pubmed/28777442 |
| Human Organ-Specific Endothelial Cell Heterogeneity. | Marcu R, Choi YJ, Xue J, Fortin CL, Wang Y, Nagao RJ, Xu J, MacDonald JW, Bammler TK, Murry CE, Muczynski K, Stevens KR, Himmelfarb J, Schwartz SM, Zheng Y | iScience | 30240741 | iScience | 2018 Jun 29 | https://www.ncbi.nlm.nih.gov/pubmed/30240741 |
| Kidney microphysiological models for nephrotoxicity assessment. | Mahadeo A, Yeung CK, Himmelfarb J, Kelly EJ | Current opinion in toxicology | 35495549 | Curr Opin Toxicol | 2022 Jun | https://www.ncbi.nlm.nih.gov/pubmed/35495549 |
| Cyclosporine Induces Fenestra-Associated Injury in Human Renal Microvessels In Vitro. | Nagao RJ, Marcu R, Shin YJ, Lih D, Xue J, Arang N, Wei L, Akilesh S, Kaushansky A, Himmelfarb J, Zheng Y | ACS biomaterials science & engineering | 34927415 | ACS Biomater Sci Eng | 2022 Jan 10 | https://www.ncbi.nlm.nih.gov/pubmed/34927415 |
| Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. | Hung C, Linn G, Chow YH, Kobayashi A, Mittelsteadt K, Altemeier WA, Gharib SA, Schnapp LM, Duffield JS | American journal of respiratory and critical care medicine | 23924232 | Am J Respir Crit Care Med | 2013 Oct 1 | https://www.ncbi.nlm.nih.gov/pubmed/23924232 |
| Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. | Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, Himmelfarb J | Stem cell research & therapy | 24564863 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24564863 |
| RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis. | Craciun FL, Bijol V, Ajay AK, Rao P, Kumar RK, Hutchinson J, Hofmann O, Joshi N, Luyendyk JP, Kusebauch U, Moss CL, Srivastava A, Himmelfarb J, Waikar SS, Moritz RL, Vaidya VS | Journal of the American Society of Nephrology : JASN | 26449608 | J Am Soc Nephrol | 2016 Jun | https://www.ncbi.nlm.nih.gov/pubmed/26449608 |
| Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. | Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G | Drug metabolism and disposition: the biological fate of chemicals | 30076203 | Drug Metab Dispos | 2018 Nov | https://www.ncbi.nlm.nih.gov/pubmed/30076203 |
| Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble-Mediated Drug Delivery. | Juang EK, De Cock I, Keravnou C, Gallagher MK, Keller SB, Zheng Y, Averkiou M | Langmuir : the ACS journal of surfaces and colloids | 30540481 | Langmuir | 2019 Aug 6 | https://www.ncbi.nlm.nih.gov/pubmed/30540481 |
| Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease. | Cruz NM, Song X, Czerniecki SM, Gulieva RE, Churchill AJ, Kim YK, Winston K, Tran LM, Diaz MA, Fu H, Finn LS, Pei Y, Himmelfarb J, Freedman BS | Nature materials | 28967916 | Nat Mater | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/28967916 |
| Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. | Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS | The Journal of clinical investigation | 25415439 | J Clin Invest | 2015 Jan | https://www.ncbi.nlm.nih.gov/pubmed/25415439 |
| A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. | Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS | Journal of the American Society of Nephrology : JASN | 30361326 | J Am Soc Nephrol | 2018 Dec | https://www.ncbi.nlm.nih.gov/pubmed/30361326 |
| A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro. | Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS | Toxicological sciences : an official journal of the Society of Toxicology | 30649541 | Toxicol Sci | 2019 May 1 | https://www.ncbi.nlm.nih.gov/pubmed/30649541 |
| The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury. | Gomez IG, Duffield JS | Kidney international supplements | 26312147 | Kidney Int Suppl (2011) | 2014 Nov | https://www.ncbi.nlm.nih.gov/pubmed/26312147 |
| Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence. | Nagao RJ, Xu J, Luo P, Xue J, Wang Y, Kotha S, Zeng W, Fu X, Himmelfarb J, Zheng Y | Tissue engineering. Part A | 27481445 | Tissue Eng Part A | 2016 Oct | https://www.ncbi.nlm.nih.gov/pubmed/27481445 |
| Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. | Weber EJ, Himmelfarb J, Kelly EJ | Current opinion in toxicology | 29057384 | Curr Opin Toxicol | 2017 Jun | https://www.ncbi.nlm.nih.gov/pubmed/29057384 |
| Development of a kidney microphysiological system hardware platform for microgravity studies. | Jones-Isaac KA, Lidberg KA, Yeung CK, Yang J, Bain J, Ruiz M, Koenig G, Koenig P, Countryman S, Himmelfarb J, Kelly EJ | NPJ microgravity | 38734683 | NPJ Microgravity | 2024 May 11 | https://www.ncbi.nlm.nih.gov/pubmed/38734683 |
| Impact of microgravity on a three-dimensional microphysiologic culture of the human kidney proximal tubule epithelium: cell response to serum and vitamin D. | Kelly E, Lindberg K, Jones-Isaac K, Yang J, Bain J, Wang L, MacDonald J, Bammler T, Calamia J, Thummel K, Yeung C, Countryman S, Koenig P, Himmelfarb J | Research square | 38196580 | Res Sq | 2023 Dec 21 | https://www.ncbi.nlm.nih.gov/pubmed/38196580 |
| Development of a Kidney Microphysiological System Hardware Platform for Microgravity Studies. | Yeung C, Jones-Isaac K, Lindberg K, Yang J, Bain J, Ruiz M, Koenig G, Koenig P, Countryman S, Himmelfarb J, Kelly E | Research square | 38196654 | Res Sq | 2023 Dec 22 | https://www.ncbi.nlm.nih.gov/pubmed/38196654 |
| Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies. | Usta OB, McCarty WJ, Bale S, Hegde M, Jindal R, Bhushan A, Golberg I, Yarmush ML | Technology | 26167518 | Technology (Singap World Sci) | 2015 Mar | https://www.ncbi.nlm.nih.gov/pubmed/26167518 |
| A human liver microphysiology platform for investigating physiology, drug safety, and disease models. | Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL | Experimental biology and medicine (Maywood, N.J.) | 26202373 | Exp Biol Med (Maywood) | 2016 Jan | https://www.ncbi.nlm.nih.gov/pubmed/26202373 |
| Development of a low-volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization. | Ghodbane M, Kulesa A, Yu HH, Maguire TJ, Schloss RR, Ramachandran R, Zahn JD, Yarmush ML | Microfluidics and nanofluidics | 25691853 | Microfluid Nanofluidics | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25691853 |
| Biotunable acoustic node assembly of organoids. | Chen P, Güven S, Usta OB, Yarmush ML, Demirci U | Advanced healthcare materials | 26149464 | Adv Healthc Mater | 2015 Sep 16 | https://www.ncbi.nlm.nih.gov/pubmed/26149464 |
| Biologically Relevant Heterogeneity: Metrics and Practical Insights. | Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL | SLAS discovery : advancing life sciences R & D | 28231035 | SLAS Discov | 2017 Mar | https://www.ncbi.nlm.nih.gov/pubmed/28231035 |
| A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. | Stern AM, Schurdak ME, Bahar I, Berg JM, Taylor DL | Journal of biomolecular screening | 26962875 | J Biomol Screen | 2016 Jul | https://www.ncbi.nlm.nih.gov/pubmed/26962875 |
| A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture. | McCarty WJ, Usta OB, Luitje M, Bale SS, Bhushan A, Hegde M, Golberg I, Jindal R, Yarmush ML | Technology | 24932459 | Technology (Singap World Sci) | 2014 Mar | https://www.ncbi.nlm.nih.gov/pubmed/24932459 |
| Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells. | Bale SS, Golberg I, Jindal R, McCarty WJ, Luitje M, Hegde M, Bhushan A, Usta OB, Yarmush ML | Tissue engineering. Part C, Methods | 25233394 | Tissue Eng Part C Methods | 2015 Apr | https://www.ncbi.nlm.nih.gov/pubmed/25233394 |
| Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response. | Bale SS, Geerts S, Jindal R, Yarmush ML | Scientific reports | 27142224 | Sci Rep | 2016 May 4 | https://www.ncbi.nlm.nih.gov/pubmed/27142224 |
| Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). | Sakolish C, Reese CE, Luo YS, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Chiu WA, Vernetti LA, Rusyn I | Toxicology | 33307106 | Toxicology | 2021 Jan 30 | https://www.ncbi.nlm.nih.gov/pubmed/33307106 |
| A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®. | Bircsak KM, DeBiasio R, Miedel M, Alsebahi A, Reddinger R, Saleh A, Shun T, Vernetti LA, Gough A | Toxicology | 33359578 | Toxicology | 2021 Feb 28 | https://www.ncbi.nlm.nih.gov/pubmed/33359578 |
| Human Hepatocellular response in Cholestatic Liver Diseases. | Ortiz K, Cetin Z, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Ostrowska A, Soto-Gutierrez A, Faccioli LAP | Organogenesis | 37598346 | Organogenesis | 2023 Dec 31 | https://www.ncbi.nlm.nih.gov/pubmed/37598346 |
| Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. | Bhushan A, Senutovitch N, Bale SS, McCarty WJ, Hegde M, Jindal R, Golberg I, Berk Usta O, Yarmush ML, Vernetti L, Gough A, Bakan A, Shun TY, DeBiasio R, Lansing Taylor D | Stem cell research & therapy | 24565476 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565476 |
| Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform. | Hegde M, Jindal R, Bhushan A, Bale SS, McCarty WJ, Golberg I, Usta OB, Yarmush ML | Lab on a chip | 24770663 | Lab Chip | 2014 Jun 21 | https://www.ncbi.nlm.nih.gov/pubmed/24770663 |
| In vitro platforms for evaluating liver toxicity. | Bale SS, Vernetti L, Senutovitch N, Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta BO, Taylor DL, Yarmush ML | Experimental biology and medicine (Maywood, N.J.) | 24764241 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24764241 |
| The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models. | Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL | Applied in vitro toxicology | 28781990 | Appl In Vitro Toxicol | 2016 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/28781990 |
| SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. | Tobita T, Guzman-Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, Deng CX, Collin de l'Hortet A, Soto-Gutierrez A | PloS one | 26890260 | PLoS One | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/26890260 |
| A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation. | McCarty WJ, Usta OB, Yarmush ML | Scientific reports | 27240736 | Sci Rep | 2016 May 31 | https://www.ncbi.nlm.nih.gov/pubmed/27240736 |
| Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization. | McCarty WJ, Prodanov L, Bale SS, Bhushan A, Jindal R, Yarmush ML, Usta OB | Journal of visualized experiments : JoVE | 26485274 | J Vis Exp | 2015 Sep 29 | https://www.ncbi.nlm.nih.gov/pubmed/26485274 |
| Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants. | Faccioli LAP, Cetin Z, Kocas-Kilicarslan ZN, Ortiz K, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Wang Z, Xia M, Miedel MT, Taylor DL, Behari J, Ostrowska A, Constantine R, Li A, Soto-Gutierrez A | International journal of molecular sciences | 37686209 | Int J Mol Sci | 2023 Aug 29 | https://www.ncbi.nlm.nih.gov/pubmed/37686209 |
| Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. | In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M | Nature reviews. Gastroenterology & hepatology | 27677718 | Nat Rev Gastroenterol Hepatol | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/27677718 |
| A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity. | Bale SS, Sridharan GV, Golberg I, Prodanov L, McCarty WJ, Usta OB, Jindal R, Yarmush ML | Technology | 26925437 | Technology (Singap World Sci) | 2015 Dec | https://www.ncbi.nlm.nih.gov/pubmed/26925437 |
| Fluorescent protein biosensors applied to microphysiological systems. | Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL | Experimental biology and medicine (Maywood, N.J.) | 25990438 | Exp Biol Med (Maywood) | 2015 Jun | https://www.ncbi.nlm.nih.gov/pubmed/25990438 |
| Human organoid cultures: transformative new tools for human virus studies. | Ramani S, Crawford SE, Blutt SE, Estes MK | Current opinion in virology | 29656244 | Curr Opin Virol | 2018 Apr | https://www.ncbi.nlm.nih.gov/pubmed/29656244 |
| Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. | Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL | PloS one | 25036749 | PLoS One | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25036749 |
| Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. | Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL | Experimental biology and medicine (Maywood, N.J.) | 28409533 | Exp Biol Med (Maywood) | 2017 Oct | https://www.ncbi.nlm.nih.gov/pubmed/28409533 |
| Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy. | Vernetti LA, Vogt A, Gough A, Taylor DL | Clinics in liver disease | 27842772 | Clin Liver Dis | 2017 Feb | https://www.ncbi.nlm.nih.gov/pubmed/27842772 |
| A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. | Li X, George SM, Vernetti L, Gough AH, Taylor DL | Lab on a chip | 30063238 | Lab Chip | 2018 Aug 21 | https://www.ncbi.nlm.nih.gov/pubmed/30063238 |
| Liver-Regenerative Transplantation: Regrow and Reset. | Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Handa K, Matsubara K, Fukumitsu K, Dorko K, Presnell SC, Yagi H, Soto-Gutierrez A | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 26699680 | Am J Transplant | 2016 Jun | https://www.ncbi.nlm.nih.gov/pubmed/26699680 |
| iPSC-Derived Neurons from Patients with POLG Mutations Exhibit Decreased Mitochondrial Content and Dendrite Simplification. | Verma M, Francis L, Lizama BN, Callio J, Fricklas G, Wang KZQ, Kaufman BA, D'Aiuto L, Stolz DB, Watkins SC, Nimgaonkar VL, Soto-Gutierrez A, Goldstein A, Chu CT | The American journal of pathology | 36414085 | Am J Pathol | 2023 Feb | https://www.ncbi.nlm.nih.gov/pubmed/36414085 |
| Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. | Sakolish C, Luo YS, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA | Toxicology | 34543702 | Toxicology | 2021 Nov | https://www.ncbi.nlm.nih.gov/pubmed/34543702 |
| Applications of the microphysiology systems database for experimental ADME-Tox and disease models. | Schurdak M, Vernetti L, Bergenthal L, Wolter QK, Shun TY, Karcher S, Taylor DL, Gough A | Lab on a chip | 32211684 | Lab Chip | 2020 Apr 14 | https://www.ncbi.nlm.nih.gov/pubmed/32211684 |
| Development and validation of a microfluidic immunoassay capable of multiplexing parallel samples in microliter volumes. | Ghodbane M, Stucky EC, Maguire TJ, Schloss RS, Shreiber DI, Zahn JD, Yarmush ML | Lab on a chip | 26130452 | Lab Chip | 2015 Aug 7 | https://www.ncbi.nlm.nih.gov/pubmed/26130452 |
| Long-term maintenance of a microfluidic 3D human liver sinusoid. | Prodanov L, Jindal R, Bale SS, Hegde M, McCarty WJ, Golberg I, Bhushan A, Yarmush ML, Usta OB | Biotechnology and bioengineering | 26152452 | Biotechnol Bioeng | 2016 Jan | https://www.ncbi.nlm.nih.gov/pubmed/26152452 |
| Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems. | Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP | Experimental biology and medicine (Maywood, N.J.) | 28467181 | Exp Biol Med (Maywood) | 2017 Oct | https://www.ncbi.nlm.nih.gov/pubmed/28467181 |
| Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes. | Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM | Oncology | 29306943 | Oncology | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29306943 |
| Liver metastases: Microenvironments and ex-vivo models. | Clark AM, Ma B, Taylor DL, Griffith L, Wells A | Experimental biology and medicine (Maywood, N.J.) | 27390264 | Exp Biol Med (Maywood) | 2016 Sep | https://www.ncbi.nlm.nih.gov/pubmed/27390264 |
| Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. | Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MK | American journal of physiology. Gastrointestinal and liver physiology | 34288725 | Am J Physiol Gastrointest Liver Physiol | 2021 Sep 1 | https://www.ncbi.nlm.nih.gov/pubmed/34288725 |
| Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. | Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, Fondevila C, Stärkel P, Dubuquoy L, Louvet A, Odena G, Gomez JL, Aragon T, Altamirano J, Caballeria J, Jurczak MJ, Taylor DL, Berasain C, Wahlestedt C, Monga SP, Morgan MY, Sancho-Bru P, Mathurin P, Furuya S, Lackner C, Rusyn I, Shah VH, Thursz MR, Mann J, Avila MA, Bataller R | Nature communications | 31311938 | Nat Commun | 2019 Jul 16 | https://www.ncbi.nlm.nih.gov/pubmed/31311938 |
| Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems. | Stokes CL, Cirit M, Lauffenburger DA | CPT: pharmacometrics & systems pharmacology | 26535154 | CPT Pharmacometrics Syst Pharmacol | 2015 Oct | https://www.ncbi.nlm.nih.gov/pubmed/26535154 |
| Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. | Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M | CPT: pharmacometrics & systems pharmacology | 26535159 | CPT Pharmacometrics Syst Pharmacol | 2015 Oct | https://www.ncbi.nlm.nih.gov/pubmed/26535159 |
| Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. | Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT | Drug discovery today | 24793141 | Drug Discov Today | 2014 Jun | https://www.ncbi.nlm.nih.gov/pubmed/24793141 |
| Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. | Taylor DP, Clark A, Wheeler S, Wells A | Breast cancer research and treatment | 24610032 | Breast Cancer Res Treat | 2014 Apr | https://www.ncbi.nlm.nih.gov/pubmed/24610032 |
| Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. | Beckwitt CH, Shiraha K, Wells A | PloS one | 29763460 | PLoS One | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29763460 |
| Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. | Grahovac J, Wells A | Laboratory investigation; a journal of technical methods and pathology | 24247562 | Lab Invest | 2014 Jan | https://www.ncbi.nlm.nih.gov/pubmed/24247562 |
| The dormancy dilemma: quiescence versus balanced proliferation. | Wells A, Griffith L, Wells JZ, Taylor DP | Cancer research | 23794703 | Cancer Res | 2013 Jul 1 | https://www.ncbi.nlm.nih.gov/pubmed/23794703 |
| Biomarker identification for statin sensitivity of cancer cell lines. | Raghu VK, Beckwitt CH, Warita K, Wells A, Benos PV, Oltvai ZN | Biochemical and biophysical research communications | 29146185 | Biochem Biophys Res Commun | 2018 Jan 1 | https://www.ncbi.nlm.nih.gov/pubmed/29146185 |
| Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. | Khazali AS, Clark AM, Wells A | British journal of cancer | 29169181 | Br J Cancer | 2018 Feb 20 | https://www.ncbi.nlm.nih.gov/pubmed/29169181 |
| A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. | Clark AM, Kumar MP, Wheeler SE, Young CL, Venkataramanan R, Stolz DB, Griffith LG, Lauffenburger DA, Wells A | Molecular & cellular proteomics : MCP | 29353230 | Mol Cell Proteomics | 2018 Apr | https://www.ncbi.nlm.nih.gov/pubmed/29353230 |
| MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. | Kader M, Alaoui-El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N | PLoS pathogens | 29049365 | PLoS Pathog | 2017 Oct | https://www.ncbi.nlm.nih.gov/pubmed/29049365 |
| All-human microphysical model of metastasis therapy. | Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, Wells A, Young C | Stem cell research & therapy | 24565274 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565274 |
| Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model. | Rivera-Burgos D, Sarkar U, Lever AR, Avram MJ, Coppeta JR, Wishnok JS, Borenstein JT, Tannenbaum SR | Drug metabolism and disposition: the biological fate of chemicals | 26586376 | Drug Metab Dispos | 2016 Feb | https://www.ncbi.nlm.nih.gov/pubmed/26586376 |
| A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. | Khazali AS, Clark AM, Wells A | Stem cell reviews and reports | 28425064 | Stem Cell Rev Rep | 2017 Jun | https://www.ncbi.nlm.nih.gov/pubmed/28425064 |
| Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. | Dioufa N, Clark AM, Ma B, Beckwitt CH, Wells A | Molecular cancer | 29137633 | Mol Cancer | 2017 Nov 14 | https://www.ncbi.nlm.nih.gov/pubmed/29137633 |
| Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells. | Furukawa M, Wheeler S, Clark AM, Wells A | PloS one | 25635394 | PLoS One | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/25635394 |
| CXCR3 in carcinoma progression. | Ma B, Khazali A, Wells A | Histology and histopathology | 25663474 | Histol Histopathol | 2015 Jul | https://www.ncbi.nlm.nih.gov/pubmed/25663474 |
| Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. | Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR | Drug metabolism and disposition: the biological fate of chemicals | 25926431 | Drug Metab Dispos | 2015 Jul | https://www.ncbi.nlm.nih.gov/pubmed/25926431 |
| Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. | Wheeler SE, Clark AM, Taylor DP, Young CL, Pillai VC, Stolz DB, Venkataramanan R, Lauffenburger D, Griffith L, Wells A | British journal of cancer | 25314052 | Br J Cancer | 2014 Dec 9 | https://www.ncbi.nlm.nih.gov/pubmed/25314052 |
| Adult Stem Cell Functioning in the Tumor Micro-Environment. | Jiang Y, Wells A, Sylakowski K, Clark AM, Ma B | International journal of molecular sciences | 31130595 | Int J Mol Sci | 2019 May 25 | https://www.ncbi.nlm.nih.gov/pubmed/31130595 |
| Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. | Ma B, Khazali A, Shao H, Jiang Y, Wells A | Cell communication and signaling : CCS | 31831069 | Cell Commun Signal | 2019 Dec 12 | https://www.ncbi.nlm.nih.gov/pubmed/31831069 |
| IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. | Clark AM, Heusey HL, Griffith LG, Lauffenburger DA, Wells A | Frontiers in oncology | 34123844 | Front Oncol | 2021 | https://www.ncbi.nlm.nih.gov/pubmed/34123844 |
| Use of ChemoFx® for Identification of Effective Treatments in Epithelial Ovarian Cancer. | Richard S, Wells A, Connor J, Price F | PLoS currents | 26213638 | PLoS Curr | 2015 Jul 13 | https://www.ncbi.nlm.nih.gov/pubmed/26213638 |
| Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. | Yang M, Ma B, Shao H, Clark AM, Wells A | BMC cancer | 27387344 | BMC Cancer | 2016 Jul 7 | https://www.ncbi.nlm.nih.gov/pubmed/27387344 |
| Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation. | Cambria E, Renggli K, Ahrens CC, Cook CD, Kroll C, Krueger AT, Imperiali B, Griffith LG | Biomacromolecules | 26098148 | Biomacromolecules | 2015 Aug 10 | https://www.ncbi.nlm.nih.gov/pubmed/26098148 |
| Tenascin-C Signaling in melanoma. | Shao H, Kirkwood JM, Wells A | Cell adhesion & migration | 25482624 | Cell Adh Migr | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/25482624 |
| Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System. | Tsamandouras N, Kostrzewski T, Stokes CL, Griffith LG, Hughes DJ, Cirit M | The Journal of pharmacology and experimental therapeutics | 27760784 | J Pharmacol Exp Ther | 2017 Jan | https://www.ncbi.nlm.nih.gov/pubmed/27760784 |
| Bioreactor technologies to support liver function in vitro. | Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG | Advanced drug delivery reviews | 24607703 | Adv Drug Deliv Rev | 2014 Apr | https://www.ncbi.nlm.nih.gov/pubmed/24607703 |
| A microphysiological system model of therapy for liver micrometastases. | Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A | Experimental biology and medicine (Maywood, N.J.) | 24821820 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24821820 |
| Modeling boundary conditions for balanced proliferation in metastatic latency. | Taylor DP, Wells JZ, Savol A, Chennubhotla C, Wells A | Clinical cancer research : an official journal of the American Association for Cancer Research | 23329811 | Clin Cancer Res | 2013 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/23329811 |
| Integrative microphysiological tissue systems of cancer metastasis to the liver. | Clark AM, Allbritton NL, Wells A | Seminars in cancer biology | 32580025 | Semin Cancer Biol | 2021 Jun | https://www.ncbi.nlm.nih.gov/pubmed/32580025 |
| A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. | Clark AM, Wheeler SE, Young CL, Stockdale L, Shepard Neiman J, Zhao W, Stolz DB, Venkataramanan R, Lauffenburger D, Griffith L, Wells A | Lab on a chip | 27910972 | Lab Chip | 2016 Dec 20 | https://www.ncbi.nlm.nih.gov/pubmed/27910972 |
| Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. | Ma B, Wheeler SE, Clark AM, Whaley DL, Yang M, Wells A | Hepatology (Baltimore, Md.) | 27482645 | Hepatology | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/27482645 |
| Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. | Warita K, Warita T, Beckwitt CH, Schurdak ME, Vazquez A, Wells A, Oltvai ZN | Scientific reports | 25534349 | Sci Rep | 2014 Dec 23 | https://www.ncbi.nlm.nih.gov/pubmed/25534349 |
| On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. | Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger D, White F, Griffith L | Biomaterials | 28371736 | Biomaterials | 2017 Jun | https://www.ncbi.nlm.nih.gov/pubmed/28371736 |
| The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. | Ma B, Wells A, Clark AM | Seminars in cancer biology | 31376430 | Semin Cancer Biol | 2020 Feb | https://www.ncbi.nlm.nih.gov/pubmed/31376430 |
| Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes. | Wang AJ, Allen A, Sofman M, Sphabmixay P, Yildiz E, Griffith LG | Advanced nanobiomed research | 35872804 | Adv Nanobiomed Res | 2022 Jan | https://www.ncbi.nlm.nih.gov/pubmed/35872804 |
| Engineering liver. | Griffith LG, Wells A, Stolz DB | Hepatology (Baltimore, Md.) | 24668880 | Hepatology | 2014 Oct | https://www.ncbi.nlm.nih.gov/pubmed/24668880 |
| The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells. | Ma B, Wells A | The Journal of biological chemistry | 24619413 | J Biol Chem | 2014 Apr 18 | https://www.ncbi.nlm.nih.gov/pubmed/24619413 |
| Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS). | Maass C, Stokes CL, Griffith LG, Cirit M | Integrative biology : quantitative biosciences from nano to macro | 28267162 | Integr Biol (Camb) | 2017 Apr 18 | https://www.ncbi.nlm.nih.gov/pubmed/28267162 |
| Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform. | Long TJ, Cosgrove PA, Dunn RT 2nd, Stolz DB, Hamadeh H, Afshari C, McBride H, Griffith LG | Drug metabolism and disposition: the biological fate of chemicals | 27621203 | Drug Metab Dispos | 2016 Dec | https://www.ncbi.nlm.nih.gov/pubmed/27621203 |
| Liver 'organ on a chip'. | Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A | Experimental cell research | 29291400 | Exp Cell Res | 2018 Feb 1 | https://www.ncbi.nlm.nih.gov/pubmed/29291400 |
| Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies. | Tsamandouras N, Chen WLK, Edington CD, Stokes CL, Griffith LG, Cirit M | The AAPS journal | 28752430 | AAPS J | 2017 Sep | https://www.ncbi.nlm.nih.gov/pubmed/28752430 |
| High resolution stereolithography fabrication of perfusable scaffolds to enable long-term meso-scale hepatic culture for disease modeling. | Sphabmixay P, Raredon MSB, Wang AJ, Lee H, Hammond PT, Fang NX, Griffith LG | Biofabrication | 34479229 | Biofabrication | 2021 Sep 21 | https://www.ncbi.nlm.nih.gov/pubmed/34479229 |
| Photopatterning of hydrogel scaffolds coupled to filter materials using stereolithography for perfused 3D culture of hepatocytes. | Neiman JA, Raman R, Chan V, Rhoads MG, Raredon MS, Velazquez JJ, Dyer RL, Bashir R, Hammond PT, Griffith LG | Biotechnology and bioengineering | 25384798 | Biotechnol Bioeng | 2015 Apr | https://www.ncbi.nlm.nih.gov/pubmed/25384798 |
| Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies. | Maass C, Dallas M, LaBarge ME, Shockley M, Valdez J, Geishecker E, Stokes CL, Griffith LG, Cirit M | Scientific reports | 29789564 | Sci Rep | 2018 May 22 | https://www.ncbi.nlm.nih.gov/pubmed/29789564 |
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| MALDI-TOF/TOF CID Study of Poly(1,4-dihydroxybenzene terephthalate) Fragmentation Reactions. | Gies AP, Stow SM, McLean JA, Hercules DM | Polymer | 26195848 | Polymer (Guildf) | 2015 May 1 | https://www.ncbi.nlm.nih.gov/pubmed/26195848 |
| Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status. | Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB | Metallomics : integrated biometal science | 25599126 | Metallomics | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25599126 |
| S100B and S100B autoantibody as biomarkers for early detection of brain metastases in lung cancer. | Choi H, Puvenna V, Brennan C, Mahmoud S, Wang XF, Phillips M, Janigro D, Mazzone P | Translational lung cancer research | 27652205 | Transl Lung Cancer Res | 2016 Aug | https://www.ncbi.nlm.nih.gov/pubmed/27652205 |
| Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells. | Ghosh C, Hossain M, Solanki J, Najm IM, Marchi N, Janigro D | Epilepsia | 28199000 | Epilepsia | 2017 Apr | https://www.ncbi.nlm.nih.gov/pubmed/28199000 |
| Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease. | Popik W, Correa H, Khatua A, Aronoff DM, Alcendor DJ | Journal of translational science | 29977613 | J Transl Sci | 2019 Feb | https://www.ncbi.nlm.nih.gov/pubmed/29977613 |
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| Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. | Puvenna V, Brennan C, Shaw G, Yang C, Marchi N, Bazarian JJ, Merchant-Borna K, Janigro D | PloS one | 24806476 | PLoS One | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/24806476 |
| Polymeric stent materials dysregulate macrophage and endothelial cell functions: implications for coronary artery stent. | Wang X, Zachman AL, Chun YW, Shen FW, Hwang YS, Sung HJ | International journal of cardiology | 24820736 | Int J Cardiol | 2014 Jul 1 | https://www.ncbi.nlm.nih.gov/pubmed/24820736 |
| Femtosecond laser-patterned nanopore arrays for surface-mediated peptide treatment. | Zachman AL, Hofmeister LH, Costa L, Boire TC, Hwang YS, Hofmeister WH, Sung HJ | Nanomedicine : nanotechnology, biology, and medicine | 24090768 | Nanomedicine | 2014 Jan | https://www.ncbi.nlm.nih.gov/pubmed/24090768 |
| Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. | Brown JA, Pensabene V, Markov DA, Allwardt V, Neely MD, Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, Wikswo JP | Biomicrofluidics | 26576206 | Biomicrofluidics | 2015 Sep | https://www.ncbi.nlm.nih.gov/pubmed/26576206 |
| Zika Virus Infection of the Human Glomerular Cells: Implications for Viral Reservoirs and Renal Pathogenesis. | Alcendor DJ | The Journal of infectious diseases | 28398522 | J Infect Dis | 2017 Jul 15 | https://www.ncbi.nlm.nih.gov/pubmed/28398522 |
| Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells. | Lee JB, Balikov DA, Yang JW, Kim KS, Park HK, Kim JK, Kwon IK, Bellan LM, Sung HJ | Polymers | 29034114 | Polymers (Basel) | 2016 Jan | https://www.ncbi.nlm.nih.gov/pubmed/29034114 |
| Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. | Boussadia B, Ghosh C, Plaud C, Pascussi JM, de Bock F, Rousset MC, Janigro D, Marchi N | Neuroscience | 25280786 | Neuroscience | 2014 Dec 5 | https://www.ncbi.nlm.nih.gov/pubmed/25280786 |
| Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. | Ghosh C, Hossain M, Spriggs A, Ghosh A, Grant GA, Marchi N, Perucca E, Janigro D | Epilepsia | 25656284 | Epilepsia | 2015 Mar | https://www.ncbi.nlm.nih.gov/pubmed/25656284 |
| S100B blood levels and childhood trauma in adolescent inpatients. | Falcone T, Janigro D, Lovell R, Simon B, Brown CA, Herrera M, Myint AM, Anand A | Journal of psychiatric research | 25669696 | J Psychiatr Res | 2015 Mar | https://www.ncbi.nlm.nih.gov/pubmed/25669696 |
| Biology coming full circle: joining the whole and the parts. | Wikswo JP, Porter AP | Experimental biology and medicine (Maywood, N.J.) | 25583953 | Exp Biol Med (Maywood) | 2015 Jan | https://www.ncbi.nlm.nih.gov/pubmed/25583953 |
| A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches. | Janigro D, Iffland PH 2nd, Marchi N, Granata T | Epilepsia | 24001067 | Epilepsia | 2013 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24001067 |
| New immunological approaches in treating and diagnosing CNS diseases. | Guo K, Janigro D | Pharmaceutical patent analyst | 24237062 | Pharm Pat Anal | 2013 May | https://www.ncbi.nlm.nih.gov/pubmed/24237062 |
| Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies. 2. Electrospray Spectra of 3-Ring and 4-Ring Isomers. | Stow SM, Onifer TM, Forsythe JG, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM | Analytical chemistry | 25971782 | Anal Chem | 2015 Jun 16 | https://www.ncbi.nlm.nih.gov/pubmed/25971782 |
| Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels. | Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ | Biomaterials | 25154665 | Biomaterials | 2014 Dec | https://www.ncbi.nlm.nih.gov/pubmed/25154665 |
| Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia. | Brown JA, Sherrod SD, Goodwin CR, Brewer B, Yang L, Garbett KA, Li D, McLean JA, Wikswo JP, Mirnics K | Journal of neuroinflammation | 25374324 | J Neuroinflammation | 2014 Nov 6 | https://www.ncbi.nlm.nih.gov/pubmed/25374324 |
| Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier. | Janigro D | Epilepsia | 22612806 | Epilepsia | 2012 Jun | https://www.ncbi.nlm.nih.gov/pubmed/22612806 |
| A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box. | Cucullo L, Hossain M, Tierney W, Janigro D | BMC neuroscience | 23388041 | BMC Neurosci | 2013 Feb 6 | https://www.ncbi.nlm.nih.gov/pubmed/23388041 |
| Elucidation of adhesion-dependent spontaneous apoptosis in macrophages using phase separated PEG/polyurethane films. | Zachman AL, Page JM, Prabhakar G, Guelcher SA, Sung HJ | Acta biomaterialia | 23128157 | Acta Biomater | 2013 Feb | https://www.ncbi.nlm.nih.gov/pubmed/23128157 |
| Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes. | Chun YW, Balikov DA, Feaster TK, Williams CH, Sheng CC, Lee JB, Boire TC, Neely MD, Bellan LM, Ess KC, Bowman AB, Sung HJ, Hong CC | Biomaterials | 26204225 | Biomaterials | 2015 Oct | https://www.ncbi.nlm.nih.gov/pubmed/26204225 |
| Novel behavior of the chromatographic separation of linear and cyclic polymers. | Montenegro-Burke JR, Bennett JM, McLean JA, Hercules DM | Analytical and bioanalytical chemistry | 26637218 | Anal Bioanal Chem | 2016 Jan | https://www.ncbi.nlm.nih.gov/pubmed/26637218 |
| Ultrathin Polymer Membranes with Patterned, Micrometric Pores for Organs-on-Chips. | Pensabene V, Costa L, Terekhov AY, Gnecco JS, Wikswo JP, Hofmeister WH | ACS applied materials & interfaces | 27513606 | ACS Appl Mater Interfaces | 2016 Aug 31 | https://www.ncbi.nlm.nih.gov/pubmed/27513606 |
| Phage-display-guided nanocarrier targeting to atheroprone vasculature. | Hofmeister LH, Lee SH, Norlander AE, Montaniel KR, Chen W, Harrison DG, Sung HJ | ACS nano | 25768046 | ACS Nano | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/25768046 |
| In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4(+) T Lymphocytes. | Matta P, Sherrod SD, Marasco CC, Moore DJ, McLean JA, Weitkamp JH | Journal of immunology (Baltimore, Md. : 1950) | 28947540 | J Immunol | 2017 Nov 1 | https://www.ncbi.nlm.nih.gov/pubmed/28947540 |
| Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease. | Roach T, Alcendor DJ | Journal of neuroinflammation | 28253931 | J Neuroinflammation | 2017 Mar 3 | https://www.ncbi.nlm.nih.gov/pubmed/28253931 |
| Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode. | McKenzie JR, Cognata AC, Davis AN, Wikswo JP, Cliffel DE | Analytical chemistry | 26125545 | Anal Chem | 2015 Aug 4 | https://www.ncbi.nlm.nih.gov/pubmed/26125545 |
| IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study. | Wathen C, Janigro D | Epilepsia | 25099305 | Epilepsia | 2014 Aug | https://www.ncbi.nlm.nih.gov/pubmed/25099305 |
| Improving the clinical management of traumatic brain injury through the pharmacokinetic modeling of peripheral blood biomarkers. | Dadas A, Washington J, Marchi N, Janigro D | Fluids and barriers of the CNS | 27903281 | Fluids Barriers CNS | 2016 Nov 30 | https://www.ncbi.nlm.nih.gov/pubmed/27903281 |
| Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems. | Marasco CC, Goodwin CR, Winder DG, Schramm-Sapyta NL, McLean JA, Wikswo JP | Experimental biology and medicine (Maywood, N.J.) | 24903164 | Exp Biol Med (Maywood) | 2014 Nov | https://www.ncbi.nlm.nih.gov/pubmed/24903164 |
| Cancer Stem Cells under Hypoxia as a Chemoresistance Factor in Breast and Brain. | Crowder SW, Balikov DA, Hwang YS, Sung HJ | Current pathobiology reports | 24587979 | Curr Pathobiol Rep | 2014 Mar | https://www.ncbi.nlm.nih.gov/pubmed/24587979 |
| Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells. | Crowder SW, Prasai D, Rath R, Balikov DA, Bae H, Bolotin KI, Sung HJ | Nanoscale | 23592029 | Nanoscale | 2013 May 21 | https://www.ncbi.nlm.nih.gov/pubmed/23592029 |
| Scaling and systems biology for integrating multiple organs-on-a-chip. | Wikswo JP, Curtis EL, Eagleton ZE, Evans BC, Kole A, Hofmeister LH, Matloff WJ | Lab on a chip | 23828456 | Lab Chip | 2013 Sep 21 | https://www.ncbi.nlm.nih.gov/pubmed/23828456 |
| Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains. | Ghosh C, Hossain M, Puvenna V, Martinez-Gonzalez J, Alexopolous A, Janigro D, Marchi N | Epilepsia | 23865846 | Epilepsia | 2013 Sep | https://www.ncbi.nlm.nih.gov/pubmed/23865846 |
| Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts. | Shi M, Majumdar D, Gao Y, Brewer BM, Goodwin CR, McLean JA, Li D, Webb DJ | Lab on a chip | 23736663 | Lab Chip | 2013 Aug 7 | https://www.ncbi.nlm.nih.gov/pubmed/23736663 |
| Determination of ion mobility collision cross sections for unresolved isomeric mixtures using tandem mass spectrometry and chemometric deconvolution. | Harper B, Neumann EK, Stow SM, May JC, McLean JA, Solouki T | Analytica chimica acta | 27639144 | Anal Chim Acta | 2016 Oct 5 | https://www.ncbi.nlm.nih.gov/pubmed/27639144 |
| Detection of brain-directed autoantibodies in the serum of non-small cell lung cancer patients. | Banjara M, Ghosh C, Dadas A, Mazzone P, Janigro D | PloS one | 28746384 | PLoS One | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/28746384 |
| Pathophysiological implications of neurovascular P450 in brain disorders. | Ghosh C, Hossain M, Solanki J, Dadas A, Marchi N, Janigro D | Drug discovery today | 27312874 | Drug Discov Today | 2016 Oct | https://www.ncbi.nlm.nih.gov/pubmed/27312874 |
| Note: A single-chamber tool for plasma activation and surface functionalization in microfabrication. | Bowman AJ, Scherrer JR, Reiserer RS | The Review of scientific instruments | 26133881 | Rev Sci Instrum | 2015 Jun | https://www.ncbi.nlm.nih.gov/pubmed/26133881 |
| Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. | Xu L, Kliman M, Forsythe JG, Korade Z, Hmelo AB, Porter NA, McLean JA | Journal of the American Society for Mass Spectrometry | 25822928 | J Am Soc Mass Spectrom | 2015 Jun | https://www.ncbi.nlm.nih.gov/pubmed/25822928 |
| Ion mobility-mass spectrometry strategies for untargeted systems, synthetic, and chemical biology. | May JC, Goodwin CR, McLean JA | Current opinion in biotechnology | 25462629 | Curr Opin Biotechnol | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25462629 |
| Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. | Wilkerson I, Laban J, Mitchell JM, Sheibani N, Alcendor DJ | Journal of neuroinflammation | 25573478 | J Neuroinflammation | 2015 Jan 9 | https://www.ncbi.nlm.nih.gov/pubmed/25573478 |
| Bond-specific dissociation following excitation energy transfer for distance constraint determination in the gas phase. | Hendricks NG, Lareau NM, Stow SM, McLean JA, Julian RR | Journal of the American Chemical Society | 25174489 | J Am Chem Soc | 2014 Sep 24 | https://www.ncbi.nlm.nih.gov/pubmed/25174489 |
| Wavelet-based peak detection and a new charge inference procedure for MS/MS implemented in ProteoWizard's msConvert. | French WR, Zimmerman LJ, Schilling B, Gibson BW, Miller CA, Townsend RR, Sherrod SD, Goodwin CR, McLean JA, Tabb DL | Journal of proteome research | 25411686 | J Proteome Res | 2015 Feb 6 | https://www.ncbi.nlm.nih.gov/pubmed/25411686 |
| Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases. | Hines KM, Ballard BR, Marshall DR, McLean JA | Molecular bioSystems | 25212505 | Mol Biosyst | 2014 Nov | https://www.ncbi.nlm.nih.gov/pubmed/25212505 |
| Oligoproline-derived nanocarrier for dual stimuli-responsive gene delivery. | Gupta MK , Lee SH , Crowder SW , Wang X , Hofmeister LH , Nelson CE , Bellan LM , Duvall CL , Sung HJ | Journal of materials chemistry. B | 32262835 | J Mater Chem B | 2015 Sep 28 | https://www.ncbi.nlm.nih.gov/pubmed/32262835 |
| Transporters in drug-refractory epilepsy: clinical significance. | Marchi N, Gonzalez-Martinez J, Nguyen MT, Granata T, Janigro D | Clinical pharmacology and therapeutics | 20019694 | Clin Pharmacol Ther | 2010 Jan | https://www.ncbi.nlm.nih.gov/pubmed/20019694 |
| Patterned polymer matrix promotes stemness and cell-cell interaction of adult stem cells. | Hofmeister LH, Costa L, Balikov DA, Crowder SW, Terekhov A, Sung HJ, Hofmeister WH | Journal of biological engineering | 26464581 | J Biol Eng | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26464581 |
| Structural characterization of methylenedianiline regioisomers by ion mobility-mass spectrometry, tandem mass spectrometry, and computational strategies: I. Electrospray spectra of 2-ring isomers. | Forsythe JG, Stow SM, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM | Analytical chemistry | 24678803 | Anal Chem | 2014 May 6 | https://www.ncbi.nlm.nih.gov/pubmed/24678803 |
| What non-neuronal mechanisms should be studied to understand epileptic seizures? | Janigro D, Walker MC | Advances in experimental medicine and biology | 25012382 | Adv Exp Med Biol | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25012382 |
| Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer. | May JC, Goodwin CR, Lareau NM, Leaptrot KL, Morris CB, Kurulugama RT, Mordehai A, Klein C, Barry W, Darland E, Overney G, Imatani K, Stafford GC, Fjeldsted JC, McLean JA | Analytical chemistry | 24446877 | Anal Chem | 2014 Feb 18 | https://www.ncbi.nlm.nih.gov/pubmed/24446877 |
| Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. | Wikswo JP, Block FE 3rd, Cliffel DE, Goodwin CR, Marasco CC, Markov DA, McLean DL, McLean JA, McKenzie JR, Reiserer RS, Samson PC, Schaffer DK, Seale KT, Sherrod SD | IEEE transactions on bio-medical engineering | 23380852 | IEEE Trans Biomed Eng | 2013 Mar | https://www.ncbi.nlm.nih.gov/pubmed/23380852 |
| Systems-Wide High-Dimensional Data Acquisition and Informatics Using Structural Mass Spectrometry Strategies. | Sherrod SD, McLean JA | Clinical chemistry | 26453699 | Clin Chem | 2016 Jan | https://www.ncbi.nlm.nih.gov/pubmed/26453699 |
| Differential responses of induced pluripotent stem cell-derived cardiomyocytes to anisotropic strain depends on disease status. | Chun YW, Voyles DE, Rath R, Hofmeister LH, Boire TC, Wilcox H, Lee JH, Bellan LM, Hong CC, Sung HJ | Journal of biomechanics | 26476764 | J Biomech | 2015 Nov 5 | https://www.ncbi.nlm.nih.gov/pubmed/26476764 |
| Lipid profiling of polarized human monocyte-derived macrophages. | Montenegro-Burke JR, Sutton JA, Rogers LM, Milne GL, McLean JA, Aronoff DM | Prostaglandins & other lipid mediators | 27871801 | Prostaglandins Other Lipid Mediat | 2016 Dec | https://www.ncbi.nlm.nih.gov/pubmed/27871801 |
| Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. | Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP | Journal of neuroinflammation | 27955696 | J Neuroinflammation | 2016 Dec 12 | https://www.ncbi.nlm.nih.gov/pubmed/27955696 |
| Untargeted Metabolomics Strategies-Challenges and Emerging Directions. | Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA | Journal of the American Society for Mass Spectrometry | 27624161 | J Am Soc Mass Spectrom | 2016 Dec | https://www.ncbi.nlm.nih.gov/pubmed/27624161 |
| Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures. | Lizama-Manibusan BN, Klein S, McKenzie JR, Cliffel DE, McLaughlin B | ACS chemical neuroscience | 27504748 | ACS Chem Neurosci | 2016 Sep 21 | https://www.ncbi.nlm.nih.gov/pubmed/27504748 |
| Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge. | May JC, McLean JA | Annual review of analytical chemistry (Palo Alto, Calif.) | 27306312 | Annu Rev Anal Chem (Palo Alto Calif) | 2016 Jun 12 | https://www.ncbi.nlm.nih.gov/pubmed/27306312 |
| Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry. | Hines KM, May JC, McLean JA, Xu L | Analytical chemistry | 27321977 | Anal Chem | 2016 Jul 19 | https://www.ncbi.nlm.nih.gov/pubmed/27321977 |
| Ion mobility-mass spectrometry: time-dispersive instrumentation. | May JC, McLean JA | Analytical chemistry | 25526595 | Anal Chem | 2015 Feb 3 | https://www.ncbi.nlm.nih.gov/pubmed/25526595 |
| Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer. | May JC, Dodds JN, Kurulugama RT, Stafford GC, Fjeldsted JC, McLean JA | The Analyst | 26191544 | Analyst | 2015 Oct 21 | https://www.ncbi.nlm.nih.gov/pubmed/26191544 |
| Blood-brain barrier, bulk flow, and interstitial clearance in epilepsy. | Marchi N, Banjara M, Janigro D | Journal of neuroscience methods | 26093166 | J Neurosci Methods | 2016 Feb 15 | https://www.ncbi.nlm.nih.gov/pubmed/26093166 |
| Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues. | Karolak A, Markov DA, McCawley LJ, Rejniak KA | Journal of the Royal Society, Interface | 29367239 | J R Soc Interface | 2018 Jan | https://www.ncbi.nlm.nih.gov/pubmed/29367239 |
| Emulator-based Bayesian inference on non-proportional scintillation models by compton-edge probing. | Breitenmoser D, Cerutti F, Butterweck G, Kasprzak MM, Mayer S | Nature communications | 38012127 | Nat Commun | 2023 Nov 28 | https://www.ncbi.nlm.nih.gov/pubmed/38012127 |
| Three-dimensional filamentous human diseased cardiac tissue model. | Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE | Biomaterials | 24268663 | Biomaterials | 2014 Feb | https://www.ncbi.nlm.nih.gov/pubmed/24268663 |
| Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. | Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE | Stem cell research & therapy | 24565415 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565415 |
| WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue. | Loskill P, Sezhian T, Tharp KM, Lee-Montiel FT, Jeeawoody S, Reese WM, Zushin PH, Stahl A, Healy KE | Lab on a chip | 28418430 | Lab Chip | 2017 May 2 | https://www.ncbi.nlm.nih.gov/pubmed/28418430 |
| Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes. | Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S | Biotechnology and bioengineering | 29663322 | Biotechnol Bioeng | 2018 Aug | https://www.ncbi.nlm.nih.gov/pubmed/29663322 |
| Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. | Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR | Stem cell reports | 25254341 | Stem Cell Reports | 2014 Aug 12 | https://www.ncbi.nlm.nih.gov/pubmed/25254341 |
| Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. | Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE | Nature biomedical engineering | 31015724 | Nat Biomed Eng | 2018 Dec | https://www.ncbi.nlm.nih.gov/pubmed/31015724 |
| In vitro cardiac tissue models: Current status and future prospects. | Mathur A, Ma Z, Loskill P, Jeeawoody S, Healy KE | Advanced drug delivery reviews | 26428618 | Adv Drug Deliv Rev | 2016 Jan 15 | https://www.ncbi.nlm.nih.gov/pubmed/26428618 |
| Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs. | Liu Y, Sakolish C, Chen Z, Phan DTT, Bender RHF, Hughes CCW, Rusyn I | Toxicology | 32980478 | Toxicology | 2020 Dec 1 | https://www.ncbi.nlm.nih.gov/pubmed/32980478 |
| A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis. | Natividad-Diaz SL, Browne S, Jha AK, Ma Z, Hossainy S, Kurokawa YK, George SC, Healy KE | Biomaterials | 30583150 | Biomaterials | 2019 Feb | https://www.ncbi.nlm.nih.gov/pubmed/30583150 |
| Physiologically relevant organs on chips. | Yum K, Hong SG, Healy KE, Lee LP | Biotechnology journal | 24357624 | Biotechnol J | 2014 Jan | https://www.ncbi.nlm.nih.gov/pubmed/24357624 |
| Biophysics and dynamics of natural and engineered stem cell microenvironments. | Keung AJ, Healy KE, Kumar S, Schaffer DV | Wiley interdisciplinary reviews. Systems biology and medicine | 20836010 | Wiley Interdiscip Rev Syst Biol Med | 2010 Jan-Feb | https://www.ncbi.nlm.nih.gov/pubmed/20836010 |
| Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. | Ma X, Duan Y, Tschudy-Seney B, Roll G, Behbahan IS, Ahuja TP, Tolstikov V, Wang C, McGee J, Khoobyari S, Nolta JA, Willenbring H, Zern MA | Stem cells translational medicine | 23681950 | Stem Cells Transl Med | 2013 Jun | https://www.ncbi.nlm.nih.gov/pubmed/23681950 |
| Self-organizing human cardiac microchambers mediated by geometric confinement. | Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE | Nature communications | 26172574 | Nat Commun | 2015 Jul 14 | https://www.ncbi.nlm.nih.gov/pubmed/26172574 |
| Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity. | Wang C, Koo S, Park M, Vangelatos Z, Hoang P, Conklin BR, Grigoropoulos CP, Healy KE, Ma Z | Advanced healthcare materials | 32090507 | Adv Healthc Mater | 2020 Apr | https://www.ncbi.nlm.nih.gov/pubmed/32090507 |
| A therapy for liver failure found in the JNK yard. | Willenbring H, Grompe M | Cell | 23582318 | Cell | 2013 Apr 11 | https://www.ncbi.nlm.nih.gov/pubmed/23582318 |
| Transplantable liver organoids made from only three ingredients. | Willenbring H, Soto-Gutierrez A | Cell stem cell | 23910079 | Cell Stem Cell | 2013 Aug 1 | https://www.ncbi.nlm.nih.gov/pubmed/23910079 |
| Mouse liver repopulation with hepatocytes generated from human fibroblasts. | Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S | Nature | 24572354 | Nature | 2014 Apr 3 | https://www.ncbi.nlm.nih.gov/pubmed/24572354 |
| Human iPSC-based cardiac microphysiological system for drug screening applications. | Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE | Scientific reports | 25748532 | Sci Rep | 2015 Mar 9 | https://www.ncbi.nlm.nih.gov/pubmed/25748532 |
| Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. | Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR | Scientific reports | 27095412 | Sci Rep | 2016 Apr 20 | https://www.ncbi.nlm.nih.gov/pubmed/27095412 |
| Aquaporin 9 induction in human iPSC-derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency. | Laemmle A, Poms M, Hsu B, Borsuk M, Rüfenacht V, Robinson J, Sadowski MC, Nuoffer JM, Häberle J, Willenbring H | Hepatology (Baltimore, Md.) | 34786702 | Hepatology | 2022 Sep | https://www.ncbi.nlm.nih.gov/pubmed/34786702 |
| Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. | Hoang P, Wang J, Conklin BR, Healy KE, Ma Z | Nature protocols | 29543795 | Nat Protoc | 2018 Apr | https://www.ncbi.nlm.nih.gov/pubmed/29543795 |
| Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. | Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE | Tissue engineering. Part C, Methods | 25333967 | Tissue Eng Part C Methods | 2015 May | https://www.ncbi.nlm.nih.gov/pubmed/25333967 |
| Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication. | Alonzo LF, Moya ML, Shirure VS, George SC | Lab on a chip | 26190172 | Lab Chip | 2015 Sep 7 | https://www.ncbi.nlm.nih.gov/pubmed/26190172 |
| A three-dimensional in vitro model of tumor cell intravasation. | Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC | Integrative biology : quantitative biosciences from nano to macro | 24763498 | Integr Biol (Camb) | 2014 Jun | https://www.ncbi.nlm.nih.gov/pubmed/24763498 |
| A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening. | Heylman C, Sobrino A, Shirure VS, Hughes CC, George SC | Experimental biology and medicine (Maywood, N.J.) | 24740872 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24740872 |
| Microfluidic device to attain high spatial and temporal control of oxygen. | Lam SF, Shirure VS, Chu YE, Soetikno AG, George SC | PloS one | 30571786 | PLoS One | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30571786 |
| Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. | Shirure VS, Bi Y, Curtis MB, Lezia A, Goedegebuure MM, Goedegebuure SP, Aft R, Fields RC, George SC | Lab on a chip | 30393802 | Lab Chip | 2018 Dec 7 | https://www.ncbi.nlm.nih.gov/pubmed/30393802 |
| Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes. | Datta R, Heylman C, George SC, Gratton E | Biomedical optics express | 27231614 | Biomed Opt Express | 2016 May 1 | https://www.ncbi.nlm.nih.gov/pubmed/27231614 |
| 3D microtumors in vitro supported by perfused vascular networks. | Sobrino A, Phan DT, Datta R, Wang X, Hachey SJ, Romero-López M, Gratton E, Lee AP, George SC, Hughes CC | Scientific reports | 27549930 | Sci Rep | 2016 Aug 23 | https://www.ncbi.nlm.nih.gov/pubmed/27549930 |
| Vessel network formation in response to intermittent hypoxia is frequency dependent. | Ehsan SM, George SC | Journal of bioscience and bioengineering | 25735591 | J Biosci Bioeng | 2015 Sep | https://www.ncbi.nlm.nih.gov/pubmed/25735591 |
| Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. | Lee EK, Kurokawa YK, Tu R, George SC, Khine M | Scientific reports | 26139150 | Sci Rep | 2015 Jul 3 | https://www.ncbi.nlm.nih.gov/pubmed/26139150 |
| An integrated in vitro model of perfused tumor and cardiac tissue. | Moya M, Tran D, George SC | Stem cell research & therapy | 24565445 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565445 |
| Integrating in vitro organ-specific function with the microcirculation. | Moya ML, George SC | Current opinion in chemical engineering | 24729953 | Curr Opin Chem Eng | 2014 Feb 1 | https://www.ncbi.nlm.nih.gov/pubmed/24729953 |
| Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. | Wang X, Phan DT, Sobrino A, George SC, Hughes CC, Lee AP | Lab on a chip | 26616908 | Lab Chip | 2016 Jan 21 | https://www.ncbi.nlm.nih.gov/pubmed/26616908 |
| Applications of tumor chip technology. | Hachey SJ, Hughes CCW | Lab on a chip | 30156248 | Lab Chip | 2018 Sep 26 | https://www.ncbi.nlm.nih.gov/pubmed/30156248 |
| Executive summary of the 12th HHT international scientific conference. | Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ | Angiogenesis | 29147802 | Angiogenesis | 2018 Feb | https://www.ncbi.nlm.nih.gov/pubmed/29147802 |
| Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms. | Shirure VS, George SC | Lab on a chip | 28102869 | Lab Chip | 2017 Feb 14 | https://www.ncbi.nlm.nih.gov/pubmed/28102869 |
| Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components. | Merna N, Fung KM, Wang JJ, King CR, Hansen KC, Christman KL, George SC | Tissue engineering. Part A | 25926101 | Tissue Eng Part A | 2015 Aug | https://www.ncbi.nlm.nih.gov/pubmed/25926101 |
| The vascular niche in next generation microphysiological systems. | Ewald ML, Chen YH, Lee AP, Hughes CCW | Lab on a chip | 34396383 | Lab Chip | 2021 Sep 7 | https://www.ncbi.nlm.nih.gov/pubmed/34396383 |
| A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. | Hsu YH, Moya ML, Hughes CC, George SC, Lee AP | Lab on a chip | 23723013 | Lab Chip | 2013 Aug 7 | https://www.ncbi.nlm.nih.gov/pubmed/23723013 |
| Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. | Robertson C, Tran DD, George SC | Stem cells (Dayton, Ohio) | 23355363 | Stem Cells | 2013 May | https://www.ncbi.nlm.nih.gov/pubmed/23355363 |
| Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening. | Kurokawa YK, George SC | Advanced drug delivery reviews | 26212156 | Adv Drug Deliv Rev | 2016 Jan 15 | https://www.ncbi.nlm.nih.gov/pubmed/26212156 |
| Nonsteady state oxygen transport in engineered tissue: implications for design. | Ehsan SM, George SC | Tissue engineering. Part A | 23350630 | Tissue Eng Part A | 2013 Jun | https://www.ncbi.nlm.nih.gov/pubmed/23350630 |
| Microfluidic device to culture 3D in vitro human capillary networks. | Moya ML, Alonzo LF, George SC | Methods in molecular biology (Clifton, N.J.) | 24155229 | Methods Mol Biol | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/24155229 |
| An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. | Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW | Lab on a chip | 33605955 | Lab Chip | 2021 Apr 7 | https://www.ncbi.nlm.nih.gov/pubmed/33605955 |
| Tissue Engineering the Vascular Tree. | Traore MA, George SC | Tissue engineering. Part B, Reviews | 28799844 | Tissue Eng Part B Rev | 2017 Dec | https://www.ncbi.nlm.nih.gov/pubmed/28799844 |
| Automated detection and analysis of depolarization events in human cardiomyocytes using MaDEC. | Szymanska AF, Heylman C, Datta R, Gratton E, Nenadic Z | Computers in biology and medicine | 27281718 | Comput Biol Med | 2016 Aug 1 | https://www.ncbi.nlm.nih.gov/pubmed/27281718 |
| Fluorescence lifetime imaging of endogenous biomarker of oxidative stress. | Datta R, Alfonso-García A, Cinco R, Gratton E | Scientific reports | 25993434 | Sci Rep | 2015 May 20 | https://www.ncbi.nlm.nih.gov/pubmed/25993434 |
| Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity. | Weng KC, Kurokawa YK, Hajek BS, Paladin JA, Shirure VS, George SC | Tissue engineering. Part C, Methods | 31797733 | Tissue Eng Part C Methods | 2020 Jan | https://www.ncbi.nlm.nih.gov/pubmed/31797733 |
| Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis. | Shirure VS, Lezia A, Tao A, Alonzo LF, George SC | Angiogenesis | 28608153 | Angiogenesis | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/28608153 |
| Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems. | Kurokawa YK, Yin RT, Shang MR, Shirure VS, Moya ML, George SC | Tissue engineering. Part C, Methods | 28622076 | Tissue Eng Part C Methods | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28622076 |
| Organ-on-a-chip model of vascularized human bone marrow niches. | Glaser DE, Curtis MB, Sariano PA, Rollins ZA, Shergill BS, Anand A, Deely AM, Shirure VS, Anderson L, Lowen JM, Ng NR, Weilbaecher K, Link DC, George SC | Biomaterials | 34810038 | Biomaterials | 2022 Jan | https://www.ncbi.nlm.nih.gov/pubmed/34810038 |
| 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels. | Wang X, Phan DTT, George SC, Hughes CCW, Lee AP | Methods in molecular biology (Clifton, N.J.) | 28634954 | Methods Mol Biol | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/28634954 |
| Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface. | Phan DT, Bender RHF, Andrejecsk JW, Sobrino A, Hachey SJ, George SC, Hughes CC | Experimental biology and medicine (Maywood, N.J.) | 28195514 | Exp Biol Med (Maywood) | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/28195514 |
| Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. | Heylman C, Datta R, Sobrino A, George S, Gratton E | PloS one | 26695765 | PLoS One | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26695765 |
| Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images. | Urban G, Bache KM, Phan D, Sobrino A, Shmakov AK, Hachey SJ, Hughes C, Baldi P | IEEE/ACM transactions on computational biology and bioinformatics | 29993583 | IEEE/ACM Trans Comput Biol Bioinform | 2019 May-Jun | https://www.ncbi.nlm.nih.gov/pubmed/29993583 |
| A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. | Phan DTT, Wang X, Craver BM, Sobrino A, Zhao D, Chen JC, Lee LYN, George SC, Lee AP, Hughes CCW | Lab on a chip | 28092382 | Lab Chip | 2017 Jan 31 | https://www.ncbi.nlm.nih.gov/pubmed/28092382 |
| Cancer-associated fibroblasts support vascular growth through mechanical force. | Sewell-Loftin MK, Bayer SVH, Crist E, Hughes T, Joison SM, Longmore GD, George SC | Scientific reports | 28974764 | Sci Rep | 2017 Oct 3 | https://www.ncbi.nlm.nih.gov/pubmed/28974764 |
| Rational engineering of lung alveolar epithelium. | Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski N, Herzog EL, Niklason LE | NPJ Regenerative medicine | 37117221 | NPJ Regen Med | 2023 Apr 28 | https://www.ncbi.nlm.nih.gov/pubmed/37117221 |
| HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. | Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, Linke WA, Chen CS, Seidman JG, Seidman CE | Science (New York, N.Y.) | 26315439 | Science | 2015 Aug 28 | https://www.ncbi.nlm.nih.gov/pubmed/26315439 |
| The magic touch: endothelial cells muscle-up adipose. | Martin KA, Hirschi KK | Circulation research | 25301822 | Circ Res | 2014 Oct 10 | https://www.ncbi.nlm.nih.gov/pubmed/25301822 |
| Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues. | Feric NT, Radisic M | Advanced drug delivery reviews | 25956564 | Adv Drug Deliv Rev | 2016 Jan 15 | https://www.ncbi.nlm.nih.gov/pubmed/25956564 |
| Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. | Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR | Arteriosclerosis, thrombosis, and vascular biology | 27834690 | Arterioscler Thromb Vasc Biol | 2017 Feb | https://www.ncbi.nlm.nih.gov/pubmed/27834690 |
| High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro. | Shan J, Logan DJ, Root DE, Carpenter AE, Bhatia SN | Journal of biomolecular screening | 27650791 | J Biomol Screen | 2016 Oct | https://www.ncbi.nlm.nih.gov/pubmed/27650791 |
| Laminar flow downregulates Notch activity to promote lymphatic sprouting. | Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK | The Journal of clinical investigation | 28263185 | J Clin Invest | 2017 Apr 3 | https://www.ncbi.nlm.nih.gov/pubmed/28263185 |
| The molecular basis of endothelial cell plasticity. | Dejana E, Hirschi KK, Simons M | Nature communications | 28181491 | Nat Commun | 2017 Feb 9 | https://www.ncbi.nlm.nih.gov/pubmed/28181491 |
| Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. | Ronaldson-Bouchard K, Vunjak-Novakovic G | Cell stem cell | 29499151 | Cell Stem Cell | 2018 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/29499151 |
| Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. | Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE | Cell transplantation | 28901188 | Cell Transplant | 2017 Aug | https://www.ncbi.nlm.nih.gov/pubmed/28901188 |
| Tissue engineering of human hair follicles using a biomimetic developmental approach. | Abaci HE, Coffman A, Doucet Y, Chen J, Jacków J, Wang E, Guo Z, Shin JU, Jahoda CA, Christiano AM | Nature communications | 30546011 | Nat Commun | 2018 Dec 13 | https://www.ncbi.nlm.nih.gov/pubmed/30546011 |
| Portable bioreactor for perfusion and electrical stimulation of engineered cardiac tissue. | Tandon N, Taubman A, Cimetta E, Saccenti L, Vunjak-Novakovic G | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference | 24111161 | Annu Int Conf IEEE Eng Med Biol Soc | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24111161 |
| Bioreactor engineering of stem cell environments. | Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G | Biotechnology advances | 23531529 | Biotechnol Adv | 2013 Nov 15 | https://www.ncbi.nlm.nih.gov/pubmed/23531529 |
| Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. | Liu B, Lee BW, Nakanishi K, Villasante A, Williamson R, Metz J, Kim J, Kanai M, Bi L, Brown K, Di Paolo G, Homma S, Sims PA, Topkara VK, Vunjak-Novakovic G | Nature biomedical engineering | 30271672 | Nat Biomed Eng | 2018 May | https://www.ncbi.nlm.nih.gov/pubmed/30271672 |
| Biomimetic on-a-chip platforms for studying cancer metastasis. | Lee E, Song HG, Chen CS | Current opinion in chemical engineering | 27570735 | Curr Opin Chem Eng | 2016 Feb | https://www.ncbi.nlm.nih.gov/pubmed/27570735 |
| Patterning vascular networks in vivo for tissue engineering applications. | Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS | Tissue engineering. Part C, Methods | 25390971 | Tissue Eng Part C Methods | 2015 May | https://www.ncbi.nlm.nih.gov/pubmed/25390971 |
| Myocardial tissue engineering: in vitro models. | Vunjak Novakovic G, Eschenhagen T, Mummery C | Cold Spring Harbor perspectives in medicine | 24591534 | Cold Spring Harb Perspect Med | 2014 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/24591534 |
| Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. | Shlomai A, Schwartz RE, Ramanan V, Bhatta A, de Jong YP, Bhatia SN, Rice CM | Proceedings of the National Academy of Sciences of the United States of America | 25092305 | Proc Natl Acad Sci U S A | 2014 Aug 19 | https://www.ncbi.nlm.nih.gov/pubmed/25092305 |
| Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening. | Zhao R, Chen CS, Reich DH | Biomaterials | 24630092 | Biomaterials | 2014 Jun | https://www.ncbi.nlm.nih.gov/pubmed/24630092 |
| Bioengineered Models of Solid Human Tumors for Cancer Research. | Marturano-Kruik A, Villasante A, Vunjak-Novakovic G | Methods in molecular biology (Clifton, N.J.) | 27115504 | Methods Mol Biol | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/27115504 |
| Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification. | Logan DJ, Shan J, Bhatia SN, Carpenter AE | Methods (San Diego, Calif.) | 26687239 | Methods | 2016 Mar 1 | https://www.ncbi.nlm.nih.gov/pubmed/26687239 |
| Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety. | Chramiec A, Teles D, Yeager K, Marturano-Kruik A, Pak J, Chen T, Hao L, Wang M, Lock R, Tavakol DN, Lee MB, Kim J, Ronaldson-Bouchard K, Vunjak-Novakovic G | Lab on a chip | 32955072 | Lab Chip | 2020 Nov 24 | https://www.ncbi.nlm.nih.gov/pubmed/32955072 |
| Endothelial Cell Differentiation and Hemogenic Specification. | Aragon JW, Hirschi KK | Cold Spring Harbor perspectives in medicine | 35193895 | Cold Spring Harb Perspect Med | 2022 Jul 29 | https://www.ncbi.nlm.nih.gov/pubmed/35193895 |
| Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. | Genet N, Hirschi KK | Regenerative medicine | 34498495 | Regen Med | 2021 Sep | https://www.ncbi.nlm.nih.gov/pubmed/34498495 |
| Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. | Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK | Circulation | 38126211 | Circulation | 2024 Mar 19 | https://www.ncbi.nlm.nih.gov/pubmed/38126211 |
| MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. | Wu Y, Paila U, Genet G, Hirschi KK | Developmental cell | 37295435 | Dev Cell | 2023 Jul 24 | https://www.ncbi.nlm.nih.gov/pubmed/37295435 |
| HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. | Vunjak-Novakovic G, Bhatia S, Chen C, Hirschi K | Stem cell research & therapy | 24565063 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565063 |
| Label-free evaluation of angiogenic sprouting in microengineered devices using ultrahigh-resolution optical coherence microscopy. | Li F, Xu T, Nguyen DH, Huang X, Chen CS, Zhou C | Journal of biomedical optics | 24395588 | J Biomed Opt | 2014 Jan | https://www.ncbi.nlm.nih.gov/pubmed/24395588 |
| Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue. | Lee BW, Liu B, Pluchinsky A, Kim N, Eng G, Vunjak-Novakovic G | Advanced healthcare materials | 26865105 | Adv Healthc Mater | 2016 Apr 20 | https://www.ncbi.nlm.nih.gov/pubmed/26865105 |
| In vitro Models of Ischemia-Reperfusion Injury. | Chen T, Vunjak-Novakovic G | Regenerative engineering and translational medicine | 30393757 | Regen Eng Transl Med | 2018 Sep | https://www.ncbi.nlm.nih.gov/pubmed/30393757 |
| Next generation human skin constructs as advanced tools for drug development. | Abaci HE, Guo Z, Doucet Y, Jacków J, Christiano A | Experimental biology and medicine (Maywood, N.J.) | 28592171 | Exp Biol Med (Maywood) | 2017 Nov | https://www.ncbi.nlm.nih.gov/pubmed/28592171 |
| Biomechanical regulation of drug sensitivity in an engineered model of human tumor. | Marturano-Kruik A, Villasante A, Yaeger K, Ambati SR, Chramiec A, Raimondi MT, Vunjak-Novakovic G | Biomaterials | 29040875 | Biomaterials | 2018 Jan | https://www.ncbi.nlm.nih.gov/pubmed/29040875 |
| A DNA-based molecular probe for optically reporting cellular traction forces. | Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS | Nature methods | 25306545 | Nat Methods | 2014 Dec | https://www.ncbi.nlm.nih.gov/pubmed/25306545 |
| Macrophages modulate engineered human tissues for enhanced vascularization and healing. | Spiller KL, Freytes DO, Vunjak-Novakovic G | Annals of biomedical engineering | 25331098 | Ann Biomed Eng | 2015 Mar | https://www.ncbi.nlm.nih.gov/pubmed/25331098 |
| Cell and tissue engineering for liver disease. | Bhatia SN, Underhill GH, Zaret KS, Fox IJ | Science translational medicine | 25031271 | Sci Transl Med | 2014 Jul 16 | https://www.ncbi.nlm.nih.gov/pubmed/25031271 |
| Bioengineered tumors. | Villasante A, Vunjak-Novakovic G | Bioengineered | 25616977 | Bioengineered | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/25616977 |
| Development of a new method for the isolation and culture of pulmonary arterial endothelial cells from rat pulmonary arteries. | Peng G, Wen X, Shi Y, Jiang Y, Hu G, Zhou Y, Ran P | Journal of vascular research | 24192526 | J Vasc Res | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24192526 |
| Isolation of Murine Embryonic Hemogenic Endothelial Cells. | Fang JS, Gritz EC, Marcelo KL, Hirschi KK | Journal of visualized experiments : JoVE | 27341393 | J Vis Exp | 2016 Jun 17 | https://www.ncbi.nlm.nih.gov/pubmed/27341393 |
| The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. | Chavkin NW, Sano S, Wang Y, Oshima K, Ogawa H, Horitani K, Sano M, MacLauchlan S, Nelson A, Setia K, Vippa T, Watanabe Y, Saucerman JJ, Hirschi KK, Gokce N, Walsh K | Journal of the American Heart Association | 34155901 | J Am Heart Assoc | 2021 Jul 6 | https://www.ncbi.nlm.nih.gov/pubmed/34155901 |
| Non-destructive vacuum-assisted measurement of lung elastic modulus. | Chen J, Mir M, Pinezich MR, O'Neill JD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G, Huang SXL, Kim J | Acta biomaterialia | 34192570 | Acta Biomater | 2021 Sep 1 | https://www.ncbi.nlm.nih.gov/pubmed/34192570 |
| Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. | Eng G, Lee BW, Protas L, Gagliardi M, Brown K, Kass RS, Keller G, Robinson RB, Vunjak-Novakovic G | Nature communications | 26785135 | Nat Commun | 2016 Jan 19 | https://www.ncbi.nlm.nih.gov/pubmed/26785135 |
| "The state of the heart": Recent advances in engineering human cardiac tissue from pluripotent stem cells. | Sirabella D, Cimetta E, Vunjak-Novakovic G | Experimental biology and medicine (Maywood, N.J.) | 26069271 | Exp Biol Med (Maywood) | 2015 Aug | https://www.ncbi.nlm.nih.gov/pubmed/26069271 |
| Tissue-Engineering for the Study of Cardiac Biomechanics. | Ma SP, Vunjak-Novakovic G | Journal of biomechanical engineering | 26720588 | J Biomech Eng | 2016 Feb | https://www.ncbi.nlm.nih.gov/pubmed/26720588 |
| Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model. | Villasante A, Marturano-Kruik A, Ambati SR, Liu Z, Godier-Furnemont A, Parsa H, Lee BW, Moore MA, Vunjak-Novakovic G | Theranostics | 27279906 | Theranostics | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/27279906 |
| Modeling tumor microenvironments using custom-designed biomaterial scaffolds. | Liu Z, Vunjak-Novakovic G | Current opinion in chemical engineering | 27152253 | Curr Opin Chem Eng | 2016 Feb | https://www.ncbi.nlm.nih.gov/pubmed/27152253 |
| Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. | McCurley A, Alimperti S, Campos-Bilderback SB, Sandoval RM, Calvino JE, Reynolds TL, Quigley C, Mugford JW, Polacheck WJ, Gomez IG, Dovey J, Marsh G, Huang A, Qian F, Weinreb PH, Dolinski BM, Moore S, Duffield JS, Chen CS, Molitoris BA, Violette SM, Crackower MA | Journal of the American Society of Nephrology : JASN | 28062569 | J Am Soc Nephrol | 2017 Jun | https://www.ncbi.nlm.nih.gov/pubmed/28062569 |
| Microfabricated blood vessels for modeling the vascular transport barrier. | Polacheck WJ, Kutys ML, Tefft JB, Chen CS | Nature protocols | 30953042 | Nat Protoc | 2019 May | https://www.ncbi.nlm.nih.gov/pubmed/30953042 |
| Bioengineering methods for myocardial regeneration. | Parsa H, Ronaldson K, Vunjak-Novakovic G | Advanced drug delivery reviews | 26150344 | Adv Drug Deliv Rev | 2016 Jan 15 | https://www.ncbi.nlm.nih.gov/pubmed/26150344 |
| Natural cardiac extracellular matrix hydrogels for cultivation of human stem cell-derived cardiomyocytes. | Freytes DO, O'Neill JD, Duan-Arnold Y, Wrona EA, Vunjak-Novakovic G | Methods in molecular biology (Clifton, N.J.) | 25070328 | Methods Mol Biol | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25070328 |
| Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. | Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V | Cell | 37167971 | Cell | 2023 May 25 | https://www.ncbi.nlm.nih.gov/pubmed/37167971 |
| Microscale technologies for regulating human stem cell differentiation. | Cimetta E, Vunjak-Novakovic G | Experimental biology and medicine (Maywood, N.J.) | 24737735 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24737735 |
| Physical influences on stem cells. | Vunjak-Novakovic G | Stem cell research & therapy | 24476419 | Stem Cell Res Ther | 2013 Dec 24 | https://www.ncbi.nlm.nih.gov/pubmed/24476419 |
| The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine. | Martins AM, Vunjak-Novakovic G, Reis RL | Stem cell reviews and reports | 24425421 | Stem Cell Rev Rep | 2014 Apr | https://www.ncbi.nlm.nih.gov/pubmed/24425421 |
| Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells. | Cimetta E, Sirabella D, Yeager K, Davidson K, Simon J, Moon RT, Vunjak-Novakovic G | Lab on a chip | 23232509 | Lab Chip | 2013 Feb 7 | https://www.ncbi.nlm.nih.gov/pubmed/23232509 |
| Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. | Nguyen DH, Stapleton SC, Yang MT, Cha SS, Choi CK, Galie PA, Chen CS | Proceedings of the National Academy of Sciences of the United States of America | 23569284 | Proc Natl Acad Sci U S A | 2013 Apr 23 | https://www.ncbi.nlm.nih.gov/pubmed/23569284 |
| Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. | Baker BM, Trappmann B, Stapleton SC, Toro E, Chen CS | Lab on a chip | 23787488 | Lab Chip | 2013 Aug 21 | https://www.ncbi.nlm.nih.gov/pubmed/23787488 |
| Bioengineering heart tissue for in vitro testing. | Cimetta E, Godier-Furnémont A, Vunjak-Novakovic G | Current opinion in biotechnology | 23932513 | Curr Opin Biotechnol | 2013 Oct | https://www.ncbi.nlm.nih.gov/pubmed/23932513 |
| Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. | Song HG, Lammers A, Sundaram S, Rubio L, Chen AX, Li L, Eyckmans J, Bhatia SN, Chen CS | Advanced functional materials | 33613149 | Adv Funct Mater | 2020 Nov 25 | https://www.ncbi.nlm.nih.gov/pubmed/33613149 |
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| Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma. | Villasante A, Sakaguchi K, Kim J, Cheung NK, Nakayama M, Parsa H, Okano T, Shimizu T, Vunjak-Novakovic G | Theranostics | 29158813 | Theranostics | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/29158813 |
| A non-canonical Notch complex regulates adherens junctions and vascular barrier function. | Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS | Nature | 29160307 | Nature | 2017 Dec 14 | https://www.ncbi.nlm.nih.gov/pubmed/29160307 |
| Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. | Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS | Proceedings of the National Academy of Sciences of the United States of America | 28765370 | Proc Natl Acad Sci U S A | 2017 Aug 15 | https://www.ncbi.nlm.nih.gov/pubmed/28765370 |
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| Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. | Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN | Stem cell reports | 25660406 | Stem Cell Reports | 2015 Mar 10 | https://www.ncbi.nlm.nih.gov/pubmed/25660406 |
| Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. | Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK | Cell reports | 25310984 | Cell Rep | 2014 Oct 23 | https://www.ncbi.nlm.nih.gov/pubmed/25310984 |
| A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. | Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS | Science advances | 31489365 | Sci Adv | 2019 Aug | https://www.ncbi.nlm.nih.gov/pubmed/31489365 |
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| Human bone perivascular niche-on-a-chip for studying metastatic colonization. | Marturano-Kruik A, Nava MM, Yeager K, Chramiec A, Hao L, Robinson S, Guo E, Raimondi MT, Vunjak-Novakovic G | Proceedings of the National Academy of Sciences of the United States of America | 29363599 | Proc Natl Acad Sci U S A | 2018 Feb 6 | https://www.ncbi.nlm.nih.gov/pubmed/29363599 |
| Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. | Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK | Nature communications | 29247167 | Nat Commun | 2017 Dec 15 | https://www.ncbi.nlm.nih.gov/pubmed/29247167 |
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| milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues. | Tamargo MA, Nash TR, Fleischer S, Kim Y, Vila OF, Yeager K, Summers M, Zhao Y, Lock R, Chavez M, Costa T, Vunjak-Novakovic G | ACS biomaterials science & engineering | 34668692 | ACS Biomater Sci Eng | 2021 Nov 8 | https://www.ncbi.nlm.nih.gov/pubmed/34668692 |
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| Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. | Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE | Cell reports | 28009297 | Cell Rep | 2016 Dec 20 | https://www.ncbi.nlm.nih.gov/pubmed/28009297 |
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| A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro. | Smith AS, Long CJ, Pirozzi K, Najjar S, McAleer C, Vandenburgh HH, Hickman JJ | Journal of biotechnology | 24909944 | J Biotechnol | 2014 Sep 20 | https://www.ncbi.nlm.nih.gov/pubmed/24909944 |
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| Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure. | Sung JH, Srinivasan B, Esch MB, McLamb WT, Bernabini C, Shuler ML, Hickman JJ | Experimental biology and medicine (Maywood, N.J.) | 24951471 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24951471 |
| Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening. | Wang YI, Abaci HE, Shuler ML | Biotechnology and bioengineering | 27399645 | Biotechnol Bioeng | 2017 Jan | https://www.ncbi.nlm.nih.gov/pubmed/27399645 |
| A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. | Chen HJ, Miller P, Shuler ML | Lab on a chip | 29881844 | Lab Chip | 2018 Jul 10 | https://www.ncbi.nlm.nih.gov/pubmed/29881844 |
| Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems. | Berry BJ, Akanda N, Smith AS, Long CJ, Schnepper MT, Guo X, Hickman JJ | Biotechnology progress | 26317319 | Biotechnol Prog | 2015 Nov-Dec | https://www.ncbi.nlm.nih.gov/pubmed/26317319 |
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| Rat hepatocyte culture model of macrosteatosis: effect of macrosteatosis induction and reversal on viability and liver-specific function. | Nativ NI, Yarmush G, Chen A, Dong D, Henry SD, Guarrera JV, Klein KM, Maguire T, Schloss R, Berthiaume F, Yarmush ML | Journal of hepatology | 23872604 | J Hepatol | 2013 Dec | https://www.ncbi.nlm.nih.gov/pubmed/23872604 |
| Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment. | Laronda MM, Burdette JE, Kim J, Woodruff TK | Stem cell research & therapy | 24565375 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565375 |
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| Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells. | Gledhill K, Guo Z, Umegaki-Arao N, Higgins CA, Itoh M, Christiano AM | PloS one | 26308443 | PLoS One | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26308443 |
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| Building a microphysiological skin model from induced pluripotent stem cells. | Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AM | Stem cell research & therapy | 24564920 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24564920 |
| Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs). | Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AM | PloS one | 24147053 | PLoS One | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24147053 |
| Engineering human skin model innervated with itch sensory neuron-like cells differentiated from induced pluripotent stem cells. | Guo Z, Tong CK, Jacków J, Doucet YS, Abaci HE, Zeng W, Hansen C, Hayashi R, DeLorenzo D, Rami A, Pappalardo A, Lumpkin EA, Christiano AM | Bioengineering & translational medicine | 35111948 | Bioeng Transl Med | 2022 Jan | https://www.ncbi.nlm.nih.gov/pubmed/35111948 |
| Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use. | Nichols JE, Niles JA, Vega SP, Argueta LB, Eastaway A, Cortiella J | Experimental biology and medicine (Maywood, N.J.) | 24962174 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24962174 |
| Production and transplantation of bioengineered lung into a large-animal model. | Nichols JE, La Francesca S, Niles JA, Vega SP, Argueta LB, Frank L, Christiani DC, Pyles RB, Himes BE, Zhang R, Li S, Sakamoto J, Rhudy J, Hendricks G, Begarani F, Liu X, Patrikeev I, Pal R, Usheva E, Vargas G, Miller A, Woodson L, Wacher A, Grimaldo M, Weaver D, Mlcak R, Cortiella J | Science translational medicine | 30068570 | Sci Transl Med | 2018 Aug 1 | https://www.ncbi.nlm.nih.gov/pubmed/30068570 |
| Production and assessment of decellularized pig and human lung scaffolds. | Nichols JE, Niles J, Riddle M, Vargas G, Schilagard T, Ma L, Edward K, La Francesca S, Sakamoto J, Vega S, Ogadegbe M, Mlcak R, Deyo D, Woodson L, McQuitty C, Lick S, Beckles D, Melo E, Cortiella J | Tissue engineering. Part A | 23638920 | Tissue Eng Part A | 2013 Sep | https://www.ncbi.nlm.nih.gov/pubmed/23638920 |
| Novel in vitro respiratory models to study lung development, physiology, pathology and toxicology. | Nichols JE, Niles JA, Vega SP, Cortiella J | Stem cell research & therapy | 24565038 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565038 |
| Platforms to test the temporospatial capabilities of carrier systems in delivering growth factors to benefit vascular bioengineering. | Argueta LB, Niles JA, Sakamoto J, Liu X, Vega SP, Frank L, Paessler M, Cortiella J, Nichols JE | Nanomedicine : nanotechnology, biology, and medicine | 34147665 | Nanomedicine | 2021 Aug | https://www.ncbi.nlm.nih.gov/pubmed/34147665 |
| Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. | Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK | Methods in molecular biology (Clifton, N.J.) | 28361480 | Methods Mol Biol | 2019 | https://www.ncbi.nlm.nih.gov/pubmed/28361480 |
| Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. | Yin J, Tse CM, Avula LR, Singh V, Foulke-Abel J, de Jonge HR, Donowitz M | Cellular and molecular gastroenterology and hepatology | 29930980 | Cell Mol Gastroenterol Hepatol | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29930980 |
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| Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. | In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O | Cellular and molecular gastroenterology and hepatology | 26855967 | Cell Mol Gastroenterol Hepatol | 2016 Jan 1 | https://www.ncbi.nlm.nih.gov/pubmed/26855967 |
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| The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. | Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M | Annual review of physiology | 28192061 | Annu Rev Physiol | 2017 Feb 10 | https://www.ncbi.nlm.nih.gov/pubmed/28192061 |
| cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. | Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M | Cellular and molecular gastroenterology and hepatology | 30659943 | Cell Mol Gastroenterol Hepatol | 2019 | https://www.ncbi.nlm.nih.gov/pubmed/30659943 |
| Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling. | Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M | American journal of physiology. Cell physiology | 24760985 | Am J Physiol Cell Physiol | 2014 Jul 1 | https://www.ncbi.nlm.nih.gov/pubmed/24760985 |
| Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. | Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M | The Journal of biological chemistry | 26677228 | J Biol Chem | 2016 Feb 19 | https://www.ncbi.nlm.nih.gov/pubmed/26677228 |
| Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. | Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK | Journal of virology | 26446608 | J Virol | 2016 Jan 1 | https://www.ncbi.nlm.nih.gov/pubmed/26446608 |
| Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. | Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK | Cellular and molecular gastroenterology and hepatology | 29675450 | Cell Mol Gastroenterol Hepatol | 2018 Mar | https://www.ncbi.nlm.nih.gov/pubmed/29675450 |
| Gastrointestinal microphysiological systems. | Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK | Experimental biology and medicine (Maywood, N.J.) | 28534432 | Exp Biol Med (Maywood) | 2017 Oct | https://www.ncbi.nlm.nih.gov/pubmed/28534432 |
| A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. | Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK | Proceedings of the National Academy of Sciences of the United States of America | 28069942 | Proc Natl Acad Sci U S A | 2017 Jan 24 | https://www.ncbi.nlm.nih.gov/pubmed/28069942 |
| Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres. | Abreu CM, Gama L, Krasemann S, Chesnut M, Odwin-Dacosta S, Hogberg HT, Hartung T, Pamies D | Frontiers in microbiology | 30619100 | Front Microbiol | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/30619100 |
| Biological and medical applications of a brain-on-a-chip. | Pamies D, Hartung T, Hogberg HT | Experimental biology and medicine (Maywood, N.J.) | 24912505 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24912505 |
| 3D - a new dimension of in vitro research. | Hartung T | Advanced drug delivery reviews | 24721291 | Adv Drug Deliv Rev | 2014 Apr | https://www.ncbi.nlm.nih.gov/pubmed/24721291 |
| Rotenone exerts developmental neurotoxicity in a human brain spheroid model. | Pamies D, Block K, Lau P, Gribaldo L, Pardo CA, Barreras P, Smirnova L, Wiersma D, Zhao L, Harris G, Hartung T, Hogberg HT | Toxicology and applied pharmacology | 29428530 | Toxicol Appl Pharmacol | 2018 Sep 1 | https://www.ncbi.nlm.nih.gov/pubmed/29428530 |
| State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. | Alépée N, Bahinski A, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG | ALTEX | 25027500 | ALTEX | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25027500 |
| Perspectives on In Vitro to In Vivo Extrapolations. | Hartung T | Applied in vitro toxicology | 31890748 | Appl In Vitro Toxicol | 2018 Dec 1 | https://www.ncbi.nlm.nih.gov/pubmed/31890748 |
| Look back in anger - what clinical studies tell us about preclinical work. | Hartung T | ALTEX | 23861075 | ALTEX | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/23861075 |
| Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. | Coulter JB, O'Driscoll CM, Bressler JP | The Journal of biological chemistry | 23940045 | J Biol Chem | 2013 Oct 4 | https://www.ncbi.nlm.nih.gov/pubmed/23940045 |
| Mechanistic validation. | Hartung T, Hoffmann S, Stephens M | ALTEX | 23665802 | ALTEX | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/23665802 |
| Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity. | Pamies D, Wiersma D, Katt ME, Zhao L, Burtscher J, Harris G, Smirnova L, Searson PC, Hartung T, Hogberg HT | Neurobiology of disease | 35398340 | Neurobiol Dis | 2022 Jul | https://www.ncbi.nlm.nih.gov/pubmed/35398340 |
| A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity. | Pamies D, Barreras P, Block K, Makri G, Kumar A, Wiersma D, Smirnova L, Zang C, Bressler J, Christian KM, Harris G, Ming GL, Berlinicke CJ, Kyro K, Song H, Pardo CA, Hartung T, Hogberg HT | ALTEX | 27883356 | ALTEX | 2017 | https://www.ncbi.nlm.nih.gov/pubmed/27883356 |
| 3D Differentiation of LUHMES Cell Line to Study Recovery and Delayed Neurotoxic Effects. | Harris G, Hogberg H, Hartung T, Smirnova L | Current protocols in toxicology | 28777440 | Curr Protoc Toxicol | 2017 Aug 4 | https://www.ncbi.nlm.nih.gov/pubmed/28777440 |
| Mapping the human toxome by systems toxicology. | Bouhifd M, Hogberg HT, Kleensang A, Maertens A, Zhao L, Hartung T | Basic & clinical pharmacology & toxicology | 24443875 | Basic Clin Pharmacol Toxicol | 2014 Jul | https://www.ncbi.nlm.nih.gov/pubmed/24443875 |
| 21st Century Cell Culture for 21st Century Toxicology. | Pamies D, Hartung T | Chemical research in toxicology | 28092941 | Chem Res Toxicol | 2017 Jan 17 | https://www.ncbi.nlm.nih.gov/pubmed/28092941 |
| A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis. | Smirnova L, Harris G, Delp J, Valadares M, Pamies D, Hogberg HT, Waldmann T, Leist M, Hartung T | Archives of toxicology | 26647301 | Arch Toxicol | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/26647301 |
| Toward a 3D model of human brain development for studying gene/environment interactions. | Hogberg HT, Bressler J, Christian KM, Harris G, Makri G, O'Driscoll C, Pamies D, Smirnova L, Wen Z, Hartung T | Stem cell research & therapy | 24564953 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24564953 |
| 3S - Systematic, systemic, and systems biology and toxicology. | Smirnova L, Kleinstreuer N, Corvi R, Levchenko A, Fitzpatrick SC, Hartung T | ALTEX | 29677694 | ALTEX | 2018 | https://www.ncbi.nlm.nih.gov/pubmed/29677694 |
| International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. | Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Axelstad M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks MF, Ylikomi T, Fritsche E | Archives of toxicology | 25618548 | Arch Toxicol | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25618548 |
| Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. | Eicher AK, Kechele DO, Sundaram N, Berns HM, Poling HM, Haines LE, Sanchez JG, Kishimoto K, Krishnamurthy M, Han L, Zorn AM, Helmrath MA, Wells JM | Cell stem cell | 34856121 | Cell Stem Cell | 2022 Jan 6 | https://www.ncbi.nlm.nih.gov/pubmed/34856121 |
| Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. | Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM | Nature medicine | 27869805 | Nat Med | 2017 Jan | https://www.ncbi.nlm.nih.gov/pubmed/27869805 |
| An in vivo model of human small intestine using pluripotent stem cells. | Watson CL, Mahe MM, Múnera J, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y, Grabowski G, Finkbeiner SR, Spence JR, Shroyer NF, Wells JM, Helmrath MA | Nature medicine | 25326803 | Nat Med | 2014 Nov | https://www.ncbi.nlm.nih.gov/pubmed/25326803 |
| Developmental biology. Regional identity of gut stem cells--one gene to rule them all. | Wells JM | Nature reviews. Gastroenterology & hepatology | 25645971 | Nat Rev Gastroenterol Hepatol | 2015 Mar | https://www.ncbi.nlm.nih.gov/pubmed/25645971 |
| Generating human intestinal tissues from pluripotent stem cells to study development and disease. | Sinagoga KL, Wells JM | The EMBO journal | 25792515 | EMBO J | 2015 May 5 | https://www.ncbi.nlm.nih.gov/pubmed/25792515 |
| Building additional complexity to in vitro-derived intestinal tissues. | Brugmann SA, Wells JM | Stem cell research & therapy | 24565179 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24565179 |
| Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. | Kong J, Whelan KA, Laczkó D, Dang B, Caro Monroig A, Soroush A, Falcone J, Amaravadi RK, Rustgi AK, Ginsberg GG, Falk GW, Nakagawa H, Lynch JP | Molecular carcinogenesis | 26373456 | Mol Carcinog | 2016 Nov | https://www.ncbi.nlm.nih.gov/pubmed/26373456 |
| Mechanisms of Barrett's oesophagus: intestinal differentiation, stem cells, and tissue models. | Nakagawa H, Whelan K, Lynch JP | Best practice & research. Clinical gastroenterology | 25743452 | Best Pract Res Clin Gastroenterol | 2015 Feb | https://www.ncbi.nlm.nih.gov/pubmed/25743452 |
| A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. | Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH | American journal of physiology. Gastrointestinal and liver physiology | 23928185 | Am J Physiol Gastrointest Liver Physiol | 2013 Oct 15 | https://www.ncbi.nlm.nih.gov/pubmed/23928185 |
| Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. | Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA | Infection and immunity | 27481254 | Infect Immun | 2016 Oct | https://www.ncbi.nlm.nih.gov/pubmed/27481254 |
| Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. | Hartman KG, Bortner JD, Falk GW, Yu J, Martín MG, Rustgi AK, Lynch JP | Stem cell research & therapy | 24564965 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24564965 |
| Culturing adult stem cells from mouse small intestinal crypts. | Hamilton KE, Crissey MA, Lynch JP, Rustgi AK | Cold Spring Harbor protocols | 25834260 | Cold Spring Harb Protoc | 2015 Apr 1 | https://www.ncbi.nlm.nih.gov/pubmed/25834260 |
| Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. | Hartman KG, Bortner JD Jr, Falk GW, Ginsberg GG, Jhala N, Yu J, Martín MG, Rustgi AK, Lynch JP | Experimental biology and medicine (Maywood, N.J.) | 24781339 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24781339 |
| Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia. | Kong J, Sai H, Crissey MA, Jhala N, Falk GW, Ginsberg GG, Abrams JA, Nakagawa H, Wang K, Rustgi AK, Wang TC, Lynch JP | Oncotarget | 26460825 | Oncotarget | 2015 Oct 20 | https://www.ncbi.nlm.nih.gov/pubmed/26460825 |
| Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research. | Abrams JA, Appelman HD, Beer DG, Berry LD, Chak A, Falk GW, Fitzgerald RC, Ginsberg GG, Grady WM, Joshi BP, Lynch JP, Markowitz S, Richmond ES, Rustgi AK, Seibel EJ, Shaheen NJ, Shyr Y, Umar A, Wang KK, Wang TC, Wang TD, Yassin R | Gastroenterology | 24768332 | Gastroenterology | 2014 Jun | https://www.ncbi.nlm.nih.gov/pubmed/24768332 |
| Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. | Vega ME, Giroux V, Natsuizaka M, Liu M, Klein-Szanto AJ, Stairs DB, Nakagawa H, Wang KK, Wang TC, Lynch JP, Rustgi AK | Cell cycle (Georgetown, Tex.) | 25558829 | Cell Cycle | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/25558829 |
| Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling. | Jiang Y, Hu C, Yu S, Yan J, Peng H, Ouyang HW, Tuan RS | Arthritis research & therapy | 26577823 | Arthritis Res Ther | 2015 Nov 17 | https://www.ncbi.nlm.nih.gov/pubmed/26577823 |
| Distributed and Lumped Parameter Models for the Characterization of High Throughput Bioreactors. | Iannetti L, D'Urso G, Conoscenti G, Cutrì E, Tuan RS, Raimondi MT, Gottardi R, Zunino P | PloS one | 27669413 | PLoS One | 2016 | https://www.ncbi.nlm.nih.gov/pubmed/27669413 |
| A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads. | Capuana E, Marino D, Di Gesù R, La Carrubba V, Brucato V, Tuan RS, Gottardi R | Cells, tissues, organs | 34261061 | Cells Tissues Organs | 2022 | https://www.ncbi.nlm.nih.gov/pubmed/34261061 |
| Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. | Lozito TP, Alexander PG, Lin H, Gottardi R, Cheng AW, Tuan RS | Stem cell research & therapy | 24564995 | Stem Cell Res Ther | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24564995 |
| Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering. | Sun AX, Lin H, Beck AM, Kilroy EJ, Tuan RS | Frontiers in bioengineering and biotechnology | 26347860 | Front Bioeng Biotechnol | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26347860 |
| Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. | Alexander PG, Gottardi R, Lin H, Lozito TP, Tuan RS | Experimental biology and medicine (Maywood, N.J.) | 24994814 | Exp Biol Med (Maywood) | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24994814 |
| A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit. | Chiesa I, Di Gesù R, Overholt KJ, Gottardi R | Methods in molecular biology (Clifton, N.J.) | 34520018 | Methods Mol Biol | 2022 | https://www.ncbi.nlm.nih.gov/pubmed/34520018 |
| Regenerative medicine in 2012: the coming of age of musculoskeletal tissue engineering. | Tuan RS | Nature reviews. Rheumatology | 23321611 | Nat Rev Rheumatol | 2013 Feb | https://www.ncbi.nlm.nih.gov/pubmed/23321611 |
| Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. | Jiang Y, Cai Y, Zhang W, Yin Z, Hu C, Tong T, Lu P, Zhang S, Neculai D, Tuan RS, Ouyang HW | Stem cells translational medicine | 27130221 | Stem Cells Transl Med | 2016 Jun | https://www.ncbi.nlm.nih.gov/pubmed/27130221 |
| Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β. | Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS | Molecular pharmaceutics | 24830762 | Mol Pharm | 2014 Jul 7 | https://www.ncbi.nlm.nih.gov/pubmed/24830762 |
| Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor. | Diederichs S, Tuan RS | Stem cells and development | 24625206 | Stem Cells Dev | 2014 Jul 15 | https://www.ncbi.nlm.nih.gov/pubmed/24625206 |
| Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies. | Hofer HR, Tuan RS | Stem cell research & therapy | 27612948 | Stem Cell Res Ther | 2016 Sep 9 | https://www.ncbi.nlm.nih.gov/pubmed/27612948 |
| Origin and function of cartilage stem/progenitor cells in osteoarthritis. | Jiang Y, Tuan RS | Nature reviews. Rheumatology | 25536487 | Nat Rev Rheumatol | 2015 Apr | https://www.ncbi.nlm.nih.gov/pubmed/25536487 |
| Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix. | Yang G, Rothrauff BB, Lin H, Gottardi R, Alexander PG, Tuan RS | Biomaterials | 24044998 | Biomaterials | 2013 Dec | https://www.ncbi.nlm.nih.gov/pubmed/24044998 |
| Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution. | Lin H, Cheng AW, Alexander PG, Beck AM, Tuan RS | Tissue engineering. Part A | 24575844 | Tissue Eng Part A | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24575844 |
| Adaptive clinical trials: a partial remedy for the therapeutic misconception? | Meurer WJ, Lewis RJ, Berry DA | JAMA | 22692168 | JAMA | 2012 Jun 13 | https://www.ncbi.nlm.nih.gov/pubmed/22692168 |
| Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. | Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, Shinnar S, Conwit R, Meinzer C, Cock H, Fountain N, Connor JT, Silbergleit R, NETT and PECARN Investigators | The New England journal of medicine | 31774955 | N Engl J Med | 2019 Nov 28 | https://www.ncbi.nlm.nih.gov/pubmed/31774955 |
| Lessons from the Established Status Epilepticus Treatment Trial. | Cock HR, Coles LD, Elm J, Silbergleit R, Chamberlain JM, Cloyd JC, Fountain N, Shinnar S, Lowenstein D, Conwit R, Bleck TP, Kapur J | Epilepsy & behavior : E&B | 31653603 | Epilepsy Behav | 2019 Dec | https://www.ncbi.nlm.nih.gov/pubmed/31653603 |
| Attitudes and opinions regarding confirmatory adaptive clinical trials: a mixed methods analysis from the Adaptive Designs Accelerating Promising Trials into Treatments (ADAPT-IT) project. | Meurer WJ, Legocki L, Mawocha S, Frederiksen SM, Guetterman TC, Barsan W, Lewis R, Berry D, Fetters M | Trials | 27473126 | Trials | 2016 Jul 29 | https://www.ncbi.nlm.nih.gov/pubmed/27473126 |
| Intracerebral hemorrhage mortality is not changing despite declining incidence. | Zahuranec DB, Lisabeth LD, Sánchez BN, Smith MA, Brown DL, Garcia NM, Skolarus LE, Meurer WJ, Burke JF, Adelman EE, Morgenstern LB | Neurology | 24838789 | Neurology | 2014 Jun 17 | https://www.ncbi.nlm.nih.gov/pubmed/24838789 |
| Effect of insurance status on postacute care among working age stroke survivors. | Skolarus LE, Meurer WJ, Burke JF, Prvu Bettger J, Lisabeth LD | Neurology | 22551730 | Neurology | 2012 May 15 | https://www.ncbi.nlm.nih.gov/pubmed/22551730 |
| Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest. | Meurer WJ, Schmitzberger FF, Yeatts S, Ramakrishnan V, Abella B, Aufderheide T, Barsan W, Benoit J, Berry S, Black J, Bozeman N, Broglio K, Brown J, Brown K, Carlozzi N, Caveney A, Cho SM, Chung-Esaki H, Clevenger R, Conwit R, Cooper R, Crudo V, Daya M, Harney D, Hsu C, Johnson NJ, Khan I, Khosla S, Kline P, Kratz A, Kudenchuk P, Lewis RJ, Madiyal C, Meyer S, Mosier J, Mouammar M, Neth M, O'Neil B, Paxton J, Perez S, Perman S, Sozener C, Speers M, Spiteri A, Stevenson V, Sunthankar K, Tonna J, Youngquist S, Geocadin R, Silbergleit R, ICECAP trial investigators | Trials | 39044295 | Trials | 2024 Jul 23 | https://www.ncbi.nlm.nih.gov/pubmed/39044295 |
| Bayesian adaptive trials offer advantages in comparative effectiveness trials: an example in status epilepticus. | Connor JT, Elm JJ, Broglio KR, ESETT and ADAPT-IT Investigators | Journal of clinical epidemiology | 23849147 | J Clin Epidemiol | 2013 Aug | https://www.ncbi.nlm.nih.gov/pubmed/23849147 |
| A conceptual model for the development process of confirmatory adaptive clinical trials within an emergency research network. | Mawocha SC, Fetters MD, Legocki LJ, Guetterman TC, Frederiksen S, Barsan WG, Lewis RJ, Berry DA, Meurer WJ | Clinical trials (London, England) | 28135827 | Clin Trials | 2017 Jun | https://www.ncbi.nlm.nih.gov/pubmed/28135827 |
| Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis. | Legocki LJ, Meurer WJ, Frederiksen S, Lewis RJ, Durkalski VL, Berry DA, Barsan WG, Fetters MD | BMC medical ethics | 25933921 | BMC Med Ethics | 2015 May 3 | https://www.ncbi.nlm.nih.gov/pubmed/25933921 |
| The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study. | Connor JT, Broglio KR, Durkalski V, Meurer WJ, Johnston KC | Trials | 25885963 | Trials | 2015 Mar 4 | https://www.ncbi.nlm.nih.gov/pubmed/25885963 |
| Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. | Chamberlain JM, Kapur J, Shinnar S, Elm J, Holsti M, Babcock L, Rogers A, Barsan W, Cloyd J, Lowenstein D, Bleck TP, Conwit R, Meinzer C, Cock H, Fountain NB, Underwood E, Connor JT, Silbergleit R, Neurological Emergencies Treatment Trials, Pediatric Emergency Care Applied Research Network investigators | Lancet (London, England) | 32203691 | Lancet | 2020 Apr 11 | https://www.ncbi.nlm.nih.gov/pubmed/32203691 |
| Electroencephalographic Seizures in Emergency Department Patients After Treatment for Convulsive Status Epilepticus. | Zehtabchi S, Silbergleit R, Chamberlain JM, Shinnar S, Elm JJ, Underwood E, Rosenthal ES, Bleck TP, Kapur J | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society | 33337664 | J Clin Neurophysiol | 2022 Sep 1 | https://www.ncbi.nlm.nih.gov/pubmed/33337664 |
| The established status epilepticus trial 2013. | Bleck T, Cock H, Chamberlain J, Cloyd J, Connor J, Elm J, Fountain N, Jones E, Lowenstein D, Shinnar S, Silbergleit R, Treiman D, Trinka E, Kapur J | Epilepsia | 24001084 | Epilepsia | 2013 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24001084 |
| Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus. | Rosenthal ES, Elm JJ, Ingles J, Rogers AJ, Terndrup TE, Holsti M, Thomas DG, Babcock L, Okada PJ, Lipsky RH, Miller JB, Hickey RW, Barra ME, Bleck TP, Cloyd JC, Silbergleit R, Lowenstein DH, Coles LD, Kapur J, Shinnar S, Chamberlain JM, Established Status Epilepticus Treatment Trial Study Group | Neurology | 34032604 | Neurology | 2021 May 11 | https://www.ncbi.nlm.nih.gov/pubmed/34032604 |
| Reflections on the Adaptive Designs Accelerating Promising Trials Into Treatments (ADAPT-IT) Process-Findings from a Qualitative Study. | Guetterman TC, Fetters MD, Legocki LJ, Mawocha S, Barsan WG, Lewis RJ, Berry DA, Meurer WJ | Clinical research and regulatory affairs | 26622163 | Clin Res Regul Aff | 2015 Oct 2 | https://www.ncbi.nlm.nih.gov/pubmed/26622163 |
| Comparison of Bayesian vs Frequentist Adaptive Trial Design in the Stroke Hyperglycemia Insulin Network Effort Trial. | Broglio K, Meurer WJ, Durkalski V, Pauls Q, Connor J, Berry D, Lewis RJ, Johnston KC, Barsan WG | JAMA network open | 35544137 | JAMA Netw Open | 2022 May 2 | https://www.ncbi.nlm.nih.gov/pubmed/35544137 |
| Spinal cord injury neuroprotection and the promise of flexible adaptive clinical trials. | Meurer WJ, Barsan WG | World neurosurgery | 23851207 | World Neurosurg | 2014 Sep-Oct | https://www.ncbi.nlm.nih.gov/pubmed/23851207 |
| Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design. | Johnston SC, Easton JD, Farrant M, Barsan W, Battenhouse H, Conwit R, Dillon C, Elm J, Lindblad A, Morgenstern L, Poisson SN, Palesch Y | International journal of stroke : official journal of the International Stroke Society | 23879752 | Int J Stroke | 2013 Aug | https://www.ncbi.nlm.nih.gov/pubmed/23879752 |
| An overview of the adaptive designs accelerating promising trials into treatments (ADAPT-IT) project. | Meurer WJ, Lewis RJ, Tagle D, Fetters MD, Legocki L, Berry S, Connor J, Durkalski V, Elm J, Zhao W, Frederiksen S, Silbergleit R, Palesch Y, Berry DA, Barsan WG | Annals of emergency medicine | 22424650 | Ann Emerg Med | 2012 Oct | https://www.ncbi.nlm.nih.gov/pubmed/22424650 |
| Muscle on a chip: in vitro contractility assays for smooth and striated muscle. | Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK | Journal of pharmacological and toxicological methods | 22521339 | J Pharmacol Toxicol Methods | 2012 May-Jun | https://www.ncbi.nlm.nih.gov/pubmed/22521339 |
| Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip. | Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK | Advanced functional materials | 26213529 | Adv Funct Mater | 2013 Aug 12 | https://www.ncbi.nlm.nih.gov/pubmed/26213529 |
| Microfluidic heart on a chip for higher throughput pharmacological studies. | Agarwal A, Goss JA, Cho A, McCain ML, Parker KK | Lab on a chip | 23807141 | Lab Chip | 2013 Sep 21 | https://www.ncbi.nlm.nih.gov/pubmed/23807141 |
| Clear castable polyurethane elastomer for fabrication of microfluidic devices. | Domansky K, Leslie DC, McKinney J, Fraser JP, Sliz JD, Hamkins-Indik T, Hamilton GA, Bahinski A, Ingber DE | Lab on a chip | 23954953 | Lab Chip | 2013 Oct 7 | https://www.ncbi.nlm.nih.gov/pubmed/23954953 |
| Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. | Grosberg A, Alford PW, McCain ML, Parker KK | Lab on a chip | 22072288 | Lab Chip | 2011 Dec 21 | https://www.ncbi.nlm.nih.gov/pubmed/22072288 |
| The contribution of cellular mechanotransduction to cardiomyocyte form and function. | Sheehy SP, Grosberg A, Parker KK | Biomechanics and modeling in mechanobiology | 22772714 | Biomech Model Mechanobiol | 2012 Nov | https://www.ncbi.nlm.nih.gov/pubmed/22772714 |
| Microfabrication of human organs-on-chips. | Huh D, Kim HJ, Fraser JP, Shea DE, Khan M, Bahinski A, Hamilton GA, Ingber DE | Nature protocols | 24113786 | Nat Protoc | 2013 Nov | https://www.ncbi.nlm.nih.gov/pubmed/24113786 |
| A mini-microscope for in situ monitoring of cells. | Kim SB, Koo KI, Bae H, Dokmeci MR, Hamilton GA, Bahinski A, Kim SM, Ingber DE, Khademhosseini A | Lab on a chip | 22911426 | Lab Chip | 2012 Oct 21 | https://www.ncbi.nlm.nih.gov/pubmed/22911426 |
| A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. | Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander MA, Ingber DE | Science translational medicine | 23136042 | Sci Transl Med | 2012 Nov 7 | https://www.ncbi.nlm.nih.gov/pubmed/23136042 |
| Standardizing data. | Baker NA, Klemm JD, Harper SL, Gaheen S, Heiskanen M, Rocca-Serra P, Sansone SA | Nature nanotechnology | 23380926 | Nat Nanotechnol | 2013 Feb | https://www.ncbi.nlm.nih.gov/pubmed/23380926 |
| Antiangiogenic nanotherapy with lipase-labile Sn-2 fumagillin prodrug. | Pan D, Sanyal N, Schmieder AH, Senpan A, Kim B, Yang X, Hu G, Allen JS, Gross RW, Wickline SA, Lanza GM | Nanomedicine (London, England) | 22709347 | Nanomedicine (Lond) | 2012 Oct | https://www.ncbi.nlm.nih.gov/pubmed/22709347 |
| Simulation of fusion-mediated nanoemulsion interactions with model lipid bilayers. | Lee SJ, Schlesinger PH, Wickline SA, Lanza GM, Baker NA | Soft matter | 22712024 | Soft Matter | 2012 Jan 1 | https://www.ncbi.nlm.nih.gov/pubmed/22712024 |
| Nanotherapeutic approaches for the treatment of rheumatoid arthritis. | Pham CT | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | 21837725 | Wiley Interdiscip Rev Nanomed Nanobiotechnol | 2011 Nov-Dec | https://www.ncbi.nlm.nih.gov/pubmed/21837725 |
| Informatics and standards for nanomedicine technology. | Thomas DG, Klaessig F, Harper SL, Fritts M, Hoover MD, Gaheen S, Stokes TH, Reznik-Zellen R, Freund ET, Klemm JD, Paik DS, Baker NA | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | 21721140 | Wiley Interdiscip Rev Nanomed Nanobiotechnol | 2011 Sep-Oct | https://www.ncbi.nlm.nih.gov/pubmed/21721140 |
| Manganese-based MRI contrast agents: past, present and future. | Pan D, Schmieder AH, Wickline SA, Lanza GM | Tetrahedron | 22043109 | Tetrahedron | 2011 Nov 4 | https://www.ncbi.nlm.nih.gov/pubmed/22043109 |
| Antagonizing the αv β3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading. | Tomlinson RE, Schmieder AH, Quirk JD, Lanza GM, Silva MJ | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 24644077 | J Bone Miner Res | 2014 Sep | https://www.ncbi.nlm.nih.gov/pubmed/24644077 |
| Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles. | Zhou HF, Yan H, Senpan A, Wickline SA, Pan D, Lanza GM, Pham CT | Biomaterials | 22922023 | Biomaterials | 2012 Nov | https://www.ncbi.nlm.nih.gov/pubmed/22922023 |
| Molecular imaging with computed tomography. | Lanza GM, Pan D | Contrast media & molecular imaging | 24470289 | Contrast Media Mol Imaging | 2014 Jan-Feb | https://www.ncbi.nlm.nih.gov/pubmed/24470289 |
| Multicolor computed tomographic molecular imaging with noncrystalline high-metal-density nanobeacons. | Pan D, Schirra CO, Wickline SA, Lanza GM | Contrast media & molecular imaging | 24470291 | Contrast Media Mol Imaging | 2014 Jan-Feb | https://www.ncbi.nlm.nih.gov/pubmed/24470291 |
| Balanced UTE-SSFP for 19F MR imaging of complex spectra. | Goette MJ, Keupp J, Rahmer J, Lanza GM, Wickline SA, Caruthers SD | Magnetic resonance in medicine | 25163853 | Magn Reson Med | 2015 Aug | https://www.ncbi.nlm.nih.gov/pubmed/25163853 |
| Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers. | Daily MD, Olsen BN, Schlesinger PH, Ory DS, Baker NA | Journal of chemical theory and computation | 24910542 | J Chem Theory Comput | 2014 May 13 | https://www.ncbi.nlm.nih.gov/pubmed/24910542 |
| MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation. | Bulte JW, Schmieder AH, Keupp J, Caruthers SD, Wickline SA, Lanza GM | Nanomedicine : nanotechnology, biology, and medicine | 24832959 | Nanomedicine | 2014 Oct | https://www.ncbi.nlm.nih.gov/pubmed/24832959 |
| Interaction of melittin peptides with perfluorocarbon nanoemulsion particles. | Lee SJ, Schlesinger PH, Wickline SA, Lanza GM, Baker NA | The journal of physical chemistry. B | 22050303 | J Phys Chem B | 2011 Dec 29 | https://www.ncbi.nlm.nih.gov/pubmed/22050303 |
| Assessing the barriers to image-guided drug delivery. | Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, Zheng G, Farahani K | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | 24339356 | Wiley Interdiscip Rev Nanomed Nanobiotechnol | 2014 Jan-Feb | https://www.ncbi.nlm.nih.gov/pubmed/24339356 |
| Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using α(v)β₃-targeted theranostic nanoparticles. | Pan D, Schmieder AH, Wang K, Yang X, Senpan A, Cui G, Killgore K, Kim B, Allen JS, Zhang H, Caruthers SD, Shen B, Wickline SA, Lanza GM | Theranostics | 24723979 | Theranostics | 2014 | https://www.ncbi.nlm.nih.gov/pubmed/24723979 |
| Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces. | Pham CT, Mitchell LM, Huang JL, Lubniewski CM, Schall OF, Killgore JK, Pan D, Wickline SA, Lanza GM, Hourcade DE | The Journal of biological chemistry | 21047788 | J Biol Chem | 2011 Jan 7 | https://www.ncbi.nlm.nih.gov/pubmed/21047788 |
| Characterization of early neovascular response to acute lung ischemia using simultaneous (19)F/ (1)H MR molecular imaging. | Schmieder AH, Wang K, Zhang H, Senpan A, Pan D, Keupp J, Caruthers SD, Wickline SA, Shen B, Wagner EM, Lanza GM | Angiogenesis | 23918207 | Angiogenesis | 2014 Jan | https://www.ncbi.nlm.nih.gov/pubmed/23918207 |
| Rapid quantification of oxygen tension in blood flow with a fluorine nanoparticle reporter and a novel blood flow-enhanced-saturation-recovery sequence. | Hu L, Chen J, Yang X, Caruthers SD, Lanza GM, Wickline SA | Magnetic resonance in medicine | 22915328 | Magn Reson Med | 2013 Jul | https://www.ncbi.nlm.nih.gov/pubmed/22915328 |
| ISA-TAB-Nano: a specification for sharing nanomaterial research data in spreadsheet-based format. | Thomas DG, Gaheen S, Harper SL, Fritts M, Klaessig F, Hahn-Dantona E, Paik D, Pan S, Stafford GA, Freund ET, Klemm JD, Baker NA | BMC biotechnology | 23311978 | BMC Biotechnol | 2013 Jan 14 | https://www.ncbi.nlm.nih.gov/pubmed/23311978 |
| Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide. | Zhou HF, Yan H, Hu Y, Springer LE, Yang X, Wickline SA, Pan D, Lanza GM, Pham CT | ACS nano | 24941020 | ACS Nano | 2014 Jul 22 | https://www.ncbi.nlm.nih.gov/pubmed/24941020 |
| Near infrared imaging of EGFR of oral squamous cell carcinoma in mice administered arsenic trioxide. | Zhang L, Wang K, Zhao F, Hu W, Chen J, Lanza GM, Shen B, Zhang B | PloS one | 23029451 | PLoS One | 2012 | https://www.ncbi.nlm.nih.gov/pubmed/23029451 |
| ICAM-1 and nanomedicine: nature's doorway to the extravascular tissue realm. | Lanza GM | Arteriosclerosis, thrombosis, and vascular biology | 22517363 | Arterioscler Thromb Vasc Biol | 2012 May | https://www.ncbi.nlm.nih.gov/pubmed/22517363 |
| A brief account of nanoparticle contrast agents for photoacoustic imaging. | Pan D, Kim B, Wang LV, Lanza GM | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology | 23983210 | Wiley Interdiscip Rev Nanomed Nanobiotechnol | 2013 Nov-Dec | https://www.ncbi.nlm.nih.gov/pubmed/23983210 |
| Angiogenesis is required for stress fracture healing in rats. | Tomlinson RE, McKenzie JA, Schmieder AH, Wohl GR, Lanza GM, Silva MJ | Bone | 23044046 | Bone | 2013 Jan | https://www.ncbi.nlm.nih.gov/pubmed/23044046 |
| Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity. | Harper B, Thomas D, Chikkagoudar S, Baker N, Tang K, Heredia-Langner A, Lins R, Harper S | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology | 26069453 | J Nanopart Res | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/26069453 |
| A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. | Pan D, Kim B, Hu G, Gupta DS, Senpan A, Yang X, Schmieder A, Swain C, Wickline SA, Tomasson MH, Lanza GM | Nanomedicine (London, England) | 25600969 | Nanomedicine (Lond) | 2015 Jan | https://www.ncbi.nlm.nih.gov/pubmed/25600969 |
| Application of a hemolysis assay for analysis of complement activation by perfluorocarbon nanoparticles. | Pham CT, Thomas DG, Beiser J, Mitchell LM, Huang JL, Senpan A, Hu G, Gordon M, Baker NA, Pan D, Lanza GM, Hourcade DE | Nanomedicine : nanotechnology, biology, and medicine | 24211337 | Nanomedicine | 2014 Apr | https://www.ncbi.nlm.nih.gov/pubmed/24211337 |
| Angiogenesis and airway reactivity in asthmatic Brown Norway rats. | Wagner EM, Jenkins J, Schmieder A, Eldridge L, Zhang Q, Moldobaeva A, Zhang H, Allen JS, Yang X, Mitzner W, Keupp J, Caruthers SD, Wickline SA, Lanza GM | Angiogenesis | 25149641 | Angiogenesis | 2015 Jan | https://www.ncbi.nlm.nih.gov/pubmed/25149641 |
| Nanoinformatics workshop report: Current resources, community needs, and the proposal of a collaborative framework for data sharing and information integration. | Harper SL, Hutchison JE, Baker N, Ostraat M, Tinkle S, Steevens J, Hoover MD, Adamick J, Rajan K, Gaheen S, Cohen Y, Nel A, Cachau RE, Tuominen M | Computational science & discovery | 24454543 | Comput Sci Discov | 2013 | https://www.ncbi.nlm.nih.gov/pubmed/24454543 |
| Nanoinformatics: developing new computing applications for nanomedicine. | Maojo V, Fritts M, Martin-Sanchez F, De la Iglesia D, Cachau RE, Garcia-Remesal M, Crespo J, Mitchell JA, Anguita A, Baker N, Barreiro JM, Benitez SE, De la Calle G, Facelli JC, Ghazal P, Geissbuhler A, Gonzalez-Nilo F, Graf N, Grangeat P, Hermosilla I, Hussein R, Kern J, Koch S, Legre Y, Lopez-Alonso V, Lopez-Campos G, Milanesi L, Moustakis V, Munteanu C, Otero P, Pazos A, Perez-Rey D, Potamias G, Sanz F, Kulikowski C | Computing in science & engineering | 22942787 | Comput Sci Eng | 2012 Jun 1 | https://www.ncbi.nlm.nih.gov/pubmed/22942787 |
| Second Generation Gold Nanobeacons for Robust K-Edge Imaging with Multi-Energy CT. | Schirra CO, Senpan A, Roessl E, Thran A, Stacy AJ, Wu L, Proska R, Pan D | Journal of materials chemistry | 23185109 | J Mater Chem | 2012 Jan 1 | https://www.ncbi.nlm.nih.gov/pubmed/23185109 |
| Annotating the structure and components of a nanoparticle formulation using computable string expressions. | Thomas DG, Chikkagoudar S, Chappell AR, Baker NA | Proceedings. IEEE International Conference on Bioinformatics and Biomedicine | 24533226 | Proceedings (IEEE Int Conf Bioinformatics Biomed) | 2012 Dec 31 | https://www.ncbi.nlm.nih.gov/pubmed/24533226 |
| alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. | Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV | Theranostics | 25553103 | Theranostics | 2015 | https://www.ncbi.nlm.nih.gov/pubmed/25553103 |
| An early investigation of ytterbium nanocolloids for selective and quantitative "multicolor" spectral CT imaging. | Pan D, Schirra CO, Senpan A, Schmieder AH, Stacy AJ, Roessl E, Thran A, Wickline SA, Proska R, Lanza GM | ACS nano | 22385324 | ACS Nano | 2012 Apr 24 | https://www.ncbi.nlm.nih.gov/pubmed/22385324 |
| Physicochemical signatures of nanoparticle-dependent complement activation. | Thomas DG, Chikkagoudar S, Heredia-Langer A, Tardiff MF, Xu Z, Hourcade DE, Pham CT, Lanza GM, Weinberger KQ, Baker NA | Computational science & discovery | 25254068 | Comput Sci Discov | 2014 Mar 21 | https://www.ncbi.nlm.nih.gov/pubmed/25254068 |
| Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers. | Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM | Nanomedicine : nanotechnology, biology, and medicine | 25652900 | Nanomedicine | 2015 Apr | https://www.ncbi.nlm.nih.gov/pubmed/25652900 |
