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The search results on this publication page are automated on a monthly schedule based on acknowledgement of NIH Common Fund award numbers and intramural awards. Therefore, this list is not an exhaustive or error-free account of the program’s publications.

Title Author Journal Name PubMedID Journal Abbreviation Publication Date
Human fallopian tube epithelium co-culture with murine ovarian follicles reveals crosstalk in the reproductive cycle. Zhu J, Xu Y, Rashedi AS, Pavone ME, Kim JJ, Woodruff TK, Burdette JE Molecular human reproduction 27542947 Mol Hum Reprod 2016 Nov
Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface. Karthikeyan S, Lantvit DD, Chae DH, Burdette JE Oncotarget 27563818 Oncotarget 2016 Oct 25
Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids. Edmonds ME, Forshee MD, Woodruff TK Journal of visualized experiments : JoVE 33104061 J Vis Exp 2020 Oct 7
A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control. Coppeta JR, Mescher MJ, Isenberg BC, Spencer AJ, Kim ES, Lever AR, Mulhern TJ, Prantil-Baun R, Comolli JC, Borenstein JT Lab on a chip 27901159 Lab Chip 2016 Dec 20
A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells. Stranford DM, Hung ME, Gargus ES, Shah RN, Leonard JN Tissue engineering. Part A 28586292 Tissue Eng Part A 2017 Nov
Engineering the ovarian cycle using in vitro follicle culture. Skory RM, Xu Y, Shea LD, Woodruff TK Human reproduction (Oxford, England) 25784584 Hum Reprod 2015 Jun
Three-dimensional modeling of the human fallopian tube fimbriae. Eddie SL, Quartuccio SM, Zhu J, Shepherd JA, Kothari R, Kim JJ, Woodruff TK, Burdette JE Gynecologic oncology 25527363 Gynecol Oncol 2015 Feb
Testicular organoid formation is a property of immature somatic cells, which self-assemble and exhibit long-term hormone-responsive endocrine function. Edmonds ME, Woodruff TK Biofabrication 32492667 Biofabrication 2020 Jul 9
A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN Nature communications 28509899 Nat Commun 2017 May 16
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators. Moyle-Heyrman G, Schipma MJ, Dean M, Davis DA, Burdette JE Journal of ovarian research 26879975 J Ovarian Res 2016 Feb 15
Good manufacturing practice requirements for the production of tissue vitrification and warming and recovery kits for clinical research. Laronda MM, McKinnon KE, Ting AY, Le Fever AV, Zelinski MB, Woodruff TK Journal of assisted reproduction and genetics 27900615 J Assist Reprod Genet 2017 Feb
Engineered reproductive tissues. Gargus ES, Rogers HB, McKinnon KE, Edmonds ME, Woodruff TK Nature biomedical engineering 32251392 Nat Biomed Eng 2020 Apr
Multidrug Resistance Protein 1 Deficiency Promotes Doxorubicin-Induced Ovarian Toxicity in Female Mice. Wang Y, Liu M, Zhang J, Liu Y, Kopp M, Zheng W, Xiao S Toxicological sciences : an official journal of the Society of Toxicology 29462422 Toxicol Sci 2018 May 1
Microphysiologic systems in female reproductive biology. Young AN, Moyle-Heyrman G, Kim JJ, Burdette JE Experimental biology and medicine (Maywood, N.J.) 29065798 Exp Biol Med (Maywood) 2017 Nov
Doxorubicin Has Dose-Dependent Toxicity on Mouse Ovarian Follicle Development, Hormone Secretion, and Oocyte Maturation. Xiao S, Zhang J, Liu M, Iwahata H, Rogers HB, Woodruff TK Toxicological sciences : an official journal of the Society of Toxicology 28329872 Toxicol Sci 2017 Jun 1
Initiation of puberty in mice following decellularized ovary transplant. Laronda MM, Jakus AE, Whelan KA, Wertheim JA, Shah RN, Woodruff TK Biomaterials 25736492 Biomaterials 2015 May
Distinct follicular and luteal transcriptional profiles in engineered human ectocervical tissue dependent on menstrual cycle phase. McKinnon KE, Getsios S, Woodruff TK Biology of reproduction 32614039 Biol Reprod 2020 Aug 21
Novel three dimensional human endocervix cultures respond to 28-day hormone treatment. Arslan SY, Yu Y, Burdette JE, Pavone ME, Hope TJ, Woodruff TK, Kim JJ Endocrinology 25635622 Endocrinology 2015 Apr
Use of an organotypic mammalian in vitro follicle growth assay to facilitate female reproductive toxicity screening. Xu Y, Duncan FE, Xu M, Woodruff TK Reproduction, fertility, and development 25689754 Reprod Fertil Dev 2015 Feb 18
Endometriosis and ovarian cancer: links, risks, and challenges faced. Pavone ME, Lyttle BM International journal of women's health 26170722 Int J Womens Health 2015
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK Nature communications 28350383 Nat Commun 2017 Mar 28
Approaching the in vitro clinical trial: engineering organs on chips. Capulli AK, Tian K, Mehandru N, Bukhta A, Choudhury SF, Suchyta M, Parker KK Lab on a chip 24828385 Lab Chip 2014 Sep 7
Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Nesmith AP, Agarwal A, McCain ML, Parker KK Lab on a chip 25093641 Lab Chip 2014 Oct 21
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Lind JU, Busbee TA, Valentine AD, Pasqualini FS, Yuan H, Yadid M, Park SJ, Kotikian A, Nesmith AP, Campbell PH, Vlassak JJ, Lewis JA, Parker KK Nature materials 27775708 Nat Mater 2017 Mar
Mechanotransduction and Metabolism in Cardiomyocyte Microdomains. Pasqualini FS, Nesmith AP, Horton RE, Sheehy SP, Parker KK BioMed research international 28044126 Biomed Res Int 2016
Traction force microscopy of engineered cardiac tissues. Pasqualini FS, Agarwal A, O'Connor BB, Liu Q, Sheehy SP, Parker KK PloS one 29590169 PLoS One 2018
Angiotensin II Induced Cardiac Dysfunction on a Chip. Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK PloS one 26808388 PLoS One 2016
Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue. Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK Circulation 31311300 Circulation 2019 Jul 30
Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK Biomaterials 24731714 Biomaterials 2014 Jul
Three-dimensional paper-based model for cardiac ischemia. Mosadegh B, Dabiri BE, Lockett MR, Derda R, Campbell P, Parker KK, Whitesides GM Advanced healthcare materials 24574054 Adv Healthc Mater 2014 Jul
The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function. Ye GJ, Nesmith AP, Parker KK Anatomical record (Hoboken, N.J. : 2007) 25125187 Anat Rec (Hoboken) 2014 Sep
Phototactic guidance of a tissue-engineered soft-robotic ray. Park SJ, Gazzola M, Park KS, Park S, Di Santo V, Blevins EL, Lind JU, Campbell PH, Dauth S, Capulli AK, Pasqualini FS, Ahn S, Cho A, Yuan H, Maoz BM, Vijaykumar R, Choi JW, Deisseroth K, Lauder GV, Mahadevan L, Parker KK Science (New York, N.Y.) 27387948 Science 2016 Jul 8
Organ Chips: Quality Assurance Systems in Regenerative Medicine. Pasqualini FS, Emmert MY, Parker KK, Hoerstrup SP Clinical pharmacology and therapeutics 27709615 Clin Pharmacol Ther 2017 Jan
Fibrous scaffolds for building hearts and heart parts. Capulli AK, MacQueen LA, Sheehy SP, Parker KK Advanced drug delivery reviews 26656602 Adv Drug Deliv Rev 2016 Jan 15
Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. Malladi S, Miranda-Nieves D, Leng L, Grainger SJ, Tarabanis C, Nesmith AP, Kosaraju R, Haller CA, Parker KK, Chaikof EL, Günther A ACS biomaterials science & engineering 32685675 ACS Biomater Sci Eng 2020 Jul 13
An autonomously swimming biohybrid fish designed with human cardiac biophysics. Lee KY, Park SJ, Matthews DG, Kim SL, Marquez CA, Zimmerman JF, Ardoña HAM, Kleber AG, Lauder GV, Parker KK Science (New York, N.Y.) 35143298 Science 2022 Feb 11
Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions. Yuan H, Marzban B, Kit Parker K Journal of biomechanical engineering 28857113 J Biomech Eng 2017 Dec 1
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence. Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen L, Bezzerides VJ, Parker KK, Melton DA, Lee RT Circulation 31707831 Circulation 2020 Jan 28
Acute pergolide exposure stiffens engineered valve interstitial cell tissues and reduces contractility in vitro. Capulli AK, MacQueen LA, O'Connor BB, Dauth S, Parker KK Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 27174867 Cardiovasc Pathol 2016 Jul-Aug
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK Proceedings of the National Academy of Sciences of the United States of America 23716679 Proc Natl Acad Sci U S A 2013 Jun 11
Quality metrics for stem cell-derived cardiac myocytes. Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK Stem cell reports 24672752 Stem Cell Reports 2014 Mar 11
Structural phenotyping of stem cell-derived cardiomyocytes. Pasqualini FS, Sheehy SP, Agarwal A, Aratyn-Schaus Y, Parker KK Stem cell reports 25733020 Stem Cell Reports 2015 Mar 10
A tissue-engineered scale model of the heart ventricle. MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK Nature biomedical engineering 31015723 Nat Biomed Eng 2018 Dec
Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip. Yadid M, Lind JU, Ardoña HAM, Sheehy SP, Dickinson LE, Eweje F, Bastings MMC, Pope B, O'Connor BB, Straubhaar JR, Budnik B, Kleber AG, Parker KK Science translational medicine 33055246 Sci Transl Med 2020 Oct 14
Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening. Lind JU, Yadid M, Perkins I, O'Connor BB, Eweje F, Chantre CO, Hemphill MA, Yuan H, Campbell PH, Vlassak JJ, Parker KK Lab on a chip 28976521 Lab Chip 2017 Oct 25
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications. Nawroth JC, Scudder LL, Halvorson RT, Tresback J, Ferrier JP, Sheehy SP, Cho A, Kannan S, Sunyovszki I, Goss JA, Campbell PH, Parker KK Biofabrication 29337695 Biofabrication 2018 Jan 16
JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement. Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP, Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK Biomaterials 28445803 Biomaterials 2017 Jul
Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK American journal of physiology. Heart and circulatory physiology 24682394 Am J Physiol Heart Circ Physiol 2014 Jun 1
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT Nature medicine 24813252 Nat Med 2014 Jun
Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK The Journal of cell biology 26858266 J Cell Biol 2016 Feb 15
Recreating the heart's helical structure-function relationship with focused rotary jet spinning. Chang H, Liu Q, Zimmerman JF, Lee KY, Jin Q, Peters MM, Rosnach M, Choi S, Kim SL, Ardoña HAM, MacQueen LA, Chantre CO, Motta SE, Cordoves EM, Parker KK Science (New York, N.Y.) 35857545 Science 2022 Jul 8
Customizable biomaterials as tools for advanced anti-angiogenic drug discovery. Nguyen EH, Murphy WL Biomaterials 30077137 Biomaterials 2018 Oct
Interspecies chimeric conditions affect the developmental rate of human pluripotent stem cells. Brown J, Barry C, Schmitz MT, Argus C, Bolin JM, Schwartz MP, Van Aartsen A, Steill J, Swanson S, Stewart R, Thomson JA, Kendziorski C PLoS computational biology 33647016 PLoS Comput Biol 2021 Mar
Network inference with Granger causality ensembles on single-cell transcriptomics. Deshpande A, Chu LF, Stewart R, Gitter A Cell reports 35139376 Cell Rep 2022 Feb 8
Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and nontumorigenic human mesenchymal cell types. Hansen TD, Koepsel JT, Le NN, Nguyen EH, Zorn S, Parlato M, Loveland SG, Schwartz MP, Murphy WL Biomaterials science 25386339 Biomater Sci 2014 May
Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays. Nguyen EH, Zanotelli MR, Schwartz MP, Murphy WL Biomaterials 24332391 Biomaterials 2014 Feb
TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes. Jiang P, Chamberlain CS, Vanderby R, Thomson JA, Stewart R Nucleic acids research 32123905 Nucleic Acids Res 2020 May 21
Machine learning to predict developmental neurotoxicity with high-throughput data from 2D bio-engineered tissues. Kuusisto F, Costa VS, Hou Z, Thomson J, Page D, Stewart R Proceedings of the ... International Conference on Machine Learning and Applications. International Conference on Machine Learning and Applications 32181450 Proc Int Conf Mach Learn Appl 2019 Dec
Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels. Kaushik G, Gil DA, Torr E, Berge ES, Soref C, Uhl P, Fontana G, Antosiewicz-Bourget J, Edington C, Schwartz MP, Griffith LG, Thomson JA, Skala MC, Daly WT, Murphy WL Advanced healthcare materials 30565891 Adv Healthc Mater 2019 Jan
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Hou Z, Zhang Y, Propson NE, Howden SE, Chu LF, Sontheimer EJ, Thomson JA Proceedings of the National Academy of Sciences of the United States of America 23940360 Proc Natl Acad Sci U S A 2013 Sep 24
Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin. Pellett S, Schwartz MP, Tepp WH, Josephson R, Scherf JM, Pier CL, Thomson JA, Murphy WL, Johnson EA Scientific reports 26411797 Sci Rep 2015 Sep 28
Hydrogel arrays formed via differential wettability patterning enable combinatorial screening of stem cell behavior. Le NNT, Zorn S, Schmitt SK, Gopalan P, Murphy WL Acta biomaterialia 26386315 Acta Biomater 2016 Apr 1
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. Schwartz MP, Hou Z, Propson NE, Zhang J, Engstrom CJ, Santos Costa V, Jiang P, Nguyen BK, Bolin JM, Daly W, Wang Y, Stewart R, Page CD, Murphy WL, Thomson JA Proceedings of the National Academy of Sciences of the United States of America 26392547 Proc Natl Acad Sci U S A 2015 Oct 6
Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments. Leng N, Chu LF, Barry C, Li Y, Choi J, Li X, Jiang P, Stewart RM, Thomson JA, Kendziorski C Nature methods 26301841 Nat Methods 2015 Oct
OEFinder: a user interface to identify and visualize ordering effects in single-cell RNA-seq data. Leng N, Choi J, Chu LF, Thomson JA, Kendziorski C, Stewart R Bioinformatics (Oxford, England) 26743507 Bioinformatics 2016 May 1
Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling. Mina SG, Alaybeyoglu B, Murphy WL, Thomson JA, Stokes CL, Cirit M Frontiers in big data 33693346 Front Big Data 2019
Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL Acta biomaterialia 26945632 Acta Biomater 2016 Apr 15
A human pluripotent stem cell platform for assessing developmental neural toxicity screening. Hou Z, Zhang J, Schwartz MP, Stewart R, Page CD, Murphy WL, Thomson JA Stem cell research & therapy 24565336 Stem Cell Res Ther 2013
A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia. Zhang J, McIntosh BE, Wang B, Brown ME, Probasco MD, Webster S, Duffin B, Zhou Y, Guo LW, Burlingham WJ, Kent C, Ferris M, Thomson JA Stem cell reports 31080110 Stem Cell Reports 2019 Jun 11
Trendy: segmented regression analysis of expression dynamics in high-throughput ordered profiling experiments. Bacher R, Leng N, Chu LF, Ni Z, Thomson JA, Kendziorski C, Stewart R BMC bioinformatics 30326833 BMC Bioinformatics 2018 Oct 16
Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications. Adamski M, Fontana G, Gershlak JR, Gaudette GR, Le HD, Murphy WL Journal of visualized experiments : JoVE 29912197 J Vis Exp 2018 May 31
Functional characterization of human pluripotent stem cell-derived arterial endothelial cells. Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S, Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, Burlingham WJ, Murphy WL, Thomson JA Proceedings of the National Academy of Sciences of the United States of America 28696312 Proc Natl Acad Sci U S A 2017 Jul 25
A Genome-wide Analysis of Human Pluripotent Stem Cell-Derived Endothelial Cells in 2D or 3D Culture. Zhang J, Schwartz MP, Hou Z, Bai Y, Ardalani H, Swanson S, Steill J, Ruotti V, Elwell A, Nguyen BK, Bolin J, Stewart R, Thomson JA, Murphy WL Stem cell reports 28343999 Stem Cell Reports 2017 Apr 11
Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques. Barry C, Schmitz MT, Propson NE, Hou Z, Zhang J, Nguyen BK, Bolin JM, Jiang P, McIntosh BE, Probasco MD, Swanson S, Stewart R, Thomson JA, Schwartz MP, Murphy WL Experimental biology and medicine (Maywood, N.J.) 28599598 Exp Biol Med (Maywood) 2017 Nov
Species-specific developmental timing is maintained by pluripotent stem cells ex utero. Barry C, Schmitz MT, Jiang P, Schwartz MP, Duffin BM, Swanson S, Bacher R, Bolin JM, Elwell AL, McIntosh BE, Stewart R, Thomson JA Developmental biology 28179190 Dev Biol 2017 Mar 15
Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP, Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB, Sheibani N, Murphy WL Nature biomedical engineering 29104816 Nat Biomed Eng 2017
An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells. Chu LF, Mamott D, Ni Z, Bacher R, Liu C, Swanson S, Kendziorski C, Stewart R, Thomson JA Cell reports 31461642 Cell Rep 2019 Aug 27
Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics. Barry C, Schmitz MT, Argus C, Bolin JM, Probasco MD, Leng N, Duffin BM, Steill J, Swanson S, McIntosh BE, Stewart R, Kendziorski C, Thomson JA, Bacher R PLoS computational biology 31815944 PLoS Comput Biol 2019 Dec
Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL Stem cell reviews and reports 25190668 Stem Cell Rev Rep 2015 Jun
Biofunctionalized Plants as Diverse Biomaterials for Human Cell Culture. Fontana G, Gershlak J, Adamski M, Lee JS, Matsumoto S, Le HD, Binder B, Wirth J, Gaudette G, Murphy WL Advanced healthcare materials 28319334 Adv Healthc Mater 2017 Apr
A cost-effective RNA sequencing protocol for large-scale gene expression studies. Hou Z, Jiang P, Swanson SA, Elwell AL, Nguyen BK, Bolin JM, Stewart R, Thomson JA Scientific reports 25831155 Sci Rep 2015 Apr 1
RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. Jiang P, Hou Z, Bolin JM, Thomson JA, Stewart R Toxicological sciences : an official journal of the Society of Toxicology 28903495 Toxicol Sci 2017 Sep 1
Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm. Chu LF, Leng N, Zhang J, Hou Z, Mamott D, Vereide DT, Choi J, Kendziorski C, Stewart R, Thomson JA Genome biology 27534536 Genome Biol 2016 Aug 17
A statistical approach for identifying differential distributions in single-cell RNA-seq experiments. Korthauer KD, Chu LF, Newton MA, Li Y, Thomson J, Stewart R, Kendziorski C Genome biology 27782827 Genome Biol 2016 Oct 25
Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels. Jung Y, Ji H, Chen Z, Fai Chan H, Atchison L, Klitzman B, Truskey G, Leong KW Scientific reports 26456074 Sci Rep 2015 Oct 12
Application of induced pluripotent stem cells to model smooth muscle cell function in vascular diseases. Ji H, Kim HS, Kim HW, Leong KW Current opinion in biomedical engineering 29082353 Curr Opin Biomed Eng 2017 Mar
Biological and engineering design considerations for vascular tissue engineered blood vessels (TEBVs). Fernandez CE, Achneck HE, Reichert WM, Truskey GA Current opinion in chemical engineering 24511460 Curr Opin Chem Eng 2014 Feb 1
Physiology and metabolism of tissue-engineered skeletal muscle. Cheng CS, Davis BN, Madden L, Bursac N, Truskey GA Experimental biology and medicine (Maywood, N.J.) 24912506 Exp Biol Med (Maywood) 2014 Sep
Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. Kabadi AM, Thakore PI, Vockley CM, Ousterout DG, Gibson TM, Guilak F, Reddy TE, Gersbach CA ACS synthetic biology 25494287 ACS Synth Biol 2015 Jun 19
Human Vascular Microphysiological System for in vitro Drug Screening. Fernandez CE, Yen RW, Perez SM, Bedell HW, Povsic TJ, Reichert WM, Truskey GA Scientific reports 26888719 Sci Rep 2016 Feb 18
Tissue-engineered blood vessels as promising tools for testing drug toxicity. Truskey GA, Fernandez CE Expert opinion on drug metabolism & toxicology 26028128 Expert Opin Drug Metab Toxicol 2015 Jul
Striated muscle function, regeneration, and repair. Shadrin IY, Khodabukus A, Bursac N Cellular and molecular life sciences : CMLS 27271751 Cell Mol Life Sci 2016 Nov
Skin-inspired hydrogel-elastomer hybrids with robust interfaces and functional microstructures. Yuk H, Zhang T, Parada GA, Liu X, Zhao X Nature communications 27345380 Nat Commun 2016 Jun 27
Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions. Chan HF, Zhang Y, Leong KW Small (Weinheim an der Bergstrasse, Germany) 27038291 Small 2016 May
Multifunctionality and control of the crumpling and unfolding of large-area graphene. Zang J, Ryu S, Pugno N, Wang Q, Tu Q, Buehler MJ, Zhao X Nature materials 23334002 Nat Mater 2013 Apr
NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection. Juul S, Obliosca JM, Liu C, Liu YL, Chen YA, Imphean DM, Knudsen BR, Ho YP, Leong KW, Yeh HC Nanoscale 25901841 Nanoscale 2015 May 14
Synergizing Engineering and Biology to Treat and Model Skeletal Muscle Injury and Disease. Bursac N, Juhas M, Rando TA Annual review of biomedical engineering 26643021 Annu Rev Biomed Eng 2015
Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles. Davis BNJ, Santoso JW, Walker MJ, Oliver CE, Cunningham MM, Boehm CA, Dawes D, Lasater SL, Huffman K, Kraus WE, Truskey GA Annals of biomedical engineering 30963383 Ann Biomed Eng 2019 Jul
Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. Chen Z, Tang M, Huang D, Jiang W, Li M, Ji H, Park J, Xu B, Atchison LJ, Truskey GA, Leong KW Lab on a chip 29927449 Lab Chip 2018 Jul 10
Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle. Khodabukus A, Madden L, Prabhu NK, Koves TR, Jackman CP, Muoio DM, Bursac N Biomaterials 30180985 Biomaterials 2019 Apr
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy. Ousterout DG, Kabadi AM, Thakore PI, Majoros WH, Reddy TE, Gersbach CA Nature communications 25692716 Nat Commun 2015 Feb 18
Nanograting structure promotes lamellipodia-based cell collective migration and wound healing. Chen Z, Atchison L, Ji H, Leong KW Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 25570601 Annu Int Conf IEEE Eng Med Biol Soc 2014
Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome. Abutaleb NO, Atchison L, Choi L, Bedapudi A, Shores K, Gete Y, Cao K, Truskey GA Scientific reports 36977745 Sci Rep 2023 Mar 28
Engineering skeletal muscle repair. Juhas M, Bursac N Current opinion in biotechnology 23711735 Curr Opin Biotechnol 2013 Oct
Harnessing localized ridges for high-aspect-ratio hierarchical patterns with dynamic tunability and multifunctionality. Cao C, Chan HF, Zang J, Leong KW, Zhao X Advanced materials (Deerfield Beach, Fla.) 24339233 Adv Mater 2014 Mar 19
Bursting drops in solid dielectrics caused by high voltages. Wang Q, Suo Z, Zhao X Nature communications 23093194 Nat Commun 2012
Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems. Hong S, Jung Y, Yen R, Chan HF, Leong KW, Truskey GA, Zhao X Lab on a chip 24310854 Lab Chip 2014 Feb 7
Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Truskey GA, Achneck HE, Bursac N, Chan H, Cheng CS, Fernandez C, Hong S, Jung Y, Koves T, Kraus WE, Leong K, Madden L, Reichert WM, Zhao X Stem cell research & therapy 24565225 Stem Cell Res Ther 2013
Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. Ousterout DG, Kabadi AM, Thakore PI, Perez-Pinera P, Brown MT, Majoros WH, Reddy TE, Gersbach CA Molecular therapy : the journal of the American Society of Gene Therapy 25492562 Mol Ther 2015 Mar
Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis. Chakraborty S, Ji H, Chen J, Gersbach CA, Leong KW Scientific reports 25492703 Sci Rep 2014 Dec 10
Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors. Thakore PI, Gersbach CA Methods in molecular biology (Clifton, N.J.) 26443215 Methods Mol Biol 2016
Tough bonding of hydrogels to diverse non-porous surfaces. Yuk H, Zhang T, Lin S, Parada GA, Zhao X Nature materials 26552058 Nat Mater 2016 Feb
Engineering human pluripotent stem cells into a functional skeletal muscle tissue. Rao L, Qian Y, Khodabukus A, Ribar T, Bursac N Nature communications 29317646 Nat Commun 2018 Jan 9
Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL Scientific reports 28176881 Sci Rep 2017 Feb 8
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. Thakore PI, Kwon JB, Nelson CE, Rouse DC, Gemberling MP, Oliver ML, Gersbach CA Nature communications 29700298 Nat Commun 2018 Apr 26
Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues. Cheng CS, Ran L, Bursac N, Kraus WE, Truskey GA Tissue engineering. Part A 26891613 Tissue Eng Part A 2016 Apr
Engineered skeletal muscles for disease modeling and drug discovery. Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N Biomaterials 31419653 Biomaterials 2019 Nov
Distilling complexity to advance cardiac tissue engineering. Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G Science translational medicine 27280684 Sci Transl Med 2016 Jun 8
Advancing cardiovascular tissue engineering. Truskey GA F1000Research 27303643 F1000Res 2016
Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. Khodabukus A, Kaza A, Wang J, Prabhu N, Goldstein R, Vaidya VS, Bursac N Toxicological sciences : an official journal of the Society of Toxicology 32294208 Toxicol Sci 2020 Jul 1
Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Zhang D, Shadrin IY, Lam J, Xian HQ, Snodgrass HR, Bursac N Biomaterials 23642535 Biomaterials 2013 Jul
On-demand hierarchical patterning with electric fields. Wang Q, Robinson D, Zhao X Applied physics letters 25316923 Appl Phys Lett 2014 Jun 9
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. Madden L, Juhas M, Kraus WE, Truskey GA, Bursac N eLife 25575180 Elife 2015 Jan 9
Highly Aligned Nanofibrous Scaffold Derived from Decellularized Human Fibroblasts. Xing Q, Vogt C, Leong KW, Zhao F Advanced functional materials 25484849 Adv Funct Mater 2014 May 28
Human Cardiac Tissue Engineering: From Pluripotent Stem Cells to Heart Repair. Jackman CP, Shadrin IY, Carlson AL, Bursac N Current opinion in chemical engineering 25599018 Curr Opin Chem Eng 2015 Feb
3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Hong S, Sycks D, Chan HF, Lin S, Lopez GP, Guilak F, Leong KW, Zhao X Advanced materials (Deerfield Beach, Fla.) 26033288 Adv Mater 2015 Jul 15
The Development of TALE Nucleases for Biotechnology. Ousterout DG, Gersbach CA Methods in molecular biology (Clifton, N.J.) 26443211 Methods Mol Biol 2016
Use of flow, electrical, and mechanical stimulation to promote engineering of striated muscles. Rangarajan S, Madden L, Bursac N Annals of biomedical engineering 24366526 Ann Biomed Eng 2014 Jul
Materials innovation for co-delivery of diverse therapeutic cargos. Godsey ME, Suryaprakash S, Leong KW RSC advances 24818000 RSC Adv 2013 Dec 21
Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks. Zhao X Soft matter 24834901 Soft Matter 2014 Feb 7
Fringe instability in constrained soft elastic layers. Lin S, Cohen T, Zhang T, Yuk H, Abeyaratne R, Zhao X Soft matter 27731462 Soft Matter 2016 Nov 4
Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong KW PloS one 23785459 PLoS One 2013
Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. Fernandez CE, Obi-onuoha IC, Wallace CS, Satterwhite LL, Truskey GA, Reichert WM Acta biomaterialia 24140604 Acta Biomater 2014 Feb
Engineering mesenchymal stem cells for regenerative medicine and drug delivery. Park JS, Suryaprakash S, Lao YH, Leong KW Methods (San Diego, Calif.) 25770356 Methods 2015 Aug
Integration of drug, protein, and gene delivery systems with regenerative medicine. Lorden ER, Levinson HM, Leong KW Drug delivery and translational research 25787742 Drug Deliv Transl Res 2015 Apr
The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons. Kulangara K, Adler AF, Wang H, Chellappan M, Hammett E, Yasuda R, Leong KW Biomaterials 24709523 Biomaterials 2014 Jul
Nanotopography alters nuclear protein expression, proliferation and differentiation of human mesenchymal stem/stromal cells. Kulangara K, Yang J, Chellappan M, Yang Y, Leong KW PloS one 25521962 PLoS One 2014
Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies? Chan HF, Ma S, Leong KW Regenerative biomaterials 27047674 Regen Biomater 2016 Jun
Oxygen consumption in human, tissue-engineered myobundles during basal and electrical stimulation conditions. Davis BN, Yen R, Prasad V, Truskey GA APL bioengineering 31149650 APL Bioeng 2019 Jun
iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome. Atchison L, Abutaleb NO, Snyder-Mounts E, Gete Y, Ladha A, Ribar T, Cao K, Truskey GA Stem cell reports 32032552 Stem Cell Reports 2020 Feb 11
Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle. Kondash ME, Ananthakumar A, Khodabukus A, Bursac N, Truskey GA Tissue engineering and regenerative medicine 32200516 Tissue Eng Regen Med 2020 Dec
Modeling statin myopathy in a human skeletal muscle microphysiological system. Ananthakumar A, Liu Y, Fernandez CE, Truskey GA, Voora D PloS one 33237943 PLoS One 2020
A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles. Zhang X, Hong S, Yen R, Kondash M, Fernandez CE, Truskey GA Lab on a chip 30112530 Lab Chip 2018 Sep 11
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide. Wang HX, Song Z, Lao YH, Xu X, Gong J, Cheng D, Chakraborty S, Park JS, Li M, Huang D, Yin L, Cheng J, Leong KW Proceedings of the National Academy of Sciences of the United States of America 29686087 Proc Natl Acad Sci U S A 2018 May 8
A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells. Atchison L, Zhang H, Cao K, Truskey GA Scientific reports 28811655 Sci Rep 2017 Aug 15
Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity. Davis BN, Santoso JW, Walker MJ, Cheng CS, Koves TR, Kraus WE, Truskey GA Tissue engineering. Part C, Methods 28338413 Tissue Eng Part C Methods 2017 Apr
In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease. Khodabukus A, Prabhu N, Wang J, Bursac N Advanced healthcare materials 29696831 Adv Healthc Mater 2018 Aug
Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. Cheng CS, El-Abd Y, Bui K, Hyun YE, Hughes RH, Kraus WE, Truskey GA American journal of physiology. Cell physiology 24336652 Am J Physiol Cell Physiol 2014 Feb 15
A CRISPR/Cas9-based system for reprogramming cell lineage specification. Chakraborty S, Ji H, Kabadi AM, Gersbach CA, Christoforou N, Leong KW Stem cell reports 25448066 Stem Cell Reports 2014 Dec 9
MicroRNA delivery for regenerative medicine. Peng B, Chen Y, Leong KW Advanced drug delivery reviews 26024978 Adv Drug Deliv Rev 2015 Jul 1
Enabling functional genomics with genome engineering. Hilton IB, Gersbach CA Genome research 26430154 Genome Res 2015 Oct
Transdifferentiation of human endothelial progenitors into smooth muscle cells. Ji H, Atchison L, Chen Z, Chakraborty S, Jung Y, Truskey GA, Christoforou N, Leong KW Biomaterials 26874281 Biomaterials 2016 Apr
High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. McGarrah RW, Craig DM, Haynes C, Dowdy ZE, Shah SH, Kraus WE Atherosclerosis 26803432 Atherosclerosis 2016 Mar
Stretchable Hydrogel Electronics and Devices. Lin S, Yuk H, Zhang T, Parada GA, Koo H, Yu C, Zhao X Advanced materials (Deerfield Beach, Fla.) 26639322 Adv Mater 2016 Jun
A versatile platform for surface modification of microfluidic droplets. Li M, Jiang W, Chen Z, Suryaprakash S, Lv S, Tang Z, Chen X, Leong KW Lab on a chip 28154857 Lab Chip 2017 Feb 14
Dynamic culture yields engineered myocardium with near-adult functional output. Jackman CP, Carlson AL, Bursac N Biomaterials 27723557 Biomaterials 2016 Dec
Development of a microphysiological model of human kidney proximal tubule function. Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ Kidney international 27521113 Kidney Int 2016 Sep
Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function. Chang SY, Weber EJ, Ness KV, Eaton DL, Kelly EJ Clinical pharmacology and therapeutics 27448090 Clin Pharmacol Ther 2016 Nov
Human Organ-Specific Endothelial Cell Heterogeneity. Marcu R, Choi YJ, Xue J, Fortin CL, Wang Y, Nagao RJ, Xu J, MacDonald JW, Bammler TK, Murry CE, Muczynski K, Stevens KR, Himmelfarb J, Schwartz SM, Zheng Y iScience 30240741 iScience 2018 Jun 29
Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection. Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M Gut microbes 32378997 Gut Microbes 2020 Nov 9
Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA Toxicology in vitro : an international journal published in association with BIBRA 31857146 Toxicol In Vitro 2020 Mar
Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ Toxicology 32905824 Toxicology 2020 Nov
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Lidberg KA, Annalora AJ, Jozic M, Elson DJ, Wang L, Bammler TK, Ramm S, Monteiro MB, Himmelfarb J, Marcus CB, Iversen PL, Kelly EJ Scientific reports 33633318 Sci Rep 2021 Feb 25
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M Gastroenterology 26677983 Gastroenterology 2016 Mar
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease. Cruz NM, Song X, Czerniecki SM, Gulieva RE, Churchill AJ, Kim YK, Winston K, Tran LM, Diaz MA, Fu H, Finn LS, Pei Y, Himmelfarb J, Freedman BS Nature materials 28967916 Nat Mater 2017 Nov
Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. Campanholle G, Ligresti G, Gharib SA, Duffield JS American journal of physiology. Cell physiology 23325411 Am J Physiol Cell Physiol 2013 Apr 1
Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. Hung C, Linn G, Chow YH, Kobayashi A, Mittelsteadt K, Altemeier WA, Gharib SA, Schnapp LM, Duffield JS American journal of respiratory and critical care medicine 23924232 Am J Respir Crit Care Med 2013 Oct 1
Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD, Kelly EJ, Himmelfarb J, Unadkat JD Drug metabolism and disposition: the biological fate of chemicals 27621205 Drug Metab Dispos 2016 Dec
Development of a Kidney Microphysiological System Hardware Platform for Microgravity Studies. Yeung C, Jones-Isaac K, Lindberg K, Yang J, Bain J, Ruiz M, Koenig G, Koenig P, Countryman S, Himmelfarb J, Kelly E Research square 38196654 Res Sq 2023 Dec 22
Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system. Lidberg KA, Jones-Isaac K, Yang J, Bain J, Wang L, MacDonald JW, Bammler TK, Calamia J, Thummel KE, Yeung CK, Countryman S, Koenig P, Himmelfarb J, Kelly EJ NPJ microgravity 38982119 NPJ Microgravity 2024 Jul 9
A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS Journal of the American Society of Nephrology : JASN 26260164 J Am Soc Nephrol 2016 Apr
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, Himmelfarb J Stem cell research & therapy 24564863 Stem Cell Res Ther 2013
TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease. Gomez IG, Roach AM, Nakagawa N, Amatucci A, Johnson BG, Dunn K, Kelly MC, Karaca G, Zheng TS, Szak S, Peppiatt-Wildman CM, Burkly LC, Duffield JS Journal of the American Society of Nephrology : JASN 27026366 J Am Soc Nephrol 2016 Dec
RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis. Craciun FL, Bijol V, Ajay AK, Rao P, Kumar RK, Hutchinson J, Hofmann O, Joshi N, Luyendyk JP, Kusebauch U, Moss CL, Srivastava A, Himmelfarb J, Waikar SS, Moritz RL, Vaidya VS Journal of the American Society of Nephrology : JASN 26449608 J Am Soc Nephrol 2016 Jun
Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci. Sieber KB, Batorsky A, Siebenthall K, Hudkins KL, Vierstra JD, Sullivan S, Sur A, McNulty M, Sandstrom R, Reynolds A, Bates D, Diegel M, Dunn D, Nelson J, Buckley M, Kaul R, Sampson MG, Himmelfarb J, Alpers CE, Waterworth D, Akilesh S Journal of the American Society of Nephrology : JASN 30760496 J Am Soc Nephrol 2019 Mar
High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Czerniecki SM, Cruz NM, Harder JL, Menon R, Annis J, Otto EA, Gulieva RE, Islas LV, Kim YK, Tran LM, Martins TJ, Pippin JW, Fu H, Kretzler M, Shankland SJ, Himmelfarb J, Moon RT, Paragas N, Freedman BS Cell stem cell 29779890 Cell Stem Cell 2018 Jun 1
A Novel Three-Dimensional Human Peritubular Microvascular System. Ligresti G, Nagao RJ, Xue J, Choi YJ, Xu J, Ren S, Aburatani T, Anderson SK, MacDonald JW, Bammler TK, Schwartz SM, Muczynski KA, Duffield JS, Himmelfarb J, Zheng Y Journal of the American Society of Nephrology : JASN 26657868 J Am Soc Nephrol 2016 Aug
A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS Journal of the American Society of Nephrology : JASN 30361326 J Am Soc Nephrol 2018 Dec
Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ JCI insight 30568031 JCI Insight 2018 Dec 20
Kidney microphysiological models for nephrotoxicity assessment. Mahadeo A, Yeung CK, Himmelfarb J, Kelly EJ Current opinion in toxicology 35495549 Curr Opin Toxicol 2022 Jun
Development of a kidney microphysiological system hardware platform for microgravity studies. Jones-Isaac KA, Lidberg KA, Yeung CK, Yang J, Bain J, Ruiz M, Koenig G, Koenig P, Countryman S, Himmelfarb J, Kelly EJ NPJ microgravity 38734683 NPJ Microgravity 2024 May 11
The inexorable rise of AKI: can we bend the growth curve? Siew ED, Himmelfarb J Journal of the American Society of Nephrology : JASN 23243210 J Am Soc Nephrol 2013 Jan
Changes in macrophage phenotype as the immune response evolves. Lichtnekert J, Kawakami T, Parks WC, Duffield JS Current opinion in pharmacology 23747023 Curr Opin Pharmacol 2013 Aug
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. Yeung CK, Shen DD, Thummel KE, Himmelfarb J Kidney international 24132209 Kidney Int 2014 Mar
EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield JS Journal of the American Society of Nephrology : JASN 23492730 J Am Soc Nephrol 2013 Mar
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia. Cruz NM, Reddy R, McFaline-Figueroa JL, Tran C, Fu H, Freedman BS Nature biomedical engineering 35478224 Nat Biomed Eng 2022 Apr
Cellular and molecular mechanisms in kidney fibrosis. Duffield JS The Journal of clinical investigation 24892703 J Clin Invest 2014 Jun
Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS. Kawakami T, Gomez IG, Ren S, Hudkins K, Roach A, Alpers CE, Shankland SJ, D'Agati VD, Duffield JS Journal of the American Society of Nephrology : JASN 25406339 J Am Soc Nephrol 2015 May
Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel. Hiraki HL, Nagao RJ, Himmelfarb J, Zheng Y Journal of visualized experiments : JoVE 30371659 J Vis Exp 2018 Oct 13
Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble-Mediated Drug Delivery. Juang EK, De Cock I, Keravnou C, Gallagher MK, Keller SB, Zheng Y, Averkiou M Langmuir : the ACS journal of surfaces and colloids 30540481 Langmuir 2019 Aug 6
A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis. Miller CP, Tsuchida C, Zheng Y, Himmelfarb J, Akilesh S Neoplasia (New York, N.Y.) 29747161 Neoplasia 2018 Jun
Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. Kotha S, Sun S, Adams A, Hayes B, Phong KT, Nagao R, Reems JA, Gao D, Torok-Storb B, López JA, Zheng Y PloS one 29617409 PLoS One 2018
Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury. Chen YT, Chang YT, Pan SY, Chou YH, Chang FC, Yeh PY, Liu YH, Chiang WC, Chen YM, Wu KD, Tsai TJ, Duffield JS, Lin SL Journal of the American Society of Nephrology : JASN 24854266 J Am Soc Nephrol 2014 Dec
Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. Weber EJ, Himmelfarb J, Kelly EJ Current opinion in toxicology 29057384 Curr Opin Toxicol 2017 Jun
Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Watson DE, Hunziker R, Wikswo JP Experimental biology and medicine (Maywood, N.J.) 29065799 Exp Biol Med (Maywood) 2017 Oct
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease. Nakagawa N, Barron L, Gomez IG, Johnson BG, Roach AM, Kameoka S, Jack RM, Lupher ML Jr, Gharib SA, Duffield JS JCI insight 27942582 JCI Insight 2016 Dec 8
Impact of microgravity on a three-dimensional microphysiologic culture of the human kidney proximal tubule epithelium: cell response to serum and vitamin D. Kelly E, Lindberg K, Jones-Isaac K, Yang J, Bain J, Wang L, MacDonald J, Bammler T, Calamia J, Thummel K, Yeung C, Countryman S, Koenig P, Himmelfarb J Research square 38196580 Res Sq 2023 Dec 21
Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease. Li SR, Gulieva RE, Helms L, Cruz NM, Vincent T, Fu H, Himmelfarb J, Freedman BS Nature communications 36564419 Nat Commun 2022 Dec 23
Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease. Juliar BA, Stanaway IB, Sano F, Fu H, Smith KD, Akilesh S, Scales SJ, El Saghir J, Bhatraju PK, Liu E, Yang J, Lin J, Eddy S, Kretzler M, Zheng Y, Himmelfarb J, Harder JL, Freedman BS Cell reports 38838223 Cell Rep 2024 Jun 25
Pericytes in kidney fibrosis. Ren S, Duffield JS Current opinion in nephrology and hypertension 23722183 Curr Opin Nephrol Hypertens 2013 Jul
Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS Journal of immunology (Baltimore, Md. : 1950) 23956422 J Immunol 2013 Sep 15
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL Toxicology in vitro : an international journal published in association with BIBRA 28089783 Toxicol In Vitro 2017 Apr
Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. Bhatraju PK, Cohen M, Nagao RJ, Morrell ED, Kosamo S, Chai XY, Nance R, Dmyterko V, Delaney J, Christie JD, Liu KD, Mikacenic C, Gharib SA, Liles WC, Zheng Y, Christiani DC, Himmelfarb J, Wurfel MM BMC nephrology 32680471 BMC Nephrol 2020 Jul 17
Tissue-engineered microenvironment systems for modeling human vasculature. Tourovskaia A, Fauver M, Kramer G, Simonson S, Neumann T Experimental biology and medicine (Maywood, N.J.) 25030480 Exp Biol Med (Maywood) 2014 Sep
Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. Maass C, Sorensen NB, Himmelfarb J, Kelly EJ, Stokes CL, Cirit M CPT: pharmacometrics & systems pharmacology 30869201 CPT Pharmacometrics Syst Pharmacol 2019 May
A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro. Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS Toxicological sciences : an official journal of the Society of Toxicology 30649541 Toxicol Sci 2019 May 1
Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL JCI insight 29202460 JCI Insight 2017 Nov 16
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I Scientific reports 30291268 Sci Rep 2018 Oct 5
Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G Drug metabolism and disposition: the biological fate of chemicals 30076203 Drug Metab Dispos 2018 Nov
Reconstructing the Human Renal Vascular-Tubular Unit In Vitro. Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y Advanced healthcare materials 30379416 Adv Healthc Mater 2018 Dec
Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component? Cyr KJ, Avaldi OM, Wikswo JP Experimental biology and medicine (Maywood, N.J.) 29065796 Exp Biol Med (Maywood) 2017 Nov
Microphysiological Systems to Assess Nonclinical Toxicity. Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ Current protocols in toxicology 28777442 Curr Protoc Toxicol 2017 Aug 4
Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27871064 FASEB J 2017 Feb
Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS The Journal of clinical investigation 25415439 J Clin Invest 2015 Jan
The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury. Gomez IG, Duffield JS Kidney international supplements 26312147 Kidney Int Suppl (2011) 2014 Nov
Cyclosporine Induces Fenestra-Associated Injury in Human Renal Microvessels In Vitro. Nagao RJ, Marcu R, Shin YJ, Lih D, Xue J, Arang N, Wei L, Akilesh S, Kaushansky A, Himmelfarb J, Zheng Y ACS biomaterials science & engineering 34927415 ACS Biomater Sci Eng 2022 Jan 10
Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism. Yamaura Y, Chapron BD, Wang Z, Himmelfarb J, Thummel KE Drug metabolism and disposition: the biological fate of chemicals 26700954 Drug Metab Dispos 2016 Mar
Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence. Nagao RJ, Xu J, Luo P, Xue J, Wang Y, Kotha S, Zeng W, Fu X, Himmelfarb J, Zheng Y Tissue engineering. Part A 27481445 Tissue Eng Part A 2016 Oct
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS The Journal of clinical investigation 27869651 J Clin Invest 2017 Jan 3
Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS Translational research : the journal of laboratory and clinical medicine 27815136 Transl Res 2017 Apr
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Li X, George SM, Vernetti L, Gough AH, Taylor DL Lab on a chip 30063238 Lab Chip 2018 Aug 21
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Sakolish C, Reese CE, Luo YS, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Chiu WA, Vernetti LA, Rusyn I Toxicology 33307106 Toxicology 2021 Jan 30
Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Sakolish C, Luo YS, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA Toxicology 34543702 Toxicology 2021 Nov
In vitro platforms for evaluating liver toxicity. Bale SS, Vernetti L, Senutovitch N, Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta BO, Taylor DL, Yarmush ML Experimental biology and medicine (Maywood, N.J.) 24764241 Exp Biol Med (Maywood) 2014 Sep
SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. Tobita T, Guzman-Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, Deng CX, Collin de l'Hortet A, Soto-Gutierrez A PloS one 26890260 PLoS One 2016
Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies. Usta OB, McCarty WJ, Bale S, Hegde M, Jindal R, Bhushan A, Golberg I, Yarmush ML Technology 26167518 Technology (Singap World Sci) 2015 Mar
A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation. McCarty WJ, Usta OB, Yarmush ML Scientific reports 27240736 Sci Rep 2016 May 31
A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. Stern AM, Schurdak ME, Bahar I, Berg JM, Taylor DL Journal of biomolecular screening 26962875 J Biomol Screen 2016 Jul
Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems. Soto-Gutierrez A, Gough A, Vernetti LA, Taylor DL, Monga SP Experimental biology and medicine (Maywood, N.J.) 28467181 Exp Biol Med (Maywood) 2017 Oct
Development and validation of a microfluidic immunoassay capable of multiplexing parallel samples in microliter volumes. Ghodbane M, Stucky EC, Maguire TJ, Schloss RS, Shreiber DI, Zahn JD, Yarmush ML Lab on a chip 26130452 Lab Chip 2015 Aug 7
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, Fondevila C, Stärkel P, Dubuquoy L, Louvet A, Odena G, Gomez JL, Aragon T, Altamirano J, Caballeria J, Jurczak MJ, Taylor DL, Berasain C, Wahlestedt C, Monga SP, Morgan MY, Sancho-Bru P, Mathurin P, Furuya S, Lackner C, Rusyn I, Shah VH, Thursz MR, Mann J, Avila MA, Bataller R Nature communications 31311938 Nat Commun 2019 Jul 16
Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems. Lee-Montiel FT, George SM, Gough AH, Sharma AD, Wu J, DeBiasio R, Vernetti LA, Taylor DL Experimental biology and medicine (Maywood, N.J.) 28409533 Exp Biol Med (Maywood) 2017 Oct
iPSC-Derived Neurons from Patients with POLG Mutations Exhibit Decreased Mitochondrial Content and Dendrite Simplification. Verma M, Francis L, Lizama BN, Callio J, Fricklas G, Wang KZQ, Kaufman BA, D'Aiuto L, Stolz DB, Watkins SC, Nimgaonkar VL, Soto-Gutierrez A, Goldstein A, Chu CT The American journal of pathology 36414085 Am J Pathol 2023 Feb
Fluorescent protein biosensors applied to microphysiological systems. Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor DL Experimental biology and medicine (Maywood, N.J.) 25990438 Exp Biol Med (Maywood) 2015 Jun
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL PloS one 25036749 PLoS One 2014
Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells. Bale SS, Golberg I, Jindal R, McCarty WJ, Luitje M, Hegde M, Bhushan A, Usta OB, Yarmush ML Tissue engineering. Part C, Methods 25233394 Tissue Eng Part C Methods 2015 Apr
Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform. Hegde M, Jindal R, Bhushan A, Bale SS, McCarty WJ, Golberg I, Usta OB, Yarmush ML Lab on a chip 24770663 Lab Chip 2014 Jun 21
Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization. McCarty WJ, Prodanov L, Bale SS, Bhushan A, Jindal R, Yarmush ML, Usta OB Journal of visualized experiments : JoVE 26485274 J Vis Exp 2015 Sep 29
Liver metastases: Microenvironments and ex-vivo models. Clark AM, Ma B, Taylor DL, Griffith L, Wells A Experimental biology and medicine (Maywood, N.J.) 27390264 Exp Biol Med (Maywood) 2016 Sep
Human organoid cultures: transformative new tools for human virus studies. Ramani S, Crawford SE, Blutt SE, Estes MK Current opinion in virology 29656244 Curr Opin Virol 2018 Apr
Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M Nature reviews. Gastroenterology & hepatology 27677718 Nat Rev Gastroenterol Hepatol 2016 Nov
Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MK American journal of physiology. Gastrointestinal and liver physiology 34288725 Am J Physiol Gastrointest Liver Physiol 2021 Sep 1
Applications of the microphysiology systems database for experimental ADME-Tox and disease models. Schurdak M, Vernetti L, Bergenthal L, Wolter QK, Shun TY, Karcher S, Taylor DL, Gough A Lab on a chip 32211684 Lab Chip 2020 Apr 14
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®. Bircsak KM, DeBiasio R, Miedel M, Alsebahi A, Reddinger R, Saleh A, Shun T, Vernetti LA, Gough A Toxicology 33359578 Toxicology 2021 Feb 28
Human Hepatocellular response in Cholestatic Liver Diseases. Ortiz K, Cetin Z, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Ostrowska A, Soto-Gutierrez A, Faccioli LAP Organogenesis 37598346 Organogenesis 2023 Dec 31
Liver-Regenerative Transplantation: Regrow and Reset. Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Handa K, Matsubara K, Fukumitsu K, Dorko K, Presnell SC, Yagi H, Soto-Gutierrez A American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 26699680 Am J Transplant 2016 Jun
A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture. McCarty WJ, Usta OB, Luitje M, Bale SS, Bhushan A, Hegde M, Golberg I, Jindal R, Yarmush ML Technology 24932459 Technology (Singap World Sci) 2014 Mar
Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes. Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM Oncology 29306943 Oncology 2018
Biotunable acoustic node assembly of organoids. Chen P, Güven S, Usta OB, Yarmush ML, Demirci U Advanced healthcare materials 26149464 Adv Healthc Mater 2015 Sep 16
Biologically Relevant Heterogeneity: Metrics and Practical Insights. Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL SLAS discovery : advancing life sciences R & D 28231035 SLAS Discov 2017 Mar
Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response. Bale SS, Geerts S, Jindal R, Yarmush ML Scientific reports 27142224 Sci Rep 2016 May 4
Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. Bhushan A, Senutovitch N, Bale SS, McCarty WJ, Hegde M, Jindal R, Golberg I, Berk Usta O, Yarmush ML, Vernetti L, Gough A, Bakan A, Shun TY, DeBiasio R, Lansing Taylor D Stem cell research & therapy 24565476 Stem Cell Res Ther 2013
The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models. Gough A, Vernetti L, Bergenthal L, Shun TY, Taylor DL Applied in vitro toxicology 28781990 Appl In Vitro Toxicol 2016 Jun 1
Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy. Vernetti LA, Vogt A, Gough A, Taylor DL Clinics in liver disease 27842772 Clin Liver Dis 2017 Feb
Development of a low-volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization. Ghodbane M, Kulesa A, Yu HH, Maguire TJ, Schloss RR, Ramachandran R, Zahn JD, Yarmush ML Microfluidics and nanofluidics 25691853 Microfluid Nanofluidics 2015 Feb
Long-term maintenance of a microfluidic 3D human liver sinusoid. Prodanov L, Jindal R, Bale SS, Hegde M, McCarty WJ, Golberg I, Bhushan A, Yarmush ML, Usta OB Biotechnology and bioengineering 26152452 Biotechnol Bioeng 2016 Jan
A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Vernetti LA, Senutovitch N, Boltz R, DeBiasio R, Shun TY, Gough A, Taylor DL Experimental biology and medicine (Maywood, N.J.) 26202373 Exp Biol Med (Maywood) 2016 Jan
A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity. Bale SS, Sridharan GV, Golberg I, Prodanov L, McCarty WJ, Usta OB, Jindal R, Yarmush ML Technology 26925437 Technology (Singap World Sci) 2015 Dec
Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants. Faccioli LAP, Cetin Z, Kocas-Kilicarslan ZN, Ortiz K, Sun Y, Hu Z, Kurihara T, Tafaleng EN, Florentino RM, Wang Z, Xia M, Miedel MT, Taylor DL, Behari J, Ostrowska A, Constantine R, Li A, Soto-Gutierrez A International journal of molecular sciences 37686209 Int J Mol Sci 2023 Aug 29
Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling. Beckwitt CH, Shiraha K, Wells A PloS one 29763460 PLoS One 2018
High resolution stereolithography fabrication of perfusable scaffolds to enable long-term meso-scale hepatic culture for disease modeling. Sphabmixay P, Raredon MSB, Wang AJ, Lee H, Hammond PT, Fang NX, Griffith LG Biofabrication 34479229 Biofabrication 2021 Sep 21
Bioreactor technologies to support liver function in vitro. Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG Advanced drug delivery reviews 24607703 Adv Drug Deliv Rev 2014 Apr
A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. Clark AM, Wheeler SE, Young CL, Stockdale L, Shepard Neiman J, Zhao W, Stolz DB, Venkataramanan R, Lauffenburger D, Griffith L, Wells A Lab on a chip 27910972 Lab Chip 2016 Dec 20
Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer. Ma B, Khazali A, Shao H, Jiang Y, Wells A Cell communication and signaling : CCS 31831069 Cell Commun Signal 2019 Dec 12
The dormancy dilemma: quiescence versus balanced proliferation. Wells A, Griffith L, Wells JZ, Taylor DP Cancer research 23794703 Cancer Res 2013 Jul 1
Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes. Wang AJ, Allen A, Sofman M, Sphabmixay P, Yildiz E, Griffith LG Advanced nanobiomed research 35872804 Adv Nanobiomed Res 2022 Jan
Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. Grahovac J, Wells A Laboratory investigation; a journal of technical methods and pathology 24247562 Lab Invest 2014 Jan
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR Drug metabolism and disposition: the biological fate of chemicals 25926431 Drug Metab Dispos 2015 Jul
All-human microphysical model of metastasis therapy. Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, Wells A, Young C Stem cell research & therapy 24565274 Stem Cell Res Ther 2013
Modeling boundary conditions for balanced proliferation in metastatic latency. Taylor DP, Wells JZ, Savol A, Chennubhotla C, Wells A Clinical cancer research : an official journal of the American Association for Cancer Research 23329811 Clin Cancer Res 2013 Mar 1
Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Warita K, Warita T, Beckwitt CH, Schurdak ME, Vazquez A, Wells A, Oltvai ZN Scientific reports 25534349 Sci Rep 2014 Dec 23
CXCR3 in carcinoma progression. Ma B, Khazali A, Wells A Histology and histopathology 25663474 Histol Histopathol 2015 Jul
Tenascin-C Signaling in melanoma. Shao H, Kirkwood JM, Wells A Cell adhesion & migration 25482624 Cell Adh Migr 2015
The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells. Ma B, Wells A The Journal of biological chemistry 24619413 J Biol Chem 2014 Apr 18
Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT Drug discovery today 24793141 Drug Discov Today 2014 Jun
Liver 'organ on a chip'. Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A Experimental cell research 29291400 Exp Cell Res 2018 Feb 1
Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems. Stokes CL, Cirit M, Lauffenburger DA CPT: pharmacometrics & systems pharmacology 26535154 CPT Pharmacometrics Syst Pharmacol 2015 Oct
Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS). Maass C, Stokes CL, Griffith LG, Cirit M Integrative biology : quantitative biosciences from nano to macro 28267162 Integr Biol (Camb) 2017 Apr 18
Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform. Long TJ, Cosgrove PA, Dunn RT 2nd, Stolz DB, Hamadeh H, Afshari C, McBride H, Griffith LG Drug metabolism and disposition: the biological fate of chemicals 27621203 Drug Metab Dispos 2016 Dec
Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M CPT: pharmacometrics & systems pharmacology 26535159 CPT Pharmacometrics Syst Pharmacol 2015 Oct
Liver protects metastatic prostate cancer from induced death by activating E-cadherin signaling. Ma B, Wheeler SE, Clark AM, Whaley DL, Yang M, Wells A Hepatology (Baltimore, Md.) 27482645 Hepatology 2016 Nov
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies. Tsamandouras N, Chen WLK, Edington CD, Stokes CL, Griffith LG, Cirit M The AAPS journal 28752430 AAPS J 2017 Sep
Modeling the Complexity of the Metastatic Niche Ex Vivo. Clark AM Methods in molecular biology (Clifton, N.J.) 33340364 Methods Mol Biol 2021
Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies. Maass C, Dallas M, LaBarge ME, Shockley M, Valdez J, Geishecker E, Stokes CL, Griffith LG, Cirit M Scientific reports 29789564 Sci Rep 2018 May 22
Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Dioufa N, Clark AM, Ma B, Beckwitt CH, Wells A Molecular cancer 29137633 Mol Cancer 2017 Nov 14
Biomarker identification for statin sensitivity of cancer cell lines. Raghu VK, Beckwitt CH, Warita K, Wells A, Benos PV, Oltvai ZN Biochemical and biophysical research communications 29146185 Biochem Biophys Res Commun 2018 Jan 1
Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation. Cambria E, Renggli K, Ahrens CC, Cook CD, Kroll C, Krueger AT, Imperiali B, Griffith LG Biomacromolecules 26098148 Biomacromolecules 2015 Aug 10
Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Taylor DP, Clark A, Wheeler S, Wells A Breast cancer research and treatment 24610032 Breast Cancer Res Treat 2014 Apr
A microphysiological system model of therapy for liver micrometastases. Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A Experimental biology and medicine (Maywood, N.J.) 24821820 Exp Biol Med (Maywood) 2014 Sep
Glucocorticoid Clearance and Metabolite Profiling in an In Vitro Human Airway Epithelium Lung Model. Rivera-Burgos D, Sarkar U, Lever AR, Avram MJ, Coppeta JR, Wishnok JS, Borenstein JT, Tannenbaum SR Drug metabolism and disposition: the biological fate of chemicals 26586376 Drug Metab Dispos 2016 Feb
MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. Kader M, Alaoui-El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N PLoS pathogens 29049365 PLoS Pathog 2017 Oct
IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment. Clark AM, Heusey HL, Griffith LG, Lauffenburger DA, Wells A Frontiers in oncology 34123844 Front Oncol 2021
Engineering liver. Griffith LG, Wells A, Stolz DB Hepatology (Baltimore, Md.) 24668880 Hepatology 2014 Oct
Photopatterning of hydrogel scaffolds coupled to filter materials using stereolithography for perfused 3D culture of hepatocytes. Neiman JA, Raman R, Chan V, Rhoads MG, Raredon MS, Velazquez JJ, Dyer RL, Bashir R, Hammond PT, Griffith LG Biotechnology and bioengineering 25384798 Biotechnol Bioeng 2015 Apr
Adult Stem Cell Functioning in the Tumor Micro-Environment. Jiang Y, Wells A, Sylakowski K, Clark AM, Ma B International journal of molecular sciences 31130595 Int J Mol Sci 2019 May 25
Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk. Chen WLK, Edington C, Suter E, Yu J, Velazquez JJ, Velazquez JG, Shockley M, Large EM, Venkataramanan R, Hughes DJ, Stokes CL, Trumper DL, Carrier RL, Cirit M, Griffith LG, Lauffenburger DA Biotechnology and bioengineering 28667746 Biotechnol Bioeng 2017 Nov
A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer. Korentzelos D, Clark AM, Wells A International journal of molecular sciences 33022920 Int J Mol Sci 2020 Oct 3
Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy. Khazali AS, Clark AM, Wells A British journal of cancer 29169181 Br J Cancer 2018 Feb 20
A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. Clark AM, Kumar MP, Wheeler SE, Young CL, Venkataramanan R, Stolz DB, Griffith LG, Lauffenburger DA, Wells A Molecular & cellular proteomics : MCP 29353230 Mol Cell Proteomics 2018 Apr
On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. Valdez J, Cook CD, Ahrens CC, Wang AJ, Brown A, Kumar M, Stockdale L, Rothenberg D, Renggli K, Gordon E, Lauffenburger D, White F, Griffith L Biomaterials 28371736 Biomaterials 2017 Jun
The pan-therapeutic resistance of disseminated tumor cells: Role of phenotypic plasticity and the metastatic microenvironment. Ma B, Wells A, Clark AM Seminars in cancer biology 31376430 Semin Cancer Biol 2020 Feb
Integrative microphysiological tissue systems of cancer metastasis to the liver. Clark AM, Allbritton NL, Wells A Seminars in cancer biology 32580025 Semin Cancer Biol 2021 Jun
Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells. Furukawa M, Wheeler S, Clark AM, Wells A PloS one 25635394 PLoS One 2015
Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. Wheeler SE, Clark AM, Taylor DP, Young CL, Pillai VC, Stolz DB, Venkataramanan R, Lauffenburger D, Griffith L, Wells A British journal of cancer 25314052 Br J Cancer 2014 Dec 9
Use of ChemoFx® for Identification of Effective Treatments in Epithelial Ovarian Cancer. Richard S, Wells A, Connor J, Price F PLoS currents 26213638 PLoS Curr 2015 Jul 13
Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. Yang M, Ma B, Shao H, Clark AM, Wells A BMC cancer 27387344 BMC Cancer 2016 Jul 7
Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System. Tsamandouras N, Kostrzewski T, Stokes CL, Griffith LG, Hughes DJ, Cirit M The Journal of pharmacology and experimental therapeutics 27760784 J Pharmacol Exp Ther 2017 Jan
A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms. Khazali AS, Clark AM, Wells A Stem cell reviews and reports 28425064 Stem Cell Rev Rep 2017 Jun
Patterned polymer matrix promotes stemness and cell-cell interaction of adult stem cells. Hofmeister LH, Costa L, Balikov DA, Crowder SW, Terekhov A, Sung HJ, Hofmeister WH Journal of biological engineering 26464581 J Biol Eng 2015
Cerebral Waste Accumulation and Glymphatic Clearance as Mechanisms of Human Neurological Diseases. Dadas A, Washington J, Janigro D Journal of neurology & neuromedicine 30506062 J Neurol Neuromedicine 2016
Oligoproline-derived nanocarrier for dual stimuli-responsive gene delivery. Gupta MK , Lee SH , Crowder SW , Wang X , Hofmeister LH , Nelson CE , Bellan LM , Duvall CL , Sung HJ Journal of materials chemistry. B 32262835 J Mater Chem B 2015 Sep 28
Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. Puvenna V, Brennan C, Shaw G, Yang C, Marchi N, Bazarian JJ, Merchant-Borna K, Janigro D PloS one 24806476 PLoS One 2014
Poly(ε-caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells. Crowder SW, Liang Y, Rath R, Park AM, Maltais S, Pintauro PN, Hofmeister W, Lim CC, Wang X, Sung HJ Nanomedicine (London, England) 23530764 Nanomedicine (Lond) 2013 Nov
New immunological approaches in treating and diagnosing CNS diseases. Guo K, Janigro D Pharmaceutical patent analyst 24237062 Pharm Pat Anal 2013 May
Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels. Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ Biomaterials 25154665 Biomaterials 2014 Dec
Systems-level view of cocaine addiction: the interconnection of the immune and nervous systems. Marasco CC, Goodwin CR, Winder DG, Schramm-Sapyta NL, McLean JA, Wikswo JP Experimental biology and medicine (Maywood, N.J.) 24903164 Exp Biol Med (Maywood) 2014 Nov
Bond-specific dissociation following excitation energy transfer for distance constraint determination in the gas phase. Hendricks NG, Lareau NM, Stow SM, McLean JA, Julian RR Journal of the American Chemical Society 25174489 J Am Chem Soc 2014 Sep 24
ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response. Lee SH, Boire TC, Lee JB, Gupta MK, Zachman AL, Rath R, Sung HJ Journal of materials chemistry. B 25343029 J Mater Chem B 2014 Nov 7
Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. Ghosh C, Hossain M, Spriggs A, Ghosh A, Grant GA, Marchi N, Perucca E, Janigro D Epilepsia 25656284 Epilepsia 2015 Mar
Ion mobility-mass spectrometry: time-dispersive instrumentation. May JC, McLean JA Analytical chemistry 25526595 Anal Chem 2015 Feb 3
S100B blood levels and childhood trauma in adolescent inpatients. Falcone T, Janigro D, Lovell R, Simon B, Brown CA, Herrera M, Myint AM, Anand A Journal of psychiatric research 25669696 J Psychiatr Res 2015 Mar
Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry. Hines KM, May JC, McLean JA, Xu L Analytical chemistry 27321977 Anal Chem 2016 Jul 19
Detection of brain-directed autoantibodies in the serum of non-small cell lung cancer patients. Banjara M, Ghosh C, Dadas A, Mazzone P, Janigro D PloS one 28746384 PLoS One 2017
A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box. Cucullo L, Hossain M, Tierney W, Janigro D BMC neuroscience 23388041 BMC Neurosci 2013 Feb 6
Differential responses of induced pluripotent stem cell-derived cardiomyocytes to anisotropic strain depends on disease status. Chun YW, Voyles DE, Rath R, Hofmeister LH, Boire TC, Wilcox H, Lee JH, Bellan LM, Hong CC, Sung HJ Journal of biomechanics 26476764 J Biomech 2015 Nov 5
MALDI-TOF/TOF CID Study of Poly(1,4-dihydroxybenzene terephthalate) Fragmentation Reactions. Gies AP, Stow SM, McLean JA, Hercules DM Polymer 26195848 Polymer (Guildf) 2015 May 1
A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches. Janigro D, Iffland PH 2nd, Marchi N, Granata T Epilepsia 24001067 Epilepsia 2013 Sep
The relevance and potential roles of microphysiological systems in biology and medicine. Wikswo JP Experimental biology and medicine (Maywood, N.J.) 25187571 Exp Biol Med (Maywood) 2014 Sep
Note: A single-chamber tool for plasma activation and surface functionalization in microfabrication. Bowman AJ, Scherrer JR, Reiserer RS The Review of scientific instruments 26133881 Rev Sci Instrum 2015 Jun
Blood-brain barrier, bulk flow, and interstitial clearance in epilepsy. Marchi N, Banjara M, Janigro D Journal of neuroscience methods 26093166 J Neurosci Methods 2016 Feb 15
Systems-Wide High-Dimensional Data Acquisition and Informatics Using Structural Mass Spectrometry Strategies. Sherrod SD, McLean JA Clinical chemistry 26453699 Clin Chem 2016 Jan
Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer. May JC, Dodds JN, Kurulugama RT, Stafford GC, Fjeldsted JC, McLean JA The Analyst 26191544 Analyst 2015 Oct 21
Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes. Chun YW, Balikov DA, Feaster TK, Williams CH, Sheng CC, Lee JB, Boire TC, Neely MD, Bellan LM, Ess KC, Bowman AB, Sung HJ, Hong CC Biomaterials 26204225 Biomaterials 2015 Oct
Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode. McKenzie JR, Cognata AC, Davis AN, Wikswo JP, Cliffel DE Analytical chemistry 26125545 Anal Chem 2015 Aug 4
Engineering challenges for instrumenting and controlling integrated organ-on-chip systems. Wikswo JP, Block FE 3rd, Cliffel DE, Goodwin CR, Marasco CC, Markov DA, McLean DL, McLean JA, McKenzie JR, Reiserer RS, Samson PC, Schaffer DK, Seale KT, Sherrod SD IEEE transactions on bio-medical engineering 23380852 IEEE Trans Biomed Eng 2013 Mar
Cancer Stem Cells under Hypoxia as a Chemoresistance Factor in Breast and Brain. Crowder SW, Balikov DA, Hwang YS, Sung HJ Current pathobiology reports 24587979 Curr Pathobiol Rep 2014 Mar
Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status. Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB Metallomics : integrated biometal science 25599126 Metallomics 2015 Feb
Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures. Lizama-Manibusan BN, Klein S, McKenzie JR, Cliffel DE, McLaughlin B ACS chemical neuroscience 27504748 ACS Chem Neurosci 2016 Sep 21
Ultrathin Polymer Membranes with Patterned, Micrometric Pores for Organs-on-Chips. Pensabene V, Costa L, Terekhov AY, Gnecco JS, Wikswo JP, Hofmeister WH ACS applied materials & interfaces 27513606 ACS Appl Mater Interfaces 2016 Aug 31
Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge. May JC, McLean JA Annual review of analytical chemistry (Palo Alto, Calif.) 27306312 Annu Rev Anal Chem (Palo Alto Calif) 2016 Jun 12
Novel behavior of the chromatographic separation of linear and cyclic polymers. Montenegro-Burke JR, Bennett JM, McLean JA, Hercules DM Analytical and bioanalytical chemistry 26637218 Anal Bioanal Chem 2016 Jan
Untargeted Metabolomics Strategies-Challenges and Emerging Directions. Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA Journal of the American Society for Mass Spectrometry 27624161 J Am Soc Mass Spectrom 2016 Dec
Cationic Nanocylinders Promote Angiogenic Activities of Endothelial Cells. Lee JB, Balikov DA, Yang JW, Kim KS, Park HK, Kim JK, Kwon IK, Bellan LM, Sung HJ Polymers 29034114 Polymers (Basel) 2016 Jan
Transporters in drug-refractory epilepsy: clinical significance. Marchi N, Gonzalez-Martinez J, Nguyen MT, Granata T, Janigro D Clinical pharmacology and therapeutics 20019694 Clin Pharmacol Ther 2010 Jan
Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier. Janigro D Epilepsia 22612806 Epilepsia 2012 Jun
Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains. Ghosh C, Hossain M, Puvenna V, Martinez-Gonzalez J, Alexopolous A, Janigro D, Marchi N Epilepsia 23865846 Epilepsia 2013 Sep
Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells. Crowder SW, Prasai D, Rath R, Balikov DA, Bae H, Bolotin KI, Sung HJ Nanoscale 23592029 Nanoscale 2013 May 21
In Situ Crosslinkable Gelatin Hydrogels for Vasculogenic Induction and Delivery of Mesenchymal Stem Cells. Lee SH, Lee Y, Chun YW, Crowder SW, Young PP, Park KD, Sung HJ Advanced functional materials 26327818 Adv Funct Mater 2014 Nov 19
Pathophysiological implications of neurovascular P450 in brain disorders. Ghosh C, Hossain M, Solanki J, Dadas A, Marchi N, Janigro D Drug discovery today 27312874 Drug Discov Today 2016 Oct
Lipid profiling of polarized human monocyte-derived macrophages. Montenegro-Burke JR, Sutton JA, Rogers LM, Milne GL, McLean JA, Aronoff DM Prostaglandins & other lipid mediators 27871801 Prostaglandins Other Lipid Mediat 2016 Dec
S100B and S100B autoantibody as biomarkers for early detection of brain metastases in lung cancer. Choi H, Puvenna V, Brennan C, Mahmoud S, Wang XF, Phillips M, Janigro D, Mazzone P Translational lung cancer research 27652205 Transl Lung Cancer Res 2016 Aug
Improving the clinical management of traumatic brain injury through the pharmacokinetic modeling of peripheral blood biomarkers. Dadas A, Washington J, Marchi N, Janigro D Fluids and barriers of the CNS 27903281 Fluids Barriers CNS 2016 Nov 30
Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass spectrometer. May JC, Goodwin CR, Lareau NM, Leaptrot KL, Morris CB, Kurulugama RT, Mordehai A, Klein C, Barry W, Darland E, Overney G, Imatani K, Stafford GC, Fjeldsted JC, McLean JA Analytical chemistry 24446877 Anal Chem 2014 Feb 18
Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications. Lee SH, Gupta MK, Bang JB, Bae H, Sung HJ Advanced healthcare materials 25136729 Adv Healthc Mater 2013
Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia. Brown JA, Sherrod SD, Goodwin CR, Brewer B, Yang L, Garbett KA, Li D, McLean JA, Wikswo JP, Mirnics K Journal of neuroinflammation 25374324 J Neuroinflammation 2014 Nov 6
Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases. Hines KM, Ballard BR, Marshall DR, McLean JA Molecular bioSystems 25212505 Mol Biosyst 2014 Nov
Wavelet-based peak detection and a new charge inference procedure for MS/MS implemented in ProteoWizard's msConvert. French WR, Zimmerman LJ, Schilling B, Gibson BW, Miller CA, Townsend RR, Sherrod SD, Goodwin CR, McLean JA, Tabb DL Journal of proteome research 25411686 J Proteome Res 2015 Feb 6
Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. Wilkerson I, Laban J, Mitchell JM, Sheibani N, Alcendor DJ Journal of neuroinflammation 25573478 J Neuroinflammation 2015 Jan 9
Biology coming full circle: joining the whole and the parts. Wikswo JP, Porter AP Experimental biology and medicine (Maywood, N.J.) 25583953 Exp Biol Med (Maywood) 2015 Jan
Phosphorylation of serine 106 in Asef2 regulates cell migration and adhesion turnover. Evans JC, Hines KM, Forsythe JG, Erdogan B, Shi M, Hill S, Rose KL, McLean JA, Webb DJ Journal of proteome research 24874604 J Proteome Res 2014 Jul 3
What non-neuronal mechanisms should be studied to understand epileptic seizures? Janigro D, Walker MC Advances in experimental medicine and biology 25012382 Adv Exp Med Biol 2014
Ion mobility-mass spectrometry strategies for untargeted systems, synthetic, and chemical biology. May JC, Goodwin CR, McLean JA Current opinion in biotechnology 25462629 Curr Opin Biotechnol 2015 Feb
Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease. Popik W, Correa H, Khatua A, Aronoff DM, Alcendor DJ Journal of translational science 29977613 J Transl Sci 2019 Feb
Real-time cellular exometabolome analysis with a microfluidic-mass spectrometry platform. Marasco CC, Enders JR, Seale KT, McLean JA, Wikswo JP PloS one 25723555 PLoS One 2015
Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies. 2. Electrospray Spectra of 3-Ring and 4-Ring Isomers. Stow SM, Onifer TM, Forsythe JG, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM Analytical chemistry 25971782 Anal Chem 2015 Jun 16
Polymeric stent materials dysregulate macrophage and endothelial cell functions: implications for coronary artery stent. Wang X, Zachman AL, Chun YW, Shen FW, Hwang YS, Sung HJ International journal of cardiology 24820736 Int J Cardiol 2014 Jul 1
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. Boussadia B, Ghosh C, Plaud C, Pascussi JM, de Bock F, Rousset MC, Janigro D, Marchi N Neuroscience 25280786 Neuroscience 2014 Dec 5
Zika virus infection of cellular components of the blood-retinal barriers: implications for viral associated congenital ocular disease. Roach T, Alcendor DJ Journal of neuroinflammation 28253931 J Neuroinflammation 2017 Mar 3
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. Brown JA, Pensabene V, Markov DA, Allwardt V, Neely MD, Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, Wikswo JP Biomicrofluidics 26576206 Biomicrofluidics 2015 Sep
Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP Journal of neuroinflammation 27955696 J Neuroinflammation 2016 Dec 12
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models. Singh D, Deosarkar SP, Cadogan E, Flemington V, Bray A, Zhang J, Reiserer RS, Schaffer DK, Gerken GB, Britt CM, Werner EM, Gibbons FD, Kostrzewski T, Chambers CE, Davies EJ, Montoya AR, Fok JHL, Hughes D, Fabre K, Wagoner MP, Wikswo JP, Scott CW PLoS biology 35617197 PLoS Biol 2022 May
Elucidation of adhesion-dependent spontaneous apoptosis in macrophages using phase separated PEG/polyurethane films. Zachman AL, Page JM, Prabhakar G, Guelcher SA, Sung HJ Acta biomaterialia 23128157 Acta Biomater 2013 Feb
Does Systemic Inflammation Play a Role in Pediatric Psychosis? Falcone T, Carlton E, Lee C, Janigro M, Fazio V, Forcen FE, Franco K, Janigro D Clinical schizophrenia & related psychoses 23491967 Clin Schizophr Relat Psychoses 2015 Summer
Scaling and systems biology for integrating multiple organs-on-a-chip. Wikswo JP, Curtis EL, Eagleton ZE, Evans BC, Kole A, Hofmeister LH, Matloff WJ Lab on a chip 23828456 Lab Chip 2013 Sep 21
Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts. Shi M, Majumdar D, Gao Y, Brewer BM, Goodwin CR, McLean JA, Li D, Webb DJ Lab on a chip 23736663 Lab Chip 2013 Aug 7
Structural characterization of methylenedianiline regioisomers by ion mobility-mass spectrometry, tandem mass spectrometry, and computational strategies: I. Electrospray spectra of 2-ring isomers. Forsythe JG, Stow SM, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM Analytical chemistry 24678803 Anal Chem 2014 May 6
Neurovascular unit on a chip: implications for translational applications. Alcendor DJ, Block FE 3rd, Cliffel DE, Daniels JS, Ellacott KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B, McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP Stem cell research & therapy 24564885 Stem Cell Res Ther 2013
Femtosecond laser-patterned nanopore arrays for surface-mediated peptide treatment. Zachman AL, Hofmeister LH, Costa L, Boire TC, Hwang YS, Hofmeister WH, Sung HJ Nanomedicine : nanotechnology, biology, and medicine 24090768 Nanomedicine 2014 Jan
Phage-display-guided nanocarrier targeting to atheroprone vasculature. Hofmeister LH, Lee SH, Norlander AE, Montaniel KR, Chen W, Harrison DG, Sung HJ ACS nano 25768046 ACS Nano 2015
Variation in diffusion of gases through PDMS due to plasma surface treatment and storage conditions. Markov DA, Lillie EM, Garbett SP, McCawley LJ Biomedical microdevices 24065585 Biomed Microdevices 2014 Feb
Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells. Ghosh C, Hossain M, Solanki J, Najm IM, Marchi N, Janigro D Epilepsia 28199000 Epilepsia 2017 Apr
Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues. Karolak A, Markov DA, McCawley LJ, Rejniak KA Journal of the Royal Society, Interface 29367239 J R Soc Interface 2018 Jan
Zika Virus Infection of the Human Glomerular Cells: Implications for Viral Reservoirs and Renal Pathogenesis. Alcendor DJ The Journal of infectious diseases 28398522 J Infect Dis 2017 Jul 15
Inflammatory pathways of seizure disorders. Marchi N, Granata T, Janigro D Trends in neurosciences 24355813 Trends Neurosci 2014 Feb
Poised for success: implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients. McLaughlin B, Gidday JM Translational stroke research 24323191 Transl Stroke Res 2013 Feb
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy. Puvenna V, Engeler M, Banjara M, Brennan C, Schreiber P, Dadas A, Bahrami A, Solanki J, Bandyopadhyay A, Morris JK, Bernick C, Ghosh C, Rapp E, Bazarian JJ, Janigro D Brain research 26556772 Brain Res 2016 Jan 1
IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study. Wathen C, Janigro D Epilepsia 25099305 Epilepsia 2014 Aug
Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. Xu L, Kliman M, Forsythe JG, Korade Z, Hmelo AB, Porter NA, McLean JA Journal of the American Society for Mass Spectrometry 25822928 J Am Soc Mass Spectrom 2015 Jun
In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4(+) T Lymphocytes. Matta P, Sherrod SD, Marasco CC, Moore DJ, McLean JA, Weitkamp JH Journal of immunology (Baltimore, Md. : 1950) 28947540 J Immunol 2017 Nov 1
Determination of ion mobility collision cross sections for unresolved isomeric mixtures using tandem mass spectrometry and chemometric deconvolution. Harper B, Neumann EK, Stow SM, May JC, McLean JA, Solouki T Analytica chimica acta 27639144 Anal Chim Acta 2016 Oct 5
Emulator-based Bayesian inference on non-proportional scintillation models by compton-edge probing. Breitenmoser D, Cerutti F, Butterweck G, Kasprzak MM, Mayer S Nature communications 38012127 Nat Commun 2023 Nov 28
Biophysics and dynamics of natural and engineered stem cell microenvironments. Keung AJ, Healy KE, Kumar S, Schaffer DV Wiley interdisciplinary reviews. Systems biology and medicine 20836010 Wiley Interdiscip Rev Syst Biol Med 2010 Jan-Feb
Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs. Liu Y, Sakolish C, Chen Z, Phan DTT, Bender RHF, Hughes CCW, Rusyn I Toxicology 32980478 Toxicology 2020 Dec 1
Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Ma X, Duan Y, Tschudy-Seney B, Roll G, Behbahan IS, Ahuja TP, Tolstikov V, Wang C, McGee J, Khoobyari S, Nolta JA, Willenbring H, Zern MA Stem cells translational medicine 23681950 Stem Cells Transl Med 2013 Jun
Physiologically relevant organs on chips. Yum K, Hong SG, Healy KE, Lee LP Biotechnology journal 24357624 Biotechnol J 2014 Jan
Transplantable liver organoids made from only three ingredients. Willenbring H, Soto-Gutierrez A Cell stem cell 23910079 Cell Stem Cell 2013 Aug 1
In vitro cardiac tissue models: Current status and future prospects. Mathur A, Ma Z, Loskill P, Jeeawoody S, Healy KE Advanced drug delivery reviews 26428618 Adv Drug Deliv Rev 2016 Jan 15
WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue. Loskill P, Sezhian T, Tharp KM, Lee-Montiel FT, Jeeawoody S, Reese WM, Zushin PH, Stahl A, Healy KE Lab on a chip 28418430 Lab Chip 2017 May 2
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR Stem cell reports 25254341 Stem Cell Reports 2014 Aug 12
Human iPSC-based cardiac microphysiological system for drug screening applications. Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE Scientific reports 25748532 Sci Rep 2015 Mar 9
A therapy for liver failure found in the JNK yard. Willenbring H, Grompe M Cell 23582318 Cell 2013 Apr 11
Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE Tissue engineering. Part C, Methods 25333967 Tissue Eng Part C Methods 2015 May
A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis. Natividad-Diaz SL, Browne S, Jha AK, Ma Z, Hossainy S, Kurokawa YK, George SC, Healy KE Biomaterials 30583150 Biomaterials 2019 Feb
Mouse liver repopulation with hepatocytes generated from human fibroblasts. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S Nature 24572354 Nature 2014 Apr 3
Three-dimensional filamentous human diseased cardiac tissue model. Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE Biomaterials 24268663 Biomaterials 2014 Feb
Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE Nature biomedical engineering 31015724 Nat Biomed Eng 2018 Dec
Self-organizing human cardiac microchambers mediated by geometric confinement. Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE Nature communications 26172574 Nat Commun 2015 Jul 14
Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR Scientific reports 27095412 Sci Rep 2016 Apr 20
Aquaporin 9 induction in human iPSC-derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency. Laemmle A, Poms M, Hsu B, Borsuk M, Rüfenacht V, Robinson J, Sadowski MC, Nuoffer JM, Häberle J, Willenbring H Hepatology (Baltimore, Md.) 34786702 Hepatology 2022 Sep
Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE Stem cell research & therapy 24565415 Stem Cell Res Ther 2013
Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity. Wang C, Koo S, Park M, Vangelatos Z, Hoang P, Conklin BR, Grigoropoulos CP, Healy KE, Ma Z Advanced healthcare materials 32090507 Adv Healthc Mater 2020 Apr
Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes. Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S Biotechnology and bioengineering 29663322 Biotechnol Bioeng 2018 Aug
Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. Hoang P, Wang J, Conklin BR, Healy KE, Ma Z Nature protocols 29543795 Nat Protoc 2018 Apr
3D microtumors in vitro supported by perfused vascular networks. Sobrino A, Phan DT, Datta R, Wang X, Hachey SJ, Romero-López M, Gratton E, Lee AP, George SC, Hughes CC Scientific reports 27549930 Sci Rep 2016 Aug 23
Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms. Shirure VS, George SC Lab on a chip 28102869 Lab Chip 2017 Feb 14
Deep Learning for Drug Discovery and Cancer Research: Automated Analysis of Vascularization Images. Urban G, Bache KM, Phan D, Sobrino A, Shmakov AK, Hachey SJ, Hughes C, Baldi P IEEE/ACM transactions on computational biology and bioinformatics 29993583 IEEE/ACM Trans Comput Biol Bioinform 2019 May-Jun
An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW Lab on a chip 33605955 Lab Chip 2021 Apr 7
A three-dimensional in vitro model of tumor cell intravasation. Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC Integrative biology : quantitative biosciences from nano to macro 24763498 Integr Biol (Camb) 2014 Jun
Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Lee EK, Kurokawa YK, Tu R, George SC, Khine M Scientific reports 26139150 Sci Rep 2015 Jul 3
Automated detection and analysis of depolarization events in human cardiomyocytes using MaDEC. Szymanska AF, Heylman C, Datta R, Gratton E, Nenadic Z Computers in biology and medicine 27281718 Comput Biol Med 2016 Aug 1
Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems. Kurokawa YK, Yin RT, Shang MR, Shirure VS, Moya ML, George SC Tissue engineering. Part C, Methods 28622076 Tissue Eng Part C Methods 2017 Aug
A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. Hsu YH, Moya ML, Hughes CC, George SC, Lee AP Lab on a chip 23723013 Lab Chip 2013 Aug 7
Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components. Merna N, Fung KM, Wang JJ, King CR, Hansen KC, Christman KL, George SC Tissue engineering. Part A 25926101 Tissue Eng Part A 2015 Aug
Microfluidic device to attain high spatial and temporal control of oxygen. Lam SF, Shirure VS, Chu YE, Soetikno AG, George SC PloS one 30571786 PLoS One 2018
Microfluidic device to control interstitial flow-mediated homotypic and heterotypic cellular communication. Alonzo LF, Moya ML, Shirure VS, George SC Lab on a chip 26190172 Lab Chip 2015 Sep 7
Microfluidic device to culture 3D in vitro human capillary networks. Moya ML, Alonzo LF, George SC Methods in molecular biology (Clifton, N.J.) 24155229 Methods Mol Biol 2014
Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening. Kurokawa YK, George SC Advanced drug delivery reviews 26212156 Adv Drug Deliv Rev 2016 Jan 15
Fluorescence lifetime imaging of endogenous biomarker of oxidative stress. Datta R, Alfonso-García A, Cinco R, Gratton E Scientific reports 25993434 Sci Rep 2015 May 20
Nonsteady state oxygen transport in engineered tissue: implications for design. Ehsan SM, George SC Tissue engineering. Part A 23350630 Tissue Eng Part A 2013 Jun
Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes. Datta R, Heylman C, George SC, Gratton E Biomedical optics express 27231614 Biomed Opt Express 2016 May 1
A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. Phan DTT, Wang X, Craver BM, Sobrino A, Zhao D, Chen JC, Lee LYN, George SC, Lee AP, Hughes CCW Lab on a chip 28092382 Lab Chip 2017 Jan 31
Tissue Engineering the Vascular Tree. Traore MA, George SC Tissue engineering. Part B, Reviews 28799844 Tissue Eng Part B Rev 2017 Dec
Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Heylman C, Datta R, Sobrino A, George S, Gratton E PloS one 26695765 PLoS One 2015
Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity. Weng KC, Kurokawa YK, Hajek BS, Paladin JA, Shirure VS, George SC Tissue engineering. Part C, Methods 31797733 Tissue Eng Part C Methods 2020 Jan
3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels. Wang X, Phan DTT, George SC, Hughes CCW, Lee AP Methods in molecular biology (Clifton, N.J.) 28634954 Methods Mol Biol 2017
Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. Wang X, Phan DT, Sobrino A, George SC, Hughes CC, Lee AP Lab on a chip 26616908 Lab Chip 2016 Jan 21
Organ-on-a-chip model of vascularized human bone marrow niches. Glaser DE, Curtis MB, Sariano PA, Rollins ZA, Shergill BS, Anand A, Deely AM, Shirure VS, Anderson L, Lowen JM, Ng NR, Weilbaecher K, Link DC, George SC Biomaterials 34810038 Biomaterials 2022 Jan
Integrating in vitro organ-specific function with the microcirculation. Moya ML, George SC Current opinion in chemical engineering 24729953 Curr Opin Chem Eng 2014 Feb 1
An integrated in vitro model of perfused tumor and cardiac tissue. Moya M, Tran D, George SC Stem cell research & therapy 24565445 Stem Cell Res Ther 2013
A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening. Heylman C, Sobrino A, Shirure VS, Hughes CC, George SC Experimental biology and medicine (Maywood, N.J.) 24740872 Exp Biol Med (Maywood) 2014 Sep
Cancer-associated fibroblasts support vascular growth through mechanical force. Sewell-Loftin MK, Bayer SVH, Crist E, Hughes T, Joison SM, Longmore GD, George SC Scientific reports 28974764 Sci Rep 2017 Oct 3
Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis. Shirure VS, Lezia A, Tao A, Alonzo LF, George SC Angiogenesis 28608153 Angiogenesis 2017 Nov
Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface. Phan DT, Bender RHF, Andrejecsk JW, Sobrino A, Hachey SJ, George SC, Hughes CC Experimental biology and medicine (Maywood, N.J.) 28195514 Exp Biol Med (Maywood) 2017 Nov
Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Robertson C, Tran DD, George SC Stem cells (Dayton, Ohio) 23355363 Stem Cells 2013 May
The vascular niche in next generation microphysiological systems. Ewald ML, Chen YH, Lee AP, Hughes CCW Lab on a chip 34396383 Lab Chip 2021 Sep 7
Applications of tumor chip technology. Hachey SJ, Hughes CCW Lab on a chip 30156248 Lab Chip 2018 Sep 26
Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Shirure VS, Bi Y, Curtis MB, Lezia A, Goedegebuure MM, Goedegebuure SP, Aft R, Fields RC, George SC Lab on a chip 30393802 Lab Chip 2018 Dec 7
Executive summary of the 12th HHT international scientific conference. Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ Angiogenesis 29147802 Angiogenesis 2018 Feb
Vessel network formation in response to intermittent hypoxia is frequency dependent. Ehsan SM, George SC Journal of bioscience and bioengineering 25735591 J Biosci Bioeng 2015 Sep
Biomimetic on-a-chip platforms for studying cancer metastasis. Lee E, Song HG, Chen CS Current opinion in chemical engineering 27570735 Curr Opin Chem Eng 2016 Feb
Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK Nature communications 29247167 Nat Commun 2017 Dec 15
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. Qiu J, Nordling S, Vasavada HH, Butcher EC, Hirschi KK Cell reports 33264627 Cell Rep 2020 Dec 1
Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers. Chen AX, Chhabra A, Song HG, Fleming HE, Chen CS, Bhatia SN Advanced functional materials 33776613 Adv Funct Mater 2020 Nov 25
HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Vunjak-Novakovic G, Bhatia S, Chen C, Hirschi K Stem cell research & therapy 24565063 Stem Cell Res Ther 2013
Development of a new method for the isolation and culture of pulmonary arterial endothelial cells from rat pulmonary arteries. Peng G, Wen X, Shi Y, Jiang Y, Hu G, Zhou Y, Ran P Journal of vascular research 24192526 J Vasc Res 2013
Macrophages modulate engineered human tissues for enhanced vascularization and healing. Spiller KL, Freytes DO, Vunjak-Novakovic G Annals of biomedical engineering 25331098 Ann Biomed Eng 2015 Mar
3D culture models of tissues under tension. Eyckmans J, Chen CS Journal of cell science 27909243 J Cell Sci 2017 Jan 1
Tissue-Engineering for the Study of Cardiac Biomechanics. Ma SP, Vunjak-Novakovic G Journal of biomechanical engineering 26720588 J Biomech Eng 2016 Feb
Isolation of Murine Embryonic Hemogenic Endothelial Cells. Fang JS, Gritz EC, Marcelo KL, Hirschi KK Journal of visualized experiments : JoVE 27341393 J Vis Exp 2016 Jun 17
Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma. Villasante A, Sakaguchi K, Kim J, Cheung NK, Nakayama M, Parsa H, Okano T, Shimizu T, Vunjak-Novakovic G Theranostics 29158813 Theranostics 2017
Multifaceted Roles of Connexin 43 in Stem Cell Niches. Genet N, Bhatt N, Bourdieu A, Hirschi KK Current stem cell reports 29600160 Curr Stem Cell Rep 2018
Force-driven evolution of mesoscale structure in engineered 3D microtissues and the modulation of tissue stiffening. Zhao R, Chen CS, Reich DH Biomaterials 24630092 Biomaterials 2014 Jun
The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine. Martins AM, Vunjak-Novakovic G, Reis RL Stem cell reviews and reports 24425421 Stem Cell Rev Rep 2014 Apr
Cell and tissue engineering for liver disease. Bhatia SN, Underhill GH, Zaret KS, Fox IJ Science translational medicine 25031271 Sci Transl Med 2014 Jul 16
Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro. Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN Stem cell reports 25660406 Stem Cell Reports 2015 Mar 10
Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype. Ronaldson-Bouchard K, Yeager K, Teles D, Chen T, Ma S, Song L, Morikawa K, Wobma HM, Vasciaveo A, Ruiz EC, Yazawa M, Vunjak-Novakovic G Nature protocols 31492957 Nat Protoc 2019 Oct
The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. Chavkin NW, Sano S, Wang Y, Oshima K, Ogawa H, Horitani K, Sano M, MacLauchlan S, Nelson A, Setia K, Vippa T, Watanabe Y, Saucerman JJ, Hirschi KK, Gokce N, Walsh K Journal of the American Heart Association 34155901 J Am Heart Assoc 2021 Jul 6
Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. Baker BM, Trappmann B, Stapleton SC, Toro E, Chen CS Lab on a chip 23787488 Lab Chip 2013 Aug 21
Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice. Kam CY, Singh ID, Gonzalez DG, Matte-Martone C, Solá P, Solanas G, Bonjoch J, Marsh E, Hirschi KK, Greco V Cell 37167971 Cell 2023 May 25
A vascularized model of the human liver mimics regenerative responses. Chhabra A, Song HG, Grzelak KA, Polacheck WJ, Fleming HE, Chen CS, Bhatia SN Proceedings of the National Academy of Sciences of the United States of America 35763565 Proc Natl Acad Sci U S A 2022 Jul 12
Rational engineering of lung alveolar epithelium. Leiby KL, Yuan Y, Ng R, Raredon MSB, Adams TS, Baevova P, Greaney AM, Hirschi KK, Campbell SG, Kaminski N, Herzog EL, Niklason LE NPJ Regenerative medicine 37117221 NPJ Regen Med 2023 Apr 28
Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Genet N, Genet G, Chavkin NW, Paila U, Fang JS, Vasavada HH, Goldberg JS, Acharya BR, Bhatt NS, Baker K, McDonnell SP, Huba M, Sankaranarayanan D, Ma GZM, Eichmann A, Thomas JL, Ffrench-Constant C, Hirschi KK Cell reports 37043357 Cell Rep 2023 Apr 25
Portable bioreactor for perfusion and electrical stimulation of engineered cardiac tissue. Tandon N, Taubman A, Cimetta E, Saccenti L, Vunjak-Novakovic G Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 24111161 Annu Int Conf IEEE Eng Med Biol Soc 2013
Patterning vascular networks in vivo for tissue engineering applications. Chaturvedi RR, Stevens KR, Solorzano RD, Schwartz RE, Eyckmans J, Baranski JD, Stapleton SC, Bhatia SN, Chen CS Tissue engineering. Part C, Methods 25390971 Tissue Eng Part C Methods 2015 May
Myocardial tissue engineering: in vitro models. Vunjak Novakovic G, Eschenhagen T, Mummery C Cold Spring Harbor perspectives in medicine 24591534 Cold Spring Harb Perspect Med 2014 Mar 1
Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells. Cimetta E, Sirabella D, Yeager K, Davidson K, Simon J, Moon RT, Vunjak-Novakovic G Lab on a chip 23232509 Lab Chip 2013 Feb 7
Physical influences on stem cells. Vunjak-Novakovic G Stem cell research & therapy 24476419 Stem Cell Res Ther 2013 Dec 24
Natural cardiac extracellular matrix hydrogels for cultivation of human stem cell-derived cardiomyocytes. Freytes DO, O'Neill JD, Duan-Arnold Y, Wrona EA, Vunjak-Novakovic G Methods in molecular biology (Clifton, N.J.) 25070328 Methods Mol Biol 2014
Fluid shear stress threshold regulates angiogenic sprouting. Galie PA, Nguyen DH, Choi CK, Cohen DM, Janmey PA, Chen CS Proceedings of the National Academy of Sciences of the United States of America 24843171 Proc Natl Acad Sci U S A 2014 Jun 3
Forces and mechanotransduction in 3D vascular biology. Kutys ML, Chen CS Current opinion in cell biology 27209346 Curr Opin Cell Biol 2016 Oct
A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS Nature 29160307 Nature 2017 Dec 14
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development. Ronaldson-Bouchard K, Vunjak-Novakovic G Cell stem cell 29499151 Cell Stem Cell 2018 Mar 1
Tissue Engineering and Regenerative Medicine 2015: A Year in Review. Wobma H, Vunjak-Novakovic G Tissue engineering. Part B, Reviews 26714410 Tissue Eng Part B Rev 2016 Apr
Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue. Lee BW, Liu B, Pluchinsky A, Kim N, Eng G, Vunjak-Novakovic G Advanced healthcare materials 26865105 Adv Healthc Mater 2016 Apr 20
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes. Eng G, Lee BW, Protas L, Gagliardi M, Brown K, Kass RS, Keller G, Robinson RB, Vunjak-Novakovic G Nature communications 26785135 Nat Commun 2016 Jan 19
Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE Cell transplantation 28901188 Cell Transplant 2017 Aug
Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification. Logan DJ, Shan J, Bhatia SN, Carpenter AE Methods (San Diego, Calif.) 26687239 Methods 2016 Mar 1
FGF-dependent metabolic control of vascular development. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M Nature 28467822 Nature 2017 May 11
Tissue engineering of human hair follicles using a biomimetic developmental approach. Abaci HE, Coffman A, Doucet Y, Chen J, Jacków J, Wang E, Guo Z, Shin JU, Jahoda CA, Christiano AM Nature communications 30546011 Nat Commun 2018 Dec 13
Biomechanical regulation of drug sensitivity in an engineered model of human tumor. Marturano-Kruik A, Villasante A, Yaeger K, Ambati SR, Chramiec A, Raimondi MT, Vunjak-Novakovic G Biomaterials 29040875 Biomaterials 2018 Jan
Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues. Song HG, Lammers A, Sundaram S, Rubio L, Chen AX, Li L, Eyckmans J, Bhatia SN, Chen CS Advanced functional materials 33613149 Adv Funct Mater 2020 Nov 25
Endothelial Cell Development and Its Application to Regenerative Medicine. Qiu J, Hirschi KK Circulation research 31518171 Circ Res 2019 Aug 2
Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells. Nelson EA, Qiu J, Chavkin NW, Hirschi KK Journal of visualized experiments : JoVE 33871448 J Vis Exp 2021 Mar 31
Bioengineering heart tissue for in vitro testing. Cimetta E, Godier-Furnémont A, Vunjak-Novakovic G Current opinion in biotechnology 23932513 Curr Opin Biotechnol 2013 Oct
Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. Nguyen DH, Stapleton SC, Yang MT, Cha SS, Choi CK, Galie PA, Chen CS Proceedings of the National Academy of Sciences of the United States of America 23569284 Proc Natl Acad Sci U S A 2013 Apr 23
Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling. Cimetta E, Cannizzaro C, James R, Biechele T, Moon RT, Elvassore N, Vunjak-Novakovic G Lab on a chip 20936235 Lab Chip 2010 Dec 7
Tissue engineering of the heart: An evolving paradigm. Vunjak-Novakovic G The Journal of thoracic and cardiovascular surgery 27692954 J Thorac Cardiovasc Surg 2017 Mar
milliPillar: A Platform for the Generation and Real-Time Assessment of Human Engineered Cardiac Tissues. Tamargo MA, Nash TR, Fleischer S, Kim Y, Vila OF, Yeager K, Summers M, Zhao Y, Lock R, Chavez M, Costa T, Vunjak-Novakovic G ACS biomaterials science & engineering 34668692 ACS Biomater Sci Eng 2021 Nov 8
Endothelial Cell Differentiation and Hemogenic Specification. Aragon JW, Hirschi KK Cold Spring Harbor perspectives in medicine 35193895 Cold Spring Harb Perspect Med 2022 Jul 29
Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes. Genet N, Hirschi KK Regenerative medicine 34498495 Regen Med 2021 Sep
Induced pluripotent stem cells for regenerative medicine. Hirschi KK, Li S, Roy K Annual review of biomedical engineering 24905879 Annu Rev Biomed Eng 2014 Jul 11
The magic touch: endothelial cells muscle-up adipose. Martin KA, Hirschi KK Circulation research 25301822 Circ Res 2014 Oct 10
A DNA-based molecular probe for optically reporting cellular traction forces. Blakely BL, Dumelin CE, Trappmann B, McGregor LM, Choi CK, Anthony PC, Duesterberg VK, Baker BM, Block SM, Liu DR, Chen CS Nature methods 25306545 Nat Methods 2014 Dec
Bioengineered tumors. Villasante A, Vunjak-Novakovic G Bioengineered 25616977 Bioengineered 2015
Long-range force transmission in fibrous matrices enabled by tension-driven alignment of fibers. Wang H, Abhilash AS, Chen CS, Wells RG, Shenoy VB Biophysical journal 25468338 Biophys J 2014 Dec 2
In vitro Models of Ischemia-Reperfusion Injury. Chen T, Vunjak-Novakovic G Regenerative engineering and translational medicine 30393757 Regen Eng Transl Med 2018 Sep
A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling. Nguyen DT, Lee E, Alimperti S, Norgard RJ, Wong A, Lee JJ, Eyckmans J, Stanger BZ, Chen CS Science advances 31489365 Sci Adv 2019 Aug
Human bone perivascular niche-on-a-chip for studying metastatic colonization. Marturano-Kruik A, Nava MM, Yeager K, Chramiec A, Hao L, Robinson S, Guo E, Raimondi MT, Vunjak-Novakovic G Proceedings of the National Academy of Sciences of the United States of America 29363599 Proc Natl Acad Sci U S A 2018 Feb 6
Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Ronaldson-Bouchard K, Ma SP, Yeager K, Chen T, Song L, Sirabella D, Morikawa K, Teles D, Yazawa M, Vunjak-Novakovic G Nature 29618819 Nature 2018 Apr
"The state of the heart": Recent advances in engineering human cardiac tissue from pluripotent stem cells. Sirabella D, Cimetta E, Vunjak-Novakovic G Experimental biology and medicine (Maywood, N.J.) 26069271 Exp Biol Med (Maywood) 2015 Aug
Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors. Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN Cancer research 26122846 Cancer Res 2015 Aug 15
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Shlomai A, Schwartz RE, Ramanan V, Bhatta A, de Jong YP, Bhatia SN, Rice CM Proceedings of the National Academy of Sciences of the United States of America 25092305 Proc Natl Acad Sci U S A 2014 Aug 19
Label-free evaluation of angiogenic sprouting in microengineered devices using ultrahigh-resolution optical coherence microscopy. Li F, Xu T, Nguyen DH, Huang X, Chen CS, Zhou C Journal of biomedical optics 24395588 J Biomed Opt 2014 Jan
Non-destructive vacuum-assisted measurement of lung elastic modulus. Chen J, Mir M, Pinezich MR, O'Neill JD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G, Huang SXL, Kim J Acta biomaterialia 34192570 Acta Biomater 2021 Sep 1
Laminar flow downregulates Notch activity to promote lymphatic sprouting. Choi D, Park E, Jung E, Seong YJ, Yoo J, Lee E, Hong M, Lee S, Ishida H, Burford J, Peti-Peterdi J, Adams RH, Srikanth S, Gwack Y, Chen CS, Vogel HJ, Koh CJ, Wong AK, Hong YK The Journal of clinical investigation 28263185 J Clin Invest 2017 Apr 3
Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE Cell reports 28009297 Cell Rep 2016 Dec 20
(*) Extracellular Vesicles and Their Versatile Roles in Tissue Engineering. Jay SM, Vunjak-Novakovic G Tissue engineering. Part A 28649910 Tissue Eng Part A 2017 Nov
Bioengineered Models of Solid Human Tumors for Cancer Research. Marturano-Kruik A, Villasante A, Vunjak-Novakovic G Methods in molecular biology (Clifton, N.J.) 27115504 Methods Mol Biol 2016
Next generation human skin constructs as advanced tools for drug development. Abaci HE, Guo Z, Doucet Y, Jacków J, Christiano A Experimental biology and medicine (Maywood, N.J.) 28592171 Exp Biol Med (Maywood) 2017 Nov
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues. Feric NT, Radisic M Advanced drug delivery reviews 25956564 Adv Drug Deliv Rev 2016 Jan 15
Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK Circulation 38126211 Circulation 2024 Mar 19
MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis. Wu Y, Paila U, Genet G, Hirschi KK Developmental cell 37295435 Dev Cell 2023 Jul 24
Bioreactor engineering of stem cell environments. Tandon N, Marolt D, Cimetta E, Vunjak-Novakovic G Biotechnology advances 23531529 Biotechnol Adv 2013 Nov 15
Vascular endothelial cell specification in health and disease. Marziano C, Genet G, Hirschi KK Angiogenesis 33844116 Angiogenesis 2021 May
Microscale technologies for regulating human stem cell differentiation. Cimetta E, Vunjak-Novakovic G Experimental biology and medicine (Maywood, N.J.) 24737735 Exp Biol Med (Maywood) 2014 Sep
Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells. Goligorsky MS, Hirschi K Advances in pharmacology (San Diego, Calif.) 27451101 Adv Pharmacol 2016
Microfabricated blood vessels for modeling the vascular transport barrier. Polacheck WJ, Kutys ML, Tefft JB, Chen CS Nature protocols 30953042 Nat Protoc 2019 May
The molecular basis of endothelial cell plasticity. Dejana E, Hirschi KK, Simons M Nature communications 28181491 Nat Commun 2017 Feb 9
Isolation of Highly Purified and Viable Retinal Endothelial Cells. Chavkin NW, Walsh K, Hirschi KK Journal of vascular research 33022674 J Vasc Res 2021
Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety. Chramiec A, Teles D, Yeager K, Marturano-Kruik A, Pak J, Chen T, Hao L, Wang M, Lock R, Tavakol DN, Lee MB, Kim J, Ronaldson-Bouchard K, Vunjak-Novakovic G Lab on a chip 32955072 Lab Chip 2020 Nov 24
Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Liu B, Lee BW, Nakanishi K, Villasante A, Williamson R, Metz J, Kim J, Kanai M, Bi L, Brown K, Di Paolo G, Homma S, Sims PA, Topkara VK, Vunjak-Novakovic G Nature biomedical engineering 30271672 Nat Biomed Eng 2018 May
Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS Proceedings of the National Academy of Sciences of the United States of America 28765370 Proc Natl Acad Sci U S A 2017 Aug 15
Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. McCurley A, Alimperti S, Campos-Bilderback SB, Sandoval RM, Calvino JE, Reynolds TL, Quigley C, Mugford JW, Polacheck WJ, Gomez IG, Dovey J, Marsh G, Huang A, Qian F, Weinreb PH, Dolinski BM, Moore S, Duffield JS, Chen CS, Molitoris BA, Violette SM, Crackower MA Journal of the American Society of Nephrology : JASN 28062569 J Am Soc Nephrol 2017 Jun
Modeling tumor microenvironments using custom-designed biomaterial scaffolds. Liu Z, Vunjak-Novakovic G Current opinion in chemical engineering 27152253 Curr Opin Chem Eng 2016 Feb
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR Arteriosclerosis, thrombosis, and vascular biology 27834690 Arterioscler Thromb Vasc Biol 2017 Feb
Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Li CY, Stevens KR, Schwartz RE, Alejandro BS, Huang JH, Bhatia SN Tissue engineering. Part A 24498910 Tissue Eng Part A 2014 Aug
Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK Cell reports 25310984 Cell Rep 2014 Oct 23
Bioengineering methods for myocardial regeneration. Parsa H, Ronaldson K, Vunjak-Novakovic G Advanced drug delivery reviews 26150344 Adv Drug Deliv Rev 2016 Jan 15
HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, Linke WA, Chen CS, Seidman JG, Seidman CE Science (New York, N.Y.) 26315439 Science 2015 Aug 28
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model. Villasante A, Marturano-Kruik A, Ambati SR, Liu Z, Godier-Furnemont A, Parsa H, Lee BW, Moore MA, Vunjak-Novakovic G Theranostics 27279906 Theranostics 2016
Engineering a perfusable 3D human liver platform from iPS cells. Schepers A, Li C, Chhabra A, Seney BT, Bhatia S Lab on a chip 27296616 Lab Chip 2016 Jul 5
High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro. Shan J, Logan DJ, Root DE, Carpenter AE, Bhatia SN Journal of biomolecular screening 27650791 J Biomol Screen 2016 Oct
Endothelial cell cycle state determines propensity for arterial-venous fate. Chavkin NW, Genet G, Poulet M, Jeffery ED, Marziano C, Genet N, Vasavada H, Nelson EA, Acharya BR, Kour A, Aragon J, McDonnell SP, Huba M, Sheynkman GM, Walsh K, Hirschi KK Nature communications 36202789 Nat Commun 2022 Oct 6
How multi-organ microdevices can help foster drug development. Esch MB, Smith AS, Prot JM, Oleaga C, Hickman JJ, Shuler ML Advanced drug delivery reviews 24412641 Adv Drug Deliv Rev 2014 Apr
Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury. Esch MB, Mahler GJ, Stokol T, Shuler ML Lab on a chip 24970651 Lab Chip 2014 Aug 21
A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro. Smith AS, Long CJ, Pirozzi K, Najjar S, McAleer C, Vandenburgh HH, Hickman JJ Journal of biotechnology 24909944 J Biotechnol 2014 Sep 20
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Chen HJ, Sun J, Huang Z, Hou H Jr, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümüş ZH, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin SM Nature biotechnology 26006007 Nat Biotechnol 2015 Jun
A phenotypic in vitro model for the main determinants of human whole heart function. Stancescu M, Molnar P, McAleer CW, McLamb W, Long CJ, Oleaga C, Prot JM, Hickman JJ Biomaterials 25978005 Biomaterials 2015 Aug
Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization. Chen HJ, Shuler ML Methods in molecular biology (Clifton, N.J.) 30542993 Methods Mol Biol 2019
Charge Relaxation Dynamics of an Electrolytic Nanocapacitor. Thakore V, Hickman JJ The journal of physical chemistry. C, Nanomaterials and interfaces 25678941 J Phys Chem C Nanomater Interfaces 2015 Jan 29
A recellularized human colon model identifies cancer driver genes. Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML Nature biotechnology 27398792 Nat Biotechnol 2016 Aug
Microphysiological systems and low-cost microfluidic platform with analytics. Smith AS, Long CJ, Berry BJ, McAleer C, Stancescu M, Molnar P, Miller PG, Esch MB, Prot JM, Hickman JJ, Shuler ML Stem cell research & therapy 24565109 Stem Cell Res Ther 2013
A functional long-term 2D serum-free human hepatic in vitro system for drug evaluation. Oleaga C, Bridges LR, Persaud K, McAleer CW, Long CJ, Hickman JJ Biotechnology progress 32829524 Biotechnol Prog 2021 Jan
A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Chen HJ, Miller P, Shuler ML Lab on a chip 29881844 Lab Chip 2018 Jul 10
Self-contained, low-cost Body-on-a-Chip systems for drug development. Wang YI, Oleaga C, Long CJ, Esch MB, McAleer CW, Miller PG, Hickman JJ, Shuler ML Experimental biology and medicine (Maywood, N.J.) 29065797 Exp Biol Med (Maywood) 2017 Nov
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Abaci HE, Shuler ML Integrative biology : quantitative biosciences from nano to macro 25739725 Integr Biol (Camb) 2015 Apr
Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure. Sung JH, Srinivasan B, Esch MB, McLamb WT, Bernabini C, Shuler ML, Hickman JJ Experimental biology and medicine (Maywood, N.J.) 24951471 Exp Biol Med (Maywood) 2014 Sep
Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system. Oleaga C, Riu A, Rothemund S, Lavado A, McAleer CW, Long CJ, Persaud K, Narasimhan NS, Tran M, Roles J, Carmona-Moran CA, Sasserath T, Elbrecht DH, Kumanchik L, Bridges LR, Martin C, Schnepper MT, Ekman G, Jackson M, Wang YI, Note R, Langer J, Teissier S, Hickman JJ Biomaterials 30130706 Biomaterials 2018 Nov
TEER measurement techniques for in vitro barrier model systems. Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ Journal of laboratory automation 25586998 J Lab Autom 2015 Apr
Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems. Berry BJ, Akanda N, Smith AS, Long CJ, Schnepper MT, Guo X, Hickman JJ Biotechnology progress 26317319 Biotechnol Prog 2015 Nov-Dec
Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs. Oleaga C, Bernabini C, Smith AS, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, Ekman G, Esch MB, Langer J, Ouedraogo G, Cotovio J, Breton L, Shuler ML, Hickman JJ Scientific reports 26837601 Sci Rep 2016 Feb 3
Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening. Wang YI, Abaci HE, Shuler ML Biotechnology and bioengineering 27399645 Biotechnol Bioeng 2017 Jan
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. Esch MB, Prot JM, Wang YI, Miller P, Llamas-Vidales JR, Naughton BA, Applegate DR, Shuler ML Lab on a chip 25857666 Lab Chip 2015 May 21
Rat hepatocyte culture model of macrosteatosis: effect of macrosteatosis induction and reversal on viability and liver-specific function. Nativ NI, Yarmush G, Chen A, Dong D, Henry SD, Guarrera JV, Klein KM, Maguire T, Schloss R, Berthiaume F, Yarmush ML Journal of hepatology 23872604 J Hepatol 2013 Dec
Microphysiological modeling of the reproductive tract: a fertile endeavor. Eddie SL, Kim JJ, Woodruff TK, Burdette JE Experimental biology and medicine (Maywood, N.J.) 24737736 Exp Biol Med (Maywood) 2014 Sep
Ovarian cancer in endometriosis: clinical and molecular aspects. Lyttle B, Bernardi L, Pavone ME Minerva ginecologica 24848074 Minerva Ginecol 2014 Apr
Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment. Laronda MM, Burdette JE, Kim J, Woodruff TK Stem cell research & therapy 24565375 Stem Cell Res Ther 2013
Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs). Itoh M, Umegaki-Arao N, Guo Z, Liu L, Higgins CA, Christiano AM PloS one 24147053 PLoS One 2013
Melanin Transfer in Human 3D Skin Equivalents Generated Exclusively from Induced Pluripotent Stem Cells. Gledhill K, Guo Z, Umegaki-Arao N, Higgins CA, Itoh M, Christiano AM PloS one 26308443 PLoS One 2015
Challenges and promises in modeling dermatologic disorders with bioengineered skin. Eungdamrong NJ, Higgins C, Guo Z, Lee WH, Gillette B, Sia S, Christiano AM Experimental biology and medicine (Maywood, N.J.) 24951469 Exp Biol Med (Maywood) 2014 Sep
Building a microphysiological skin model from induced pluripotent stem cells. Guo Z, Higgins CA, Gillette BM, Itoh M, Umegaki N, Gledhill K, Sia SK, Christiano AM Stem cell research & therapy 24564920 Stem Cell Res Ther 2013
Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells. Abaci HE, Guo Z, Coffman A, Gillette B, Lee WH, Sia SK, Christiano AM Advanced healthcare materials 27333469 Adv Healthc Mater 2016 Jul
Engineering human skin model innervated with itch sensory neuron-like cells differentiated from induced pluripotent stem cells. Guo Z, Tong CK, Jacków J, Doucet YS, Abaci HE, Zeng W, Hansen C, Hayashi R, DeLorenzo D, Rami A, Pappalardo A, Lumpkin EA, Christiano AM Bioengineering & translational medicine 35111948 Bioeng Transl Med 2022 Jan
Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use. Nichols JE, Niles JA, Vega SP, Argueta LB, Eastaway A, Cortiella J Experimental biology and medicine (Maywood, N.J.) 24962174 Exp Biol Med (Maywood) 2014 Sep
Production and assessment of decellularized pig and human lung scaffolds. Nichols JE, Niles J, Riddle M, Vargas G, Schilagard T, Ma L, Edward K, La Francesca S, Sakamoto J, Vega S, Ogadegbe M, Mlcak R, Deyo D, Woodson L, McQuitty C, Lick S, Beckles D, Melo E, Cortiella J Tissue engineering. Part A 23638920 Tissue Eng Part A 2013 Sep
Novel in vitro respiratory models to study lung development, physiology, pathology and toxicology. Nichols JE, Niles JA, Vega SP, Cortiella J Stem cell research & therapy 24565038 Stem Cell Res Ther 2013
Platforms to test the temporospatial capabilities of carrier systems in delivering growth factors to benefit vascular bioengineering. Argueta LB, Niles JA, Sakamoto J, Liu X, Vega SP, Frank L, Paessler M, Cortiella J, Nichols JE Nanomedicine : nanotechnology, biology, and medicine 34147665 Nanomedicine 2021 Aug
Production and transplantation of bioengineered lung into a large-animal model. Nichols JE, La Francesca S, Niles JA, Vega SP, Argueta LB, Frank L, Christiani DC, Pyles RB, Himes BE, Zhang R, Li S, Sakamoto J, Rhudy J, Hendricks G, Begarani F, Liu X, Patrikeev I, Pal R, Usheva E, Vargas G, Miller A, Woodson L, Wacher A, Grimaldo M, Weaver D, Mlcak R, Cortiella J Science translational medicine 30068570 Sci Transl Med 2018 Aug 1
The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M Annual review of physiology 28192061 Annu Rev Physiol 2017 Feb 10
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Yin J, Tse CM, Avula LR, Singh V, Foulke-Abel J, de Jonge HR, Donowitz M Cellular and molecular gastroenterology and hepatology 29930980 Cell Mol Gastroenterol Hepatol 2018
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip. Yin J, Sunuwar L, Kasendra M, Yu H, Tse CM, Talbot CC Jr, Boronina T, Cole R, Karalis K, Donowitz M American journal of physiology. Gastrointestinal and liver physiology 33074011 Am J Physiol Gastrointest Liver Physiol 2021 Mar 1
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O Cellular and molecular gastroenterology and hepatology 26855967 Cell Mol Gastroenterol Hepatol 2016 Jan 1
Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M The Journal of biological chemistry 26677228 J Biol Chem 2016 Feb 19
Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling. Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M American journal of physiology. Cell physiology 24760985 Am J Physiol Cell Physiol 2014 Jul 1
Human enteroids: preclinical models of non-inflammatory diarrhea. Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M Stem cell research & therapy 24564938 Stem Cell Res Ther 2013
Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK Cellular and molecular gastroenterology and hepatology 29675450 Cell Mol Gastroenterol Hepatol 2018 Mar
Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M Experimental biology and medicine (Maywood, N.J.) 24719375 Exp Biol Med (Maywood) 2014 Sep
A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK Proceedings of the National Academy of Sciences of the United States of America 28069942 Proc Natl Acad Sci U S A 2017 Jan 24
Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK Methods in molecular biology (Clifton, N.J.) 28361480 Methods Mol Biol 2019
Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 24184676 Clin Gastroenterol Hepatol 2014 Jan
cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity. Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M Cellular and molecular gastroenterology and hepatology 30659943 Cell Mol Gastroenterol Hepatol 2019
Gastrointestinal microphysiological systems. Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK Experimental biology and medicine (Maywood, N.J.) 28534432 Exp Biol Med (Maywood) 2017 Oct
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK Journal of virology 26446608 J Virol 2016 Jan 1
21st Century Cell Culture for 21st Century Toxicology. Pamies D, Hartung T Chemical research in toxicology 28092941 Chem Res Toxicol 2017 Jan 17
Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity. Pamies D, Wiersma D, Katt ME, Zhao L, Burtscher J, Harris G, Smirnova L, Searson PC, Hartung T, Hogberg HT Neurobiology of disease 35398340 Neurobiol Dis 2022 Jul
Mapping the human toxome by systems toxicology. Bouhifd M, Hogberg HT, Kleensang A, Maertens A, Zhao L, Hartung T Basic & clinical pharmacology & toxicology 24443875 Basic Clin Pharmacol Toxicol 2014 Jul
Biological and medical applications of a brain-on-a-chip. Pamies D, Hartung T, Hogberg HT Experimental biology and medicine (Maywood, N.J.) 24912505 Exp Biol Med (Maywood) 2014 Sep
Mechanistic validation. Hartung T, Hoffmann S, Stephens M ALTEX 23665802 ALTEX 2013
Look back in anger - what clinical studies tell us about preclinical work. Hartung T ALTEX 23861075 ALTEX 2013
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Axelstad M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks MF, Ylikomi T, Fritsche E Archives of toxicology 25618548 Arch Toxicol 2015 Feb
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. Alépée N, Bahinski A, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG ALTEX 25027500 ALTEX 2014
3D Differentiation of LUHMES Cell Line to Study Recovery and Delayed Neurotoxic Effects. Harris G, Hogberg H, Hartung T, Smirnova L Current protocols in toxicology 28777440 Curr Protoc Toxicol 2017 Aug 4
A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity. Pamies D, Barreras P, Block K, Makri G, Kumar A, Wiersma D, Smirnova L, Zang C, Bressler J, Christian KM, Harris G, Ming GL, Berlinicke CJ, Kyro K, Song H, Pardo CA, Hartung T, Hogberg HT ALTEX 27883356 ALTEX 2017
A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis. Smirnova L, Harris G, Delp J, Valadares M, Pamies D, Hogberg HT, Waldmann T, Leist M, Hartung T Archives of toxicology 26647301 Arch Toxicol 2016 Nov
Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres. Abreu CM, Gama L, Krasemann S, Chesnut M, Odwin-Dacosta S, Hogberg HT, Hartung T, Pamies D Frontiers in microbiology 30619100 Front Microbiol 2018
Toward a 3D model of human brain development for studying gene/environment interactions. Hogberg HT, Bressler J, Christian KM, Harris G, Makri G, O'Driscoll C, Pamies D, Smirnova L, Wen Z, Hartung T Stem cell research & therapy 24564953 Stem Cell Res Ther 2013
Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. Coulter JB, O'Driscoll CM, Bressler JP The Journal of biological chemistry 23940045 J Biol Chem 2013 Oct 4
Rotenone exerts developmental neurotoxicity in a human brain spheroid model. Pamies D, Block K, Lau P, Gribaldo L, Pardo CA, Barreras P, Smirnova L, Wiersma D, Zhao L, Harris G, Hartung T, Hogberg HT Toxicology and applied pharmacology 29428530 Toxicol Appl Pharmacol 2018 Sep 1
3S - Systematic, systemic, and systems biology and toxicology. Smirnova L, Kleinstreuer N, Corvi R, Levchenko A, Fitzpatrick SC, Hartung T ALTEX 29677694 ALTEX 2018
Perspectives on In Vitro to In Vivo Extrapolations. Hartung T Applied in vitro toxicology 31890748 Appl In Vitro Toxicol 2018 Dec 1
3D - a new dimension of in vitro research. Hartung T Advanced drug delivery reviews 24721291 Adv Drug Deliv Rev 2014 Apr
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Eicher AK, Kechele DO, Sundaram N, Berns HM, Poling HM, Haines LE, Sanchez JG, Kishimoto K, Krishnamurthy M, Han L, Zorn AM, Helmrath MA, Wells JM Cell stem cell 34856121 Cell Stem Cell 2022 Jan 6
An in vivo model of human small intestine using pluripotent stem cells. Watson CL, Mahe MM, Múnera J, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y, Grabowski G, Finkbeiner SR, Spence JR, Shroyer NF, Wells JM, Helmrath MA Nature medicine 25326803 Nat Med 2014 Nov
Developmental biology. Regional identity of gut stem cells--one gene to rule them all. Wells JM Nature reviews. Gastroenterology & hepatology 25645971 Nat Rev Gastroenterol Hepatol 2015 Mar
Building additional complexity to in vitro-derived intestinal tissues. Brugmann SA, Wells JM Stem cell research & therapy 24565179 Stem Cell Res Ther 2013
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM Nature medicine 27869805 Nat Med 2017 Jan
Generating human intestinal tissues from pluripotent stem cells to study development and disease. Sinagoga KL, Wells JM The EMBO journal 25792515 EMBO J 2015 May 5
A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells. Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH American journal of physiology. Gastrointestinal and liver physiology 23928185 Am J Physiol Gastrointest Liver Physiol 2013 Oct 15
Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Vega ME, Giroux V, Natsuizaka M, Liu M, Klein-Szanto AJ, Stairs DB, Nakagawa H, Wang KK, Wang TC, Lynch JP, Rustgi AK Cell cycle (Georgetown, Tex.) 25558829 Cell Cycle 2014
Mechanisms of Barrett's oesophagus: intestinal differentiation, stem cells, and tissue models. Nakagawa H, Whelan K, Lynch JP Best practice & research. Clinical gastroenterology 25743452 Best Pract Res Clin Gastroenterol 2015 Feb
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. Hartman KG, Bortner JD, Falk GW, Yu J, Martín MG, Rustgi AK, Lynch JP Stem cell research & therapy 24564965 Stem Cell Res Ther 2013
Culturing adult stem cells from mouse small intestinal crypts. Hamilton KE, Crissey MA, Lynch JP, Rustgi AK Cold Spring Harbor protocols 25834260 Cold Spring Harb Protoc 2015 Apr 1
Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins. Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA Infection and immunity 27481254 Infect Immun 2016 Oct
Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. Kong J, Whelan KA, Laczkó D, Dang B, Caro Monroig A, Soroush A, Falcone J, Amaravadi RK, Rustgi AK, Ginsberg GG, Falk GW, Nakagawa H, Lynch JP Molecular carcinogenesis 26373456 Mol Carcinog 2016 Nov
Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia. Kong J, Sai H, Crissey MA, Jhala N, Falk GW, Ginsberg GG, Abrams JA, Nakagawa H, Wang K, Rustgi AK, Wang TC, Lynch JP Oncotarget 26460825 Oncotarget 2015 Oct 20
Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research. Abrams JA, Appelman HD, Beer DG, Berry LD, Chak A, Falk GW, Fitzgerald RC, Ginsberg GG, Grady WM, Joshi BP, Lynch JP, Markowitz S, Richmond ES, Rustgi AK, Seibel EJ, Shaheen NJ, Shyr Y, Umar A, Wang KK, Wang TC, Wang TD, Yassin R Gastroenterology 24768332 Gastroenterology 2014 Jun
Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. Hartman KG, Bortner JD Jr, Falk GW, Ginsberg GG, Jhala N, Yu J, Martín MG, Rustgi AK, Lynch JP Experimental biology and medicine (Maywood, N.J.) 24781339 Exp Biol Med (Maywood) 2014 Sep
Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution. Lin H, Cheng AW, Alexander PG, Beck AM, Tuan RS Tissue engineering. Part A 24575844 Tissue Eng Part A 2014 Sep
Distributed and Lumped Parameter Models for the Characterization of High Throughput Bioreactors. Iannetti L, D'Urso G, Conoscenti G, Cutrì E, Tuan RS, Raimondi MT, Gottardi R, Zunino P PloS one 27669413 PLoS One 2016
Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Jiang Y, Cai Y, Zhang W, Yin Z, Hu C, Tong T, Lu P, Zhang S, Neculai D, Tuan RS, Ouyang HW Stem cells translational medicine 27130221 Stem Cells Transl Med 2016 Jun
Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix. Yang G, Rothrauff BB, Lin H, Gottardi R, Alexander PG, Tuan RS Biomaterials 24044998 Biomaterials 2013 Dec
Regenerative medicine in 2012: the coming of age of musculoskeletal tissue engineering. Tuan RS Nature reviews. Rheumatology 23321611 Nat Rev Rheumatol 2013 Feb
Origin and function of cartilage stem/progenitor cells in osteoarthritis. Jiang Y, Tuan RS Nature reviews. Rheumatology 25536487 Nat Rev Rheumatol 2015 Apr
A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads. Capuana E, Marino D, Di Gesù R, La Carrubba V, Brucato V, Tuan RS, Gottardi R Cells, tissues, organs 34261061 Cells Tissues Organs 2022
A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit. Chiesa I, Di Gesù R, Overholt KJ, Gottardi R Methods in molecular biology (Clifton, N.J.) 34520018 Methods Mol Biol 2022
Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering. Sun AX, Lin H, Beck AM, Kilroy EJ, Tuan RS Frontiers in bioengineering and biotechnology 26347860 Front Bioeng Biotechnol 2015
Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β. Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS Molecular pharmaceutics 24830762 Mol Pharm 2014 Jul 7
Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. Lozito TP, Alexander PG, Lin H, Gottardi R, Cheng AW, Tuan RS Stem cell research & therapy 24564995 Stem Cell Res Ther 2013
Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor. Diederichs S, Tuan RS Stem cells and development 24625206 Stem Cells Dev 2014 Jul 15
Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. Alexander PG, Gottardi R, Lin H, Lozito TP, Tuan RS Experimental biology and medicine (Maywood, N.J.) 24994814 Exp Biol Med (Maywood) 2014 Sep
Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies. Hofer HR, Tuan RS Stem cell research & therapy 27612948 Stem Cell Res Ther 2016 Sep 9
Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling. Jiang Y, Hu C, Yu S, Yan J, Peng H, Ouyang HW, Tuan RS Arthritis research & therapy 26577823 Arthritis Res Ther 2015 Nov 17
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. Chamberlain JM, Kapur J, Shinnar S, Elm J, Holsti M, Babcock L, Rogers A, Barsan W, Cloyd J, Lowenstein D, Bleck TP, Conwit R, Meinzer C, Cock H, Fountain NB, Underwood E, Connor JT, Silbergleit R, Neurological Emergencies Treatment Trials, Pediatric Emergency Care Applied Research Network investigators Lancet (London, England) 32203691 Lancet 2020 Apr 11
Electroencephalographic Seizures in Emergency Department Patients After Treatment for Convulsive Status Epilepticus. Zehtabchi S, Silbergleit R, Chamberlain JM, Shinnar S, Elm JJ, Underwood E, Rosenthal ES, Bleck TP, Kapur J Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 33337664 J Clin Neurophysiol 2022 Sep 1
Bayesian adaptive trials offer advantages in comparative effectiveness trials: an example in status epilepticus. Connor JT, Elm JJ, Broglio KR, ESETT and ADAPT-IT Investigators Journal of clinical epidemiology 23849147 J Clin Epidemiol 2013 Aug
Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design. Johnston SC, Easton JD, Farrant M, Barsan W, Battenhouse H, Conwit R, Dillon C, Elm J, Lindblad A, Morgenstern L, Poisson SN, Palesch Y International journal of stroke : official journal of the International Stroke Society 23879752 Int J Stroke 2013 Aug
Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis. Legocki LJ, Meurer WJ, Frederiksen S, Lewis RJ, Durkalski VL, Berry DA, Barsan WG, Fetters MD BMC medical ethics 25933921 BMC Med Ethics 2015 May 3
The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study. Connor JT, Broglio KR, Durkalski V, Meurer WJ, Johnston KC Trials 25885963 Trials 2015 Mar 4
Lessons from the Established Status Epilepticus Treatment Trial. Cock HR, Coles LD, Elm J, Silbergleit R, Chamberlain JM, Cloyd JC, Fountain N, Shinnar S, Lowenstein D, Conwit R, Bleck TP, Kapur J Epilepsy & behavior : E&B 31653603 Epilepsy Behav 2019 Dec
Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest. Meurer WJ, Schmitzberger FF, Yeatts S, Ramakrishnan V, Abella B, Aufderheide T, Barsan W, Benoit J, Berry S, Black J, Bozeman N, Broglio K, Brown J, Brown K, Carlozzi N, Caveney A, Cho SM, Chung-Esaki H, Clevenger R, Conwit R, Cooper R, Crudo V, Daya M, Harney D, Hsu C, Johnson NJ, Khan I, Khosla S, Kline P, Kratz A, Kudenchuk P, Lewis RJ, Madiyal C, Meyer S, Mosier J, Mouammar M, Neth M, O'Neil B, Paxton J, Perez S, Perman S, Sozener C, Speers M, Spiteri A, Stevenson V, Sunthankar K, Tonna J, Youngquist S, Geocadin R, Silbergleit R, ICECAP trial investigators Trials 39044295 Trials 2024 Jul 23
The established status epilepticus trial 2013. Bleck T, Cock H, Chamberlain J, Cloyd J, Connor J, Elm J, Fountain N, Jones E, Lowenstein D, Shinnar S, Silbergleit R, Treiman D, Trinka E, Kapur J Epilepsia 24001084 Epilepsia 2013 Sep
An overview of the adaptive designs accelerating promising trials into treatments (ADAPT-IT) project. Meurer WJ, Lewis RJ, Tagle D, Fetters MD, Legocki L, Berry S, Connor J, Durkalski V, Elm J, Zhao W, Frederiksen S, Silbergleit R, Palesch Y, Berry DA, Barsan WG Annals of emergency medicine 22424650 Ann Emerg Med 2012 Oct
Attitudes and opinions regarding confirmatory adaptive clinical trials: a mixed methods analysis from the Adaptive Designs Accelerating Promising Trials into Treatments (ADAPT-IT) project. Meurer WJ, Legocki L, Mawocha S, Frederiksen SM, Guetterman TC, Barsan W, Lewis R, Berry D, Fetters M Trials 27473126 Trials 2016 Jul 29
Effect of insurance status on postacute care among working age stroke survivors. Skolarus LE, Meurer WJ, Burke JF, Prvu Bettger J, Lisabeth LD Neurology 22551730 Neurology 2012 May 15
Spinal cord injury neuroprotection and the promise of flexible adaptive clinical trials. Meurer WJ, Barsan WG World neurosurgery 23851207 World Neurosurg 2014 Sep-Oct
Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus. Rosenthal ES, Elm JJ, Ingles J, Rogers AJ, Terndrup TE, Holsti M, Thomas DG, Babcock L, Okada PJ, Lipsky RH, Miller JB, Hickey RW, Barra ME, Bleck TP, Cloyd JC, Silbergleit R, Lowenstein DH, Coles LD, Kapur J, Shinnar S, Chamberlain JM, Established Status Epilepticus Treatment Trial Study Group Neurology 34032604 Neurology 2021 May 11
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, Shinnar S, Conwit R, Meinzer C, Cock H, Fountain N, Connor JT, Silbergleit R, NETT and PECARN Investigators The New England journal of medicine 31774955 N Engl J Med 2019 Nov 28
Adaptive clinical trials: a partial remedy for the therapeutic misconception? Meurer WJ, Lewis RJ, Berry DA JAMA 22692168 JAMA 2012 Jun 13
Intracerebral hemorrhage mortality is not changing despite declining incidence. Zahuranec DB, Lisabeth LD, Sánchez BN, Smith MA, Brown DL, Garcia NM, Skolarus LE, Meurer WJ, Burke JF, Adelman EE, Morgenstern LB Neurology 24838789 Neurology 2014 Jun 17
Comparison of Bayesian vs Frequentist Adaptive Trial Design in the Stroke Hyperglycemia Insulin Network Effort Trial. Broglio K, Meurer WJ, Durkalski V, Pauls Q, Connor J, Berry D, Lewis RJ, Johnston KC, Barsan WG JAMA network open 35544137 JAMA Netw Open 2022 May 2
Reflections on the Adaptive Designs Accelerating Promising Trials Into Treatments (ADAPT-IT) Process-Findings from a Qualitative Study. Guetterman TC, Fetters MD, Legocki LJ, Mawocha S, Barsan WG, Lewis RJ, Berry DA, Meurer WJ Clinical research and regulatory affairs 26622163 Clin Res Regul Aff 2015 Oct 2
A conceptual model for the development process of confirmatory adaptive clinical trials within an emergency research network. Mawocha SC, Fetters MD, Legocki LJ, Guetterman TC, Frederiksen S, Barsan WG, Lewis RJ, Berry DA, Meurer WJ Clinical trials (London, England) 28135827 Clin Trials 2017 Jun
Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Grosberg A, Alford PW, McCain ML, Parker KK Lab on a chip 22072288 Lab Chip 2011 Dec 21
Microfluidic heart on a chip for higher throughput pharmacological studies. Agarwal A, Goss JA, Cho A, McCain ML, Parker KK Lab on a chip 23807141 Lab Chip 2013 Sep 21
Muscle on a chip: in vitro contractility assays for smooth and striated muscle. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK Journal of pharmacological and toxicological methods 22521339 J Pharmacol Toxicol Methods 2012 May-Jun
The contribution of cellular mechanotransduction to cardiomyocyte form and function. Sheehy SP, Grosberg A, Parker KK Biomechanics and modeling in mechanobiology 22772714 Biomech Model Mechanobiol 2012 Nov
A mini-microscope for in situ monitoring of cells. Kim SB, Koo KI, Bae H, Dokmeci MR, Hamilton GA, Bahinski A, Kim SM, Ingber DE, Khademhosseini A Lab on a chip 22911426 Lab Chip 2012 Oct 21
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander MA, Ingber DE Science translational medicine 23136042 Sci Transl Med 2012 Nov 7
Clear castable polyurethane elastomer for fabrication of microfluidic devices. Domansky K, Leslie DC, McKinney J, Fraser JP, Sliz JD, Hamkins-Indik T, Hamilton GA, Bahinski A, Ingber DE Lab on a chip 23954953 Lab Chip 2013 Oct 7
Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip. Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK Advanced functional materials 26213529 Adv Funct Mater 2013 Aug 12
Microfabrication of human organs-on-chips. Huh D, Kim HJ, Fraser JP, Shea DE, Khan M, Bahinski A, Hamilton GA, Ingber DE Nature protocols 24113786 Nat Protoc 2013 Nov
Informatics and standards for nanomedicine technology. Thomas DG, Klaessig F, Harper SL, Fritts M, Hoover MD, Gaheen S, Stokes TH, Reznik-Zellen R, Freund ET, Klemm JD, Paik DS, Baker NA Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 21721140 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011 Sep-Oct
Manganese-based MRI contrast agents: past, present and future. Pan D, Schmieder AH, Wickline SA, Lanza GM Tetrahedron 22043109 Tetrahedron 2011 Nov 4
Antiangiogenic nanotherapy with lipase-labile Sn-2 fumagillin prodrug. Pan D, Sanyal N, Schmieder AH, Senpan A, Kim B, Yang X, Hu G, Allen JS, Gross RW, Wickline SA, Lanza GM Nanomedicine (London, England) 22709347 Nanomedicine (Lond) 2012 Oct
Variable antibody-dependent activation of complement by functionalized phospholipid nanoparticle surfaces. Pham CT, Mitchell LM, Huang JL, Lubniewski CM, Schall OF, Killgore JK, Pan D, Wickline SA, Lanza GM, Hourcade DE The Journal of biological chemistry 21047788 J Biol Chem 2011 Jan 7
MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation. Bulte JW, Schmieder AH, Keupp J, Caruthers SD, Wickline SA, Lanza GM Nanomedicine : nanotechnology, biology, and medicine 24832959 Nanomedicine 2014 Oct
Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers. Daily MD, Olsen BN, Schlesinger PH, Ory DS, Baker NA Journal of chemical theory and computation 24910542 J Chem Theory Comput 2014 May 13
Standardizing data. Baker NA, Klemm JD, Harper SL, Gaheen S, Heiskanen M, Rocca-Serra P, Sansone SA Nature nanotechnology 23380926 Nat Nanotechnol 2013 Feb
Nanotherapeutic approaches for the treatment of rheumatoid arthritis. Pham CT Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 21837725 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011 Nov-Dec
Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using α(v)β₃-targeted theranostic nanoparticles. Pan D, Schmieder AH, Wang K, Yang X, Senpan A, Cui G, Killgore K, Kim B, Allen JS, Zhang H, Caruthers SD, Shen B, Wickline SA, Lanza GM Theranostics 24723979 Theranostics 2014
Molecular imaging with computed tomography. Lanza GM, Pan D Contrast media & molecular imaging 24470289 Contrast Media Mol Imaging 2014 Jan-Feb
Interaction of melittin peptides with perfluorocarbon nanoemulsion particles. Lee SJ, Schlesinger PH, Wickline SA, Lanza GM, Baker NA The journal of physical chemistry. B 22050303 J Phys Chem B 2011 Dec 29
ISA-TAB-Nano: a specification for sharing nanomaterial research data in spreadsheet-based format. Thomas DG, Gaheen S, Harper SL, Fritts M, Klaessig F, Hahn-Dantona E, Paik D, Pan S, Stafford GA, Freund ET, Klemm JD, Baker NA BMC biotechnology 23311978 BMC Biotechnol 2013 Jan 14
Suppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticles. Zhou HF, Yan H, Senpan A, Wickline SA, Pan D, Lanza GM, Pham CT Biomaterials 22922023 Biomaterials 2012 Nov
alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV Theranostics 25553103 Theranostics 2015
Multicolor computed tomographic molecular imaging with noncrystalline high-metal-density nanobeacons. Pan D, Schirra CO, Wickline SA, Lanza GM Contrast media & molecular imaging 24470291 Contrast Media Mol Imaging 2014 Jan-Feb
Nanoinformatics workshop report: Current resources, community needs, and the proposal of a collaborative framework for data sharing and information integration. Harper SL, Hutchison JE, Baker N, Ostraat M, Tinkle S, Steevens J, Hoover MD, Adamick J, Rajan K, Gaheen S, Cohen Y, Nel A, Cachau RE, Tuominen M Computational science & discovery 24454543 Comput Sci Discov 2013
A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. Pan D, Kim B, Hu G, Gupta DS, Senpan A, Yang X, Schmieder A, Swain C, Wickline SA, Tomasson MH, Lanza GM Nanomedicine (London, England) 25600969 Nanomedicine (Lond) 2015 Jan
Near infrared imaging of EGFR of oral squamous cell carcinoma in mice administered arsenic trioxide. Zhang L, Wang K, Zhao F, Hu W, Chen J, Lanza GM, Shen B, Zhang B PloS one 23029451 PLoS One 2012
Second Generation Gold Nanobeacons for Robust K-Edge Imaging with Multi-Energy CT. Schirra CO, Senpan A, Roessl E, Thran A, Stacy AJ, Wu L, Proska R, Pan D Journal of materials chemistry 23185109 J Mater Chem 2012 Jan 1
Angiogenesis is required for stress fracture healing in rats. Tomlinson RE, McKenzie JA, Schmieder AH, Wohl GR, Lanza GM, Silva MJ Bone 23044046 Bone 2013 Jan
An early investigation of ytterbium nanocolloids for selective and quantitative "multicolor" spectral CT imaging. Pan D, Schirra CO, Senpan A, Schmieder AH, Stacy AJ, Roessl E, Thran A, Wickline SA, Proska R, Lanza GM ACS nano 22385324 ACS Nano 2012 Apr 24
Characterization of early neovascular response to acute lung ischemia using simultaneous (19)F/ (1)H MR molecular imaging. Schmieder AH, Wang K, Zhang H, Senpan A, Pan D, Keupp J, Caruthers SD, Wickline SA, Shen B, Wagner EM, Lanza GM Angiogenesis 23918207 Angiogenesis 2014 Jan
A brief account of nanoparticle contrast agents for photoacoustic imaging. Pan D, Kim B, Wang LV, Lanza GM Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 23983210 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2013 Nov-Dec
Application of a hemolysis assay for analysis of complement activation by perfluorocarbon nanoparticles. Pham CT, Thomas DG, Beiser J, Mitchell LM, Huang JL, Senpan A, Hu G, Gordon M, Baker NA, Pan D, Lanza GM, Hourcade DE Nanomedicine : nanotechnology, biology, and medicine 24211337 Nanomedicine 2014 Apr
Assessing the barriers to image-guided drug delivery. Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, Zheng G, Farahani K Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 24339356 Wiley Interdiscip Rev Nanomed Nanobiotechnol 2014 Jan-Feb
Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers. Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM Nanomedicine : nanotechnology, biology, and medicine 25652900 Nanomedicine 2015 Apr
Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity. Harper B, Thomas D, Chikkagoudar S, Baker N, Tang K, Heredia-Langner A, Lins R, Harper S Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 26069453 J Nanopart Res 2015
ICAM-1 and nanomedicine: nature's doorway to the extravascular tissue realm. Lanza GM Arteriosclerosis, thrombosis, and vascular biology 22517363 Arterioscler Thromb Vasc Biol 2012 May
Simulation of fusion-mediated nanoemulsion interactions with model lipid bilayers. Lee SJ, Schlesinger PH, Wickline SA, Lanza GM, Baker NA Soft matter 22712024 Soft Matter 2012 Jan 1
Rapid quantification of oxygen tension in blood flow with a fluorine nanoparticle reporter and a novel blood flow-enhanced-saturation-recovery sequence. Hu L, Chen J, Yang X, Caruthers SD, Lanza GM, Wickline SA Magnetic resonance in medicine 22915328 Magn Reson Med 2013 Jul
Nanoinformatics: developing new computing applications for nanomedicine. Maojo V, Fritts M, Martin-Sanchez F, De la Iglesia D, Cachau RE, Garcia-Remesal M, Crespo J, Mitchell JA, Anguita A, Baker N, Barreiro JM, Benitez SE, De la Calle G, Facelli JC, Ghazal P, Geissbuhler A, Gonzalez-Nilo F, Graf N, Grangeat P, Hermosilla I, Hussein R, Kern J, Koch S, Legre Y, Lopez-Alonso V, Lopez-Campos G, Milanesi L, Moustakis V, Munteanu C, Otero P, Pazos A, Perez-Rey D, Potamias G, Sanz F, Kulikowski C Computing in science & engineering 22942787 Comput Sci Eng 2012 Jun 1
Physicochemical signatures of nanoparticle-dependent complement activation. Thomas DG, Chikkagoudar S, Heredia-Langer A, Tardiff MF, Xu Z, Hourcade DE, Pham CT, Lanza GM, Weinberger KQ, Baker NA Computational science & discovery 25254068 Comput Sci Discov 2014 Mar 21
Angiogenesis and airway reactivity in asthmatic Brown Norway rats. Wagner EM, Jenkins J, Schmieder A, Eldridge L, Zhang Q, Moldobaeva A, Zhang H, Allen JS, Yang X, Mitzner W, Keupp J, Caruthers SD, Wickline SA, Lanza GM Angiogenesis 25149641 Angiogenesis 2015 Jan
Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide. Zhou HF, Yan H, Hu Y, Springer LE, Yang X, Wickline SA, Pan D, Lanza GM, Pham CT ACS nano 24941020 ACS Nano 2014 Jul 22
Annotating the structure and components of a nanoparticle formulation using computable string expressions. Thomas DG, Chikkagoudar S, Chappell AR, Baker NA Proceedings. IEEE International Conference on Bioinformatics and Biomedicine 24533226 Proceedings (IEEE Int Conf Bioinformatics Biomed) 2012 Dec 31
Antagonizing the αv β3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading. Tomlinson RE, Schmieder AH, Quirk JD, Lanza GM, Silva MJ Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 24644077 J Bone Miner Res 2014 Sep
Balanced UTE-SSFP for 19F MR imaging of complex spectra. Goette MJ, Keupp J, Rahmer J, Lanza GM, Wickline SA, Caruthers SD Magnetic resonance in medicine 25163853 Magn Reson Med 2015 Aug

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