Funded Research

The Regulatory Science Program has transitioned from Common Fund support. For more information please visit https://commonfund.nih.gov/regulatoryscience.

Please note that since the Regulatory Science program is no longer being supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis.

 

Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) RFA-RM-11-022
PI Name Institution Name Title

GEORGE, STEVEN CARL

UNIVERSITY OF CALIFORNIA IRVINE

An integrated in vitro model of perfused tumor and cardiac tissue

GRIFFITH, LINDA G

MASSACHUSETTS INST OF TECH

All-Human Microphysical Model of Metastasis Therapy

HEALY, KEVIN EDWARD (contact)
LEE, LUKE P.

UNIVERSITY OF CALIFORNIA BERKELEY

Disease-Specific Integrated Microphysiological Human Tissue Models

HIMMELFARB, JONATHAN

UNIVERSITY OF WASHINGTON

A Tissue Engineered Human Kidney Microphysiological System

PARKER, KEVIN KIT

HARVARD UNIVERSITY

Human Cardio-Pulmonary System on a Chip

TAYLOR, D. LANSING LANSING (contact)
YARMUSH, MARTIN L

MASSACHUSETTS GENERAL HOSPITAL

A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity

THOMSON, JAMES ALEXANDER

MORGRIDGE INSTITUTE FOR RESEARCH

Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity

TRUSKEY, GEORGE A

DUKE UNIVERSITY

Circulatory system and integrated muscle tissue for drug and tissue toxicity

VUNJAK-NOVAKOVIC, GORDANA COLUMBIA UNIV NEW YORK MORNINGSIDE Integrated heart-liver-vascular systems for drug testing in human health and dise

WIKSWO, JOHN PETER (contact)
NISWENDER, KEVIN D
WEBB, DONNA J

VANDERBILT UNIVERSITY

Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses

WOODRUFF, TERESA K NORTHWESTERN UNIVERSITY AT CHICAGO Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System
 
 
Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH2/UH3) RFA-TR-12-004
PI Name Institution Name Title

AKHLAGHI, FATEMEH (contact)
LEGGIO, LORENZO

UNIVERSITY OF RHODE ISLAND

A Novel Compound for Alcoholism Treatment: a Translational Strategy

BREIER, ALAN

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

The Efficacy and Safety of a Selective Estrogen Receptor Beta agonist (LY500307)

BRUNZELL, DARLENE H (contact)
PERKINS, KENNETH ALAN

VIRGINIA COMMONWEALTH UNIVERSITY

Medication development of a novel therapeutic for smoking cessation

EISSA, TONY

BAYLOR COLLEGE OF MEDICINE

Therapeutic Strategy for LAM (Lymphangioleiomyomatosis)

KRYSTAL, JOHN H

YALE UNIVERSITY

Translational Neuroscience Optimization of GlyT1 Inhibitor

MILLER, JORDAN D (contact)
ENRIQUEZ-SARANO, MAURICE
SCHAFF, HARTZELL V.

MAYO CLINIC ROCHESTER

Therapeutic Strategy to slow progression of calcific aortic valve stenosis

STRITTMATTER, STEPHEN M (contact)
NYGAARD, HAAKON BERGE
VAN DYCK, CHRISTOPHER H

YALE UNIVERSITY

Fyn Inhibition by AZD0530 for Alzheimers Disease

WAGNER, KATHRYN R (contact)
FROEHNER, STANLEY C

HUGO W. MOSER RES INST KENNEDY KRIEGER

Partnering to treat an Orphan Disease Duchenne Muscular Dystrophy


 

Limited Competition for NIH-Industry Pilot Program: Discovering New Therapeutic Uses for Existing Molecules (UH3) RFA-TR-12-005
PI Name Institution Name Title

ANNEX, BRIAN H

UNIVERSITY OF VIRGINIA

Reuse of ZD4054 for patients with symptomatic PAD


 

Stem/Progenitor Cell-Derived Human Micro-organs and -tissues (U18) RFA-RM-12-001
PI Name Institution Name Title

CHRISTIANO, ANGELA M

COLUMBIA UNIVERSITY HEALTH SCIENCES

Modeling complex diseases using iPSC-derived skin constructs

DONOWITZ, MARK

JOHNS HOPKINS UNIVERSITY

Human Intestinal Organoids: Pre-Clinical Models of Non-Inflammatory Diarrhea

HARTUNG, THOMAS

JOHNS HOPKINS UNIVERSITY

A 3D Model of Human Brain Development for Studying Gene/Environment Interactions

LYNCH, JOHN P

UNIVERSITY OF PENNSYLVANIA

Modeling oxidative stress and DNA damage using GI organotypic culture systems

NICHOLS, JOAN E

UNIVERSITY OF TEXAS MEDICAL BR GALVESTON

3D human lung model to study lung disease and formation of fibrosis

TUAN, ROCKY S

UNIVERSITY OF PITTSBURGH

3-D Osteochondral Micro-tissue to Model Pathogenesis of Osteoarthritis

WELLS, JAMES M

CINCINNATI CHILDRENS HOSPITAL MED CTR

Generating Human Intestinal Organoids with an ENS


 

Integrated Microphysiological Systems for Drug Efficacy and Toxicity Testing in Human Health and Disease (UH2/UH3) RFA-RM-11-022
PI Name Institution Name Title

GEORGE, STEVEN CARL

UNIVERSITY OF CALIFORNIA IRVINE

An integrated in vitro model of perfused tumor and cardiac tissue

GRIFFITH, LINDA G

MASSACHUSETTS INST OF TECH

All-Human Microphysical Model of Metastasis Therapy

HEALY, KEVIN EDWARD (contact)
LEE, LUKE P.

UNIVERSITY OF CALIFORNIA BERKELEY

Disease-Specific Integrated Microphysiological Human Tissue Models

HIMMELFARB, JONATHAN

UNIVERSITY OF WASHINGTON

A Tissue Engineered Human Kidney Microphysiological System

PARKER, KEVIN KIT

HARVARD UNIVERSITY

Human Cardio-Pulmonary System on a Chip

SHULER, MICHAEL L (contact)
HICKMAN, JAMES J

CORNELL UNIVERSITY

Microphysiologial systems and low cost microfluidic platform with analytics

TAYLOR, D. LANSING LANSING (contact)
YARMUSH, MARTIN L

MASSACHUSETTS GENERAL HOSPITAL

A 3D biomimetic liver sinusoid construct for predicting physiology and toxicity

THOMSON, JAMES ALEXANDER

MORGRIDGE INSTITUTE FOR RESEARCH

Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and Teratogenicity

TRUSKEY, GEORGE A

DUKE UNIVERSITY

Circulatory system and integrated muscle tissue for drug and tissue toxicity

VUNJAK-NOVAKOVIC, GORDANA COLUMBIA UNIV NEW YORK MORNINGSIDE Integrated heart-liver-vascular systems for drug testing in human health and dise

WIKSWO, JOHN PETER (contact)
NISWENDER, KEVIN D
WEBB, DONNA J

VANDERBILT UNIVERSITY

Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin Responses

WOODRUFF, TERESA K NORTHWESTERN UNIVERSITY AT CHICAGO Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic System


 

Advancing Regulatory Science through Novel Research and Science-Based Technologies (U01)
RFA-RM-10-006
PI Name Institution Name Title
BARSAN, WILLIAM G (contact)
BERRY, DONALD A
LEWIS, ROGER J
UNIVERSITY OF MICHIGAN AT ANN ARBOR Accelerating Drug and Device Evaluation through Innovative Clinical Trial Design
CERVEN, DANIEL R (contact)
DEGEORGE, GEORGE L.
MB RESEARCH LABORATORIES, INC. Replacement Ocular Battery (ROBatt)
HOURCADE, DENNIS E. WASHINGTON UNIVERSITY Characterization/Bioinformatics-modeling of Nanoparticle: Complement Interactions
INGBER, DONALD E HARVARD UNIVERSITY (MEDICAL SCHOOL) Heart-Lung Micromachine for Safety and Efficacy Testing

 

This page last reviewed on January 18, 2018