Transformative High Resolution Cryo-Electron Microscopy (78)
Publication TitleAuthorsJournalPublication DatePage NoPubMedID
Micropatterning Transmission Electron Microscopy Grids to Direct Cell Positioning within Whole-Cell Cryo-Electron Tomography Workflows.Sibert, Bryan S; Kim, Joseph Y; Yang, Jie E; Wright, Elizabeth RJournal of visualized experiments : JoVE2021 09 1334570100
Computational Methods for Single-Particle Electron Cryomicroscopy.Singer, Amit; Sigworth, Fred JAnnual review of biomedical data science2020 0734485850
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants.Schmitz, Aaron J; Turner, Jackson S; Liu, Zhuoming; Zhou, Julian Q; Aziati, Ishmael D; Chen, Rita E; Joshi, Astha; Bricker, Traci L; Darling, Tamarand L; Adelsberg, Daniel C; Altomare, Clara G; Alsoussi, Wafaa B; Case, James Brett; VanBlargan, Laura A; Lei, Tingting; Thapa, Mahima; Amanat, Fatima; Jeevan, Trushar; Fabrizio, Thomas; O'Halloran, Jane A; Shi, Pei-Yong; Presti, Rachel M; Webby, Richard J; Krammer, Florian; Whelan, Sean P J; Bajic, Goran; Diamond, Michael S; Boon, Adrianus C M; Ellebedy, Ali HImmunity2021 09 1434464596
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation.Rathinaswamy, Manoj K; Dalwadi, Udit; Fleming, Kaelin D; Adams, Carson; Stariha, Jordan T B; Pardon, Els; Baek, Minkyung; Vadas, Oscar; DiMaio, Frank; Steyaert, Jan; Hansen, Scott D; Yip, Calvin K; Burke, John EScience advances2021 Aug34452907
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome.Zhang, Kaiming; Zheludev, Ivan N; Hagey, Rachel J; Haslecker, Raphael; Hou, Yixuan J; Kretsch, Rachael; Pintilie, Grigore D; Rangan, Ramya; Kladwang, Wipapat; Li, Shanshan; Wu, Marie Teng-Pei; Pham, Edward A; Bernardin-Souibgui, Claire; Baric, Ralph S; Sheahan, Timothy P; D'Souza, Victoria; Glenn, Jeffrey S; Chiu, Wah; Das, RhijuNature structural & molecular biology2021 0934426697
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.Plenge, Per; Yang, Dongxue; Salomon, Kristine; Laursen, Louise; Kalenderoglou, Iris E; Newman, Amy H; Gouaux, Eric; Coleman, Jonathan A; Loland, Claus JNature communications2021 08 2034417466
Structural and mechanistic basis for protein glutamylation by the kinase fold.Osinski, Adam; Black, Miles H; Pawłowski, Krzysztof; Chen, Zhe; Li, Yang; Tagliabracci, Vincent SMolecular cell2021 Aug 1234407442
Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport.Su, Chih-Chia; Klenotic, Philip A; Cui, Meng; Lyu, Meinan; Morgan, Christopher E; Yu, Edward WPLoS biology2021 Aug34383749
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution.Su, Zhaoming; Zhang, Kaiming; Kappel, Kalli; Li, Shanshan; Palo, Michael Z; Pintilie, Grigore D; Rangan, Ramya; Luo, Bingnan; Wei, Yuquan; Das, Rhiju; Chiu, WahNature2021 Aug34381213
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes.Sun, Dapeng; Sang, Zhe; Kim, Yong Joon; Xiang, Yufei; Cohen, Tomer; Belford, Anna K; Huet, Alexis; Conway, James F; Sun, Ji; Taylor, Derek J; Schneidman-Duhovny, Dina; Zhang, Cheng; Huang, Wei; Shi, YiNature communications2021 08 0334344900
Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.Hu, Qi; Botuyan, Maria Victoria; Zhao, Debiao; Cui, Gaofeng; Mer, Elie; Mer, GeorgesNature2021 0834321665
Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60.Wang, Joseph Che-Yen; Chen, LinglingScientific reports2021 07 2034285302
Structural basis for potassium transport in prokaryotes by KdpFABC.Sweet, Marie E; Larsen, Casper; Zhang, Xihui; Schlame, Michael; Pedersen, Bjørn P; Stokes, David LProceedings of the National Academy of Sciences of the United States of America2021 Jul 2034272288
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP.Lopez-Redondo, Maria; Fan, Shujie; Koide, Akiko; Koide, Shohei; Beckstein, Oliver; Stokes, David LThe Journal of general physiology2021 Aug 0234254979
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; Lu, Xiaozhi; Parks, Robert; Sutherland, Laura L; Oguin 3rd, Thomas H; McDanal, Charlene; Perez, Lautaro G; Mansouri, Katayoun; Gobeil, Sophie M C; Janowska, Katarzyna; Stalls, Victoria; Kopp, Megan; Cai, Fangping; Lee, Esther; Foulger, Andrew; Hernandez, Giovanna E; Sanzone, Aja; Tilahun, Kedamawit; Jiang, Chuancang; Tse, Longping V; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Cronin, Kenneth; Gee-Lai, Victoria; Deyton, Margaret; Barr, Maggie; Von Holle, Tarra; Macintyre, Andrew N; Stover, Erica; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Scobey, Trevor D; Rountree, Wes; Wang, Yunfei; Moody, M Anthony; Cain, Derek W; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Schmidt, Aaron G; Teng, I-Ting; Zhou, Tongqing; Kwong, Peter D; Mascola, John R; Graham, Barney S; Moore, Ian N; Seder, Robert; Andersen, Hanne; Lewis, Mark G; Montefiori, David C; Sempowski, Gregory D; Baric, Ralph S; Acharya, Priyamvada; Haynes, Barton F; Saunders, Kevin OCell2021 08 0534242577
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.Nadezhdin, Kirill D; Neuberger, Arthur; Trofimov, Yuri A; Krylov, Nikolay A; Sinica, Viktor; Kupko, Nikita; Vlachova, Viktorie; Zakharian, Eleonora; Efremov, Roman G; Sobolevsky, Alexander INature structural & molecular biology2021 0734239124
Heat-dependent opening of TRPV1 in the presence of capsaicin.Kwon, Do Hoon; Zhang, Feng; Suo, Yang; Bouvette, Jonathan; Borgnia, Mario J; Lee, Seok-YongNature structural & molecular biology2021 0734239123
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.Chen, Peng; Zeng, Ji; Liu, Zheng; Thaker, Hatim; Wang, Siyu; Tian, Songhai; Zhang, Jie; Tao, Liang; Gutierrez, Craig B; Xing, Li; Gerhard, Ralf; Huang, Lan; Dong, Min; Jin, RongshengNature communications2021 06 1834145250
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies.Cerutti, Gabriele; Rapp, Micah; Guo, Yicheng; Bahna, Fabiana; Bimela, Jude; Reddem, Eswar R; Yu, Jian; Wang, Pengfei; Liu, Lihong; Huang, Yaoxing; Ho, David D; Kwong, Peter D; Sheng, Zizhang; Shapiro, LawrenceStructure (London, England : 1993)2021 07 0134111408
Structural insight on assembly-line catalysis in terpene biosynthesis.Faylo, Jacque L; van Eeuwen, Trevor; Kim, Hee Jong; Gorbea Colón, Jose J; Garcia, Benjamin A; Murakami, Kenji; Christianson, David WNature communications2021 06 0934108468
Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair.van Eeuwen, Trevor; Shim, Yoonjung; Kim, Hee Jong; Zhao, Tingting; Basu, Shrabani; Garcia, Benjamin A; Kaplan, Craig D; Min, Jung-Hyun; Murakami, KenjiNature communications2021 06 0734099686
Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy.Driggers, Camden M; Shyng, Show-LingMethods in enzymology202134099169
TRPV3 expression and purification for structure determination by Cryo-EM.Neuberger, Arthur; Nadezhdin, Kirill D; Sobolevsky, Alexander IMethods in enzymology202134059288
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.Sharif, Humayun; Hollingsworth, L Robert; Griswold, Andrew R; Hsiao, Jeffrey C; Wang, Qinghui; Bachovchin, Daniel A; Wu, HaoImmunity2021 07 1334019797
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.Williams, Wilton B; Meyerhoff, R Ryan; Edwards, R J; Li, Hui; Manne, Kartik; Nicely, Nathan I; Henderson, Rory; Zhou, Ye; Janowska, Katarzyna; Mansouri, Katayoun; Gobeil, Sophie; Evangelous, Tyler; Hora, Bhavna; Berry, Madison; Abuahmad, A Yousef; Sprenz, Jordan; Deyton, Margaret; Stalls, Victoria; Kopp, Megan; Hsu, Allen L; Borgnia, Mario J; Stewart-Jones, Guillaume B E; Lee, Matthew S; Bronkema, Naomi; Moody, M Anthony; Wiehe, Kevin; Bradley, Todd; Alam, S Munir; Parks, Robert J; Foulger, Andrew; Oguin, Thomas; Sempowski, Gregory D; Bonsignori, Mattia; LaBranche, Celia C; Montefiori, David C; Seaman, Michael; Santra, Sampa; Perfect, John; Francica, Joseph R; Lynn, Geoffrey M; Aussedat, Baptiste; Walkowicz, William E; Laga, Richard; Kelsoe, Garnett; Saunders, Kevin O; Fera, Daniela; Kwong, Peter D; Seder, Robert A; Bartesaghi, Alberto; Shaw, George M; Acharya, Priyamvada; Haynes, Barton FCell2021 05 2734019795
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.Yu, Jie; Rao, Prashant; Clark, Sarah; Mitra, Jaba; Ha, Taekjip; Gouaux, EricNature2021 Jun33981040
Cryo-EM structure of a thermostable bacterial nanocompartment.Wiryaman, Timothy; Toor, NavtejIUCrJ2021 May 0133953921
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T; Chait, Brian T; Shaw, David E; Landick, Robert; Darst, Seth A; Campbell, Elizabeth AProceedings of the National Academy of Sciences of the United States of America2021 05 1133883267
Structural basis of long-range to short-range synaptic transition in NHEJ.Chen, Siyu; Lee, Linda; Naila, Tasmin; Fishbain, Susan; Wang, Annie; Tomkinson, Alan E; Lees-Miller, Susan P; He, YuanNature2021 May33854234
Extracellular cap domain is an essential component of the TRPV1 gating mechanism.Nadezhdin, Kirill D; Neuberger, Arthur; Nikolaev, Yury A; Murphy, Lyle A; Gracheva, Elena O; Bagriantsev, Sviatoslav N; Sobolevsky, Alexander INature communications2021 04 1233846324
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.Shen, Betty W; Quispe, Joel D; Luyten, Yvette; McGough, Benjamin E; Morgan, Richard D; Stoddard, Barry LStructure (London, England : 1993)2021 Jun 0333826880
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.Rapp, Micah; Guo, Yicheng; Reddem, Eswar R; Yu, Jian; Liu, Lihong; Wang, Pengfei; Cerutti, Gabriele; Katsamba, Phinikoula; Bimela, Jude S; Bahna, Fabiana A; Mannepalli, Seetha M; Zhang, Baoshan; Kwong, Peter D; Huang, Yaoxing; Ho, David D; Shapiro, Lawrence; Sheng, ZizhangCell reports2021 04 0633794145
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.Cerutti, Gabriele; Guo, Yicheng; Zhou, Tongqing; Gorman, Jason; Lee, Myungjin; Rapp, Micah; Reddem, Eswar R; Yu, Jian; Bahna, Fabiana; Bimela, Jude; Huang, Yaoxing; Katsamba, Phinikoula S; Liu, Lihong; Nair, Manoj S; Rawi, Reda; Olia, Adam S; Wang, Pengfei; Zhang, Baoshan; Chuang, Gwo-Yu; Ho, David D; Sheng, Zizhang; Kwong, Peter D; Shapiro, LawrenceCell host & microbe2021 05 1233789084
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.Jette, Claudia A; Barnes, Christopher O; Kirk, Sharon M; Melillo, Bruno; Smith 3rd, Amos B; Bjorkman, Pamela JNature communications2021 03 2933782388
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T; Chait, Brian T; Shaw, David E; Landick, Robert; Darst, Seth A; Campbell, Elizabeth AbioRxiv : the preprint server for biology2021 Mar 1433758867
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes.Sun, Dapeng; Sang, Zhe; Kim, Yong Joon; Xiang, Yufei; Cohen, Tomer; Belford, Anna K; Huet, Alexis; Conway, James F; Sun, Ji; Taylor, Derek J; Schneidman-Duhovny, Dina; Zhang, Cheng; Huang, Wei; Shi, YibioRxiv : the preprint server for biology2021 Mar 1033758850
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.Noviello, Colleen M; Gharpure, Anant; Mukhtasimova, Nuriya; Cabuco, Rico; Baxter, Leah; Borek, Dominika; Sine, Steven M; Hibbs, Ryan ECell2021 Apr 1533735609
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.Hollingsworth, L Robert; Sharif, Humayun; Griswold, Andrew R; Fontana, Pietro; Mintseris, Julian; Dagbay, Kevin B; Paulo, Joao A; Gygi, Steven P; Bachovchin, Daniel A; Wu, HaoNature2021 Apr33731932
Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.Moghadamchargari, Zahra; Shirzadeh, Mehdi; Liu, Chang; Schrecke, Samantha; Packianathan, Charles; Russell, David H; Zhao, Minglei; Laganowsky, ArthurProceedings of the National Academy of Sciences of the United States of America2021 Mar 2333723061
Structure of the human Mediator-bound transcription preinitiation complex.Abdella, R; Talyzina, A; Chen, S; Inouye, C J; Tjian, R; He, YScience (New York, N.Y.)2021 04 0233707221
CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy.Yang, Jie E; Larson, Matthew R; Sibert, Bryan S; Shrum, Samantha; Wright, Elizabeth RJournal of structural biology2021 Feb 1833610654
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.Feldman, Jared; Bals, Julia; Altomare, Clara G; St Denis, Kerri; Lam, Evan C; Hauser, Blake M; Ronsard, Larance; Sangesland, Maya; Moreno, Thalia Bracamonte; Okonkwo, Vintus; Hartojo, Nathania; Balazs, Alejandro B; Bajic, Goran; Lingwood, Daniel; Schmidt, Aaron GbioRxiv : the preprint server for biology2021 Jul 0933594359
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.Grau, Daniel; Zhang, Yixiao; Lee, Chul-Hwan; Valencia-Sánchez, Marco; Zhang, Jenny; Wang, Miao; Holder, Marlene; Svetlov, Vladimir; Tan, Dongyan; Nudler, Evgeny; Reinberg, Danny; Walz, Thomas; Armache, Karim-JeanNature communications2021 01 2933514705
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven CACS omega2021 Jan 1233458462
The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain.Rangarajan, Erumbi S; Izard, TinaInternational journal of molecular sciences2021 Jan 1133440717
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.Robert Hollingsworth, L; David, Liron; Li, Yang; Griswold, Andrew R; Ruan, Jianbin; Sharif, Humayun; Fontana, Pietro; Orth-He, Elizabeth L; Fu, Tian-Min; Bachovchin, Daniel A; Wu, HaoNature communications2021 01 0833420033
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.Gobeil, Sophie M-C; Janowska, Katarzyna; McDowell, Shana; Mansouri, Katayoun; Parks, Robert; Manne, Kartik; Stalls, Victoria; Kopp, Megan F; Henderson, Rory; Edwards, Robert J; Haynes, Barton F; Acharya, PriyamvadaCell reports2021 01 1233417835
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.Kato, Kazuki; Ahmad, Sadeem; Zhu, Zixiang; Young, Janet M; Mu, Xin; Park, Sehoon; Malik, Harmit S; Hur, SunMolecular cell2021 02 0433373584
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.Zhou, Tongqing; Tsybovsky, Yaroslav; Gorman, Jason; Rapp, Micah; Cerutti, Gabriele; Chuang, Gwo-Yu; Katsamba, Phinikoula S; Sampson, Jared M; Schön, Arne; Bimela, Jude; Boyington, Jeffrey C; Nazzari, Alexandra; Olia, Adam S; Shi, Wei; Sastry, Mallika; Stephens, Tyler; Stuckey, Jonathan; Teng, I-Ting; Wang, Pengfei; Wang, Shuishu; Zhang, Baoshan; Friesner, Richard A; Ho, David D; Mascola, John R; Shapiro, Lawrence; Kwong, Peter DCell host & microbe.2020 12 09;33271067
The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.Santosh, Vishaka; Musayev, Faik N; Jaiswal, Rahul; Zárate-Pérez, Francisco; Vandewinkel, Bram; Dierckx, Caroline; Endicott, Molly; Sharifi, Kamyar; Dryden, Kelly; Henckaerts, Els; Escalante, Carlos RNucleic acids research2020 12 1633270897
The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors.Silveria, Mark A; Large, Edward E; Zane, Grant M; White, Tommi A; Chapman, Michael SViruses2020 11 1833218165
Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.Olinares, Paul Dominic B; Kang, Jin Young; Llewellyn, Eliza; Chiu, Courtney; Chen, James; Malone, Brandon; Saecker, Ruth M; Campbell, Elizabeth A; Darst, Seth A; Chait, Brian TStructure (London, England : 1993)2021 02 0433217329
Structural Basis for Virulence Activation of Francisella tularensis.Travis, Brady A; Ramsey, Kathryn M; Prezioso, Samantha M; Tallo, Thomas; Wandzilak, Jamie M; Hsu, Allen; Borgnia, Mario; Bartesaghi, Alberto; Dove, Simon L; Brennan, Richard G; Schumacher, Maria AMolecular cell2021 01 0733217319
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.Liu, Chang; Reese, Rebecca; Vu, Simon; Rougé, Lionel; Shields, Shannon D; Kakiuchi-Kiyota, Satoko; Chen, Huifen; Johnson, Kevin; Shi, Yu Patrick; Chernov-Rogan, Tania; Greiner, Demi Maria Zabala; Kohli, Pawan Bir; Hackos, David; Brillantes, Bobby; Tam, Christine; Li, Tianbo; Wang, Jianyong; Safina, Brian; Magnuson, Steve; Volgraf, Matthew; Payandeh, Jian; Zheng, Jie; Rohou, Alexis; Chen, JunNeuron2021 01 2033152265
Adeno-Associated Virus (AAV-DJ)-Cryo-EM Structure at 1.56 Å Resolution.Xie, Qing; Yoshioka, Craig K; Chapman, Michael SViruses2020 10 2033092282
Synthetic group A streptogramin antibiotics that overcome Vat resistance.Li, Qi; Pellegrino, Jenna; Lee, D John; Tran, Arthur A; Chaires, Hector A; Wang, Ruoxi; Park, Jesslyn E; Ji, Kaijie; Chow, David; Zhang, Na; Brilot, Axel F; Biel, Justin T; van Zundert, Gydo; Borrelli, Kenneth; Shinabarger, Dean; Wolfe, Cindy; Murray, Beverly; Jacobson, Matthew P; Mühle, Estelle; Chesneau, Olivier; Fraser, James S; Seiple, Ian BNature2020 1032968273
Light-coupled cryo-plunger for time-resolved cryo-EM.Yoder, Nate; Jalali-Yazdi, Farzad; Noreng, Sigrid; Houser, Alexandra; Baconguis, Isabelle; Gouaux, EricJournal of structural biology.2020 Sep 17;32950604
Shared structural mechanisms of general anaesthetics and benzodiazepines.Kim, Jeong Joo; Gharpure, Anant; Teng, Jinfeng; Zhuang, Yuxuan; Howard, Rebecca J; Zhu, Shaotong; Noviello, Colleen M; Walsh Jr, Richard M; Lindahl, Erik; Hibbs, Ryan ENature2020 0932879488
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex.Durie, Clarissa L; Sheedlo, Michael J; Chung, Jeong Min; Byrne, Brenda G; Su, Min; Knight, Thomas; Swanson, Michele; Lacy, D Borden; Ohi, Melanie DeLife.2020 Sep 02;32876045
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.Fromm, Simon A; Lawrence, Rosalie E; Hurley, James HNature structural & molecular biology.2020 Nov;32868926
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9?Å.Flores, Jonathan A; Haddad, Bassam G; Dolan, Kimberly A; Myers, Janette B; Yoshioka, Craig C; Copperman, Jeremy; Zuckerman, Daniel M; Reichow, Steve LNature communications.2020 08 28;32859914
Structural basis of transcription-translation coupling.Wang, Chengyuan; Molodtsov, Vadim; Firlar, Emre; Kaelber, Jason T; Blaha, Gregor; Su, Min; Ebright, Richard HScience (New York, N.Y.)2020 09 1132820061
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Edward T; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun M; Darst, Seth A; Campbell, Elizabeth ACell.2020 09 17;32783916
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.Doran, Matthew H; Pavadai, Elumalai; Rynkiewicz, Michael J; Walklate, Jonathan; Bullitt, Esther; Moore, Jeffrey R; Regnier, Michael; Geeves, Michael A; Lehman, WilliamBiophysical journal.2020 Aug 18;32730789
Controlling the SARS-CoV-2 spike glycoprotein conformation.Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie M C; Kopp, Megan; Li, Dapeng; Parks, Rob; Hsu, Allen L; Borgnia, Mario J; Haynes, Barton F; Acharya, PriyamvadaNature structural & molecular biology.2020 10;32699321
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.Liu, Lihong; Wang, Pengfei; Nair, Manoj S; Yu, Jian; Rapp, Micah; Wang, Qian; Luo, Yang; Chan, Jasper F-W; Sahi, Vincent; Figueroa, Amir; Guo, Xinzheng V; Cerutti, Gabriele; Bimela, Jude; Gorman, Jason; Zhou, Tongqing; Chen, Zhiwei; Yuen, Kwok-Yung; KwongNature.2020 08;32698192
Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication.Unchwaniwala, Nuruddin; Zhan, Hong; Pennington, Janice; Horswill, Mark; den Boon, Johan A; Ahlquist, PaulProceedings of the National Academy of Sciences of the United States of America.2020 08 04;32690711
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Ed; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun; Darst, Seth A; Campbell, Elizabeth AbioRxiv : the preprint server for biology.2020 Jul 13;32676607
Chemical and structural investigation of the paroxetine-human serotonin transporter complex.Coleman, Jonathan A; Navratna, Vikas; Antermite, Daniele; Yang, Dongxue; Bull, James A; Gouaux, EriceLife.2020 Jul 03;32618269
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven CbioRxiv : the preprint server for biology2020 Jun 1732587972
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie; Kopp, Megan; Hsu, Allen; Borgnia, Mario; Parks, Rob; Haynes, Barton F; Acharya, PriyamvadabioRxiv : the preprint server for biology.2020 May 18;32511343
Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.Zheng, Xiangdong; Fu, Ziao; Su, Deyuan; Zhang, Yuebin; Li, Minghui; Pan, Yaping; Li, Huan; Li, Shufang; Grassucci, Robert A; Ren, Zhenning; Hu, Zhengshan; Li, Xueming; Zhou, Ming; Li, Guohui; Frank, Joachim; Yang, JianNature structural & molecular biology.2020 07;32483338
Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch.Sobti, Meghna; Walshe, James L; Wu, Di; Ishmukhametov, Robert; Zeng, Yi C; Robinson, Carol V; Berry, Richard M; Stewart, Alastair GNature communications.2020 May 26;32457314
Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery.Eygeris, Yulia; Patel, Siddharth; Jozic, Antony; Sahay, GauravNano letters.2020 06 10;32375002
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.Vien, Thuy N; Wang, Jinliang; Ng, Leo C T; Cao, Erhu; DeCaen, Paul GProceedings of the National Academy of Sciences of the United States of America.2020 May 12;32332171
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.Rahman, Md Mahfuzur; Teng, Jinfeng; Worrell, Brady T; Noviello, Colleen M; Lee, Myeongseon; Karlin, Arthur; Stowell, Michael H B; Hibbs, Ryan ENeuron.2020 06 17;32275860
Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.Yang, Xiaoyong; Wang, Qinzhe; Cao, ErhuNature communications.2020 Feb 21;32081947
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.Gestaut, Daniel; Roh, Soung Hun; Ma, Boxue; Pintilie, Grigore; Joachimiak, Lukasz A; Leitner, Alexander; Walzthoeni, Thomas; Aebersold, Ruedi; Chiu, Wah; Frydman, JudithCell.2019 Apr 18;30955883