Transformative High Resolution Cryo-Electron Microscopy (36)
Publication TitleAuthorsJournalPublication DatePage NoPubMedID
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.Jette, Claudia A; Barnes, Christopher O; Kirk, Sharon M; Melillo, Bruno; Smith 3rd, Amos B; Bjorkman, Pamela JNature communications2021 03 2933782388
Structure of the human Mediator-bound transcription preinitiation complex.Abdella, R; Talyzina, A; Chen, S; Inouye, C J; Tjian, R; He, YScience (New York, N.Y.)2021 04 0233707221
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.Grau, Daniel; Zhang, Yixiao; Lee, Chul-Hwan; Valencia-Sánchez, Marco; Zhang, Jenny; Wang, Miao; Holder, Marlene; Svetlov, Vladimir; Tan, Dongyan; Nudler, Evgeny; Reinberg, Danny; Walz, Thomas; Armache, Karim-JeanNature communications2021 01 2933514705
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven CACS omega2021 Jan 1233458462
The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain.Rangarajan, Erumbi S; Izard, TinaInternational journal of molecular sciences2021 Jan 1133440717
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.Robert Hollingsworth, L; David, Liron; Li, Yang; Griswold, Andrew R; Ruan, Jianbin; Sharif, Humayun; Fontana, Pietro; Orth-He, Elizabeth L; Fu, Tian-Min; Bachovchin, Daniel A; Wu, HaoNature communications2021 01 0833420033
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.Gobeil, Sophie M-C; Janowska, Katarzyna; McDowell, Shana; Mansouri, Katayoun; Parks, Robert; Manne, Kartik; Stalls, Victoria; Kopp, Megan F; Henderson, Rory; Edwards, Robert J; Haynes, Barton F; Acharya, PriyamvadaCell reports2021 01 1233417835
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.Kato, Kazuki; Ahmad, Sadeem; Zhu, Zixiang; Young, Janet M; Mu, Xin; Park, Sehoon; Malik, Harmit S; Hur, SunMolecular cell2021 02 0433373584
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.Zhou, Tongqing; Tsybovsky, Yaroslav; Gorman, Jason; Rapp, Micah; Cerutti, Gabriele; Chuang, Gwo-Yu; Katsamba, Phinikoula S; Sampson, Jared M; Schön, Arne; Bimela, Jude; Boyington, Jeffrey C; Nazzari, Alexandra; Olia, Adam S; Shi, Wei; Sastry, Mallika; Stephens, Tyler; Stuckey, Jonathan; Teng, I-Ting; Wang, Pengfei; Wang, Shuishu; Zhang, Baoshan; Friesner, Richard A; Ho, David D; Mascola, John R; Shapiro, Lawrence; Kwong, Peter DCell host & microbe.2020 12 09;33271067
The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.Santosh, Vishaka; Musayev, Faik N; Jaiswal, Rahul; Zárate-Pérez, Francisco; Vandewinkel, Bram; Dierckx, Caroline; Endicott, Molly; Sharifi, Kamyar; Dryden, Kelly; Henckaerts, Els; Escalante, Carlos RNucleic acids research2020 12 1633270897
Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.Olinares, Paul Dominic B; Kang, Jin Young; Llewellyn, Eliza; Chiu, Courtney; Chen, James; Malone, Brandon; Saecker, Ruth M; Campbell, Elizabeth A; Darst, Seth A; Chait, Brian TStructure (London, England : 1993)2021 02 0433217329
Structural Basis for Virulence Activation of Francisella tularensis.Travis, Brady A; Ramsey, Kathryn M; Prezioso, Samantha M; Tallo, Thomas; Wandzilak, Jamie M; Hsu, Allen; Borgnia, Mario; Bartesaghi, Alberto; Dove, Simon L; Brennan, Richard G; Schumacher, Maria AMolecular cell2021 01 0733217319
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.Liu, Chang; Reese, Rebecca; Vu, Simon; Rougé, Lionel; Shields, Shannon D; Kakiuchi-Kiyota, Satoko; Chen, Huifen; Johnson, Kevin; Shi, Yu Patrick; Chernov-Rogan, Tania; Greiner, Demi Maria Zabala; Kohli, Pawan Bir; Hackos, David; Brillantes, Bobby; Tam, Christine; Li, Tianbo; Wang, Jianyong; Safina, Brian; Magnuson, Steve; Volgraf, Matthew; Payandeh, Jian; Zheng, Jie; Rohou, Alexis; Chen, JunNeuron2021 01 2033152265
Synthetic group A streptogramin antibiotics that overcome Vat resistance.Li, Qi; Pellegrino, Jenna; Lee, D John; Tran, Arthur A; Chaires, Hector A; Wang, Ruoxi; Park, Jesslyn E; Ji, Kaijie; Chow, David; Zhang, Na; Brilot, Axel F; Biel, Justin T; van Zundert, Gydo; Borrelli, Kenneth; Shinabarger, Dean; Wolfe, Cindy; Murray, Beverly; Jacobson, Matthew P; Mühle, Estelle; Chesneau, Olivier; Fraser, James S; Seiple, Ian BNature2020 1032968273
Light-coupled cryo-plunger for time-resolved cryo-EM.Yoder, Nate; Jalali-Yazdi, Farzad; Noreng, Sigrid; Houser, Alexandra; Baconguis, Isabelle; Gouaux, EricJournal of structural biology.2020 Sep 17;32950604
Shared structural mechanisms of general anaesthetics and benzodiazepines.Kim, Jeong Joo; Gharpure, Anant; Teng, Jinfeng; Zhuang, Yuxuan; Howard, Rebecca J; Zhu, Shaotong; Noviello, Colleen M; Walsh Jr, Richard M; Lindahl, Erik; Hibbs, Ryan ENature2020 0932879488
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex.Durie, Clarissa L; Sheedlo, Michael J; Chung, Jeong Min; Byrne, Brenda G; Su, Min; Knight, Thomas; Swanson, Michele; Lacy, D Borden; Ohi, Melanie DeLife.2020 Sep 02;32876045
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.Fromm, Simon A; Lawrence, Rosalie E; Hurley, James HNature structural & molecular biology.2020 Nov;32868926
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9?Å.Flores, Jonathan A; Haddad, Bassam G; Dolan, Kimberly A; Myers, Janette B; Yoshioka, Craig C; Copperman, Jeremy; Zuckerman, Daniel M; Reichow, Steve LNature communications.2020 08 28;32859914
Structural basis of transcription-translation coupling.Wang, Chengyuan; Molodtsov, Vadim; Firlar, Emre; Kaelber, Jason T; Blaha, Gregor; Su, Min; Ebright, Richard HScience (New York, N.Y.)2020 09 1132820061
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Edward T; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun M; Darst, Seth A; Campbell, Elizabeth ACell.2020 09 17;32783916
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.Doran, Matthew H; Pavadai, Elumalai; Rynkiewicz, Michael J; Walklate, Jonathan; Bullitt, Esther; Moore, Jeffrey R; Regnier, Michael; Geeves, Michael A; Lehman, WilliamBiophysical journal.2020 Aug 18;32730789
Controlling the SARS-CoV-2 spike glycoprotein conformation.Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie M C; Kopp, Megan; Li, Dapeng; Parks, Rob; Hsu, Allen L; Borgnia, Mario J; Haynes, Barton F; Acharya, PriyamvadaNature structural & molecular biology.2020 10;32699321
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.Liu, Lihong; Wang, Pengfei; Nair, Manoj S; Yu, Jian; Rapp, Micah; Wang, Qian; Luo, Yang; Chan, Jasper F-W; Sahi, Vincent; Figueroa, Amir; Guo, Xinzheng V; Cerutti, Gabriele; Bimela, Jude; Gorman, Jason; Zhou, Tongqing; Chen, Zhiwei; Yuen, Kwok-Yung; KwongNature.2020 08;32698192
Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication.Unchwaniwala, Nuruddin; Zhan, Hong; Pennington, Janice; Horswill, Mark; den Boon, Johan A; Ahlquist, PaulProceedings of the National Academy of Sciences of the United States of America.2020 08 04;32690711
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Ed; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun; Darst, Seth A; Campbell, Elizabeth AbioRxiv : the preprint server for biology.2020 Jul 13;32676607
Chemical and structural investigation of the paroxetine-human serotonin transporter complex.Coleman, Jonathan A; Navratna, Vikas; Antermite, Daniele; Yang, Dongxue; Bull, James A; Gouaux, EriceLife.2020 Jul 03;32618269
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven CbioRxiv : the preprint server for biology2020 Jun 1732587972
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie; Kopp, Megan; Hsu, Allen; Borgnia, Mario; Parks, Rob; Haynes, Barton F; Acharya, PriyamvadabioRxiv : the preprint server for biology.2020 May 18;32511343
Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.Zheng, Xiangdong; Fu, Ziao; Su, Deyuan; Zhang, Yuebin; Li, Minghui; Pan, Yaping; Li, Huan; Li, Shufang; Grassucci, Robert A; Ren, Zhenning; Hu, Zhengshan; Li, Xueming; Zhou, Ming; Li, Guohui; Frank, Joachim; Yang, JianNature structural & molecular biology.2020 07;32483338
Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch.Sobti, Meghna; Walshe, James L; Wu, Di; Ishmukhametov, Robert; Zeng, Yi C; Robinson, Carol V; Berry, Richard M; Stewart, Alastair GNature communications.2020 May 26;32457314
Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery.Eygeris, Yulia; Patel, Siddharth; Jozic, Antony; Sahay, GauravNano letters.2020 06 10;32375002
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.Vien, Thuy N; Wang, Jinliang; Ng, Leo C T; Cao, Erhu; DeCaen, Paul GProceedings of the National Academy of Sciences of the United States of America.2020 May 12;32332171
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.Rahman, Md Mahfuzur; Teng, Jinfeng; Worrell, Brady T; Noviello, Colleen M; Lee, Myeongseon; Karlin, Arthur; Stowell, Michael H B; Hibbs, Ryan ENeuron.2020 06 17;32275860
Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.Yang, Xiaoyong; Wang, Qinzhe; Cao, ErhuNature communications.2020 Feb 21;32081947
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.Gestaut, Daniel; Roh, Soung Hun; Ma, Boxue; Pintilie, Grigore; Joachimiak, Lukasz A; Leitner, Alexander; Walzthoeni, Thomas; Aebersold, Ruedi; Chiu, Wah; Frydman, JudithCell.2019 Apr 18;30955883