Transformative High Resolution Cryo-Electron Microscopy (57)
Publication TitleAuthorsJournalPublication DatePage NoPubMedID
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.Chen, Peng; Zeng, Ji; Liu, Zheng; Thaker, Hatim; Wang, Siyu; Tian, Songhai; Zhang, Jie; Tao, Liang; Gutierrez, Craig B; Xing, Li; Gerhard, Ralf; Huang, Lan; Dong, Min; Jin, RongshengNature communications2021 06 1834145250
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies.Cerutti, Gabriele; Rapp, Micah; Guo, Yicheng; Bahna, Fabiana; Bimela, Jude; Reddem, Eswar R; Yu, Jian; Wang, Pengfei; Liu, Lihong; Huang, Yaoxing; Ho, David D; Kwong, Peter D; Sheng, Zizhang; Shapiro, LawrenceStructure (London, England : 1993)2021 07 0134111408
Structural insight on assembly-line catalysis in terpene biosynthesis.Faylo, Jacque L; van Eeuwen, Trevor; Kim, Hee Jong; Gorbea Colón, Jose J; Garcia, Benjamin A; Murakami, Kenji; Christianson, David WNature communications2021 06 0934108468
Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair.van Eeuwen, Trevor; Shim, Yoonjung; Kim, Hee Jong; Zhao, Tingting; Basu, Shrabani; Garcia, Benjamin A; Kaplan, Craig D; Min, Jung-Hyun; Murakami, KenjiNature communications2021 06 0734099686
Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy.Driggers, Camden M; Shyng, Show-LingMethods in enzymology202134099169
TRPV3 expression and purification for structure determination by Cryo-EM.Neuberger, Arthur; Nadezhdin, Kirill D; Sobolevsky, Alexander IMethods in enzymology202134059288
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.Williams, Wilton B; Meyerhoff, R Ryan; Edwards, R J; Li, Hui; Manne, Kartik; Nicely, Nathan I; Henderson, Rory; Zhou, Ye; Janowska, Katarzyna; Mansouri, Katayoun; Gobeil, Sophie; Evangelous, Tyler; Hora, Bhavna; Berry, Madison; Abuahmad, A Yousef; Sprenz, Jordan; Deyton, Margaret; Stalls, Victoria; Kopp, Megan; Hsu, Allen L; Borgnia, Mario J; Stewart-Jones, Guillaume B E; Lee, Matthew S; Bronkema, Naomi; Moody, M Anthony; Wiehe, Kevin; Bradley, Todd; Alam, S Munir; Parks, Robert J; Foulger, Andrew; Oguin, Thomas; Sempowski, Gregory D; Bonsignori, Mattia; LaBranche, Celia C; Montefiori, David C; Seaman, Michael; Santra, Sampa; Perfect, John; Francica, Joseph R; Lynn, Geoffrey M; Aussedat, Baptiste; Walkowicz, William E; Laga, Richard; Kelsoe, Garnett; Saunders, Kevin O; Fera, Daniela; Kwong, Peter D; Seder, Robert A; Bartesaghi, Alberto; Shaw, George M; Acharya, Priyamvada; Haynes, Barton FCell2021 05 2734019795
Cryo-EM structure of a thermostable bacterial nanocompartment.Wiryaman, Timothy; Toor, NavtejIUCrJ2021 May 0133953921
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T; Chait, Brian T; Shaw, David E; Landick, Robert; Darst, Seth A; Campbell, Elizabeth AProceedings of the National Academy of Sciences of the United States of America2021 05 1133883267
Structural basis of long-range to short-range synaptic transition in NHEJ.Chen, Siyu; Lee, Linda; Naila, Tasmin; Fishbain, Susan; Wang, Annie; Tomkinson, Alan E; Lees-Miller, Susan P; He, YuanNature2021 May33854234
Extracellular cap domain is an essential component of the TRPV1 gating mechanism.Nadezhdin, Kirill D; Neuberger, Arthur; Nikolaev, Yury A; Murphy, Lyle A; Gracheva, Elena O; Bagriantsev, Sviatoslav N; Sobolevsky, Alexander INature communications2021 04 1233846324
Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.Shen, Betty W; Quispe, Joel D; Luyten, Yvette; McGough, Benjamin E; Morgan, Richard D; Stoddard, Barry LStructure (London, England : 1993)2021 Jun 0333826880
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.Rapp, Micah; Guo, Yicheng; Reddem, Eswar R; Yu, Jian; Liu, Lihong; Wang, Pengfei; Cerutti, Gabriele; Katsamba, Phinikoula; Bimela, Jude S; Bahna, Fabiana A; Mannepalli, Seetha M; Zhang, Baoshan; Kwong, Peter D; Huang, Yaoxing; Ho, David D; Shapiro, Lawrence; Sheng, ZizhangCell reports2021 04 0633794145
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.Cerutti, Gabriele; Guo, Yicheng; Zhou, Tongqing; Gorman, Jason; Lee, Myungjin; Rapp, Micah; Reddem, Eswar R; Yu, Jian; Bahna, Fabiana; Bimela, Jude; Huang, Yaoxing; Katsamba, Phinikoula S; Liu, Lihong; Nair, Manoj S; Rawi, Reda; Olia, Adam S; Wang, Pengfei; Zhang, Baoshan; Chuang, Gwo-Yu; Ho, David D; Sheng, Zizhang; Kwong, Peter D; Shapiro, LawrenceCell host & microbe2021 05 1233789084
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.Jette, Claudia A; Barnes, Christopher O; Kirk, Sharon M; Melillo, Bruno; Smith 3rd, Amos B; Bjorkman, Pamela JNature communications2021 03 2933782388
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.Malone, Brandon; Chen, James; Wang, Qi; Llewellyn, Eliza; Choi, Young Joo; Olinares, Paul Dominic B; Cao, Xinyun; Hernandez, Carolina; Eng, Edward T; Chait, Brian T; Shaw, David E; Landick, Robert; Darst, Seth A; Campbell, Elizabeth AbioRxiv : the preprint server for biology2021 Mar 1433758867
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes.Sun, Dapeng; Sang, Zhe; Kim, Yong Joon; Xiang, Yufei; Cohen, Tomer; Belford, Anna K; Huet, Alexis; Conway, James F; Sun, Ji; Taylor, Derek J; Schneidman-Duhovny, Dina; Zhang, Cheng; Huang, Wei; Shi, YibioRxiv : the preprint server for biology2021 Mar 1033758850
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.Noviello, Colleen M; Gharpure, Anant; Mukhtasimova, Nuriya; Cabuco, Rico; Baxter, Leah; Borek, Dominika; Sine, Steven M; Hibbs, Ryan ECell2021 Apr 1533735609
Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.Moghadamchargari, Zahra; Shirzadeh, Mehdi; Liu, Chang; Schrecke, Samantha; Packianathan, Charles; Russell, David H; Zhao, Minglei; Laganowsky, ArthurProceedings of the National Academy of Sciences of the United States of America2021 Mar 2333723061
Structure of the human Mediator-bound transcription preinitiation complex.Abdella, R; Talyzina, A; Chen, S; Inouye, C J; Tjian, R; He, YScience (New York, N.Y.)2021 04 0233707221
CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy.Yang, Jie E; Larson, Matthew R; Sibert, Bryan S; Shrum, Samantha; Wright, Elizabeth RJournal of structural biology2021 Feb 1833610654
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.Grau, Daniel; Zhang, Yixiao; Lee, Chul-Hwan; Valencia-Sánchez, Marco; Zhang, Jenny; Wang, Miao; Holder, Marlene; Svetlov, Vladimir; Tan, Dongyan; Nudler, Evgeny; Reinberg, Danny; Walz, Thomas; Armache, Karim-JeanNature communications2021 01 2933514705
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven CACS omega2021 Jan 1233458462
The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain.Rangarajan, Erumbi S; Izard, TinaInternational journal of molecular sciences2021 Jan 1133440717
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.Robert Hollingsworth, L; David, Liron; Li, Yang; Griswold, Andrew R; Ruan, Jianbin; Sharif, Humayun; Fontana, Pietro; Orth-He, Elizabeth L; Fu, Tian-Min; Bachovchin, Daniel A; Wu, HaoNature communications2021 01 0833420033
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.Gobeil, Sophie M-C; Janowska, Katarzyna; McDowell, Shana; Mansouri, Katayoun; Parks, Robert; Manne, Kartik; Stalls, Victoria; Kopp, Megan F; Henderson, Rory; Edwards, Robert J; Haynes, Barton F; Acharya, PriyamvadaCell reports2021 01 1233417835
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.Kato, Kazuki; Ahmad, Sadeem; Zhu, Zixiang; Young, Janet M; Mu, Xin; Park, Sehoon; Malik, Harmit S; Hur, SunMolecular cell2021 02 0433373584
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.Zhou, Tongqing; Tsybovsky, Yaroslav; Gorman, Jason; Rapp, Micah; Cerutti, Gabriele; Chuang, Gwo-Yu; Katsamba, Phinikoula S; Sampson, Jared M; Schön, Arne; Bimela, Jude; Boyington, Jeffrey C; Nazzari, Alexandra; Olia, Adam S; Shi, Wei; Sastry, Mallika; Stephens, Tyler; Stuckey, Jonathan; Teng, I-Ting; Wang, Pengfei; Wang, Shuishu; Zhang, Baoshan; Friesner, Richard A; Ho, David D; Mascola, John R; Shapiro, Lawrence; Kwong, Peter DCell host & microbe.2020 12 09;33271067
The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.Santosh, Vishaka; Musayev, Faik N; Jaiswal, Rahul; Zárate-Pérez, Francisco; Vandewinkel, Bram; Dierckx, Caroline; Endicott, Molly; Sharifi, Kamyar; Dryden, Kelly; Henckaerts, Els; Escalante, Carlos RNucleic acids research2020 12 1633270897
The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors.Silveria, Mark A; Large, Edward E; Zane, Grant M; White, Tommi A; Chapman, Michael SViruses2020 11 1833218165
Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.Olinares, Paul Dominic B; Kang, Jin Young; Llewellyn, Eliza; Chiu, Courtney; Chen, James; Malone, Brandon; Saecker, Ruth M; Campbell, Elizabeth A; Darst, Seth A; Chait, Brian TStructure (London, England : 1993)2021 02 0433217329
Structural Basis for Virulence Activation of Francisella tularensis.Travis, Brady A; Ramsey, Kathryn M; Prezioso, Samantha M; Tallo, Thomas; Wandzilak, Jamie M; Hsu, Allen; Borgnia, Mario; Bartesaghi, Alberto; Dove, Simon L; Brennan, Richard G; Schumacher, Maria AMolecular cell2021 01 0733217319
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel.Liu, Chang; Reese, Rebecca; Vu, Simon; Rougé, Lionel; Shields, Shannon D; Kakiuchi-Kiyota, Satoko; Chen, Huifen; Johnson, Kevin; Shi, Yu Patrick; Chernov-Rogan, Tania; Greiner, Demi Maria Zabala; Kohli, Pawan Bir; Hackos, David; Brillantes, Bobby; Tam, Christine; Li, Tianbo; Wang, Jianyong; Safina, Brian; Magnuson, Steve; Volgraf, Matthew; Payandeh, Jian; Zheng, Jie; Rohou, Alexis; Chen, JunNeuron2021 01 2033152265
Adeno-Associated Virus (AAV-DJ)-Cryo-EM Structure at 1.56 Å Resolution.Xie, Qing; Yoshioka, Craig K; Chapman, Michael SViruses2020 10 2033092282
Synthetic group A streptogramin antibiotics that overcome Vat resistance.Li, Qi; Pellegrino, Jenna; Lee, D John; Tran, Arthur A; Chaires, Hector A; Wang, Ruoxi; Park, Jesslyn E; Ji, Kaijie; Chow, David; Zhang, Na; Brilot, Axel F; Biel, Justin T; van Zundert, Gydo; Borrelli, Kenneth; Shinabarger, Dean; Wolfe, Cindy; Murray, Beverly; Jacobson, Matthew P; Mühle, Estelle; Chesneau, Olivier; Fraser, James S; Seiple, Ian BNature2020 1032968273
Light-coupled cryo-plunger for time-resolved cryo-EM.Yoder, Nate; Jalali-Yazdi, Farzad; Noreng, Sigrid; Houser, Alexandra; Baconguis, Isabelle; Gouaux, EricJournal of structural biology.2020 Sep 17;32950604
Shared structural mechanisms of general anaesthetics and benzodiazepines.Kim, Jeong Joo; Gharpure, Anant; Teng, Jinfeng; Zhuang, Yuxuan; Howard, Rebecca J; Zhu, Shaotong; Noviello, Colleen M; Walsh Jr, Richard M; Lindahl, Erik; Hibbs, Ryan ENature2020 0932879488
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex.Durie, Clarissa L; Sheedlo, Michael J; Chung, Jeong Min; Byrne, Brenda G; Su, Min; Knight, Thomas; Swanson, Michele; Lacy, D Borden; Ohi, Melanie DeLife.2020 Sep 02;32876045
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.Fromm, Simon A; Lawrence, Rosalie E; Hurley, James HNature structural & molecular biology.2020 Nov;32868926
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9?Å.Flores, Jonathan A; Haddad, Bassam G; Dolan, Kimberly A; Myers, Janette B; Yoshioka, Craig C; Copperman, Jeremy; Zuckerman, Daniel M; Reichow, Steve LNature communications.2020 08 28;32859914
Structural basis of transcription-translation coupling.Wang, Chengyuan; Molodtsov, Vadim; Firlar, Emre; Kaelber, Jason T; Blaha, Gregor; Su, Min; Ebright, Richard HScience (New York, N.Y.)2020 09 1132820061
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Edward T; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun M; Darst, Seth A; Campbell, Elizabeth ACell.2020 09 17;32783916
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.Doran, Matthew H; Pavadai, Elumalai; Rynkiewicz, Michael J; Walklate, Jonathan; Bullitt, Esther; Moore, Jeffrey R; Regnier, Michael; Geeves, Michael A; Lehman, WilliamBiophysical journal.2020 Aug 18;32730789
Controlling the SARS-CoV-2 spike glycoprotein conformation.Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie M C; Kopp, Megan; Li, Dapeng; Parks, Rob; Hsu, Allen L; Borgnia, Mario J; Haynes, Barton F; Acharya, PriyamvadaNature structural & molecular biology.2020 10;32699321
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike.Liu, Lihong; Wang, Pengfei; Nair, Manoj S; Yu, Jian; Rapp, Micah; Wang, Qian; Luo, Yang; Chan, Jasper F-W; Sahi, Vincent; Figueroa, Amir; Guo, Xinzheng V; Cerutti, Gabriele; Bimela, Jude; Gorman, Jason; Zhou, Tongqing; Chen, Zhiwei; Yuen, Kwok-Yung; KwongNature.2020 08;32698192
Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication.Unchwaniwala, Nuruddin; Zhan, Hong; Pennington, Janice; Horswill, Mark; den Boon, Johan A; Ahlquist, PaulProceedings of the National Academy of Sciences of the United States of America.2020 08 04;32690711
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.Chen, James; Malone, Brandon; Llewellyn, Eliza; Grasso, Michael; Shelton, Patrick M M; Olinares, Paul Dominic B; Maruthi, Kashyap; Eng, Ed; Vatandaslar, Hasan; Chait, Brian T; Kapoor, Tarun; Darst, Seth A; Campbell, Elizabeth AbioRxiv : the preprint server for biology.2020 Jul 13;32676607
Chemical and structural investigation of the paroxetine-human serotonin transporter complex.Coleman, Jonathan A; Navratna, Vikas; Antermite, Daniele; Yang, Dongxue; Bull, James A; Gouaux, EriceLife.2020 Jul 03;32618269
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.Herrera, Natalia G; Morano, Nicholas C; Celikgil, Alev; Georgiev, George I; Malonis, Ryan J; Lee, James H; Tong, Karen; Vergnolle, Olivia; Massimi, Aldo B; Yen, Laura Y; Noble, Alex J; Kopylov, Mykhailo; Bonanno, Jeffrey B; Garrett-Thomson, Sarah C; Hayes, David B; Bortz 3rd, Robert H; Wirchnianski, Ariel S; Florez, Catalina; Laudermilch, Ethan; Haslwanter, Denise; Fels, J Maximilian; Dieterle, M Eugenia; Jangra, Rohit K; Barnhill, Jason; Mengotto, Amanda; Kimmel, Duncan; Daily, Johanna P; Pirofski, Liise-Anne; Chandran, Kartik; Brenowitz, Michael; Garforth, Scott J; Eng, Edward T; Lai, Jonathan R; Almo, Steven CbioRxiv : the preprint server for biology2020 Jun 1732587972
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.Henderson, Rory; Edwards, Robert J; Mansouri, Katayoun; Janowska, Katarzyna; Stalls, Victoria; Gobeil, Sophie; Kopp, Megan; Hsu, Allen; Borgnia, Mario; Parks, Rob; Haynes, Barton F; Acharya, PriyamvadabioRxiv : the preprint server for biology.2020 May 18;32511343
Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.Zheng, Xiangdong; Fu, Ziao; Su, Deyuan; Zhang, Yuebin; Li, Minghui; Pan, Yaping; Li, Huan; Li, Shufang; Grassucci, Robert A; Ren, Zhenning; Hu, Zhengshan; Li, Xueming; Zhou, Ming; Li, Guohui; Frank, Joachim; Yang, JianNature structural & molecular biology.2020 07;32483338
Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch.Sobti, Meghna; Walshe, James L; Wu, Di; Ishmukhametov, Robert; Zeng, Yi C; Robinson, Carol V; Berry, Richard M; Stewart, Alastair GNature communications.2020 May 26;32457314
Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery.Eygeris, Yulia; Patel, Siddharth; Jozic, Antony; Sahay, GauravNano letters.2020 06 10;32375002
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.Vien, Thuy N; Wang, Jinliang; Ng, Leo C T; Cao, Erhu; DeCaen, Paul GProceedings of the National Academy of Sciences of the United States of America.2020 May 12;32332171
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.Rahman, Md Mahfuzur; Teng, Jinfeng; Worrell, Brady T; Noviello, Colleen M; Lee, Myeongseon; Karlin, Arthur; Stowell, Michael H B; Hibbs, Ryan ENeuron.2020 06 17;32275860
Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.Yang, Xiaoyong; Wang, Qinzhe; Cao, ErhuNature communications.2020 Feb 21;32081947
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.Gestaut, Daniel; Roh, Soung Hun; Ma, Boxue; Pintilie, Grigore; Joachimiak, Lukasz A; Leitner, Alexander; Walzthoeni, Thomas; Aebersold, Ruedi; Chiu, Wah; Frydman, JudithCell.2019 Apr 18;30955883