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Program Snapshot

The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program aims to develop a “library” of molecular signatures that describes how different types of cells respond to a variety of perturbing agents. The pilot phase of the program was completed in fiscal year 2013 and focused on the following activities:

  • Large-scale production of perturbation-induced molecular and cellular signatures
  • Creation of a database, common data standards and public user interface for accessing the data
  • Computational tool development and integrative data analyses
  • Development of new cost-effective, molecular and cellular phenotypic assays
  • Integration of existing datasets into LINCS

Furthermore, as of October 2013 (fiscal year 2014), continuation of the program was implemented to capitalize on the pilot phase. This new focused stage of the program supports LINCS Data and Signature Analysis Centers and coordinates with the NIH Big Data to Knowledge (BD2K) program.

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Program Highlights

LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce 

Cancer, generally speaking, occurs due to unregulated cell reproduction. As cells grow and multiply unchecked they need to produce more proteins, ultimately leading to the formation of tumors.

Program Highlights

LINCS Researchers Find New Insights into Measures of Drug ActivityLINCS Researchers Find New Insights into Measures of Drug Activity

More effective therapeutics are needed for numerous conditions affecting people, yet drug development remains inefficient.

Notice of Availability of Administrative Supplements to Extend the Scope and Reach of LINCS Datasets. This Notice announces an opportunity to request administrative supplements to existing NIH research grants, to support generation of new data that will also advance the goals of the LINCS program. Applications are Due May 15, 2015. Learn how to apply.

Request for Applications: BD2K-LINCS Data Coordination and Integration Center External Data Science Research Projects. The BD2K-LINCS Data Coordination and Integration Center (DCIC) is soliciting applications from the scientific community for data science research collaborations with the DCIC that focus on mining and integrating data generated by the LINCS program for new scientific discovery. The overarching goal of this solicitation is to maximize the value of LINCS data and transform it into new knowledge. The DCIC, via a subcontract, will support collaboration projects with a budget limit of $130K in total costs per year for up to two years. Applications are Due May 1, 2015. Learn how to apply. Exit Disclaimer

Grants for Second Phase of LINCS Program Awarded. After a successful 3-year pilot project, the NIH announces $64 million in awards to establish 6 LINCS Data and Signature Generating Centers. Read the press release.

NIH LINCS Program​​
ACCESS THE LINCS PORTAL The LINCS portal is a source of information for the research community and general public about the LINCS project.  The portal contains details about the assays, cell types, and perturbagens currently part of the library, as well as links to participating sites, the data releases from the sites, and software that can be used for analyzing the data. Click on the image below to get started. Exit Disclaimer


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