The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program aims to develop a “library” of molecular signatures that describes how different types of cells respond to a variety of perturbing agents. The pilot phase of the program was completed in fiscal year 2013 and focused on the following activities:
- Large-scale production of perturbation-induced molecular and cellular signatures
- Creation of a database, common data standards and public user interface for accessing the data
- Computational tool development and integrative data analyses
- Development of new cost-effective, molecular and cellular phenotypic assays
- Integration of existing datasets into LINCS
Furthermore, as of October 2013 (fiscal year 2014), continuation of the program was implemented to capitalize on the pilot phase. This new focused stage of the program supports LINCS Data and Signature Analysis Centers and coordinates with the NIH Big Data to Knowledge (BD2K) program.
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