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Program Snapshot

The Common Fund’s Library of Integrated Network-based Cellular Signatures (LINCS) program aims to develop a “library” of molecular signatures that describes how different types of cells respond to a variety of perturbing agents. The pilot phase of the program was completed in fiscal year 2013 and focused on the following activities:

  • Large-scale production of perturbation-induced molecular and cellular signatures
  • Creation of a database, common data standards and public user interface for accessing the data
  • Computational tool development and integrative data analyses
  • Development of new cost-effective, molecular and cellular phenotypic assays
  • Integration of existing datasets into LINCS

Furthermore, as of October 2013 (fiscal year 2014), continuation of the program was implemented to capitalize on the pilot phase. This new focused stage of the program supports LINCS Data and Signature Analysis Centers and coordinates with the NIH Big Data to Knowledge (BD2K) program.

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Program Highlights

LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce LINCS Data Harnessed to Help Reveal How Cancer Cells Continuously Reproduce 

Cancer, generally speaking, occurs due to unregulated cell reproduction. As cells grow and multiply unchecked they need to produce more proteins, ultimately leading to the formation of tumors.

Program Highlights

LINCS Researchers Find New Insights into Measures of Drug ActivityLINCS Researchers Find New Insights into Measures of Drug Activity

More effective therapeutics are needed for numerous conditions affecting people, yet drug development remains inefficient.

LINCS and Big Data in Genetics. Learn how high-throughput data from the LINCS program could contribute to our understanding of cancer and other diseases in this editorial from Nature. Exit Disclaimer

Studying Sex DifferencesLINCS Scientists Investigate Sex Differences. Sex and gender play a role in how health and disease differ across individuals, and considering these factors during research informs the development of preventive and therapeutic interventions for both sexes. Learn how supplements to LINCS grants are enabling researchers to investigate sex as a biological variable.

LINCS Data Science Research Webinars. Want to learn more about the LINCS data and how you can use them in your research? Join the LINCS Data Science Research Webinars held on select Tuesdays at 3:00 PM Eastern Time. See upcoming webinars and view archived webinars

NIH LINCS Program​​
ACCESS THE LINCS PORTAL The LINCS portal is a source of information for the research community and general public about the LINCS project.  The portal contains details about the assays, cell types, and perturbagens currently part of the library, as well as links to participating sites, the data releases from the sites, and software that can be used for analyzing the data. Click on the image below to get started. Exit Disclaimer


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