The Common Fund's Genotype-Tissue Expression (GTEx) program aims to study human gene expression and regulation in multiple tissues, providing valuable insights into the mechanisms of gene regulation and, in the future, its disease-related perturbations. Genetic variation between individuals will be examined for correlation with differences in gene expression level to identify regions of the genome that influence whether and how much a gene is expressed. The GTEx project includes the following initiatives:
- Novel Statistical Methods for Human Gene Expression Quantitative Trait Loci (eQTL) Analysis
- Laboratory, Data Analysis, and Coordinating Center (LDACC)
- caHUB Acquisition of Normal Tissues in Support of the GTEx Project
Scientists Use GTEx Data to Help Predict Genes Associated with Disease
Researchers at the University of Chicago and their collaborators have developed PrediXcan, a computational method that links genetic variation and gene activity to disease traits. The method uses gene activity datasets like the Genotype-Tissue Expression (GTEx) data to train the computer to associate certain genetic profiles with certain diseases. The technique has important implications for linking genetics to disease susceptibility.
The GTEx (Genotype-Tissue Expression) Project. Correlations between genotype and tissue-specific gene expression levels will help identify regions of the genome that influence whether and how much a gene is expressed. GTEx will help researchers to understand inherited susceptibility to disease and will be a resource database and tissue bank for many studies in the future.